ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	Golgi transport vesicle coating (GO:0048200)	4.39842470
2	COPI coating of Golgi vesicle (GO:0048205)	4.39842470
3	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.19519436
4	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	4.18916973
5	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.98480347
6	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.94799400
7	glutamate secretion (GO:0014047)	3.82167011
8	positive regulation of synapse maturation (GO:0090129)	3.80476122
9	regulation of synaptic vesicle exocytosis (GO:2000300)	3.78528800
10	synaptic vesicle maturation (GO:0016188)	3.74766602
11	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.73174798
12	layer formation in cerebral cortex (GO:0021819)	3.69694120
13	synaptic vesicle exocytosis (GO:0016079)	3.63903492
14	long term synaptic depression (GO:0060292)	3.63486744
15	protein retention in ER lumen (GO:0006621)	3.60698510
16	regulation of cholesterol biosynthetic process (GO:0045540)	3.54424356
17	regulation of ARF protein signal transduction (GO:0032012)	3.50476339
18	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.46710667
19	cell-cell junction maintenance (GO:0045217)	3.44902024
20	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.43796334
21	neuronal ion channel clustering (GO:0045161)	3.41164531
22	short-chain fatty acid metabolic process (GO:0046459)	3.40993238
23	atrioventricular valve morphogenesis (GO:0003181)	3.37422009
24	establishment of mitochondrion localization (GO:0051654)	3.33045878
25	dendritic spine organization (GO:0097061)	3.24233437
26	amyloid precursor protein catabolic process (GO:0042987)	3.22972212
27	regulation of cholesterol metabolic process (GO:0090181)	3.21340693
28	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.99982639
29	biotin metabolic process (GO:0006768)	2.99823243
30	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.97328117
31	mitochondrion transport along microtubule (GO:0047497)	2.97328117
32	regulation of synaptic vesicle transport (GO:1902803)	2.93239421
33	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.90401116
34	sodium ion export (GO:0071436)	2.89099372
35	negative regulation of cell size (GO:0045792)	2.86459075
36	cell junction maintenance (GO:0034331)	2.85202003
37	creatine metabolic process (GO:0006600)	2.84054015
38	synaptic vesicle endocytosis (GO:0048488)	2.83286777
39	positive regulation of protein sumoylation (GO:0033235)	2.80949428
40	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.80628012
41	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.80490421
42	neurotransmitter secretion (GO:0007269)	2.78131295
43	ethanol oxidation (GO:0006069)	2.74950052
44	histone H4 deacetylation (GO:0070933)	2.73818477
45	regulation of synapse maturation (GO:0090128)	2.73764041
46	regulation of neuronal synaptic plasticity (GO:0048168)	2.70470519
47	cellular component maintenance (GO:0043954)	2.69643501
48	4-hydroxyproline metabolic process (GO:0019471)	2.62412856
49	endothelial cell chemotaxis (GO:0035767)	2.58907746
50	phosphate ion transmembrane transport (GO:0035435)	2.55570668
51	growth hormone secretion (GO:0030252)	2.55200881
52	chaperone-mediated protein complex assembly (GO:0051131)	2.55020357
53	amyloid precursor protein metabolic process (GO:0042982)	2.54402802
54	purine nucleotide transport (GO:0015865)	2.53711913
55	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.53344908
56	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.53105113
57	cellular potassium ion homeostasis (GO:0030007)	2.52827755
58	regulation of synaptic plasticity (GO:0048167)	2.51789412
59	urea metabolic process (GO:0019627)	2.50621897
60	acetyl-CoA metabolic process (GO:0006084)	2.48125280
61	macroautophagy (GO:0016236)	2.47283759
62	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.47252293
63	amino acid import (GO:0043090)	2.46990599
64	dopamine receptor signaling pathway (GO:0007212)	2.45705779
65	response to dietary excess (GO:0002021)	2.45370885
66	positive regulation of mitochondrial fission (GO:0090141)	2.44913068
67	cell migration in hindbrain (GO:0021535)	2.44585322
68	cellular response to gonadotropin stimulus (GO:0071371)	2.44417026
69	nitrogen cycle metabolic process (GO:0071941)	2.44405424
70	N-glycan processing (GO:0006491)	2.44368107
71	skeletal muscle organ development (GO:0060538)	2.42735264
72	respiratory system process (GO:0003016)	2.42062663
73	urea cycle (GO:0000050)	2.39545228
74	peptidyl-glutamic acid carboxylation (GO:0017187)	2.38654868
75	protein carboxylation (GO:0018214)	2.38654868
76	protein insertion into membrane (GO:0051205)	2.37180849
77	vesicle transport along microtubule (GO:0047496)	2.36606468
78	regulation of ARF GTPase activity (GO:0032312)	2.35241150
79	receptor recycling (GO:0001881)	2.35136086
80	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.34546521
81	peroxisome fission (GO:0016559)	2.33851067
82	glycolytic process (GO:0006096)	2.33678910
83	regulation of actin nucleation (GO:0051125)	2.33314941
84	diaphragm development (GO:0060539)	2.33236181
85	regulation of NFAT protein import into nucleus (GO:0051532)	2.32942596
86	regulation of early endosome to late endosome transport (GO:2000641)	2.32348239
87	phosphate ion transport (GO:0006817)	2.32218778
88	autophagic vacuole assembly (GO:0000045)	2.31237494
89	L-phenylalanine metabolic process (GO:0006558)	2.29098467
90	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.29098467
91	protein localization to endosome (GO:0036010)	2.28373971
92	positive regulation of male gonad development (GO:2000020)	2.28332509
93	activation of MAPKKK activity (GO:0000185)	2.27805564
94	cellular response to catecholamine stimulus (GO:0071870)	2.26223900
95	cellular response to monoamine stimulus (GO:0071868)	2.26223900
96	cerebellar granule cell differentiation (GO:0021707)	2.24520569
97	gluconeogenesis (GO:0006094)	2.23617161
98	fructose metabolic process (GO:0006000)	2.21893843
99	adenine nucleotide transport (GO:0051503)	2.21800772
100	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.20983839

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.44704841
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.20182272
3	LXR_22292898_ChIP-Seq_THP-1_Human	2.81316661
4	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.63205419
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.58862663
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.38769275
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.31219091
8	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.30341384
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.28807362
10	SMC4_20622854_ChIP-Seq_HELA_Human	2.06942575
11	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.05508166
12	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.03618877
13	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.99272522
14	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.98086089
15	KDM2B_26808549_Chip-Seq_K562_Human	1.97985517
16	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.94861453
17	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.93927601
18	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.87142328
19	P68_20966046_ChIP-Seq_HELA_Human	1.86505905
20	RACK7_27058665_Chip-Seq_MCF-7_Human	1.85006313
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.83875615
22	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.83282779
23	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.82213974
24	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.81685749
25	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.81215850
26	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.77376150
27	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.74853238
28	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68504982
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.64059593
30	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.62655371
31	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.60552001
32	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.60283167
33	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.59219118
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.57972739
35	KDM2B_26808549_Chip-Seq_DND41_Human	1.56844170
36	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.55524087
37	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.55510059
38	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.52479667
39	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.49997084
40	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.49340953
41	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.47941651
42	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.47413181
43	CREB1_26743006_Chip-Seq_LNCaP_Human	1.45764280
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.44182964
45	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.42763170
46	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.40408078
47	VDR_21846776_ChIP-Seq_THP-1_Human	1.40039204
48	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.38225016
49	CLOCK_20551151_ChIP-Seq_293T_Human	1.37722969
50	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.33931711
51	BCOR_27268052_Chip-Seq_Bcells_Human	1.33199018
52	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.32130265
53	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.31468654
54	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29616035
55	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28155841
56	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.27718007
57	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.26368183
58	DROSHA_22980978_ChIP-Seq_HELA_Human	1.25913389
59	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.24282868
60	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.23085601
61	TP53_22127205_ChIP-Seq_IMR90_Human	1.22365909
62	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21631634
63	TCF7_22412390_ChIP-Seq_EML_Mouse	1.20488586
64	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.20270014
65	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.19796631
66	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19300051
67	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.17790523
68	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17611878
69	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.17406141
70	BCL6_27268052_Chip-Seq_Bcells_Human	1.15726774
71	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.15612006
72	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.13949354
73	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.13927322
74	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.11657637
75	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.11265278
76	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.10711883
77	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.10320878
78	TP63_22573176_ChIP-Seq_HFKS_Human	1.08655728
79	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07705659
80	PHF8_20622854_ChIP-Seq_HELA_Human	1.07066050
81	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.05986397
82	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.05555477
83	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.05523878
84	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.05416554
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.03524983
86	OCT4_19829295_ChIP-Seq_ESCs_Human	1.03294913
87	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.99850005
88	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.99781684
89	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.99190311
90	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.97980681
91	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.96890268
92	MITF_21258399_ChIP-Seq_MELANOMA_Human	0.96518835
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.96047844
94	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.95739583
95	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.95653426
96	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.95307850
97	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.94950613
98	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.93615056
99	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.93083214
100	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.93083214

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.03740576
2	MP0002822_catalepsy	3.36999733
3	MP0004270_analgesia	3.22061796
4	MP0005451_abnormal_body_composition	2.93976517
5	MP0005058_abnormal_lysosome_morphology	2.91706769
6	MP0005423_abnormal_somatic_nervous	2.86691211
7	MP0010234_abnormal_vibrissa_follicle	2.66582679
8	MP0002909_abnormal_adrenal_gland	2.61866546
9	MP0009840_abnormal_foam_cell	2.52999483
10	MP0003123_paternal_imprinting	2.50632397
11	MP0003329_amyloid_beta_deposits	2.42988129
12	MP0000751_myopathy	2.38125362
13	MP0003879_abnormal_hair_cell	2.33469693
14	MP0001984_abnormal_olfaction	2.24328030
15	MP0002638_abnormal_pupillary_reflex	2.18342267
16	MP0009780_abnormal_chondrocyte_physiolo	2.12123457
17	MP0002139_abnormal_hepatobiliary_system	2.11525763
18	MP0001661_extended_life_span	2.08898575
19	MP0003880_abnormal_central_pattern	2.06247410
20	MP0003635_abnormal_synaptic_transmissio	2.04118928
21	MP0005499_abnormal_olfactory_system	1.86559251
22	MP0005394_taste/olfaction_phenotype	1.86559251
23	MP0006276_abnormal_autonomic_nervous	1.66743511
24	MP0002063_abnormal_learning/memory/cond	1.64621674
25	MP0002734_abnormal_mechanical_nocicepti	1.60136184
26	MP0003172_abnormal_lysosome_physiology	1.59155420
27	MP0003122_maternal_imprinting	1.57897513
28	MP0005365_abnormal_bile_salt	1.57126348
29	MP0000537_abnormal_urethra_morphology	1.56950299
30	MP0004858_abnormal_nervous_system	1.56242157
31	MP0008260_abnormal_autophagy	1.53043667
32	MP0003787_abnormal_imprinting	1.50968651
33	MP0002064_seizures	1.48036305
34	MP0000678_abnormal_parathyroid_gland	1.44912774
35	MP0003191_abnormal_cellular_cholesterol	1.39303295
36	MP0002653_abnormal_ependyma_morphology	1.35746338
37	MP0010386_abnormal_urinary_bladder	1.32834583
38	MP0000604_amyloidosis	1.28369058
39	MP0000778_abnormal_nervous_system	1.28079386
40	MP0002572_abnormal_emotion/affect_behav	1.27166411
41	MP0005645_abnormal_hypothalamus_physiol	1.25347136
42	MP0002735_abnormal_chemical_nociception	1.23339144
43	MP0001502_abnormal_circadian_rhythm	1.23198891
44	MP0008789_abnormal_olfactory_epithelium	1.20869142
45	MP0000003_abnormal_adipose_tissue	1.20252313
46	MP0003634_abnormal_glial_cell	1.18688580
47	MP0005360_urolithiasis	1.17799968
48	MP0003705_abnormal_hypodermis_morpholog	1.17398919
49	MP0002272_abnormal_nervous_system	1.16677562
50	MP0003690_abnormal_glial_cell	1.13855158
51	MP0000639_abnormal_adrenal_gland	1.13420350
52	MP0009745_abnormal_behavioral_response	1.09327264
53	MP0000462_abnormal_digestive_system	1.06552372
54	MP0004811_abnormal_neuron_physiology	1.04745480
55	MP0000681_abnormal_thyroid_gland	1.04686615
56	MP0000538_abnormal_urinary_bladder	1.01713238
57	MP0002132_abnormal_respiratory_system	0.98713437
58	MP0005409_darkened_coat_color	0.98057444
59	MP0001764_abnormal_homeostasis	0.97455521
60	MP0008874_decreased_physiological_sensi	0.97064077
61	MP0000747_muscle_weakness	0.96656808
62	MP0002557_abnormal_social/conspecific_i	0.96290910
63	MP0000920_abnormal_myelination	0.94806367
64	MP0008995_early_reproductive_senescence	0.94610426
65	MP0005257_abnormal_intraocular_pressure	0.94341694
66	MP0000759_abnormal_skeletal_muscle	0.93599283
67	MP0000013_abnormal_adipose_tissue	0.92770261
68	MP0002249_abnormal_larynx_morphology	0.92207562
69	MP0002295_abnormal_pulmonary_circulatio	0.91814509
70	MP0003315_abnormal_perineum_morphology	0.89752057
71	MP0010329_abnormal_lipoprotein_level	0.89474209
72	MP0001348_abnormal_lacrimal_gland	0.87689060
73	MP0002066_abnormal_motor_capabilities/c	0.86898305
74	MP0008875_abnormal_xenobiotic_pharmacok	0.85453013
75	MP0009384_cardiac_valve_regurgitation	0.85377877
76	MP0002089_abnormal_postnatal_growth/wei	0.84531203
77	MP0005535_abnormal_body_temperature	0.83745895
78	MP0002882_abnormal_neuron_morphology	0.82816750
79	MP0004145_abnormal_muscle_electrophysio	0.82129672
80	MP0004510_myositis	0.81695577
81	MP0001970_abnormal_pain_threshold	0.81611707
82	MP0001756_abnormal_urination	0.80031546
83	MP0000955_abnormal_spinal_cord	0.78766636
84	MP0002118_abnormal_lipid_homeostasis	0.78283383
85	MP0001529_abnormal_vocalization	0.76319693
86	MP0003942_abnormal_urinary_system	0.75808058
87	MP0001968_abnormal_touch/_nociception	0.75714545
88	MP0004233_abnormal_muscle_weight	0.72536459
89	MP0002896_abnormal_bone_mineralization	0.72347460
90	MP0001664_abnormal_digestion	0.68963304
91	MP0001905_abnormal_dopamine_level	0.68864354
92	MP0002733_abnormal_thermal_nociception	0.68779654
93	MP0004087_abnormal_muscle_fiber	0.67386315
94	MP0006036_abnormal_mitochondrial_physio	0.67308203
95	MP0003633_abnormal_nervous_system	0.67216288
96	MP0001849_ear_inflammation	0.66386774
97	MP0001727_abnormal_embryo_implantation	0.66086857
98	MP0008569_lethality_at_weaning	0.63705102
99	MP0002876_abnormal_thyroid_physiology	0.63108834
100	MP0002152_abnormal_brain_morphology	0.62881567

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ankle clonus (HP:0011448)	3.89465853
2	Hand muscle atrophy (HP:0009130)	3.74095232
3	Distal upper limb amyotrophy (HP:0007149)	3.66990817
4	Upper limb amyotrophy (HP:0009129)	3.66990817
5	Obstructive sleep apnea (HP:0002870)	3.62251189
6	Testicular neoplasm (HP:0010788)	3.50456254
7	Stridor (HP:0010307)	3.31251613
8	Achilles tendon contracture (HP:0001771)	3.31054808
9	Abnormality of the Achilles tendon (HP:0005109)	3.18752089
10	Bronchomalacia (HP:0002780)	3.14932484
11	Abnormality of the lower motor neuron (HP:0002366)	3.06290571
12	Myokymia (HP:0002411)	3.03967009
13	Supranuclear gaze palsy (HP:0000605)	2.87502544
14	Neurofibrillary tangles (HP:0002185)	2.85315527
15	Cerebral inclusion bodies (HP:0100314)	2.65000192
16	Vertebral arch anomaly (HP:0008438)	2.47751945
17	Shoulder girdle muscle weakness (HP:0003547)	2.46245918
18	Spastic gait (HP:0002064)	2.42176240
19	Neuronal loss in central nervous system (HP:0002529)	2.38536350
20	Urinary urgency (HP:0000012)	2.38159015
21	Turricephaly (HP:0000262)	2.37990850
22	Depression (HP:0000716)	2.35333473
23	Growth hormone excess (HP:0000845)	2.35247359
24	Sleep apnea (HP:0010535)	2.32111202
25	Mesangial abnormality (HP:0001966)	2.31490317
26	Hypercortisolism (HP:0001578)	2.30969424
27	Thoracic kyphosis (HP:0002942)	2.29422696
28	Exercise-induced myalgia (HP:0003738)	2.29214276
29	Hyperacusis (HP:0010780)	2.23998474
30	Intention tremor (HP:0002080)	2.21828350
31	Long palpebral fissure (HP:0000637)	2.21450832
32	Gonadal dysgenesis (HP:0000133)	2.06794343
33	Vertebral compression fractures (HP:0002953)	2.06537777
34	Anomalous pulmonary venous return (HP:0010772)	2.05760588
35	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.03597386
36	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.02971233
37	Amblyopia (HP:0000646)	2.00878025
38	Retinal atrophy (HP:0001105)	2.00384018
39	Complement deficiency (HP:0004431)	2.00260030
40	Ragged-red muscle fibers (HP:0003200)	2.00115040
41	Abnormality of the thoracic spine (HP:0100711)	1.99964212
42	Peripheral hypomyelination (HP:0007182)	1.99052582
43	Myopathic facies (HP:0002058)	1.98155328
44	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.98107154
45	Hyperthyroidism (HP:0000836)	1.96653325
46	Germ cell neoplasia (HP:0100728)	1.96197749
47	Deep palmar crease (HP:0006191)	1.94939411
48	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.93991064
49	Hyperparathyroidism (HP:0000843)	1.93601555
50	Apathy (HP:0000741)	1.93545058
51	Diminished motivation (HP:0000745)	1.92498027
52	Atelectasis (HP:0100750)	1.91979373
53	Papilledema (HP:0001085)	1.91814384
54	Pointed chin (HP:0000307)	1.91792216
55	Hypoplastic left heart (HP:0004383)	1.89451160
56	Deep venous thrombosis (HP:0002625)	1.89361007
57	Flat acetabular roof (HP:0003180)	1.88520812
58	Testicular atrophy (HP:0000029)	1.87722491
59	Abnormality of complement system (HP:0005339)	1.87227868
60	Dysmetria (HP:0001310)	1.87028507
61	Insomnia (HP:0100785)	1.85525994
62	Lower limb muscle weakness (HP:0007340)	1.85356128
63	Limb-girdle muscle weakness (HP:0003325)	1.83994018
64	Abnormality of the pulmonary veins (HP:0011718)	1.81616676
65	Abnormality of the vocal cords (HP:0008777)	1.75923453
66	Ulnar bowing (HP:0003031)	1.75327109
67	Abnormal connection of the cardiac segments (HP:0011545)	1.73526341
68	Abnormal ventriculo-arterial connection (HP:0011563)	1.73526341
69	Transposition of the great arteries (HP:0001669)	1.73526341
70	Cervical subluxation (HP:0003308)	1.73180708
71	Spinal canal stenosis (HP:0003416)	1.73116391
72	Back pain (HP:0003418)	1.73010664
73	Difficulty climbing stairs (HP:0003551)	1.70500886
74	Akinesia (HP:0002304)	1.68010798
75	Abnormal tarsal ossification (HP:0008369)	1.67847294
76	Abnormal gallbladder physiology (HP:0012438)	1.67508853
77	Cholecystitis (HP:0001082)	1.67508853
78	Systemic lupus erythematosus (HP:0002725)	1.66037073
79	Clonus (HP:0002169)	1.65975348
80	Diaphragmatic weakness (HP:0009113)	1.65305145
81	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.64800869
82	Abnormality of polysaccharide metabolism (HP:0011012)	1.64800869
83	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.64800869
84	Microvesicular hepatic steatosis (HP:0001414)	1.64688112
85	Spinal rigidity (HP:0003306)	1.63869569
86	Hyperglycinemia (HP:0002154)	1.63846079
87	Gout (HP:0001997)	1.63731508
88	Scanning speech (HP:0002168)	1.63096844
89	Abnormality of the musculature of the hand (HP:0001421)	1.62509738
90	Bulbar palsy (HP:0001283)	1.62495965
91	Increased connective tissue (HP:0009025)	1.59658610
92	Dementia (HP:0000726)	1.59501959
93	Abnormality of the motor neurons (HP:0002450)	1.59157597
94	Abnormal neuron morphology (HP:0012757)	1.59157597
95	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.58995460
96	Thin bony cortex (HP:0002753)	1.58001493
97	Neonatal onset (HP:0003623)	1.57972938
98	Urinary glycosaminoglycan excretion (HP:0003541)	1.57939605
99	Mucopolysacchariduria (HP:0008155)	1.57939605
100	EEG with generalized epileptiform discharges (HP:0011198)	1.57256483

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	2.77490269
2	PRPF4B	2.73276974
3	RIPK1	2.26931281
4	ARAF	2.23162098
5	ERN1	2.18702464
6	TESK1	2.11138542
7	CAMK1D	2.01288411
8	NTRK1	1.96280151
9	MARK2	1.95715210
10	EPHA4	1.89318015
11	CDK19	1.84205998
12	MAP3K9	1.74791607
13	ICK	1.74216712
14	MAP3K11	1.70654028
15	PRKD2	1.66670242
16	PRKD3	1.63585950
17	DYRK1B	1.57001761
18	MARK1	1.55429942
19	CAMK1G	1.54460035
20	CAMKK1	1.54308431
21	DAPK2	1.54103215
22	IRAK2	1.51646680
23	CDK12	1.48940662
24	TNK2	1.46887299
25	PDK2	1.41581389
26	DDR2	1.39021824
27	PAK6	1.33271235
28	EPHA2	1.33176300
29	SIK1	1.26933403
30	PIM2	1.26850321
31	KSR2	1.23789166
32	STK38	1.22118077
33	MAP3K7	1.20509983
34	TAOK1	1.16854999
35	EEF2K	1.15797506
36	NTRK3	1.14653569
37	LMTK2	1.14636692
38	MAP2K7	1.11403089
39	UHMK1	1.06675229
40	PTK2	1.04444561
41	NTRK2	1.03988610
42	IRAK3	1.03039067
43	PDPK1	1.01613820
44	PHKG2	1.00838312
45	PHKG1	1.00838312
46	LIMK1	0.99818769
47	PDGFRA	0.98178059
48	TAOK2	0.98066101
49	PKN2	0.96388702
50	CDK5	0.94901220
51	PRKCI	0.88329201
52	BRAF	0.85774962
53	MAP3K1	0.82206829
54	SIK2	0.81483746
55	LATS2	0.80086133
56	STK38L	0.79814177
57	CAMK1	0.79678838
58	MTOR	0.79237125
59	RPS6KA2	0.79050590
60	MAP3K2	0.78645478
61	TYRO3	0.77601360
62	FGFR4	0.73505806
63	PAK3	0.72875485
64	AURKA	0.72349510
65	PRKAA1	0.72040058
66	PRKCZ	0.71860295
67	SGK223	0.71296272
68	SGK494	0.71296272
69	EPHB1	0.70896839
70	CDK11A	0.70068662
71	MST1R	0.69491698
72	MAP3K13	0.69408285
73	CASK	0.68800439
74	AKT2	0.68489793
75	PRKD1	0.68090468
76	CAMK4	0.67304133
77	MAP2K4	0.67242116
78	PINK1	0.66595941
79	MINK1	0.65895553
80	DAPK1	0.65640521
81	CDK15	0.64147068
82	PDK1	0.63992607
83	MET	0.63900787
84	SMG1	0.63015012
85	FGFR2	0.60387885
86	CAMK2G	0.58226814
87	CDK18	0.56988953
88	SGK3	0.54625229
89	MAPK12	0.54284970
90	CDK14	0.54256835
91	DYRK1A	0.54187062
92	CDC42BPA	0.54048904
93	CSNK1G3	0.52873265
94	CAMK2B	0.52498316
95	PRKCH	0.51732091
96	TESK2	0.50913229
97	MATK	0.49655184
98	RAF1	0.49497674
99	PRKAA2	0.48722084
100	MAPK10	0.46853062

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.75666312
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.56476623
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.32891409
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.19356025
5	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.88351157
6	Phenylalanine metabolism_Homo sapiens_hsa00360	1.82221393
7	Vibrio cholerae infection_Homo sapiens_hsa05110	1.76158006
8	Arginine biosynthesis_Homo sapiens_hsa00220	1.72857879
9	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.72249292
10	Other glycan degradation_Homo sapiens_hsa00511	1.71855141
11	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.69326928
12	Sulfur relay system_Homo sapiens_hsa04122	1.68921980
13	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.62314295
14	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.59298352
15	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.49717563
16	Prion diseases_Homo sapiens_hsa05020	1.49113989
17	Carbon metabolism_Homo sapiens_hsa01200	1.47012535
18	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.46434661
19	Arginine and proline metabolism_Homo sapiens_hsa00330	1.45905514
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.45639415
21	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.44766202
22	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.42982873
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.35423527
24	Insulin secretion_Homo sapiens_hsa04911	1.30642350
25	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.26816316
26	Bile secretion_Homo sapiens_hsa04976	1.26314755
27	Fatty acid degradation_Homo sapiens_hsa00071	1.23364285
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22136785
29	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.19168617
30	Fatty acid metabolism_Homo sapiens_hsa01212	1.16910259
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13024099
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09361299
33	AMPK signaling pathway_Homo sapiens_hsa04152	1.09191133
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.07347520
35	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.07076834
36	Insulin signaling pathway_Homo sapiens_hsa04910	1.06539320
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.06026472
38	Pentose phosphate pathway_Homo sapiens_hsa00030	1.05043575
39	Long-term potentiation_Homo sapiens_hsa04720	0.99133455
40	Fatty acid elongation_Homo sapiens_hsa00062	0.98756933
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97297609
42	Butanoate metabolism_Homo sapiens_hsa00650	0.94475244
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93958952
44	Complement and coagulation cascades_Homo sapiens_hsa04610	0.93660196
45	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.93288262
46	Histidine metabolism_Homo sapiens_hsa00340	0.92782980
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.91112503
48	Galactose metabolism_Homo sapiens_hsa00052	0.90476008
49	GABAergic synapse_Homo sapiens_hsa04727	0.90072105
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89175433
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.88874692
52	Nicotine addiction_Homo sapiens_hsa05033	0.84819698
53	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.83673545
54	Lysine degradation_Homo sapiens_hsa00310	0.83383389
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82563417
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82083471
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80802878
58	Cocaine addiction_Homo sapiens_hsa05030	0.80608331
59	Glucagon signaling pathway_Homo sapiens_hsa04922	0.80213195
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78386243
61	Amphetamine addiction_Homo sapiens_hsa05031	0.77962907
62	Notch signaling pathway_Homo sapiens_hsa04330	0.77708866
63	mTOR signaling pathway_Homo sapiens_hsa04150	0.76548100
64	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.74413619
65	Peroxisome_Homo sapiens_hsa04146	0.73980009
66	Endocytosis_Homo sapiens_hsa04144	0.73041325
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71844306
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70474295
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.69057842
70	Gap junction_Homo sapiens_hsa04540	0.67521494
71	ErbB signaling pathway_Homo sapiens_hsa04012	0.65717435
72	Cholinergic synapse_Homo sapiens_hsa04725	0.65622724
73	VEGF signaling pathway_Homo sapiens_hsa04370	0.64984676
74	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.64878250
75	GnRH signaling pathway_Homo sapiens_hsa04912	0.64422354
76	Folate biosynthesis_Homo sapiens_hsa00790	0.63834693
77	Endometrial cancer_Homo sapiens_hsa05213	0.62817453
78	Lysosome_Homo sapiens_hsa04142	0.60765739
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60642011
80	Circadian entrainment_Homo sapiens_hsa04713	0.59694568
81	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.59570534
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.58784905
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58138028
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56380724
85	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56215141
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55159711
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55148750
88	Insulin resistance_Homo sapiens_hsa04931	0.53462930
89	Axon guidance_Homo sapiens_hsa04360	0.52998489
90	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.51682290
91	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.51582684
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51397785
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.50883580
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49363667
95	Morphine addiction_Homo sapiens_hsa05032	0.48619129
96	Propanoate metabolism_Homo sapiens_hsa00640	0.48108300
97	Melanogenesis_Homo sapiens_hsa04916	0.48078726
98	Tight junction_Homo sapiens_hsa04530	0.46724605
99	Glioma_Homo sapiens_hsa05214	0.45529413
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44816089

NAXD

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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