NBAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1enteric nervous system development (GO:0048484)9.20217472
2nuclear pore complex assembly (GO:0051292)8.79238883
3nuclear pore organization (GO:0006999)8.08642776
4negative regulation of dendrite morphogenesis (GO:0050774)7.74900640
5Golgi transport vesicle coating (GO:0048200)6.66240084
6COPI coating of Golgi vesicle (GO:0048205)6.66240084
7pore complex assembly (GO:0046931)6.60536495
8sympathetic nervous system development (GO:0048485)6.59773699
9behavioral response to nicotine (GO:0035095)6.26040087
10ganglion development (GO:0061548)6.16893380
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.86203573
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.86203573
13positive regulation of cell cycle checkpoint (GO:1901978)5.42483055
14regulation of secondary heart field cardioblast proliferation (GO:0003266)5.13168933
15regulation of cardioblast proliferation (GO:0003264)5.13168933
16cell migration in hindbrain (GO:0021535)4.68007382
17DNA duplex unwinding (GO:0032508)4.60137090
18regulation of centrosome duplication (GO:0010824)4.52664059
19DNA geometric change (GO:0032392)4.50565753
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.46553806
21coronary vasculature morphogenesis (GO:0060977)4.40362343
22negative regulation of dendrite development (GO:2000171)4.31835049
23COPII vesicle coating (GO:0048208)4.31781157
24regulation of centriole replication (GO:0046599)4.29091852
25macroautophagy (GO:0016236)4.19172490
26regulation of centrosome cycle (GO:0046605)4.10961064
27regulation of histone H3-K9 methylation (GO:0051570)4.05731059
28positive regulation of transcription regulatory region DNA binding (GO:2000679)4.04552786
29DNA unwinding involved in DNA replication (GO:0006268)4.04547270
30positive regulation of cell cycle G2/M phase transition (GO:1902751)3.99872253
31positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.99872253
32negative regulation of astrocyte differentiation (GO:0048712)3.98061529
33activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.97157971
34dopaminergic neuron differentiation (GO:0071542)3.95153167
35negative regulation of DNA repair (GO:0045738)3.92118001
36neuromuscular synaptic transmission (GO:0007274)3.80011211
37mitotic sister chromatid cohesion (GO:0007064)3.76321366
38protein targeting to Golgi (GO:0000042)3.76268397
39regulation of heart morphogenesis (GO:2000826)3.72514976
40regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.70918394
41positive regulation of nuclease activity (GO:0032075)3.70113182
42ER overload response (GO:0006983)3.68392077
43vesicle coating (GO:0006901)3.63772513
44establishment of protein localization to Golgi (GO:0072600)3.61490399
45non-recombinational repair (GO:0000726)3.50147742
46double-strand break repair via nonhomologous end joining (GO:0006303)3.50147742
47sister chromatid segregation (GO:0000819)3.48489182
48regulation of RNA export from nucleus (GO:0046831)3.45902270
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44124417
50retrograde transport, vesicle recycling within Golgi (GO:0000301)3.36354724
51cell migration involved in heart development (GO:0060973)3.36123169
52regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.33283467
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32370933
54endoplasmic reticulum unfolded protein response (GO:0030968)3.31554408
55regulation of nuclease activity (GO:0032069)3.31098747
56intra-Golgi vesicle-mediated transport (GO:0006891)3.31079897
57cellular response to unfolded protein (GO:0034620)3.28101422
58DNA conformation change (GO:0071103)3.26059401
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24501420
60regulation of mitotic spindle checkpoint (GO:1903504)3.24501420
61ER-nucleus signaling pathway (GO:0006984)3.22770781
62endocrine pancreas development (GO:0031018)3.22058551
63midgut development (GO:0007494)3.21254831
64pre-miRNA processing (GO:0031054)3.17970429
65mitotic nuclear envelope disassembly (GO:0007077)3.17830826
66negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.17709909
67ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.15523203
68mitotic sister chromatid segregation (GO:0000070)3.08853186
69DNA replication-dependent nucleosome organization (GO:0034723)3.07161665
70DNA replication-dependent nucleosome assembly (GO:0006335)3.07161665
71spliceosomal complex assembly (GO:0000245)3.05747077
72nuclear envelope disassembly (GO:0051081)3.03586478
73membrane disassembly (GO:0030397)3.03586478
74cellular response to topologically incorrect protein (GO:0035967)3.03577640
75replication fork processing (GO:0031297)3.03454630
76exocrine pancreas development (GO:0031017)3.03147613
77DNA replication initiation (GO:0006270)3.01381754
78dosage compensation (GO:0007549)3.01090013
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.00307490
80somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00307490
81cartilage morphogenesis (GO:0060536)2.99707811
82regulation of NFAT protein import into nucleus (GO:0051532)2.98387463
83mitotic chromosome condensation (GO:0007076)2.96009884
84peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.93306882
85retinal rod cell development (GO:0046548)2.89899396
86nerve growth factor signaling pathway (GO:0038180)2.89318745
87mitotic recombination (GO:0006312)2.86985944
88regulation of sister chromatid cohesion (GO:0007063)2.86641929
89regulation of respiratory gaseous exchange (GO:0043576)2.85862101
90lipid translocation (GO:0034204)2.85702299
91phospholipid translocation (GO:0045332)2.85702299
92endocardial cushion morphogenesis (GO:0003203)2.85652350
93Golgi organization (GO:0007030)2.85424548
94central nervous system neuron axonogenesis (GO:0021955)2.85041956
95peptide hormone processing (GO:0016486)2.84813099
96activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.83693706
97positive regulation of glycolytic process (GO:0045821)2.82424626
98regulation of ARF protein signal transduction (GO:0032012)2.82202271
99DNA synthesis involved in DNA repair (GO:0000731)2.82196614
100negative regulation of DNA recombination (GO:0045910)2.82095843
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.82021166
102negative regulation of cell cycle arrest (GO:0071157)2.81609068
103insulin secretion (GO:0030073)2.81071606
104regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.80828982
105intestinal cholesterol absorption (GO:0030299)2.79917478
106telomere maintenance via recombination (GO:0000722)2.78564308
107type B pancreatic cell development (GO:0003323)2.76536704
108kinetochore organization (GO:0051383)2.76036691
109suckling behavior (GO:0001967)2.75961842
110metaphase plate congression (GO:0051310)2.75754497
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74735316
112histone H3-K9 demethylation (GO:0033169)2.73397564
113L-phenylalanine catabolic process (GO:0006559)2.73306072
114erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73306072
115endoplasmic reticulum organization (GO:0007029)2.72989791
116cerebellar Purkinje cell layer development (GO:0021680)2.70454647
117regulation of cell cycle G2/M phase transition (GO:1902749)2.69900659
118response to endoplasmic reticulum stress (GO:0034976)2.69781063
119regulation of nucleobase-containing compound transport (GO:0032239)2.69111768
120double-strand break repair (GO:0006302)2.68478187
121protein retention in ER lumen (GO:0006621)2.68195515
122regulation of translational fidelity (GO:0006450)2.66201103
123DNA topological change (GO:0006265)2.66083343
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63838235
125tongue development (GO:0043586)2.62568475
126resolution of meiotic recombination intermediates (GO:0000712)2.61838743
127histone H3-K9 methylation (GO:0051567)2.61801240
128regulation of spindle checkpoint (GO:0090231)2.61557880
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.61459953
130response to unfolded protein (GO:0006986)2.61111837
131nucleus organization (GO:0006997)2.60379972
132adult heart development (GO:0007512)2.59339473
133protein prenylation (GO:0018342)2.58619430
134prenylation (GO:0097354)2.58619430
135definitive hemopoiesis (GO:0060216)2.56311140
136negative regulation of neurotransmitter secretion (GO:0046929)2.55953065
137mesenchyme morphogenesis (GO:0072132)2.53402253
138positive regulation of glycogen biosynthetic process (GO:0045725)2.53075595
139negative regulation of histone methylation (GO:0031061)2.52271353
140regulation of respiratory system process (GO:0044065)2.52021426
141regulation of chromosome segregation (GO:0051983)2.51052160
142peptidyl-lysine dimethylation (GO:0018027)2.50229439
143negative regulation of chromosome segregation (GO:0051985)2.50150270
144asymmetric protein localization (GO:0008105)2.49869598
145response to lipoprotein particle (GO:0055094)2.48988705
146protein maturation by protein folding (GO:0022417)2.47116935
147response to topologically incorrect protein (GO:0035966)2.46452128
148positive regulation of histone deacetylation (GO:0031065)2.45144721
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.43942742
150cytoplasmic mRNA processing body assembly (GO:0033962)2.43037197
151apical protein localization (GO:0045176)2.42667087
152Golgi to endosome transport (GO:0006895)2.41930274
153protein localization to Golgi apparatus (GO:0034067)2.41431829
154response to hepatocyte growth factor (GO:0035728)2.40048784
155cellular response to hepatocyte growth factor stimulus (GO:0035729)2.40048784
156regulation of glucocorticoid secretion (GO:2000849)2.39313554
157long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.37590874
158embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36160529
159detection of calcium ion (GO:0005513)2.35547622
160negative regulation of inclusion body assembly (GO:0090084)2.35125296
161glandular epithelial cell differentiation (GO:0002067)2.33271830
1624-hydroxyproline metabolic process (GO:0019471)2.32991501
163fatty-acyl-CoA biosynthetic process (GO:0046949)2.29613537
164negative regulation of glycogen biosynthetic process (GO:0045719)2.27200297
165potassium ion import (GO:0010107)2.26751740
166lactate metabolic process (GO:0006089)2.25493598
167cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24900493
168L-phenylalanine metabolic process (GO:0006558)2.24247997
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.24247997
170peptidyl-asparagine modification (GO:0018196)2.23459450
171positive regulation of glycogen metabolic process (GO:0070875)2.22950105
172protein N-linked glycosylation via asparagine (GO:0018279)2.22787381
173positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.22309269
174L-alpha-amino acid transmembrane transport (GO:1902475)2.21997563
175creatine metabolic process (GO:0006600)2.20405485
176sequestering of metal ion (GO:0051238)2.19498169
177inner ear receptor cell development (GO:0060119)2.19337259
178axon ensheathment in central nervous system (GO:0032291)2.18887723
179central nervous system myelination (GO:0022010)2.18887723
180intestinal absorption (GO:0050892)2.18321613
181regulation of beta-amyloid formation (GO:1902003)2.15687709
182activation of protein kinase A activity (GO:0034199)2.14512778
183vesicle transport along microtubule (GO:0047496)2.13801909
184glandular epithelial cell development (GO:0002068)2.13473453
185myelin maintenance (GO:0043217)2.13096765
186regulation of glucose import in response to insulin stimulus (GO:2001273)2.13005751
187regulation of insulin secretion (GO:0050796)2.12880693
188hormone catabolic process (GO:0042447)2.12152690
189positive regulation of insulin secretion (GO:0032024)2.11802055
190chemosensory behavior (GO:0007635)2.11235277
191negative regulation of glycogen metabolic process (GO:0070874)2.10446572
192acyl-CoA biosynthetic process (GO:0071616)2.10365942
193thioester biosynthetic process (GO:0035384)2.10365942
194Golgi vesicle transport (GO:0048193)2.10101110
195alpha-linolenic acid metabolic process (GO:0036109)2.09446613
196protein N-linked glycosylation (GO:0006487)2.09428632
197phospholipid homeostasis (GO:0055091)2.08282096
198ER to Golgi vesicle-mediated transport (GO:0006888)2.08211112
199photoreceptor cell differentiation (GO:0046530)2.06111589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.15381957
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.78148002
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.67216047
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80978286
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.29076049
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.96660412
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75059159
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55096056
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.46117047
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22730918
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22022647
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14144678
13TCF4_18268006_ChIP-ChIP_LS174T_Human2.07658020
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04657188
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03974759
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.01568306
17FUS_26573619_Chip-Seq_HEK293_Human1.99115381
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97555841
19GBX2_23144817_ChIP-Seq_PC3_Human1.95835318
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85915535
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82462425
22DROSHA_22980978_ChIP-Seq_HELA_Human1.82459562
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.80235724
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.78245797
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76354274
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.71399875
27* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70847394
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65874202
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.61876263
30EZH2_22144423_ChIP-Seq_EOC_Human1.59933763
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57015807
32ZNF274_21170338_ChIP-Seq_K562_Hela1.56413469
33IGF1R_20145208_ChIP-Seq_DFB_Human1.56276912
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55086702
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.53213548
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52174954
37AR_21909140_ChIP-Seq_LNCAP_Human1.51228027
38STAT3_23295773_ChIP-Seq_U87_Human1.50686469
39* ETV1_20927104_ChIP-Seq_GIST48_Human1.50068433
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48941286
41AHR_22903824_ChIP-Seq_MCF-7_Human1.47957452
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46991637
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45281047
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44904535
45* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.44649417
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43788387
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.43572585
48* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.42075346
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42024819
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40780970
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.40416571
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39022095
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38051640
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37598391
55SMAD4_21799915_ChIP-Seq_A2780_Human1.37458858
56* SOX9_26525672_Chip-Seq_HEART_Mouse1.35946187
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35900538
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35448407
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33562039
60* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33525028
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33250316
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32956729
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32807806
64* TCF4_23295773_ChIP-Seq_U87_Human1.32596189
65ELK1_19687146_ChIP-ChIP_HELA_Human1.31992029
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30123139
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30039127
68* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.28662456
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28611041
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28607186
71EWS_26573619_Chip-Seq_HEK293_Human1.28223584
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.26026264
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25864869
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25421354
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25080592
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23930492
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23813595
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.23385084
79* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23194040
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22964006
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22132851
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.21943667
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20889919
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20802698
85P300_19829295_ChIP-Seq_ESCs_Human1.19550769
86* REST_21632747_ChIP-Seq_MESCs_Mouse1.19176303
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18457167
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16442490
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15005095
90BCAT_22108803_ChIP-Seq_LS180_Human1.14431327
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.14423124
92* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14316010
93AR_19668381_ChIP-Seq_PC3_Human1.13915470
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11928078
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11928078
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11539812
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10185453
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09121457
99TAF15_26573619_Chip-Seq_HEK293_Human1.08974206
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.08199996
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.07884757
102* GATA1_22025678_ChIP-Seq_K562_Human1.07339822
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.07299116
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.06748836
105* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06724327
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.05599199
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05493011
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05054238
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04843008
110* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04174798
111RBPJ_21746931_ChIP-Seq_IB4_Human1.04099876
112NFYB_21822215_ChIP-Seq_K562_Human1.03561874
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.03347274
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02545115
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02474204
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00194760
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00078820
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99871460
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.98998189
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97812688
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97113236
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96640509
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.96322152
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.95533327
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.95533327
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95266786
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95042939
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.94723775
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94696559
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94688959
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.94669151
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94321738
133STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94317156
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94208804
135CDX2_22108803_ChIP-Seq_LS180_Human0.93874538
136MYC_18555785_ChIP-Seq_MESCs_Mouse0.93704211
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92675624
138TBL1_22424771_ChIP-Seq_293T_Human0.92164618
139P53_22387025_ChIP-Seq_ESCs_Mouse0.92086894
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.91956234
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91909877
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91660895
143GATA1_19941826_ChIP-Seq_K562_Human0.91463070
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91179625
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.90236167
146* FLI1_21867929_ChIP-Seq_TH2_Mouse0.90125087
147TP63_23658742_ChIP-Seq_EP156T_Human0.89972211
148SALL4_22934838_ChIP-ChIP_CD34+_Human0.89533559
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88130866
150* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87820265
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87793390
152AR_25329375_ChIP-Seq_VCAP_Human0.87007467
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.86722789
154NFYA_21822215_ChIP-Seq_K562_Human0.86692091
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86326069
156GF1B_26923725_Chip-Seq_HPCs_Mouse0.86314953
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86172776
158OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86167873
159* TAL1_26923725_Chip-Seq_HPCs_Mouse0.85008891
160TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84694967
161CLOCK_20551151_ChIP-Seq_293T_Human0.84241965
162* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83880912
163PHF8_20622853_ChIP-Seq_HELA_Human0.83499916
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82989532
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82643942
166TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82515990
167BRD4_25478319_ChIP-Seq_HGPS_Human0.82455194
168SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82043639
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82004127
170RUNX2_22187159_ChIP-Seq_PCA_Human0.81643583
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81066964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex7.62016668
2MP0009780_abnormal_chondrocyte_physiolo4.22818464
3MP0008057_abnormal_DNA_replication4.01142474
4MP0003283_abnormal_digestive_organ3.91598067
5MP0002751_abnormal_autonomic_nervous3.64997503
6MP0002822_catalepsy3.54218612
7MP0003567_abnormal_fetal_cardiomyocyte3.12194396
8MP0004043_abnormal_pH_regulation2.87108355
9MP0003252_abnormal_bile_duct2.78192474
10MP0003183_abnormal_peptide_metabolism2.70594424
11MP0010352_gastrointestinal_tract_polyps2.69935335
12MP0002139_abnormal_hepatobiliary_system2.69223671
13MP0002909_abnormal_adrenal_gland2.64598850
14MP0002009_preneoplasia2.56612361
15MP0000569_abnormal_digit_pigmentation2.53586733
16MP0000013_abnormal_adipose_tissue2.52225831
17MP0002877_abnormal_melanocyte_morpholog2.48620390
18MP0005365_abnormal_bile_salt2.37501148
19MP0010094_abnormal_chromosome_stability2.31485760
20MP0002693_abnormal_pancreas_physiology2.25559831
21MP0001944_abnormal_pancreas_morphology2.21245954
22MP0003195_calcinosis2.18987275
23MP0006276_abnormal_autonomic_nervous2.08479447
24MP0003045_fibrosis2.07957833
25MP0004270_analgesia2.06788047
26MP0003300_gastrointestinal_ulcer2.04333978
27MP0000003_abnormal_adipose_tissue2.01130718
28MP0003077_abnormal_cell_cycle2.00646247
29MP0001666_abnormal_nutrient_absorption1.94810628
30MP0005220_abnormal_exocrine_pancreas1.93966893
31MP0009697_abnormal_copulation1.92525649
32MP0005187_abnormal_penis_morphology1.91071522
33MP0002697_abnormal_eye_size1.88748376
34MP0001299_abnormal_eye_distance/1.87679465
35MP0003868_abnormal_feces_composition1.84649154
36MP0008438_abnormal_cutaneous_collagen1.81075392
37MP0003111_abnormal_nucleus_morphology1.80817959
38MP0005410_abnormal_fertilization1.80576144
39MP0005197_abnormal_uvea_morphology1.77035165
40MP0006138_congestive_heart_failure1.76911229
41MP0001270_distended_abdomen1.73038291
42MP0010307_abnormal_tumor_latency1.72878869
43MP0002837_dystrophic_cardiac_calcinosis1.72531208
44MP0010386_abnormal_urinary_bladder1.71290016
45MP0000462_abnormal_digestive_system1.64666441
46MP0005085_abnormal_gallbladder_physiolo1.63949199
47MP0002078_abnormal_glucose_homeostasis1.63574373
48MP0003172_abnormal_lysosome_physiology1.60281642
49MP0002127_abnormal_cardiovascular_syste1.57730584
50MP0002896_abnormal_bone_mineralization1.56702227
51MP0003690_abnormal_glial_cell1.54426955
52MP0008058_abnormal_DNA_repair1.53197138
53MP0001661_extended_life_span1.50196222
54MP0005391_vision/eye_phenotype1.50089398
55MP0000920_abnormal_myelination1.49774232
56MP0004957_abnormal_blastocyst_morpholog1.46147288
57MP0005375_adipose_tissue_phenotype1.45044422
58MP0005646_abnormal_pituitary_gland1.44221049
59MP0003937_abnormal_limbs/digits/tail_de1.43901696
60MP0004264_abnormal_extraembryonic_tissu1.41571460
61MP0010234_abnormal_vibrissa_follicle1.40577646
62MP0005670_abnormal_white_adipose1.39489920
63MP0003329_amyloid_beta_deposits1.39141673
64MP0000538_abnormal_urinary_bladder1.36670180
65MP0005058_abnormal_lysosome_morphology1.33381328
66MP0008007_abnormal_cellular_replicative1.32832148
67MP0002184_abnormal_innervation1.32308017
68MP0008932_abnormal_embryonic_tissue1.31498720
69MP0003890_abnormal_embryonic-extraembry1.31219317
70MP0003935_abnormal_craniofacial_develop1.30532352
71MP0005360_urolithiasis1.27627303
72MP0003634_abnormal_glial_cell1.26202437
73MP0002118_abnormal_lipid_homeostasis1.21752933
74MP0001730_embryonic_growth_arrest1.19707050
75MP0005666_abnormal_adipose_tissue1.19020298
76MP0006072_abnormal_retinal_apoptosis1.18864431
77MP0008961_abnormal_basal_metabolism1.18152728
78MP0001765_abnormal_ion_homeostasis1.17323896
79MP0002229_neurodegeneration1.16553785
80MP0002084_abnormal_developmental_patter1.15413809
81MP0003984_embryonic_growth_retardation1.13181313
82MP0004197_abnormal_fetal_growth/weight/1.13129002
83MP0002088_abnormal_embryonic_growth/wei1.12211586
84MP0004130_abnormal_muscle_cell1.11777977
85MP0002108_abnormal_muscle_morphology1.10189412
86MP0001672_abnormal_embryogenesis/_devel1.09983452
87MP0005380_embryogenesis_phenotype1.09983452
88MP0003693_abnormal_embryo_hatching1.09641841
89MP0004185_abnormal_adipocyte_glucose1.09262830
90MP0005379_endocrine/exocrine_gland_phen1.08798903
91MP0002928_abnormal_bile_duct1.08446755
92MP0002168_other_aberrant_phenotype1.05205015
93MP0005551_abnormal_eye_electrophysiolog1.00450365
94MP0010329_abnormal_lipoprotein_level0.99651594
95MP0001697_abnormal_embryo_size0.97707082
96MP0002085_abnormal_embryonic_tissue0.96953401
97MP0003705_abnormal_hypodermis_morpholog0.96867609
98MP0003632_abnormal_nervous_system0.96564166
99MP0005083_abnormal_biliary_tract0.96127435
100MP0003953_abnormal_hormone_level0.96076054
101MP0002086_abnormal_extraembryonic_tissu0.93089163
102MP0002092_abnormal_eye_morphology0.91683285
103MP0004036_abnormal_muscle_relaxation0.91605904
104MP0005535_abnormal_body_temperature0.91359927
105MP0000604_amyloidosis0.90649695
106MP0003943_abnormal_hepatobiliary_system0.90647069
107MP0009384_cardiac_valve_regurgitation0.90032091
108MP0003136_yellow_coat_color0.88957944
109MP0003633_abnormal_nervous_system0.88667725
110MP0002295_abnormal_pulmonary_circulatio0.86990952
111MP0005253_abnormal_eye_physiology0.86799528
112MP0004233_abnormal_muscle_weight0.86326079
113MP0005076_abnormal_cell_differentiation0.85967688
114MP0000428_abnormal_craniofacial_morphol0.85555598
115MP0001293_anophthalmia0.85389421
116MP0000747_muscle_weakness0.85318820
117MP0004145_abnormal_muscle_electrophysio0.84725414
118MP0001324_abnormal_eye_pigmentation0.84644717
119MP0002090_abnormal_vision0.84032483
120MP0004811_abnormal_neuron_physiology0.84011345
121MP0004808_abnormal_hematopoietic_stem0.83749041
122MP0006054_spinal_hemorrhage0.83418609
123MP0001486_abnormal_startle_reflex0.82772012
124MP0002734_abnormal_mechanical_nocicepti0.82190694
125MP0004885_abnormal_endolymph0.81343661
126MP0003115_abnormal_respiratory_system0.80937619
127MP0003959_abnormal_lean_body0.80927549
128MP0002234_abnormal_pharynx_morphology0.79540363
129MP0003656_abnormal_erythrocyte_physiolo0.79091769
130MP0005386_behavior/neurological_phenoty0.78676847
131MP0004924_abnormal_behavior0.78676847
132MP0000372_irregular_coat_pigmentation0.78530879
133MP0005171_absent_coat_pigmentation0.78241421
134MP0002882_abnormal_neuron_morphology0.77955071
135MP0005195_abnormal_posterior_eye0.77799590
136MP0003631_nervous_system_phenotype0.76049037
137MP0005448_abnormal_energy_balance0.75630392
138MP0010678_abnormal_skin_adnexa0.75597796
139MP0003861_abnormal_nervous_system0.75510640
140MP0009643_abnormal_urine_homeostasis0.75437043
141MP0000955_abnormal_spinal_cord0.74878432
142MP0005408_hypopigmentation0.74865049
143MP0000350_abnormal_cell_proliferation0.74831083
144MP0002080_prenatal_lethality0.74764133
145MP0001502_abnormal_circadian_rhythm0.74303492
146MP0004272_abnormal_basement_membrane0.73969818
147MP0001756_abnormal_urination0.73942826
148MP0005395_other_phenotype0.73543670
149MP0003950_abnormal_plasma_membrane0.73442086
150MP0004147_increased_porphyrin_level0.72744376
151MP0009703_decreased_birth_body0.71491348
152MP0005645_abnormal_hypothalamus_physiol0.71146289
153MP0000631_abnormal_neuroendocrine_gland0.71107697
154MP0003385_abnormal_body_wall0.70982246
155MP0000609_abnormal_liver_physiology0.70955026
156MP0002269_muscular_atrophy0.70628765
157MP0004134_abnormal_chest_morphology0.70513001
158MP0004142_abnormal_muscle_tone0.70307343
159MP0000427_abnormal_hair_cycle0.69260195
160MP0005275_abnormal_skin_tensile0.69110849
161MP0002752_abnormal_somatic_nervous0.68908092
162MP0009672_abnormal_birth_weight0.68855942
163MP0002106_abnormal_muscle_physiology0.68325208
164MP0002272_abnormal_nervous_system0.68183894
165MP0004859_abnormal_synaptic_plasticity0.67251456
166MP0008770_decreased_survivor_rate0.67086566
167MP0002114_abnormal_axial_skeleton0.66053256
168MP0000432_abnormal_head_morphology0.64837426
169MP0005369_muscle_phenotype0.64418952
170MP0005084_abnormal_gallbladder_morpholo0.64368991
171MP0001915_intracranial_hemorrhage0.64153174
172MP0000477_abnormal_intestine_morphology0.64098038
173MP0000647_abnormal_sebaceous_gland0.63717865
174MP0000313_abnormal_cell_death0.62063862
175MP0005193_abnormal_anterior_eye0.61999115
176MP0003646_muscle_fatigue0.61789955
177MP0000759_abnormal_skeletal_muscle0.59354893

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)9.54258998
2Posterior subcapsular cataract (HP:0007787)8.32265397
3Intestinal atresia (HP:0011100)6.39785639
4Subcapsular cataract (HP:0000523)5.94163012
5Abnormality of the phalanges of the 2nd finger (HP:0009541)5.77417831
6Hyperinsulinemic hypoglycemia (HP:0000825)5.53555332
7Esophageal atresia (HP:0002032)5.40444338
8Breast hypoplasia (HP:0003187)5.02530184
9Supernumerary spleens (HP:0009799)4.87054958
10Scotoma (HP:0000575)4.81525220
11Hypoglycemic seizures (HP:0002173)4.60954720
12Depressed nasal tip (HP:0000437)4.37622223
13Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.23815621
14Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10356615
15Hypoglycemic coma (HP:0001325)3.90407892
16Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.88424748
17Annular pancreas (HP:0001734)3.88037458
18Chromsome breakage (HP:0040012)3.83062502
19Pancreatic islet-cell hyperplasia (HP:0004510)3.75448507
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.73262352
21Symptomatic seizures (HP:0011145)3.72858666
22Abnormality of the pancreatic islet cells (HP:0006476)3.68822847
23Abnormality of endocrine pancreas physiology (HP:0012093)3.68822847
24Tubulointerstitial fibrosis (HP:0005576)3.65423549
25Hyperglycemia (HP:0003074)3.55161458
26Hypoplastic nipples (HP:0002557)3.52403885
27Abnormality of the 2nd finger (HP:0004100)3.51874005
28Gastrointestinal atresia (HP:0002589)3.49306288
29Tubulointerstitial abnormality (HP:0001969)3.45236033
30Insulin-resistant diabetes mellitus (HP:0000831)3.43789646
31Ketoacidosis (HP:0001993)3.38099936
32Macroorchidism (HP:0000053)3.36493718
33Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.28416737
34Polar cataract (HP:0010696)3.13170095
35Secondary amenorrhea (HP:0000869)3.11652343
36Abnormality of the phalanges of the 5th finger (HP:0004213)3.04895909
37Large for gestational age (HP:0001520)3.01182067
38Asplenia (HP:0001746)3.01092264
39Intrahepatic cholestasis (HP:0001406)2.91720457
40Keratoconus (HP:0000563)2.78976456
41Increased corneal curvature (HP:0100692)2.78976456
42Abnormality of the intrinsic pathway (HP:0010989)2.78883955
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.71468290
44Type 2 muscle fiber atrophy (HP:0003554)2.71191577
45Conjugated hyperbilirubinemia (HP:0002908)2.64722216
46Abnormality of the vocal cords (HP:0008777)2.61834267
47Palpebral edema (HP:0100540)2.57528141
48EEG with generalized epileptiform discharges (HP:0011198)2.57067598
49Hypsarrhythmia (HP:0002521)2.56623736
50Abnormality of chromosome stability (HP:0003220)2.55108918
51Ketosis (HP:0001946)2.54687327
52Short palpebral fissure (HP:0012745)2.53901566
53Abnormality of the duodenum (HP:0002246)2.50137245
54Retinal atrophy (HP:0001105)2.49534260
55Tubulointerstitial nephritis (HP:0001970)2.48756169
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.43642198
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43642198
58Epileptiform EEG discharges (HP:0011182)2.42357956
59Neurofibrillary tangles (HP:0002185)2.42036868
60Neuroblastic tumors (HP:0004376)2.40902280
61Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.40902280
62Neuroblastoma (HP:0003006)2.40902280
63Primitive neuroectodermal tumor (HP:0030065)2.40902280
64Papillary thyroid carcinoma (HP:0002895)2.39118470
65Cortical dysplasia (HP:0002539)2.37185621
66Anteriorly placed anus (HP:0001545)2.37104028
67Turricephaly (HP:0000262)2.36100461
68Medulloblastoma (HP:0002885)2.34080736
69Hypotrichosis (HP:0001006)2.33524721
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.33311611
71Bony spicule pigmentary retinopathy (HP:0007737)2.28211620
72Thyroid carcinoma (HP:0002890)2.26600513
73Abnormality of the common coagulation pathway (HP:0010990)2.23889009
74Cerebral inclusion bodies (HP:0100314)2.23438343
75Abnormality of the ischium (HP:0003174)2.21873698
76Insidious onset (HP:0003587)2.21544986
77Termporal pattern (HP:0011008)2.21544986
78Wide anterior fontanel (HP:0000260)2.18644489
79Decreased skull ossification (HP:0004331)2.17882917
80Muscle fiber atrophy (HP:0100295)2.17160855
81Constricted visual fields (HP:0001133)2.16468646
82Pheochromocytoma (HP:0002666)2.16403737
83Hypoproteinemia (HP:0003075)2.16375556
84Cerebral aneurysm (HP:0004944)2.15569340
85Meckel diverticulum (HP:0002245)2.14755998
86Hyporeflexia of lower limbs (HP:0002600)2.12842659
87Hypoplastic ischia (HP:0003175)2.11968903
88Protuberant abdomen (HP:0001538)2.10197678
89Resting tremor (HP:0002322)2.08902818
90Poor suck (HP:0002033)2.07561486
91Aplasia/Hypoplasia of the nipples (HP:0006709)2.06470665
922-3 toe syndactyly (HP:0004691)2.05780413
93Hypoplastic labia majora (HP:0000059)2.05484258
94Abnormality of the ileum (HP:0001549)2.05381104
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04857420
96Fatigable weakness (HP:0003473)2.02390592
97Abnormality of the neuromuscular junction (HP:0003398)2.02390592
98Rhabdomyosarcoma (HP:0002859)2.02147930
99Spastic gait (HP:0002064)2.01765443
100Septo-optic dysplasia (HP:0100842)2.01568221
101Alacrima (HP:0000522)2.00742921
102Mucopolysacchariduria (HP:0008155)2.00367919
103Urinary glycosaminoglycan excretion (HP:0003541)2.00367919
104Late onset (HP:0003584)2.00363441
105Abnormality of the corticospinal tract (HP:0002492)2.00096264
106Orthostatic hypotension (HP:0001278)1.96764657
107Exotropia (HP:0000577)1.96326408
108Skin nodule (HP:0200036)1.94916746
109Central scotoma (HP:0000603)1.94439913
110Abdominal distention (HP:0003270)1.94063114
111Abnormality of calcium-phosphate metabolism (HP:0100530)1.92924349
112Decreased circulating renin level (HP:0003351)1.91962732
113Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.91194302
114Aneurysm (HP:0002617)1.91087279
115Bell-shaped thorax (HP:0001591)1.89083157
116Action tremor (HP:0002345)1.88680010
117Abnormality of polysaccharide metabolism (HP:0011012)1.87974884
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87974884
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87974884
120Protruding ear (HP:0000411)1.86262412
121Back pain (HP:0003418)1.84699879
122Abnormality of the labia majora (HP:0012881)1.82522746
123Malignant neoplasm of the central nervous system (HP:0100836)1.82114277
124Dysostosis multiplex (HP:0000943)1.82097440
125Abnormal pancreas size (HP:0012094)1.81907997
126Hypoventilation (HP:0002791)1.81443545
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80335000
128Abnormality of the carotid arteries (HP:0005344)1.79685813
129Hyperkalemia (HP:0002153)1.77479648
130Supranuclear gaze palsy (HP:0000605)1.76604015
131Intention tremor (HP:0002080)1.76589611
132Hypoalphalipoproteinemia (HP:0003233)1.75616469
133Generalized hypotonia (HP:0001290)1.75244757
134Blue irides (HP:0000635)1.75021930
135Weak cry (HP:0001612)1.74057429
136Agitation (HP:0000713)1.74039360
137Postural instability (HP:0002172)1.72424776
138Thoracolumbar scoliosis (HP:0002944)1.72322704
139Renovascular hypertension (HP:0100817)1.71894171
140Decreased lacrimation (HP:0000633)1.71842075
141Upper limb amyotrophy (HP:0009129)1.71677804
142Distal upper limb amyotrophy (HP:0007149)1.71677804
143Cubitus valgus (HP:0002967)1.71671174
144Deep venous thrombosis (HP:0002625)1.71521030
145Dyschromatopsia (HP:0007641)1.71489535
146Clonus (HP:0002169)1.71307513
147Hypopigmentation of the fundus (HP:0007894)1.70564663
148Abnormality of skull ossification (HP:0002703)1.70431400
149Nervous tissue neoplasm (HP:0030060)1.68772860
150Neuroectodermal neoplasm (HP:0030061)1.68772860
151Neuroepithelial neoplasm (HP:0030063)1.68772860
152Hand muscle atrophy (HP:0009130)1.67894450
153Abnormal glucose tolerance (HP:0001952)1.67751696
154Hypokalemia (HP:0002900)1.66655890
155Sensory axonal neuropathy (HP:0003390)1.66484239
156Delayed cranial suture closure (HP:0000270)1.65857994
157Insulin resistance (HP:0000855)1.65491198
158Overlapping toe (HP:0001845)1.64504093
159Ependymoma (HP:0002888)1.63903030
160Choanal atresia (HP:0000453)1.63673493
161Type II diabetes mellitus (HP:0005978)1.63169992
162Enlarged kidneys (HP:0000105)1.61798128
163Chorioretinal atrophy (HP:0000533)1.61366647
164Abnormality of the preputium (HP:0100587)1.61346273
165Type II lissencephaly (HP:0007260)1.61326460
166Glucose intolerance (HP:0000833)1.61218839
167Impaired vibration sensation in the lower limbs (HP:0002166)1.61177856
168Chronic hepatic failure (HP:0100626)1.60929448
169Abnormality of the phalanges of the hallux (HP:0010057)1.59923590
170Underdeveloped supraorbital ridges (HP:0009891)1.59662326
171* Sandal gap (HP:0001852)1.59518754
172Abnormality of potassium homeostasis (HP:0011042)1.58736661
173Fat malabsorption (HP:0002630)1.58660027
174Prolonged QT interval (HP:0001657)1.58541753
175Venous abnormality (HP:0002624)1.58123813
176Global brain atrophy (HP:0002283)1.56982080
177Deep philtrum (HP:0002002)1.56321556
178Congenital glaucoma (HP:0001087)1.56111926
179Leiomyosarcoma (HP:0100243)1.55576920
180Uterine leiomyosarcoma (HP:0002891)1.55576920
181Long toe (HP:0010511)1.55267593
182Gastrointestinal carcinoma (HP:0002672)1.54591499
183Malignant gastrointestinal tract tumors (HP:0006749)1.54591499
184Neoplasm of striated muscle (HP:0009728)1.54334759
185Onion bulb formation (HP:0003383)1.54151070
186Abnormality of monocarboxylic acid metabolism (HP:0010996)1.54074298
187Buphthalmos (HP:0000557)1.53137089
188Neuroendocrine neoplasm (HP:0100634)1.52904938
189Increased CSF protein (HP:0002922)1.52868596
190Breast carcinoma (HP:0003002)1.51832643
191Menstrual irregularities (HP:0000858)1.51787902
192Cone-rod dystrophy (HP:0000548)1.50973371
193Xanthomatosis (HP:0000991)1.50656618
194Small intestinal stenosis (HP:0012848)1.50558249
195Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.50166502
196Neoplasm of the heart (HP:0100544)1.49823283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.98152357
2INSRR4.38243611
3MAP3K104.11547086
4TLK13.97194919
5SRPK13.81424716
6PBK3.64811520
7PRKD33.10102482
8TAOK33.05207394
9FRK2.73893772
10CDC72.62931634
11MAP3K22.48899350
12STK392.40916102
13FGFR22.30632532
14SIK12.09842815
15PDGFRA2.06116130
16PRKCH1.89678086
17TTK1.77102440
18WNK41.75133187
19MET1.74433438
20CAMK1G1.72099867
21NTRK11.70341860
22NTRK31.69741032
23ICK1.69384464
24PLK41.69330816
25TSSK61.68849037
26WNK11.64125284
27TRIB31.59328334
28PTK61.54391224
29PASK1.52950807
30PDK31.51252518
31PDK41.51252518
32CAMK1D1.50337289
33PDK21.47156096
34VRK11.46480092
35EPHB11.45855357
36EPHA31.44939667
37EIF2AK31.43714588
38LATS11.42120733
39SCYL21.39222942
40HIPK21.38887386
41ERN11.37089038
42BRD41.31469170
43CDC42BPA1.23952768
44CLK11.23915348
45PDGFRB1.22681151
46LMTK21.22401900
47CHEK21.20880518
48AKT31.20027540
49EIF2AK11.19836739
50RET1.16941162
51MKNK21.12179881
52NEK61.10373776
53JAK11.09440287
54NME21.05135113
55SGK4941.04884847
56SGK2231.04884847
57MTOR1.03941322
58IRAK11.02999196
59MATK1.00918240
60ATR1.00274715
61STK40.99513196
62RIPK10.99304933
63RPS6KA50.98502575
64ATM0.98085785
65OBSCN0.96579215
66UHMK10.96261340
67CDK60.96119751
68PKN10.95466400
69PAK30.94286587
70SGK30.94268879
71MAPK150.94114044
72BUB10.93766147
73EEF2K0.93086160
74PTK20.93083088
75TYRO30.91713499
76BRSK20.90070646
77PDPK10.89403923
78PHKG20.89361555
79PHKG10.89361555
80NEK10.88769798
81FGFR40.87980323
82MKNK10.86219321
83PDK10.86189815
84PRKAA10.86128239
85FER0.86019233
86AURKB0.84970247
87TTN0.84841486
88PLK10.83403989
89PRKD20.83134579
90DDR20.82435508
91OXSR10.81571589
92CAMK2D0.78861531
93NME10.77754667
94WEE10.77199410
95CHEK10.76971959
96KSR10.76477860
97MAP3K60.76112217
98PIM10.75438160
99ACVR1B0.74280322
100PRKD10.71634568
101KSR20.70511158
102CDK80.69994474
103CDK120.69795518
104CCNB10.68538507
105MAP4K20.67972131
106CASK0.67425416
107GSK3A0.67265460
108SGK20.67260746
109MARK20.65450642
110FLT30.65221078
111ERBB30.65083753
112FGFR30.64582076
113AURKA0.63561596
114CDK40.62812735
115RPS6KB20.61018800
116MAP3K10.60845022
117PAK60.60430789
118DYRK1B0.60284318
119CDK20.60147631
120PRKAA20.59738725
121JAK20.59381823
122MAP3K70.59017007
123STK30.57260768
124PLK30.57188951
125DMPK0.56926035
126CDK50.55235585
127MAP3K40.54984547
128SGK10.54135514
129CAMK2B0.53935793
130CDK70.53231156
131PKN20.52485553
132ITK0.52069664
133NEK90.50899186
134RPS6KB10.50275675
135CDK10.49994716
136CAMKK10.49388436
137MAPK110.49157829
138PRKCE0.48658589
139PRKDC0.48601268
140IRAK20.48356895
141PIK3CA0.47594450
142AKT20.47331682
143ADRBK20.47279674
144RPS6KA30.46550937
145PNCK0.46179618
146CSNK1E0.46062984
147BCKDK0.44891447
148CAMKK20.44828974
149BMX0.44409353
150NTRK20.43190187
151NEK20.43007865
152PRKACG0.41163358
153PRKCQ0.40049055
154FGFR10.39811466
155ERBB20.39499176
156BCR0.37988085
157CAMK2G0.37885924
158MAPK140.37153145
159CSNK1G10.36911316
160IGF1R0.36618091
161RPS6KA20.36528519
162INSR0.36367069
163CSNK1A1L0.34955897
164MAPK100.34908267

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.47048994
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.26889280
3Alcoholism_Homo sapiens_hsa050343.99118658
4Non-homologous end-joining_Homo sapiens_hsa034503.49739849
5Nitrogen metabolism_Homo sapiens_hsa009102.89119700
6Fanconi anemia pathway_Homo sapiens_hsa034602.80374134
7DNA replication_Homo sapiens_hsa030302.51484068
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49500067
9Sulfur metabolism_Homo sapiens_hsa009202.44568511
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.34001487
11Insulin secretion_Homo sapiens_hsa049112.27631067
12Mismatch repair_Homo sapiens_hsa034302.21055750
13Cell cycle_Homo sapiens_hsa041102.19607777
14Thyroid cancer_Homo sapiens_hsa052162.09027351
15Type II diabetes mellitus_Homo sapiens_hsa049302.08778964
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99153882
17RNA transport_Homo sapiens_hsa030131.84440792
18One carbon pool by folate_Homo sapiens_hsa006701.78679402
19Protein export_Homo sapiens_hsa030601.73273193
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.68873030
21Non-small cell lung cancer_Homo sapiens_hsa052231.65428252
22ABC transporters_Homo sapiens_hsa020101.57201443
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.55606767
24Nucleotide excision repair_Homo sapiens_hsa034201.50651396
25Viral carcinogenesis_Homo sapiens_hsa052031.50387147
26mRNA surveillance pathway_Homo sapiens_hsa030151.49117746
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35447629
28Pancreatic secretion_Homo sapiens_hsa049721.29589988
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28468921
30Lysine degradation_Homo sapiens_hsa003101.25338358
31Homologous recombination_Homo sapiens_hsa034401.24167199
32Spliceosome_Homo sapiens_hsa030401.23682285
33Selenocompound metabolism_Homo sapiens_hsa004501.23201003
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22626601
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21810359
36MicroRNAs in cancer_Homo sapiens_hsa052061.20918839
37Glucagon signaling pathway_Homo sapiens_hsa049221.20779075
38Dorso-ventral axis formation_Homo sapiens_hsa043201.18238758
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16038437
40Butanoate metabolism_Homo sapiens_hsa006501.15042514
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12969474
42Fat digestion and absorption_Homo sapiens_hsa049751.12468420
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11969555
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11741294
45Insulin resistance_Homo sapiens_hsa049311.11585420
46Bile secretion_Homo sapiens_hsa049761.11299846
47Propanoate metabolism_Homo sapiens_hsa006401.11091597
48Tryptophan metabolism_Homo sapiens_hsa003801.10969695
49Thyroid hormone synthesis_Homo sapiens_hsa049181.10596222
50Small cell lung cancer_Homo sapiens_hsa052221.09968296
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09243966
52Chronic myeloid leukemia_Homo sapiens_hsa052201.08786193
53Base excision repair_Homo sapiens_hsa034101.08157021
54Cocaine addiction_Homo sapiens_hsa050301.07045492
55Fatty acid metabolism_Homo sapiens_hsa012121.06136102
56Colorectal cancer_Homo sapiens_hsa052101.03618267
57Fatty acid degradation_Homo sapiens_hsa000711.02407309
58N-Glycan biosynthesis_Homo sapiens_hsa005101.01651731
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99590159
60Fatty acid biosynthesis_Homo sapiens_hsa000610.99012653
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98203341
62Vibrio cholerae infection_Homo sapiens_hsa051100.98050376
63Arginine biosynthesis_Homo sapiens_hsa002200.98039879
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96643632
65Adherens junction_Homo sapiens_hsa045200.95862748
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95718350
67Basal transcription factors_Homo sapiens_hsa030220.93339750
68TGF-beta signaling pathway_Homo sapiens_hsa043500.93022740
69Protein digestion and absorption_Homo sapiens_hsa049740.90006354
70ErbB signaling pathway_Homo sapiens_hsa040120.89136494
71Lysosome_Homo sapiens_hsa041420.86889753
72Pancreatic cancer_Homo sapiens_hsa052120.86652435
73Amphetamine addiction_Homo sapiens_hsa050310.86347104
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85701483
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.85295034
76Starch and sucrose metabolism_Homo sapiens_hsa005000.83107200
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81490690
78Choline metabolism in cancer_Homo sapiens_hsa052310.81257561
79Renin secretion_Homo sapiens_hsa049240.80569984
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.80391328
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80319835
82mTOR signaling pathway_Homo sapiens_hsa041500.79862394
83GABAergic synapse_Homo sapiens_hsa047270.78669909
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78536645
85Estrogen signaling pathway_Homo sapiens_hsa049150.78341536
86PPAR signaling pathway_Homo sapiens_hsa033200.77893175
87Cholinergic synapse_Homo sapiens_hsa047250.77773246
88AMPK signaling pathway_Homo sapiens_hsa041520.76109323
89Circadian entrainment_Homo sapiens_hsa047130.75009047
90Inositol phosphate metabolism_Homo sapiens_hsa005620.73582174
91Oocyte meiosis_Homo sapiens_hsa041140.72875516
92Long-term potentiation_Homo sapiens_hsa047200.71388813
93Glycerolipid metabolism_Homo sapiens_hsa005610.71316328
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.71217543
95p53 signaling pathway_Homo sapiens_hsa041150.71148282
96Purine metabolism_Homo sapiens_hsa002300.68965571
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67776133
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67632328
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67314046
100Salivary secretion_Homo sapiens_hsa049700.66248841
101Dopaminergic synapse_Homo sapiens_hsa047280.66082733
102Gastric acid secretion_Homo sapiens_hsa049710.66015548
103Endometrial cancer_Homo sapiens_hsa052130.65581146
104Insulin signaling pathway_Homo sapiens_hsa049100.65200333
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64631953
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63825363
107Nicotine addiction_Homo sapiens_hsa050330.62262770
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.61159804
109Taste transduction_Homo sapiens_hsa047420.60534933
110Pyrimidine metabolism_Homo sapiens_hsa002400.59853162
111cAMP signaling pathway_Homo sapiens_hsa040240.59703090
112Prion diseases_Homo sapiens_hsa050200.59211904
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.58483965
114RNA degradation_Homo sapiens_hsa030180.57903098
115Glutamatergic synapse_Homo sapiens_hsa047240.57634689
116Morphine addiction_Homo sapiens_hsa050320.57444895
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55275756
118Melanoma_Homo sapiens_hsa052180.55028680
119Fatty acid elongation_Homo sapiens_hsa000620.54822102
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54734184
121Circadian rhythm_Homo sapiens_hsa047100.53583585
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52894946
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52789108
124Prolactin signaling pathway_Homo sapiens_hsa049170.51198078
125Dilated cardiomyopathy_Homo sapiens_hsa054140.50921255
126Biosynthesis of amino acids_Homo sapiens_hsa012300.50738883
127Steroid biosynthesis_Homo sapiens_hsa001000.50311823
128Pyruvate metabolism_Homo sapiens_hsa006200.49478816
129Complement and coagulation cascades_Homo sapiens_hsa046100.49241305
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.48136900
131Caffeine metabolism_Homo sapiens_hsa002320.47611154
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47199889
133Prostate cancer_Homo sapiens_hsa052150.47030959
134Synaptic vesicle cycle_Homo sapiens_hsa047210.46193651
135ECM-receptor interaction_Homo sapiens_hsa045120.46020584
136Focal adhesion_Homo sapiens_hsa045100.45859091
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45766835
138Histidine metabolism_Homo sapiens_hsa003400.45550871
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44183066
140Type I diabetes mellitus_Homo sapiens_hsa049400.44065094
141Glioma_Homo sapiens_hsa052140.43968069
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.43598724
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43326833
144Sphingolipid metabolism_Homo sapiens_hsa006000.43206453
145Pathways in cancer_Homo sapiens_hsa052000.41674426
146Gap junction_Homo sapiens_hsa045400.41642641
147Hedgehog signaling pathway_Homo sapiens_hsa043400.40781097
148Peroxisome_Homo sapiens_hsa041460.40407224
149FoxO signaling pathway_Homo sapiens_hsa040680.39779110
150Proteoglycans in cancer_Homo sapiens_hsa052050.39082314
151Long-term depression_Homo sapiens_hsa047300.37716094
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.35867308
153Hippo signaling pathway_Homo sapiens_hsa043900.35415149
154Tight junction_Homo sapiens_hsa045300.34348879
155Calcium signaling pathway_Homo sapiens_hsa040200.33624172
156Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32953726
157RNA polymerase_Homo sapiens_hsa030200.32517595
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30980740
159HIF-1 signaling pathway_Homo sapiens_hsa040660.29338811
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.27967834

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