ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in sensory perception (GO:0050962)	4.17899171
2	detection of light stimulus involved in visual perception (GO:0050908)	4.17899171
3	indolalkylamine metabolic process (GO:0006586)	3.67164269
4	multicellular organism reproduction (GO:0032504)	3.65866874
5	DNA double-strand break processing (GO:0000729)	3.65048328
6	tryptophan catabolic process (GO:0006569)	3.61171711
7	indole-containing compound catabolic process (GO:0042436)	3.61171711
8	indolalkylamine catabolic process (GO:0046218)	3.61171711
9	kynurenine metabolic process (GO:0070189)	3.58694144
10	piRNA metabolic process (GO:0034587)	3.50918113
11	establishment of protein localization to Golgi (GO:0072600)	3.48843257
12	response to pheromone (GO:0019236)	3.46315113
13	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.32461424
14	behavioral response to nicotine (GO:0035095)	3.31830579
15	regulation of cilium movement (GO:0003352)	3.24176265
16	DNA methylation involved in gamete generation (GO:0043046)	3.22397313
17	L-fucose catabolic process (GO:0042355)	3.19160246
18	fucose catabolic process (GO:0019317)	3.19160246
19	L-fucose metabolic process (GO:0042354)	3.19160246
20	protein targeting to Golgi (GO:0000042)	3.10488063
21	protein K11-linked deubiquitination (GO:0035871)	3.08937522
22	regulation of hexokinase activity (GO:1903299)	3.08874314
23	regulation of glucokinase activity (GO:0033131)	3.08874314
24	tryptophan metabolic process (GO:0006568)	3.05906759
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05850271
26	acrosome assembly (GO:0001675)	3.04599366
27	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.02309965
28	reciprocal DNA recombination (GO:0035825)	3.01325047
29	reciprocal meiotic recombination (GO:0007131)	3.01325047
30	neural tube formation (GO:0001841)	2.97067255
31	protein polyglutamylation (GO:0018095)	2.96888957
32	regulation of meiosis I (GO:0060631)	2.96248235
33	protein localization to synapse (GO:0035418)	2.96231934
34	regulation of DNA endoreduplication (GO:0032875)	2.90908962
35	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.90499243
36	meiotic chromosome segregation (GO:0045132)	2.90273004
37	epithelial cilium movement (GO:0003351)	2.89556015
38	adaptation of signaling pathway (GO:0023058)	2.88172998
39	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.87419718
40	indole-containing compound metabolic process (GO:0042430)	2.84295416
41	serotonin metabolic process (GO:0042428)	2.81811754
42	presynaptic membrane assembly (GO:0097105)	2.79194190
43	acrosome reaction (GO:0007340)	2.77506670
44	membrane depolarization during action potential (GO:0086010)	2.76808548
45	oxidative demethylation (GO:0070989)	2.75944643
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74994155
47	protein localization to Golgi apparatus (GO:0034067)	2.72540957
48	photoreceptor cell maintenance (GO:0045494)	2.68417435
49	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.67543333
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.66871199
51	primary amino compound metabolic process (GO:1901160)	2.66745264
52	sperm motility (GO:0030317)	2.66716252
53	synapsis (GO:0007129)	2.65855751
54	male meiosis (GO:0007140)	2.65263190
55	nonmotile primary cilium assembly (GO:0035058)	2.63084069
56	cellular ketone body metabolic process (GO:0046950)	2.62618773
57	cAMP catabolic process (GO:0006198)	2.62288252
58	cellular response to sterol (GO:0036315)	2.61113865
59	cilium morphogenesis (GO:0060271)	2.60156690
60	replication fork processing (GO:0031297)	2.60037130
61	cilium organization (GO:0044782)	2.59521795
62	cyclic nucleotide catabolic process (GO:0009214)	2.58449157
63	cilium assembly (GO:0042384)	2.58298850
64	cornea development in camera-type eye (GO:0061303)	2.57099827
65	adult feeding behavior (GO:0008343)	2.56449315
66	cellular biogenic amine catabolic process (GO:0042402)	2.56144402
67	amine catabolic process (GO:0009310)	2.56144402
68	regulation of hippo signaling (GO:0035330)	2.54830820
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.54636991
70	NADH dehydrogenase complex assembly (GO:0010257)	2.54636991
71	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.54636991
72	startle response (GO:0001964)	2.52362495
73	proline transport (GO:0015824)	2.51868965
74	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.51511102
75	kidney morphogenesis (GO:0060993)	2.51440718
76	organic cation transport (GO:0015695)	2.51378704
77	postsynaptic membrane organization (GO:0001941)	2.49027488
78	magnesium ion transport (GO:0015693)	2.48587629
79	negative regulation of systemic arterial blood pressure (GO:0003085)	2.47677945
80	protein complex biogenesis (GO:0070271)	2.46887402
81	reflex (GO:0060004)	2.45639928
82	neuron cell-cell adhesion (GO:0007158)	2.45361252
83	preassembly of GPI anchor in ER membrane (GO:0016254)	2.45315988
84	hindbrain development (GO:0030902)	2.43406230
85	ketone body metabolic process (GO:1902224)	2.43098139
86	retinal cone cell development (GO:0046549)	2.41734709
87	regulation of action potential (GO:0098900)	2.41514172
88	cilium movement (GO:0003341)	2.40719692
89	intraciliary transport (GO:0042073)	2.40710248
90	regulation of microtubule-based movement (GO:0060632)	2.39766556
91	somite rostral/caudal axis specification (GO:0032525)	2.38002092
92	calcium ion import (GO:0070509)	2.37826914
93	iron ion import (GO:0097286)	2.37818384
94	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.37130482
95	respiratory chain complex IV assembly (GO:0008535)	2.36926379
96	platelet dense granule organization (GO:0060155)	2.35575718
97	positive regulation of glycolytic process (GO:0045821)	2.35316191
98	inositol phosphate catabolic process (GO:0071545)	2.34514100
99	calcium ion-dependent exocytosis (GO:0017156)	2.33869178
100	membrane repolarization during action potential (GO:0086011)	2.33557055

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.51979386
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.38417980
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.36302324
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.34520796
5	VDR_22108803_ChIP-Seq_LS180_Human	3.19504840
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.97070852
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71262062
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.57219045
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.54882527
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.43006540
11	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.36058127
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.26938450
13	P300_19829295_ChIP-Seq_ESCs_Human	2.25859825
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.25268357
15	EWS_26573619_Chip-Seq_HEK293_Human	2.25084176
16	FUS_26573619_Chip-Seq_HEK293_Human	2.18152022
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17319493
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14706661
19	AR_21572438_ChIP-Seq_LNCaP_Human	2.13962153
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.02369154
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.99161298
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.98305706
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93446059
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78602356
25	AR_25329375_ChIP-Seq_VCAP_Human	1.77153278
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.76832039
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.76692139
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.69419092
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67252428
30	STAT3_23295773_ChIP-Seq_U87_Human	1.61737866
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.61484824
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60855140
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59103422
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58482250
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58200011
36	TCF4_23295773_ChIP-Seq_U87_Human	1.53925594
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.53342119
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48941785
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.48941785
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48197650
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47691929
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46733152
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43711053
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39903288
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38496278
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38132694
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37459669
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.35209496
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34086940
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34059194
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34055408
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32747142
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32187557
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30673792
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30508644
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27956251
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26935901
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26935901
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.25567596
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21448335
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20699086
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18210092
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18188185
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18188185
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16905866
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15364629
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13247177
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12824821
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12246268
70	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.12166128
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11816735
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10665491
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10531292
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10114850
75	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.09852312
76	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08975643
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07422214
78	AHR_22903824_ChIP-Seq_MCF-7_Human	1.06448473
79	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05073121
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04813379
81	AR_20517297_ChIP-Seq_VCAP_Human	1.04528009
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04516155
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.03890387
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03423941
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03246436
86	NCOR_22424771_ChIP-Seq_293T_Human	1.02086151
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01406861
88	JUN_21703547_ChIP-Seq_K562_Human	1.00423423
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99928421
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98680368
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98351708
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95964260
93	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.94961389
94	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.94817480
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94434437
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94434437
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94015811
98	KDM2B_26808549_Chip-Seq_REH_Human	0.93693991
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93441757
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92110534

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	2.98501647
2	MP0005551_abnormal_eye_electrophysiolog	2.81211193
3	MP0008877_abnormal_DNA_methylation	2.79564788
4	MP0002736_abnormal_nociception_after	2.40207862
5	MP0001968_abnormal_touch/_nociception	2.36983971
6	MP0003718_maternal_effect	2.08798371
7	MP0006072_abnormal_retinal_apoptosis	2.06054838
8	MP0005646_abnormal_pituitary_gland	2.02659343
9	MP0002735_abnormal_chemical_nociception	1.91396428
10	MP0002837_dystrophic_cardiac_calcinosis	1.91394770
11	MP0005253_abnormal_eye_physiology	1.87434109
12	MP0002234_abnormal_pharynx_morphology	1.87223821
13	MP0008057_abnormal_DNA_replication	1.84577434
14	MP0002102_abnormal_ear_morphology	1.84141560
15	MP0003136_yellow_coat_color	1.83635553
16	MP0005410_abnormal_fertilization	1.81673857
17	MP0002938_white_spotting	1.76533642
18	MP0002876_abnormal_thyroid_physiology	1.70114465
19	MP0004043_abnormal_pH_regulation	1.68543386
20	MP0003880_abnormal_central_pattern	1.66846368
21	MP0009046_muscle_twitch	1.65540037
22	MP0003195_calcinosis	1.64302270
23	MP0006292_abnormal_olfactory_placode	1.61739188
24	MP0003787_abnormal_imprinting	1.60860876
25	MP0001984_abnormal_olfaction	1.57043544
26	MP0001501_abnormal_sleep_pattern	1.55183273
27	MP0000516_abnormal_urinary_system	1.52879841
28	MP0005367_renal/urinary_system_phenotyp	1.52879841
29	MP0001485_abnormal_pinna_reflex	1.52232563
30	MP0009745_abnormal_behavioral_response	1.51469767
31	MP0002638_abnormal_pupillary_reflex	1.50860269
32	MP0008872_abnormal_physiological_respon	1.50160301
33	MP0002557_abnormal_social/conspecific_i	1.47804750
34	MP0002572_abnormal_emotion/affect_behav	1.46222626
35	MP0000372_irregular_coat_pigmentation	1.45259161
36	MP0000631_abnormal_neuroendocrine_gland	1.40876546
37	MP0006276_abnormal_autonomic_nervous	1.40611267
38	MP0002272_abnormal_nervous_system	1.38810373
39	MP0005386_behavior/neurological_phenoty	1.37896001
40	MP0004924_abnormal_behavior	1.37896001
41	MP0002090_abnormal_vision	1.37754206
42	MP0000778_abnormal_nervous_system	1.37573165
43	MP0004145_abnormal_muscle_electrophysio	1.36211237
44	MP0008875_abnormal_xenobiotic_pharmacok	1.34523077
45	MP0003698_abnormal_male_reproductive	1.33508234
46	MP0005647_abnormal_sex_gland	1.31161733
47	MP0003121_genomic_imprinting	1.30463490
48	MP0004133_heterotaxia	1.28666399
49	MP0002064_seizures	1.27420127
50	MP0002160_abnormal_reproductive_system	1.27314206
51	MP0005645_abnormal_hypothalamus_physiol	1.25064511
52	MP0004215_abnormal_myocardial_fiber	1.23749754
53	MP0004742_abnormal_vestibular_system	1.23510634
54	MP0005174_abnormal_tail_pigmentation	1.23353375
55	MP0002063_abnormal_learning/memory/cond	1.20853790
56	MP0003011_delayed_dark_adaptation	1.19784286
57	MP0001970_abnormal_pain_threshold	1.18726528
58	MP0002733_abnormal_thermal_nociception	1.15505670
59	MP0008058_abnormal_DNA_repair	1.15059498
60	MP0001486_abnormal_startle_reflex	1.14895712
61	MP0000538_abnormal_urinary_bladder	1.14498960
62	MP0003635_abnormal_synaptic_transmissio	1.13524319
63	MP0001929_abnormal_gametogenesis	1.12276627
64	MP0000427_abnormal_hair_cycle	1.09727646
65	MP0001919_abnormal_reproductive_system	1.09332976
66	MP0002210_abnormal_sex_determination	1.08950801
67	MP0004085_abnormal_heartbeat	1.07318690
68	MP0001529_abnormal_vocalization	1.07039315
69	MP0002067_abnormal_sensory_capabilities	1.05825318
70	MP0005389_reproductive_system_phenotype	1.05762844
71	MP0005187_abnormal_penis_morphology	1.05022936
72	MP0010386_abnormal_urinary_bladder	1.03973092
73	MP0004885_abnormal_endolymph	1.01632709
74	MP0002184_abnormal_innervation	1.01230708
75	MP0005195_abnormal_posterior_eye	1.00614889
76	MP0003890_abnormal_embryonic-extraembry	0.99054305
77	MP0002653_abnormal_ependyma_morphology	0.98419473
78	MP0002734_abnormal_mechanical_nocicepti	0.97065440
79	MP0002752_abnormal_somatic_nervous	0.96279446
80	MP0000230_abnormal_systemic_arterial	0.94707204
81	MP0001502_abnormal_circadian_rhythm	0.94212074
82	MP0001986_abnormal_taste_sensitivity	0.93896741
83	MP0002909_abnormal_adrenal_gland	0.93577813
84	MP0000026_abnormal_inner_ear	0.93483709
85	MP0000653_abnormal_sex_gland	0.93457947
86	MP0004142_abnormal_muscle_tone	0.93262783
87	MP0001145_abnormal_male_reproductive	0.92729792
88	MP0005220_abnormal_exocrine_pancreas	0.91242870
89	MP0008789_abnormal_olfactory_epithelium	0.89424987
90	MP0008995_early_reproductive_senescence	0.89358945
91	MP0002229_neurodegeneration	0.89317463
92	MP0001324_abnormal_eye_pigmentation	0.88936074
93	MP0008775_abnormal_heart_ventricle	0.88785533
94	MP0005395_other_phenotype	0.86720887
95	MP0003137_abnormal_impulse_conducting	0.85373337
96	MP0001944_abnormal_pancreas_morphology	0.85064998
97	MP0003937_abnormal_limbs/digits/tail_de	0.85055012
98	MP0003283_abnormal_digestive_organ	0.82774925
99	MP0005167_abnormal_blood-brain_barrier	0.80784123
100	MP0003879_abnormal_hair_cell	0.80346080

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.86171245
2	Hypoplasia of the fovea (HP:0007750)	3.86578347
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.86578347
4	Hyperventilation (HP:0002883)	3.76717036
5	Pancreatic fibrosis (HP:0100732)	3.70335686
6	Pancreatic cysts (HP:0001737)	3.66718834
7	True hermaphroditism (HP:0010459)	3.33869528
8	Abnormality of midbrain morphology (HP:0002418)	3.33078175
9	Molar tooth sign on MRI (HP:0002419)	3.33078175
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.19046033
11	Abnormality of macular pigmentation (HP:0008002)	3.17109583
12	Abnormality of the fovea (HP:0000493)	3.10066355
13	Severe visual impairment (HP:0001141)	3.02354327
14	Protruding tongue (HP:0010808)	2.97478579
15	Abnormality of the renal cortex (HP:0011035)	2.96779617
16	Attenuation of retinal blood vessels (HP:0007843)	2.93951501
17	Nephronophthisis (HP:0000090)	2.92978764
18	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.80556406
19	Type II lissencephaly (HP:0007260)	2.79911644
20	Febrile seizures (HP:0002373)	2.78750250
21	Renal cortical cysts (HP:0000803)	2.69161047
22	Abnormality of the renal medulla (HP:0100957)	2.63037069
23	Medial flaring of the eyebrow (HP:0010747)	2.62671959
24	Chronic hepatic failure (HP:0100626)	2.59831360
25	Gaze-evoked nystagmus (HP:0000640)	2.56346210
26	Central scotoma (HP:0000603)	2.55931054
27	Broad-based gait (HP:0002136)	2.54107085
28	Male pseudohermaphroditism (HP:0000037)	2.44923328
29	Absent speech (HP:0001344)	2.36971164
30	Aplasia/Hypoplasia of the macula (HP:0008059)	2.34792671
31	Tented upper lip vermilion (HP:0010804)	2.34029890
32	Congenital sensorineural hearing impairment (HP:0008527)	2.33896146
33	Albinism (HP:0001022)	2.33076825
34	Cerebellar dysplasia (HP:0007033)	2.33070786
35	Hypothermia (HP:0002045)	2.31434278
36	Cystic liver disease (HP:0006706)	2.29204769
37	Gait imbalance (HP:0002141)	2.26800217
38	Decreased central vision (HP:0007663)	2.22956362
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.21283976
40	Decreased circulating renin level (HP:0003351)	2.21204032
41	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.20207350
42	Neoplasm of the adrenal cortex (HP:0100641)	2.18140373
43	Congenital primary aphakia (HP:0007707)	2.16201015
44	Pendular nystagmus (HP:0012043)	2.15630582
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15534067
46	Abnormality of alanine metabolism (HP:0010916)	2.14298665
47	Hyperalaninemia (HP:0003348)	2.14298665
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14298665
49	Birth length less than 3rd percentile (HP:0003561)	2.11433629
50	Short tibia (HP:0005736)	2.08461833
51	Fair hair (HP:0002286)	2.08332795
52	Inability to walk (HP:0002540)	2.08193188
53	Progressive cerebellar ataxia (HP:0002073)	2.07025267
54	Tubular atrophy (HP:0000092)	2.06216353
55	Scotoma (HP:0000575)	2.05941171
56	Furrowed tongue (HP:0000221)	2.05743989
57	Abolished electroretinogram (ERG) (HP:0000550)	2.04113853
58	Volvulus (HP:0002580)	1.99911556
59	Small hand (HP:0200055)	1.94498491
60	Optic nerve hypoplasia (HP:0000609)	1.93877893
61	Lissencephaly (HP:0001339)	1.93828302
62	Genital tract atresia (HP:0001827)	1.93498235
63	Thyroid-stimulating hormone excess (HP:0002925)	1.92855018
64	Hyperglycinuria (HP:0003108)	1.92098555
65	Intestinal atresia (HP:0011100)	1.91585105
66	Nephrogenic diabetes insipidus (HP:0009806)	1.91379986
67	Hypoplasia of the pons (HP:0012110)	1.90309002
68	Large for gestational age (HP:0001520)	1.90006862
69	Polydipsia (HP:0001959)	1.88610937
70	Abnormal drinking behavior (HP:0030082)	1.88610937
71	Widely spaced teeth (HP:0000687)	1.87492183
72	Generalized hypopigmentation of hair (HP:0011358)	1.86964396
73	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.85577428
74	Anencephaly (HP:0002323)	1.84914073
75	Hemiparesis (HP:0001269)	1.84228431
76	Abnormality of the pons (HP:0007361)	1.82538973
77	Astigmatism (HP:0000483)	1.81503475
78	Pachygyria (HP:0001302)	1.81243992
79	Azoospermia (HP:0000027)	1.80274389
80	Ketosis (HP:0001946)	1.78331636
81	Drooling (HP:0002307)	1.77700843
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77027648
83	Clumsiness (HP:0002312)	1.76675641
84	Congenital hepatic fibrosis (HP:0002612)	1.76432644
85	Poor coordination (HP:0002370)	1.76121580
86	Epileptic encephalopathy (HP:0200134)	1.75533148
87	Ketoacidosis (HP:0001993)	1.74758421
88	Colon cancer (HP:0003003)	1.74417986
89	Stomach cancer (HP:0012126)	1.74108470
90	Hepatic necrosis (HP:0002605)	1.73045261
91	Vaginal atresia (HP:0000148)	1.72613577
92	Keratoconus (HP:0000563)	1.71807142
93	Increased corneal curvature (HP:0100692)	1.71807142
94	Sclerocornea (HP:0000647)	1.71266669
95	Postaxial hand polydactyly (HP:0001162)	1.69435254
96	Bulbous nose (HP:0000414)	1.68406345
97	Dialeptic seizures (HP:0011146)	1.68318750
98	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.68197594
99	Abnormality of the axillary hair (HP:0100134)	1.67259526
100	Abnormality of secondary sexual hair (HP:0009888)	1.67259526

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.51961942
2	WNK3	3.70112267
3	AKT3	3.14657418
4	ZAK	2.92932063
5	BMPR1B	2.85983337
6	MAP4K2	2.42140041
7	CASK	2.38215311
8	ADRBK2	2.31162308
9	TNIK	2.30509891
10	ACVR1B	2.29957449
11	PINK1	2.19445618
12	NUAK1	2.14594845
13	MAPK13	2.12274027
14	GRK1	2.09569511
15	PRKD3	2.00637996
16	ERBB3	1.87468606
17	MAP3K4	1.77056942
18	PAK3	1.63224479
19	STK38L	1.55265026
20	DAPK2	1.48994574
21	MAP2K7	1.47654483
22	TAF1	1.44333183
23	TNK2	1.34653607
24	WNK4	1.27853657
25	FGFR2	1.21275453
26	BRSK2	1.18289972
27	PNCK	1.17414574
28	STK39	1.16348021
29	CAMK1G	1.15786364
30	INSRR	1.11327139
31	CSNK1A1L	1.06497377
32	MKNK2	1.02613031
33	MARK1	1.02133160
34	FER	1.01414328
35	STK3	1.00656873
36	LATS1	1.00627779
37	PLK2	0.99610276
38	CAMK1D	0.99457239
39	CCNB1	0.98005055
40	SGK2	0.96759071
41	TAOK3	0.92171632
42	TLK1	0.91611595
43	CAMKK2	0.89947115
44	TGFBR1	0.89342875
45	NTRK3	0.87610892
46	TRIM28	0.85429705
47	EIF2AK3	0.84936878
48	BRD4	0.83433348
49	PRKCE	0.83396408
50	CSNK1G3	0.80939771
51	CSNK1G1	0.78765951
52	MUSK	0.78269179
53	ADRBK1	0.77499279
54	EPHA4	0.75241331
55	CSNK1G2	0.75215859
56	BMPR2	0.74361261
57	SGK223	0.71476817
58	SGK494	0.71476817
59	PTK2B	0.68074014
60	MAPKAPK3	0.67453389
61	PLK3	0.66240314
62	VRK2	0.64755319
63	PRKCG	0.64178205
64	MAPKAPK5	0.61384172
65	PRKAA2	0.61116066
66	GRK5	0.54304083
67	WEE1	0.53705925
68	CDK8	0.51015169
69	CSNK1A1	0.49139590
70	PKN1	0.48950130
71	PHKG1	0.48723105
72	PHKG2	0.48723105
73	NTRK2	0.48554342
74	PRKCI	0.47989629
75	OXSR1	0.47963568
76	VRK1	0.47279586
77	CAMK2A	0.47083384
78	NEK2	0.45715720
79	MARK3	0.44729326
80	DYRK2	0.43784071
81	PRKCH	0.43373823
82	MKNK1	0.43265742
83	PRKAA1	0.40755640
84	PRKD2	0.40475957
85	PRKACA	0.39696195
86	CAMK1	0.39528693
87	PDK2	0.37537041
88	SIK2	0.36515578
89	BCKDK	0.35653001
90	PIK3CA	0.35395602
91	TEC	0.34899895
92	SGK3	0.31518742
93	CSNK1D	0.31316732
94	RPS6KA5	0.29921239
95	MAP2K4	0.28979419
96	ATM	0.28440214
97	CSNK1E	0.28102347
98	ATR	0.27095335
99	PRKCZ	0.26977307
100	MST4	0.25197853

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.52504751
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.48788122
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47672720
4	Caffeine metabolism_Homo sapiens_hsa00232	2.38710562
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.35774174
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20953419
7	Nicotine addiction_Homo sapiens_hsa05033	2.19354915
8	Basal transcription factors_Homo sapiens_hsa03022	2.16558318
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.09267048
10	Butanoate metabolism_Homo sapiens_hsa00650	2.09092072
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.01235125
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94251448
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.93189285
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.89912593
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84954785
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.73362223
17	Protein export_Homo sapiens_hsa03060	1.69275288
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68358706
19	Olfactory transduction_Homo sapiens_hsa04740	1.60740496
20	Propanoate metabolism_Homo sapiens_hsa00640	1.58307183
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.53152971
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.51367855
23	Morphine addiction_Homo sapiens_hsa05032	1.50997377
24	Insulin secretion_Homo sapiens_hsa04911	1.50119396
25	GABAergic synapse_Homo sapiens_hsa04727	1.45921157
26	Taste transduction_Homo sapiens_hsa04742	1.45458971
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43806149
28	Homologous recombination_Homo sapiens_hsa03440	1.41104966
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.40072573
30	Serotonergic synapse_Homo sapiens_hsa04726	1.39299853
31	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.38961447
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38131752
33	ABC transporters_Homo sapiens_hsa02010	1.37569388
34	Regulation of autophagy_Homo sapiens_hsa04140	1.34390603
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.30833182
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.30262948
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28369413
38	Circadian entrainment_Homo sapiens_hsa04713	1.27029217
39	Mineral absorption_Homo sapiens_hsa04978	1.13731228
40	Oxidative phosphorylation_Homo sapiens_hsa00190	1.11003248
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.10628353
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07461023
43	RNA polymerase_Homo sapiens_hsa03020	1.05710304
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05580194
45	Circadian rhythm_Homo sapiens_hsa04710	1.05567326
46	RNA degradation_Homo sapiens_hsa03018	1.04638840
47	Peroxisome_Homo sapiens_hsa04146	1.01038868
48	Renin secretion_Homo sapiens_hsa04924	0.98983904
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97670405
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.92135842
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89182621
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89055148
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87921879
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.86273079
55	One carbon pool by folate_Homo sapiens_hsa00670	0.86252613
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85701496
57	Parkinsons disease_Homo sapiens_hsa05012	0.79931054
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.78566017
59	Cholinergic synapse_Homo sapiens_hsa04725	0.77950141
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.77622002
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76745812
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74694174
63	Salivary secretion_Homo sapiens_hsa04970	0.73179198
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.72019328
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71714262
66	Sulfur relay system_Homo sapiens_hsa04122	0.71166870
67	Retinol metabolism_Homo sapiens_hsa00830	0.70863175
68	Huntingtons disease_Homo sapiens_hsa05016	0.69522031
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.67501209
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67486425
71	Lysine degradation_Homo sapiens_hsa00310	0.67262114
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66606097
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.64881703
74	Amphetamine addiction_Homo sapiens_hsa05031	0.64074946
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63507627
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62724916
77	Folate biosynthesis_Homo sapiens_hsa00790	0.62109872
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.61951756
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61704104
80	Alzheimers disease_Homo sapiens_hsa05010	0.60993716
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60556347
82	Long-term depression_Homo sapiens_hsa04730	0.58699199
83	Metabolic pathways_Homo sapiens_hsa01100	0.58686587
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58590747
85	Histidine metabolism_Homo sapiens_hsa00340	0.58441453
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.58017683
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57240348
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56868425
89	Fatty acid elongation_Homo sapiens_hsa00062	0.55969582
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55684884
91	Purine metabolism_Homo sapiens_hsa00230	0.54368458
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52024797
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.51074705
94	Fatty acid degradation_Homo sapiens_hsa00071	0.46175065
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45533911
96	Cocaine addiction_Homo sapiens_hsa05030	0.42890659
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.41368939
98	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40840816
99	Gastric acid secretion_Homo sapiens_hsa04971	0.40222637
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39045656

NBEAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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