ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	5.73264578
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.13499552
3	L-phenylalanine metabolic process (GO:0006558)	4.13499552
4	synaptonemal complex assembly (GO:0007130)	4.02339645
5	regulation of mitochondrial translation (GO:0070129)	3.85697556
6	GDP-mannose metabolic process (GO:0019673)	3.77042552
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.75627942
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.65977724
9	L-phenylalanine catabolic process (GO:0006559)	3.65977724
10	synaptonemal complex organization (GO:0070193)	3.62251825
11	formation of translation preinitiation complex (GO:0001731)	3.57222042
12	maturation of SSU-rRNA (GO:0030490)	3.57155961
13	pseudouridine synthesis (GO:0001522)	3.55859440
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.50553512
15	pteridine-containing compound biosynthetic process (GO:0042559)	3.47729391
16	tetrahydrofolate metabolic process (GO:0046653)	3.46040700
17	phosphate ion transmembrane transport (GO:0035435)	3.41870367
18	ribonucleoprotein complex biogenesis (GO:0022613)	3.39383618
19	proteasome assembly (GO:0043248)	3.32146140
20	chromosome organization involved in meiosis (GO:0070192)	3.31369971
21	ncRNA 3-end processing (GO:0043628)	3.26412000
22	folic acid-containing compound biosynthetic process (GO:0009396)	3.25219736
23	ribosome assembly (GO:0042255)	3.18325114
24	nucleobase-containing small molecule interconversion (GO:0015949)	3.18046481
25	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.14443464
26	ribosomal large subunit biogenesis (GO:0042273)	3.13978738
27	rRNA modification (GO:0000154)	3.09595964
28	rRNA methylation (GO:0031167)	3.08601452
29	cellular component biogenesis (GO:0044085)	3.07748049
30	GMP metabolic process (GO:0046037)	3.07220435
31	pteridine-containing compound metabolic process (GO:0042558)	3.03687207
32	respiratory electron transport chain (GO:0022904)	3.02306181
33	electron transport chain (GO:0022900)	2.96681447
34	folic acid-containing compound metabolic process (GO:0006760)	2.95083360
35	nucleotide-sugar biosynthetic process (GO:0009226)	2.91678886
36	rRNA processing (GO:0006364)	2.91229118
37	regulation of cellular amino acid metabolic process (GO:0006521)	2.90808974
38	poly(A)+ mRNA export from nucleus (GO:0016973)	2.90585199
39	translation (GO:0006412)	2.84433882
40	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.82177143
41	folic acid metabolic process (GO:0046655)	2.81352710
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.80831466
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.76574041
44	ATP synthesis coupled proton transport (GO:0015986)	2.76574041
45	rRNA metabolic process (GO:0016072)	2.75539715
46	tRNA methylation (GO:0030488)	2.75343927
47	protein complex biogenesis (GO:0070271)	2.75210188
48	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.74843018
49	ribosome biogenesis (GO:0042254)	2.74640569
50	proline biosynthetic process (GO:0006561)	2.73275900
51	glycine metabolic process (GO:0006544)	2.70661058
52	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70351396
53	cotranslational protein targeting to membrane (GO:0006613)	2.68991474
54	protein targeting to ER (GO:0045047)	2.68910327
55	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65179862
56	negative regulation of norepinephrine secretion (GO:0010700)	2.64793823
57	mitotic sister chromatid segregation (GO:0000070)	2.64436279
58	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.63033256
59	proline metabolic process (GO:0006560)	2.62958875
60	viral transcription (GO:0019083)	2.62875116
61	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.62764341
62	translational termination (GO:0006415)	2.62413094
63	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.61347966
64	phosphate ion transport (GO:0006817)	2.60808471
65	spliceosomal snRNP assembly (GO:0000387)	2.60201164
66	protein carboxylation (GO:0018214)	2.60119003
67	peptidyl-glutamic acid carboxylation (GO:0017187)	2.60119003
68	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.59931932
69	protein-cofactor linkage (GO:0018065)	2.58706527
70	protein localization to endoplasmic reticulum (GO:0070972)	2.58643474
71	translational initiation (GO:0006413)	2.58143993
72	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.58066914
73	regulation of translational fidelity (GO:0006450)	2.57226528
74	blood coagulation, intrinsic pathway (GO:0007597)	2.56794964
75	guanosine-containing compound biosynthetic process (GO:1901070)	2.56770685
76	mannosylation (GO:0097502)	2.56717408
77	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.55767028
78	fusion of sperm to egg plasma membrane (GO:0007342)	2.55463882
79	protein targeting to mitochondrion (GO:0006626)	2.55093241
80	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.53781890
81	polyketide metabolic process (GO:0030638)	2.52863917
82	doxorubicin metabolic process (GO:0044598)	2.52863917
83	daunorubicin metabolic process (GO:0044597)	2.52863917
84	aspartate family amino acid biosynthetic process (GO:0009067)	2.52693575
85	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.52649258
86	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.52649258
87	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.52649258
88	GPI anchor biosynthetic process (GO:0006506)	2.52092663
89	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.51418856
90	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.51418856
91	telomere maintenance via semi-conservative replication (GO:0032201)	2.50569921
92	GTP biosynthetic process (GO:0006183)	2.49178921
93	DNA strand elongation involved in DNA replication (GO:0006271)	2.48654273
94	DNA replication checkpoint (GO:0000076)	2.48533013
95	C-terminal protein lipidation (GO:0006501)	2.47654486
96	positive regulation of ligase activity (GO:0051351)	2.47462137
97	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.47264148
98	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.47264148
99	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.45454116
100	serine family amino acid biosynthetic process (GO:0009070)	2.44069817

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.78623307
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.01492152
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.85315917
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.79400605
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.66181206
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.21420617
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.12495956
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.11072171
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01713755
10	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.00730241
11	ZNF263_19887448_ChIP-Seq_K562_Human	2.77941734
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.75251596
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.68737179
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.59603179
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.57172477
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.49127589
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.48307798
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.43003636
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.42448491
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.29911416
21	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.26736477
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.26502223
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21178936
24	AR_21909140_ChIP-Seq_LNCAP_Human	2.20928308
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.19955357
26	XRN2_22483619_ChIP-Seq_HELA_Human	2.19417464
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.16160610
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.02566109
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.99317590
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.93293350
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87874992
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.87529223
33	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.87391851
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.85208825
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.84968191
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.78693655
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78511869
38	KDM5A_27292631_Chip-Seq_BREAST_Human	1.78103043
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.77905914
40	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.75716666
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74025683
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.72180208
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69097951
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.68077889
45	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.64831030
46	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.64546371
47	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.63346329
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61343747
49	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.57416210
50	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.57381614
51	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.53240803
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.53043273
53	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.52421747
54	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.50981058
55	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.50879256
56	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.50216781
57	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.46636949
58	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.41003742
59	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39716135
60	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.36340635
61	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.31584284
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.29618745
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27451063
64	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.27288863
65	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.23969579
66	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.23134230
67	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22997277
68	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.22132625
69	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.20747697
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.18909566
71	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.17622548
72	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.16770974
73	TFEB_21752829_ChIP-Seq_HELA_Human	1.16331252
74	VDR_22108803_ChIP-Seq_LS180_Human	1.14532037
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11690843
76	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.06470423
77	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.05824489
78	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.04215148
79	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02680968
80	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00975745
81	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00146536
82	MYC_18940864_ChIP-ChIP_HL60_Human	0.99724105
83	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.99218802
84	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.99211919
85	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.94891913
86	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94695334
87	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.92951308
88	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92217230
89	CHD1_26751641_Chip-Seq_LNCaP_Human	0.92038098
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.92011906
91	ATF3_27146783_Chip-Seq_COLON_Human	0.91826837
92	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.91360118
93	STAT1_20625510_ChIP-Seq_HELA_Human	0.90754319
94	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.88990387
95	GATA6_25053715_ChIP-Seq_YYC3_Human	0.88334273
96	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.87107200
97	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.86407133
98	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.85427222
99	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.83801390
100	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.82414538

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.34545677
2	MP0008058_abnormal_DNA_repair	3.33671720
3	MP0000372_irregular_coat_pigmentation	3.00453020
4	MP0009780_abnormal_chondrocyte_physiolo	2.88051479
5	MP0008875_abnormal_xenobiotic_pharmacok	2.79856038
6	MP0005408_hypopigmentation	2.79209066
7	MP0010094_abnormal_chromosome_stability	2.39745727
8	MP0008995_early_reproductive_senescence	2.39652701
9	MP0002938_white_spotting	2.31730167
10	MP0002160_abnormal_reproductive_system	2.26176391
11	MP0003111_abnormal_nucleus_morphology	2.17752154
12	MP0006036_abnormal_mitochondrial_physio	2.14719267
13	MP0003123_paternal_imprinting	2.12914866
14	MP0003077_abnormal_cell_cycle	2.03223652
15	MP0001661_extended_life_span	2.01945882
16	MP0008932_abnormal_embryonic_tissue	2.00943740
17	MP0003718_maternal_effect	1.96975219
18	MP0001764_abnormal_homeostasis	1.90011149
19	MP0003186_abnormal_redox_activity	1.86097575
20	MP0005360_urolithiasis	1.85563406
21	MP0003786_premature_aging	1.80835281
22	MP0005332_abnormal_amino_acid	1.74863558
23	MP0003693_abnormal_embryo_hatching	1.73330063
24	MP0005410_abnormal_fertilization	1.70596332
25	MP0002139_abnormal_hepatobiliary_system	1.68200315
26	MP0005646_abnormal_pituitary_gland	1.68047752
27	MP0010234_abnormal_vibrissa_follicle	1.65041305
28	MP0004957_abnormal_blastocyst_morpholog	1.62266837
29	MP0008057_abnormal_DNA_replication	1.61978219
30	MP0000678_abnormal_parathyroid_gland	1.60556825
31	MP0001881_abnormal_mammary_gland	1.55207502
32	MP0005389_reproductive_system_phenotype	1.51818697
33	MP0005365_abnormal_bile_salt	1.51106753
34	MP0009697_abnormal_copulation	1.50980257
35	MP0006035_abnormal_mitochondrial_morpho	1.50395053
36	MP0000013_abnormal_adipose_tissue	1.44489538
37	MP0005058_abnormal_lysosome_morphology	1.39504574
38	MP0005451_abnormal_body_composition	1.37591262
39	MP0004272_abnormal_basement_membrane	1.35376650
40	MP0001666_abnormal_nutrient_absorption	1.33919380
41	MP0005085_abnormal_gallbladder_physiolo	1.33228184
42	MP0002132_abnormal_respiratory_system	1.31036398
43	MP0005187_abnormal_penis_morphology	1.30324433
44	MP0000358_abnormal_cell_content/	1.30266131
45	MP0001929_abnormal_gametogenesis	1.25417329
46	MP0002876_abnormal_thyroid_physiology	1.23968146
47	MP0004019_abnormal_vitamin_homeostasis	1.23501714
48	MP0002090_abnormal_vision	1.20598817
49	MP0005464_abnormal_platelet_physiology	1.18784065
50	MP0008007_abnormal_cellular_replicative	1.17878880
51	MP0002210_abnormal_sex_determination	1.17736483
52	MP0000681_abnormal_thyroid_gland	1.14975445
53	MP0003698_abnormal_male_reproductive	1.12152946
54	MP0008775_abnormal_heart_ventricle	1.08327731
55	MP0000653_abnormal_sex_gland	1.07216351
56	MP0004147_increased_porphyrin_level	1.06989594
57	MP0002877_abnormal_melanocyte_morpholog	1.06037427
58	MP0001502_abnormal_circadian_rhythm	1.04305300
59	MP0001919_abnormal_reproductive_system	1.02146634
60	MP0003699_abnormal_female_reproductive	1.00899837
61	MP0001697_abnormal_embryo_size	1.00241984
62	MP0001905_abnormal_dopamine_level	0.97932555
63	MP0000003_abnormal_adipose_tissue	0.97137454
64	MP0001944_abnormal_pancreas_morphology	0.95997622
65	MP0001145_abnormal_male_reproductive	0.95073958
66	MP0005084_abnormal_gallbladder_morpholo	0.93829703
67	MP0003315_abnormal_perineum_morphology	0.93540403
68	MP0010329_abnormal_lipoprotein_level	0.91414563
69	MP0002102_abnormal_ear_morphology	0.91312471
70	MP0000350_abnormal_cell_proliferation	0.91271865
71	MP0001119_abnormal_female_reproductive	0.88863097
72	MP0005501_abnormal_skin_physiology	0.88345620
73	MP0008260_abnormal_autophagy	0.87337806
74	MP0000609_abnormal_liver_physiology	0.86584411
75	MP0001270_distended_abdomen	0.86291244
76	MP0005330_cardiomyopathy	0.86121271
77	MP0000627_abnormal_mammary_gland	0.86095978
78	MP0002161_abnormal_fertility/fecundity	0.86089982
79	MP0000598_abnormal_liver_morphology	0.84151389
80	MP0002638_abnormal_pupillary_reflex	0.84120223
81	MP0002837_dystrophic_cardiac_calcinosis	0.81440485
82	MP0003943_abnormal_hepatobiliary_system	0.79822190
83	MP0004808_abnormal_hematopoietic_stem	0.79811043
84	MP0009046_muscle_twitch	0.79786576
85	MP0010386_abnormal_urinary_bladder	0.79394802
86	MP0003868_abnormal_feces_composition	0.79289347
87	MP0004782_abnormal_surfactant_physiolog	0.78285158
88	MP0001756_abnormal_urination	0.77116393
89	MP0003936_abnormal_reproductive_system	0.76923341
90	MP0000639_abnormal_adrenal_gland	0.74916616
91	MP0003195_calcinosis	0.74422645
92	MP0005636_abnormal_mineral_homeostasis	0.71941553
93	MP0005551_abnormal_eye_electrophysiolog	0.71297285
94	MP0003136_yellow_coat_color	0.71125734
95	MP0000647_abnormal_sebaceous_gland	0.70858251
96	MP0004858_abnormal_nervous_system	0.68771768
97	MP0005380_embryogenesis_phenotype	0.68486842
98	MP0001672_abnormal_embryogenesis/_devel	0.68486842
99	MP0002080_prenatal_lethality	0.67016048
100	MP0003953_abnormal_hormone_level	0.65604236

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	4.44286677
2	Acute necrotizing encephalopathy (HP:0006965)	4.17699149
3	Renal Fanconi syndrome (HP:0001994)	3.98523529
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.94521990
5	Increased hepatocellular lipid droplets (HP:0006565)	3.91972150
6	Acute encephalopathy (HP:0006846)	3.91808072
7	Fibular aplasia (HP:0002990)	3.85762907
8	Lipid accumulation in hepatocytes (HP:0006561)	3.81673667
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.75942144
10	Progressive macrocephaly (HP:0004481)	3.52834697
11	Increased CSF lactate (HP:0002490)	3.42160342
12	Type I transferrin isoform profile (HP:0003642)	3.37320993
13	Abnormality of glycolysis (HP:0004366)	3.32821645
14	Increased serum pyruvate (HP:0003542)	3.28183712
15	Mitochondrial inheritance (HP:0001427)	3.27441396
16	Hypoplastic pelvis (HP:0008839)	2.96518915
17	Hyperthyroidism (HP:0000836)	2.95345110
18	Deep venous thrombosis (HP:0002625)	2.89941367
19	Septate vagina (HP:0001153)	2.85277753
20	Reduced antithrombin III activity (HP:0001976)	2.73840005
21	Increased intramyocellular lipid droplets (HP:0012240)	2.68877149
22	Cerebral edema (HP:0002181)	2.62719042
23	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.59941160
24	Abnormal protein N-linked glycosylation (HP:0012347)	2.59941160
25	Abnormal protein glycosylation (HP:0012346)	2.59941160
26	Abnormal glycosylation (HP:0012345)	2.59941160
27	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.59299713
28	Vaginal fistula (HP:0004320)	2.58036695
29	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.55276865
30	Abnormality of the intrinsic pathway (HP:0010989)	2.55038413
31	Hypobetalipoproteinemia (HP:0003563)	2.54657573
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.54402599
33	Abnormality of cochlea (HP:0000375)	2.50723150
34	Birth length less than 3rd percentile (HP:0003561)	2.48854250
35	Increased muscle lipid content (HP:0009058)	2.46389382
36	Chromsome breakage (HP:0040012)	2.42656526
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.38373214
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.38373214
39	Tongue fasciculations (HP:0001308)	2.36588492
40	Vascular calcification (HP:0004934)	2.34792191
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.33997127
42	Neuroendocrine neoplasm (HP:0100634)	2.32618309
43	Exertional dyspnea (HP:0002875)	2.29987822
44	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.29418770
45	Upper limb muscle weakness (HP:0003484)	2.25791893
46	Increased serum lactate (HP:0002151)	2.15152440
47	Abnormality of renal resorption (HP:0011038)	2.13454787
48	Hepatic necrosis (HP:0002605)	2.12784150
49	Exercise intolerance (HP:0003546)	2.11980944
50	Oligodactyly (hands) (HP:0001180)	2.11529311
51	Cutaneous melanoma (HP:0012056)	2.10726725
52	Microglossia (HP:0000171)	2.10252071
53	Rectovaginal fistula (HP:0000143)	2.08850687
54	Rectal fistula (HP:0100590)	2.08850687
55	Lactic acidosis (HP:0003128)	2.08632550
56	Abnormal pupillary function (HP:0007686)	2.08256534
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07489338
58	Abnormality of alanine metabolism (HP:0010916)	2.07489338
59	Hyperalaninemia (HP:0003348)	2.07489338
60	Abnormality of the Achilles tendon (HP:0005109)	2.06275318
61	Hepatocellular necrosis (HP:0001404)	2.03376773
62	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.03017965
63	Menorrhagia (HP:0000132)	2.02726397
64	Athetosis (HP:0002305)	2.02456785
65	Generalized aminoaciduria (HP:0002909)	2.02323643
66	Renal tubular dysfunction (HP:0000124)	1.97728823
67	Respiratory difficulties (HP:0002880)	1.95530158
68	Cardiovascular calcification (HP:0011915)	1.95386505
69	Lethargy (HP:0001254)	1.92123150
70	Pheochromocytoma (HP:0002666)	1.91935611
71	Respiratory failure (HP:0002878)	1.90512394
72	Hypoplasia of the pons (HP:0012110)	1.86145095
73	Hypokinesia (HP:0002375)	1.85764948
74	Abnormality of the common coagulation pathway (HP:0010990)	1.85031732
75	Horseshoe kidney (HP:0000085)	1.85014301
76	Abnormality of urine glucose concentration (HP:0011016)	1.82645089
77	Glycosuria (HP:0003076)	1.82645089
78	Hypothermia (HP:0002045)	1.80931702
79	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.79888669
80	Abnormality of the pons (HP:0007361)	1.78674744
81	Sparse eyelashes (HP:0000653)	1.78046184
82	Leukodystrophy (HP:0002415)	1.77473172
83	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77057292
84	Optic disc pallor (HP:0000543)	1.75489598
85	Abnormality of the preputium (HP:0100587)	1.74973978
86	Hypergonadotropic hypogonadism (HP:0000815)	1.74781950
87	3-Methylglutaconic aciduria (HP:0003535)	1.74370340
88	Epiphyseal stippling (HP:0010655)	1.73599298
89	Abnormality of methionine metabolism (HP:0010901)	1.73351278
90	Cerebral hypomyelination (HP:0006808)	1.72828819
91	Meckel diverticulum (HP:0002245)	1.72122802
92	Morphological abnormality of the inner ear (HP:0011390)	1.71199999
93	Muscle fibrillation (HP:0010546)	1.69406428
94	Abnormality of the ileum (HP:0001549)	1.69340074
95	Squamous cell carcinoma (HP:0002860)	1.68360384
96	Secondary amenorrhea (HP:0000869)	1.68119032
97	Abnormality of subcutaneous fat tissue (HP:0001001)	1.67977146
98	Small epiphyses (HP:0010585)	1.66905894
99	Joint hemorrhage (HP:0005261)	1.66670256
100	Conjunctival hamartoma (HP:0100780)	1.64747493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.62086729
2	NME2	3.49136653
3	MST4	3.37078759
4	TRIM28	3.25153448
5	IRAK3	3.19213152
6	MST1R	2.96770705
7	BUB1	2.52282789
8	MAPKAPK3	2.43733305
9	EPHA2	2.43039636
10	EIF2AK3	2.22715259
11	SIK3	1.93579849
12	ILK	1.79135791
13	CCNB1	1.78015188
14	WEE1	1.72621203
15	ARAF	1.72442574
16	STK16	1.71944134
17	ZAK	1.68553895
18	BMPR1B	1.68167359
19	NEK2	1.66997151
20	EEF2K	1.65380502
21	SRPK1	1.61711859
22	PBK	1.55809145
23	PINK1	1.55318430
24	BRSK2	1.52444665
25	FRK	1.51823179
26	BRSK1	1.42476372
27	FGFR4	1.34676268
28	NEK1	1.32418277
29	TTK	1.31067789
30	MET	1.26371117
31	CDK8	1.24438856
32	SCYL2	1.24421040
33	STK3	1.22017420
34	RPS6KB2	1.18876529
35	PRKCI	1.18308079
36	LATS1	1.14960796
37	FGFR3	1.13040913
38	PDK2	1.12070530
39	MYLK	1.10504917
40	TLK1	1.04217213
41	MARK3	1.00575838
42	PLK3	0.99977928
43	BMPR2	0.98768775
44	CDK7	0.96972707
45	TESK1	0.93566720
46	PLK1	0.91371105
47	AURKB	0.90878558
48	MAP3K12	0.89834143
49	ERBB3	0.88390875
50	NME1	0.87817417
51	WNK4	0.87482284
52	CDC7	0.87262189
53	BCR	0.85684629
54	TRPM7	0.85334601
55	PIM2	0.81991248
56	LIMK1	0.78808049
57	LATS2	0.77427948
58	ABL2	0.76772820
59	ICK	0.74189824
60	DAPK3	0.73673897
61	BRAF	0.73333784
62	AKT2	0.71961629
63	BMX	0.71276149
64	VRK2	0.69756830
65	CSNK2A2	0.65265719
66	MAP3K3	0.65128885
67	PLK4	0.63928489
68	CSNK2A1	0.62981067
69	PAK1	0.61891165
70	CHEK1	0.61756835
71	CHEK2	0.60786465
72	PTK2	0.60343478
73	ATR	0.59895731
74	CSNK1E	0.55979688
75	FER	0.55485489
76	EPHA3	0.55124954
77	EIF2AK2	0.50987352
78	MAPKAPK5	0.50854348
79	RPS6KA5	0.49867751
80	MAPKAPK2	0.46936111
81	RPS6KB1	0.45781855
82	ERBB4	0.45665301
83	FGFR2	0.45044193
84	TSSK6	0.44664716
85	INSRR	0.44629081
86	ATM	0.43625680
87	PHKG1	0.42800882
88	PHKG2	0.42800882
89	STK24	0.40406464
90	RIPK1	0.40332455
91	ERN1	0.39305693
92	DAPK1	0.39266429
93	LRRK2	0.38109290
94	AURKA	0.37711417
95	PAK4	0.34299700
96	GRK1	0.33298622
97	STK4	0.32521207
98	FGFR1	0.32495860
99	MAP3K2	0.31256855
100	CDK12	0.30763189

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.31279138
2	Ribosome_Homo sapiens_hsa03010	3.15607392
3	One carbon pool by folate_Homo sapiens_hsa00670	3.09055809
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.92759147
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44899605
6	DNA replication_Homo sapiens_hsa03030	2.43820605
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.40571795
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.26611055
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20759256
10	Folate biosynthesis_Homo sapiens_hsa00790	2.08330212
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.06061573
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.04578457
13	Mismatch repair_Homo sapiens_hsa03430	2.02194730
14	RNA polymerase_Homo sapiens_hsa03020	1.97314292
15	Parkinsons disease_Homo sapiens_hsa05012	1.95874885
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.88890771
17	Homologous recombination_Homo sapiens_hsa03440	1.85647163
18	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.78728042
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.68718307
20	Protein export_Homo sapiens_hsa03060	1.67847742
21	RNA transport_Homo sapiens_hsa03013	1.58198583
22	Sulfur metabolism_Homo sapiens_hsa00920	1.58026879
23	Sulfur relay system_Homo sapiens_hsa04122	1.56887962
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.52818755
25	Spliceosome_Homo sapiens_hsa03040	1.47288457
26	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.46599063
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.38484825
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.38305663
29	Huntingtons disease_Homo sapiens_hsa05016	1.36977178
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.32713764
31	Complement and coagulation cascades_Homo sapiens_hsa04610	1.30463722
32	Glutathione metabolism_Homo sapiens_hsa00480	1.30410269
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.29742343
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29422359
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.26728942
36	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.25867172
37	Alzheimers disease_Homo sapiens_hsa05010	1.25410716
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.25050473
39	Basal transcription factors_Homo sapiens_hsa03022	1.21921371
40	Base excision repair_Homo sapiens_hsa03410	1.19549972
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.19228001
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.18856027
43	Tyrosine metabolism_Homo sapiens_hsa00350	1.18122925
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13611926
45	Arginine biosynthesis_Homo sapiens_hsa00220	1.12805124
46	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11515008
47	Pyruvate metabolism_Homo sapiens_hsa00620	1.08675293
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07641750
49	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.01590395
50	Steroid biosynthesis_Homo sapiens_hsa00100	1.01149189
51	Purine metabolism_Homo sapiens_hsa00230	1.00718048
52	Galactose metabolism_Homo sapiens_hsa00052	1.00112912
53	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.98935111
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98316442
55	Cell cycle_Homo sapiens_hsa04110	0.97878463
56	Metabolic pathways_Homo sapiens_hsa01100	0.97453806
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.97290483
58	RNA degradation_Homo sapiens_hsa03018	0.90957570
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90849493
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.90818476
61	Peroxisome_Homo sapiens_hsa04146	0.87318596
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87137581
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86568408
64	Fatty acid elongation_Homo sapiens_hsa00062	0.85968116
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84850520
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84488786
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83571102
68	Carbon metabolism_Homo sapiens_hsa01200	0.79000405
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.77423710
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75292662
71	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.75133725
72	Propanoate metabolism_Homo sapiens_hsa00640	0.73530137
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.69720093
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69162845
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.68234185
76	Pentose phosphate pathway_Homo sapiens_hsa00030	0.67239548
77	Other glycan degradation_Homo sapiens_hsa00511	0.61000850
78	Retinol metabolism_Homo sapiens_hsa00830	0.60855613
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60190345
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59605723
81	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.53536012
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51172210
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.50783186
84	p53 signaling pathway_Homo sapiens_hsa04115	0.47945969
85	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47063225
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.46616398
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45788452
88	Butanoate metabolism_Homo sapiens_hsa00650	0.44756012
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42307896
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42267399
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.41011703
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.40364326
93	Oocyte meiosis_Homo sapiens_hsa04114	0.39087780
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.38986239
95	Fatty acid degradation_Homo sapiens_hsa00071	0.38795113
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.36821494
97	ABC transporters_Homo sapiens_hsa02010	0.36625418
98	Phototransduction_Homo sapiens_hsa04744	0.35889885
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31208081
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30609843

NBEAP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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