NAT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.91837892
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.91837892
3L-phenylalanine metabolic process (GO:0006558)5.74733726
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.74733726
5GDP-mannose metabolic process (GO:0019673)5.39487036
6ribosomal small subunit assembly (GO:0000028)5.18213092
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.89288168
8aromatic amino acid family catabolic process (GO:0009074)4.78732778
9ribosomal small subunit biogenesis (GO:0042274)4.78003570
10rRNA modification (GO:0000154)4.69058471
11pyrimidine nucleotide catabolic process (GO:0006244)4.56383680
12regulation of mitochondrial translation (GO:0070129)4.54371267
13peptidyl-histidine modification (GO:0018202)4.53308631
14viral transcription (GO:0019083)4.52875187
15ncRNA 3-end processing (GO:0043628)4.48055735
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.42012910
17translational termination (GO:0006415)4.24899676
18proline biosynthetic process (GO:0006561)4.24362933
19maturation of SSU-rRNA (GO:0030490)4.24125805
20response to misfolded protein (GO:0051788)4.21056199
21glucose 6-phosphate metabolic process (GO:0051156)4.16746589
22regulation of cholesterol esterification (GO:0010872)4.14886011
23bile acid biosynthetic process (GO:0006699)4.13676333
24rRNA methylation (GO:0031167)4.09476728
25mannose metabolic process (GO:0006013)4.09001486
26indole-containing compound catabolic process (GO:0042436)4.06586212
27indolalkylamine catabolic process (GO:0046218)4.06586212
28tryptophan catabolic process (GO:0006569)4.06586212
29aldehyde catabolic process (GO:0046185)4.03354952
30peptidyl-arginine omega-N-methylation (GO:0035247)3.99562365
31cofactor catabolic process (GO:0051187)3.94968146
32regulation of translational fidelity (GO:0006450)3.94434759
33high-density lipoprotein particle remodeling (GO:0034375)3.93381956
34cysteine metabolic process (GO:0006534)3.91054604
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90668989
36tryptophan metabolic process (GO:0006568)3.87512272
37glyoxylate metabolic process (GO:0046487)3.86040006
38tRNA modification (GO:0006400)3.84662894
39tRNA methylation (GO:0030488)3.84308471
40translational elongation (GO:0006414)3.83119522
41protein carboxylation (GO:0018214)3.82909149
42peptidyl-glutamic acid carboxylation (GO:0017187)3.82909149
43phospholipid efflux (GO:0033700)3.79669509
44protein insertion into membrane (GO:0051205)3.79653201
45viral mRNA export from host cell nucleus (GO:0046784)3.79502994
46formation of translation preinitiation complex (GO:0001731)3.79314805
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79288860
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.78175192
49mitochondrion transport along microtubule (GO:0047497)3.78175192
50kynurenine metabolic process (GO:0070189)3.71936444
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69926967
52urea metabolic process (GO:0019627)3.69544794
53urea cycle (GO:0000050)3.69544794
54sulfur amino acid catabolic process (GO:0000098)3.66834162
55establishment of mitochondrion localization (GO:0051654)3.66240380
56metallo-sulfur cluster assembly (GO:0031163)3.61544129
57iron-sulfur cluster assembly (GO:0016226)3.61544129
58aromatic amino acid family metabolic process (GO:0009072)3.60276026
59viral life cycle (GO:0019058)3.59958766
60cotranslational protein targeting to membrane (GO:0006613)3.58955801
61ribonucleoprotein complex biogenesis (GO:0022613)3.57232614
62protein targeting to ER (GO:0045047)3.55914559
63base-excision repair, AP site formation (GO:0006285)3.54669845
64coenzyme catabolic process (GO:0009109)3.52797523
65UV protection (GO:0009650)3.52174199
66ribosome biogenesis (GO:0042254)3.51395240
67nitrogen cycle metabolic process (GO:0071941)3.51005187
68regulation of triglyceride catabolic process (GO:0010896)3.48462754
69alpha-linolenic acid metabolic process (GO:0036109)3.45284359
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44096462
71adenine nucleotide transport (GO:0051503)3.42480363
72protein localization to endoplasmic reticulum (GO:0070972)3.42464854
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40155842
74translational initiation (GO:0006413)3.39000708
75protein maturation by protein folding (GO:0022417)3.38211868
76cellular component biogenesis (GO:0044085)3.34522087
77pentose metabolic process (GO:0019321)3.34226428
78bile acid metabolic process (GO:0008206)3.34182915
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33396822
80complement activation, alternative pathway (GO:0006957)3.32828981
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30081424
82purine ribonucleotide transport (GO:0015868)3.29754436
83low-density lipoprotein particle remodeling (GO:0034374)3.27947637
84cellular protein complex disassembly (GO:0043624)3.24215026
85protein-lipid complex remodeling (GO:0034368)3.24095291
86macromolecular complex remodeling (GO:0034367)3.24095291
87plasma lipoprotein particle remodeling (GO:0034369)3.24095291
88negative regulation of DNA-templated transcription, elongation (GO:0032785)3.24008465
89regulation of protein activation cascade (GO:2000257)3.23889637
90homocysteine metabolic process (GO:0050667)3.23486235
91inner mitochondrial membrane organization (GO:0007007)3.23389540
92reverse cholesterol transport (GO:0043691)3.22517132
93sulfur amino acid biosynthetic process (GO:0000097)3.20285884
94negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17990789
95regulation of cholesterol metabolic process (GO:0090181)3.17703781
96proline metabolic process (GO:0006560)3.16970020
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16617455
98tRNA aminoacylation for protein translation (GO:0006418)3.16218755
99amino-acid betaine metabolic process (GO:0006577)3.15618518
100protein complex disassembly (GO:0043241)3.14510144
101peptidyl-arginine methylation (GO:0018216)3.14003384
102peptidyl-arginine N-methylation (GO:0035246)3.14003384
103histone arginine methylation (GO:0034969)3.13825488
104fatty acid catabolic process (GO:0009062)3.12961714
105alpha-amino acid catabolic process (GO:1901606)3.12768552
106tRNA aminoacylation (GO:0043039)3.11772861
107amino acid activation (GO:0043038)3.11772861
108plasma lipoprotein particle clearance (GO:0034381)3.11358951
109tyrosine metabolic process (GO:0006570)3.10149558
110fatty acid oxidation (GO:0019395)3.10127938
111fatty acid beta-oxidation (GO:0006635)3.09597875
112peroxisome organization (GO:0007031)3.08031799
113lysine metabolic process (GO:0006553)3.07668225
114lysine catabolic process (GO:0006554)3.07668225
115protein targeting to mitochondrion (GO:0006626)3.07042191
116pseudouridine synthesis (GO:0001522)3.06824151
117protein complex biogenesis (GO:0070271)3.06796895
118regulation of complement activation (GO:0030449)3.06401785
119rRNA transcription (GO:0009303)3.06383910
120lipid oxidation (GO:0034440)3.04953654
121regulation of fibrinolysis (GO:0051917)3.02036670
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01915423
123tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01915423
124macromolecular complex disassembly (GO:0032984)3.01254644
125killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.00895302
126disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.00895302
127deoxyribonucleotide catabolic process (GO:0009264)3.00814917
128respiratory electron transport chain (GO:0022904)3.00677826
129protein retention in ER lumen (GO:0006621)3.00155553
130COPI coating of Golgi vesicle (GO:0048205)3.00148212
131Golgi transport vesicle coating (GO:0048200)3.00148212
132regulation of cholesterol biosynthetic process (GO:0045540)2.98699169
133indolalkylamine metabolic process (GO:0006586)2.98664487
134monocarboxylic acid catabolic process (GO:0072329)2.98144267
135negative regulation of fibrinolysis (GO:0051918)2.96978441
136negative regulation of sterol transport (GO:0032372)2.95530626
137negative regulation of cholesterol transport (GO:0032375)2.95530626
138electron transport chain (GO:0022900)2.95403291
139ribosomal large subunit biogenesis (GO:0042273)2.95386310
140RNA methylation (GO:0001510)2.94608973
141organic acid catabolic process (GO:0016054)2.93383367
142carboxylic acid catabolic process (GO:0046395)2.93383367
143tRNA metabolic process (GO:0006399)2.92882346
144establishment of protein localization to mitochondrion (GO:0072655)2.92654793
145cellular amino acid catabolic process (GO:0009063)2.92355311
146ubiquinone biosynthetic process (GO:0006744)2.91925615
147cellular biogenic amine catabolic process (GO:0042402)2.91894674
148amine catabolic process (GO:0009310)2.91894674
149translation (GO:0006412)2.91587313
150misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.91203327
151short-chain fatty acid metabolic process (GO:0046459)2.91055687
152bile acid and bile salt transport (GO:0015721)2.89943553
153cytochrome complex assembly (GO:0017004)2.89846804
154mitochondrial respiratory chain complex assembly (GO:0033108)2.89502822
155cellular ketone body metabolic process (GO:0046950)2.89075516
156aspartate family amino acid catabolic process (GO:0009068)2.88348617
157sulfur amino acid metabolic process (GO:0000096)2.87668777
158deoxyribose phosphate catabolic process (GO:0046386)2.86558089
159fibrinolysis (GO:0042730)2.86498329
160poly(A)+ mRNA export from nucleus (GO:0016973)2.86352790
161serine family amino acid catabolic process (GO:0009071)2.86158377
162purine nucleotide transport (GO:0015865)2.85453011
163flavonoid metabolic process (GO:0009812)2.82864142
164regulation of translation in response to stress (GO:0043555)2.82475541
165fat-soluble vitamin biosynthetic process (GO:0042362)2.81781592
166tRNA processing (GO:0008033)2.81053572
167methionine metabolic process (GO:0006555)2.79940254
168chaperone-mediated protein transport (GO:0072321)2.79898912
169triglyceride homeostasis (GO:0070328)2.79844690
170acylglycerol homeostasis (GO:0055090)2.79844690
171L-methionine salvage (GO:0071267)2.79469388
172L-methionine biosynthetic process (GO:0071265)2.79469388
173amino acid salvage (GO:0043102)2.79469388
174DNA strand renaturation (GO:0000733)2.78756475
175cholesterol efflux (GO:0033344)2.78568667
176peroxisome fission (GO:0016559)2.78386262
177very long-chain fatty acid metabolic process (GO:0000038)2.78384112
178dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76551300
179blood coagulation, intrinsic pathway (GO:0007597)2.76082873
180nuclear-transcribed mRNA catabolic process (GO:0000956)2.75767022
181methionine biosynthetic process (GO:0009086)2.75486302
182benzene-containing compound metabolic process (GO:0042537)2.74870704
183imidazole-containing compound metabolic process (GO:0052803)2.74558743
184negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74150882
185glutathione metabolic process (GO:0006749)2.73751538
186heme transport (GO:0015886)2.73736990
187fructose metabolic process (GO:0006000)2.73455919
188fatty acid elongation (GO:0030497)2.73242972
189maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73174357
190positive regulation of triglyceride lipase activity (GO:0061365)2.73047794
191positive regulation of lipoprotein lipase activity (GO:0051006)2.73047794
192rRNA processing (GO:0006364)2.71962316
193regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69425814
194nuclear envelope reassembly (GO:0031468)2.69354563
195mitotic nuclear envelope reassembly (GO:0007084)2.69354563
196mitochondrial respiratory chain complex I assembly (GO:0032981)2.67588753
197NADH dehydrogenase complex assembly (GO:0010257)2.67588753
198mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67588753
199regulation of double-strand break repair via homologous recombination (GO:0010569)2.67250330
200nucleotide-excision repair, DNA damage removal (GO:0000718)2.66507420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.18569732
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.84508465
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.62809474
4CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.46867330
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.24463860
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94334008
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.72816527
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.61230597
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.52847650
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.32146679
11GATA1_22025678_ChIP-Seq_K562_Human3.31006810
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94753633
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.65125365
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64292967
15XRN2_22483619_ChIP-Seq_HELA_Human2.52688609
16VDR_21846776_ChIP-Seq_THP-1_Human2.37993713
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30806693
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30449834
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.27883244
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24126150
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.12554573
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09969624
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.09787432
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06958406
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03816245
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03353140
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98894871
28LXR_22292898_ChIP-Seq_THP-1_Human1.97625713
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.95947044
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87387288
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.86312722
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83953404
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.81384254
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81106469
35MYC_22102868_ChIP-Seq_BL_Human1.79225359
36P68_20966046_ChIP-Seq_HELA_Human1.73898088
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69915727
38CIITA_25753668_ChIP-Seq_RAJI_Human1.68573063
39E2F7_22180533_ChIP-Seq_HELA_Human1.59808262
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58428965
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57627328
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55844816
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55339959
44TTF2_22483619_ChIP-Seq_HELA_Human1.54043331
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.53706048
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51937324
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51530430
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50997418
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50311544
50FOXP1_21924763_ChIP-Seq_HESCs_Human1.50168877
51KDM5A_27292631_Chip-Seq_BREAST_Human1.50078997
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49787348
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.49616649
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48971856
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48657680
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.47696174
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47020571
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43921765
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42752705
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39763424
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39609861
62FOXP3_21729870_ChIP-Seq_TREG_Human1.38636678
63BCL6_27268052_Chip-Seq_Bcells_Human1.37106743
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36596056
65RACK7_27058665_Chip-Seq_MCF-7_Human1.36023174
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34752168
67* MAF_26560356_Chip-Seq_TH2_Human1.34708731
68RARB_24833708_ChIP-Seq_LIVER_Mouse1.34530090
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33469543
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31809751
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.30389348
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29722561
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29544045
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28782885
75PHF8_20622854_ChIP-Seq_HELA_Human1.28150049
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.26839478
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25273051
78* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24617465
79BCOR_27268052_Chip-Seq_Bcells_Human1.23678540
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23053587
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21960758
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21800793
83E2F1_20622854_ChIP-Seq_HELA_Human1.20740345
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20299829
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18961522
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18405254
87NCOR1_26117541_ChIP-Seq_K562_Human1.17948195
88RARA_24833708_ChIP-Seq_LIVER_Mouse1.15820340
89SMC4_20622854_ChIP-Seq_HELA_Human1.15488417
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15442369
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14883819
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13680694
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13008371
94TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12757999
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12275342
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10609712
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.10338986
98TP53_22127205_ChIP-Seq_IMR90_Human1.09872369
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09823902
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09772193
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09045101
102HTT_18923047_ChIP-ChIP_STHdh_Human1.08495151
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08146752
104CTCF_21964334_Chip-Seq_Bcells_Human1.08142409
105ZNF263_19887448_ChIP-Seq_K562_Human1.05959044
106KDM2B_26808549_Chip-Seq_DND41_Human1.05593121
107VDR_23849224_ChIP-Seq_CD4+_Human1.05587537
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05193252
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04785283
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04614237
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.04324336
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.03888160
113TFEB_21752829_ChIP-Seq_HELA_Human1.03792667
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03318459
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02772559
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02641296
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02511830
118STAT1_20625510_ChIP-Seq_HELA_Human1.00916288
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99625493
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96986048
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95452729
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94682706
123CTCF_20526341_ChIP-Seq_ESCs_Human0.94479639
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93916603
125GATA3_21867929_ChIP-Seq_CD8_Mouse0.93904619
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93782738
127IRF1_19129219_ChIP-ChIP_H3396_Human0.93195881
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91630038
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90944350
130* GABP_19822575_ChIP-Seq_HepG2_Human0.90063728
131* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88766164
132RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88611534
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.88493907
134AR_20517297_ChIP-Seq_VCAP_Human0.88456818
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87215805
136DCP1A_22483619_ChIP-Seq_HELA_Human0.86685248
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86580105
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86579752
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86406562
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.86390866
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86153746
142CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85846984
143SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85666540
144SOX2_22085726_ChIP-Seq_NPCs_Mouse0.83426637
145* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83150922
146PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82884406
147NANOG_20526341_ChIP-Seq_ESCs_Human0.80912360
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.80878024
149MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80511669
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.80311298
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80273096
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80264130
153CTCF_26484167_Chip-Seq_Bcells_Mouse0.78159919
154ERG_20517297_ChIP-Seq_VCAP_Human0.76598899
155P53_21459846_ChIP-Seq_SAOS-2_Human0.76507295
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75698450
157* TAF2_19829295_ChIP-Seq_ESCs_Human0.75058272
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74443068
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74244385
160NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73066112
161GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72895250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.70379677
2MP0005360_urolithiasis4.83988640
3MP0005365_abnormal_bile_salt4.72321378
4MP0008875_abnormal_xenobiotic_pharmacok4.47090465
5MP0005085_abnormal_gallbladder_physiolo4.39910009
6MP0005058_abnormal_lysosome_morphology4.21791116
7MP0003806_abnormal_nucleotide_metabolis4.17252542
8MP0009840_abnormal_foam_cell3.37271540
9MP0006292_abnormal_olfactory_placode3.20439615
10MP0001348_abnormal_lacrimal_gland3.19333618
11MP0008260_abnormal_autophagy3.05194726
12MP0008995_early_reproductive_senescence2.86573604
13MP0003693_abnormal_embryo_hatching2.83768019
14MP0010329_abnormal_lipoprotein_level2.76407927
15MP0008789_abnormal_olfactory_epithelium2.70200160
16MP0009379_abnormal_foot_pigmentation2.68280409
17MP0003191_abnormal_cellular_cholesterol2.65224834
18MP0003786_premature_aging2.63153366
19MP0003111_abnormal_nucleus_morphology2.55801518
20MP0005083_abnormal_biliary_tract2.55759573
21MP0008058_abnormal_DNA_repair2.45063113
22MP0010030_abnormal_orbit_morphology2.44632455
23MP0005332_abnormal_amino_acid2.41394793
24MP0003186_abnormal_redox_activity2.39828122
25MP0002653_abnormal_ependyma_morphology2.38496045
26MP0005394_taste/olfaction_phenotype2.37865952
27MP0005499_abnormal_olfactory_system2.37865952
28MP0003195_calcinosis2.27856249
29MP0009384_cardiac_valve_regurgitation2.21727113
30MP0003252_abnormal_bile_duct2.19680342
31MP0001666_abnormal_nutrient_absorption2.12887254
32MP0002837_dystrophic_cardiac_calcinosis1.94660745
33MP0004019_abnormal_vitamin_homeostasis1.92387360
34MP0006036_abnormal_mitochondrial_physio1.86256508
35MP0002876_abnormal_thyroid_physiology1.84431198
36MP0002118_abnormal_lipid_homeostasis1.81345298
37MP0005451_abnormal_body_composition1.80937914
38MP0001764_abnormal_homeostasis1.77633100
39MP0008007_abnormal_cellular_replicative1.72015536
40MP0004510_myositis1.70823233
41MP0001849_ear_inflammation1.70183456
42MP0005670_abnormal_white_adipose1.70173484
43MP0005319_abnormal_enzyme/_coenzyme1.65863029
44MP0000609_abnormal_liver_physiology1.62654564
45MP0002138_abnormal_hepatobiliary_system1.60619228
46MP0009697_abnormal_copulation1.60131587
47MP0003077_abnormal_cell_cycle1.58983596
48MP0003136_yellow_coat_color1.56704908
49MP0005410_abnormal_fertilization1.55088072
50MP0005584_abnormal_enzyme/coenzyme_acti1.53613852
51MP0004147_increased_porphyrin_level1.53058179
52MP0005174_abnormal_tail_pigmentation1.49829082
53MP0009643_abnormal_urine_homeostasis1.49536778
54MP0005171_absent_coat_pigmentation1.44590031
55MP0008932_abnormal_embryonic_tissue1.44557259
56MP0000003_abnormal_adipose_tissue1.44407088
57MP0003011_delayed_dark_adaptation1.40435997
58MP0003656_abnormal_erythrocyte_physiolo1.40025819
59MP0010094_abnormal_chromosome_stability1.39699315
60MP0004133_heterotaxia1.39167477
61MP0005636_abnormal_mineral_homeostasis1.37214449
62MP0005257_abnormal_intraocular_pressure1.36489224
63MP0004957_abnormal_blastocyst_morpholog1.35790875
64MP0002160_abnormal_reproductive_system1.26324085
65MP0005084_abnormal_gallbladder_morpholo1.26151956
66MP0008469_abnormal_protein_level1.24106087
67MP0001299_abnormal_eye_distance/1.23320986
68MP0003724_increased_susceptibility_to1.22782814
69MP0000604_amyloidosis1.22462622
70MP0001984_abnormal_olfaction1.20812393
71MP0005501_abnormal_skin_physiology1.19079731
72MP0009278_abnormal_bone_marrow1.17167502
73MP0000313_abnormal_cell_death1.15644214
74MP0000750_abnormal_muscle_regeneration1.13297798
75MP0001502_abnormal_circadian_rhythm1.12636476
76MP0002938_white_spotting1.12325592
77MP0000537_abnormal_urethra_morphology1.09735953
78MP0002132_abnormal_respiratory_system1.05540882
79MP0000015_abnormal_ear_pigmentation1.04573580
80MP0003123_paternal_imprinting1.03326357
81MP0001756_abnormal_urination1.02954376
82MP0001986_abnormal_taste_sensitivity1.02945064
83MP0003942_abnormal_urinary_system1.00963899
84MP0003122_maternal_imprinting1.00669075
85MP0005408_hypopigmentation1.00065639
86MP0010368_abnormal_lymphatic_system0.99659037
87MP0001529_abnormal_vocalization0.99302129
88MP0009764_decreased_sensitivity_to0.98570293
89MP0001835_abnormal_antigen_presentation0.98405980
90MP0002080_prenatal_lethality0.98380103
91MP0001697_abnormal_embryo_size0.98237402
92MP0002249_abnormal_larynx_morphology0.98064367
93MP0002148_abnormal_hypersensitivity_rea0.96838880
94MP0006035_abnormal_mitochondrial_morpho0.96581764
95MP0000598_abnormal_liver_morphology0.96031220
96MP0005464_abnormal_platelet_physiology0.92984684
97MP0009785_altered_susceptibility_to0.92097760
98MP0002075_abnormal_coat/hair_pigmentati0.92056534
99MP0005376_homeostasis/metabolism_phenot0.91709112
100MP0009642_abnormal_blood_homeostasis0.91645832
101MP0002019_abnormal_tumor_incidence0.91440781
102MP0001853_heart_inflammation0.90431905
103MP0002092_abnormal_eye_morphology0.89958736
104MP0006276_abnormal_autonomic_nervous0.88949707
105MP0000681_abnormal_thyroid_gland0.87317318
106MP0000749_muscle_degeneration0.86830275
107MP0000538_abnormal_urinary_bladder0.86688689
108MP0002210_abnormal_sex_determination0.86421149
109MP0005075_abnormal_melanosome_morpholog0.86050217
110MP0005266_abnormal_metabolism0.85245734
111MP0001730_embryonic_growth_arrest0.85122741
112MP0005423_abnormal_somatic_nervous0.84074027
113MP0000049_abnormal_middle_ear0.82910883
114MP0001270_distended_abdomen0.81475977
115MP0004782_abnormal_surfactant_physiolog0.80941557
116MP0002419_abnormal_innate_immunity0.79413285
117MP0003638_abnormal_response/metabolism_0.79237932
118MP0003315_abnormal_perineum_morphology0.77493913
119MP0004858_abnormal_nervous_system0.77390896
120MP0000230_abnormal_systemic_arterial0.76841777
121MP0002751_abnormal_autonomic_nervous0.76816267
122MP0003878_abnormal_ear_physiology0.76502192
123MP0005377_hearing/vestibular/ear_phenot0.76502192
124MP0009763_increased_sensitivity_to0.76176158
125MP0001145_abnormal_male_reproductive0.75931096
126MP0005397_hematopoietic_system_phenotyp0.75456431
127MP0001545_abnormal_hematopoietic_system0.75456431
128MP0001873_stomach_inflammation0.75173132
129MP0002254_reproductive_system_inflammat0.74838776
130MP0003329_amyloid_beta_deposits0.74293771
131MP0002078_abnormal_glucose_homeostasis0.73710776
132MP0000751_myopathy0.73638199
133MP0005025_abnormal_response_to0.73577911
134MP0001905_abnormal_dopamine_level0.73431397
135MP0008873_increased_physiological_sensi0.73103798
136MP0005379_endocrine/exocrine_gland_phen0.72317118
137MP0003172_abnormal_lysosome_physiology0.72194729
138MP0003436_decreased_susceptibility_to0.71671401
139MP0001672_abnormal_embryogenesis/_devel0.70919350
140MP0005380_embryogenesis_phenotype0.70919350
141MP0001845_abnormal_inflammatory_respons0.70817812
142MP0001186_pigmentation_phenotype0.70745156
143MP0003868_abnormal_feces_composition0.70144304
144MP0005535_abnormal_body_temperature0.69855063
145MP0005384_cellular_phenotype0.68571278
146MP0003984_embryonic_growth_retardation0.68375797
147MP0002085_abnormal_embryonic_tissue0.68229432
148MP0005165_increased_susceptibility_to0.66689486
149MP0003279_aneurysm0.65973620
150MP0000013_abnormal_adipose_tissue0.65901137
151MP0000350_abnormal_cell_proliferation0.65827009
152MP0001765_abnormal_ion_homeostasis0.65723683
153MP0003690_abnormal_glial_cell0.65347030
154MP0005334_abnormal_fat_pad0.65299204
155MP0004197_abnormal_fetal_growth/weight/0.64392371
156MP0002736_abnormal_nociception_after0.64112518
157MP0001293_anophthalmia0.62771084
158MP0009765_abnormal_xenobiotic_induced0.61137509
159MP0001661_extended_life_span0.61120334
160MP0000678_abnormal_parathyroid_gland0.61070375
161MP0003718_maternal_effect0.59813035
162MP0005647_abnormal_sex_gland0.59696986
163MP0002090_abnormal_vision0.59218911
164MP0000685_abnormal_immune_system0.58991068
165MP0004381_abnormal_hair_follicle0.58772814
166MP0000358_abnormal_cell_content/0.58379207
167MP0002295_abnormal_pulmonary_circulatio0.58239263
168MP0008872_abnormal_physiological_respon0.57858674
169MP0005671_abnormal_response_to0.57368351
170MP0002136_abnormal_kidney_physiology0.56607360
171MP0002971_abnormal_brown_adipose0.56217619
172MP0003879_abnormal_hair_cell0.55212558
173MP0004036_abnormal_muscle_relaxation0.54781165
174MP0003075_altered_response_to0.54572724
175MP0001663_abnormal_digestive_system0.52680423

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.35646338
2Microvesicular hepatic steatosis (HP:0001414)5.30190583
3Abnormality of methionine metabolism (HP:0010901)4.17682850
4Intrahepatic cholestasis (HP:0001406)4.08559268
5Xanthomatosis (HP:0000991)4.05510813
6Testicular atrophy (HP:0000029)3.98972528
7Prolonged partial thromboplastin time (HP:0003645)3.89929396
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.86961805
9Abnormality of aspartate family amino acid metabolism (HP:0010899)3.84499992
10Ragged-red muscle fibers (HP:0003200)3.76194309
11Poikiloderma (HP:0001029)3.66331323
12Hepatic necrosis (HP:0002605)3.64047360
13Hyperlipoproteinemia (HP:0010980)3.57539563
14Generalized aminoaciduria (HP:0002909)3.55037345
15Deep venous thrombosis (HP:0002625)3.51028123
16Abnormal number of erythroid precursors (HP:0012131)3.45380686
17Hypobetalipoproteinemia (HP:0003563)3.44550989
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44075323
19Abnormality of cells of the erythroid lineage (HP:0012130)3.43085227
20Abnormality of fatty-acid metabolism (HP:0004359)3.39110240
21Hepatocellular necrosis (HP:0001404)3.35754031
22Reticulocytopenia (HP:0001896)3.34490168
23Acute encephalopathy (HP:0006846)3.24273121
24Complement deficiency (HP:0004431)3.24130079
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.22463901
26Oligomenorrhea (HP:0000876)3.20114864
27Type I transferrin isoform profile (HP:0003642)3.17406708
28Cerebral edema (HP:0002181)3.11103477
29Acute necrotizing encephalopathy (HP:0006965)3.08920356
30Hyperglycinemia (HP:0002154)3.07358668
31Hyperammonemia (HP:0001987)3.06398766
32Mitochondrial inheritance (HP:0001427)3.05056416
33Progressive muscle weakness (HP:0003323)3.03041704
34Truncus arteriosus (HP:0001660)3.02372333
35Abnormality of DNA repair (HP:0003254)2.99910532
36Hypoglycemic coma (HP:0001325)2.98155468
37Rib fusion (HP:0000902)2.97864956
38Dicarboxylic aciduria (HP:0003215)2.96885660
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96885660
40Systemic lupus erythematosus (HP:0002725)2.94203353
41Abnormal mitochondria in muscle tissue (HP:0008316)2.93351721
42Increased CSF lactate (HP:0002490)2.92853544
43Abnormal protein glycosylation (HP:0012346)2.91758725
44Abnormal glycosylation (HP:0012345)2.91758725
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91758725
46Abnormal protein N-linked glycosylation (HP:0012347)2.91758725
47Entropion (HP:0000621)2.90635330
48Dysostosis multiplex (HP:0000943)2.89036060
49Lethargy (HP:0001254)2.80930978
50Ketosis (HP:0001946)2.78493381
51Brushfield spots (HP:0001088)2.77860147
52Muscle fiber atrophy (HP:0100295)2.73848692
53Hyperthyroidism (HP:0000836)2.72505610
54Microretrognathia (HP:0000308)2.71393222
55Vacuolated lymphocytes (HP:0001922)2.69748810
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69707791
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69707791
58Abnormality of serum amino acid levels (HP:0003112)2.68049622
59Cervical subluxation (HP:0003308)2.68011014
60Hypertensive crisis (HP:0100735)2.67394707
61Joint hemorrhage (HP:0005261)2.66464516
62Severe visual impairment (HP:0001141)2.65621108
63Squamous cell carcinoma (HP:0002860)2.64907090
64Abnormality of serine family amino acid metabolism (HP:0010894)2.62550514
65Abnormality of glycine metabolism (HP:0010895)2.62550514
66Hypolipoproteinemia (HP:0010981)2.60296164
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.56047451
68Hyperglycinuria (HP:0003108)2.55902111
69Abnormality of the intrinsic pathway (HP:0010989)2.53772022
70Neurofibrillary tangles (HP:0002185)2.50822423
71Lactic acidosis (HP:0003128)2.50515265
72Increased muscle lipid content (HP:0009058)2.49875354
73Abnormality of the common coagulation pathway (HP:0010990)2.48508484
74Type 2 muscle fiber atrophy (HP:0003554)2.47357507
75Broad distal phalanx of finger (HP:0009836)2.47258605
76Conjugated hyperbilirubinemia (HP:0002908)2.45183590
77Lipid accumulation in hepatocytes (HP:0006561)2.44170890
78Hyperbilirubinemia (HP:0002904)2.42182869
79Fat malabsorption (HP:0002630)2.41973463
80Glycosuria (HP:0003076)2.38663577
81Abnormality of urine glucose concentration (HP:0011016)2.38663577
82Renal Fanconi syndrome (HP:0001994)2.35948556
83Reduced antithrombin III activity (HP:0001976)2.35496412
84Progressive macrocephaly (HP:0004481)2.34157033
85Abnormality of complement system (HP:0005339)2.33120422
86Gout (HP:0001997)2.32570936
87Absent thumb (HP:0009777)2.32415072
88Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32289006
89Hyperacusis (HP:0010780)2.31077825
90Hypoplastic pelvis (HP:0008839)2.30756601
91Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28922541
92Increased intramyocellular lipid droplets (HP:0012240)2.28850559
93Ulnar bowing (HP:0003031)2.28750143
94Hypoalphalipoproteinemia (HP:0003233)2.27662483
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27519989
96Metabolic acidosis (HP:0001942)2.27216176
97Secondary amenorrhea (HP:0000869)2.25367937
98Abnormality of reticulocytes (HP:0004312)2.20723167
99Megaloblastic anemia (HP:0001889)2.20125531
100Exercise intolerance (HP:0003546)2.19817491
101Late onset (HP:0003584)2.18620933
102Hypercholesterolemia (HP:0003124)2.17541756
103Premature ovarian failure (HP:0008209)2.16156075
104Abnormality of pyrimidine metabolism (HP:0004353)2.15706585
105Seborrheic dermatitis (HP:0001051)2.15011069
106Stridor (HP:0010307)2.14677323
107Increased hepatocellular lipid droplets (HP:0006565)2.14442228
108Cerebral hypomyelination (HP:0006808)2.14371585
109Flat capital femoral epiphysis (HP:0003370)2.13322302
110J-shaped sella turcica (HP:0002680)2.13058598
111Biconcave vertebral bodies (HP:0004586)2.12612097
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12433369
113Absent epiphyses (HP:0010577)2.12433369
114Facial hemangioma (HP:0000329)2.11915888
115Vomiting (HP:0002013)2.11202662
116Joint stiffness (HP:0001387)2.10906553
117Methylmalonic aciduria (HP:0012120)2.10875093
118Abnormality of nucleobase metabolism (HP:0010932)2.10743497
119Cortical visual impairment (HP:0100704)2.10134811
120Abnormality of purine metabolism (HP:0004352)2.08261953
121Respiratory failure (HP:0002878)2.08185354
122Thin bony cortex (HP:0002753)2.07168726
123Hand muscle atrophy (HP:0009130)2.04476026
124Progressive microcephaly (HP:0000253)2.03025293
125Steatorrhea (HP:0002570)2.02052088
126Rough bone trabeculation (HP:0100670)2.01136931
127CNS demyelination (HP:0007305)2.00689048
128Increased serum lactate (HP:0002151)2.00198609
129Myopathic facies (HP:0002058)2.00150684
130Bile duct proliferation (HP:0001408)1.99052018
131Abnormal biliary tract physiology (HP:0012439)1.99052018
132Upper limb amyotrophy (HP:0009129)1.98933485
133Distal upper limb amyotrophy (HP:0007149)1.98933485
134Poor suck (HP:0002033)1.98271894
135Petechiae (HP:0000967)1.98177733
136Abnormal gallbladder physiology (HP:0012438)1.97870210
137Cholecystitis (HP:0001082)1.97870210
138Progressive external ophthalmoplegia (HP:0000590)1.97470332
139Recurrent gram-negative bacterial infections (HP:0005420)1.97008828
140Spastic paraparesis (HP:0002313)1.96781587
141Abnormality of vitamin metabolism (HP:0100508)1.95811804
142Abnormality of homocysteine metabolism (HP:0010919)1.94334551
143Homocystinuria (HP:0002156)1.94334551
144Atelectasis (HP:0100750)1.94031111
145Nausea (HP:0002018)1.93209836
146Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93165601
147Optic nerve coloboma (HP:0000588)1.91366140
148Abnormality of the vitamin B12 metabolism (HP:0004341)1.89162787
149Abnormality of vitamin B metabolism (HP:0004340)1.88428935
150Opisthotonus (HP:0002179)1.88108733
151Hypoplasia of the thymus (HP:0000778)1.88099127
152Proximal tubulopathy (HP:0000114)1.87010288
153Malnutrition (HP:0004395)1.85985827
154Abnormal gallbladder morphology (HP:0012437)1.85957486
155Delayed epiphyseal ossification (HP:0002663)1.85640182
156Epiphyseal stippling (HP:0010655)1.85370278
157Ketoacidosis (HP:0001993)1.84892508
158Emotional lability (HP:0000712)1.84711363
1593-Methylglutaconic aciduria (HP:0003535)1.84113320
160Short thumb (HP:0009778)1.83976844
161Cholelithiasis (HP:0001081)1.83041773
162Prolonged neonatal jaundice (HP:0006579)1.82718023
163Abnormality of iron homeostasis (HP:0011031)1.82589572
164Aplasia of the musculature (HP:0100854)1.82445693
165Cerebral palsy (HP:0100021)1.82418524
166Pointed chin (HP:0000307)1.82019234
167Glomerulonephritis (HP:0000099)1.80678716
168Hepatosplenomegaly (HP:0001433)1.80515953
169High anterior hairline (HP:0009890)1.78226293
170Short 5th finger (HP:0009237)1.76913253
171Abnormal trabecular bone morphology (HP:0100671)1.75630304
172Abnormal epiphyseal ossification (HP:0010656)1.69740477
173Pallor (HP:0000980)1.69148714
174Hypoplasia of the pons (HP:0012110)1.68451169
175Annular pancreas (HP:0001734)1.67809390
176Reticulocytosis (HP:0001923)1.66833535
177Breast hypoplasia (HP:0003187)1.63681365
178Failure to thrive in infancy (HP:0001531)1.62891876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.19261269
2MET3.42086665
3BMPR1B3.30458256
4NME23.21428371
5MST1R2.86129613
6PIM22.67518252
7TRIB32.64799167
8SIK12.57497303
9ICK2.46601598
10TESK22.37772536
11TAOK32.37349860
12VRK22.32954258
13MAP3K122.27871322
14GRK52.24527584
15BUB12.05600491
16ARAF2.03894344
17STK162.01919297
18SMG11.91060803
19CSF1R1.88524321
20MYLK1.85986177
21GRK71.85691492
22PDK31.82126509
23PDK41.82126509
24PTK2B1.68455149
25TGFBR21.65665406
26SRPK11.63702184
27TBK11.57628889
28SIK31.54655256
29MAP3K141.52008157
30MAPK151.51588169
31PIK3CA1.46334664
32AURKA1.46170035
33PIK3CG1.43798488
34EPHA21.40064566
35MAP2K71.37241383
36MST41.36573596
37ERN11.35721484
38PRKD21.35070032
39TAOK21.33941304
40MAP4K21.31986986
41MAP3K21.27209207
42LRRK21.27112086
43PDK21.26419525
44BRSK21.24877718
45CAMKK21.21423808
46ABL21.20993235
47SIK21.17752280
48MAP2K21.17662941
49MAPKAPK31.14729294
50EIF2AK11.14521263
51TSSK61.13893828
52NEK21.13185086
53TIE11.11585111
54PRKCI1.11382489
55MAP3K31.10880144
56FGR1.08837757
57PRPF4B1.07422409
58EPHB11.07246176
59MAPKAPK51.07083083
60MARK21.06501331
61BRAF1.02569400
62ATR1.01004558
63WEE11.00775022
64PINK10.97993826
65AKT30.93680665
66MAP2K30.92133683
67TYRO30.91712958
68KIT0.91310876
69TYK20.89555778
70STK390.88680908
71ZAK0.88488223
72CHEK20.84881154
73DAPK10.84526838
74FLT30.83802775
75NME10.82495148
76BMPR20.81683790
77TEC0.80893760
78PRKD30.80590335
79MAP3K60.80143164
80RPS6KA40.79358867
81CDC70.76958902
82DAPK30.76792217
83MAPK40.76487000
84KDR0.76308417
85MTOR0.75665497
86CDK70.75619541
87OXSR10.73716335
88WNK40.71784167
89IRAK30.71391674
90EPHB20.70688391
91DYRK20.69831351
92CASK0.69618396
93ILK0.69174290
94MOS0.69077496
95BTK0.68603759
96BMX0.68581830
97MAP3K110.67749645
98CSNK1G30.67531952
99TNK20.66497030
100PLK40.66008207
101TESK10.65399215
102CCNB10.64424536
103IKBKB0.64354373
104ERBB40.63902061
105FGFR40.63673541
106EIF2AK30.63096803
107CDK11A0.62732016
108IKBKE0.62164440
109PKN20.61800835
110GRK60.61260070
111PLK10.60776918
112AKT20.60637647
113FRK0.59888887
114RPS6KL10.59298593
115RPS6KC10.59298593
116LMTK20.58439923
117PBK0.58091373
118TRPM70.57826724
119IRAK40.57052442
120MUSK0.56682718
121BRSK10.56361028
122CDK190.54880641
123PRKG20.54594148
124RPS6KB20.53594264
125AURKB0.53026040
126RPS6KA20.52347367
127CAMK2G0.52010690
128BLK0.51775873
129CDK20.51488832
130SYK0.51457237
131CDK140.50631407
132PTK20.50326005
133CDK150.50272007
134CHEK10.49854101
135JAK30.48968029
136MAP2K60.48529236
137INSRR0.48369670
138MAPK120.47441665
139PRKAA10.47190716
140MAP2K10.46034665
141CDK180.45707840
142VRK10.45302494
143CSNK2A20.45067798
144PRKD10.44430614
145ZAP700.44085115
146CSNK1A1L0.42856589
147MAP4K10.42721042
148PAK40.41919279
149CAMK2D0.41106851
150RAF10.40867446
151PNCK0.40794161
152MAP3K80.40492937
153CDK40.40348181
154ADRBK20.40329387
155CDK10.39783084
156DYRK1B0.39550980
157MAP2K40.38117271
158MAPK110.37966401
159EEF2K0.36439688
160NTRK10.36134638
161ACVR1B0.35631121
162ADRBK10.35483780
163PAK10.34711082

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.24615903
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.17909768
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.04004709
4Base excision repair_Homo sapiens_hsa034102.95246364
5DNA replication_Homo sapiens_hsa030302.72848489
6Homologous recombination_Homo sapiens_hsa034402.50672109
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38932867
8Oxidative phosphorylation_Homo sapiens_hsa001902.29215255
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27091382
10Spliceosome_Homo sapiens_hsa030402.23827041
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18841187
12Sulfur metabolism_Homo sapiens_hsa009202.13385288
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10494712
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.05990429
15Selenocompound metabolism_Homo sapiens_hsa004502.04314605
16Fanconi anemia pathway_Homo sapiens_hsa034602.03453628
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03446586
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02721430
19Fatty acid elongation_Homo sapiens_hsa000622.00578230
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97632086
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97415497
22Peroxisome_Homo sapiens_hsa041461.95779561
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93362457
24Propanoate metabolism_Homo sapiens_hsa006401.91867520
25Fatty acid degradation_Homo sapiens_hsa000711.91788915
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91511184
27Tryptophan metabolism_Homo sapiens_hsa003801.90646141
28Pyruvate metabolism_Homo sapiens_hsa006201.78597792
29Chemical carcinogenesis_Homo sapiens_hsa052041.77502062
30Complement and coagulation cascades_Homo sapiens_hsa046101.76821808
31Histidine metabolism_Homo sapiens_hsa003401.75977577
32Parkinsons disease_Homo sapiens_hsa050121.75512256
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75175867
34RNA transport_Homo sapiens_hsa030131.74058652
35Arginine biosynthesis_Homo sapiens_hsa002201.73315884
36Folate biosynthesis_Homo sapiens_hsa007901.67293545
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65838707
38Butanoate metabolism_Homo sapiens_hsa006501.65221545
39N-Glycan biosynthesis_Homo sapiens_hsa005101.62780749
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.61042821
41Nucleotide excision repair_Homo sapiens_hsa034201.51383111
42Proteasome_Homo sapiens_hsa030501.50275929
43Protein export_Homo sapiens_hsa030601.49829262
44Mismatch repair_Homo sapiens_hsa034301.48207044
45Caffeine metabolism_Homo sapiens_hsa002321.46252556
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43905445
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.40844888
48beta-Alanine metabolism_Homo sapiens_hsa004101.36775007
49Linoleic acid metabolism_Homo sapiens_hsa005911.36734412
50PPAR signaling pathway_Homo sapiens_hsa033201.35625268
51mRNA surveillance pathway_Homo sapiens_hsa030151.34638439
52Notch signaling pathway_Homo sapiens_hsa043301.34364685
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32965188
54Fatty acid metabolism_Homo sapiens_hsa012121.32666730
55Phenylalanine metabolism_Homo sapiens_hsa003601.32499647
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32226293
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31340178
58Carbon metabolism_Homo sapiens_hsa012001.31210623
59Ribosome_Homo sapiens_hsa030101.28443458
60Other glycan degradation_Homo sapiens_hsa005111.27534019
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27375497
62Alzheimers disease_Homo sapiens_hsa050101.27199154
63Vitamin B6 metabolism_Homo sapiens_hsa007501.25402427
64Fructose and mannose metabolism_Homo sapiens_hsa000511.22841313
65Staphylococcus aureus infection_Homo sapiens_hsa051501.21719048
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21217549
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.20783720
68Glutathione metabolism_Homo sapiens_hsa004801.20412674
69Sulfur relay system_Homo sapiens_hsa041221.18962519
70Huntingtons disease_Homo sapiens_hsa050161.18081334
71Starch and sucrose metabolism_Homo sapiens_hsa005001.17064611
72Retinol metabolism_Homo sapiens_hsa008301.16899667
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15238419
74Nitrogen metabolism_Homo sapiens_hsa009101.09494386
75Maturity onset diabetes of the young_Homo sapiens_hsa049501.08007731
76Fat digestion and absorption_Homo sapiens_hsa049751.06145499
77Tyrosine metabolism_Homo sapiens_hsa003501.05422701
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05251589
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03691254
80Biosynthesis of amino acids_Homo sapiens_hsa012301.02178557
81Arachidonic acid metabolism_Homo sapiens_hsa005901.01854097
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00767081
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97775237
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95574523
85ABC transporters_Homo sapiens_hsa020100.94439319
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87376914
87Galactose metabolism_Homo sapiens_hsa000520.87006372
88Steroid biosynthesis_Homo sapiens_hsa001000.85415826
89Non-homologous end-joining_Homo sapiens_hsa034500.84506847
90Metabolic pathways_Homo sapiens_hsa011000.84085971
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81979618
92Lysine degradation_Homo sapiens_hsa003100.81477804
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80413908
94Arginine and proline metabolism_Homo sapiens_hsa003300.80349171
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.78450510
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76850149
97Pentose phosphate pathway_Homo sapiens_hsa000300.76751999
98Vitamin digestion and absorption_Homo sapiens_hsa049770.75926854
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.74058043
100Collecting duct acid secretion_Homo sapiens_hsa049660.72767027
101Basal transcription factors_Homo sapiens_hsa030220.72487826
102Lysosome_Homo sapiens_hsa041420.72067015
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71369125
104p53 signaling pathway_Homo sapiens_hsa041150.68713293
105One carbon pool by folate_Homo sapiens_hsa006700.64049389
106RNA degradation_Homo sapiens_hsa030180.63263823
107Glycerolipid metabolism_Homo sapiens_hsa005610.61716964
108Ether lipid metabolism_Homo sapiens_hsa005650.61051358
109Bile secretion_Homo sapiens_hsa049760.59092970
110Regulation of autophagy_Homo sapiens_hsa041400.58671743
111Shigellosis_Homo sapiens_hsa051310.57637324
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56884039
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55994324
114Epstein-Barr virus infection_Homo sapiens_hsa051690.55291771
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.55123547
116Renin-angiotensin system_Homo sapiens_hsa046140.53186060
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.50151763
118VEGF signaling pathway_Homo sapiens_hsa043700.43150601
119Cell cycle_Homo sapiens_hsa041100.43021785
120Bladder cancer_Homo sapiens_hsa052190.39485941
121Sphingolipid metabolism_Homo sapiens_hsa006000.38720075
122Pyrimidine metabolism_Homo sapiens_hsa002400.35079657
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33708255
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33403564
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33116003
126Basal cell carcinoma_Homo sapiens_hsa052170.31122609
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30188838
128Acute myeloid leukemia_Homo sapiens_hsa052210.29412695
129Apoptosis_Homo sapiens_hsa042100.28800470
130Cardiac muscle contraction_Homo sapiens_hsa042600.28646082
131Vibrio cholerae infection_Homo sapiens_hsa051100.28215811
132RNA polymerase_Homo sapiens_hsa030200.26641975
133AMPK signaling pathway_Homo sapiens_hsa041520.24994998
134Olfactory transduction_Homo sapiens_hsa047400.22178596
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22037844
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21553196
137Endocytosis_Homo sapiens_hsa041440.18561423
138Herpes simplex infection_Homo sapiens_hsa051680.18322155
139Phagosome_Homo sapiens_hsa041450.17664721
140Purine metabolism_Homo sapiens_hsa002300.16991654
141Rheumatoid arthritis_Homo sapiens_hsa053230.16379743
142Salmonella infection_Homo sapiens_hsa051320.16053294
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15922921
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15462764
145Inositol phosphate metabolism_Homo sapiens_hsa005620.15422691
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15133002
147African trypanosomiasis_Homo sapiens_hsa051430.14808502

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