NBEAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.26703030
2translational termination (GO:0006415)8.97323181
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.85260635
4ribosomal small subunit assembly (GO:0000028)7.84642697
5cotranslational protein targeting to membrane (GO:0006613)7.78485468
6protein targeting to ER (GO:0045047)7.65169264
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.38110035
8translational elongation (GO:0006414)7.26893935
9protein localization to endoplasmic reticulum (GO:0070972)7.07262127
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.94615177
11cellular protein complex disassembly (GO:0043624)6.89185550
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.63394065
13viral life cycle (GO:0019058)6.57565366
14energy coupled proton transport, down electrochemical gradient (GO:0015985)6.21843522
15ATP synthesis coupled proton transport (GO:0015986)6.21843522
16maturation of SSU-rRNA (GO:0030490)6.17212827
17translational initiation (GO:0006413)6.02674982
18protein complex disassembly (GO:0043241)5.76459675
19ribosomal small subunit biogenesis (GO:0042274)5.54923599
20macromolecular complex disassembly (GO:0032984)5.43834613
21protein targeting to membrane (GO:0006612)5.13059218
22ribosomal large subunit biogenesis (GO:0042273)4.94538583
23sequestering of actin monomers (GO:0042989)4.86419502
24nuclear-transcribed mRNA catabolic process (GO:0000956)4.71543535
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.61596423
26mRNA catabolic process (GO:0006402)4.47768257
27inner mitochondrial membrane organization (GO:0007007)4.34466755
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31870549
29respiratory electron transport chain (GO:0022904)4.23631987
30electron transport chain (GO:0022900)4.19269348
31translation (GO:0006412)4.18060901
32positive regulation of gastrulation (GO:2000543)4.06035417
33RNA catabolic process (GO:0006401)3.90879491
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89932858
35midbrain development (GO:0030901)3.69079929
36protein complex biogenesis (GO:0070271)3.58538930
37epithelial cilium movement (GO:0003351)3.43494820
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43376492
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.43376492
40NADH dehydrogenase complex assembly (GO:0010257)3.43376492
41establishment of protein localization to membrane (GO:0090150)3.43278493
42retina vasculature morphogenesis in camera-type eye (GO:0061299)3.40012976
43mitochondrial respiratory chain complex assembly (GO:0033108)3.36287816
44lateral sprouting from an epithelium (GO:0060601)3.35406757
45primitive streak formation (GO:0090009)3.34366371
46otic vesicle formation (GO:0030916)3.32971526
47neuron fate determination (GO:0048664)3.29745976
48protein neddylation (GO:0045116)3.17815708
49protein targeting (GO:0006605)3.13045801
50kidney morphogenesis (GO:0060993)3.11701801
51ATP biosynthetic process (GO:0006754)3.09707786
52establishment of protein localization to organelle (GO:0072594)3.08017550
53hydrogen ion transmembrane transport (GO:1902600)3.07840237
54thalamus development (GO:0021794)3.00381151
55glomerulus development (GO:0032835)2.96479285
56vascular endothelial growth factor signaling pathway (GO:0038084)2.94546943
57somite rostral/caudal axis specification (GO:0032525)2.93952174
58urogenital system development (GO:0001655)2.93236635
59lymph vessel development (GO:0001945)2.82414794
60negative regulation of DNA repair (GO:0045738)2.81526415
61regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78510208
62fibroblast migration (GO:0010761)2.77681622
63dopaminergic neuron differentiation (GO:0071542)2.77025823
64proton transport (GO:0015992)2.75920458
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75667287
66limb bud formation (GO:0060174)2.75596723
67smooth muscle tissue development (GO:0048745)2.75514178
68spliceosomal complex assembly (GO:0000245)2.75191878
69intraciliary transport (GO:0042073)2.74316442
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70897811
71regulation of protein polyubiquitination (GO:1902914)2.70458821
72protein localization to membrane (GO:0072657)2.70129914
73chromatin remodeling at centromere (GO:0031055)2.69846154
74hydrogen transport (GO:0006818)2.69789746
75embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69647415
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67242422
77cilium movement (GO:0003341)2.67068561
78surfactant homeostasis (GO:0043129)2.66735524
79CENP-A containing nucleosome assembly (GO:0034080)2.65701782
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62428022
81positive regulation of smooth muscle cell migration (GO:0014911)2.62114574
82negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.62051634
83behavioral response to nicotine (GO:0035095)2.61004637
84signal peptide processing (GO:0006465)2.60796268
85chaperone-mediated protein transport (GO:0072321)2.60743603
86positive regulation of embryonic development (GO:0040019)2.59776450
87cell adhesion mediated by integrin (GO:0033627)2.58774509
88regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58583115
89interkinetic nuclear migration (GO:0022027)2.58346521
90polyol transport (GO:0015791)2.57776784
91intracellular protein transmembrane import (GO:0044743)2.56161210
92somite development (GO:0061053)2.56061160
93positive regulation of p38MAPK cascade (GO:1900745)2.56027544
94cytoplasmic mRNA processing body assembly (GO:0033962)2.54757860
95platelet-derived growth factor receptor signaling pathway (GO:0048008)2.54507972
96platelet dense granule organization (GO:0060155)2.53683007
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.53062062
98termination of RNA polymerase III transcription (GO:0006386)2.53062062
99regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52853351
100centriole replication (GO:0007099)2.52583853
101hemidesmosome assembly (GO:0031581)2.52290500
102cellular component biogenesis (GO:0044085)2.51765863
103glomerular visceral epithelial cell development (GO:0072015)2.51538052
104nonmotile primary cilium assembly (GO:0035058)2.51190958
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50303338
106photoreceptor cell differentiation (GO:0046530)2.49320167
107eye photoreceptor cell differentiation (GO:0001754)2.49320167
108import into cell (GO:0098657)2.47969724
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47001490
110artery development (GO:0060840)2.46549676
111regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.46455126
112spliceosomal snRNP assembly (GO:0000387)2.45159509
113ribonucleoprotein complex biogenesis (GO:0022613)2.42956462
114protein-cofactor linkage (GO:0018065)2.42051496
115glomerular basement membrane development (GO:0032836)2.41478811
116embryonic camera-type eye morphogenesis (GO:0048596)2.41446183
117early endosome to late endosome transport (GO:0045022)2.41062873
118regulation of sequestering of triglyceride (GO:0010889)2.40380127
119adult feeding behavior (GO:0008343)2.39489575
120retinal ganglion cell axon guidance (GO:0031290)2.38154539
121regulation of mesenchymal cell apoptotic process (GO:2001053)2.38146895
122protein localization to organelle (GO:0033365)2.38133755
123regulation of hexokinase activity (GO:1903299)2.37138643
124regulation of glucokinase activity (GO:0033131)2.37138643
125negative regulation of Rho protein signal transduction (GO:0035024)2.35603947
126nephron tubule morphogenesis (GO:0072078)2.34451740
127nephron epithelium morphogenesis (GO:0072088)2.34451740
128phospholipid homeostasis (GO:0055091)2.33384906
129endothelial cell morphogenesis (GO:0001886)2.31987657
130positive regulation of cellular amide metabolic process (GO:0034250)2.31721052
131determination of left/right symmetry (GO:0007368)2.30814715
132mammary gland development (GO:0030879)2.29413466
133prostate gland growth (GO:0060736)2.28962508
134morphogenesis of an epithelial sheet (GO:0002011)2.26974514
135lymphangiogenesis (GO:0001946)2.26674818
136wound healing, spreading of epidermal cells (GO:0035313)2.26162171
137mesenchymal cell differentiation (GO:0048762)2.25998741
138fatty acid transmembrane transport (GO:1902001)2.25957411
139chemical homeostasis within a tissue (GO:0048875)2.25134805
140substrate-dependent cell migration (GO:0006929)2.24243299
141ganglion development (GO:0061548)2.24192549
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.23807963
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23120527
144relaxation of cardiac muscle (GO:0055119)2.21248914
145intracellular lipid transport (GO:0032365)2.21086025
146glomerular filtration (GO:0003094)2.20061034
147regulation of vasculogenesis (GO:2001212)2.18513789
148renal filtration (GO:0097205)2.17797151
149lung alveolus development (GO:0048286)2.17627650
150Sertoli cell development (GO:0060009)2.14735979
151histone H3-K36 demethylation (GO:0070544)2.14402916
152growth hormone receptor signaling pathway (GO:0060396)2.13342091
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.12963453
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.12913161
155glomerular epithelial cell development (GO:0072310)2.12707922
156negative regulation of translation, ncRNA-mediated (GO:0040033)2.12203832
157regulation of translation, ncRNA-mediated (GO:0045974)2.12203832
158negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.12203832
159endocardial cushion morphogenesis (GO:0003203)2.11847588
160negative regulation of protein autophosphorylation (GO:0031953)2.10810964
161collagen fibril organization (GO:0030199)2.10360775
162positive regulation of muscle hypertrophy (GO:0014742)2.09495347
163positive regulation of cardiac muscle hypertrophy (GO:0010613)2.09495347
164negative regulation of keratinocyte proliferation (GO:0010839)2.07165864
165myelination in peripheral nervous system (GO:0022011)2.06992885
166peripheral nervous system axon ensheathment (GO:0032292)2.06992885
167ovulation from ovarian follicle (GO:0001542)2.06476325
168appendage development (GO:0048736)2.06458291
169limb development (GO:0060173)2.06458291
170carnitine shuttle (GO:0006853)2.05940568
171response to hepatocyte growth factor (GO:0035728)2.05607549
172cellular response to hepatocyte growth factor stimulus (GO:0035729)2.05607549
173sequestering of extracellular ligand from receptor (GO:0035581)2.04556916
174positive regulation of fatty acid oxidation (GO:0046321)2.03385278
175iron ion import (GO:0097286)2.03303671
176regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.02217479
177chondrocyte development (GO:0002063)2.01858288
178coronary vasculature morphogenesis (GO:0060977)2.00330633
179positive regulation of mesenchymal cell proliferation (GO:0002053)1.99637915
180regulation of mesenchymal cell proliferation (GO:0010464)1.99573885
181positive regulation of NIK/NF-kappaB signaling (GO:1901224)1.99225586
182heart valve morphogenesis (GO:0003179)1.99094772
183response to lipoprotein particle (GO:0055094)1.98061286
184positive regulation of protein kinase C signaling (GO:0090037)1.97944006
185regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.97518256
186negative regulation of systemic arterial blood pressure (GO:0003085)1.97144940
187endothelium development (GO:0003158)1.95326817
188positive regulation of cardiac muscle cell differentiation (GO:2000727)1.94477612
189radial glial cell differentiation (GO:0060019)1.93506337
190negative regulation of myoblast differentiation (GO:0045662)1.93314875
191regulation of endothelial cell differentiation (GO:0045601)1.92409879
192negative regulation of lipid storage (GO:0010888)1.91439097
193regulation of NIK/NF-kappaB signaling (GO:1901222)1.90935665
194negative regulation of neurotransmitter secretion (GO:0046929)1.90480909
195replicative senescence (GO:0090399)1.90201552
196mesenchyme morphogenesis (GO:0072132)1.89851641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45872359
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.21242711
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.20694433
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77846545
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69833672
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59905123
7* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.58031741
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55325599
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.49813901
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44930638
11GBX2_23144817_ChIP-Seq_PC3_Human2.42935359
12ELK1_19687146_ChIP-ChIP_HELA_Human2.39978478
13ZNF274_21170338_ChIP-Seq_K562_Hela2.39729029
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38701612
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.29040338
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28286967
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.17789465
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16347858
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.12028864
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.03404034
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03241034
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01065971
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01052753
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95429298
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86042944
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85056246
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.81926725
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77609025
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76736567
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76736567
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.75793791
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75770840
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71500365
34MYC_18940864_ChIP-ChIP_HL60_Human1.67627491
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65803448
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64061828
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63507965
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62839274
39AHR_22903824_ChIP-Seq_MCF-7_Human1.62475211
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.62465135
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62313884
42TP53_16413492_ChIP-PET_HCT116_Human1.61261111
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60985150
44* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59321496
45* FLI1_27457419_Chip-Seq_LIVER_Mouse1.59111219
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58987772
47CJUN_26792858_Chip-Seq_BT549_Human1.58561230
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57290203
49* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57117131
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54325414
51GATA1_22025678_ChIP-Seq_K562_Human1.53410149
52* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52885342
53SMAD4_21799915_ChIP-Seq_A2780_Human1.51709688
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51399122
55TAF15_26573619_Chip-Seq_HEK293_Human1.50893447
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49936658
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49842596
58TP53_18474530_ChIP-ChIP_U2OS_Human1.49113423
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47770710
60P300_19829295_ChIP-Seq_ESCs_Human1.47337545
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47209319
62* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46920456
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.45064080
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.44181838
65VDR_23849224_ChIP-Seq_CD4+_Human1.43637195
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42336080
67BCAT_22108803_ChIP-Seq_LS180_Human1.42002681
68* NANOG_18555785_Chip-Seq_ESCs_Mouse1.41825846
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.41727524
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41344379
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.39792785
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.39713599
73IGF1R_20145208_ChIP-Seq_DFB_Human1.39302882
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38534178
75* EZH2_27294783_Chip-Seq_NPCs_Mouse1.38457662
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.38447401
77ER_23166858_ChIP-Seq_MCF-7_Human1.38394991
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.37333921
79* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37060689
80* E2F1_18555785_Chip-Seq_ESCs_Mouse1.36683071
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36391825
82* NFE2_27457419_Chip-Seq_LIVER_Mouse1.36036189
83AR_21572438_ChIP-Seq_LNCaP_Human1.33509206
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.33326163
85STAT3_23295773_ChIP-Seq_U87_Human1.33052727
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32494267
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32494267
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29870750
89TTF2_22483619_ChIP-Seq_HELA_Human1.28494515
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27668238
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26600139
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26532966
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.25789139
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25321944
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.22630867
96* P53_22387025_ChIP-Seq_ESCs_Mouse1.22484279
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21605050
98* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21317756
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20462209
100RNF2_27304074_Chip-Seq_NSC_Mouse1.20347517
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18262856
102* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17243502
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17090678
104* TCF4_23295773_ChIP-Seq_U87_Human1.15605752
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15083752
106ELK1_22589737_ChIP-Seq_MCF10A_Human1.14653244
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14260709
108TCF4_22108803_ChIP-Seq_LS180_Human1.13926661
109EZH2_22144423_ChIP-Seq_EOC_Human1.13275642
110* STAT3_18555785_Chip-Seq_ESCs_Mouse1.13150020
111RXR_22108803_ChIP-Seq_LS180_Human1.12462336
112FUS_26573619_Chip-Seq_HEK293_Human1.12343182
113CBP_20019798_ChIP-Seq_JUKART_Human1.11984167
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11984167
115MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11602628
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11089195
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.11003167
118VDR_22108803_ChIP-Seq_LS180_Human1.10578073
119TP53_22573176_ChIP-Seq_HFKS_Human1.10126646
120AR_25329375_ChIP-Seq_VCAP_Human1.08299585
121EWS_26573619_Chip-Seq_HEK293_Human1.08113114
122SOX2_20726797_ChIP-Seq_SW620_Human1.08056921
123* P300_18555785_Chip-Seq_ESCs_Mouse1.07943718
124* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07786401
125* OCT4_18555785_Chip-Seq_ESCs_Mouse1.07339135
126NANOG_19829295_ChIP-Seq_ESCs_Human1.07215186
127SOX2_19829295_ChIP-Seq_ESCs_Human1.07215186
128RUNX2_22187159_ChIP-Seq_PCA_Human1.07054318
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06780350
130SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06419202
131* SOX2_18555785_Chip-Seq_ESCs_Mouse1.06411000
132FOXO3_23340844_ChIP-Seq_DLD1_Human1.05263970
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05171891
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04111566
135EED_16625203_ChIP-ChIP_MESCs_Mouse1.04017697
136* NMYC_18555785_Chip-Seq_ESCs_Mouse1.03567689
137CDX2_22108803_ChIP-Seq_LS180_Human1.03196282
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02335623
139TP63_23658742_ChIP-Seq_EP156T_Human1.01332500
140* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01125505
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99125875
142* PU1_27457419_Chip-Seq_LIVER_Mouse0.98999053
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98579561
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98543348
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97532419
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97362234
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.97342811
148VDR_24787735_ChIP-Seq_THP-1_Human0.96963356
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.95611040
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95297895
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.95297895
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95049332
153HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94631192
154LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92078212
155FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89698833
156KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89108811
157FOXP3_21729870_ChIP-Seq_TREG_Human0.88810558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.51905507
2MP0008438_abnormal_cutaneous_collagen4.30547028
3MP0000569_abnormal_digit_pigmentation4.27042055
4MP0003136_yellow_coat_color4.05890916
5MP0010030_abnormal_orbit_morphology3.73500290
6MP0002938_white_spotting3.41800043
7MP0004272_abnormal_basement_membrane3.20133808
8MP0005503_abnormal_tendon_morphology2.86973167
9MP0003283_abnormal_digestive_organ2.82534140
10MP0005171_absent_coat_pigmentation2.80875713
11MP0006292_abnormal_olfactory_placode2.64782817
12MP0010368_abnormal_lymphatic_system2.63602374
13MP0005275_abnormal_skin_tensile2.62772216
14MP0003941_abnormal_skin_development2.62346136
15MP0001879_abnormal_lymphatic_vessel2.52987878
16MP0009780_abnormal_chondrocyte_physiolo2.48975024
17MP0003890_abnormal_embryonic-extraembry2.43833799
18MP0003045_fibrosis2.41522833
19MP0009384_cardiac_valve_regurgitation2.30389866
20MP0002009_preneoplasia2.25838438
21MP0001293_anophthalmia2.13905051
22MP0002234_abnormal_pharynx_morphology2.07743868
23MP0003950_abnormal_plasma_membrane2.05640392
24MP0006072_abnormal_retinal_apoptosis2.03478427
25MP0001661_extended_life_span2.00146708
26MP0003252_abnormal_bile_duct1.99858092
27MP0005670_abnormal_white_adipose1.93760310
28MP0003011_delayed_dark_adaptation1.92419249
29MP0002277_abnormal_respiratory_mucosa1.92105970
30MP0010386_abnormal_urinary_bladder1.80820381
31MP0002254_reproductive_system_inflammat1.80019611
32MP0008995_early_reproductive_senescence1.78779335
33MP0002168_other_aberrant_phenotype1.65654989
34MP0001958_emphysema1.65171275
35MP0002108_abnormal_muscle_morphology1.64436092
36MP0002102_abnormal_ear_morphology1.58506203
37MP0001299_abnormal_eye_distance/1.57501840
38MP0005408_hypopigmentation1.54779979
39MP0000631_abnormal_neuroendocrine_gland1.53927513
40MP0004142_abnormal_muscle_tone1.48723533
41MP0010678_abnormal_skin_adnexa1.48001392
42MP0002282_abnormal_trachea_morphology1.47170451
43MP0004133_heterotaxia1.46290226
44MP0001286_abnormal_eye_development1.45692699
45MP0003828_pulmonary_edema1.45631584
46MP0001346_abnormal_lacrimal_gland1.43026542
47MP0005666_abnormal_adipose_tissue1.42908359
48MP0000383_abnormal_hair_follicle1.42837849
49MP0003091_abnormal_cell_migration1.41218591
50MP0002638_abnormal_pupillary_reflex1.40883055
51MP0002295_abnormal_pulmonary_circulatio1.39206983
52MP0002697_abnormal_eye_size1.38625770
53MP0002060_abnormal_skin_morphology1.38605269
54MP0001485_abnormal_pinna_reflex1.38494835
55MP0005253_abnormal_eye_physiology1.38218361
56MP0002166_altered_tumor_susceptibility1.37749589
57MP0004484_altered_response_of1.37722239
58MP0003279_aneurysm1.34379542
59MP0005084_abnormal_gallbladder_morpholo1.33471310
60MP0004130_abnormal_muscle_cell1.32794561
61MP0009697_abnormal_copulation1.31541803
62MP0000537_abnormal_urethra_morphology1.31070420
63MP0001529_abnormal_vocalization1.29855454
64MP0003938_abnormal_ear_development1.29162309
65MP0000767_abnormal_smooth_muscle1.26945554
66MP0003119_abnormal_digestive_system1.26331729
67MP0005248_abnormal_Harderian_gland1.23941240
68MP0002095_abnormal_skin_pigmentation1.22991865
69MP0002928_abnormal_bile_duct1.22767847
70MP0003937_abnormal_limbs/digits/tail_de1.22521740
71MP0003300_gastrointestinal_ulcer1.21505842
72MP0003724_increased_susceptibility_to1.20639671
73MP0004134_abnormal_chest_morphology1.20098741
74MP0000427_abnormal_hair_cycle1.19660145
75MP0000566_synostosis1.19651133
76MP0005551_abnormal_eye_electrophysiolog1.19575297
77MP0003315_abnormal_perineum_morphology1.14602894
78MP0002972_abnormal_cardiac_muscle1.14002480
79MP0005391_vision/eye_phenotype1.13619166
80MP0000516_abnormal_urinary_system1.13467349
81MP0005367_renal/urinary_system_phenotyp1.13467349
82MP0008961_abnormal_basal_metabolism1.12214134
83MP0002233_abnormal_nose_morphology1.12121897
84MP0004885_abnormal_endolymph1.11971589
85MP0000026_abnormal_inner_ear1.11117339
86MP0005365_abnormal_bile_salt1.10850985
87MP0000538_abnormal_urinary_bladder1.10842909
88MP0006138_congestive_heart_failure1.10501004
89MP0000647_abnormal_sebaceous_gland1.10443726
90MP0005174_abnormal_tail_pigmentation1.09706245
91MP0000778_abnormal_nervous_system1.09340458
92MP0001986_abnormal_taste_sensitivity1.09169718
93MP0003566_abnormal_cell_adhesion1.06235395
94MP0002006_tumorigenesis1.05663845
95MP0003718_maternal_effect1.05016425
96MP0002751_abnormal_autonomic_nervous1.04962451
97MP0005623_abnormal_meninges_morphology1.04339494
98MP0002896_abnormal_bone_mineralization1.04250285
99MP0001188_hyperpigmentation1.03811207
100MP0004145_abnormal_muscle_electrophysio1.02430067
101MP0005187_abnormal_penis_morphology1.02214804
102MP0001984_abnormal_olfaction1.00370394
103MP0009250_abnormal_appendicular_skeleto1.00245037
104MP0010234_abnormal_vibrissa_follicle1.00123109
105MP0003690_abnormal_glial_cell0.98744627
106MP0000579_abnormal_nail_morphology0.98733944
107MP0000013_abnormal_adipose_tissue0.98556190
108MP0001177_atelectasis0.98421537
109MP0004215_abnormal_myocardial_fiber0.98187798
110MP0008775_abnormal_heart_ventricle0.97156636
111MP0003195_calcinosis0.96985017
112MP0000462_abnormal_digestive_system0.96307877
113MP0008877_abnormal_DNA_methylation0.96121576
114MP0003878_abnormal_ear_physiology0.95222229
115MP0005377_hearing/vestibular/ear_phenot0.95222229
116MP0001324_abnormal_eye_pigmentation0.94663075
117MP0000049_abnormal_middle_ear0.94386646
118MP0005164_abnormal_response_to0.93246020
119MP0002133_abnormal_respiratory_system0.92696275
120MP0005388_respiratory_system_phenotype0.92696275
121MP0000163_abnormal_cartilage_morphology0.91646279
122MP0003880_abnormal_central_pattern0.91346565
123MP0005508_abnormal_skeleton_morphology0.91205645
124MP0005646_abnormal_pituitary_gland0.90793382
125MP0005257_abnormal_intraocular_pressure0.90645908
126MP0008058_abnormal_DNA_repair0.90334816
127MP0003755_abnormal_palate_morphology0.90248038
128MP0008789_abnormal_olfactory_epithelium0.90104074
129MP0005620_abnormal_muscle_contractility0.88223401
130MP0004084_abnormal_cardiac_muscle0.88189499
131MP0005195_abnormal_posterior_eye0.87903858
132MP0005375_adipose_tissue_phenotype0.87341226
133MP0000372_irregular_coat_pigmentation0.86040486
134MP0004742_abnormal_vestibular_system0.85987588
135MP0000015_abnormal_ear_pigmentation0.85066457
136MP0005379_endocrine/exocrine_gland_phen0.84763206
137MP0002837_dystrophic_cardiac_calcinosis0.83256860
138MP0002998_abnormal_bone_remodeling0.83238451
139MP0005085_abnormal_gallbladder_physiolo0.83064359
140MP0002115_abnormal_skeleton_extremities0.82923232
141MP0005595_abnormal_vascular_smooth0.82309496
142MP0002138_abnormal_hepatobiliary_system0.81276993
143MP0005075_abnormal_melanosome_morpholog0.80988919
144MP0003186_abnormal_redox_activity0.80157491
145MP0000762_abnormal_tongue_morphology0.77757335
146MP0004883_abnormal_blood_vessel0.77157852
147MP0002109_abnormal_limb_morphology0.77128585
148MP0000371_diluted_coat_color0.76782764
149MP0010630_abnormal_cardiac_muscle0.76041446
150MP0003935_abnormal_craniofacial_develop0.75898525
151MP0001270_distended_abdomen0.75421016
152MP0000003_abnormal_adipose_tissue0.75187842
153MP0003868_abnormal_feces_composition0.74779849
154MP0002736_abnormal_nociception_after0.74735815
155MP0002177_abnormal_outer_ear0.73854439
156MP0002971_abnormal_brown_adipose0.73191294
157MP0004264_abnormal_extraembryonic_tissu0.72915044
158MP0004185_abnormal_adipocyte_glucose0.71935611
159MP0008875_abnormal_xenobiotic_pharmacok0.71666951
160MP0004036_abnormal_muscle_relaxation0.71524574
161MP0000230_abnormal_systemic_arterial0.71498868
162MP0002098_abnormal_vibrissa_morphology0.71381479
163MP0002092_abnormal_eye_morphology0.71236190
164MP0005409_darkened_coat_color0.70512126
165MP0006276_abnormal_autonomic_nervous0.69699145
166MP0002210_abnormal_sex_determination0.67271704
167MP0005394_taste/olfaction_phenotype0.66600192
168MP0005499_abnormal_olfactory_system0.66600192
169MP0001666_abnormal_nutrient_absorption0.66423897
170MP0002160_abnormal_reproductive_system0.65976570
171MP0003567_abnormal_fetal_cardiomyocyte0.63507560
172MP0002653_abnormal_ependyma_morphology0.63250757

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.69788651
2Abnormal number of erythroid precursors (HP:0012131)4.93914524
3Abnormality of cells of the erythroid lineage (HP:0012130)4.88209942
4Congenital, generalized hypertrichosis (HP:0004540)4.57198279
5Macrocytic anemia (HP:0001972)4.17901103
6Abnormality of the ischium (HP:0003174)3.85020923
7Increased hepatocellular lipid droplets (HP:0006565)3.78274723
8Pancreatic cysts (HP:0001737)3.69219949
9Acute necrotizing encephalopathy (HP:0006965)3.60099892
10Hypoplastic ischia (HP:0003175)3.59070900
11Right ventricular cardiomyopathy (HP:0011663)3.39759877
12Mitochondrial inheritance (HP:0001427)3.38753059
13Lipid accumulation in hepatocytes (HP:0006561)3.36597947
14Abnormality of the nasal septum (HP:0000419)3.30928519
15Septo-optic dysplasia (HP:0100842)3.20020696
16Submucous cleft hard palate (HP:0000176)3.19614622
17Pancreatic fibrosis (HP:0100732)3.17526004
18Acute encephalopathy (HP:0006846)3.09027879
19Colon cancer (HP:0003003)3.05113245
20Progressive macrocephaly (HP:0004481)3.01205218
21True hermaphroditism (HP:0010459)3.01093155
22Abnormal mitochondria in muscle tissue (HP:0008316)2.97035269
23Concave nail (HP:0001598)2.86302793
24Pallor (HP:0000980)2.83063154
25Increased CSF lactate (HP:0002490)2.82444375
26Abnormality of midbrain morphology (HP:0002418)2.80278805
27Molar tooth sign on MRI (HP:0002419)2.80278805
28Nephronophthisis (HP:0000090)2.77086357
29Pulmonary artery stenosis (HP:0004415)2.76823534
30Abnormality of incisor morphology (HP:0011063)2.73245487
31Broad metatarsal (HP:0001783)2.66113947
32Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.64493389
33Aortic dissection (HP:0002647)2.64462216
34Renal Fanconi syndrome (HP:0001994)2.64403676
35Hepatic necrosis (HP:0002605)2.64118034
36Type II lissencephaly (HP:0007260)2.63632193
37Distal lower limb muscle weakness (HP:0009053)2.62586550
38Abnormality of the parietal bone (HP:0002696)2.59726783
39Partial duplication of thumb phalanx (HP:0009944)2.59619745
40Abnormality of the renal medulla (HP:0100957)2.58751934
413-Methylglutaconic aciduria (HP:0003535)2.58074332
42Hepatocellular necrosis (HP:0001404)2.56149037
43Partial duplication of the phalanx of hand (HP:0009999)2.55703024
44Thick nail (HP:0001805)2.53493670
45Bell-shaped thorax (HP:0001591)2.45923503
46Bilateral microphthalmos (HP:0007633)2.43723057
47Abnormality of the frontal sinuses (HP:0002687)2.43464383
48Medial flaring of the eyebrow (HP:0010747)2.42746428
49Hypoplasia of the iris (HP:0007676)2.41761426
50Insulin-resistant diabetes mellitus (HP:0000831)2.41650021
51Triphalangeal thumb (HP:0001199)2.40631798
52Maternal diabetes (HP:0009800)2.38951523
53Subacute progressive viral hepatitis (HP:0006572)2.37883225
54Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.36540419
55Stomach cancer (HP:0012126)2.32635779
56Abnormality of the pons (HP:0007361)2.31496445
57Aortic aneurysm (HP:0004942)2.31043334
58Vascular tortuosity (HP:0004948)2.30540706
59Esophageal atresia (HP:0002032)2.29170696
60Limited hip movement (HP:0008800)2.28791069
61Hematochezia (HP:0002573)2.28249332
62Atrophic scars (HP:0001075)2.27497408
63Optic nerve hypoplasia (HP:0000609)2.26611382
64Cerebral edema (HP:0002181)2.24993363
65Exertional dyspnea (HP:0002875)2.24126327
66Stenosis of the external auditory canal (HP:0000402)2.23874335
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23519764
68Absent septum pellucidum (HP:0001331)2.22500626
69Portal hypertension (HP:0001409)2.21797766
70Woolly hair (HP:0002224)2.21772272
71Arterial tortuosity (HP:0005116)2.21699333
72Duplicated collecting system (HP:0000081)2.20467646
73Hypoplasia of the pons (HP:0012110)2.19890487
74Chronic hepatic failure (HP:0100626)2.17855573
75Anophthalmia (HP:0000528)2.14303188
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14160477
77Absent frontal sinuses (HP:0002688)2.13727900
78Hypoglycemic seizures (HP:0002173)2.13363626
79Cystic liver disease (HP:0006706)2.12595094
80Cardiovascular calcification (HP:0011915)2.11950974
81Abnormality of urine glucose concentration (HP:0011016)2.11425998
82Glycosuria (HP:0003076)2.11425998
83Gastrointestinal atresia (HP:0002589)2.09995152
84Duplication of thumb phalanx (HP:0009942)2.09872597
85Renal cortical cysts (HP:0000803)2.09587122
86Cerebellar dysplasia (HP:0007033)2.09485918
87Midline defect of the nose (HP:0004122)2.08323134
88Hyperglycemia (HP:0003074)2.08105914
89Aplasia cutis congenita (HP:0001057)2.08080362
90Esophageal varix (HP:0002040)2.06583525
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.06313882
92Osteolytic defects of the hand bones (HP:0009699)2.06313882
93Abnormality of the hepatic vasculature (HP:0006707)2.06138806
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.05906463
95Abnormality of renal resorption (HP:0011038)2.03803477
96Tubular atrophy (HP:0000092)2.03279576
97Hyporeflexia of lower limbs (HP:0002600)2.02999592
98Abnormality of the renal collecting system (HP:0004742)2.02401968
99Calf muscle hypertrophy (HP:0008981)2.01540071
100Hypoglycemic coma (HP:0001325)2.01036220
101Generalized aminoaciduria (HP:0002909)2.00209636
102Fibular hypoplasia (HP:0003038)1.99260287
103Cone-rod dystrophy (HP:0000548)1.98037063
104Optic disc pallor (HP:0000543)1.98015397
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.97960728
106Genital tract atresia (HP:0001827)1.96929506
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96689328
108Vaginal atresia (HP:0000148)1.95517276
109Abnormal ciliary motility (HP:0012262)1.93425703
110Hydroxyprolinuria (HP:0003080)1.93366796
111Abnormality of proline metabolism (HP:0010907)1.93366796
112Short hallux (HP:0010109)1.93044699
113Sclerocornea (HP:0000647)1.91809216
114Hypoalphalipoproteinemia (HP:0003233)1.91680070
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91429849
116Premature rupture of membranes (HP:0001788)1.91395067
117Abnormality of the septum pellucidum (HP:0007375)1.90864135
118Abnormality of the labia majora (HP:0012881)1.90707507
119Infantile muscular hypotonia (HP:0008947)1.90470344
120Increased connective tissue (HP:0009025)1.89758900
121Absent thumb (HP:0009777)1.89400950
122Tubulointerstitial nephritis (HP:0001970)1.88345706
123Prostate neoplasm (HP:0100787)1.87497757
124Depressed nasal ridge (HP:0000457)1.87211408
125Conjugated hyperbilirubinemia (HP:0002908)1.86252228
126Long foot (HP:0001833)1.85923542
127Abnormality of the renal cortex (HP:0011035)1.85834818
128Meckel diverticulum (HP:0002245)1.84753484
129Urethral obstruction (HP:0000796)1.84751610
130Lip pit (HP:0100267)1.84446669
131Intestinal atresia (HP:0011100)1.82034299
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81967244
133Hypothermia (HP:0002045)1.81311647
134Abnormal vertebral ossification (HP:0100569)1.80846093
135Pigmentary retinal degeneration (HP:0001146)1.80646825
136Congenital primary aphakia (HP:0007707)1.79407698
137Muscle hypertrophy of the lower extremities (HP:0008968)1.79006065
138Furrowed tongue (HP:0000221)1.78898802
139Abnormality of the ileum (HP:0001549)1.78893339
140Bifid tongue (HP:0010297)1.78705437
141Hip contracture (HP:0003273)1.78464906
142Large for gestational age (HP:0001520)1.77976383
143Myocardial infarction (HP:0001658)1.77665672
144Respiratory difficulties (HP:0002880)1.77634717
145Anencephaly (HP:0002323)1.77497640
146Abnormality of the right ventricle (HP:0001707)1.76814812
147Congenital hepatic fibrosis (HP:0002612)1.76694048
148Abnormality of the nasolacrimal system (HP:0000614)1.75472566
149Hyperinsulinemic hypoglycemia (HP:0000825)1.75294007
150Neoplasm of the tracheobronchial system (HP:0100552)1.74418390
151Cupped ribs (HP:0000887)1.73030837
152Alveolar cell carcinoma (HP:0006519)1.73022693
153Abnormality of the labia minora (HP:0012880)1.72307626
154Papillary thyroid carcinoma (HP:0002895)1.72022958
155Absent eyebrow (HP:0002223)1.71219235
156Aplasia involving bones of the upper limbs (HP:0009823)1.70580130
157Aplasia of the phalanges of the hand (HP:0009802)1.70580130
158Aplasia involving bones of the extremities (HP:0009825)1.70580130
159Abnormality of the lacrimal duct (HP:0011481)1.70564795
160Neonatal short-limb short stature (HP:0008921)1.70448751
161Epidermoid cyst (HP:0200040)1.70293114
162Symptomatic seizures (HP:0011145)1.70152076
163Hypochromic microcytic anemia (HP:0004840)1.69919360
164Vascular calcification (HP:0004934)1.69109398
165Neoplasm of the adrenal cortex (HP:0100641)1.67652838
166Preaxial foot polydactyly (HP:0001841)1.67480874
167Gait imbalance (HP:0002141)1.67474443
168Abnormal foot bone ossification (HP:0010675)1.66175824
169Hypoplastic labia majora (HP:0000059)1.64688218
170Nasolacrimal duct obstruction (HP:0000579)1.64034948
171Macroorchidism (HP:0000053)1.63559117
172Overgrowth (HP:0001548)1.63404442
173Male pseudohermaphroditism (HP:0000037)1.62978714
174Focal segmental glomerulosclerosis (HP:0000097)1.62051603
175Abnormal respiratory epithelium morphology (HP:0012253)1.61717975
176Prolonged QT interval (HP:0001657)1.61372164
177Hyperkalemia (HP:0002153)1.61270421
178Broad ribs (HP:0000885)1.60882825
179Congenital sensorineural hearing impairment (HP:0008527)1.59954578
180Aortic regurgitation (HP:0001659)1.57898113
181Pulmonic stenosis (HP:0001642)1.57570250
182Aplasia/Hypoplasia of the hallux (HP:0008362)1.57217598
183Blue irides (HP:0000635)1.57075167
184Muscle fiber splitting (HP:0003555)1.57070540
185Upper limb muscle weakness (HP:0003484)1.56907475
186Soft skin (HP:0000977)1.56816083
187Increased corneal curvature (HP:0100692)1.56107922
188Keratoconus (HP:0000563)1.56107922
189Tibial bowing (HP:0002982)1.56080531
190Bradycardia (HP:0001662)1.55183794
191Cupped ear (HP:0000378)1.54051782
192Vitreoretinal degeneration (HP:0000655)1.53785794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.24876473
2FRK3.91868536
3INSRR3.87897013
4PASK3.72714062
5ZAK2.91237985
6NUAK12.62653381
7LATS12.60454647
8WNK32.43206602
9CAMK1D2.41001747
10TGFBR12.37968837
11VRK12.37183648
12NME12.21549587
13PNCK2.17083843
14STK392.04528993
15AKT32.02046099
16OBSCN2.01421069
17TIE12.01217041
18PIK3CA1.96808432
19CAMK1G1.95804976
20TAF11.95184904
21TNIK1.88023293
22FGFR21.81878330
23ACVR1B1.80947333
24BRSK21.75270802
25TAOK31.73889826
26MAP3K141.72506351
27BUB11.70831909
28TLK11.63818518
29BMPR1B1.61473744
30TRPM71.60944002
31WEE11.55867637
32IRAK31.50976560
33CDC71.42964256
34SGK21.34832174
35MAP3K41.33438144
36BCR1.32158200
37ADRBK21.31526435
38WNK11.29991674
39CDK81.29429654
40TGFBR21.27825761
41STK161.24192013
42CASK1.21466687
43STK38L1.20250775
44MKNK11.19874898
45MUSK1.18203321
46BRD41.16862650
47STK241.16803176
48MET1.16648158
49PLK31.16400723
50NEK61.15814696
51DYRK31.15178875
52TTN1.13439971
53SIK11.13315260
54PRKAA21.12618816
55JAK11.12525815
56SRPK11.11885998
57STK31.11457380
58ERBB31.09365975
59MAP3K21.07560572
60CDK191.05584814
61LMTK21.04627224
62ADRBK11.04368743
63PRKCE1.02362791
64YES11.02097311
65DMPK1.01381708
66EPHA31.00933468
67PKN11.00384826
68PDGFRA0.99761484
69GRK10.99182419
70MST40.99121262
71MAP3K30.98139766
72EIF2AK30.97674718
73NEK20.97112389
74MAPK150.96337846
75SGK30.96044862
76FER0.94880303
77FGFR30.94590061
78DDR20.93416745
79DYRK20.93330824
80EPHA40.93136302
81IRAK10.91266382
82EIF2AK20.90187856
83SGK2230.90037247
84SGK4940.90037247
85MAP4K20.89470112
86MST1R0.89025605
87PINK10.88957010
88FGFR10.88589295
89PDGFRB0.88283615
90WNK40.86669887
91EPHA20.83605410
92OXSR10.83567338
93NEK90.82830830
94EPHB20.81066550
95GRK70.80462142
96MYLK0.77796830
97TEC0.77417972
98IRAK40.75303860
99MAPK70.74271978
100PAK30.72819689
101CCNB10.72296103
102MKNK20.71696551
103ERBB40.70974036
104EPHB10.69416817
105PLK40.69080666
106CDK120.66765691
107TRIM280.65603091
108PTK20.64605287
109AURKB0.62376728
110PRKCG0.62349325
111IGF1R0.61744308
112CHUK0.61415746
113CHEK20.61364060
114FLT30.60871735
115PRKCQ0.60430427
116MELK0.60132758
117GSK3A0.59512697
118PTK60.59360373
119MAPK130.59015157
120IRAK20.58929842
121TTK0.58470824
122BMPR20.58253292
123NLK0.57214956
124MAP3K120.57058764
125CAMK2D0.56990827
126ROCK10.56919284
127SGK10.55483854
128RIPK10.55333112
129CSNK1A1L0.54624371
130CDK30.53599126
131INSR0.53562134
132PRKAA10.52722919
133TYK20.51191687
134PDK20.50692058
135PIK3CG0.50156046
136CDK90.49188964
137MAP3K100.48644976
138PLK10.47956769
139LRRK20.46577879
140CSNK2A20.46203767
141PRKG10.46140205
142ITK0.44289261
143PBK0.44265170
144CDC42BPA0.43820430
145PRKCH0.43690886
146JAK30.43500897
147NEK10.43294024
148PRKACB0.42454631
149CSK0.41168431
150MAPKAPK50.40995372
151CSNK2A10.40876359
152ABL10.40562148
153RPS6KA50.38822233
154IKBKB0.36670730
155ATR0.36252586
156PRKACA0.35777343
157MAP2K70.33862434
158ERBB20.32900313
159DAPK30.31602018
160CSNK1E0.25949108
161ATM0.25838751

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.87361832
2Oxidative phosphorylation_Homo sapiens_hsa001904.68640028
3Parkinsons disease_Homo sapiens_hsa050123.76527319
4Huntingtons disease_Homo sapiens_hsa050162.90420754
5Protein export_Homo sapiens_hsa030602.84299073
6Alzheimers disease_Homo sapiens_hsa050102.68126095
7RNA polymerase_Homo sapiens_hsa030202.57797742
8ECM-receptor interaction_Homo sapiens_hsa045122.46019693
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41690589
10Proteasome_Homo sapiens_hsa030502.35405884
11Cardiac muscle contraction_Homo sapiens_hsa042602.22850804
12Homologous recombination_Homo sapiens_hsa034402.11429846
13Sulfur metabolism_Homo sapiens_hsa009202.05439355
14Mismatch repair_Homo sapiens_hsa034301.88259069
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79416473
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72077519
17Adherens junction_Homo sapiens_hsa045201.71105066
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64172118
19Focal adhesion_Homo sapiens_hsa045101.63881919
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.58791453
21Fanconi anemia pathway_Homo sapiens_hsa034601.56594269
22Dilated cardiomyopathy_Homo sapiens_hsa054141.48088991
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.45181077
24ABC transporters_Homo sapiens_hsa020101.42555814
25PPAR signaling pathway_Homo sapiens_hsa033201.42491910
26Fatty acid biosynthesis_Homo sapiens_hsa000611.39298008
27RNA degradation_Homo sapiens_hsa030181.36188747
28Basal transcription factors_Homo sapiens_hsa030221.33645602
29Lysine degradation_Homo sapiens_hsa003101.33425468
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33289317
31Propanoate metabolism_Homo sapiens_hsa006401.33271681
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30275764
33Nucleotide excision repair_Homo sapiens_hsa034201.29473060
34Protein digestion and absorption_Homo sapiens_hsa049741.29217479
35Vitamin digestion and absorption_Homo sapiens_hsa049771.27079914
36Fatty acid degradation_Homo sapiens_hsa000711.26975036
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23451954
38Selenocompound metabolism_Homo sapiens_hsa004501.20863634
39Fatty acid metabolism_Homo sapiens_hsa012121.18154159
40TGF-beta signaling pathway_Homo sapiens_hsa043501.16842428
41Prostate cancer_Homo sapiens_hsa052151.15905102
42Complement and coagulation cascades_Homo sapiens_hsa046101.15613823
43Spliceosome_Homo sapiens_hsa030401.14301548
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.11362832
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10869295
46Caffeine metabolism_Homo sapiens_hsa002321.10426784
47Hedgehog signaling pathway_Homo sapiens_hsa043401.09291982
48Tryptophan metabolism_Homo sapiens_hsa003801.08977186
49Phototransduction_Homo sapiens_hsa047441.05269418
50DNA replication_Homo sapiens_hsa030301.02971057
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01931904
52Proteoglycans in cancer_Homo sapiens_hsa052051.01456016
53Insulin resistance_Homo sapiens_hsa049311.01338951
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01328684
55Starch and sucrose metabolism_Homo sapiens_hsa005001.00816499
56Amoebiasis_Homo sapiens_hsa051461.00570803
57Purine metabolism_Homo sapiens_hsa002301.00461469
58Small cell lung cancer_Homo sapiens_hsa052221.00322863
59Chemical carcinogenesis_Homo sapiens_hsa052040.98112954
60Tyrosine metabolism_Homo sapiens_hsa003500.97943684
61Type II diabetes mellitus_Homo sapiens_hsa049300.97311770
62One carbon pool by folate_Homo sapiens_hsa006700.97166161
63Sphingolipid metabolism_Homo sapiens_hsa006000.96857358
64Malaria_Homo sapiens_hsa051440.94470519
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94220475
66Circadian rhythm_Homo sapiens_hsa047100.94101467
67Melanoma_Homo sapiens_hsa052180.93119123
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92931835
69RNA transport_Homo sapiens_hsa030130.92015367
70Ovarian steroidogenesis_Homo sapiens_hsa049130.91247013
71Mineral absorption_Homo sapiens_hsa049780.90674166
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90625994
73Tight junction_Homo sapiens_hsa045300.90369028
74Ether lipid metabolism_Homo sapiens_hsa005650.90231207
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88544414
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87821608
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.87748387
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87346993
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86599233
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85588841
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85114687
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.84686150
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84215808
84TNF signaling pathway_Homo sapiens_hsa046680.83431612
85Folate biosynthesis_Homo sapiens_hsa007900.83426276
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.81718970
87Pyrimidine metabolism_Homo sapiens_hsa002400.79292195
88Histidine metabolism_Homo sapiens_hsa003400.78858540
89Non-homologous end-joining_Homo sapiens_hsa034500.77138786
90Choline metabolism in cancer_Homo sapiens_hsa052310.76918508
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76556288
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76554246
93Peroxisome_Homo sapiens_hsa041460.76543950
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76182178
95Retinol metabolism_Homo sapiens_hsa008300.76038442
96Toxoplasmosis_Homo sapiens_hsa051450.75689462
97Renin-angiotensin system_Homo sapiens_hsa046140.75678507
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75146481
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74790014
100Arachidonic acid metabolism_Homo sapiens_hsa005900.74759734
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.74405596
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74173436
103MicroRNAs in cancer_Homo sapiens_hsa052060.72741016
104Basal cell carcinoma_Homo sapiens_hsa052170.71968515
105Phenylalanine metabolism_Homo sapiens_hsa003600.71061784
106Glycerolipid metabolism_Homo sapiens_hsa005610.71056588
107FoxO signaling pathway_Homo sapiens_hsa040680.69606358
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.69448775
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68552473
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68550805
111Nitrogen metabolism_Homo sapiens_hsa009100.67668979
112Metabolic pathways_Homo sapiens_hsa011000.67461023
113Hippo signaling pathway_Homo sapiens_hsa043900.65560703
114Glutathione metabolism_Homo sapiens_hsa004800.65214681
115beta-Alanine metabolism_Homo sapiens_hsa004100.64912210
116Fatty acid elongation_Homo sapiens_hsa000620.63333406
117Steroid biosynthesis_Homo sapiens_hsa001000.62066839
118Rheumatoid arthritis_Homo sapiens_hsa053230.61914832
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61755304
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61358541
121Fat digestion and absorption_Homo sapiens_hsa049750.60540192
122Hepatitis C_Homo sapiens_hsa051600.59675199
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58682866
124Inositol phosphate metabolism_Homo sapiens_hsa005620.57784223
125Pathways in cancer_Homo sapiens_hsa052000.57213258
126Axon guidance_Homo sapiens_hsa043600.56489827
127Ras signaling pathway_Homo sapiens_hsa040140.56343133
128Bile secretion_Homo sapiens_hsa049760.55605426
129Nicotine addiction_Homo sapiens_hsa050330.55250528
130African trypanosomiasis_Homo sapiens_hsa051430.53701724
131Taste transduction_Homo sapiens_hsa047420.52816354
132Renin secretion_Homo sapiens_hsa049240.52314194
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52184391
134Staphylococcus aureus infection_Homo sapiens_hsa051500.52086950
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51873428
136Rap1 signaling pathway_Homo sapiens_hsa040150.51411585
137Butanoate metabolism_Homo sapiens_hsa006500.50868330
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50018044
139cAMP signaling pathway_Homo sapiens_hsa040240.49938574
140Insulin secretion_Homo sapiens_hsa049110.48630246
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48527975
142Linoleic acid metabolism_Homo sapiens_hsa005910.48017956
143p53 signaling pathway_Homo sapiens_hsa041150.43788866
144Wnt signaling pathway_Homo sapiens_hsa043100.42997652
145Cell cycle_Homo sapiens_hsa041100.41619600
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39091135
147Pyruvate metabolism_Homo sapiens_hsa006200.39009259
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37647302
149Serotonergic synapse_Homo sapiens_hsa047260.37570872
150Collecting duct acid secretion_Homo sapiens_hsa049660.35489569
151Olfactory transduction_Homo sapiens_hsa047400.34626598
152Systemic lupus erythematosus_Homo sapiens_hsa053220.31546205
153Regulation of autophagy_Homo sapiens_hsa041400.28298819
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.28289765
155Base excision repair_Homo sapiens_hsa034100.24944102
156Asthma_Homo sapiens_hsa053100.17850885
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.16085828
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14835841

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