NAT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)8.50518405
2urate metabolic process (GO:0046415)8.42861216
3glyoxylate metabolic process (GO:0046487)7.24640592
4aminoglycoside antibiotic metabolic process (GO:0030647)7.19799462
5drug transport (GO:0015893)7.18922407
6lysine metabolic process (GO:0006553)7.13846566
7lysine catabolic process (GO:0006554)7.13846566
8cysteine metabolic process (GO:0006534)6.92986742
9epoxygenase P450 pathway (GO:0019373)6.82050840
10exogenous drug catabolic process (GO:0042738)6.74338142
11drug catabolic process (GO:0042737)6.71482991
12L-phenylalanine catabolic process (GO:0006559)6.45821163
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.45821163
14negative regulation of cholesterol transport (GO:0032375)6.45217775
15negative regulation of sterol transport (GO:0032372)6.45217775
16L-phenylalanine metabolic process (GO:0006558)6.39320679
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.39320679
18organic cation transport (GO:0015695)6.26608059
19aromatic amino acid family catabolic process (GO:0009074)5.97862125
20phosphate ion transport (GO:0006817)5.95794196
21regulation of fibrinolysis (GO:0051917)5.91999126
22negative regulation of fibrinolysis (GO:0051918)5.85759550
23regulation of protein activation cascade (GO:2000257)5.81275913
24complement activation, alternative pathway (GO:0006957)5.75474568
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.66917617
26omega-hydroxylase P450 pathway (GO:0097267)5.64929685
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.63457799
28tryptophan catabolic process (GO:0006569)5.60181334
29indole-containing compound catabolic process (GO:0042436)5.60181334
30indolalkylamine catabolic process (GO:0046218)5.60181334
31regulation of complement activation (GO:0030449)5.55857760
32serine family amino acid catabolic process (GO:0009071)5.50245661
33high-density lipoprotein particle remodeling (GO:0034375)5.45628520
34homocysteine metabolic process (GO:0050667)5.43643022
35regulation of cholesterol esterification (GO:0010872)5.41120192
36cellular modified amino acid catabolic process (GO:0042219)5.33494160
37blood coagulation, intrinsic pathway (GO:0007597)5.29798170
38tryptophan metabolic process (GO:0006568)5.28376518
39short-chain fatty acid metabolic process (GO:0046459)5.24327552
40quaternary ammonium group transport (GO:0015697)5.22034031
41aspartate family amino acid catabolic process (GO:0009068)5.14881334
42serine family amino acid metabolic process (GO:0009069)5.09216692
43phospholipid efflux (GO:0033700)5.09154570
44phosphate ion transmembrane transport (GO:0035435)5.07020896
45peptidyl-glutamic acid carboxylation (GO:0017187)5.04807544
46protein carboxylation (GO:0018214)5.04807544
47response to mercury ion (GO:0046689)5.04300351
48metanephric nephron tubule development (GO:0072234)4.98384007
49metanephric tubule development (GO:0072170)4.98384007
50reverse cholesterol transport (GO:0043691)4.94400155
51sulfur amino acid catabolic process (GO:0000098)4.89175497
52fibrinolysis (GO:0042730)4.81897074
53tricarboxylic acid metabolic process (GO:0072350)4.81739434
54amino-acid betaine metabolic process (GO:0006577)4.79065730
55nonribosomal peptide biosynthetic process (GO:0019184)4.78258079
56protein-lipid complex remodeling (GO:0034368)4.77988960
57macromolecular complex remodeling (GO:0034367)4.77988960
58plasma lipoprotein particle remodeling (GO:0034369)4.77988960
59branched-chain amino acid metabolic process (GO:0009081)4.68813526
60serine family amino acid biosynthetic process (GO:0009070)4.67668035
61metanephric nephron epithelium development (GO:0072243)4.64215197
62kynurenine metabolic process (GO:0070189)4.54396971
63regulation of triglyceride catabolic process (GO:0010896)4.49726207
64alpha-amino acid catabolic process (GO:1901606)4.46683930
65cellular amino acid catabolic process (GO:0009063)4.44367160
66aromatic amino acid family metabolic process (GO:0009072)4.40670945
67valine metabolic process (GO:0006573)4.40344501
68bile acid biosynthetic process (GO:0006699)4.39727374
69cholesterol efflux (GO:0033344)4.37616281
70glutathione biosynthetic process (GO:0006750)4.34814212
71cellular ketone body metabolic process (GO:0046950)4.33543905
72proline metabolic process (GO:0006560)4.28673822
73fatty acid beta-oxidation (GO:0006635)4.28575602
74glutamate metabolic process (GO:0006536)4.26778642
75fructose metabolic process (GO:0006000)4.25959344
76metanephric epithelium development (GO:0072207)4.23552944
77acylglycerol homeostasis (GO:0055090)4.22827971
78triglyceride homeostasis (GO:0070328)4.22827971
79flavonoid metabolic process (GO:0009812)4.22117800
80cellular glucuronidation (GO:0052695)4.20962414
81negative regulation of hemostasis (GO:1900047)4.19826220
82negative regulation of blood coagulation (GO:0030195)4.19826220
83glucuronate metabolic process (GO:0019585)4.17982319
84uronic acid metabolic process (GO:0006063)4.17982319
85very-low-density lipoprotein particle assembly (GO:0034379)4.16910446
86plasma lipoprotein particle assembly (GO:0034377)4.15231389
87branched-chain amino acid catabolic process (GO:0009083)4.14097519
882-oxoglutarate metabolic process (GO:0006103)4.12286822
89polyol transport (GO:0015791)4.11692212
90ethanol metabolic process (GO:0006067)4.09943695
91acetyl-CoA metabolic process (GO:0006084)4.09576417
92fatty acid oxidation (GO:0019395)4.07827404
93regulation of plasminogen activation (GO:0010755)4.07243408
94S-adenosylmethionine metabolic process (GO:0046500)4.06556964
95lipid oxidation (GO:0034440)4.02828900
96carnitine metabolic process (GO:0009437)3.97953356
97carboxylic acid catabolic process (GO:0046395)3.95746738
98organic acid catabolic process (GO:0016054)3.95746738
99indolalkylamine metabolic process (GO:0006586)3.92956907
100protein activation cascade (GO:0072376)3.91468204
101benzene-containing compound metabolic process (GO:0042537)3.88765463
102negative regulation of coagulation (GO:0050819)3.85727378
103carnitine transport (GO:0015879)3.84648265
104amino-acid betaine transport (GO:0015838)3.84648265
105fatty acid catabolic process (GO:0009062)3.82848397
106plasma lipoprotein particle clearance (GO:0034381)3.80930370
107vitamin D metabolic process (GO:0042359)3.80794584
108low-density lipoprotein particle remodeling (GO:0034374)3.80677954
109excretion (GO:0007588)3.79579696
110modified amino acid transport (GO:0072337)3.79480396
111drug metabolic process (GO:0017144)3.78795835
112negative regulation of lipase activity (GO:0060192)3.78523048
113cellular biogenic amine catabolic process (GO:0042402)3.78393513
114amine catabolic process (GO:0009310)3.78393513
115ketone body metabolic process (GO:1902224)3.74619675
116monocarboxylic acid catabolic process (GO:0072329)3.73720636
117bile acid and bile salt transport (GO:0015721)3.72263193
118phosphate ion homeostasis (GO:0055062)3.71962004
119trivalent inorganic anion homeostasis (GO:0072506)3.71962004
120positive regulation of lipoprotein lipase activity (GO:0051006)3.71822779
121positive regulation of triglyceride lipase activity (GO:0061365)3.71822779
122plasma lipoprotein particle organization (GO:0071827)3.71716098
123renal absorption (GO:0070293)3.69235629
124negative regulation of wound healing (GO:0061045)3.68277194
125protein-lipid complex assembly (GO:0065005)3.67793896
126phospholipid homeostasis (GO:0055091)3.66501746
127alpha-linolenic acid metabolic process (GO:0036109)3.66483432
128dicarboxylic acid biosynthetic process (GO:0043650)3.64603640
129aldehyde catabolic process (GO:0046185)3.61709943
130indole-containing compound metabolic process (GO:0042430)3.58727637
131toxin transport (GO:1901998)3.58264175
132response to phenylpropanoid (GO:0080184)3.58191508
133regulation of cholesterol homeostasis (GO:2000188)3.55990481
134glycine metabolic process (GO:0006544)3.54741060
135coenzyme catabolic process (GO:0009109)3.54423431
136phenylpropanoid metabolic process (GO:0009698)3.53325537
137ethanol oxidation (GO:0006069)3.52863421
138oxidative demethylation (GO:0070989)3.52414730
139fat-soluble vitamin biosynthetic process (GO:0042362)3.52297455
140urea metabolic process (GO:0019627)3.52038773
141urea cycle (GO:0000050)3.52038773
142protein-lipid complex subunit organization (GO:0071825)3.48478392
143nephron tubule development (GO:0072080)3.47637397
144peptide biosynthetic process (GO:0043043)3.47268854
145bile acid metabolic process (GO:0008206)3.46414688
146glutathione derivative biosynthetic process (GO:1901687)3.45990457
147glutathione derivative metabolic process (GO:1901685)3.45990457
148dicarboxylic acid metabolic process (GO:0043648)3.44257774
149regulation of humoral immune response (GO:0002920)3.42028057
150complement activation, classical pathway (GO:0006958)3.41213665
151small molecule catabolic process (GO:0044282)3.41189415
152tyrosine metabolic process (GO:0006570)3.40994425
153lipoprotein metabolic process (GO:0042157)3.40421974
154negative regulation of protein activation cascade (GO:2000258)3.40233748
155negative regulation of lipid transport (GO:0032369)3.37933444
156nitrogen cycle metabolic process (GO:0071941)3.35327802
157complement activation (GO:0006956)3.35048939
158imidazole-containing compound metabolic process (GO:0052803)3.34694318
159sulfur amino acid metabolic process (GO:0000096)3.32098131
160sodium-independent organic anion transport (GO:0043252)3.32038160
161actin filament depolymerization (GO:0030042)3.31927437
162positive regulation of blood coagulation (GO:0030194)3.30759855
163positive regulation of hemostasis (GO:1900048)3.30759855
164peptide catabolic process (GO:0043171)3.29604381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.73109408
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.16776151
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.18461196
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.40153246
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78423879
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.78234656
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.78238960
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14750687
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.92668622
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.85745556
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.63069039
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57621295
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11913198
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.11444208
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.93162909
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87019847
17CLOCK_20551151_ChIP-Seq_293T_Human1.86649723
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.65466620
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.65216979
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.62722362
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56891687
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54252568
23* CDX2_20551321_ChIP-Seq_CACO-2_Human1.54125939
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53761483
25HTT_18923047_ChIP-ChIP_STHdh_Human1.52633139
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52452533
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41539206
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.40239679
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38743860
30GATA4_25053715_ChIP-Seq_YYC3_Human1.35830154
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28677582
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22712527
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22183449
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.21427257
35LXR_22292898_ChIP-Seq_THP-1_Human1.19131216
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.14866478
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13220046
38AR_21909140_ChIP-Seq_LNCAP_Human1.13111439
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.11409832
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00108497
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99130151
42EGR1_19032775_ChIP-ChIP_M12_Human0.97824147
43DROSHA_22980978_ChIP-Seq_HELA_Human0.95494977
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95476958
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95246924
46HNFA_21074721_ChIP-Seq_CACO-2_Human0.93914022
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93584358
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93319131
49GATA2_21666600_ChIP-Seq_HMVEC_Human0.92939015
50RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92752027
51RACK7_27058665_Chip-Seq_MCF-7_Human0.91581325
52BCAT_22108803_ChIP-Seq_LS180_Human0.90909841
53FOXA1_25552417_ChIP-Seq_VCAP_Human0.90156015
54GATA6_25053715_ChIP-Seq_YYC3_Human0.89972598
55RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89130260
56ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88848570
57FOXO3_23340844_ChIP-Seq_DLD1_Human0.88574696
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88103957
59NFYA_21822215_ChIP-Seq_K562_Human0.86048430
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83801294
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83278509
62GATA1_19941826_ChIP-Seq_K562_Human0.82761371
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82537959
64PHF8_20622853_ChIP-Seq_HELA_Human0.82264563
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82133641
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.81090301
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78969935
68MYC_19915707_ChIP-ChIP_AK7_Human0.77819005
69TAF2_19829295_ChIP-Seq_ESCs_Human0.77289322
70ERG_21242973_ChIP-ChIP_JURKAT_Human0.77231539
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77124634
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75272877
73SOX2_20726797_ChIP-Seq_SW620_Human0.74942615
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.73871473
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73799730
76PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73446913
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.72770733
78CEBPB_22108803_ChIP-Seq_LS180_Human0.72482923
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72410765
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71910362
81AR_20517297_ChIP-Seq_VCAP_Human0.71096938
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70778466
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69902645
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69749718
85OCT4_18555785_Chip-Seq_ESCs_Mouse0.69672255
86IRF8_22096565_ChIP-ChIP_GC-B_Human0.68930626
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68424911
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.68157004
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67874336
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67663481
91TBX20_22328084_ChIP-Seq_HEART_Mouse0.66596887
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.66596887
93RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66328234
94TP53_18474530_ChIP-ChIP_U2OS_Human0.65125030
95ESRRB_18555785_Chip-Seq_ESCs_Mouse0.64970157
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64969828
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64937240
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64670349
99NFYB_21822215_ChIP-Seq_K562_Human0.63967054
100* ETV1_20927104_ChIP-Seq_GIST48_Human0.63878930
101P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63423133
102PU1_27457419_Chip-Seq_LIVER_Mouse0.63163480
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.62887107
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62685430
105CDX2_22108803_ChIP-Seq_LS180_Human0.62525767
106CBP_21632823_ChIP-Seq_H3396_Human0.62332579
107VDR_24787735_ChIP-Seq_THP-1_Human0.61485567
108ZNF217_24962896_ChIP-Seq_MCF-7_Human0.61173417
109SMAD1_18555785_Chip-Seq_ESCs_Mouse0.61070402
110CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60718053
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60569861
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60569861
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.60534580
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60498271
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60483334
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.60429778
117GATA6_21074721_ChIP-Seq_CACO-2_Human0.60252736
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.59267957
119STAT3_18555785_Chip-Seq_ESCs_Mouse0.59262359
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59109449
121ZFX_18555785_Chip-Seq_ESCs_Mouse0.58979481
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.58304250
123GATA2_19941826_ChIP-Seq_K562_Human0.57507479
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.57254588
125RAC3_21632823_ChIP-Seq_H3396_Human0.57246847
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.57063933
127GATA1_22025678_ChIP-Seq_K562_Human0.56474923
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56064011
129* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55549794
130RXR_22108803_ChIP-Seq_LS180_Human0.55435997
131CTCF_27219007_Chip-Seq_Bcells_Human0.55015243
132* ESET_19884257_ChIP-Seq_ESCs_Mouse0.54522180
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.54138491
134TP63_23658742_ChIP-Seq_EP156T_Human0.53881104
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.53789265
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.53316911
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.53214847
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52331014
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.52154316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.67499516
2MP0002139_abnormal_hepatobiliary_system6.99558849
3MP0005332_abnormal_amino_acid4.56330370
4MP0005085_abnormal_gallbladder_physiolo4.41656260
5MP0005365_abnormal_bile_salt4.28004119
6MP0008875_abnormal_xenobiotic_pharmacok4.20365206
7MP0004019_abnormal_vitamin_homeostasis4.11999905
8MP0004043_abnormal_pH_regulation3.91375434
9MP0003252_abnormal_bile_duct3.26113565
10MP0002138_abnormal_hepatobiliary_system3.12936653
11MP0003806_abnormal_nucleotide_metabolis3.04700007
12MP0009643_abnormal_urine_homeostasis3.04303267
13MP0003195_calcinosis3.01738165
14MP0001765_abnormal_ion_homeostasis2.42182958
15MP0005636_abnormal_mineral_homeostasis2.36809958
16MP0001666_abnormal_nutrient_absorption2.35598053
17MP0010329_abnormal_lipoprotein_level2.07442964
18MP0005377_hearing/vestibular/ear_phenot2.04427114
19MP0003878_abnormal_ear_physiology2.04427114
20MP0001756_abnormal_urination2.00428433
21MP0002136_abnormal_kidney_physiology1.98495851
22MP0003186_abnormal_redox_activity1.83936303
23MP0005584_abnormal_enzyme/coenzyme_acti1.75058351
24MP0005319_abnormal_enzyme/_coenzyme1.74447449
25MP0009840_abnormal_foam_cell1.67910681
26MP0005083_abnormal_biliary_tract1.67546144
27MP0005058_abnormal_lysosome_morphology1.65771069
28MP0002118_abnormal_lipid_homeostasis1.55357080
29MP0005084_abnormal_gallbladder_morpholo1.53502949
30MP0010368_abnormal_lymphatic_system1.50855500
31MP0001764_abnormal_homeostasis1.46886985
32MP0003191_abnormal_cellular_cholesterol1.38852770
33MP0000609_abnormal_liver_physiology1.36825417
34MP0004885_abnormal_endolymph1.35977278
35MP0001958_emphysema1.32295819
36MP0005451_abnormal_body_composition1.26267911
37MP0006036_abnormal_mitochondrial_physio1.23470789
38MP0002876_abnormal_thyroid_physiology1.20742582
39MP0000538_abnormal_urinary_bladder1.20732923
40MP0005464_abnormal_platelet_physiology1.08241202
41MP0005670_abnormal_white_adipose1.06290630
42MP0003183_abnormal_peptide_metabolism1.03027006
43MP0005535_abnormal_body_temperature1.01333671
44MP0009764_decreased_sensitivity_to0.94976798
45MP0008961_abnormal_basal_metabolism0.92618230
46MP0004147_increased_porphyrin_level0.92443441
47MP0003705_abnormal_hypodermis_morpholog0.92082045
48MP0009642_abnormal_blood_homeostasis0.88009933
49MP0002928_abnormal_bile_duct0.87801599
50MP0003329_amyloid_beta_deposits0.87211933
51MP0009697_abnormal_copulation0.85736175
52MP0000598_abnormal_liver_morphology0.84103598
53MP0003868_abnormal_feces_composition0.81161704
54MP0000230_abnormal_systemic_arterial0.81084794
55MP0005220_abnormal_exocrine_pancreas0.80752128
56MP0002132_abnormal_respiratory_system0.79190293
57MP0005666_abnormal_adipose_tissue0.78382844
58MP0002089_abnormal_postnatal_growth/wei0.75541389
59MP0004264_abnormal_extraembryonic_tissu0.74151610
60MP0008469_abnormal_protein_level0.74100300
61MP0003300_gastrointestinal_ulcer0.73340404
62MP0002135_abnormal_kidney_morphology0.71891182
63MP0002638_abnormal_pupillary_reflex0.71781962
64MP0003638_abnormal_response/metabolism_0.70716348
65MP0002168_other_aberrant_phenotype0.69771821
66MP0002796_impaired_skin_barrier0.69028981
67MP0000604_amyloidosis0.67386842
68MP0005408_hypopigmentation0.66476085
69MP0002078_abnormal_glucose_homeostasis0.64939281
70MP0003172_abnormal_lysosome_physiology0.60383685
71MP0001270_distended_abdomen0.59965371
72MP0010234_abnormal_vibrissa_follicle0.59603902
73MP0003690_abnormal_glial_cell0.57738709
74MP0005647_abnormal_sex_gland0.57226651
75MP0001661_extended_life_span0.55272398
76MP0006035_abnormal_mitochondrial_morpho0.55268271
77MP0000249_abnormal_blood_vessel0.53686458
78MP0005376_homeostasis/metabolism_phenot0.53225060
79MP0009765_abnormal_xenobiotic_induced0.53157463
80MP0000534_abnormal_ureter_morphology0.53139786
81MP0005409_darkened_coat_color0.52382332
82MP0002896_abnormal_bone_mineralization0.52330432
83MP0009384_cardiac_valve_regurgitation0.50295574
84MP0003953_abnormal_hormone_level0.49969442
85MP0005395_other_phenotype0.49329568
86MP0005167_abnormal_blood-brain_barrier0.48529217
87MP0010386_abnormal_urinary_bladder0.47552880
88MP0002971_abnormal_brown_adipose0.47294268
89MP0009763_increased_sensitivity_to0.46236422
90MP0005266_abnormal_metabolism0.44310483
91MP0000371_diluted_coat_color0.43239406
92MP0005448_abnormal_energy_balance0.43033090
93MP0005501_abnormal_skin_physiology0.41834094
94MP0005165_increased_susceptibility_to0.41575446
95MP0002254_reproductive_system_inflammat0.40648470
96MP0008874_decreased_physiological_sensi0.39718392
97MP0000013_abnormal_adipose_tissue0.39511992
98MP0003075_altered_response_to0.39314265
99MP0001944_abnormal_pancreas_morphology0.38914619
100MP0001485_abnormal_pinna_reflex0.38862106
101MP0001879_abnormal_lymphatic_vessel0.38767352
102MP0000566_synostosis0.38575876
103MP0000747_muscle_weakness0.37543216
104MP0005166_decreased_susceptibility_to0.37478739
105MP0003646_muscle_fatigue0.36940444
106MP0001663_abnormal_digestive_system0.36566123
107MP0009053_abnormal_anal_canal0.36445474
108MP0003879_abnormal_hair_cell0.36363416
109MP0004272_abnormal_basement_membrane0.36254409
110MP0003656_abnormal_erythrocyte_physiolo0.35924326
111MP0002069_abnormal_eating/drinking_beha0.35230283
112MP0005334_abnormal_fat_pad0.35000973
113MP0003959_abnormal_lean_body0.34167011
114MP0004883_abnormal_blood_vessel0.33876127
115MP0004130_abnormal_muscle_cell0.33829078
116MP0002909_abnormal_adrenal_gland0.33732524
117MP0003011_delayed_dark_adaptation0.33615630
118MP0008872_abnormal_physiological_respon0.33565307
119MP0009672_abnormal_birth_weight0.33350429
120MP0003045_fibrosis0.32981719
121MP0005375_adipose_tissue_phenotype0.31994742
122MP0003943_abnormal_hepatobiliary_system0.31026222
123MP0002115_abnormal_skeleton_extremities0.29329112
124MP0005023_abnormal_wound_healing0.29313411
125MP0002098_abnormal_vibrissa_morphology0.28908884
126MP0009780_abnormal_chondrocyte_physiolo0.28807233
127MP0009115_abnormal_fat_cell0.28639416
128MP0001845_abnormal_inflammatory_respons0.28295568

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.36594718
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.45130928
3Hyperglycinuria (HP:0003108)5.41621830
4Increased circulating renin level (HP:0000848)5.28450443
5Metabolic alkalosis (HP:0200114)5.15992656
6Hypokalemic alkalosis (HP:0001949)5.12424560
7Proximal tubulopathy (HP:0000114)5.01401696
8Hyperactive renin-angiotensin system (HP:0000841)4.77578566
9Polyuria (HP:0000103)4.74028443
10Abnormality of glycine metabolism (HP:0010895)4.70278297
11Abnormality of serine family amino acid metabolism (HP:0010894)4.70278297
12Hypomagnesemia (HP:0002917)4.69844151
13Abnormality of purine metabolism (HP:0004352)4.68029159
14Prolonged partial thromboplastin time (HP:0003645)4.63026287
15Abnormal urine output (HP:0012590)4.61135578
16Hyperuricemia (HP:0002149)4.57671211
17Increased purine levels (HP:0004368)4.57671211
18Abnormality of renal excretion (HP:0011036)4.46333190
19Abnormality of aromatic amino acid family metabolism (HP:0004338)4.43472754
20Abnormality of chloride homeostasis (HP:0011422)4.43087178
21Generalized aminoaciduria (HP:0002909)4.31048284
22Ketosis (HP:0001946)4.23431703
23Alkalosis (HP:0001948)4.10638459
24Ketoacidosis (HP:0001993)4.08613531
25Potter facies (HP:0002009)4.05875700
26Facial shape deformation (HP:0011334)4.05875700
27Abnormality of complement system (HP:0005339)4.05555319
28Joint hemorrhage (HP:0005261)4.04227843
29Abnormality of magnesium homeostasis (HP:0004921)4.01994506
30Intrahepatic cholestasis (HP:0001406)3.93823441
31Hyperglycinemia (HP:0002154)3.92242891
32Abnormality of nucleobase metabolism (HP:0010932)3.84416034
33Systemic lupus erythematosus (HP:0002725)3.84103741
34Polydipsia (HP:0001959)3.79249390
35Abnormal drinking behavior (HP:0030082)3.79249390
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75969490
37Hyperammonemia (HP:0001987)3.67795491
38Abnormality of urine glucose concentration (HP:0011016)3.66338596
39Glycosuria (HP:0003076)3.66338596
40Xanthomatosis (HP:0000991)3.57162122
41Glomerulonephritis (HP:0000099)3.44837550
42Hydroxyprolinuria (HP:0003080)3.39212877
43Abnormality of proline metabolism (HP:0010907)3.39212877
44Abnormality of sulfur amino acid metabolism (HP:0004339)3.35352517
45Abnormality of renin-angiotensin system (HP:0000847)3.32342111
46Renal salt wasting (HP:0000127)3.28379478
47Delayed CNS myelination (HP:0002188)3.28214843
48Abnormality of monocarboxylic acid metabolism (HP:0010996)3.27151500
49Abnormality of fatty-acid metabolism (HP:0004359)3.26988806
50Hyperaldosteronism (HP:0000859)3.24714904
51Abnormality of the common coagulation pathway (HP:0010990)3.20402226
52Hyperphosphaturia (HP:0003109)3.14757852
53Vascular calcification (HP:0004934)3.10555762
54Hypolipoproteinemia (HP:0010981)3.04416094
55Tetany (HP:0001281)3.03605034
56Renal tubular acidosis (HP:0001947)3.03523892
57Dicarboxylic aciduria (HP:0003215)3.01991711
58Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01991711
59Hypercalciuria (HP:0002150)2.97265114
60Spontaneous abortion (HP:0005268)2.93059455
61Metabolic acidosis (HP:0001942)2.90952403
62Abnormal urine phosphate concentration (HP:0012599)2.87822321
63Nephrolithiasis (HP:0000787)2.86812155
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.80755314
65Rickets (HP:0002748)2.80706286
66Malnutrition (HP:0004395)2.76733456
67Cardiovascular calcification (HP:0011915)2.75356073
68Hypophosphatemia (HP:0002148)2.68707532
69Lethargy (HP:0001254)2.68064001
70Focal segmental glomerulosclerosis (HP:0000097)2.61863154
71Vomiting (HP:0002013)2.59633932
72Abnormal enzyme/coenzyme activity (HP:0012379)2.57679682
73Abnormality of serum amino acid levels (HP:0003112)2.57258987
74Enlarged kidneys (HP:0000105)2.52155028
75Delayed epiphyseal ossification (HP:0002663)2.51935618
76Hypoglycemic coma (HP:0001325)2.49552413
77Confusion (HP:0001289)2.49371030
78Hypokalemia (HP:0002900)2.48601528
79Sensorimotor neuropathy (HP:0007141)2.48520591
80Hypotension (HP:0002615)2.47526898
81Fat malabsorption (HP:0002630)2.44573386
82Nephritis (HP:0000123)2.43894505
83Abnormality of alkaline phosphatase activity (HP:0004379)2.43851491
84Deep venous thrombosis (HP:0002625)2.43048496
85Chondrocalcinosis (HP:0000934)2.42980081
86Adrenal overactivity (HP:0002717)2.42912707
87Methylmalonic aciduria (HP:0012120)2.41255156
88Gingival bleeding (HP:0000225)2.39795381
89Impaired platelet aggregation (HP:0003540)2.37077411
90Abnormal platelet function (HP:0011869)2.37077411
91Menorrhagia (HP:0000132)2.36918879
92Nephrocalcinosis (HP:0000121)2.36455521
93Irritability (HP:0000737)2.35786316
94Abnormality of Sharpey fibers (HP:0100685)2.32062916
95Abnormality of sodium homeostasis (HP:0010931)2.31100123
96Vacuolated lymphocytes (HP:0001922)2.30339755
97Abnormal tarsal ossification (HP:0008369)2.29632960
98Widely patent fontanelles and sutures (HP:0004492)2.29169578
99Neonatal onset (HP:0003623)2.29128658
100Osteomalacia (HP:0002749)2.26843610
101Purpura (HP:0000979)2.23423989
102Hemorrhage of the eye (HP:0011885)2.19818780
103Late onset (HP:0003584)2.19810036
104Glomerulosclerosis (HP:0000096)2.18251667
105Abnormality of pyrimidine metabolism (HP:0004353)2.17189785
106Abnormality of potassium homeostasis (HP:0011042)2.11858472
107Elevated alkaline phosphatase (HP:0003155)2.11018280
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10978299
109Recurrent gram-negative bacterial infections (HP:0005420)2.10272938
110Hypobetalipoproteinemia (HP:0003563)2.09791182
111Dehydration (HP:0001944)2.08914796
112Abnormality of vitamin metabolism (HP:0100508)2.08361052
113Hepatocellular carcinoma (HP:0001402)2.06511919
114Tubular atrophy (HP:0000092)2.05477520
115Nausea (HP:0002018)2.03136758
116Abnormality of the intrinsic pathway (HP:0010989)2.02501114
117Metaphyseal cupping (HP:0003021)2.01135951
118Spastic diplegia (HP:0001264)2.00773292
119Hypoalphalipoproteinemia (HP:0003233)2.00271778
120Abnormality of renal resorption (HP:0011038)1.97506386
121Cerebral edema (HP:0002181)1.96894456
122Hypercholesterolemia (HP:0003124)1.95402980
123Hyperbilirubinemia (HP:0002904)1.92830236
124Renal tubular dysfunction (HP:0000124)1.90391570
125Abnormality of methionine metabolism (HP:0010901)1.90160772
126Pancreatitis (HP:0001733)1.89652238
127Hypophosphatemic rickets (HP:0004912)1.89111270
128Hyperlipoproteinemia (HP:0010980)1.86891105
129Epidermoid cyst (HP:0200040)1.84112552
130Mitral stenosis (HP:0001718)1.84051220
131Complement deficiency (HP:0004431)1.83485003
132Protuberant abdomen (HP:0001538)1.79948321
133Hyponatremia (HP:0002902)1.77465856
134Thrombophlebitis (HP:0004418)1.77199253
135Conjugated hyperbilirubinemia (HP:0002908)1.77099182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.07726189
2WNK35.85947801
3OXSR15.72968980
4BCKDK5.55029935
5STK393.55221502
6STK38L2.68010159
7FGFR42.14843400
8ERN12.10601534
9PDK32.09253841
10PDK42.09253841
11NEK11.99013556
12MST1R1.96110655
13SGK4941.74731102
14SGK2231.74731102
15GRK61.61092280
16WNK11.59055712
17SIK11.42703297
18STK381.38863768
19PDK21.35606354
20PINK11.30802038
21TRIB31.28420915
22ACVR1B1.16649422
23FGFR31.16068962
24ERBB41.11065300
25INSRR1.08571658
26MAPK111.02632821
27EPHB10.99644819
28STK240.99060309
29SGK30.97897679
30MST40.94023543
31LATS10.93014130
32MAP3K70.92043933
33SGK20.92037880
34PTK60.91089699
35FRK0.85656626
36ABL20.83268488
37GSK3A0.81731218
38IRAK30.80734961
39MET0.80665416
40LRRK20.77845277
41NTRK30.74170765
42PTK20.72585966
43EPHA40.71065950
44PRKAA20.70201237
45DYRK1B0.66649742
46MAP2K40.65454943
47MUSK0.64743112
48PRKAA10.63559758
49PDPK10.62682704
50PIK3CA0.59557239
51MAP3K30.58523196
52LMTK20.58284559
53PRKCZ0.57933995
54MAPKAPK30.55335810
55KSR20.54019361
56RIPK10.53850671
57PRKG20.50075820
58SGK10.48810688
59TIE10.48138887
60MAPK120.47493513
61STK30.46760086
62CSF1R0.45202305
63MAPK150.45008728
64GRK10.44695223
65NLK0.42282934
66EPHA30.41775113
67PRKACG0.40567483
68BMX0.40417323
69IRAK20.39455100
70PDK10.39153685
71PAK30.38670888
72TGFBR20.37549146
73JAK20.36601760
74ILK0.36397045
75NTRK10.35648431
76PIK3CG0.34443490
77MAP3K140.33932815
78CAMKK20.33855407
79YES10.32589177
80MAP3K20.30721642
81FER0.30578488
82MAP2K20.30222979
83RET0.30170715
84PKN20.30147167
85SIK30.29739844
86SRC0.29710298
87TAOK30.28947541
88PRKCI0.28947007
89MAP2K60.28793604
90PTK2B0.28224708
91IRAK10.27194327
92ZAP700.27073403
93CAMK2G0.26813757
94MAPK40.26648730
95MAP3K110.26057511
96MAP3K120.25964103
97ADRBK20.25875793
98TEC0.25743617
99NME20.25637245
100KIT0.25623254
101PRKCB0.25594689
102FGR0.25242673
103PRKCA0.25207257
104PRKG10.25062939
105PRKCD0.24983250
106BMPR20.23624919
107TRPM70.23571959
108TAOK10.23566256
109TYK20.23217366
110NEK90.22647681
111ERBB20.22169463
112CSNK1A10.21932608
113PRKCG0.21434712
114BTK0.21034913
115MAP2K30.20826926
116DAPK20.20639116
117AKT20.20380059
118PAK40.20341068
119STK110.20315902
120PRKCQ0.18310100
121PRPF4B0.17650139
122PRKCH0.17246918
123JAK10.16636860
124PRKACA0.16578098
125KDR0.16495153
126MYLK0.16202109
127PDGFRA0.15899665
128MAP2K10.14658771
129MAP3K10.14541293
130BLK0.14501938
131IGF1R0.14117247
132CSK0.13600006
133NME10.13566644
134FGFR20.13190946
135PHKG10.12929190
136PHKG20.12929190
137TBK10.11186505

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60315215
2Butanoate metabolism_Homo sapiens_hsa006503.22432765
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.04139433
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.03065269
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93138229
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.85035783
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.81248731
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77343409
9Propanoate metabolism_Homo sapiens_hsa006402.66382236
10Fatty acid degradation_Homo sapiens_hsa000712.56886447
11Tryptophan metabolism_Homo sapiens_hsa003802.51008867
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50171115
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48733844
14Peroxisome_Homo sapiens_hsa041462.46541258
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42446838
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16846239
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12018109
18Pyruvate metabolism_Homo sapiens_hsa006202.11159614
19Nitrogen metabolism_Homo sapiens_hsa009102.09031066
20Arginine biosynthesis_Homo sapiens_hsa002202.03349133
21Fatty acid metabolism_Homo sapiens_hsa012121.93810091
22beta-Alanine metabolism_Homo sapiens_hsa004101.86420126
23Sulfur metabolism_Homo sapiens_hsa009201.84576333
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81989090
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78109091
26Vitamin digestion and absorption_Homo sapiens_hsa049771.74333447
27Bile secretion_Homo sapiens_hsa049761.62788589
28Histidine metabolism_Homo sapiens_hsa003401.58514902
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55765681
30PPAR signaling pathway_Homo sapiens_hsa033201.55007202
31Carbon metabolism_Homo sapiens_hsa012001.52078907
32Starch and sucrose metabolism_Homo sapiens_hsa005001.48996439
33Arginine and proline metabolism_Homo sapiens_hsa003301.45471427
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39185226
35Linoleic acid metabolism_Homo sapiens_hsa005911.38208934
36Glutathione metabolism_Homo sapiens_hsa004801.35619101
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.33645848
38Folate biosynthesis_Homo sapiens_hsa007901.33521916
39Selenocompound metabolism_Homo sapiens_hsa004501.33262010
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30432717
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.24040863
42Chemical carcinogenesis_Homo sapiens_hsa052041.23984258
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21323047
44Phenylalanine metabolism_Homo sapiens_hsa003601.20273104
45Biosynthesis of amino acids_Homo sapiens_hsa012301.15759550
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05757871
47Retinol metabolism_Homo sapiens_hsa008301.05700454
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.01402824
49Lysine degradation_Homo sapiens_hsa003101.01307536
50Fatty acid elongation_Homo sapiens_hsa000621.00031842
51Glycerolipid metabolism_Homo sapiens_hsa005610.98846444
52Complement and coagulation cascades_Homo sapiens_hsa046100.98501324
53Steroid biosynthesis_Homo sapiens_hsa001000.89843217
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.88453722
55Collecting duct acid secretion_Homo sapiens_hsa049660.87311844
56Caffeine metabolism_Homo sapiens_hsa002320.84980511
57Fructose and mannose metabolism_Homo sapiens_hsa000510.83610892
58Fat digestion and absorption_Homo sapiens_hsa049750.80189388
59Mineral absorption_Homo sapiens_hsa049780.79452735
60Protein digestion and absorption_Homo sapiens_hsa049740.77736790
61Tyrosine metabolism_Homo sapiens_hsa003500.77401210
62Prion diseases_Homo sapiens_hsa050200.74583523
63Pentose phosphate pathway_Homo sapiens_hsa000300.72836348
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69124791
65Sulfur relay system_Homo sapiens_hsa041220.67470008
66Other glycan degradation_Homo sapiens_hsa005110.62133321
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62046022
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61439211
69ABC transporters_Homo sapiens_hsa020100.59515888
70Metabolic pathways_Homo sapiens_hsa011000.57330165
71Renin-angiotensin system_Homo sapiens_hsa046140.51862088
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47549760
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43189186
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41609820
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38913788
76Galactose metabolism_Homo sapiens_hsa000520.35085735
77Staphylococcus aureus infection_Homo sapiens_hsa051500.32648655
78One carbon pool by folate_Homo sapiens_hsa006700.31038314
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.29647010
80Oxidative phosphorylation_Homo sapiens_hsa001900.26795727
81Vitamin B6 metabolism_Homo sapiens_hsa007500.25673115
82Lysosome_Homo sapiens_hsa041420.25092325
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23992441
84Thyroid hormone synthesis_Homo sapiens_hsa049180.23930179
85Arachidonic acid metabolism_Homo sapiens_hsa005900.22818807
86Fatty acid biosynthesis_Homo sapiens_hsa000610.22780835
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19705673
88Ether lipid metabolism_Homo sapiens_hsa005650.18158526
89Pertussis_Homo sapiens_hsa051330.16014838
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.12612730
91Insulin resistance_Homo sapiens_hsa049310.11139487
92Parkinsons disease_Homo sapiens_hsa050120.06947995
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06770856
94Serotonergic synapse_Homo sapiens_hsa047260.05027021
95Hepatitis C_Homo sapiens_hsa05160-0.1432621
96Vibrio cholerae infection_Homo sapiens_hsa05110-0.1288079
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.1144728
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1085329
99Choline metabolism in cancer_Homo sapiens_hsa05231-0.1058595
100Alzheimers disease_Homo sapiens_hsa05010-0.0800288
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0642254
102Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0641367
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0508580
104Platelet activation_Homo sapiens_hsa04611-0.0478925
105Pancreatic secretion_Homo sapiens_hsa04972-0.0466523
106Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0435602
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0420120
108Gastric acid secretion_Homo sapiens_hsa04971-0.0411518
109AMPK signaling pathway_Homo sapiens_hsa04152-0.0400186
110Sphingolipid metabolism_Homo sapiens_hsa00600-0.0042565
111Glucagon signaling pathway_Homo sapiens_hsa04922-0.0030636

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