NBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host (GO:0044406)4.78600865
2protein heterotrimerization (GO:0070208)4.45060404
3angiotensin maturation (GO:0002003)4.27961818
4collagen fibril organization (GO:0030199)4.17308921
5barbed-end actin filament capping (GO:0051016)3.88006136
6negative regulation of complement activation (GO:0045916)3.65019505
7plasma membrane repair (GO:0001778)3.60579431
8stress fiber assembly (GO:0043149)3.56102848
9extracellular fibril organization (GO:0043206)3.54357329
10hemidesmosome assembly (GO:0031581)3.54218935
11positive regulation of pseudopodium assembly (GO:0031274)3.54107089
12regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.50336234
13chondrocyte proliferation (GO:0035988)3.27471793
14cell migration involved in heart development (GO:0060973)3.26249582
15regulation of extracellular matrix disassembly (GO:0010715)3.25311334
16extracellular matrix assembly (GO:0085029)3.24721788
17axon extension involved in axon guidance (GO:0048846)3.22115648
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.22115648
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.19282236
20regulation of pseudopodium assembly (GO:0031272)3.13614647
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.13536390
22collagen metabolic process (GO:0032963)3.09107133
23collagen catabolic process (GO:0030574)3.04456978
24fibril organization (GO:0097435)3.02608380
25multicellular organismal macromolecule metabolic process (GO:0044259)3.01827804
26protein targeting to plasma membrane (GO:0072661)2.98907021
27protein localization to endosome (GO:0036010)2.98386597
28endodermal cell differentiation (GO:0035987)2.93844787
29cell adhesion mediated by integrin (GO:0033627)2.93052649
30Golgi transport vesicle coating (GO:0048200)2.92105522
31COPI coating of Golgi vesicle (GO:0048205)2.92105522
32negative regulation of catenin import into nucleus (GO:0035414)2.89663491
33skin morphogenesis (GO:0043589)2.88890457
34multicellular organismal catabolic process (GO:0044243)2.88768413
35regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87849874
36type B pancreatic cell proliferation (GO:0044342)2.87234110
37basement membrane organization (GO:0071711)2.86310975
38extracellular matrix disassembly (GO:0022617)2.84209917
39renal filtration (GO:0097205)2.84111858
40multicellular organismal metabolic process (GO:0044236)2.83522768
41keratan sulfate catabolic process (GO:0042340)2.81902179
42NADH metabolic process (GO:0006734)2.81861525
43metanephric mesenchyme development (GO:0072075)2.81060499
44cytoskeletal anchoring at plasma membrane (GO:0007016)2.78312023
45endothelial cell chemotaxis (GO:0035767)2.76611359
46positive regulation of receptor recycling (GO:0001921)2.75985355
47epithelial cell-cell adhesion (GO:0090136)2.75198283
48negative regulation of protein activation cascade (GO:2000258)2.74676816
49glomerular basement membrane development (GO:0032836)2.73669017
50regulation of guanylate cyclase activity (GO:0031282)2.71045529
51renal system process involved in regulation of blood volume (GO:0001977)2.70875608
52glomerular filtration (GO:0003094)2.67205460
53negative regulation of fatty acid transport (GO:2000192)2.65613024
54bone trabecula formation (GO:0060346)2.65470829
55regulation of vitamin metabolic process (GO:0030656)2.64171649
56kidney mesenchyme development (GO:0072074)2.63274240
57organ induction (GO:0001759)2.63160124
58cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61197728
59endocytic recycling (GO:0032456)2.59740620
60cyclooxygenase pathway (GO:0019371)2.57694081
61peptide catabolic process (GO:0043171)2.57531909
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.53857675
63negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53373307
64positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49564460
65apoptotic cell clearance (GO:0043277)2.47527384
66adhesion of symbiont to host cell (GO:0044650)2.47219751
67virion attachment to host cell (GO:0019062)2.47219751
68vascular endothelial growth factor signaling pathway (GO:0038084)2.46139592
69cellular response to nutrient (GO:0031670)2.45810838
70mesenchymal-epithelial cell signaling (GO:0060638)2.45315851
71negative regulation of humoral immune response (GO:0002921)2.43365127
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.43338125
73cell-substrate junction assembly (GO:0007044)2.42661465
74blood vessel maturation (GO:0001955)2.41754729
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.39216365
76cGMP-mediated signaling (GO:0019934)2.38511992
77dermatan sulfate biosynthetic process (GO:0030208)2.38058502
78glycosphingolipid catabolic process (GO:0046479)2.37603367
79synaptic vesicle docking involved in exocytosis (GO:0016081)2.37266492
80branching involved in salivary gland morphogenesis (GO:0060445)2.37052637
81planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36518469
82sexual reproduction (GO:0019953)2.36406912
83extracellular matrix organization (GO:0030198)2.35607901
84positive regulation of p38MAPK cascade (GO:1900745)2.35010376
85semaphorin-plexin signaling pathway (GO:0071526)2.34891817
86extracellular structure organization (GO:0043062)2.34341438
87regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.33780329
88endocrine process (GO:0050886)2.33780329
89regulation of systemic arterial blood pressure by hormone (GO:0001990)2.33780329
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32944709
91outer ear morphogenesis (GO:0042473)2.32374149
92mannose metabolic process (GO:0006013)2.30423596
93negative regulation of heart growth (GO:0061117)2.29149004
94negative regulation of cardiac muscle tissue growth (GO:0055022)2.29149004
95adherens junction assembly (GO:0034333)2.28996655
96intestinal absorption (GO:0050892)2.28753926
97sodium ion export (GO:0071436)2.28684631
98positive regulation of endothelial cell apoptotic process (GO:2000353)2.28477092
99protein retention in ER lumen (GO:0006621)2.28359600
100positive regulation of axon extension (GO:0045773)2.27722936
101wound healing, spreading of epidermal cells (GO:0035313)2.27467460
102actin filament capping (GO:0051693)2.27306282
103regulation of p38MAPK cascade (GO:1900744)2.27056702
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26997099
105peptide cross-linking (GO:0018149)2.26754918
106negative regulation of chondrocyte differentiation (GO:0032331)2.26369878
107lymphangiogenesis (GO:0001946)2.25616325
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.25229475
109positive regulation of cartilage development (GO:0061036)2.25179953
110embryo implantation (GO:0007566)2.24892797
111regulation of cellular extravasation (GO:0002691)2.24250110
112glycolipid catabolic process (GO:0019377)2.23093559
113cardiac muscle cell proliferation (GO:0060038)2.22902420
114growth hormone secretion (GO:0030252)2.22122665
115regulation of membrane protein ectodomain proteolysis (GO:0051043)2.21912066
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21792865
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.21764952
118cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.21723526
119negative regulation of smooth muscle cell migration (GO:0014912)2.21127938
120regulation of cholesterol homeostasis (GO:2000188)2.20798329
121regulation of systemic arterial blood pressure (GO:0003073)2.20587743
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.20252826
123negative regulation of adherens junction organization (GO:1903392)2.20017451
124negative regulation of focal adhesion assembly (GO:0051895)2.20017451
125negative regulation of cell junction assembly (GO:1901889)2.20017451
126membrane budding (GO:0006900)2.19732871
127lipoprotein transport (GO:0042953)2.19687570
128regulation of axon extension involved in axon guidance (GO:0048841)2.19612074
129cell migration in hindbrain (GO:0021535)2.17907636
130regulation of apoptotic process involved in morphogenesis (GO:1902337)2.17297904
131fat-soluble vitamin biosynthetic process (GO:0042362)2.17269557
132complement activation, classical pathway (GO:0006958)2.16593340
133positive regulation of blood vessel endothelial cell migration (GO:0043536)2.16361396
134lung lobe morphogenesis (GO:0060463)2.15071223
135chondroitin sulfate catabolic process (GO:0030207)2.14541610
136sodium ion homeostasis (GO:0055078)2.14323621
137desmosome organization (GO:0002934)2.13174202
138retina vasculature morphogenesis in camera-type eye (GO:0061299)2.12105892
139dermatan sulfate metabolic process (GO:0030205)2.11982895
140regulation of early endosome to late endosome transport (GO:2000641)2.11050609
141peptidyl-proline hydroxylation (GO:0019511)2.10990685
142layer formation in cerebral cortex (GO:0021819)2.10988086
143positive regulation of fibroblast migration (GO:0010763)2.10702499
144surfactant homeostasis (GO:0043129)2.10334686
145regulation of tight junction assembly (GO:2000810)2.09835821
146response to water (GO:0009415)2.08211521
147actin filament depolymerization (GO:0030042)2.07256519
148regulation of cartilage development (GO:0061035)2.06204409
149regulation of integrin-mediated signaling pathway (GO:2001044)2.05901232
150glial cell migration (GO:0008347)2.05258022
151endocardial cushion development (GO:0003197)2.04711137
152axon extension (GO:0048675)2.04640357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.15228496
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.54237660
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.19143051
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35877665
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35877665
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35266931
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.32063574
8CLOCK_20551151_ChIP-Seq_293T_Human2.17606424
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.16953796
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16503887
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.14544957
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13186008
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12281313
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09291387
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08641898
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06581814
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.99217705
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94626233
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92102484
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90990213
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.78776140
22* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77227506
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75609550
24* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74293553
25CJUN_26792858_Chip-Seq_BT549_Human1.69080990
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68585100
27* EZH2_27304074_Chip-Seq_ESCs_Mouse1.67503841
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65701148
29EZH2_22144423_ChIP-Seq_EOC_Human1.64294559
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.64264009
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.62015887
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60741590
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57437876
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56705017
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.56590258
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55914042
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55605554
38ZNF263_19887448_ChIP-Seq_K562_Human1.53753673
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53096142
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51144942
41* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50114858
42* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46151394
43* TP53_20018659_ChIP-ChIP_R1E_Mouse1.45823725
44* KDM2B_26808549_Chip-Seq_K562_Human1.45759182
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43459350
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.42502765
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.42128374
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41986842
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41835133
50DROSHA_22980978_ChIP-Seq_HELA_Human1.41748370
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41384474
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36466587
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36314049
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33691226
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33675580
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33307798
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33215436
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33146400
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31580097
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.31429975
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29249877
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.28560859
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27777386
64SOX2_20726797_ChIP-Seq_SW620_Human1.26776089
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.26201887
66KDM2B_26808549_Chip-Seq_DND41_Human1.25023435
67* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23019792
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22689171
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22505005
70LXR_22292898_ChIP-Seq_THP-1_Human1.22328780
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20324798
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20162895
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19883696
74AHR_22903824_ChIP-Seq_MCF-7_Human1.18457030
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17496867
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17496867
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17344866
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17275987
79* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16777364
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16728389
81TP53_22127205_ChIP-Seq_IMR90_Human1.16526677
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.16290003
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16016727
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.15881382
85* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15298993
86SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14466608
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13565543
88TP53_18474530_ChIP-ChIP_U2OS_Human1.13528062
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.13292085
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13149699
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12838697
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.11674620
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11504284
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11351772
95SMC4_20622854_ChIP-Seq_HELA_Human1.11292004
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11155905
97CREB1_26743006_Chip-Seq_LNCaP_Human1.10945679
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.10215613
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08937614
100VDR_21846776_ChIP-Seq_THP-1_Human1.08599844
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08531029
102TCF7_22412390_ChIP-Seq_EML_Mouse1.06715020
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06258703
104TP63_22573176_ChIP-Seq_HFKS_Human1.06213613
105* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06148851
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04493114
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03974550
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03902655
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03693418
110* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03324700
111* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03208409
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.02940531
113* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02647279
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02456742
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02296895
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00890021
117* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00137394
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99994931
119ATF3_27146783_Chip-Seq_COLON_Human0.99085291
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99047691
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99047691
122* TBX20_22080862_ChIP-Seq_HEART_Mouse0.98555232
123* TBX20_22328084_ChIP-Seq_HEART_Mouse0.98555232
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.97678088
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96909835
126P68_20966046_ChIP-Seq_HELA_Human0.95846310
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.95387805
128KLF5_25053715_ChIP-Seq_YYC3_Human0.94503783
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93563558
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.93103480
131AR_21572438_ChIP-Seq_LNCaP_Human0.92120543
132* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91622076
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90857279
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90548343
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89098174
136* CTCF_27219007_Chip-Seq_Bcells_Human0.88263882
137TP53_23651856_ChIP-Seq_MEFs_Mouse0.86555637
138* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86377170
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86165722
140ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85708410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.44334872
2MP0005275_abnormal_skin_tensile4.76104825
3MP0005503_abnormal_tendon_morphology4.22016736
4MP0001958_emphysema4.08580539
5MP0003279_aneurysm3.27501126
6MP0003705_abnormal_hypodermis_morpholog3.22519342
7MP0006054_spinal_hemorrhage2.77957922
8MP0005360_urolithiasis2.59469368
9MP0004272_abnormal_basement_membrane2.51394746
10MP0004858_abnormal_nervous_system2.48206748
11MP0009840_abnormal_foam_cell2.44254111
12MP0005058_abnormal_lysosome_morphology2.30060052
13MP0005409_darkened_coat_color2.28928262
14MP0005623_abnormal_meninges_morphology2.14764268
15MP0009379_abnormal_foot_pigmentation2.01084789
16MP0003566_abnormal_cell_adhesion1.95978600
17MP0000013_abnormal_adipose_tissue1.92584622
18MP0000751_myopathy1.91974364
19MP0010368_abnormal_lymphatic_system1.91276031
20MP0005508_abnormal_skeleton_morphology1.78348463
21MP0009384_cardiac_valve_regurgitation1.75976460
22MP0009780_abnormal_chondrocyte_physiolo1.70732370
23MP0000534_abnormal_ureter_morphology1.65951031
24MP0002295_abnormal_pulmonary_circulatio1.64357766
25MP0001542_abnormal_bone_strength1.58023945
26MP0002060_abnormal_skin_morphology1.55236797
27MP0003183_abnormal_peptide_metabolism1.55053631
28MP0002837_dystrophic_cardiac_calcinosis1.54959928
29MP0004859_abnormal_synaptic_plasticity1.54841554
30MP0002796_impaired_skin_barrier1.54510403
31MP0001299_abnormal_eye_distance/1.52468591
32MP0002254_reproductive_system_inflammat1.47053782
33MP0002108_abnormal_muscle_morphology1.43198927
34MP0010030_abnormal_orbit_morphology1.41622724
35MP0002735_abnormal_chemical_nociception1.41394291
36MP0001879_abnormal_lymphatic_vessel1.41132443
37MP0009250_abnormal_appendicular_skeleto1.40184139
38MP0005257_abnormal_intraocular_pressure1.38969609
39MP0003045_fibrosis1.35939655
40MP0003453_abnormal_keratinocyte_physiol1.35776927
41MP0000678_abnormal_parathyroid_gland1.33456250
42MP0002896_abnormal_bone_mineralization1.32140749
43MP0003385_abnormal_body_wall1.31906991
44MP0004270_analgesia1.29536092
45MP0003091_abnormal_cell_migration1.29341428
46MP0000767_abnormal_smooth_muscle1.28768891
47MP0005023_abnormal_wound_healing1.28396559
48MP0003191_abnormal_cellular_cholesterol1.27708827
49MP0004883_abnormal_blood_vessel1.25417370
50MP0003942_abnormal_urinary_system1.24583840
51MP0001270_distended_abdomen1.24291664
52MP0010386_abnormal_urinary_bladder1.20237350
53MP0001968_abnormal_touch/_nociception1.18373825
54MP0004510_myositis1.17497641
55MP0002733_abnormal_thermal_nociception1.15630808
56MP0010155_abnormal_intestine_physiology1.12911324
57MP0000733_abnormal_muscle_development1.12722787
58MP0000537_abnormal_urethra_morphology1.11126871
59MP0005166_decreased_susceptibility_to1.10510867
60MP0003283_abnormal_digestive_organ1.10045864
61MP0003879_abnormal_hair_cell1.08518772
62MP0004019_abnormal_vitamin_homeostasis1.07792712
63MP0000750_abnormal_muscle_regeneration1.07634605
64MP0003075_altered_response_to1.07516845
65MP0002734_abnormal_mechanical_nocicepti1.07267374
66MP0000749_muscle_degeneration1.07248619
67MP0005164_abnormal_response_to1.06690388
68MP0003300_gastrointestinal_ulcer1.05232329
69MP0001533_abnormal_skeleton_physiology1.04663516
70MP0002139_abnormal_hepatobiliary_system1.04531053
71MP0001177_atelectasis1.03909147
72MP0005171_absent_coat_pigmentation1.01866570
73MP0002133_abnormal_respiratory_system1.01081942
74MP0005388_respiratory_system_phenotype1.01081942
75MP0000163_abnormal_cartilage_morphology1.00909469
76MP0004084_abnormal_cardiac_muscle1.00128218
77MP0003115_abnormal_respiratory_system0.98655777
78MP0002933_joint_inflammation0.98615130
79MP0003329_amyloid_beta_deposits0.98314058
80MP0010234_abnormal_vibrissa_follicle0.97352602
81MP0001666_abnormal_nutrient_absorption0.96362185
82MP0002736_abnormal_nociception_after0.95948259
83MP0005670_abnormal_white_adipose0.95275008
84MP0000681_abnormal_thyroid_gland0.95168263
85MP0003448_altered_tumor_morphology0.95065229
86MP0003303_peritoneal_inflammation0.94916298
87MP0004947_skin_inflammation0.94543187
88MP0002282_abnormal_trachea_morphology0.92719538
89MP0001849_ear_inflammation0.91045892
90MP0000467_abnormal_esophagus_morphology0.90991858
91MP0005595_abnormal_vascular_smooth0.90734075
92MP0000538_abnormal_urinary_bladder0.90389342
93MP0002115_abnormal_skeleton_extremities0.90354927
94MP0004782_abnormal_surfactant_physiolog0.89394070
95MP0005501_abnormal_skin_physiology0.88875728
96MP0004264_abnormal_extraembryonic_tissu0.87912077
97MP0004036_abnormal_muscle_relaxation0.87723024
98MP0001348_abnormal_lacrimal_gland0.87568686
99MP0000759_abnormal_skeletal_muscle0.87535195
100MP0008260_abnormal_autophagy0.85810664
101MP0005167_abnormal_blood-brain_barrier0.85251412
102MP0005390_skeleton_phenotype0.85221530
103MP0000003_abnormal_adipose_tissue0.85000483
104MP0005367_renal/urinary_system_phenotyp0.84690673
105MP0000516_abnormal_urinary_system0.84690673
106MP0000747_muscle_weakness0.84488498
107MP0000049_abnormal_middle_ear0.81315839
108MP0010771_integument_phenotype0.80469685
109MP0000762_abnormal_tongue_morphology0.80144592
110MP0000428_abnormal_craniofacial_morphol0.79994551
111MP0002168_other_aberrant_phenotype0.79907953
112MP0002249_abnormal_larynx_morphology0.79832326
113MP0004484_altered_response_of0.79791696
114MP0000858_altered_metastatic_potential0.78836206
115MP0002234_abnormal_pharynx_morphology0.78598573
116MP0008004_abnormal_stomach_pH0.78105161
117MP0002998_abnormal_bone_remodeling0.77898413
118MP0004087_abnormal_muscle_fiber0.77429068
119MP0002877_abnormal_melanocyte_morpholog0.77206940
120MP0010352_gastrointestinal_tract_polyps0.76931532
121MP0003172_abnormal_lysosome_physiology0.76081719
122* MP0001970_abnormal_pain_threshold0.75575315
123MP0002909_abnormal_adrenal_gland0.75501198
124MP0000477_abnormal_intestine_morphology0.74029829
125MP0002089_abnormal_postnatal_growth/wei0.72819514
126MP0000604_amyloidosis0.72604621
127MP0001216_abnormal_epidermal_layer0.72549653
128MP0005451_abnormal_body_composition0.72540237
129MP0003795_abnormal_bone_structure0.72402965
130MP0001243_abnormal_dermal_layer0.72385000
131MP0006082_CNS_inflammation0.72149079
132MP0000343_altered_response_to0.71854498
133MP0000249_abnormal_blood_vessel0.71170103
134MP0004145_abnormal_muscle_electrophysio0.71126539
135MP0005369_muscle_phenotype0.70910808
136MP0005165_increased_susceptibility_to0.70466035
137MP0005375_adipose_tissue_phenotype0.70366679
138MP0006138_congestive_heart_failure0.70161070
139MP0005620_abnormal_muscle_contractility0.70061525
140MP0000462_abnormal_digestive_system0.68302078
141MP0001664_abnormal_digestion0.68018944
142MP0001756_abnormal_urination0.67620773
143MP0005381_digestive/alimentary_phenotyp0.67320842
144MP0003634_abnormal_glial_cell0.66145686
145MP0005365_abnormal_bile_salt0.65205949

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.83606329
2Protrusio acetabuli (HP:0003179)5.64549587
3Broad metatarsal (HP:0001783)4.47378457
4Aortic dissection (HP:0002647)4.44717806
5Aortic aneurysm (HP:0004942)4.29287163
6Atrophic scars (HP:0001075)4.01042469
7Ankle contracture (HP:0006466)3.92771375
8Cerebral aneurysm (HP:0004944)3.86094165
9Bladder diverticulum (HP:0000015)3.77835956
10Shallow orbits (HP:0000586)3.75956671
11Type 1 muscle fiber predominance (HP:0003803)3.51842951
12Systemic lupus erythematosus (HP:0002725)3.38772524
13Vascular tortuosity (HP:0004948)3.36290198
14Fragile skin (HP:0001030)3.31531628
15Increased connective tissue (HP:0009025)3.16842029
16Dilatation of the ascending aorta (HP:0005111)3.15347115
17Soft skin (HP:0000977)3.13114959
18Arterial tortuosity (HP:0005116)3.12918604
19Wormian bones (HP:0002645)3.05970573
20Spinal rigidity (HP:0003306)3.05839452
21Malnutrition (HP:0004395)3.04002437
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.02779659
23Increased variability in muscle fiber diameter (HP:0003557)2.86416162
24Mitral valve prolapse (HP:0001634)2.78185107
25Bowel diverticulosis (HP:0005222)2.69100645
26Abnormality of dentin (HP:0010299)2.68175489
27Peritonitis (HP:0002586)2.65647209
28Wrist flexion contracture (HP:0001239)2.63390012
29Mildly elevated creatine phosphokinase (HP:0008180)2.63284555
30Spondylolisthesis (HP:0003302)2.61135262
31Hyporeflexia of lower limbs (HP:0002600)2.60356638
32Follicular hyperkeratosis (HP:0007502)2.58740881
33Distal arthrogryposis (HP:0005684)2.56678646
34Blue sclerae (HP:0000592)2.51063108
35Hyperextensible skin (HP:0000974)2.49915001
36Abnormality of skeletal muscle fiber size (HP:0012084)2.49058061
37Bronchomalacia (HP:0002780)2.46039792
38Right ventricular cardiomyopathy (HP:0011663)2.45770860
39Abnormality of proline metabolism (HP:0010907)2.43609357
40Hydroxyprolinuria (HP:0003080)2.43609357
41Cervical subluxation (HP:0003308)2.42939692
42Abnormality of complement system (HP:0005339)2.41200616
43Axonal loss (HP:0003447)2.40523634
44Dysostosis multiplex (HP:0000943)2.40487573
45Vertebral compression fractures (HP:0002953)2.37200966
46Striae distensae (HP:0001065)2.32526022
47Aneurysm (HP:0002617)2.31957253
48Camptodactyly of toe (HP:0001836)2.31679818
49Abnormality of glycolipid metabolism (HP:0010969)2.29435366
50Abnormality of liposaccharide metabolism (HP:0010968)2.29435366
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.29435366
52Round ear (HP:0100830)2.27446371
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.26828703
54Osteolytic defects of the hand bones (HP:0009699)2.26828703
55Neurofibrillary tangles (HP:0002185)2.22025544
56Hypoventilation (HP:0002791)2.19832368
57Joint stiffness (HP:0001387)2.19798141
58Long toe (HP:0010511)2.18309660
59Emphysema (HP:0002097)2.17109124
60Genu recurvatum (HP:0002816)2.14191066
61Obstructive sleep apnea (HP:0002870)2.13916339
62Elbow flexion contracture (HP:0002987)2.13736471
63Hyperparathyroidism (HP:0000843)2.12910414
64Muscle fiber splitting (HP:0003555)2.11011014
65Ulnar claw (HP:0001178)2.10958968
66Ulnar bowing (HP:0003031)2.09916921
67Urinary glycosaminoglycan excretion (HP:0003541)2.09849008
68Mucopolysacchariduria (HP:0008155)2.09849008
69Abnormality of the Achilles tendon (HP:0005109)2.08425315
70Overgrowth (HP:0001548)2.08247895
71Neonatal short-limb short stature (HP:0008921)2.07549286
72Wide anterior fontanel (HP:0000260)2.06497868
73Scapular winging (HP:0003691)2.05994911
74Distal lower limb amyotrophy (HP:0008944)2.05436742
75Flat cornea (HP:0007720)2.04800314
76Deviation of the hallux (HP:0010051)2.04745090
77Pulmonary artery stenosis (HP:0004415)2.03530741
78Short hallux (HP:0010109)2.03327195
79Nuclear cataract (HP:0100018)2.02976797
80Abnormality of polysaccharide metabolism (HP:0011012)2.02965729
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02965729
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02965729
83Distal lower limb muscle weakness (HP:0009053)2.01946634
84Abnormality of the nasal mucosa (HP:0000433)2.01625203
85Complement deficiency (HP:0004431)2.01536805
86Difficulty climbing stairs (HP:0003551)2.01348191
87Knee flexion contracture (HP:0006380)2.01228789
88Slender build (HP:0001533)2.00174366
89Mitral regurgitation (HP:0001653)1.99052146
90Distal upper limb amyotrophy (HP:0007149)1.99031033
91Upper limb amyotrophy (HP:0009129)1.99031033
92Hypercortisolism (HP:0001578)1.98437131
93Buphthalmos (HP:0000557)1.97726637
94Myotonia (HP:0002486)1.97117385
95Redundant skin (HP:0001582)1.95348522
96Joint laxity (HP:0001388)1.95275020
97Coxa vara (HP:0002812)1.94935158
98Tarsal synostosis (HP:0008368)1.94105344
99Abnormality of the acetabulum (HP:0003170)1.91978135
100Alopecia of scalp (HP:0002293)1.91802665
101Biconcave vertebral bodies (HP:0004586)1.91530975
102Natal tooth (HP:0000695)1.89934251
103Achilles tendon contracture (HP:0001771)1.89674488
104Aplasia/Hypoplasia of the hallux (HP:0008362)1.89590208
105Ileus (HP:0002595)1.89462316
106Venous abnormality (HP:0002624)1.88333101
107Hand muscle atrophy (HP:0009130)1.88249483
108Abnormal delivery (HP:0001787)1.87671635
109Hallux valgus (HP:0001822)1.86928342
110Turricephaly (HP:0000262)1.86876210
111Flat acetabular roof (HP:0003180)1.86775848
112Absent phalangeal crease (HP:0006109)1.85895536
113Renal duplication (HP:0000075)1.85806498
114Interstitial pulmonary disease (HP:0006530)1.85126892
115Short nail (HP:0001799)1.84593066
116Glomerulonephritis (HP:0000099)1.81597878
117Nephritis (HP:0000123)1.80993385
118Spinal cord compression (HP:0002176)1.79745333
119Mesangial abnormality (HP:0001966)1.79594186
120Stridor (HP:0010307)1.79520006
121Generalized amyotrophy (HP:0003700)1.76867332
122Absent frontal sinuses (HP:0002688)1.76660400
123Cerebral inclusion bodies (HP:0100314)1.76629700
124Abnormality of the distal phalanges of the toes (HP:0010182)1.75287400
125Aplasia involving bones of the upper limbs (HP:0009823)1.75039186
126Aplasia of the phalanges of the hand (HP:0009802)1.75039186
127Aplasia involving bones of the extremities (HP:0009825)1.75039186
128Congenital glaucoma (HP:0001087)1.73993559
129Radial bowing (HP:0002986)1.73913335
130Bowing of the arm (HP:0006488)1.73887983
131Bowed forearm bones (HP:0003956)1.73887983
132Thin bony cortex (HP:0002753)1.73858148
133Venous insufficiency (HP:0005293)1.73088051
134Osteoarthritis (HP:0002758)1.72976799
135J-shaped sella turcica (HP:0002680)1.72728913
136Osteopenia (HP:0000938)1.72151253
137Neoplasm of the heart (HP:0100544)1.72008957
138Hyperacusis (HP:0010780)1.71259327
139Inguinal hernia (HP:0000023)1.70174697
140Aortic regurgitation (HP:0001659)1.68887566
141Synostosis involving bones of the feet (HP:0009140)1.67821321
142Synostosis involving bones of the lower limbs (HP:0009138)1.67821321
143Disproportionate tall stature (HP:0001519)1.67787556
144Flexion contracture of toe (HP:0005830)1.67588271
145Joint contractures involving the joints of the feet (HP:0100492)1.67588271
146Action tremor (HP:0002345)1.67048333
147Abnormality of carpal bone ossification (HP:0006257)1.66601020
148Femoral bowing (HP:0002980)1.65827520
149Supranuclear gaze palsy (HP:0000605)1.65510112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.70382577
2TTN2.83916203
3LATS22.73271947
4DDR22.72783760
5EPHB22.62916701
6KSR22.59686005
7NTRK12.56090644
8MAP3K22.55298308
9LMTK22.50303245
10PDGFRA2.46855234
11MYLK2.17166809
12FER2.16572998
13PRPF4B2.13716232
14ERN12.09317461
15LIMK12.09132536
16RIPK12.02905340
17TGFBR21.78299656
18PTK2B1.76509920
19MAPKAPK31.68518722
20EPHA31.63502852
21TESK11.60271582
22RET1.57448227
23DMPK1.57369016
24MAP3K91.55463614
25PKN21.50571114
26PTK21.49650051
27MAP2K11.47915358
28IRAK31.46443447
29GRK51.38969308
30PRKD31.37836624
31PAK61.37781653
32PAK31.33667302
33ICK1.33425850
34EPHB11.29115600
35MAP3K61.28696645
36NTRK31.28124521
37BMX1.26348742
38LRRK21.24265474
39ABL21.23293896
40PAK21.21335791
41SMG11.17936989
42LATS11.17698274
43ARAF1.08867288
44MINK11.08809054
45MAP3K111.07132646
46NME21.06461735
47PHKG11.05569244
48PHKG21.05569244
49PTK61.03995676
50TAOK21.03938519
51MAP3K11.03888068
52MST1R1.03529209
53DAPK21.02593874
54ROCK21.02341785
55ROCK11.01058881
56ILK0.99997032
57MAP2K20.96317121
58PAK40.90596938
59MARK20.90118891
60MET0.89612271
61PIK3CG0.88380657
62FGFR20.87707492
63CAMKK10.86567028
64MOS0.86328854
65TAOK10.85192595
66CDC42BPA0.84651682
67EPHA40.83328575
68TBK10.81226103
69FGFR40.78716051
70TIE10.75442706
71MAPKAPK50.74963624
72PRKD10.74847058
73PDGFRB0.74776605
74PRKCH0.73846611
75MAPK70.73207531
76SIK10.72818647
77MAP3K130.72759896
78RPS6KA20.69077147
79TYK20.67478607
80ACVR1B0.67232364
81MAP3K70.67174131
82FGFR10.67039798
83PIM20.66790147
84TYRO30.64815941
85STK380.64712905
86FRK0.64155737
87TRPM70.59674608
88ZAP700.58983575
89MATK0.56738500
90MAP3K30.56319631
91DAPK30.56292371
92RPS6KL10.56096943
93RPS6KC10.56096943
94MTOR0.54726368
95CDK140.53210022
96WNK10.51964212
97NEK90.51937868
98PRKG20.51068807
99TESK20.50882454
100MAP2K30.50870173
101KIT0.50709400
102SRC0.50374556
103CDK50.49042705
104BRAF0.48743400
105EEF2K0.48417155
106JAK10.46957191
107TGFBR10.46323007
108MAP2K60.43967384
109PAK10.43501693
110PRKCE0.43125217
111FGFR30.42276706
112CAMK2G0.41788236
113NME10.41368441
114CAMKK20.41252083
115HIPK20.40375392
116MAPK120.39394031
117GSK3A0.38393704
118CDK150.38354216
119PDPK10.37748375
120MAPK40.37575101
121PRKD20.37071750
122RPS6KA60.36878550
123MAP3K40.36247602
124AKT30.36025816
125PDK10.35953921
126JAK30.35946906
127CAMK2B0.35566729
128CDK180.34703091
129KSR10.33396041
130CDK11A0.32153729
131PLK20.31290242
132PIK3CA0.30850292
133ADRBK10.30643552
134ERBB20.29956444
135CAMK2D0.29748836
136EPHA20.28132496

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.15737095
2ECM-receptor interaction_Homo sapiens_hsa045122.63226999
3Other glycan degradation_Homo sapiens_hsa005112.38744268
4Renin-angiotensin system_Homo sapiens_hsa046142.13717554
5Focal adhesion_Homo sapiens_hsa045101.95871607
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.94595234
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84208092
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81336025
9Protein digestion and absorption_Homo sapiens_hsa049741.75531067
10Fat digestion and absorption_Homo sapiens_hsa049751.69687780
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67921038
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.67256910
13Dilated cardiomyopathy_Homo sapiens_hsa054141.66027292
14Sulfur metabolism_Homo sapiens_hsa009201.61772822
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.60744919
16Amoebiasis_Homo sapiens_hsa051461.57343464
17Proteoglycans in cancer_Homo sapiens_hsa052051.55042749
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54748017
19Fructose and mannose metabolism_Homo sapiens_hsa000511.53449050
20Galactose metabolism_Homo sapiens_hsa000521.45014284
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41622752
22Vitamin digestion and absorption_Homo sapiens_hsa049771.38046383
23Arginine biosynthesis_Homo sapiens_hsa002201.36669889
24Bladder cancer_Homo sapiens_hsa052191.32228399
25Histidine metabolism_Homo sapiens_hsa003401.29359727
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.28267269
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27923965
28GnRH signaling pathway_Homo sapiens_hsa049121.25560366
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25255747
30Synaptic vesicle cycle_Homo sapiens_hsa047211.25185864
31Hippo signaling pathway_Homo sapiens_hsa043901.23887687
32Salivary secretion_Homo sapiens_hsa049701.23020375
33Gastric acid secretion_Homo sapiens_hsa049711.20366516
34Glioma_Homo sapiens_hsa052141.20117514
35Adherens junction_Homo sapiens_hsa045201.19138865
36Melanogenesis_Homo sapiens_hsa049161.18896442
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18157210
38PPAR signaling pathway_Homo sapiens_hsa033201.15037412
39Gap junction_Homo sapiens_hsa045401.14809683
40Axon guidance_Homo sapiens_hsa043601.12839107
41VEGF signaling pathway_Homo sapiens_hsa043701.09605170
42Pertussis_Homo sapiens_hsa051331.09501450
43Thyroid hormone synthesis_Homo sapiens_hsa049181.09300915
44Estrogen signaling pathway_Homo sapiens_hsa049151.08725118
45Insulin secretion_Homo sapiens_hsa049111.06472143
46Renin secretion_Homo sapiens_hsa049241.06300735
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05045391
48Bile secretion_Homo sapiens_hsa049761.04976140
49Oxytocin signaling pathway_Homo sapiens_hsa049211.03121542
50Rap1 signaling pathway_Homo sapiens_hsa040151.02426589
51Dorso-ventral axis formation_Homo sapiens_hsa043201.01055520
52Hedgehog signaling pathway_Homo sapiens_hsa043401.00171445
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99411444
54Circadian entrainment_Homo sapiens_hsa047130.98747344
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98724993
56Basal cell carcinoma_Homo sapiens_hsa052170.98146589
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97326486
58Tight junction_Homo sapiens_hsa045300.96906557
59* TGF-beta signaling pathway_Homo sapiens_hsa043500.95736199
60Melanoma_Homo sapiens_hsa052180.95028040
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95022243
62Chronic myeloid leukemia_Homo sapiens_hsa052200.92009638
63PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90694276
64Long-term potentiation_Homo sapiens_hsa047200.90253082
65Taste transduction_Homo sapiens_hsa047420.90252693
66Vibrio cholerae infection_Homo sapiens_hsa051100.90037240
67Cholinergic synapse_Homo sapiens_hsa047250.89529791
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.89485229
69Sphingolipid metabolism_Homo sapiens_hsa006000.87309899
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83659758
71Renal cell carcinoma_Homo sapiens_hsa052110.82903586
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.82747862
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81184677
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.81128501
75Dopaminergic synapse_Homo sapiens_hsa047280.81003985
76Endocytosis_Homo sapiens_hsa041440.80734589
77Platelet activation_Homo sapiens_hsa046110.79811060
78Endometrial cancer_Homo sapiens_hsa052130.79397883
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.78196403
80Olfactory transduction_Homo sapiens_hsa047400.76409896
81Salmonella infection_Homo sapiens_hsa051320.76116589
82Arginine and proline metabolism_Homo sapiens_hsa003300.75705392
83Lysosome_Homo sapiens_hsa041420.75519692
84Long-term depression_Homo sapiens_hsa047300.74193730
85Notch signaling pathway_Homo sapiens_hsa043300.74032231
86Ras signaling pathway_Homo sapiens_hsa040140.73821384
87cAMP signaling pathway_Homo sapiens_hsa040240.73420390
88Mineral absorption_Homo sapiens_hsa049780.71815163
89Insulin signaling pathway_Homo sapiens_hsa049100.71728991
90Phagosome_Homo sapiens_hsa041450.71573326
91Pancreatic cancer_Homo sapiens_hsa052120.71448353
92TNF signaling pathway_Homo sapiens_hsa046680.71178541
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71075472
94Calcium signaling pathway_Homo sapiens_hsa040200.70981391
95Arachidonic acid metabolism_Homo sapiens_hsa005900.70637907
96Prion diseases_Homo sapiens_hsa050200.70295462
97Thyroid cancer_Homo sapiens_hsa052160.69860214
98Amphetamine addiction_Homo sapiens_hsa050310.69190974
99HIF-1 signaling pathway_Homo sapiens_hsa040660.69043474
100Pathways in cancer_Homo sapiens_hsa052000.68522519
101Wnt signaling pathway_Homo sapiens_hsa043100.68465460
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68141619
103Starch and sucrose metabolism_Homo sapiens_hsa005000.66272181
104Staphylococcus aureus infection_Homo sapiens_hsa051500.66262999
105Glutamatergic synapse_Homo sapiens_hsa047240.63863877
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63588205
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63485198
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63230418
109mTOR signaling pathway_Homo sapiens_hsa041500.63039789
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.62969961
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.62050156
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61904034
113Cocaine addiction_Homo sapiens_hsa050300.61660803
114Type II diabetes mellitus_Homo sapiens_hsa049300.61538120
115Pancreatic secretion_Homo sapiens_hsa049720.61321884
116Phenylalanine metabolism_Homo sapiens_hsa003600.61278636
117Hepatitis C_Homo sapiens_hsa051600.61122110
118Small cell lung cancer_Homo sapiens_hsa052220.60860313
119MAPK signaling pathway_Homo sapiens_hsa040100.60181615
120ErbB signaling pathway_Homo sapiens_hsa040120.59684286
121Toxoplasmosis_Homo sapiens_hsa051450.59364704
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59080606
123Malaria_Homo sapiens_hsa051440.58116344
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.57734659
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56659845
126Cardiac muscle contraction_Homo sapiens_hsa042600.56171134
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53559916
128Glutathione metabolism_Homo sapiens_hsa004800.53199067
129Complement and coagulation cascades_Homo sapiens_hsa046100.51316927
130Glycerolipid metabolism_Homo sapiens_hsa005610.50604445
131Sulfur relay system_Homo sapiens_hsa041220.50341361
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49189153
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46408378
134Tyrosine metabolism_Homo sapiens_hsa003500.46352563
135Insulin resistance_Homo sapiens_hsa049310.46226411
136Osteoclast differentiation_Homo sapiens_hsa043800.45066211
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44845935
138Pentose phosphate pathway_Homo sapiens_hsa000300.41783907

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