Rank | Gene Set | Z-score |
---|---|---|
1 | drug transmembrane transport (GO:0006855) | 8.50518405 |
2 | urate metabolic process (GO:0046415) | 8.42861216 |
3 | glyoxylate metabolic process (GO:0046487) | 7.24640592 |
4 | aminoglycoside antibiotic metabolic process (GO:0030647) | 7.19799462 |
5 | drug transport (GO:0015893) | 7.18922407 |
6 | lysine metabolic process (GO:0006553) | 7.13846566 |
7 | lysine catabolic process (GO:0006554) | 7.13846566 |
8 | cysteine metabolic process (GO:0006534) | 6.92986742 |
9 | epoxygenase P450 pathway (GO:0019373) | 6.82050840 |
10 | exogenous drug catabolic process (GO:0042738) | 6.74338142 |
11 | drug catabolic process (GO:0042737) | 6.71482991 |
12 | L-phenylalanine catabolic process (GO:0006559) | 6.45821163 |
13 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.45821163 |
14 | negative regulation of cholesterol transport (GO:0032375) | 6.45217775 |
15 | negative regulation of sterol transport (GO:0032372) | 6.45217775 |
16 | L-phenylalanine metabolic process (GO:0006558) | 6.39320679 |
17 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.39320679 |
18 | organic cation transport (GO:0015695) | 6.26608059 |
19 | aromatic amino acid family catabolic process (GO:0009074) | 5.97862125 |
20 | phosphate ion transport (GO:0006817) | 5.95794196 |
21 | regulation of fibrinolysis (GO:0051917) | 5.91999126 |
22 | negative regulation of fibrinolysis (GO:0051918) | 5.85759550 |
23 | regulation of protein activation cascade (GO:2000257) | 5.81275913 |
24 | complement activation, alternative pathway (GO:0006957) | 5.75474568 |
25 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 5.66917617 |
26 | omega-hydroxylase P450 pathway (GO:0097267) | 5.64929685 |
27 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.63457799 |
28 | tryptophan catabolic process (GO:0006569) | 5.60181334 |
29 | indole-containing compound catabolic process (GO:0042436) | 5.60181334 |
30 | indolalkylamine catabolic process (GO:0046218) | 5.60181334 |
31 | regulation of complement activation (GO:0030449) | 5.55857760 |
32 | serine family amino acid catabolic process (GO:0009071) | 5.50245661 |
33 | high-density lipoprotein particle remodeling (GO:0034375) | 5.45628520 |
34 | homocysteine metabolic process (GO:0050667) | 5.43643022 |
35 | regulation of cholesterol esterification (GO:0010872) | 5.41120192 |
36 | cellular modified amino acid catabolic process (GO:0042219) | 5.33494160 |
37 | blood coagulation, intrinsic pathway (GO:0007597) | 5.29798170 |
38 | tryptophan metabolic process (GO:0006568) | 5.28376518 |
39 | short-chain fatty acid metabolic process (GO:0046459) | 5.24327552 |
40 | quaternary ammonium group transport (GO:0015697) | 5.22034031 |
41 | aspartate family amino acid catabolic process (GO:0009068) | 5.14881334 |
42 | serine family amino acid metabolic process (GO:0009069) | 5.09216692 |
43 | phospholipid efflux (GO:0033700) | 5.09154570 |
44 | phosphate ion transmembrane transport (GO:0035435) | 5.07020896 |
45 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.04807544 |
46 | protein carboxylation (GO:0018214) | 5.04807544 |
47 | response to mercury ion (GO:0046689) | 5.04300351 |
48 | metanephric nephron tubule development (GO:0072234) | 4.98384007 |
49 | metanephric tubule development (GO:0072170) | 4.98384007 |
50 | reverse cholesterol transport (GO:0043691) | 4.94400155 |
51 | sulfur amino acid catabolic process (GO:0000098) | 4.89175497 |
52 | fibrinolysis (GO:0042730) | 4.81897074 |
53 | tricarboxylic acid metabolic process (GO:0072350) | 4.81739434 |
54 | amino-acid betaine metabolic process (GO:0006577) | 4.79065730 |
55 | nonribosomal peptide biosynthetic process (GO:0019184) | 4.78258079 |
56 | protein-lipid complex remodeling (GO:0034368) | 4.77988960 |
57 | macromolecular complex remodeling (GO:0034367) | 4.77988960 |
58 | plasma lipoprotein particle remodeling (GO:0034369) | 4.77988960 |
59 | branched-chain amino acid metabolic process (GO:0009081) | 4.68813526 |
60 | serine family amino acid biosynthetic process (GO:0009070) | 4.67668035 |
61 | metanephric nephron epithelium development (GO:0072243) | 4.64215197 |
62 | kynurenine metabolic process (GO:0070189) | 4.54396971 |
63 | regulation of triglyceride catabolic process (GO:0010896) | 4.49726207 |
64 | alpha-amino acid catabolic process (GO:1901606) | 4.46683930 |
65 | cellular amino acid catabolic process (GO:0009063) | 4.44367160 |
66 | aromatic amino acid family metabolic process (GO:0009072) | 4.40670945 |
67 | valine metabolic process (GO:0006573) | 4.40344501 |
68 | bile acid biosynthetic process (GO:0006699) | 4.39727374 |
69 | cholesterol efflux (GO:0033344) | 4.37616281 |
70 | glutathione biosynthetic process (GO:0006750) | 4.34814212 |
71 | cellular ketone body metabolic process (GO:0046950) | 4.33543905 |
72 | proline metabolic process (GO:0006560) | 4.28673822 |
73 | fatty acid beta-oxidation (GO:0006635) | 4.28575602 |
74 | glutamate metabolic process (GO:0006536) | 4.26778642 |
75 | fructose metabolic process (GO:0006000) | 4.25959344 |
76 | metanephric epithelium development (GO:0072207) | 4.23552944 |
77 | acylglycerol homeostasis (GO:0055090) | 4.22827971 |
78 | triglyceride homeostasis (GO:0070328) | 4.22827971 |
79 | flavonoid metabolic process (GO:0009812) | 4.22117800 |
80 | cellular glucuronidation (GO:0052695) | 4.20962414 |
81 | negative regulation of hemostasis (GO:1900047) | 4.19826220 |
82 | negative regulation of blood coagulation (GO:0030195) | 4.19826220 |
83 | glucuronate metabolic process (GO:0019585) | 4.17982319 |
84 | uronic acid metabolic process (GO:0006063) | 4.17982319 |
85 | very-low-density lipoprotein particle assembly (GO:0034379) | 4.16910446 |
86 | plasma lipoprotein particle assembly (GO:0034377) | 4.15231389 |
87 | branched-chain amino acid catabolic process (GO:0009083) | 4.14097519 |
88 | 2-oxoglutarate metabolic process (GO:0006103) | 4.12286822 |
89 | polyol transport (GO:0015791) | 4.11692212 |
90 | ethanol metabolic process (GO:0006067) | 4.09943695 |
91 | acetyl-CoA metabolic process (GO:0006084) | 4.09576417 |
92 | fatty acid oxidation (GO:0019395) | 4.07827404 |
93 | regulation of plasminogen activation (GO:0010755) | 4.07243408 |
94 | S-adenosylmethionine metabolic process (GO:0046500) | 4.06556964 |
95 | lipid oxidation (GO:0034440) | 4.02828900 |
96 | carnitine metabolic process (GO:0009437) | 3.97953356 |
97 | carboxylic acid catabolic process (GO:0046395) | 3.95746738 |
98 | organic acid catabolic process (GO:0016054) | 3.95746738 |
99 | indolalkylamine metabolic process (GO:0006586) | 3.92956907 |
100 | protein activation cascade (GO:0072376) | 3.91468204 |
101 | benzene-containing compound metabolic process (GO:0042537) | 3.88765463 |
102 | negative regulation of coagulation (GO:0050819) | 3.85727378 |
103 | carnitine transport (GO:0015879) | 3.84648265 |
104 | amino-acid betaine transport (GO:0015838) | 3.84648265 |
105 | fatty acid catabolic process (GO:0009062) | 3.82848397 |
106 | plasma lipoprotein particle clearance (GO:0034381) | 3.80930370 |
107 | vitamin D metabolic process (GO:0042359) | 3.80794584 |
108 | low-density lipoprotein particle remodeling (GO:0034374) | 3.80677954 |
109 | excretion (GO:0007588) | 3.79579696 |
110 | modified amino acid transport (GO:0072337) | 3.79480396 |
111 | drug metabolic process (GO:0017144) | 3.78795835 |
112 | negative regulation of lipase activity (GO:0060192) | 3.78523048 |
113 | cellular biogenic amine catabolic process (GO:0042402) | 3.78393513 |
114 | amine catabolic process (GO:0009310) | 3.78393513 |
115 | ketone body metabolic process (GO:1902224) | 3.74619675 |
116 | monocarboxylic acid catabolic process (GO:0072329) | 3.73720636 |
117 | bile acid and bile salt transport (GO:0015721) | 3.72263193 |
118 | phosphate ion homeostasis (GO:0055062) | 3.71962004 |
119 | trivalent inorganic anion homeostasis (GO:0072506) | 3.71962004 |
120 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.71822779 |
121 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.71822779 |
122 | plasma lipoprotein particle organization (GO:0071827) | 3.71716098 |
123 | renal absorption (GO:0070293) | 3.69235629 |
124 | negative regulation of wound healing (GO:0061045) | 3.68277194 |
125 | protein-lipid complex assembly (GO:0065005) | 3.67793896 |
126 | phospholipid homeostasis (GO:0055091) | 3.66501746 |
127 | alpha-linolenic acid metabolic process (GO:0036109) | 3.66483432 |
128 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.64603640 |
129 | aldehyde catabolic process (GO:0046185) | 3.61709943 |
130 | indole-containing compound metabolic process (GO:0042430) | 3.58727637 |
131 | toxin transport (GO:1901998) | 3.58264175 |
132 | response to phenylpropanoid (GO:0080184) | 3.58191508 |
133 | regulation of cholesterol homeostasis (GO:2000188) | 3.55990481 |
134 | glycine metabolic process (GO:0006544) | 3.54741060 |
135 | coenzyme catabolic process (GO:0009109) | 3.54423431 |
136 | phenylpropanoid metabolic process (GO:0009698) | 3.53325537 |
137 | ethanol oxidation (GO:0006069) | 3.52863421 |
138 | oxidative demethylation (GO:0070989) | 3.52414730 |
139 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.52297455 |
140 | urea metabolic process (GO:0019627) | 3.52038773 |
141 | urea cycle (GO:0000050) | 3.52038773 |
142 | protein-lipid complex subunit organization (GO:0071825) | 3.48478392 |
143 | nephron tubule development (GO:0072080) | 3.47637397 |
144 | peptide biosynthetic process (GO:0043043) | 3.47268854 |
145 | bile acid metabolic process (GO:0008206) | 3.46414688 |
146 | glutathione derivative biosynthetic process (GO:1901687) | 3.45990457 |
147 | glutathione derivative metabolic process (GO:1901685) | 3.45990457 |
148 | dicarboxylic acid metabolic process (GO:0043648) | 3.44257774 |
149 | regulation of humoral immune response (GO:0002920) | 3.42028057 |
150 | complement activation, classical pathway (GO:0006958) | 3.41213665 |
151 | small molecule catabolic process (GO:0044282) | 3.41189415 |
152 | tyrosine metabolic process (GO:0006570) | 3.40994425 |
153 | lipoprotein metabolic process (GO:0042157) | 3.40421974 |
154 | negative regulation of protein activation cascade (GO:2000258) | 3.40233748 |
155 | negative regulation of lipid transport (GO:0032369) | 3.37933444 |
156 | nitrogen cycle metabolic process (GO:0071941) | 3.35327802 |
157 | complement activation (GO:0006956) | 3.35048939 |
158 | imidazole-containing compound metabolic process (GO:0052803) | 3.34694318 |
159 | sulfur amino acid metabolic process (GO:0000096) | 3.32098131 |
160 | sodium-independent organic anion transport (GO:0043252) | 3.32038160 |
161 | actin filament depolymerization (GO:0030042) | 3.31927437 |
162 | positive regulation of blood coagulation (GO:0030194) | 3.30759855 |
163 | positive regulation of hemostasis (GO:1900048) | 3.30759855 |
164 | peptide catabolic process (GO:0043171) | 3.29604381 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 9.73109408 |
2 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.16776151 |
3 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.18461196 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.40153246 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.78423879 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.78234656 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.78238960 |
8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.14750687 |
9 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.92668622 |
10 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.85745556 |
11 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.63069039 |
12 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.57621295 |
13 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.11913198 |
14 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.11444208 |
15 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.93162909 |
16 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.87019847 |
17 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.86649723 |
18 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.65466620 |
19 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.65216979 |
20 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.62722362 |
21 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.56891687 |
22 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.54252568 |
23 | * CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.54125939 |
24 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.53761483 |
25 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.52633139 |
26 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.52452533 |
27 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41539206 |
28 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.40239679 |
29 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.38743860 |
30 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.35830154 |
31 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.28677582 |
32 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.22712527 |
33 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.22183449 |
34 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.21427257 |
35 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.19131216 |
36 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.14866478 |
37 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.13220046 |
38 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.13111439 |
39 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.11409832 |
40 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.00108497 |
41 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.99130151 |
42 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.97824147 |
43 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.95494977 |
44 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.95476958 |
45 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.95246924 |
46 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.93914022 |
47 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.93584358 |
48 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.93319131 |
49 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.92939015 |
50 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.92752027 |
51 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.91581325 |
52 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.90909841 |
53 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.90156015 |
54 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.89972598 |
55 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.89130260 |
56 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.88848570 |
57 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.88574696 |
58 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.88103957 |
59 | NFYA_21822215_ChIP-Seq_K562_Human | 0.86048430 |
60 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.83801294 |
61 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.83278509 |
62 | GATA1_19941826_ChIP-Seq_K562_Human | 0.82761371 |
63 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.82537959 |
64 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.82264563 |
65 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82133641 |
66 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.81090301 |
67 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.78969935 |
68 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.77819005 |
69 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.77289322 |
70 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.77231539 |
71 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.77124634 |
72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.75272877 |
73 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.74942615 |
74 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.73871473 |
75 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.73799730 |
76 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.73446913 |
77 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.72770733 |
78 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.72482923 |
79 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.72410765 |
80 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.71910362 |
81 | AR_20517297_ChIP-Seq_VCAP_Human | 0.71096938 |
82 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.70778466 |
83 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.69902645 |
84 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.69749718 |
85 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.69672255 |
86 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.68930626 |
87 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.68424911 |
88 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.68157004 |
89 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.67874336 |
90 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.67663481 |
91 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.66596887 |
92 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.66596887 |
93 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.66328234 |
94 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.65125030 |
95 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.64970157 |
96 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.64969828 |
97 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.64937240 |
98 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.64670349 |
99 | NFYB_21822215_ChIP-Seq_K562_Human | 0.63967054 |
100 | * ETV1_20927104_ChIP-Seq_GIST48_Human | 0.63878930 |
101 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.63423133 |
102 | PU1_27457419_Chip-Seq_LIVER_Mouse | 0.63163480 |
103 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.62887107 |
104 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.62685430 |
105 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.62525767 |
106 | CBP_21632823_ChIP-Seq_H3396_Human | 0.62332579 |
107 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.61485567 |
108 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.61173417 |
109 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.61070402 |
110 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.60718053 |
111 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.60569861 |
112 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.60569861 |
113 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.60534580 |
114 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.60498271 |
115 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.60483334 |
116 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.60429778 |
117 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.60252736 |
118 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.59267957 |
119 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.59262359 |
120 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.59109449 |
121 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.58979481 |
122 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.58304250 |
123 | GATA2_19941826_ChIP-Seq_K562_Human | 0.57507479 |
124 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.57254588 |
125 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.57246847 |
126 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.57063933 |
127 | GATA1_22025678_ChIP-Seq_K562_Human | 0.56474923 |
128 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.56064011 |
129 | * KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.55549794 |
130 | RXR_22108803_ChIP-Seq_LS180_Human | 0.55435997 |
131 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.55015243 |
132 | * ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.54522180 |
133 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.54138491 |
134 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.53881104 |
135 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.53789265 |
136 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.53316911 |
137 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.53214847 |
138 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.52331014 |
139 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.52154316 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005360_urolithiasis | 8.67499516 |
2 | MP0002139_abnormal_hepatobiliary_system | 6.99558849 |
3 | MP0005332_abnormal_amino_acid | 4.56330370 |
4 | MP0005085_abnormal_gallbladder_physiolo | 4.41656260 |
5 | MP0005365_abnormal_bile_salt | 4.28004119 |
6 | MP0008875_abnormal_xenobiotic_pharmacok | 4.20365206 |
7 | MP0004019_abnormal_vitamin_homeostasis | 4.11999905 |
8 | MP0004043_abnormal_pH_regulation | 3.91375434 |
9 | MP0003252_abnormal_bile_duct | 3.26113565 |
10 | MP0002138_abnormal_hepatobiliary_system | 3.12936653 |
11 | MP0003806_abnormal_nucleotide_metabolis | 3.04700007 |
12 | MP0009643_abnormal_urine_homeostasis | 3.04303267 |
13 | MP0003195_calcinosis | 3.01738165 |
14 | MP0001765_abnormal_ion_homeostasis | 2.42182958 |
15 | MP0005636_abnormal_mineral_homeostasis | 2.36809958 |
16 | MP0001666_abnormal_nutrient_absorption | 2.35598053 |
17 | MP0010329_abnormal_lipoprotein_level | 2.07442964 |
18 | MP0003878_abnormal_ear_physiology | 2.04427114 |
19 | MP0005377_hearing/vestibular/ear_phenot | 2.04427114 |
20 | MP0001756_abnormal_urination | 2.00428433 |
21 | MP0002136_abnormal_kidney_physiology | 1.98495851 |
22 | MP0003186_abnormal_redox_activity | 1.83936303 |
23 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.75058351 |
24 | MP0005319_abnormal_enzyme/_coenzyme | 1.74447449 |
25 | MP0009840_abnormal_foam_cell | 1.67910681 |
26 | MP0005083_abnormal_biliary_tract | 1.67546144 |
27 | MP0005058_abnormal_lysosome_morphology | 1.65771069 |
28 | MP0002118_abnormal_lipid_homeostasis | 1.55357080 |
29 | MP0005084_abnormal_gallbladder_morpholo | 1.53502949 |
30 | MP0010368_abnormal_lymphatic_system | 1.50855500 |
31 | MP0001764_abnormal_homeostasis | 1.46886985 |
32 | MP0003191_abnormal_cellular_cholesterol | 1.38852770 |
33 | MP0000609_abnormal_liver_physiology | 1.36825417 |
34 | MP0004885_abnormal_endolymph | 1.35977278 |
35 | MP0001958_emphysema | 1.32295819 |
36 | MP0005451_abnormal_body_composition | 1.26267911 |
37 | MP0006036_abnormal_mitochondrial_physio | 1.23470789 |
38 | MP0002876_abnormal_thyroid_physiology | 1.20742582 |
39 | MP0000538_abnormal_urinary_bladder | 1.20732923 |
40 | MP0005464_abnormal_platelet_physiology | 1.08241202 |
41 | MP0005670_abnormal_white_adipose | 1.06290630 |
42 | MP0003183_abnormal_peptide_metabolism | 1.03027006 |
43 | MP0005535_abnormal_body_temperature | 1.01333671 |
44 | MP0009764_decreased_sensitivity_to | 0.94976798 |
45 | MP0008961_abnormal_basal_metabolism | 0.92618230 |
46 | MP0004147_increased_porphyrin_level | 0.92443441 |
47 | MP0003705_abnormal_hypodermis_morpholog | 0.92082045 |
48 | MP0009642_abnormal_blood_homeostasis | 0.88009933 |
49 | MP0002928_abnormal_bile_duct | 0.87801599 |
50 | MP0003329_amyloid_beta_deposits | 0.87211933 |
51 | MP0009697_abnormal_copulation | 0.85736175 |
52 | MP0000598_abnormal_liver_morphology | 0.84103598 |
53 | MP0003868_abnormal_feces_composition | 0.81161704 |
54 | MP0000230_abnormal_systemic_arterial | 0.81084794 |
55 | MP0005220_abnormal_exocrine_pancreas | 0.80752128 |
56 | MP0002132_abnormal_respiratory_system | 0.79190293 |
57 | MP0005666_abnormal_adipose_tissue | 0.78382844 |
58 | MP0002089_abnormal_postnatal_growth/wei | 0.75541389 |
59 | MP0004264_abnormal_extraembryonic_tissu | 0.74151610 |
60 | MP0008469_abnormal_protein_level | 0.74100300 |
61 | MP0003300_gastrointestinal_ulcer | 0.73340404 |
62 | MP0002135_abnormal_kidney_morphology | 0.71891182 |
63 | MP0002638_abnormal_pupillary_reflex | 0.71781962 |
64 | MP0003638_abnormal_response/metabolism_ | 0.70716348 |
65 | MP0002168_other_aberrant_phenotype | 0.69771821 |
66 | MP0002796_impaired_skin_barrier | 0.69028981 |
67 | MP0000604_amyloidosis | 0.67386842 |
68 | MP0005408_hypopigmentation | 0.66476085 |
69 | MP0002078_abnormal_glucose_homeostasis | 0.64939281 |
70 | MP0003172_abnormal_lysosome_physiology | 0.60383685 |
71 | MP0001270_distended_abdomen | 0.59965371 |
72 | MP0010234_abnormal_vibrissa_follicle | 0.59603902 |
73 | MP0003690_abnormal_glial_cell | 0.57738709 |
74 | MP0005647_abnormal_sex_gland | 0.57226651 |
75 | MP0001661_extended_life_span | 0.55272398 |
76 | MP0006035_abnormal_mitochondrial_morpho | 0.55268271 |
77 | MP0000249_abnormal_blood_vessel | 0.53686458 |
78 | MP0005376_homeostasis/metabolism_phenot | 0.53225060 |
79 | MP0009765_abnormal_xenobiotic_induced | 0.53157463 |
80 | MP0000534_abnormal_ureter_morphology | 0.53139786 |
81 | MP0005409_darkened_coat_color | 0.52382332 |
82 | MP0002896_abnormal_bone_mineralization | 0.52330432 |
83 | MP0009384_cardiac_valve_regurgitation | 0.50295574 |
84 | MP0003953_abnormal_hormone_level | 0.49969442 |
85 | MP0005395_other_phenotype | 0.49329568 |
86 | MP0005167_abnormal_blood-brain_barrier | 0.48529217 |
87 | MP0010386_abnormal_urinary_bladder | 0.47552880 |
88 | MP0002971_abnormal_brown_adipose | 0.47294268 |
89 | MP0009763_increased_sensitivity_to | 0.46236422 |
90 | MP0005266_abnormal_metabolism | 0.44310483 |
91 | MP0000371_diluted_coat_color | 0.43239406 |
92 | MP0005448_abnormal_energy_balance | 0.43033090 |
93 | MP0005501_abnormal_skin_physiology | 0.41834094 |
94 | MP0005165_increased_susceptibility_to | 0.41575446 |
95 | MP0002254_reproductive_system_inflammat | 0.40648470 |
96 | MP0008874_decreased_physiological_sensi | 0.39718392 |
97 | MP0000013_abnormal_adipose_tissue | 0.39511992 |
98 | MP0003075_altered_response_to | 0.39314265 |
99 | MP0001944_abnormal_pancreas_morphology | 0.38914619 |
100 | MP0001485_abnormal_pinna_reflex | 0.38862106 |
101 | MP0001879_abnormal_lymphatic_vessel | 0.38767352 |
102 | MP0000566_synostosis | 0.38575876 |
103 | MP0000747_muscle_weakness | 0.37543216 |
104 | MP0005166_decreased_susceptibility_to | 0.37478739 |
105 | MP0003646_muscle_fatigue | 0.36940444 |
106 | MP0001663_abnormal_digestive_system | 0.36566123 |
107 | MP0009053_abnormal_anal_canal | 0.36445474 |
108 | MP0003879_abnormal_hair_cell | 0.36363416 |
109 | MP0004272_abnormal_basement_membrane | 0.36254409 |
110 | MP0003656_abnormal_erythrocyte_physiolo | 0.35924326 |
111 | MP0002069_abnormal_eating/drinking_beha | 0.35230283 |
112 | MP0005334_abnormal_fat_pad | 0.35000973 |
113 | MP0003959_abnormal_lean_body | 0.34167011 |
114 | MP0004883_abnormal_blood_vessel | 0.33876127 |
115 | MP0004130_abnormal_muscle_cell | 0.33829078 |
116 | MP0002909_abnormal_adrenal_gland | 0.33732524 |
117 | MP0003011_delayed_dark_adaptation | 0.33615630 |
118 | MP0008872_abnormal_physiological_respon | 0.33565307 |
119 | MP0009672_abnormal_birth_weight | 0.33350429 |
120 | MP0003045_fibrosis | 0.32981719 |
121 | MP0005375_adipose_tissue_phenotype | 0.31994742 |
122 | MP0003943_abnormal_hepatobiliary_system | 0.31026222 |
123 | MP0002115_abnormal_skeleton_extremities | 0.29329112 |
124 | MP0005023_abnormal_wound_healing | 0.29313411 |
125 | MP0002098_abnormal_vibrissa_morphology | 0.28908884 |
126 | MP0009780_abnormal_chondrocyte_physiolo | 0.28807233 |
127 | MP0009115_abnormal_fat_cell | 0.28639416 |
128 | MP0001845_abnormal_inflammatory_respons | 0.28295568 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Gout (HP:0001997) | 6.36594718 |
2 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 5.45130928 |
3 | Hyperglycinuria (HP:0003108) | 5.41621830 |
4 | Increased circulating renin level (HP:0000848) | 5.28450443 |
5 | Metabolic alkalosis (HP:0200114) | 5.15992656 |
6 | Hypokalemic alkalosis (HP:0001949) | 5.12424560 |
7 | Proximal tubulopathy (HP:0000114) | 5.01401696 |
8 | Hyperactive renin-angiotensin system (HP:0000841) | 4.77578566 |
9 | Polyuria (HP:0000103) | 4.74028443 |
10 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.70278297 |
11 | Abnormality of glycine metabolism (HP:0010895) | 4.70278297 |
12 | Hypomagnesemia (HP:0002917) | 4.69844151 |
13 | Abnormality of purine metabolism (HP:0004352) | 4.68029159 |
14 | Prolonged partial thromboplastin time (HP:0003645) | 4.63026287 |
15 | Abnormal urine output (HP:0012590) | 4.61135578 |
16 | Hyperuricemia (HP:0002149) | 4.57671211 |
17 | Increased purine levels (HP:0004368) | 4.57671211 |
18 | Abnormality of renal excretion (HP:0011036) | 4.46333190 |
19 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.43472754 |
20 | Abnormality of chloride homeostasis (HP:0011422) | 4.43087178 |
21 | Generalized aminoaciduria (HP:0002909) | 4.31048284 |
22 | Ketosis (HP:0001946) | 4.23431703 |
23 | Alkalosis (HP:0001948) | 4.10638459 |
24 | Ketoacidosis (HP:0001993) | 4.08613531 |
25 | Facial shape deformation (HP:0011334) | 4.05875700 |
26 | Potter facies (HP:0002009) | 4.05875700 |
27 | Abnormality of complement system (HP:0005339) | 4.05555319 |
28 | Joint hemorrhage (HP:0005261) | 4.04227843 |
29 | Abnormality of magnesium homeostasis (HP:0004921) | 4.01994506 |
30 | Intrahepatic cholestasis (HP:0001406) | 3.93823441 |
31 | Hyperglycinemia (HP:0002154) | 3.92242891 |
32 | Abnormality of nucleobase metabolism (HP:0010932) | 3.84416034 |
33 | Systemic lupus erythematosus (HP:0002725) | 3.84103741 |
34 | Abnormal drinking behavior (HP:0030082) | 3.79249390 |
35 | Polydipsia (HP:0001959) | 3.79249390 |
36 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.75969490 |
37 | Hyperammonemia (HP:0001987) | 3.67795491 |
38 | Abnormality of urine glucose concentration (HP:0011016) | 3.66338596 |
39 | Glycosuria (HP:0003076) | 3.66338596 |
40 | Xanthomatosis (HP:0000991) | 3.57162122 |
41 | Glomerulonephritis (HP:0000099) | 3.44837550 |
42 | Hydroxyprolinuria (HP:0003080) | 3.39212877 |
43 | Abnormality of proline metabolism (HP:0010907) | 3.39212877 |
44 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.35352517 |
45 | Abnormality of renin-angiotensin system (HP:0000847) | 3.32342111 |
46 | Renal salt wasting (HP:0000127) | 3.28379478 |
47 | Delayed CNS myelination (HP:0002188) | 3.28214843 |
48 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.27151500 |
49 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.26988806 |
50 | Hyperaldosteronism (HP:0000859) | 3.24714904 |
51 | Abnormality of the common coagulation pathway (HP:0010990) | 3.20402226 |
52 | Hyperphosphaturia (HP:0003109) | 3.14757852 |
53 | Vascular calcification (HP:0004934) | 3.10555762 |
54 | Hypolipoproteinemia (HP:0010981) | 3.04416094 |
55 | Tetany (HP:0001281) | 3.03605034 |
56 | Renal tubular acidosis (HP:0001947) | 3.03523892 |
57 | Dicarboxylic aciduria (HP:0003215) | 3.01991711 |
58 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.01991711 |
59 | Hypercalciuria (HP:0002150) | 2.97265114 |
60 | Spontaneous abortion (HP:0005268) | 2.93059455 |
61 | Metabolic acidosis (HP:0001942) | 2.90952403 |
62 | Abnormal urine phosphate concentration (HP:0012599) | 2.87822321 |
63 | Nephrolithiasis (HP:0000787) | 2.86812155 |
64 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.80755314 |
65 | Rickets (HP:0002748) | 2.80706286 |
66 | Malnutrition (HP:0004395) | 2.76733456 |
67 | Cardiovascular calcification (HP:0011915) | 2.75356073 |
68 | Hypophosphatemia (HP:0002148) | 2.68707532 |
69 | Lethargy (HP:0001254) | 2.68064001 |
70 | Focal segmental glomerulosclerosis (HP:0000097) | 2.61863154 |
71 | Vomiting (HP:0002013) | 2.59633932 |
72 | Abnormal enzyme/coenzyme activity (HP:0012379) | 2.57679682 |
73 | Abnormality of serum amino acid levels (HP:0003112) | 2.57258987 |
74 | Enlarged kidneys (HP:0000105) | 2.52155028 |
75 | Delayed epiphyseal ossification (HP:0002663) | 2.51935618 |
76 | Hypoglycemic coma (HP:0001325) | 2.49552413 |
77 | Confusion (HP:0001289) | 2.49371030 |
78 | Hypokalemia (HP:0002900) | 2.48601528 |
79 | Sensorimotor neuropathy (HP:0007141) | 2.48520591 |
80 | Hypotension (HP:0002615) | 2.47526898 |
81 | Fat malabsorption (HP:0002630) | 2.44573386 |
82 | Nephritis (HP:0000123) | 2.43894505 |
83 | Abnormality of alkaline phosphatase activity (HP:0004379) | 2.43851491 |
84 | Deep venous thrombosis (HP:0002625) | 2.43048496 |
85 | Chondrocalcinosis (HP:0000934) | 2.42980081 |
86 | Adrenal overactivity (HP:0002717) | 2.42912707 |
87 | Methylmalonic aciduria (HP:0012120) | 2.41255156 |
88 | Gingival bleeding (HP:0000225) | 2.39795381 |
89 | Abnormal platelet function (HP:0011869) | 2.37077411 |
90 | Impaired platelet aggregation (HP:0003540) | 2.37077411 |
91 | Menorrhagia (HP:0000132) | 2.36918879 |
92 | Nephrocalcinosis (HP:0000121) | 2.36455521 |
93 | Irritability (HP:0000737) | 2.35786316 |
94 | Abnormality of Sharpey fibers (HP:0100685) | 2.32062916 |
95 | Abnormality of sodium homeostasis (HP:0010931) | 2.31100123 |
96 | Vacuolated lymphocytes (HP:0001922) | 2.30339755 |
97 | Abnormal tarsal ossification (HP:0008369) | 2.29632960 |
98 | Widely patent fontanelles and sutures (HP:0004492) | 2.29169578 |
99 | Neonatal onset (HP:0003623) | 2.29128658 |
100 | Osteomalacia (HP:0002749) | 2.26843610 |
101 | Purpura (HP:0000979) | 2.23423989 |
102 | Hemorrhage of the eye (HP:0011885) | 2.19818780 |
103 | Late onset (HP:0003584) | 2.19810036 |
104 | Glomerulosclerosis (HP:0000096) | 2.18251667 |
105 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.17189785 |
106 | Abnormality of potassium homeostasis (HP:0011042) | 2.11858472 |
107 | Elevated alkaline phosphatase (HP:0003155) | 2.11018280 |
108 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.10978299 |
109 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.10272938 |
110 | Hypobetalipoproteinemia (HP:0003563) | 2.09791182 |
111 | Dehydration (HP:0001944) | 2.08914796 |
112 | Abnormality of vitamin metabolism (HP:0100508) | 2.08361052 |
113 | Hepatocellular carcinoma (HP:0001402) | 2.06511919 |
114 | Tubular atrophy (HP:0000092) | 2.05477520 |
115 | Nausea (HP:0002018) | 2.03136758 |
116 | Abnormality of the intrinsic pathway (HP:0010989) | 2.02501114 |
117 | Metaphyseal cupping (HP:0003021) | 2.01135951 |
118 | Spastic diplegia (HP:0001264) | 2.00773292 |
119 | Hypoalphalipoproteinemia (HP:0003233) | 2.00271778 |
120 | Abnormality of renal resorption (HP:0011038) | 1.97506386 |
121 | Cerebral edema (HP:0002181) | 1.96894456 |
122 | Hypercholesterolemia (HP:0003124) | 1.95402980 |
123 | Hyperbilirubinemia (HP:0002904) | 1.92830236 |
124 | Renal tubular dysfunction (HP:0000124) | 1.90391570 |
125 | Abnormality of methionine metabolism (HP:0010901) | 1.90160772 |
126 | Pancreatitis (HP:0001733) | 1.89652238 |
127 | Hypophosphatemic rickets (HP:0004912) | 1.89111270 |
128 | Hyperlipoproteinemia (HP:0010980) | 1.86891105 |
129 | Epidermoid cyst (HP:0200040) | 1.84112552 |
130 | Mitral stenosis (HP:0001718) | 1.84051220 |
131 | Complement deficiency (HP:0004431) | 1.83485003 |
132 | Protuberant abdomen (HP:0001538) | 1.79948321 |
133 | Hyponatremia (HP:0002902) | 1.77465856 |
134 | Thrombophlebitis (HP:0004418) | 1.77199253 |
135 | Conjugated hyperbilirubinemia (HP:0002908) | 1.77099182 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WNK4 | 8.07726189 |
2 | WNK3 | 5.85947801 |
3 | OXSR1 | 5.72968980 |
4 | BCKDK | 5.55029935 |
5 | STK39 | 3.55221502 |
6 | STK38L | 2.68010159 |
7 | FGFR4 | 2.14843400 |
8 | ERN1 | 2.10601534 |
9 | PDK4 | 2.09253841 |
10 | PDK3 | 2.09253841 |
11 | NEK1 | 1.99013556 |
12 | MST1R | 1.96110655 |
13 | SGK223 | 1.74731102 |
14 | SGK494 | 1.74731102 |
15 | GRK6 | 1.61092280 |
16 | WNK1 | 1.59055712 |
17 | SIK1 | 1.42703297 |
18 | STK38 | 1.38863768 |
19 | PDK2 | 1.35606354 |
20 | PINK1 | 1.30802038 |
21 | TRIB3 | 1.28420915 |
22 | ACVR1B | 1.16649422 |
23 | FGFR3 | 1.16068962 |
24 | ERBB4 | 1.11065300 |
25 | INSRR | 1.08571658 |
26 | MAPK11 | 1.02632821 |
27 | EPHB1 | 0.99644819 |
28 | STK24 | 0.99060309 |
29 | SGK3 | 0.97897679 |
30 | MST4 | 0.94023543 |
31 | LATS1 | 0.93014130 |
32 | MAP3K7 | 0.92043933 |
33 | SGK2 | 0.92037880 |
34 | PTK6 | 0.91089699 |
35 | FRK | 0.85656626 |
36 | ABL2 | 0.83268488 |
37 | GSK3A | 0.81731218 |
38 | IRAK3 | 0.80734961 |
39 | MET | 0.80665416 |
40 | LRRK2 | 0.77845277 |
41 | NTRK3 | 0.74170765 |
42 | PTK2 | 0.72585966 |
43 | EPHA4 | 0.71065950 |
44 | PRKAA2 | 0.70201237 |
45 | DYRK1B | 0.66649742 |
46 | MAP2K4 | 0.65454943 |
47 | MUSK | 0.64743112 |
48 | PRKAA1 | 0.63559758 |
49 | PDPK1 | 0.62682704 |
50 | PIK3CA | 0.59557239 |
51 | MAP3K3 | 0.58523196 |
52 | LMTK2 | 0.58284559 |
53 | PRKCZ | 0.57933995 |
54 | MAPKAPK3 | 0.55335810 |
55 | KSR2 | 0.54019361 |
56 | RIPK1 | 0.53850671 |
57 | PRKG2 | 0.50075820 |
58 | SGK1 | 0.48810688 |
59 | TIE1 | 0.48138887 |
60 | MAPK12 | 0.47493513 |
61 | STK3 | 0.46760086 |
62 | CSF1R | 0.45202305 |
63 | MAPK15 | 0.45008728 |
64 | GRK1 | 0.44695223 |
65 | NLK | 0.42282934 |
66 | EPHA3 | 0.41775113 |
67 | PRKACG | 0.40567483 |
68 | BMX | 0.40417323 |
69 | IRAK2 | 0.39455100 |
70 | PDK1 | 0.39153685 |
71 | PAK3 | 0.38670888 |
72 | TGFBR2 | 0.37549146 |
73 | JAK2 | 0.36601760 |
74 | ILK | 0.36397045 |
75 | NTRK1 | 0.35648431 |
76 | PIK3CG | 0.34443490 |
77 | MAP3K14 | 0.33932815 |
78 | CAMKK2 | 0.33855407 |
79 | YES1 | 0.32589177 |
80 | MAP3K2 | 0.30721642 |
81 | FER | 0.30578488 |
82 | MAP2K2 | 0.30222979 |
83 | RET | 0.30170715 |
84 | PKN2 | 0.30147167 |
85 | SIK3 | 0.29739844 |
86 | SRC | 0.29710298 |
87 | TAOK3 | 0.28947541 |
88 | PRKCI | 0.28947007 |
89 | MAP2K6 | 0.28793604 |
90 | PTK2B | 0.28224708 |
91 | IRAK1 | 0.27194327 |
92 | ZAP70 | 0.27073403 |
93 | CAMK2G | 0.26813757 |
94 | MAPK4 | 0.26648730 |
95 | MAP3K11 | 0.26057511 |
96 | MAP3K12 | 0.25964103 |
97 | ADRBK2 | 0.25875793 |
98 | TEC | 0.25743617 |
99 | NME2 | 0.25637245 |
100 | KIT | 0.25623254 |
101 | PRKCB | 0.25594689 |
102 | FGR | 0.25242673 |
103 | PRKCA | 0.25207257 |
104 | PRKG1 | 0.25062939 |
105 | PRKCD | 0.24983250 |
106 | BMPR2 | 0.23624919 |
107 | TRPM7 | 0.23571959 |
108 | TAOK1 | 0.23566256 |
109 | TYK2 | 0.23217366 |
110 | NEK9 | 0.22647681 |
111 | ERBB2 | 0.22169463 |
112 | CSNK1A1 | 0.21932608 |
113 | PRKCG | 0.21434712 |
114 | BTK | 0.21034913 |
115 | MAP2K3 | 0.20826926 |
116 | DAPK2 | 0.20639116 |
117 | AKT2 | 0.20380059 |
118 | PAK4 | 0.20341068 |
119 | STK11 | 0.20315902 |
120 | PRKCQ | 0.18310100 |
121 | PRPF4B | 0.17650139 |
122 | PRKCH | 0.17246918 |
123 | JAK1 | 0.16636860 |
124 | PRKACA | 0.16578098 |
125 | KDR | 0.16495153 |
126 | MYLK | 0.16202109 |
127 | PDGFRA | 0.15899665 |
128 | MAP2K1 | 0.14658771 |
129 | MAP3K1 | 0.14541293 |
130 | BLK | 0.14501938 |
131 | IGF1R | 0.14117247 |
132 | CSK | 0.13600006 |
133 | NME1 | 0.13566644 |
134 | FGFR2 | 0.13190946 |
135 | PHKG2 | 0.12929190 |
136 | PHKG1 | 0.12929190 |
137 | TBK1 | 0.11186505 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.60315215 |
2 | Butanoate metabolism_Homo sapiens_hsa00650 | 3.22432765 |
3 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.04139433 |
4 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 3.03065269 |
5 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.93138229 |
6 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.85035783 |
7 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.81248731 |
8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.77343409 |
9 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.66382236 |
10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.56886447 |
11 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.51008867 |
12 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.50171115 |
13 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.48733844 |
14 | Peroxisome_Homo sapiens_hsa04146 | 2.46541258 |
15 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.42446838 |
16 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.16846239 |
17 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.12018109 |
18 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.11159614 |
19 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.09031066 |
20 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.03349133 |
21 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.93810091 |
22 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.86420126 |
23 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.84576333 |
24 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.81989090 |
25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.78109091 |
26 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.74333447 |
27 | Bile secretion_Homo sapiens_hsa04976 | 1.62788589 |
28 | Histidine metabolism_Homo sapiens_hsa00340 | 1.58514902 |
29 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.55765681 |
30 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.55007202 |
31 | Carbon metabolism_Homo sapiens_hsa01200 | 1.52078907 |
32 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.48996439 |
33 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.45471427 |
34 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.39185226 |
35 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.38208934 |
36 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.35619101 |
37 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.33645848 |
38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.33521916 |
39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.33262010 |
40 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.30432717 |
41 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.24040863 |
42 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.23984258 |
43 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.21323047 |
44 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.20273104 |
45 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.15759550 |
46 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.05757871 |
47 | Retinol metabolism_Homo sapiens_hsa00830 | 1.05700454 |
48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.01402824 |
49 | Lysine degradation_Homo sapiens_hsa00310 | 1.01307536 |
50 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.00031842 |
51 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.98846444 |
52 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.98501324 |
53 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.89843217 |
54 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.88453722 |
55 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.87311844 |
56 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.84980511 |
57 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.83610892 |
58 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.80189388 |
59 | Mineral absorption_Homo sapiens_hsa04978 | 0.79452735 |
60 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.77736790 |
61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.77401210 |
62 | Prion diseases_Homo sapiens_hsa05020 | 0.74583523 |
63 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.72836348 |
64 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.69124791 |
65 | Sulfur relay system_Homo sapiens_hsa04122 | 0.67470008 |
66 | Other glycan degradation_Homo sapiens_hsa00511 | 0.62133321 |
67 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.62046022 |
68 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.61439211 |
69 | ABC transporters_Homo sapiens_hsa02010 | 0.59515888 |
70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.57330165 |
71 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.51862088 |
72 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.47549760 |
73 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.43189186 |
74 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.41609820 |
75 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.38913788 |
76 | Galactose metabolism_Homo sapiens_hsa00052 | 0.35085735 |
77 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.32648655 |
78 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.31038314 |
79 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.29647010 |
80 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.26795727 |
81 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.25673115 |
82 | Lysosome_Homo sapiens_hsa04142 | 0.25092325 |
83 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.23992441 |
84 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.23930179 |
85 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.22818807 |
86 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.22780835 |
87 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.19705673 |
88 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18158526 |
89 | Pertussis_Homo sapiens_hsa05133 | 0.16014838 |
90 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.12612730 |
91 | Insulin resistance_Homo sapiens_hsa04931 | 0.11139487 |
92 | Parkinsons disease_Homo sapiens_hsa05012 | 0.06947995 |
93 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.06770856 |
94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.05027021 |
95 | Hepatitis C_Homo sapiens_hsa05160 | -0.1432621 |
96 | Vibrio cholerae infection_Homo sapiens_hsa05110 | -0.1288079 |
97 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | -0.1144728 |
98 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.1085329 |
99 | Choline metabolism in cancer_Homo sapiens_hsa05231 | -0.1058595 |
100 | Alzheimers disease_Homo sapiens_hsa05010 | -0.0800288 |
101 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | -0.0642254 |
102 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | -0.0641367 |
103 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.0508580 |
104 | Platelet activation_Homo sapiens_hsa04611 | -0.0478925 |
105 | Pancreatic secretion_Homo sapiens_hsa04972 | -0.0466523 |
106 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | -0.0435602 |
107 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | -0.0420120 |
108 | Gastric acid secretion_Homo sapiens_hsa04971 | -0.0411518 |
109 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0400186 |
110 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0042565 |
111 | Glucagon signaling pathway_Homo sapiens_hsa04922 | -0.0030636 |