NAV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.38729429
2vocalization behavior (GO:0071625)4.53937173
3layer formation in cerebral cortex (GO:0021819)4.46868862
4locomotory exploration behavior (GO:0035641)4.42886944
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38670998
6neuron recognition (GO:0008038)4.37276129
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30831051
8axonal fasciculation (GO:0007413)4.16240563
9dendritic spine morphogenesis (GO:0060997)4.10710041
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03652785
11dendrite morphogenesis (GO:0048813)4.02187453
12protein localization to synapse (GO:0035418)3.99088976
13synaptic vesicle maturation (GO:0016188)3.98774871
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.92256265
15cell migration in hindbrain (GO:0021535)3.92228012
16pyrimidine nucleobase catabolic process (GO:0006208)3.86697994
17regulation of glutamate receptor signaling pathway (GO:1900449)3.84072529
18exploration behavior (GO:0035640)3.80379432
19postsynaptic membrane organization (GO:0001941)3.76410766
20synaptic vesicle exocytosis (GO:0016079)3.71990324
21presynaptic membrane assembly (GO:0097105)3.69327031
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.67063495
23central nervous system projection neuron axonogenesis (GO:0021952)3.66406919
24regulation of synaptic vesicle exocytosis (GO:2000300)3.64243456
25axon extension involved in axon guidance (GO:0048846)3.53674876
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.53674876
27negative regulation of axon extension involved in axon guidance (GO:0048843)3.41012621
28presynaptic membrane organization (GO:0097090)3.41009408
29glutamate secretion (GO:0014047)3.37779575
30nucleobase catabolic process (GO:0046113)3.31870503
31regulation of synapse structural plasticity (GO:0051823)3.30656774
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28942187
33establishment of mitochondrion localization (GO:0051654)3.28886863
34glutamate receptor signaling pathway (GO:0007215)3.28697293
35regulation of axon extension involved in axon guidance (GO:0048841)3.27853703
36cerebral cortex radially oriented cell migration (GO:0021799)3.23212462
37regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18988960
38ganglion development (GO:0061548)3.15795092
39sequestering of extracellular ligand from receptor (GO:0035581)3.15448514
40positive regulation of synapse maturation (GO:0090129)3.14460688
41proline transport (GO:0015824)3.14156269
42transmission of nerve impulse (GO:0019226)3.12766590
43negative regulation of axon guidance (GO:1902668)3.12442511
44regulation of axon guidance (GO:1902667)3.10915270
45auditory behavior (GO:0031223)3.10702094
46synaptic transmission, glutamatergic (GO:0035249)3.10579594
47central nervous system neuron axonogenesis (GO:0021955)3.10170032
48synapse assembly (GO:0007416)3.08760350
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08032862
50tachykinin receptor signaling pathway (GO:0007217)3.07501888
51regulation of synaptic vesicle transport (GO:1902803)3.06585331
52mitochondrion transport along microtubule (GO:0047497)3.06538502
53establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06538502
54behavioral response to nicotine (GO:0035095)3.03288857
55nerve growth factor signaling pathway (GO:0038180)3.03138788
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01421227
57regulation of neuronal synaptic plasticity (GO:0048168)3.00992725
58substrate-independent telencephalic tangential migration (GO:0021826)3.00199703
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.00199703
60detection of calcium ion (GO:0005513)2.98284801
61innervation (GO:0060384)2.97560170
62axon extension (GO:0048675)2.97318139
63synaptic vesicle endocytosis (GO:0048488)2.95243841
64organelle transport along microtubule (GO:0072384)2.94499167
65synaptic vesicle docking involved in exocytosis (GO:0016081)2.89907200
66olfactory bulb development (GO:0021772)2.89504973
67response to auditory stimulus (GO:0010996)2.88782161
68behavioral response to ethanol (GO:0048149)2.88610342
69negative regulation of axon extension (GO:0030517)2.86718061
70regulation of dendritic spine morphogenesis (GO:0061001)2.86584521
71startle response (GO:0001964)2.86404119
72positive regulation of synapse assembly (GO:0051965)2.86390553
73urinary tract smooth muscle contraction (GO:0014848)2.86021802
74retinal ganglion cell axon guidance (GO:0031290)2.84754625
75neuron-neuron synaptic transmission (GO:0007270)2.84500774
76neurotransmitter secretion (GO:0007269)2.81953507
77cerebellar granule cell differentiation (GO:0021707)2.81876405
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80929826
79neurotransmitter-gated ion channel clustering (GO:0072578)2.80262736
80regulation of synapse maturation (GO:0090128)2.79473234
81synapse organization (GO:0050808)2.79212667
82negative chemotaxis (GO:0050919)2.79144439
83clathrin coat assembly (GO:0048268)2.76560660
84gamma-aminobutyric acid transport (GO:0015812)2.76190588
85negative regulation of axonogenesis (GO:0050771)2.75975612
86positive regulation of membrane potential (GO:0045838)2.74906090
87camera-type eye morphogenesis (GO:0048593)2.74683896
88neuronal ion channel clustering (GO:0045161)2.73690180
89neuronal action potential propagation (GO:0019227)2.72117836
90regulation of postsynaptic membrane potential (GO:0060078)2.71339639
91cerebellar Purkinje cell differentiation (GO:0021702)2.70891025
92regulation of neurotransmitter secretion (GO:0046928)2.70145102
93regulation of axon extension (GO:0030516)2.70019089
94positive regulation of dendritic spine development (GO:0060999)2.69773678
95regulation of respiratory system process (GO:0044065)2.69442365
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69189081
97regulation of dendritic spine development (GO:0060998)2.68476348
98hippocampus development (GO:0021766)2.68178853
99positive regulation of axon extension (GO:0045773)2.67902940
100vesicle transport along microtubule (GO:0047496)2.67807223
101negative regulation of microtubule polymerization (GO:0031115)2.66898965
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66452989
103dendritic spine organization (GO:0097061)2.66285924
104dendrite development (GO:0016358)2.65985560
105negative regulation of neurotransmitter transport (GO:0051589)2.65805979
106cardiac myofibril assembly (GO:0055003)2.64870914
107neuron projection extension (GO:1990138)2.64714577
108neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.64343439
109cerebellum development (GO:0021549)2.63022125
110regulation of vesicle fusion (GO:0031338)2.62792579
111adult walking behavior (GO:0007628)2.62518783
112positive regulation of action potential (GO:0045760)2.62490152
113spinal cord development (GO:0021510)2.61522160
114appendage development (GO:0048736)2.60941841
115limb development (GO:0060173)2.60941841
116bone trabecula formation (GO:0060346)2.59275386
117regulation of extent of cell growth (GO:0061387)2.59271481
118long-term memory (GO:0007616)2.58640310
119regulation of synapse assembly (GO:0051963)2.57401349
120activation of protein kinase A activity (GO:0034199)2.56241908
121regulation of synapse organization (GO:0050807)2.55644847
122neuromuscular process controlling balance (GO:0050885)2.55471423
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.55379192
124neuron projection morphogenesis (GO:0048812)2.54320919
125paraxial mesoderm development (GO:0048339)2.53560138
126body morphogenesis (GO:0010171)2.49442489
127negative regulation of catenin import into nucleus (GO:0035414)2.48556097
128embryonic body morphogenesis (GO:0010172)2.47542453
129calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47489797
130head development (GO:0060322)2.43996995
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43772650
132cell proliferation in forebrain (GO:0021846)2.41428932
133parturition (GO:0007567)2.40195057
134neurofilament cytoskeleton organization (GO:0060052)2.36162762
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.34952000
136lymphangiogenesis (GO:0001946)2.34630548
137mechanosensory behavior (GO:0007638)2.33419818
138positive regulation of cardiac muscle cell differentiation (GO:2000727)2.33121382
139cranial nerve morphogenesis (GO:0021602)2.32796627
140dermatan sulfate biosynthetic process (GO:0030208)2.30198589
141forebrain neuron differentiation (GO:0021879)2.28258598
142establishment of nucleus localization (GO:0040023)2.27596127
143central nervous system myelination (GO:0022010)2.27292899
144axon ensheathment in central nervous system (GO:0032291)2.27292899
145membrane assembly (GO:0071709)2.26895460
146cell aggregation (GO:0098743)2.26587725
147cartilage condensation (GO:0001502)2.26587725
148metanephric mesenchyme development (GO:0072075)2.25436033
149establishment or maintenance of monopolar cell polarity (GO:0061339)2.23623791
150establishment of monopolar cell polarity (GO:0061162)2.23623791
151regulation of synaptic transmission, GABAergic (GO:0032228)2.22785074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31805174
2GBX2_23144817_ChIP-Seq_PC3_Human3.59355337
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85715856
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81703555
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66420214
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.52505778
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49647030
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49647030
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36656516
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36617729
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32054312
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29993570
13DROSHA_22980978_ChIP-Seq_HELA_Human2.28503145
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22776381
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20242598
16REST_21632747_ChIP-Seq_MESCs_Mouse2.19654972
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19032945
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.13890576
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.13694616
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11008655
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99760000
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91332602
23AR_21572438_ChIP-Seq_LNCaP_Human1.89550373
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89280221
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86466147
26* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84516528
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84406722
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.80877386
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73209290
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.72637267
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63537679
32* REST_18959480_ChIP-ChIP_MESCs_Mouse1.62708703
33SMAD4_21799915_ChIP-Seq_A2780_Human1.61589972
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58108167
35TAF15_26573619_Chip-Seq_HEK293_Human1.58055445
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55328222
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55050105
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50750642
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50069323
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49283079
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47335214
42IGF1R_20145208_ChIP-Seq_DFB_Human1.45340771
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.44879350
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43549482
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43237210
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43075488
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43019378
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.42248400
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40189599
50P300_19829295_ChIP-Seq_ESCs_Human1.39026647
51ZNF274_21170338_ChIP-Seq_K562_Hela1.38976721
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.38230493
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38136764
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37677888
55AHR_22903824_ChIP-Seq_MCF-7_Human1.37427234
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34310164
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.34036165
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33159487
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32023685
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30676398
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30437749
62STAT3_23295773_ChIP-Seq_U87_Human1.30396385
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30309516
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.29454770
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.29227122
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.28455945
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.27238610
68* ISL1_27105846_Chip-Seq_CPCs_Mouse1.25499741
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24561707
70* WT1_19549856_ChIP-ChIP_CCG9911_Human1.24447429
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23986151
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23280697
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23128871
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.22333944
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21453746
76RNF2_27304074_Chip-Seq_NSC_Mouse1.17563061
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16191314
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14815550
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14815550
80* AR_19668381_ChIP-Seq_PC3_Human1.14671510
81AR_25329375_ChIP-Seq_VCAP_Human1.14530436
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14201966
83* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14082964
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12464150
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12433161
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12136576
87VDR_22108803_ChIP-Seq_LS180_Human1.11803325
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11552719
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10971248
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10822216
91RUNX2_22187159_ChIP-Seq_PCA_Human1.10481753
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10126104
93* TCF4_23295773_ChIP-Seq_U87_Human1.09965067
94* EP300_21415370_ChIP-Seq_HL-1_Mouse1.09870342
95* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08748446
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07887765
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07425868
98ER_23166858_ChIP-Seq_MCF-7_Human1.07385549
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.05191078
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04753962
101FUS_26573619_Chip-Seq_HEK293_Human1.04674994
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04278083
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.03932735
104TP53_16413492_ChIP-PET_HCT116_Human1.03313416
105* KDM2B_26808549_Chip-Seq_K562_Human1.02848312
106TP53_18474530_ChIP-ChIP_U2OS_Human1.02050291
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99923415
108* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99655861
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98830469
110SOX9_26525672_Chip-Seq_HEART_Mouse0.98516216
111* CJUN_26792858_Chip-Seq_BT549_Human0.98362315
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97892629
113* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97616333
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97608071
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96373030
116* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96213759
117JUN_21703547_ChIP-Seq_K562_Human0.95260730
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94374684
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.94264090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.79779274
2MP0003880_abnormal_central_pattern3.86071609
3MP0004270_analgesia3.78951095
4MP0003635_abnormal_synaptic_transmissio3.25739956
5MP0005423_abnormal_somatic_nervous2.94597030
6MP0000778_abnormal_nervous_system2.89121850
7MP0000569_abnormal_digit_pigmentation2.70349352
8MP0002734_abnormal_mechanical_nocicepti2.67218139
9MP0002063_abnormal_learning/memory/cond2.65206615
10MP0009745_abnormal_behavioral_response2.49066136
11MP0001968_abnormal_touch/_nociception2.47327419
12MP0002064_seizures2.37616570
13MP0004858_abnormal_nervous_system2.28705273
14MP0002735_abnormal_chemical_nociception2.28158634
15MP0002572_abnormal_emotion/affect_behav2.27788814
16MP0009046_muscle_twitch2.27096424
17MP0001486_abnormal_startle_reflex2.22491765
18MP0008438_abnormal_cutaneous_collagen2.20881579
19MP0002184_abnormal_innervation2.16736172
20MP0002733_abnormal_thermal_nociception2.06980914
21MP0006276_abnormal_autonomic_nervous2.02336179
22MP0002272_abnormal_nervous_system1.98745500
23MP0005503_abnormal_tendon_morphology1.93167777
24MP0002736_abnormal_nociception_after1.92225729
25MP0010030_abnormal_orbit_morphology1.90285687
26MP0001970_abnormal_pain_threshold1.88650410
27MP0001440_abnormal_grooming_behavior1.84198124
28MP0001984_abnormal_olfaction1.78569016
29MP0002067_abnormal_sensory_capabilities1.77402921
30MP0009780_abnormal_chondrocyte_physiolo1.76596492
31MP0000955_abnormal_spinal_cord1.74503802
32MP0004811_abnormal_neuron_physiology1.67791916
33MP0002557_abnormal_social/conspecific_i1.66145128
34MP0006292_abnormal_olfactory_placode1.62676999
35MP0001188_hyperpigmentation1.61727620
36MP0002882_abnormal_neuron_morphology1.59125335
37MP0005645_abnormal_hypothalamus_physiol1.58138535
38MP0003787_abnormal_imprinting1.53365365
39MP0004885_abnormal_endolymph1.49350373
40MP0003122_maternal_imprinting1.47729871
41MP0004924_abnormal_behavior1.46948505
42MP0005386_behavior/neurological_phenoty1.46948505
43MP0005409_darkened_coat_color1.46572489
44MP0003279_aneurysm1.43331606
45MP0005275_abnormal_skin_tensile1.40401418
46MP0000534_abnormal_ureter_morphology1.40358208
47MP0004742_abnormal_vestibular_system1.39909270
48MP0003123_paternal_imprinting1.38178810
49MP0005171_absent_coat_pigmentation1.35070794
50MP0000049_abnormal_middle_ear1.33612890
51MP0010386_abnormal_urinary_bladder1.32555473
52MP0000015_abnormal_ear_pigmentation1.31039950
53MP0010368_abnormal_lymphatic_system1.30986114
54MP0003942_abnormal_urinary_system1.30565804
55MP0009384_cardiac_valve_regurgitation1.30460296
56MP0002152_abnormal_brain_morphology1.30447761
57MP0001501_abnormal_sleep_pattern1.29463869
58MP0003890_abnormal_embryonic-extraembry1.29286905
59MP0004272_abnormal_basement_membrane1.28036543
60MP0003755_abnormal_palate_morphology1.27082820
61MP0009250_abnormal_appendicular_skeleto1.27077686
62MP0002066_abnormal_motor_capabilities/c1.27030711
63MP0003634_abnormal_glial_cell1.26535162
64MP0008569_lethality_at_weaning1.25418849
65MP0001905_abnormal_dopamine_level1.24911027
66MP0002233_abnormal_nose_morphology1.24243407
67MP0003329_amyloid_beta_deposits1.24228852
68MP0009053_abnormal_anal_canal1.21949029
69MP0003937_abnormal_limbs/digits/tail_de1.21106805
70MP0008775_abnormal_heart_ventricle1.20706444
71MP0002938_white_spotting1.18961402
72MP0000751_myopathy1.18309840
73MP0004133_heterotaxia1.17802726
74MP0000920_abnormal_myelination1.17613098
75MP0001958_emphysema1.16620551
76MP0002234_abnormal_pharynx_morphology1.14123772
77MP0004084_abnormal_cardiac_muscle1.13175099
78MP0005646_abnormal_pituitary_gland1.11998699
79MP0002909_abnormal_adrenal_gland1.10227091
80MP0005623_abnormal_meninges_morphology1.08813940
81MP0000631_abnormal_neuroendocrine_gland1.08703465
82MP0006072_abnormal_retinal_apoptosis1.08368631
83MP0004145_abnormal_muscle_electrophysio1.06934846
84MP0002752_abnormal_somatic_nervous1.06179226
85MP0001502_abnormal_circadian_rhythm1.02954873
86MP0003861_abnormal_nervous_system1.02668541
87MP0004142_abnormal_muscle_tone1.02224175
88MP0001299_abnormal_eye_distance/1.00484921
89MP0001529_abnormal_vocalization0.99216519
90MP0005499_abnormal_olfactory_system0.95234584
91MP0005394_taste/olfaction_phenotype0.95234584
92MP0002108_abnormal_muscle_morphology0.95028209
93MP0003119_abnormal_digestive_system0.93694882
94MP0002229_neurodegeneration0.93559474
95MP0003172_abnormal_lysosome_physiology0.93346527
96MP0003935_abnormal_craniofacial_develop0.92967780
97MP0004215_abnormal_myocardial_fiber0.92963319
98MP0003633_abnormal_nervous_system0.92418936
99MP0003631_nervous_system_phenotype0.92415743
100MP0002837_dystrophic_cardiac_calcinosis0.91394913
101MP0002116_abnormal_craniofacial_bone0.90989207
102MP0003632_abnormal_nervous_system0.90545287
103MP0002653_abnormal_ependyma_morphology0.89588357
104MP0005508_abnormal_skeleton_morphology0.89253263
105MP0001963_abnormal_hearing_physiology0.87431135
106MP0001879_abnormal_lymphatic_vessel0.87005072
107MP0005195_abnormal_posterior_eye0.86978306
108MP0004085_abnormal_heartbeat0.86876866
109MP0002822_catalepsy0.85741819
110MP0005257_abnormal_intraocular_pressure0.85512415
111MP0002932_abnormal_joint_morphology0.84774964
112MP0002751_abnormal_autonomic_nervous0.84462851
113MP0001348_abnormal_lacrimal_gland0.83639273
114MP0001485_abnormal_pinna_reflex0.82938044
115MP0005551_abnormal_eye_electrophysiolog0.81521099
116MP0004510_myositis0.80280051
117MP0003283_abnormal_digestive_organ0.79011786
118MP0005174_abnormal_tail_pigmentation0.76467817
119MP0003137_abnormal_impulse_conducting0.76257133
120MP0002638_abnormal_pupillary_reflex0.76235092
121MP0000026_abnormal_inner_ear0.75080011
122MP0005187_abnormal_penis_morphology0.73964413
123MP0003690_abnormal_glial_cell0.73081158
124MP0003385_abnormal_body_wall0.71822723
125MP0002069_abnormal_eating/drinking_beha0.71058943
126MP0003121_genomic_imprinting0.71023760
127MP0001177_atelectasis0.70401081
128MP0003879_abnormal_hair_cell0.69796594
129MP0002102_abnormal_ear_morphology0.69680957
130MP0008789_abnormal_olfactory_epithelium0.68002770
131MP0004134_abnormal_chest_morphology0.65983900
132MP0000013_abnormal_adipose_tissue0.63893309
133MP0003938_abnormal_ear_development0.63424216
134MP0001943_abnormal_respiration0.62849718
135MP0010770_preweaning_lethality0.61551201
136MP0002082_postnatal_lethality0.61551201

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.13552978
2Focal seizures (HP:0007359)4.01774587
3Focal motor seizures (HP:0011153)3.92827283
4Supranuclear gaze palsy (HP:0000605)3.67981724
5Epileptic encephalopathy (HP:0200134)3.58484506
6Abnormality of the corticospinal tract (HP:0002492)3.55636340
7Visual hallucinations (HP:0002367)3.52412135
8Limb dystonia (HP:0002451)3.31579519
9Progressive cerebellar ataxia (HP:0002073)3.18609199
10Mutism (HP:0002300)3.11204077
11Atonic seizures (HP:0010819)3.11013885
12Termporal pattern (HP:0011008)3.09976744
13Insidious onset (HP:0003587)3.09976744
14Drooling (HP:0002307)3.06512845
15Excessive salivation (HP:0003781)3.06512845
16Broad-based gait (HP:0002136)3.02252082
17Neurofibrillary tangles (HP:0002185)3.00095999
18Ankle clonus (HP:0011448)2.97033585
19Febrile seizures (HP:0002373)2.96295655
20Premature rupture of membranes (HP:0001788)2.86913920
21Absent speech (HP:0001344)2.86284947
22Cerebral inclusion bodies (HP:0100314)2.81562832
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.80912778
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80912778
25Urinary bladder sphincter dysfunction (HP:0002839)2.72231853
26Action tremor (HP:0002345)2.70122483
27Akinesia (HP:0002304)2.69270280
28Hyperventilation (HP:0002883)2.64854982
29Protrusio acetabuli (HP:0003179)2.60660225
30Spastic gait (HP:0002064)2.56612338
31Amblyopia (HP:0000646)2.55834084
32Broad metatarsal (HP:0001783)2.50818914
33Genetic anticipation (HP:0003743)2.50457511
34Aplasia/Hypoplasia of the brainstem (HP:0007362)2.49769666
35Hypoplasia of the brainstem (HP:0002365)2.49769666
36Agitation (HP:0000713)2.49331123
37Aqueductal stenosis (HP:0002410)2.40277258
38Hemiparesis (HP:0001269)2.38581266
39Absence seizures (HP:0002121)2.34745964
40Exotropia (HP:0000577)2.31461246
41Lower limb muscle weakness (HP:0007340)2.30260946
42Rib fusion (HP:0000902)2.28924728
43Hypoventilation (HP:0002791)2.28797675
44Inappropriate behavior (HP:0000719)2.28649247
45Obstructive sleep apnea (HP:0002870)2.26183157
46Amyotrophic lateral sclerosis (HP:0007354)2.26036264
47Dialeptic seizures (HP:0011146)2.25230831
48Generalized tonic-clonic seizures (HP:0002069)2.23903967
49Bladder diverticulum (HP:0000015)2.21928168
50Progressive inability to walk (HP:0002505)2.20370211
51Polyphagia (HP:0002591)2.19252911
52Truncal ataxia (HP:0002078)2.19086237
53Aortic dissection (HP:0002647)2.19041545
54Diplopia (HP:0000651)2.18804396
55Abnormality of binocular vision (HP:0011514)2.18804396
56Papilledema (HP:0001085)2.15356897
57Urinary urgency (HP:0000012)2.15226516
58Dysmetria (HP:0001310)2.14919406
59Soft skin (HP:0000977)2.13357744
60Gait imbalance (HP:0002141)2.13276853
61Shallow orbits (HP:0000586)2.11995358
62Epileptiform EEG discharges (HP:0011182)2.10996069
63Pachygyria (HP:0001302)2.10916892
64EEG with generalized epileptiform discharges (HP:0011198)2.10493837
65Impaired vibration sensation in the lower limbs (HP:0002166)2.10045739
66Abnormality of salivation (HP:0100755)2.09508739
67Neonatal short-limb short stature (HP:0008921)2.09355718
68Ulnar claw (HP:0001178)2.09004992
69Gaze-evoked nystagmus (HP:0000640)2.08387178
70Pheochromocytoma (HP:0002666)2.07447181
71Atrial fibrillation (HP:0005110)2.04838451
72Abnormality of midbrain morphology (HP:0002418)2.04454626
73Molar tooth sign on MRI (HP:0002419)2.04454626
74Megalencephaly (HP:0001355)2.04388659
75Hypsarrhythmia (HP:0002521)2.03979472
76Short 4th metacarpal (HP:0010044)2.02947999
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02947999
78Morphological abnormality of the middle ear (HP:0008609)2.02530882
79Renal duplication (HP:0000075)2.01858550
80Abnormality of dentin (HP:0010299)2.01005814
81Bowel diverticulosis (HP:0005222)2.00912140
82Poor eye contact (HP:0000817)2.00784448
83Lower limb amyotrophy (HP:0007210)1.99753592
84Atrophic scars (HP:0001075)1.97208595
85Protruding tongue (HP:0010808)1.97013947
86Vitreoretinal degeneration (HP:0000655)1.96618686
87Abnormal eating behavior (HP:0100738)1.96045344
88Retinal dysplasia (HP:0007973)1.95500154
89Hypoplastic ischia (HP:0003175)1.95493496
90Prolonged QT interval (HP:0001657)1.95186586
91Depression (HP:0000716)1.95027843
92Insomnia (HP:0100785)1.95017518
93Fetal akinesia sequence (HP:0001989)1.92048072
94Lissencephaly (HP:0001339)1.90234992
95Open mouth (HP:0000194)1.89199504
96Widely spaced teeth (HP:0000687)1.88482939
97Blue irides (HP:0000635)1.88262311
98Impaired social interactions (HP:0000735)1.88029955
99Abnormal social behavior (HP:0012433)1.88029955
100Stereotypic behavior (HP:0000733)1.88015756
101Shawl scrotum (HP:0000049)1.87908856
102Specific learning disability (HP:0001328)1.87279373
103Abnormality of the ischium (HP:0003174)1.86916172
104Apathy (HP:0000741)1.85654653
105Primary atrial arrhythmia (HP:0001692)1.85627797
106Inability to walk (HP:0002540)1.85543377
107Pancreatic fibrosis (HP:0100732)1.84335897
108Nephronophthisis (HP:0000090)1.83759991
109Wide anterior fontanel (HP:0000260)1.83449310
110Follicular hyperkeratosis (HP:0007502)1.82655174
111Torticollis (HP:0000473)1.82145729
112Genu recurvatum (HP:0002816)1.82074526
113Anxiety (HP:0000739)1.80979417
114Dysdiadochokinesis (HP:0002075)1.80648786
115Ankle contracture (HP:0006466)1.80126051
116Congenital malformation of the right heart (HP:0011723)1.79367147
117Double outlet right ventricle (HP:0001719)1.79367147
118Medial flaring of the eyebrow (HP:0010747)1.78882810
119Pulmonic stenosis (HP:0001642)1.78652963
120Bulbous nose (HP:0000414)1.77982785
121Scanning speech (HP:0002168)1.77963612
122Macroorchidism (HP:0000053)1.77515353
123Morphological abnormality of the pyramidal tract (HP:0002062)1.77261750
124Limited hip movement (HP:0008800)1.76990469
125Narrow nasal bridge (HP:0000446)1.76985702
126Abnormal pancreas size (HP:0012094)1.75878952
127Abnormality of the right ventricle (HP:0001707)1.75795999
128Broad long bones (HP:0005622)1.75596059
129Gastroesophageal reflux (HP:0002020)1.75353147
130Sporadic (HP:0003745)1.74803661
131Vascular tortuosity (HP:0004948)1.73602781
132Chorioretinal atrophy (HP:0000533)1.73240432
133Increased number of teeth (HP:0011069)1.72749160
134Abnormality of the lower motor neuron (HP:0002366)1.71895990
135Supraventricular arrhythmia (HP:0005115)1.71288916
136Peripheral hypomyelination (HP:0007182)1.71028753
137Aortic aneurysm (HP:0004942)1.70663675
138Wrist flexion contracture (HP:0001239)1.70528406
139Supraventricular tachycardia (HP:0004755)1.70200020
140Hepatoblastoma (HP:0002884)1.69823012
141Hip contracture (HP:0003273)1.68394444
142Bifid tongue (HP:0010297)1.67913029
143Steppage gait (HP:0003376)1.67578594
144Postural instability (HP:0002172)1.66988719
145Abnormal hair whorl (HP:0010721)1.66529835
146Broad phalanx (HP:0006009)1.66155893
147Cutaneous syndactyly (HP:0012725)1.65451540
148Hypoplasia of the corpus callosum (HP:0002079)1.65352487
149Bradycardia (HP:0001662)1.65049075
150Onion bulb formation (HP:0003383)1.64172777
151Cutaneous finger syndactyly (HP:0010554)1.64050302
152Intellectual disability, moderate (HP:0002342)1.63682117
153Neuroendocrine neoplasm (HP:0100634)1.63628627
154Keratoconus (HP:0000563)1.63619130
155Increased corneal curvature (HP:0100692)1.63619130
156Abnormality of the antihelix (HP:0009738)1.63458598
157Overgrowth (HP:0001548)1.63040382
158Flat cornea (HP:0007720)1.63011621
159Intestinal atresia (HP:0011100)1.62721108
160Abnormality of the 4th metacarpal (HP:0010012)1.62442650
161Arterial tortuosity (HP:0005116)1.62025609
162Type 1 muscle fiber predominance (HP:0003803)1.61281729
163Mesomelia (HP:0003027)1.60715492
164Anomalous pulmonary venous return (HP:0010772)1.59703309
165Left ventricular hypertrophy (HP:0001712)1.59235847
166Coronal craniosynostosis (HP:0004440)1.59213952
167Narrow forehead (HP:0000341)1.58063246
168Preaxial foot polydactyly (HP:0001841)1.57865504
169Vaginal atresia (HP:0000148)1.56802078
170Abnormality of the renal medulla (HP:0100957)1.56655108
171Congenital primary aphakia (HP:0007707)1.56560408
172Abnormality of the aortic arch (HP:0012303)1.55589914
173Broad ribs (HP:0000885)1.55267210
174Broad finger (HP:0001500)1.52998501
175Abnormality of the pulmonary veins (HP:0011718)1.52944590
176Genital tract atresia (HP:0001827)1.52717556
177Abnormality of the diencephalon (HP:0010662)1.51779070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.86972560
2NTRK33.11549187
3CASK2.93529282
4MAP3K92.51867095
5BMPR1B2.48999412
6MAP3K42.47525761
7MINK12.41159870
8FRK2.23062383
9MAPK132.22562724
10NTRK22.21431104
11EPHA42.11673399
12MAP2K72.05215828
13AKT32.03369832
14TNIK1.98158048
15WNK31.97262837
16PHKG21.94404588
17PHKG11.94404588
18DYRK21.81287861
19SIK21.79778476
20PAK61.77172728
21NTRK11.74827956
22DAPK21.71778926
23PNCK1.67534348
24PRPF4B1.61718373
25PLK21.48026016
26MYLK1.45669805
27UHMK11.45505720
28CSNK1G21.42499676
29CDK51.42026546
30PKN11.36280120
31PINK11.31687688
32TYRO31.27209041
33LATS21.26928633
34KSR11.24982559
35CAMK1G1.24438584
36ERBB31.23272631
37CSNK1A1L1.20360694
38ICK1.20232254
39CAMK1D1.17890845
40STK38L1.16089224
41MAP2K41.14362319
42CSNK1G31.14232101
43TIE11.12610042
44GRK51.11841792
45WNK41.10436371
46MUSK1.10365872
47ADRBK21.08995037
48PTK21.06208144
49FES1.05369321
50MARK21.03919938
51PAK31.02292890
52FGR0.98535031
53EPHB20.98485026
54PRKD30.96938323
55SGK2230.95064049
56SGK4940.95064049
57LATS10.91862106
58DMPK0.91115936
59STK390.90102207
60BCR0.89551026
61PIK3CA0.88636103
62INSRR0.88590396
63RIPK10.88396634
64LIMK10.87620378
65DYRK1A0.87488889
66OBSCN0.87138070
67PRKCE0.86799508
68CAMKK10.86673848
69CAMK2A0.84442376
70KSR20.83551802
71MAP3K20.82464992
72PRKCG0.82262545
73RET0.80636968
74RPS6KA20.79809659
75ARAF0.79104087
76GRK10.78159971
77CDK140.76728766
78CSNK1G10.74373549
79ADRBK10.74107404
80MKNK20.73919677
81STK110.72809547
82WNK10.71675663
83CDK180.71213038
84MET0.70708326
85CDK150.70042836
86DYRK30.69892182
87CDC42BPA0.68910123
88OXSR10.68807998
89SGK20.67705189
90PRKCZ0.64442109
91MAP3K60.64070935
92SGK10.63367217
93PRKCH0.63249743
94CAMK2B0.62495923
95FLT30.62455110
96PRKAA10.61285710
97CDK11A0.59381020
98DAPK10.58273006
99FYN0.57469684
100MAP3K120.56815051
101DYRK1B0.54554762
102PTK2B0.53654385
103ROCK20.52339253
104IRAK20.51452361
105PRKD20.51205559
106ROCK10.50829434
107FER0.50150731
108RIPK40.49558036
109PDGFRA0.49238098
110PAK20.47908486
111LMTK20.47601263
112TAOK10.47411066
113MAPK100.47163820
114CAMK2D0.46953478
115CAMK40.45279350
116BRAF0.44930345
117TGFBR10.44693490
118SGK30.44614226
119PRKG10.43434041
120STK380.43324818
121MTOR0.42242866
122ERBB20.41601212
123CAMKK20.40816852
124NEK60.40651093
125PDGFRB0.40122639
126MAPK90.39863246
127MAPK120.38936516
128DDR20.38542180
129FGFR20.38217675
130CAMK10.37346136
131RPS6KA30.37091030

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.68957335
2Synaptic vesicle cycle_Homo sapiens_hsa047212.35463896
3Circadian entrainment_Homo sapiens_hsa047132.31107090
4Glutamatergic synapse_Homo sapiens_hsa047242.28423143
5Olfactory transduction_Homo sapiens_hsa047402.27237277
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26324980
7GABAergic synapse_Homo sapiens_hsa047272.17230552
8Morphine addiction_Homo sapiens_hsa050322.16480778
9ECM-receptor interaction_Homo sapiens_hsa045122.10773530
10Axon guidance_Homo sapiens_hsa043602.06159122
11Dopaminergic synapse_Homo sapiens_hsa047282.02787150
12Cholinergic synapse_Homo sapiens_hsa047251.95882295
13Long-term potentiation_Homo sapiens_hsa047201.93453709
14Serotonergic synapse_Homo sapiens_hsa047261.89195470
15Amphetamine addiction_Homo sapiens_hsa050311.72917545
16Insulin secretion_Homo sapiens_hsa049111.69980002
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67990316
18Taste transduction_Homo sapiens_hsa047421.67977420
19Long-term depression_Homo sapiens_hsa047301.64339087
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53506176
21Salivary secretion_Homo sapiens_hsa049701.52590255
22Renin secretion_Homo sapiens_hsa049241.52510160
23Gap junction_Homo sapiens_hsa045401.49130485
24Cocaine addiction_Homo sapiens_hsa050301.47820948
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42549985
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41678297
27Oxytocin signaling pathway_Homo sapiens_hsa049211.36829287
28Gastric acid secretion_Homo sapiens_hsa049711.32681450
29GnRH signaling pathway_Homo sapiens_hsa049121.31511670
30Type II diabetes mellitus_Homo sapiens_hsa049301.29162014
31ErbB signaling pathway_Homo sapiens_hsa040121.22055026
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21543135
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19897107
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19772445
35Calcium signaling pathway_Homo sapiens_hsa040201.16941444
36Phototransduction_Homo sapiens_hsa047441.15929566
37Protein digestion and absorption_Homo sapiens_hsa049741.15117399
38Collecting duct acid secretion_Homo sapiens_hsa049661.14741206
39Estrogen signaling pathway_Homo sapiens_hsa049151.14193747
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14080975
41Glioma_Homo sapiens_hsa052141.13655090
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11632566
43cAMP signaling pathway_Homo sapiens_hsa040241.10660609
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05550645
45Melanogenesis_Homo sapiens_hsa049161.04765804
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04337779
47Dorso-ventral axis formation_Homo sapiens_hsa043201.02637476
48Endometrial cancer_Homo sapiens_hsa052131.01511820
49Renal cell carcinoma_Homo sapiens_hsa052110.97929153
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.97923367
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.97453640
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97074137
53Dilated cardiomyopathy_Homo sapiens_hsa054140.97070438
54Adherens junction_Homo sapiens_hsa045200.96537713
55Ras signaling pathway_Homo sapiens_hsa040140.95497962
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94564975
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94126212
58Notch signaling pathway_Homo sapiens_hsa043300.93106523
59Colorectal cancer_Homo sapiens_hsa052100.89656842
60Choline metabolism in cancer_Homo sapiens_hsa052310.89195504
61Vibrio cholerae infection_Homo sapiens_hsa051100.88655736
62TGF-beta signaling pathway_Homo sapiens_hsa043500.87432649
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85283705
64Lysine degradation_Homo sapiens_hsa003100.84814842
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.83786958
66MAPK signaling pathway_Homo sapiens_hsa040100.82009826
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.81237143
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80289287
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79526886
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77639326
71Cardiac muscle contraction_Homo sapiens_hsa042600.76861841
72Wnt signaling pathway_Homo sapiens_hsa043100.74527027
73VEGF signaling pathway_Homo sapiens_hsa043700.74360980
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74176666
75MicroRNAs in cancer_Homo sapiens_hsa052060.73773877
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73190774
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72890345
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72597970
79Rap1 signaling pathway_Homo sapiens_hsa040150.70611586
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69409393
81Proteoglycans in cancer_Homo sapiens_hsa052050.69126396
82Pathways in cancer_Homo sapiens_hsa052000.68981604
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67372736
84Oocyte meiosis_Homo sapiens_hsa041140.65844492
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65236530
86Hedgehog signaling pathway_Homo sapiens_hsa043400.64236385
87Endocytosis_Homo sapiens_hsa041440.64224520
88Pancreatic secretion_Homo sapiens_hsa049720.63674203
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63526742
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63244855
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61944146
92Ovarian steroidogenesis_Homo sapiens_hsa049130.59873702
93Tight junction_Homo sapiens_hsa045300.59391606
94Circadian rhythm_Homo sapiens_hsa047100.59176141
95Amoebiasis_Homo sapiens_hsa051460.57110658
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56811978
97Focal adhesion_Homo sapiens_hsa045100.55158306
98Chemokine signaling pathway_Homo sapiens_hsa040620.54888863
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54707678
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53599000
101Insulin signaling pathway_Homo sapiens_hsa049100.52070139
102Ether lipid metabolism_Homo sapiens_hsa005650.51502552
103Melanoma_Homo sapiens_hsa052180.51487016
104Alcoholism_Homo sapiens_hsa050340.51374856
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50897379
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50213504
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49866831
108Prion diseases_Homo sapiens_hsa050200.48714754
109AMPK signaling pathway_Homo sapiens_hsa041520.48024008
110mTOR signaling pathway_Homo sapiens_hsa041500.47811073
111Thyroid hormone synthesis_Homo sapiens_hsa049180.46564639
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46361435
113Phagosome_Homo sapiens_hsa041450.45466978
114Pancreatic cancer_Homo sapiens_hsa052120.45104659
115Hippo signaling pathway_Homo sapiens_hsa043900.44286601
116Butanoate metabolism_Homo sapiens_hsa006500.43877453
117Viral myocarditis_Homo sapiens_hsa054160.43825043
118Glucagon signaling pathway_Homo sapiens_hsa049220.43338530
119Alzheimers disease_Homo sapiens_hsa050100.42870048
120Basal cell carcinoma_Homo sapiens_hsa052170.42769383
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42240156
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42094986
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41346762
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41242233

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