NAXE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitochondrial translation (GO:0070129)5.54387183
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.15699292
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71269388
4GDP-mannose metabolic process (GO:0019673)4.69565658
5ribosomal small subunit biogenesis (GO:0042274)4.44748937
6proteasome assembly (GO:0043248)4.26367176
7rRNA modification (GO:0000154)4.22717449
8protein maturation by protein folding (GO:0022417)4.14629418
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14517629
10ATP synthesis coupled proton transport (GO:0015986)4.14517629
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10971824
12chaperone-mediated protein transport (GO:0072321)4.10450577
13oxidative phosphorylation (GO:0006119)4.03647238
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01713270
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.86833860
16negative regulation of ligase activity (GO:0051352)3.86833860
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81668886
18respiratory electron transport chain (GO:0022904)3.78731055
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76439987
20electron transport chain (GO:0022900)3.71817867
21pseudouridine synthesis (GO:0001522)3.71797238
22regulation of cellular amino acid metabolic process (GO:0006521)3.69124338
23telomere maintenance via semi-conservative replication (GO:0032201)3.69086845
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68446401
25guanosine-containing compound biosynthetic process (GO:1901070)3.67862265
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67603602
27protein targeting to mitochondrion (GO:0006626)3.67593202
28DNA strand elongation involved in DNA replication (GO:0006271)3.63371010
29nucleobase-containing small molecule interconversion (GO:0015949)3.57970235
30DNA strand elongation (GO:0022616)3.50781334
31L-serine metabolic process (GO:0006563)3.50649478
32protein complex biogenesis (GO:0070271)3.48688368
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.45906239
34cullin deneddylation (GO:0010388)3.43436760
35establishment of protein localization to mitochondrion (GO:0072655)3.41319090
36mitochondrial respiratory chain complex assembly (GO:0033108)3.39558708
37respiratory chain complex IV assembly (GO:0008535)3.38965047
38pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.38739961
39protein deneddylation (GO:0000338)3.36455420
40UTP biosynthetic process (GO:0006228)3.35787704
41termination of RNA polymerase III transcription (GO:0006386)3.35536730
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.35536730
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35478998
44metallo-sulfur cluster assembly (GO:0031163)3.35245633
45iron-sulfur cluster assembly (GO:0016226)3.35245633
46rRNA methylation (GO:0031167)3.33914438
47GTP biosynthetic process (GO:0006183)3.33727550
48cytochrome complex assembly (GO:0017004)3.33396774
49base-excision repair, AP site formation (GO:0006285)3.33007867
50ribonucleoprotein complex biogenesis (GO:0022613)3.32486212
51ribosomal large subunit biogenesis (GO:0042273)3.32418825
52pyrimidine nucleotide catabolic process (GO:0006244)3.31715717
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31442290
54regulation of translational fidelity (GO:0006450)3.31393608
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31318965
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26990734
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26990734
58pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.26252159
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25802733
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25802733
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25802733
62cellular component biogenesis (GO:0044085)3.25061678
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23928303
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.23928303
65protein localization to mitochondrion (GO:0070585)3.23127428
66DNA replication checkpoint (GO:0000076)3.20989626
67positive regulation of ligase activity (GO:0051351)3.20600806
68proline biosynthetic process (GO:0006561)3.19825320
69pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17889726
70CTP metabolic process (GO:0046036)3.15382678
71CTP biosynthetic process (GO:0006241)3.15382678
72signal transduction involved in cell cycle checkpoint (GO:0072395)3.14933343
73peptidyl-histidine modification (GO:0018202)3.09963243
74formation of translation preinitiation complex (GO:0001731)3.08985174
75regulation of ubiquitin-protein transferase activity (GO:0051438)3.08008645
76viral transcription (GO:0019083)3.07574980
77ribosomal small subunit assembly (GO:0000028)3.06529631
78nucleobase biosynthetic process (GO:0046112)3.06472730
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05342090
80translation (GO:0006412)3.05174672
81purine nucleobase biosynthetic process (GO:0009113)3.05149365
82ribosome biogenesis (GO:0042254)3.02637535
83UTP metabolic process (GO:0046051)3.01207774
84nuclear envelope reassembly (GO:0031468)2.99965413
85mitotic nuclear envelope reassembly (GO:0007084)2.99965413
86nucleoside salvage (GO:0043174)2.99849988
87deoxyribose phosphate biosynthetic process (GO:0046385)2.98946958
882-deoxyribonucleotide biosynthetic process (GO:0009265)2.98946958
89cotranslational protein targeting to membrane (GO:0006613)2.98270082
90folic acid metabolic process (GO:0046655)2.98227420
91regulation of ligase activity (GO:0051340)2.96638890
92deoxyribonucleotide catabolic process (GO:0009264)2.96436353
93protein targeting to ER (GO:0045047)2.95944700
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93757775
95mitochondrial respiratory chain complex I assembly (GO:0032981)2.93757775
96NADH dehydrogenase complex assembly (GO:0010257)2.93757775
97pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.93351776
98L-phenylalanine metabolic process (GO:0006558)2.92059541
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92059541
100pteridine-containing compound biosynthetic process (GO:0042559)2.91927293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61169978
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58203046
3E2F7_22180533_ChIP-Seq_HELA_Human3.53619314
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.53321395
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36704933
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29822596
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95546613
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92453683
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.85927506
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.74389887
11XRN2_22483619_ChIP-Seq_HELA_Human2.69642181
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63036889
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61917785
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49492877
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49425245
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47163689
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.32954148
18DCP1A_22483619_ChIP-Seq_HELA_Human2.29082805
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21965057
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20617855
21GABP_19822575_ChIP-Seq_HepG2_Human2.17417471
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12439576
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11069621
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07326294
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03940948
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00323537
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.89781427
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.89561027
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.88884121
30ZNF263_19887448_ChIP-Seq_K562_Human1.87577045
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87473595
32TTF2_22483619_ChIP-Seq_HELA_Human1.81226856
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81185854
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79526558
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78942722
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68350292
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64929664
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63644005
39FOXP3_21729870_ChIP-Seq_TREG_Human1.62859278
40KDM5A_27292631_Chip-Seq_BREAST_Human1.62456868
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.62445336
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60141575
43VDR_23849224_ChIP-Seq_CD4+_Human1.57349540
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.56423837
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54938184
46VDR_21846776_ChIP-Seq_THP-1_Human1.51225769
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.50602393
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49160893
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48141934
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47232851
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47005400
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46980004
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39925626
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39398815
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37117786
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33837264
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33794290
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33009651
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.31544585
60RACK7_27058665_Chip-Seq_MCF-7_Human1.31182872
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30623518
62LXR_22292898_ChIP-Seq_THP-1_Human1.30170229
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29591048
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29554245
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28273859
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26282582
67P68_20966046_ChIP-Seq_HELA_Human1.25650535
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24888825
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24649444
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22224432
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20480879
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19559223
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18946323
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18923641
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18882945
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.17556306
77TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16868308
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16532108
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16008857
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11989610
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10108131
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09471321
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08761984
84AR_21909140_ChIP-Seq_LNCAP_Human1.06501220
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06097675
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.05349544
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05259651
88TFEB_21752829_ChIP-Seq_HELA_Human1.04881612
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04646965
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03076658
91CIITA_25753668_ChIP-Seq_RAJI_Human1.03034521
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02386848
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02178341
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01919909
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.97917864
96ATF3_27146783_Chip-Seq_COLON_Human0.96730665
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.96355256
98BCL6_27268052_Chip-Seq_Bcells_Human0.96088718
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95288276
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94407536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.21576268
2MP0003806_abnormal_nucleotide_metabolis3.88221513
3MP0003111_abnormal_nucleus_morphology3.44954140
4MP0004957_abnormal_blastocyst_morpholog3.34271896
5MP0010094_abnormal_chromosome_stability3.23623927
6MP0005171_absent_coat_pigmentation3.10474610
7MP0003136_yellow_coat_color3.08287786
8MP0008058_abnormal_DNA_repair2.95842337
9MP0008932_abnormal_embryonic_tissue2.86653159
10MP0006036_abnormal_mitochondrial_physio2.85712858
11MP0003186_abnormal_redox_activity2.82106147
12MP0003077_abnormal_cell_cycle2.76330210
13MP0005058_abnormal_lysosome_morphology2.42739925
14MP0008007_abnormal_cellular_replicative2.38160078
15MP0003786_premature_aging2.31263372
16MP0010030_abnormal_orbit_morphology2.30660111
17MP0001661_extended_life_span2.27503684
18MP0005451_abnormal_body_composition2.24539134
19MP0005670_abnormal_white_adipose1.94660535
20MP0000372_irregular_coat_pigmentation1.92922031
21MP0006035_abnormal_mitochondrial_morpho1.90668614
22MP0000358_abnormal_cell_content/1.80190712
23MP0004233_abnormal_muscle_weight1.75667329
24MP0005501_abnormal_skin_physiology1.69452170
25MP0003123_paternal_imprinting1.66599111
26MP0005408_hypopigmentation1.64909914
27MP0005330_cardiomyopathy1.59742523
28MP0005332_abnormal_amino_acid1.53170983
29MP0000678_abnormal_parathyroid_gland1.51435110
30MP0010234_abnormal_vibrissa_follicle1.49118029
31MP0005174_abnormal_tail_pigmentation1.49107185
32MP0008875_abnormal_xenobiotic_pharmacok1.44661696
33MP0001764_abnormal_homeostasis1.40576632
34MP0001730_embryonic_growth_arrest1.38193193
35MP0001346_abnormal_lacrimal_gland1.38114759
36MP0003718_maternal_effect1.37250213
37MP0002163_abnormal_gland_morphology1.28462182
38MP0000350_abnormal_cell_proliferation1.28183112
39MP0000537_abnormal_urethra_morphology1.27992603
40MP0003315_abnormal_perineum_morphology1.26194183
41MP0002234_abnormal_pharynx_morphology1.23581268
42MP0000003_abnormal_adipose_tissue1.17878601
43MP0002796_impaired_skin_barrier1.16974749
44MP0001905_abnormal_dopamine_level1.12130471
45MP0002160_abnormal_reproductive_system1.12126951
46MP0009379_abnormal_foot_pigmentation1.11812610
47MP0004381_abnormal_hair_follicle1.10365432
48MP0002938_white_spotting1.09286709
49MP0009697_abnormal_copulation1.08973245
50MP0001881_abnormal_mammary_gland1.08663210
51MP0000313_abnormal_cell_death1.05058572
52MP0000750_abnormal_muscle_regeneration1.02960317
53MP0002080_prenatal_lethality1.01874721
54MP0002877_abnormal_melanocyte_morpholog1.01777650
55MP0005075_abnormal_melanosome_morpholog0.99922021
56MP0010307_abnormal_tumor_latency0.98265995
57MP0002837_dystrophic_cardiac_calcinosis0.96942876
58MP0001188_hyperpigmentation0.93274963
59MP0005584_abnormal_enzyme/coenzyme_acti0.92733102
60MP0000538_abnormal_urinary_bladder0.91944879
61MP0005379_endocrine/exocrine_gland_phen0.91585217
62MP0001986_abnormal_taste_sensitivity0.90365075
63MP0002019_abnormal_tumor_incidence0.89932848
64MP0000015_abnormal_ear_pigmentation0.87882984
65MP0001697_abnormal_embryo_size0.86394038
66MP0002736_abnormal_nociception_after0.85480727
67MP0004185_abnormal_adipocyte_glucose0.85277652
68MP0005083_abnormal_biliary_tract0.84140214
69MP0009840_abnormal_foam_cell0.83869326
70MP0000747_muscle_weakness0.82714293
71MP0001756_abnormal_urination0.82220178
72MP0002249_abnormal_larynx_morphology0.78155608
73MP0005220_abnormal_exocrine_pancreas0.77179912
74MP0010771_integument_phenotype0.75458375
75MP0001727_abnormal_embryo_implantation0.74376937
76MP0001186_pigmentation_phenotype0.74226057
77MP0001672_abnormal_embryogenesis/_devel0.72717290
78MP0005380_embryogenesis_phenotype0.72717290
79MP0009333_abnormal_splenocyte_physiolog0.72168952
80MP0004019_abnormal_vitamin_homeostasis0.70123847
81MP0002075_abnormal_coat/hair_pigmentati0.70103808
82MP0001502_abnormal_circadian_rhythm0.69120354
83MP0009643_abnormal_urine_homeostasis0.68781424
84MP0002090_abnormal_vision0.67577749
85MP0005319_abnormal_enzyme/_coenzyme0.67493767
86MP0005636_abnormal_mineral_homeostasis0.65681698
87MP0003453_abnormal_keratinocyte_physiol0.65040075
88MP0008260_abnormal_autophagy0.63618833
89MP0002085_abnormal_embryonic_tissue0.63018195
90MP0000751_myopathy0.62408884
91MP0002210_abnormal_sex_determination0.62015982
92MP0000490_abnormal_crypts_of0.61415178
93MP0009053_abnormal_anal_canal0.60701341
94MP0000627_abnormal_mammary_gland0.60625163
95MP0003984_embryonic_growth_retardation0.60173175
96MP0001216_abnormal_epidermal_layer0.59822091
97MP0000467_abnormal_esophagus_morphology0.58917148
98MP0005375_adipose_tissue_phenotype0.58357737
99MP0001944_abnormal_pancreas_morphology0.57640617
100MP0005384_cellular_phenotype0.56905034

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.87879304
2Acute necrotizing encephalopathy (HP:0006965)4.62497979
3Mitochondrial inheritance (HP:0001427)4.37305608
4Acute encephalopathy (HP:0006846)4.31830287
5Testicular atrophy (HP:0000029)4.24452796
6Increased CSF lactate (HP:0002490)4.11186102
7Hepatocellular necrosis (HP:0001404)4.11108281
8Increased intramyocellular lipid droplets (HP:0012240)4.09189117
9Hepatic necrosis (HP:0002605)3.84196963
10Increased muscle lipid content (HP:0009058)3.80263069
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.79270577
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.79270577
13Progressive macrocephaly (HP:0004481)3.60529912
14Lipid accumulation in hepatocytes (HP:0006561)3.59695323
15Increased hepatocellular lipid droplets (HP:0006565)3.58481946
16Type I transferrin isoform profile (HP:0003642)3.56262222
17Renal Fanconi syndrome (HP:0001994)3.51885378
18Cerebral edema (HP:0002181)3.41461191
19Lactic acidosis (HP:0003128)3.23374152
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19796700
21Exercise intolerance (HP:0003546)3.18493760
22Increased serum lactate (HP:0002151)3.15251276
23Ragged-red muscle fibers (HP:0003200)3.04823041
24Progressive muscle weakness (HP:0003323)2.99330738
25Microvesicular hepatic steatosis (HP:0001414)2.99157976
26Abnormal number of erythroid precursors (HP:0012131)2.95221837
27Abnormality of glycolysis (HP:0004366)2.94023482
28Abnormal protein glycosylation (HP:0012346)2.93088923
29Abnormal glycosylation (HP:0012345)2.93088923
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.93088923
31Abnormal protein N-linked glycosylation (HP:0012347)2.93088923
32Hypokinesia (HP:0002375)2.86459473
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86115543
34Respiratory failure (HP:0002878)2.80493023
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.80342731
36Abnormality of cells of the erythroid lineage (HP:0012130)2.79965183
37Microretrognathia (HP:0000308)2.76864424
38Reduced antithrombin III activity (HP:0001976)2.74571518
39Increased serum pyruvate (HP:0003542)2.63401167
40Reticulocytopenia (HP:0001896)2.56078469
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52444513
42Degeneration of anterior horn cells (HP:0002398)2.49115893
43Abnormality of the anterior horn cell (HP:0006802)2.49115893
44Rough bone trabeculation (HP:0100670)2.43196981
45Lethargy (HP:0001254)2.32921935
46Opisthotonus (HP:0002179)2.32272000
47Hyperthyroidism (HP:0000836)2.31676553
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27773536
49Dicarboxylic aciduria (HP:0003215)2.27773536
50Macrocytic anemia (HP:0001972)2.26670425
51Cerebral hypomyelination (HP:0006808)2.21469167
52Respiratory difficulties (HP:0002880)2.16968606
53Trismus (HP:0000211)2.12237309
54Progressive microcephaly (HP:0000253)2.11530616
55Abnormal trabecular bone morphology (HP:0100671)2.11476340
56Birth length less than 3rd percentile (HP:0003561)2.08069824
57Pancytopenia (HP:0001876)2.07587412
58Leukodystrophy (HP:0002415)2.07331345
59Abnormality of the umbilical cord (HP:0010881)2.05639098
60Sparse eyelashes (HP:0000653)2.04940045
61Methylmalonic aciduria (HP:0012120)2.04405496
62Truncus arteriosus (HP:0001660)2.02709925
63Abnormality of methionine metabolism (HP:0010901)2.02262711
64Hyperammonemia (HP:0001987)1.97735793
65Vertebral compression fractures (HP:0002953)1.97439694
66Exertional dyspnea (HP:0002875)1.95435558
67Spastic paraparesis (HP:0002313)1.94871609
68Absent thumb (HP:0009777)1.94712416
69Emotional lability (HP:0000712)1.92225242
70Abnormalities of placenta or umbilical cord (HP:0001194)1.92120930
71Megaloblastic anemia (HP:0001889)1.91313614
72Villous atrophy (HP:0011473)1.90005369
73Abnormality of small intestinal villus morphology (HP:0011472)1.90005369
74Gout (HP:0001997)1.89014345
75Prolonged neonatal jaundice (HP:0006579)1.88902352
76Generalized aminoaciduria (HP:0002909)1.88760668
77Abnormal gallbladder physiology (HP:0012438)1.87249351
78Cholecystitis (HP:0001082)1.87249351
79Poikiloderma (HP:0001029)1.87138130
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83933442
81CNS demyelination (HP:0007305)1.83686166
82Patchy hypopigmentation of hair (HP:0011365)1.83140205
83Multiple enchondromatosis (HP:0005701)1.82847611
84Squamous cell carcinoma (HP:0002860)1.81831888
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81410365
86Selective tooth agenesis (HP:0001592)1.78882328
87Cutaneous melanoma (HP:0012056)1.77477051
88Death in infancy (HP:0001522)1.77317713
89Unilateral renal agenesis (HP:0000122)1.76583251
90Diminished movement (HP:0002374)1.76477320
91Rib fusion (HP:0000902)1.75607243
92Optic disc pallor (HP:0000543)1.75265823
93Abnormality of placental membranes (HP:0011409)1.73643808
94Amniotic constriction ring (HP:0009775)1.73643808
95Premature graying of hair (HP:0002216)1.70332838
96Hyperinsulinemic hypoglycemia (HP:0000825)1.70276043
97Abnormality of renal resorption (HP:0011038)1.67851193
98Congenital malformation of the right heart (HP:0011723)1.65504358
99Double outlet right ventricle (HP:0001719)1.65504358
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65265442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.89561514
2VRK24.35690902
3BUB14.06790232
4BCKDK2.93020627
5STK162.74011210
6TESK22.69873495
7PBK2.62521308
8SCYL22.38891624
9ARAF2.32642867
10TESK12.31608751
11EIF2AK12.18161922
12EPHA22.15864937
13KDR2.14377038
14IRAK32.11946092
15ZAK2.04913190
16PIM22.04794607
17MST1R1.94250842
18LIMK11.87481828
19TLK11.80970841
20NEK11.80504734
21NME11.64692228
22SRPK11.64106136
23SMG11.63357434
24PRKD31.57397878
25ABL21.56398541
26PDK21.55735423
27CDC71.54703087
28CSNK1G31.47948240
29VRK11.44924069
30TRIB31.39563328
31PAK41.37680938
32BRSK11.32035270
33AURKA1.31069797
34WEE11.22772243
35CSNK1A1L1.17017726
36PLK11.11956947
37DAPK11.10143039
38TTK1.09930790
39BRAF1.09800714
40LRRK21.06279575
41MAP3K111.04728086
42CSNK1G11.04501081
43TRIM281.03330969
44MST41.02226564
45CDK70.98263651
46AURKB0.94667342
47ILK0.93493347
48CSNK1G20.90669627
49CDK80.90127620
50CHEK20.87995332
51MUSK0.86864022
52TSSK60.86629596
53ATR0.85669612
54PRKCI0.85481565
55TAOK20.82078534
56RPS6KB20.80188964
57TAF10.75454675
58MAPKAPK30.74914912
59LMTK20.71504171
60MAP3K80.70526353
61RPS6KA50.69953709
62PHKG20.69189515
63PHKG10.69189515
64DAPK30.66424194
65MAP3K120.66082422
66MAP3K30.65911496
67PLK30.65694567
68MET0.63984938
69IRAK20.62953892
70CAMK2G0.62094603
71AKT20.61308673
72PAK10.61003409
73MAP2K60.60377684
74WNK40.59964360
75ERN10.57529448
76STK40.55990009
77DYRK20.53643849
78SIK10.52808995
79RPS6KA40.51779559
80CCNB10.50824786
81CSNK2A10.48460997
82CSNK2A20.47480671
83CHEK10.44654712
84CAMK2D0.41502250
85CDK40.40201453
86MAP2K70.39938258
87CDK140.37348377
88CDK11A0.37008231
89EIF2AK30.36551010
90CDK150.34917533
91CDK180.34661078
92MAPK150.34551948
93FLT30.32605815
94PTK20.31141373
95PKN20.30581231
96EIF2AK20.29609989
97SIK30.28168292
98MAP2K20.25411965
99TBK10.25390621
100MAPK110.24681527

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.01524255
2DNA replication_Homo sapiens_hsa030303.33746186
3Sulfur relay system_Homo sapiens_hsa041223.31075093
4Ribosome_Homo sapiens_hsa030103.08703477
5Oxidative phosphorylation_Homo sapiens_hsa001903.07509875
6Base excision repair_Homo sapiens_hsa034102.64294217
7Parkinsons disease_Homo sapiens_hsa050122.64190430
8Mismatch repair_Homo sapiens_hsa034302.62256690
9RNA polymerase_Homo sapiens_hsa030202.45642159
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44753869
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40762947
12Pyrimidine metabolism_Homo sapiens_hsa002402.17298761
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13846218
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13703155
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98464862
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93752065
17Huntingtons disease_Homo sapiens_hsa050161.90597668
18Biosynthesis of amino acids_Homo sapiens_hsa012301.87875726
19Homologous recombination_Homo sapiens_hsa034401.86695731
20Fatty acid elongation_Homo sapiens_hsa000621.85426587
21Alzheimers disease_Homo sapiens_hsa050101.75094076
22Folate biosynthesis_Homo sapiens_hsa007901.60001314
23Pyruvate metabolism_Homo sapiens_hsa006201.57277091
24One carbon pool by folate_Homo sapiens_hsa006701.57043653
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55734306
26Nucleotide excision repair_Homo sapiens_hsa034201.54692300
27Sulfur metabolism_Homo sapiens_hsa009201.51574482
28Carbon metabolism_Homo sapiens_hsa012001.49994717
29Glutathione metabolism_Homo sapiens_hsa004801.48195438
30Fructose and mannose metabolism_Homo sapiens_hsa000511.47469886
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.46771484
32Vitamin B6 metabolism_Homo sapiens_hsa007501.42734730
33Spliceosome_Homo sapiens_hsa030401.37095102
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34370703
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33736276
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29285156
37Fanconi anemia pathway_Homo sapiens_hsa034601.28346946
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.26255232
39Protein export_Homo sapiens_hsa030601.22479806
40Purine metabolism_Homo sapiens_hsa002301.18376867
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17751934
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16267484
43Pentose phosphate pathway_Homo sapiens_hsa000301.12946203
44RNA transport_Homo sapiens_hsa030131.10860784
45N-Glycan biosynthesis_Homo sapiens_hsa005101.09144587
46Galactose metabolism_Homo sapiens_hsa000521.08113146
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05103361
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96426648
49Arginine and proline metabolism_Homo sapiens_hsa003300.95103010
50Non-homologous end-joining_Homo sapiens_hsa034500.94573926
51Metabolic pathways_Homo sapiens_hsa011000.94053303
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92322715
53Phenylalanine metabolism_Homo sapiens_hsa003600.91084611
54Cardiac muscle contraction_Homo sapiens_hsa042600.87483346
55Peroxisome_Homo sapiens_hsa041460.84619641
56Vibrio cholerae infection_Homo sapiens_hsa051100.83880568
57Cell cycle_Homo sapiens_hsa041100.81618587
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.79076874
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77908284
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76958407
61Tyrosine metabolism_Homo sapiens_hsa003500.75690650
62Fatty acid metabolism_Homo sapiens_hsa012120.75415213
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72816482
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70092110
65Other glycan degradation_Homo sapiens_hsa005110.67276276
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64136117
67Arginine biosynthesis_Homo sapiens_hsa002200.62866574
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.60971584
69Steroid biosynthesis_Homo sapiens_hsa001000.56059103
70Fatty acid degradation_Homo sapiens_hsa000710.55612263
71RNA degradation_Homo sapiens_hsa030180.55486071
72Propanoate metabolism_Homo sapiens_hsa006400.53489206
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52861115
74Basal transcription factors_Homo sapiens_hsa030220.47699433
75Collecting duct acid secretion_Homo sapiens_hsa049660.45029838
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44375084
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44052991
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42886640
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40672771
80beta-Alanine metabolism_Homo sapiens_hsa004100.39232995
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34583894
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.34566272
83Selenocompound metabolism_Homo sapiens_hsa004500.34260108
84Lysosome_Homo sapiens_hsa041420.31479612
85Sphingolipid metabolism_Homo sapiens_hsa006000.30048597
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29697031
87p53 signaling pathway_Homo sapiens_hsa041150.29007422
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25077645
89Butanoate metabolism_Homo sapiens_hsa006500.22534692
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.21234792
91Vitamin digestion and absorption_Homo sapiens_hsa049770.21081381
92Chemical carcinogenesis_Homo sapiens_hsa052040.20768855
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20121685
94Epstein-Barr virus infection_Homo sapiens_hsa051690.19513873
95mRNA surveillance pathway_Homo sapiens_hsa030150.19002516
96Oocyte meiosis_Homo sapiens_hsa041140.17244038
97Tryptophan metabolism_Homo sapiens_hsa003800.14121153
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11473090
99Bladder cancer_Homo sapiens_hsa052190.10557148
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.10217718

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