NAV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.59234841
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43417141
3neuron cell-cell adhesion (GO:0007158)5.33063150
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09742801
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.83276826
6regulation of glutamate receptor signaling pathway (GO:1900449)4.80320311
7protein localization to synapse (GO:0035418)4.65475671
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.52300098
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50891683
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.29031497
11synaptic vesicle exocytosis (GO:0016079)4.27782102
12glutamate receptor signaling pathway (GO:0007215)4.14427647
13behavioral response to ethanol (GO:0048149)4.14031450
14presynaptic membrane assembly (GO:0097105)4.08725824
15axonal fasciculation (GO:0007413)4.08630336
16glutamate secretion (GO:0014047)4.08131020
17neuron recognition (GO:0008038)4.06611241
18locomotory exploration behavior (GO:0035641)3.99555543
19postsynaptic membrane organization (GO:0001941)3.98450573
20neurotransmitter-gated ion channel clustering (GO:0072578)3.98356071
21regulation of synaptic vesicle exocytosis (GO:2000300)3.97846229
22regulation of sarcomere organization (GO:0060297)3.96305970
23synaptic transmission, glutamatergic (GO:0035249)3.95732481
24neuronal action potential propagation (GO:0019227)3.92226992
25dendritic spine morphogenesis (GO:0060997)3.85461951
26synaptic vesicle maturation (GO:0016188)3.78861664
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78731180
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77442480
29proline transport (GO:0015824)3.76663968
30positive regulation of synapse maturation (GO:0090129)3.75169620
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71171509
32neuron-neuron synaptic transmission (GO:0007270)3.69245973
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64326686
34regulation of synaptic vesicle transport (GO:1902803)3.59600416
35presynaptic membrane organization (GO:0097090)3.57257241
36regulation of neuronal synaptic plasticity (GO:0048168)3.51850677
37positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.51759396
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.50553448
39central nervous system projection neuron axonogenesis (GO:0021952)3.48478506
40regulation of synapse maturation (GO:0090128)3.48071356
41layer formation in cerebral cortex (GO:0021819)3.47830828
42exploration behavior (GO:0035640)3.45547421
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.45547031
44regulation of postsynaptic membrane potential (GO:0060078)3.42169025
45long-term memory (GO:0007616)3.29947673
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.29687581
47regulation of synapse structural plasticity (GO:0051823)3.28733324
48behavioral response to nicotine (GO:0035095)3.28510752
49positive regulation of membrane potential (GO:0045838)3.27013621
50synaptic vesicle endocytosis (GO:0048488)3.26721762
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26594412
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25265872
53neurotransmitter secretion (GO:0007269)3.24315622
54synapse assembly (GO:0007416)3.17363145
55gamma-aminobutyric acid transport (GO:0015812)3.16344767
56regulation of dendritic spine morphogenesis (GO:0061001)3.14915383
57dendrite morphogenesis (GO:0048813)3.13025497
58cell migration in hindbrain (GO:0021535)3.12933125
59long-term synaptic potentiation (GO:0060291)3.11564488
60positive regulation of neurotransmitter secretion (GO:0001956)3.10436846
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09651439
62regulation of synaptic plasticity (GO:0048167)3.09178897
63innervation (GO:0060384)3.08577896
64startle response (GO:0001964)3.08114488
65regulation of neurotransmitter secretion (GO:0046928)3.07260910
66cerebral cortex radially oriented cell migration (GO:0021799)3.03978336
67response to auditory stimulus (GO:0010996)2.99012364
68cerebellar granule cell differentiation (GO:0021707)2.98874564
69positive regulation of synapse assembly (GO:0051965)2.96515540
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95697602
71regulation of dendritic spine development (GO:0060998)2.95371512
72membrane depolarization (GO:0051899)2.94150010
73cerebellar Purkinje cell differentiation (GO:0021702)2.93189873
74membrane assembly (GO:0071709)2.92819664
75positive regulation of cardiac muscle cell differentiation (GO:2000727)2.90494159
76dendritic spine organization (GO:0097061)2.90295780
77learning (GO:0007612)2.87264941
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83657362
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82963309
80central nervous system neuron axonogenesis (GO:0021955)2.82316258
81negative regulation of protein localization to cell surface (GO:2000009)2.82274664
82regulation of synapse assembly (GO:0051963)2.81036904
83membrane hyperpolarization (GO:0060081)2.80365849
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77988502
85regulation of respiratory system process (GO:0044065)2.77724120
86transmission of nerve impulse (GO:0019226)2.76060284
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74186329
88regulation of neurotransmitter transport (GO:0051588)2.73395074
89protein K11-linked deubiquitination (GO:0035871)2.73361834
90membrane depolarization during action potential (GO:0086010)2.72908322
91negative regulation of dendrite development (GO:2000171)2.72433226
92dendrite development (GO:0016358)2.71998892
93regulation of hippo signaling (GO:0035330)2.71329514
94regulation of synapse organization (GO:0050807)2.71016333
95regulation of synaptic transmission, GABAergic (GO:0032228)2.68496727
96positive regulation of neurotransmitter transport (GO:0051590)2.68333786
97nerve growth factor signaling pathway (GO:0038180)2.68328160
98auditory behavior (GO:0031223)2.68247318
99synapse organization (GO:0050808)2.68068608
100response to histamine (GO:0034776)2.67220897
101reflex (GO:0060004)2.67164061
102axon extension (GO:0048675)2.66171933
103pyrimidine nucleobase catabolic process (GO:0006208)2.66029583
104neurotransmitter transport (GO:0006836)2.65359241
105neuronal action potential (GO:0019228)2.64639373
106righting reflex (GO:0060013)2.63917724
107behavioral defense response (GO:0002209)2.63751982
108behavioral fear response (GO:0001662)2.63751982
109establishment of nucleus localization (GO:0040023)2.63309622
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62630299
111cochlea development (GO:0090102)2.61367080
112negative regulation of neurotransmitter transport (GO:0051589)2.61074869
113positive regulation of dendritic spine development (GO:0060999)2.60948190
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.60923646
115negative regulation of axon extension (GO:0030517)2.60811496
116tachykinin receptor signaling pathway (GO:0007217)2.60753773
117regulation of synaptic transmission (GO:0050804)2.60696108
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.60153776
119establishment of protein localization to Golgi (GO:0072600)2.58337229
120neuromuscular synaptic transmission (GO:0007274)2.55621122
121response to gravity (GO:0009629)2.55425659
122negative regulation of mast cell activation (GO:0033004)2.49732207
123alanine transport (GO:0032328)2.45971848
124fear response (GO:0042596)2.45184207
125detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44814022
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43735695
127lymphangiogenesis (GO:0001946)2.43514466
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42989207
129negative regulation of translation, ncRNA-mediated (GO:0040033)2.42989207
130regulation of translation, ncRNA-mediated (GO:0045974)2.42989207
131appendage development (GO:0048736)2.41830105
132limb development (GO:0060173)2.41830105
133negative regulation of axon guidance (GO:1902668)2.40035467
134regulation of action potential (GO:0098900)2.39405101
135nucleus localization (GO:0051647)2.39389563
136regulation of axon guidance (GO:1902667)2.39195118
137C4-dicarboxylate transport (GO:0015740)2.38201882
138regulation of pigment cell differentiation (GO:0050932)2.37780697
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.37547926
140detection of light stimulus involved in sensory perception (GO:0050962)2.35820437
141detection of light stimulus involved in visual perception (GO:0050908)2.35820437
142serotonin metabolic process (GO:0042428)2.34705668
143cerebral cortex cell migration (GO:0021795)2.34340317
144positive regulation of muscle hypertrophy (GO:0014742)2.33720205
145positive regulation of cardiac muscle hypertrophy (GO:0010613)2.33720205
146primary amino compound metabolic process (GO:1901160)2.33132596
147negative chemotaxis (GO:0050919)2.32608106
148cardiac myofibril assembly (GO:0055003)2.31142563
149lipid translocation (GO:0034204)2.31045614
150phospholipid translocation (GO:0045332)2.31045614
151regulation of axon extension involved in axon guidance (GO:0048841)2.30823596
152positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.28910956
153response to pheromone (GO:0019236)2.28373538
154retinal cone cell development (GO:0046549)2.27875524
155sequestering of extracellular ligand from receptor (GO:0035581)2.27747629
156L-amino acid import (GO:0043092)2.27032000
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.26269675
158pericardium development (GO:0060039)2.25677956
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.24960724
160Rac protein signal transduction (GO:0016601)2.24920692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44694461
2GBX2_23144817_ChIP-Seq_PC3_Human4.24733078
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81306551
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80316032
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62530658
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.43812102
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41651262
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39677540
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39677540
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32035712
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27734396
12DROSHA_22980978_ChIP-Seq_HELA_Human2.21296859
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20133300
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.17974569
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.14204813
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10941272
17AR_21572438_ChIP-Seq_LNCaP_Human2.08780819
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.08181790
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.05047375
20* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04473676
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03821784
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03645034
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03608415
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03147846
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97684043
26TAF15_26573619_Chip-Seq_HEK293_Human1.94456432
27* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89674927
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.85328044
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85225657
30SMAD4_21799915_ChIP-Seq_A2780_Human1.82231239
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81886234
32* P300_19829295_ChIP-Seq_ESCs_Human1.76658003
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74337175
34* SMAD_19615063_ChIP-ChIP_OVARY_Human1.71796898
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.69534458
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.66403122
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64004312
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.62824002
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.62274972
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.60879171
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60776899
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60096304
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56116809
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.52565126
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51368544
46AR_25329375_ChIP-Seq_VCAP_Human1.51004339
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50618611
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46451685
49* EWS_26573619_Chip-Seq_HEK293_Human1.45086629
50STAT3_23295773_ChIP-Seq_U87_Human1.44242529
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.43130261
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43010255
53IGF1R_20145208_ChIP-Seq_DFB_Human1.41980494
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40460363
55* CBP_20019798_ChIP-Seq_JUKART_Human1.40428714
56* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40428714
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40092058
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40039148
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39803139
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39685089
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38895633
62ZNF274_21170338_ChIP-Seq_K562_Hela1.38856595
63FUS_26573619_Chip-Seq_HEK293_Human1.38565461
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38418806
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36143354
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35864294
67AHR_22903824_ChIP-Seq_MCF-7_Human1.33892015
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33371477
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32763432
70* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30223494
71CJUN_26792858_Chip-Seq_BT549_Human1.30060997
72RNF2_27304074_Chip-Seq_NSC_Mouse1.29703585
73TCF4_23295773_ChIP-Seq_U87_Human1.28089181
74* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27895636
75* TP53_16413492_ChIP-PET_HCT116_Human1.27750654
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27677604
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27657239
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27657239
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26500480
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26500480
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23225579
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22427062
83KDM2B_26808549_Chip-Seq_REH_Human1.21489430
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.20343653
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.19947813
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19486942
87* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19460532
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19279331
89VDR_22108803_ChIP-Seq_LS180_Human1.18866745
90RUNX2_22187159_ChIP-Seq_PCA_Human1.18542960
91ER_23166858_ChIP-Seq_MCF-7_Human1.18491657
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.18151912
93* AR_19668381_ChIP-Seq_PC3_Human1.17713174
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17572701
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17217863
96TP53_18474530_ChIP-ChIP_U2OS_Human1.17074064
97* TCF4_22108803_ChIP-Seq_LS180_Human1.16069319
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.15587642
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14055892
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13596958
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13572080
102P53_22387025_ChIP-Seq_ESCs_Mouse1.12724782
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12533282
104* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12513012
105* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11437901
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10943056
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10288881
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.10099626
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10077364
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09564588
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.08851891
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08786236
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.07667436
114BCAT_22108803_ChIP-Seq_LS180_Human1.05316922
115* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05314743
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05254239
117* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05096111
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.02936353
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.01732847
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01265008
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00941826
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.00399045
123* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99881666
124* JUN_21703547_ChIP-Seq_K562_Human0.99633652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.54376554
2MP0003880_abnormal_central_pattern4.56504656
3MP0003635_abnormal_synaptic_transmissio3.67236985
4MP0003950_abnormal_plasma_membrane3.45306850
5MP0004270_analgesia3.29242991
6MP0002063_abnormal_learning/memory/cond3.06169561
7MP0001968_abnormal_touch/_nociception3.05566559
8MP0009745_abnormal_behavioral_response3.04067071
9MP0002064_seizures2.87276447
10MP0009046_muscle_twitch2.73863026
11MP0002572_abnormal_emotion/affect_behav2.72220608
12MP0005423_abnormal_somatic_nervous2.63481314
13MP0002736_abnormal_nociception_after2.63149949
14MP0000569_abnormal_digit_pigmentation2.57784418
15MP0001486_abnormal_startle_reflex2.53513073
16MP0000778_abnormal_nervous_system2.50645109
17MP0002734_abnormal_mechanical_nocicepti2.42421968
18MP0002735_abnormal_chemical_nociception2.32902493
19MP0003787_abnormal_imprinting2.20439375
20MP0002272_abnormal_nervous_system2.13926932
21MP0002067_abnormal_sensory_capabilities1.99176507
22MP0001501_abnormal_sleep_pattern1.98531526
23MP0002184_abnormal_innervation1.97685294
24MP0001440_abnormal_grooming_behavior1.95240165
25MP0002557_abnormal_social/conspecific_i1.90358650
26MP0005646_abnormal_pituitary_gland1.86617632
27MP0006276_abnormal_autonomic_nervous1.85409344
28MP0005645_abnormal_hypothalamus_physiol1.80638365
29MP0002733_abnormal_thermal_nociception1.80420425
30MP0002822_catalepsy1.75061099
31MP0001188_hyperpigmentation1.72231108
32MP0004924_abnormal_behavior1.71049388
33MP0005386_behavior/neurological_phenoty1.71049388
34MP0001970_abnormal_pain_threshold1.70774616
35MP0000749_muscle_degeneration1.65159591
36MP0002102_abnormal_ear_morphology1.64047297
37MP0009780_abnormal_chondrocyte_physiolo1.64041947
38MP0004811_abnormal_neuron_physiology1.55361705
39MP0005503_abnormal_tendon_morphology1.52902957
40MP0003879_abnormal_hair_cell1.52071333
41MP0004858_abnormal_nervous_system1.50143133
42MP0008438_abnormal_cutaneous_collagen1.46175961
43MP0001984_abnormal_olfaction1.42950643
44MP0000955_abnormal_spinal_cord1.42947644
45MP0004043_abnormal_pH_regulation1.40322662
46MP0008569_lethality_at_weaning1.38996068
47MP0006292_abnormal_olfactory_placode1.34568429
48MP0004742_abnormal_vestibular_system1.34480032
49MP0002882_abnormal_neuron_morphology1.34141937
50MP0005171_absent_coat_pigmentation1.31161881
51MP0000427_abnormal_hair_cycle1.28876990
52MP0005253_abnormal_eye_physiology1.27692859
53MP0002066_abnormal_motor_capabilities/c1.25821531
54MP0001529_abnormal_vocalization1.23843337
55MP0003122_maternal_imprinting1.23167349
56MP0004885_abnormal_endolymph1.21672016
57MP0004084_abnormal_cardiac_muscle1.21511611
58MP0004145_abnormal_muscle_electrophysio1.20470226
59MP0002152_abnormal_brain_morphology1.19864174
60MP0005595_abnormal_vascular_smooth1.16948848
61MP0001502_abnormal_circadian_rhythm1.16758288
62MP0003195_calcinosis1.12095736
63MP0009384_cardiac_valve_regurgitation1.10310203
64MP0008004_abnormal_stomach_pH1.10006488
65MP0003045_fibrosis1.09700189
66MP0006072_abnormal_retinal_apoptosis1.09300378
67MP0000538_abnormal_urinary_bladder1.07742959
68MP0000534_abnormal_ureter_morphology1.07188212
69MP0000631_abnormal_neuroendocrine_gland1.05820388
70MP0005187_abnormal_penis_morphology1.05818350
71MP0003633_abnormal_nervous_system1.05275522
72MP0002638_abnormal_pupillary_reflex1.02473440
73MP0002108_abnormal_muscle_morphology1.02394171
74MP0009250_abnormal_appendicular_skeleto1.01258409
75MP0003942_abnormal_urinary_system1.01137245
76MP0000230_abnormal_systemic_arterial1.00957746
77MP0000015_abnormal_ear_pigmentation1.00470412
78MP0010386_abnormal_urinary_bladder0.99856303
79MP0001963_abnormal_hearing_physiology0.97674179
80MP0004142_abnormal_muscle_tone0.96812685
81MP0004134_abnormal_chest_morphology0.96382050
82MP0005620_abnormal_muscle_contractility0.93739773
83MP0003279_aneurysm0.93614144
84MP0001986_abnormal_taste_sensitivity0.93589118
85MP0001177_atelectasis0.93171284
86MP0004085_abnormal_heartbeat0.92191422
87MP0003937_abnormal_limbs/digits/tail_de0.91367209
88MP0001542_abnormal_bone_strength0.91310690
89MP0003631_nervous_system_phenotype0.90702233
90MP0000751_myopathy0.88926202
91MP0002938_white_spotting0.88622259
92MP0005409_darkened_coat_color0.88507719
93MP0002168_other_aberrant_phenotype0.88329970
94MP0009053_abnormal_anal_canal0.87421060
95MP0001905_abnormal_dopamine_level0.86787800
96MP0005195_abnormal_posterior_eye0.85768632
97MP0003861_abnormal_nervous_system0.85264107
98MP0003755_abnormal_palate_morphology0.85136474
99MP0003121_genomic_imprinting0.84070968
100MP0010368_abnormal_lymphatic_system0.83617260
101MP0004484_altered_response_of0.83614312
102MP0005275_abnormal_skin_tensile0.83129169
103MP0003938_abnormal_ear_development0.82848857
104MP0002909_abnormal_adrenal_gland0.82437175
105MP0001958_emphysema0.81807653
106MP0008877_abnormal_DNA_methylation0.81440935
107MP0002069_abnormal_eating/drinking_beha0.80449951
108MP0005174_abnormal_tail_pigmentation0.80319530
109MP0004133_heterotaxia0.80216791
110MP0000639_abnormal_adrenal_gland0.79967751
111MP0004272_abnormal_basement_membrane0.79881543
112MP0000026_abnormal_inner_ear0.79554534
113MP0002752_abnormal_somatic_nervous0.79247054
114MP0003283_abnormal_digestive_organ0.79237880
115MP0002837_dystrophic_cardiac_calcinosis0.79052973
116MP0001299_abnormal_eye_distance/0.78494379
117MP0006054_spinal_hemorrhage0.77638017
118MP0001485_abnormal_pinna_reflex0.76980595
119MP0005551_abnormal_eye_electrophysiolog0.76780533
120MP0000049_abnormal_middle_ear0.75378576
121MP0003634_abnormal_glial_cell0.70022555
122MP0000566_synostosis0.69728129
123MP0008874_decreased_physiological_sensi0.68322121
124MP0002751_abnormal_autonomic_nervous0.67000095
125MP0002229_neurodegeneration0.65519378
126MP0003329_amyloid_beta_deposits0.63829366
127MP0002234_abnormal_pharynx_morphology0.61120848
128MP0004215_abnormal_myocardial_fiber0.61058840
129MP0003632_abnormal_nervous_system0.60483761
130MP0003137_abnormal_impulse_conducting0.58301514
131MP0003690_abnormal_glial_cell0.58139928
132MP0005499_abnormal_olfactory_system0.57391415
133MP0005394_taste/olfaction_phenotype0.57391415
134MP0002082_postnatal_lethality0.57260252
135MP0010770_preweaning_lethality0.57260252
136MP0008872_abnormal_physiological_respon0.56876786
137MP0001664_abnormal_digestion0.56804711
138MP0003385_abnormal_body_wall0.56213742
139MP0002116_abnormal_craniofacial_bone0.55454169
140MP0001943_abnormal_respiration0.54186355

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.18352261
2Focal seizures (HP:0007359)5.05491209
3Epileptic encephalopathy (HP:0200134)4.91984446
4Hyperventilation (HP:0002883)4.54885186
5Febrile seizures (HP:0002373)4.44638381
6Atonic seizures (HP:0010819)4.09697272
7Broad-based gait (HP:0002136)3.81594301
8Myokymia (HP:0002411)3.79624155
9Progressive cerebellar ataxia (HP:0002073)3.67566815
10Visual hallucinations (HP:0002367)3.40878931
11Excessive salivation (HP:0003781)3.29259418
12Drooling (HP:0002307)3.29259418
13Absence seizures (HP:0002121)3.19214412
14Pancreatic cysts (HP:0001737)3.16947941
15Absent speech (HP:0001344)3.15508002
16Aortic aneurysm (HP:0004942)3.14767025
17Dialeptic seizures (HP:0011146)3.11798921
18Generalized tonic-clonic seizures (HP:0002069)3.06449012
19Mutism (HP:0002300)3.03423651
20Hypoplastic ischia (HP:0003175)2.95281187
21Gaze-evoked nystagmus (HP:0000640)2.91234710
22Protruding tongue (HP:0010808)2.88476887
23Aortic dissection (HP:0002647)2.80706412
24Pancreatic fibrosis (HP:0100732)2.79978244
25Abnormality of midbrain morphology (HP:0002418)2.77722541
26Molar tooth sign on MRI (HP:0002419)2.77722541
27Blue irides (HP:0000635)2.75994191
28Amblyopia (HP:0000646)2.75496773
29True hermaphroditism (HP:0010459)2.74115813
30Abnormality of the ischium (HP:0003174)2.72619481
31Increased corneal curvature (HP:0100692)2.72197092
32Keratoconus (HP:0000563)2.72197092
33Aqueductal stenosis (HP:0002410)2.71449032
34Poor eye contact (HP:0000817)2.71316429
35Type 2 muscle fiber atrophy (HP:0003554)2.66497316
36Action tremor (HP:0002345)2.66450117
37Exotropia (HP:0000577)2.63996477
38Genetic anticipation (HP:0003743)2.60311497
39Abnormality of the neuromuscular junction (HP:0003398)2.53750917
40Fatigable weakness (HP:0003473)2.53750917
41Inability to walk (HP:0002540)2.52944682
42Epileptiform EEG discharges (HP:0011182)2.51671002
43Truncal ataxia (HP:0002078)2.51154882
44Generalized hypopigmentation of hair (HP:0011358)2.48696365
45Nephronophthisis (HP:0000090)2.44095294
46Inappropriate behavior (HP:0000719)2.43958208
47Morphological abnormality of the middle ear (HP:0008609)2.39862570
48Fetal akinesia sequence (HP:0001989)2.39517770
49Fair hair (HP:0002286)2.38840739
50Polyphagia (HP:0002591)2.37271194
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.37010313
52Abnormal eating behavior (HP:0100738)2.34580641
53Obstructive sleep apnea (HP:0002870)2.34244566
54Popliteal pterygium (HP:0009756)2.32668683
55EEG with generalized epileptiform discharges (HP:0011198)2.32244027
56Abnormality of salivation (HP:0100755)2.31826366
57Abnormal social behavior (HP:0012433)2.31529481
58Impaired social interactions (HP:0000735)2.31529481
59Impaired vibration sensation in the lower limbs (HP:0002166)2.30839914
60Urinary bladder sphincter dysfunction (HP:0002839)2.28197130
61Cystic liver disease (HP:0006706)2.27998236
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.24588217
63Progressive inability to walk (HP:0002505)2.23851018
64Gastroesophageal reflux (HP:0002020)2.22489419
65Decreased muscle mass (HP:0003199)2.20170081
66Widely spaced teeth (HP:0000687)2.19630709
67Hypsarrhythmia (HP:0002521)2.17039988
68Attenuation of retinal blood vessels (HP:0007843)2.15276499
69Congenital sensorineural hearing impairment (HP:0008527)2.13994706
70Urethral obstruction (HP:0000796)2.13892824
71Stereotypic behavior (HP:0000733)2.13193589
72Prolonged QT interval (HP:0001657)2.12415283
73Chorioretinal atrophy (HP:0000533)2.12009820
74Abnormality of the renal medulla (HP:0100957)2.11471352
75Narrow nasal bridge (HP:0000446)2.10465867
76Long nose (HP:0003189)2.10023822
77Hemiparesis (HP:0001269)2.09773895
78Aplasia of the musculature (HP:0100854)2.09381861
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.08762197
80Genital tract atresia (HP:0001827)2.08310102
81Termporal pattern (HP:0011008)2.07587839
82Insidious onset (HP:0003587)2.07587839
83Bulbous nose (HP:0000414)2.07398639
84Gait imbalance (HP:0002141)2.05869690
85Increased number of teeth (HP:0011069)2.03199718
86Dysdiadochokinesis (HP:0002075)2.02374604
87Abnormality of binocular vision (HP:0011514)2.00865196
88Diplopia (HP:0000651)2.00865196
89Type II lissencephaly (HP:0007260)1.99915245
90Dysmetria (HP:0001310)1.99578936
91Abolished electroretinogram (ERG) (HP:0000550)1.99547311
92Impaired smooth pursuit (HP:0007772)1.98742089
93Bile duct proliferation (HP:0001408)1.94211109
94Abnormal biliary tract physiology (HP:0012439)1.94211109
95Intestinal atresia (HP:0011100)1.92792489
96Vaginal atresia (HP:0000148)1.92657288
97Short chin (HP:0000331)1.91543154
98Sleep apnea (HP:0010535)1.91154351
99Abnormal hair whorl (HP:0010721)1.89150836
100Thickened helices (HP:0000391)1.89036760
101Congenital stationary night blindness (HP:0007642)1.88815026
102Aplasia/Hypoplasia of the lens (HP:0008063)1.88799718
103Chronic hepatic failure (HP:0100626)1.88484136
104Absent eyebrow (HP:0002223)1.88212267
105Gowers sign (HP:0003391)1.88097987
106Retinal dysplasia (HP:0007973)1.87668294
107Small hand (HP:0200055)1.87165859
108Short foot (HP:0001773)1.85454218
109Midline defect of the nose (HP:0004122)1.85441789
110Muscle fiber atrophy (HP:0100295)1.85249334
111Abnormality of the pubic bones (HP:0003172)1.84338735
112Limb dystonia (HP:0002451)1.84195239
113Autism (HP:0000717)1.83657836
114Arterial tortuosity (HP:0005116)1.83652867
115Open mouth (HP:0000194)1.82490201
116Absent/shortened dynein arms (HP:0200106)1.82001334
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.82001334
118Abnormality of the renal cortex (HP:0011035)1.81538331
119Limited hip movement (HP:0008800)1.81451207
120Specific learning disability (HP:0001328)1.80885805
121Hemiplegia (HP:0002301)1.80276605
122Ulnar claw (HP:0001178)1.79942950
123Left ventricular hypertrophy (HP:0001712)1.79856259
124Pachygyria (HP:0001302)1.79587920
125Abnormality of the corticospinal tract (HP:0002492)1.79088362
126Depression (HP:0000716)1.78273148
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77640701
128Hypoplasia of the brainstem (HP:0002365)1.77640701
129Depressed nasal tip (HP:0000437)1.77005787
130Tented upper lip vermilion (HP:0010804)1.76301337
131Wrist flexion contracture (HP:0001239)1.75669237
132Ankle clonus (HP:0011448)1.75109233
133Supranuclear gaze palsy (HP:0000605)1.73998212
134Abnormality of macular pigmentation (HP:0008002)1.73992161
135Deeply set eye (HP:0000490)1.73314409
136Preaxial foot polydactyly (HP:0001841)1.72803387
137Incomplete penetrance (HP:0003829)1.72609748
138Anosmia (HP:0000458)1.69370279
139Delayed gross motor development (HP:0002194)1.68951164
140Bony spicule pigmentary retinopathy (HP:0007737)1.68517341
141Macroglossia (HP:0000158)1.68438673
142Postural instability (HP:0002172)1.67067262
143Soft skin (HP:0000977)1.65731137
144Overgrowth (HP:0001548)1.65037036
145Hypoplastic iliac wings (HP:0002866)1.64972089
146Bradycardia (HP:0001662)1.64409468
147Optic nerve hypoplasia (HP:0000609)1.64226233
148Vascular tortuosity (HP:0004948)1.62919026
149Abnormality of ocular smooth pursuit (HP:0000617)1.62824094
150Abnormality of the nasal septum (HP:0000419)1.62317847
151Medial flaring of the eyebrow (HP:0010747)1.61667604
152Lower limb asymmetry (HP:0100559)1.61016395
153Lissencephaly (HP:0001339)1.60942133
154Intellectual disability, severe (HP:0010864)1.60205914
155Lower limb muscle weakness (HP:0007340)1.59636178
156Congenital primary aphakia (HP:0007707)1.59022949
157Nephrogenic diabetes insipidus (HP:0009806)1.58523695
158Submucous cleft hard palate (HP:0000176)1.57775682
159Abnormality of the labia minora (HP:0012880)1.57520817
160Cerebral aneurysm (HP:0004944)1.57484362
161Heterochromia iridis (HP:0001100)1.57237870
162Anxiety (HP:0000739)1.56801623
163Hyperthyroidism (HP:0000836)1.56718811
164Postaxial hand polydactyly (HP:0001162)1.56666546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.40462430
2MUSK4.93330030
3MARK13.87229277
4NTRK33.80988922
5EPHA43.76302231
6CASK3.72177531
7MAP3K43.36442403
8MAP2K73.02980496
9MAP3K92.62651106
10PRPF4B2.30234409
11MINK12.18400156
12NTRK22.13478804
13SIK22.11096070
14SIK32.03686809
15MAP2K42.01528428
16RIPK41.97032617
17MAPK131.95863971
18KSR11.87155726
19DAPK21.83848501
20PAK61.83847821
21TNIK1.83811525
22PLK21.79476973
23MAP3K121.78421580
24PINK11.62477310
25TAOK31.48475064
26GRK71.44785019
27MYLK1.43181905
28CAMK1G1.41132538
29PNCK1.34893242
30LIMK11.30983473
31SGK21.24829970
32CDK51.24174585
33LATS21.23464152
34DAPK11.21066160
35MAP3K61.20806535
36NUAK11.20640105
37TYRO31.15066955
38CAMKK11.09964347
39GRK51.09693758
40AKT31.08793865
41FGFR21.06306419
42DMPK1.03185165
43GRK11.01974271
44SGK2231.01972917
45SGK4941.01972917
46CAMK2A0.97980228
47STK390.96283949
48CAMKK20.95181238
49CAMK10.95062463
50ACVR1B0.93594147
51CDK30.93569807
52MAP4K20.93023092
53PTK2B0.90628709
54CAMK1D0.88166359
55PIK3CG0.87442024
56CDK190.84718271
57CCNB10.83217389
58PRKD30.81506947
59PRKCG0.81429301
60SGK30.80924130
61ROCK10.79368703
62STK380.79022896
63FES0.78494499
64DYRK1A0.78342460
65RET0.77306576
66BMPR20.76420428
67CAMK40.75560778
68UHMK10.75396630
69NTRK10.74162466
70SGK10.73599225
71TGFBR20.70195867
72CAMK2B0.69504360
73STK110.69057768
74KSR20.67858447
75MARK20.67036271
76FGR0.65418114
77CSNK1A1L0.65142650
78PRKCE0.64248574
79CDK180.63777321
80WNK40.61811908
81LATS10.59597956
82BMPR1B0.59010387
83FER0.58276325
84CSNK1G20.58104883
85FLT30.57192135
86CDK150.55951204
87DYRK20.54898788
88PHKG10.54104562
89PHKG20.54104562
90PAK30.53704192
91WNK10.52871321
92TAOK20.50645396
93EPHB20.50371500
94NEK60.50081471
95MKNK20.49073116
96STK38L0.48654796
97TRPM70.48387628
98OXSR10.48226646
99YES10.48023889
100PRKCZ0.47885615
101TRIM280.47438603
102CDK11A0.47051814
103CDK80.46955810
104PKN10.46356042
105CDC42BPA0.46336206
106MET0.45784495
107TIE10.45163790
108MAPK120.45103491
109CAMK2D0.44444357
110INSRR0.44418978
111RAF10.44418251
112CDK140.44310372
113ADRBK20.43049260
114PDGFRB0.42574950
115BCR0.42474893
116PDGFRA0.42416331
117PTK20.42376068
118PAK20.41502794
119PRKACB0.40733877
120ERBB30.40642367
121ERBB40.39948225
122CSNK1D0.39769322
123WNK30.39438158
124PRKCH0.39320998
125TGFBR10.38733641
126ROCK20.38339669
127ABL10.37876992
128MAPK150.37415697
129PIK3CA0.37362611
130MAP2K10.37300955
131CSNK1G10.37201855
132PRKG10.37034571
133MAPK100.36974207
134MAPKAPK50.36730685
135DDR20.35281371
136RPS6KA30.35221862
137ADRBK10.35045730
138PRKAA10.34989146

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76927231
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71043323
3Synaptic vesicle cycle_Homo sapiens_hsa047212.61359407
4Circadian entrainment_Homo sapiens_hsa047132.46694285
5Glutamatergic synapse_Homo sapiens_hsa047242.45798729
6Long-term potentiation_Homo sapiens_hsa047202.39927408
7Morphine addiction_Homo sapiens_hsa050322.35014267
8Olfactory transduction_Homo sapiens_hsa047402.32849037
9GABAergic synapse_Homo sapiens_hsa047272.28604215
10Amphetamine addiction_Homo sapiens_hsa050312.20927995
11Dopaminergic synapse_Homo sapiens_hsa047281.98466862
12Salivary secretion_Homo sapiens_hsa049701.97148716
13Serotonergic synapse_Homo sapiens_hsa047261.83288101
14Taste transduction_Homo sapiens_hsa047421.80529455
15Cholinergic synapse_Homo sapiens_hsa047251.75084923
16Long-term depression_Homo sapiens_hsa047301.74268069
17Renin secretion_Homo sapiens_hsa049241.73082446
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73034233
19Axon guidance_Homo sapiens_hsa043601.72959116
20Insulin secretion_Homo sapiens_hsa049111.72215895
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65071846
22Oxytocin signaling pathway_Homo sapiens_hsa049211.59626679
23Calcium signaling pathway_Homo sapiens_hsa040201.55894413
24Cocaine addiction_Homo sapiens_hsa050301.55111750
25Gastric acid secretion_Homo sapiens_hsa049711.54497496
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45089720
27GnRH signaling pathway_Homo sapiens_hsa049121.44984125
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44639473
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38340073
30ErbB signaling pathway_Homo sapiens_hsa040121.36528967
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33590998
32Collecting duct acid secretion_Homo sapiens_hsa049661.29647524
33Butanoate metabolism_Homo sapiens_hsa006501.29087156
34cAMP signaling pathway_Homo sapiens_hsa040241.26790346
35Gap junction_Homo sapiens_hsa045401.26546969
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20954554
37Selenocompound metabolism_Homo sapiens_hsa004501.19037939
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15479655
39Type II diabetes mellitus_Homo sapiens_hsa049301.14835800
40Estrogen signaling pathway_Homo sapiens_hsa049151.14811361
41Glioma_Homo sapiens_hsa052141.13951843
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09401585
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09108136
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.08615785
45Melanogenesis_Homo sapiens_hsa049161.08302153
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04876251
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03792246
48ECM-receptor interaction_Homo sapiens_hsa045121.03724455
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03246325
50Dilated cardiomyopathy_Homo sapiens_hsa054140.95226285
51Hippo signaling pathway_Homo sapiens_hsa043900.94696265
52ABC transporters_Homo sapiens_hsa020100.93614400
53MAPK signaling pathway_Homo sapiens_hsa040100.93003770
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92454606
55Choline metabolism in cancer_Homo sapiens_hsa052310.90981497
56Rap1 signaling pathway_Homo sapiens_hsa040150.87791018
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87326693
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87195585
59Wnt signaling pathway_Homo sapiens_hsa043100.86837893
60Ras signaling pathway_Homo sapiens_hsa040140.86231425
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.86029948
62Focal adhesion_Homo sapiens_hsa045100.84175555
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.83309280
64Vibrio cholerae infection_Homo sapiens_hsa051100.83208142
65Dorso-ventral axis formation_Homo sapiens_hsa043200.82284459
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81764736
67Nitrogen metabolism_Homo sapiens_hsa009100.80202396
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80031554
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79589033
70Phototransduction_Homo sapiens_hsa047440.79269426
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78620238
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78160175
73Linoleic acid metabolism_Homo sapiens_hsa005910.76670113
74Basal cell carcinoma_Homo sapiens_hsa052170.74500143
75TGF-beta signaling pathway_Homo sapiens_hsa043500.74429734
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.73987617
77Ether lipid metabolism_Homo sapiens_hsa005650.73779033
78Renal cell carcinoma_Homo sapiens_hsa052110.72603793
79Colorectal cancer_Homo sapiens_hsa052100.71957880
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67903475
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.66079321
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65973796
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65457019
84Endometrial cancer_Homo sapiens_hsa052130.65317350
85Tryptophan metabolism_Homo sapiens_hsa003800.63205469
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62964770
87Tight junction_Homo sapiens_hsa045300.62883307
88VEGF signaling pathway_Homo sapiens_hsa043700.61868537
89Circadian rhythm_Homo sapiens_hsa047100.61860528
90Oocyte meiosis_Homo sapiens_hsa041140.61855143
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60816173
92African trypanosomiasis_Homo sapiens_hsa051430.60392817
93Pancreatic secretion_Homo sapiens_hsa049720.60034615
94Lysine degradation_Homo sapiens_hsa003100.59388829
95Regulation of autophagy_Homo sapiens_hsa041400.58637384
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.57726191
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57720577
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57209606
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56310561
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53832005
101Cardiac muscle contraction_Homo sapiens_hsa042600.53739517
102Melanoma_Homo sapiens_hsa052180.53259168
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53254076
104Inositol phosphate metabolism_Homo sapiens_hsa005620.51852816
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51434122
106Protein digestion and absorption_Homo sapiens_hsa049740.51411485
107Thyroid hormone synthesis_Homo sapiens_hsa049180.49250089
108Glucagon signaling pathway_Homo sapiens_hsa049220.49212405
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.49070735
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48657705
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48641460
112Ovarian steroidogenesis_Homo sapiens_hsa049130.47918622
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46181599
114Hedgehog signaling pathway_Homo sapiens_hsa043400.46098811
115Non-small cell lung cancer_Homo sapiens_hsa052230.45720596
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45156398
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44476645
118Sphingolipid metabolism_Homo sapiens_hsa006000.44144865
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42843200
120Chemokine signaling pathway_Homo sapiens_hsa040620.42627452
121mTOR signaling pathway_Homo sapiens_hsa041500.41410714
122Adherens junction_Homo sapiens_hsa045200.40616133
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40335157
124Prion diseases_Homo sapiens_hsa050200.40223468
125Endocytosis_Homo sapiens_hsa041440.39758120
126Basal transcription factors_Homo sapiens_hsa030220.39720564
127Retinol metabolism_Homo sapiens_hsa008300.37933809
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37770213
129Platelet activation_Homo sapiens_hsa046110.37505422
130Pancreatic cancer_Homo sapiens_hsa052120.36255311
131Prolactin signaling pathway_Homo sapiens_hsa049170.35215157
132FoxO signaling pathway_Homo sapiens_hsa040680.35174026
133Histidine metabolism_Homo sapiens_hsa003400.34891416
134Proteoglycans in cancer_Homo sapiens_hsa052050.34777723
135Protein export_Homo sapiens_hsa030600.34431874
136Chemical carcinogenesis_Homo sapiens_hsa052040.33611240

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