NBN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.94938989
2regulation of interferon-alpha production (GO:0032647)4.76301514
3DNA strand elongation (GO:0022616)4.70917236
4telomere maintenance via semi-conservative replication (GO:0032201)4.60048572
5positive regulation of interferon-alpha production (GO:0032727)4.58805325
6response to peptidoglycan (GO:0032494)4.53458699
7DNA unwinding involved in DNA replication (GO:0006268)4.46087379
8maturation of SSU-rRNA (GO:0030490)4.30857965
9telomere maintenance via recombination (GO:0000722)4.27044073
10ribosomal small subunit assembly (GO:0000028)4.14946297
11DNA replication initiation (GO:0006270)4.13788352
12mitotic recombination (GO:0006312)4.05637165
13regulation of vitamin D biosynthetic process (GO:0060556)3.99183982
14DNA deamination (GO:0045006)3.98947595
15chromatin remodeling at centromere (GO:0031055)3.95077321
16regulation of T-helper 1 cell differentiation (GO:0045625)3.94505055
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92123570
18CENP-A containing nucleosome assembly (GO:0034080)3.84431036
19negative regulation of interleukin-12 production (GO:0032695)3.78308312
20DNA replication checkpoint (GO:0000076)3.72958187
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72885201
22nucleobase biosynthetic process (GO:0046112)3.72863431
23nuclear pore organization (GO:0006999)3.70779024
24regulation of interferon-beta biosynthetic process (GO:0045357)3.68308073
25positive regulation of interferon-beta production (GO:0032728)3.67759139
26kinetochore organization (GO:0051383)3.67340382
27formation of translation preinitiation complex (GO:0001731)3.59385049
28purine nucleobase biosynthetic process (GO:0009113)3.56943498
29nuclear pore complex assembly (GO:0051292)3.55986744
30folic acid-containing compound biosynthetic process (GO:0009396)3.54063439
31cellular response to interferon-alpha (GO:0035457)3.53148458
32telomere maintenance via telomere lengthening (GO:0010833)3.52723190
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.52354409
34mitotic metaphase plate congression (GO:0007080)3.48603937
35cellular response to type I interferon (GO:0071357)3.48056576
36type I interferon signaling pathway (GO:0060337)3.48056576
37neutrophil activation involved in immune response (GO:0002283)3.45475714
38positive regulation by symbiont of host defense response (GO:0052509)3.44045000
39modulation by symbiont of host defense response (GO:0052031)3.44045000
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44045000
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44045000
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.44045000
43modulation by symbiont of host immune response (GO:0052553)3.44045000
44IMP biosynthetic process (GO:0006188)3.42958621
45response to type I interferon (GO:0034340)3.40867083
46detection of molecule of bacterial origin (GO:0032490)3.40732776
47ribosomal large subunit biogenesis (GO:0042273)3.39265452
48DNA replication-independent nucleosome assembly (GO:0006336)3.38991657
49DNA replication-independent nucleosome organization (GO:0034724)3.38991657
50positive regulation of gamma-delta T cell activation (GO:0046645)3.38934143
51T-helper 1 type immune response (GO:0042088)3.31495456
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27462642
53mitotic nuclear envelope disassembly (GO:0007077)3.26868573
54macrophage activation involved in immune response (GO:0002281)3.25431552
55metaphase plate congression (GO:0051310)3.22373197
56DNA replication-dependent nucleosome assembly (GO:0006335)3.18749162
57DNA replication-dependent nucleosome organization (GO:0034723)3.18749162
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15550994
59regulation of vitamin metabolic process (GO:0030656)3.15120945
60response to interferon-alpha (GO:0035455)3.14062023
61positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.13462603
62translational termination (GO:0006415)3.13032868
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11496345
64regulation of cytokine secretion involved in immune response (GO:0002739)3.10438346
65viral transcription (GO:0019083)3.10023066
66kinetochore assembly (GO:0051382)3.08721520
67histone exchange (GO:0043486)3.08616387
68mitotic chromosome condensation (GO:0007076)3.08201135
69protein localization to kinetochore (GO:0034501)3.07647352
70IMP metabolic process (GO:0046040)3.06356500
71pteridine-containing compound biosynthetic process (GO:0042559)3.04768735
72attachment of spindle microtubules to kinetochore (GO:0008608)3.04277849
73ribosomal small subunit biogenesis (GO:0042274)3.03428820
74ribonucleoprotein complex biogenesis (GO:0022613)3.01057188
75nuclear envelope disassembly (GO:0051081)2.98841995
76membrane disassembly (GO:0030397)2.98841995
77regulation of response to interferon-gamma (GO:0060330)2.98371644
78hepatocyte apoptotic process (GO:0097284)2.97601861
79* DNA geometric change (GO:0032392)2.96927898
80* DNA duplex unwinding (GO:0032508)2.96249648
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.96211645
82positive regulation of toll-like receptor signaling pathway (GO:0034123)2.95430782
83establishment of chromosome localization (GO:0051303)2.95401945
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95213738
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94536930
86ribosome biogenesis (GO:0042254)2.93849463
87translational elongation (GO:0006414)2.91707271
88B cell mediated immunity (GO:0019724)2.91645710
89* telomere maintenance (GO:0000723)2.89658958
90regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.88639413
91negative regulation of viral genome replication (GO:0045071)2.88500267
92mitotic sister chromatid cohesion (GO:0007064)2.88009073
93* telomere organization (GO:0032200)2.87269409
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87017778
95regulation of interferon-beta production (GO:0032648)2.86566863
96immunoglobulin mediated immune response (GO:0016064)2.86316642
97cotranslational protein targeting to membrane (GO:0006613)2.84779580
98positive regulation of type 2 immune response (GO:0002830)2.84218654
99protein targeting to ER (GO:0045047)2.83975634
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83435624
101response to host immune response (GO:0052572)2.83435624
102interferon-gamma-mediated signaling pathway (GO:0060333)2.82394541
103pore complex assembly (GO:0046931)2.82118920
104regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.82086719
105protein localization to chromosome, centromeric region (GO:0071459)2.81906735
106necroptotic process (GO:0070266)2.79004504
107translesion synthesis (GO:0019985)2.76621067
108positive regulation of nitric oxide biosynthetic process (GO:0045429)2.76509582
109translational initiation (GO:0006413)2.75550278
110rRNA processing (GO:0006364)2.74954289
111intra-S DNA damage checkpoint (GO:0031573)2.74177498
112positive regulation of chemokine biosynthetic process (GO:0045080)2.73733613
113regulation of interleukin-12 production (GO:0032655)2.73045620
114cellular response to ethanol (GO:0071361)2.71964752
115germinal center formation (GO:0002467)2.71704192
116transcription-coupled nucleotide-excision repair (GO:0006283)2.71556214
117regulation of podosome assembly (GO:0071801)2.70968187
118positive regulation of keratinocyte differentiation (GO:0045618)2.70523326
119histone-serine phosphorylation (GO:0035404)2.69325224
120positive regulation of interleukin-12 production (GO:0032735)2.69103330
121meiotic chromosome segregation (GO:0045132)2.68711203
122establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67250682
123establishment of integrated proviral latency (GO:0075713)2.66454423
124protein localization to endoplasmic reticulum (GO:0070972)2.65004064
125postreplication repair (GO:0006301)2.64971210
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64267584
127regulation of chronic inflammatory response (GO:0002676)2.63536332
128response to protozoan (GO:0001562)2.63347438
129response to host (GO:0075136)2.63321741
130response to host defenses (GO:0052200)2.63321741
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63321741
132rRNA metabolic process (GO:0016072)2.63121107
133chromatin assembly or disassembly (GO:0006333)2.62715391
134regulation of type I interferon-mediated signaling pathway (GO:0060338)2.61693010
135defense response to protozoan (GO:0042832)2.61626005
136positive regulation of interleukin-6 production (GO:0032755)2.61387202
137regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.61300613
138regulation of interleukin-8 biosynthetic process (GO:0045414)2.59930388
139regulation of fever generation (GO:0031620)2.59794405
140regulation of chemokine biosynthetic process (GO:0045073)2.58675258
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58062125
142positive regulation of protein import into nucleus, translocation (GO:0033160)2.57167015
143mitotic sister chromatid segregation (GO:0000070)2.56983811
144folic acid metabolic process (GO:0046655)2.56741947
145regulation of T-helper cell differentiation (GO:0045622)2.56700695
146positive regulation of interleukin-10 production (GO:0032733)2.56202145
147positive regulation of T-helper cell differentiation (GO:0045624)2.56182043
148positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55400945
149spliceosomal snRNP assembly (GO:0000387)2.55332423
150granulocyte activation (GO:0036230)2.55236598
151tetrahydrofolate metabolic process (GO:0046653)2.54002723
152T cell migration (GO:0072678)2.53895823
153cellular response to lipopolysaccharide (GO:0071222)2.53714482
154response to muramyl dipeptide (GO:0032495)2.53416214
155regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.52447000
156ribosome assembly (GO:0042255)2.51896182
157DNA double-strand break processing (GO:0000729)2.51753424
158cellular response to molecule of bacterial origin (GO:0071219)2.51164215
159negative regulation of growth of symbiont in host (GO:0044130)2.50651599
160negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.50651599
161modulation of growth of symbiont involved in interaction with host (GO:0044144)2.50651599
162regulation of growth of symbiont in host (GO:0044126)2.50651599
163regulation of helicase activity (GO:0051095)2.50432605
164cell cycle G1/S phase transition (GO:0044843)2.50385610
165G1/S transition of mitotic cell cycle (GO:0000082)2.50385610
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49557467
167* somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49537694
168* somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49537694
169* isotype switching (GO:0045190)2.49537694
170positive regulation of NF-kappaB import into nucleus (GO:0042346)2.49461067
171* DNA conformation change (GO:0071103)2.48868372
172myeloid dendritic cell activation (GO:0001773)2.48289274
173regulation of nitric oxide biosynthetic process (GO:0045428)2.48267273
174mismatch repair (GO:0006298)2.48001061
1753-UTR-mediated mRNA stabilization (GO:0070935)2.47993724
176pseudouridine synthesis (GO:0001522)2.47272568
177positive regulation of Cdc42 GTPase activity (GO:0043089)2.47110100
178sister chromatid segregation (GO:0000819)2.46624559
179negative regulation of mitotic sister chromatid separation (GO:2000816)2.46563392
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46563392
181negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46563392
182negative regulation of sister chromatid segregation (GO:0033046)2.46563392
183spindle assembly checkpoint (GO:0071173)2.46549730
184DNA replication (GO:0006260)2.46419326
185regulation of NF-kappaB import into nucleus (GO:0042345)2.45849494
186neutrophil activation (GO:0042119)2.44752028
187response to dsRNA (GO:0043331)2.44362000
188regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43795511
189negative regulation of chromosome segregation (GO:0051985)2.43316838
190cellular component biogenesis (GO:0044085)2.42808172
191positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.42518936
192NIK/NF-kappaB signaling (GO:0038061)2.42380646
193defense response to virus (GO:0051607)2.42098379
194production of molecular mediator involved in inflammatory response (GO:0002532)2.41574442
195regulation of RIG-I signaling pathway (GO:0039535)2.41456085
196positive regulation of alpha-beta T cell proliferation (GO:0046641)2.41348293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.01717776
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.92546731
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60884891
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49339053
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45359978
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35277706
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.25979064
8GATA1_22025678_ChIP-Seq_K562_Human3.22197342
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87206468
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.81254432
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72249691
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71470207
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.66205646
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47040308
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.46002734
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45955817
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43984925
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43763424
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42278926
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.40942745
21AR_21909140_ChIP-Seq_LNCAP_Human2.37178636
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36153447
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.33274986
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32602849
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27331217
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26098246
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17211996
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16101101
29VDR_23849224_ChIP-Seq_CD4+_Human2.15056788
30XRN2_22483619_ChIP-Seq_HELA_Human2.05244242
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.05127729
32* E2F1_21310950_ChIP-Seq_MCF-7_Human2.04383932
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.04345450
34* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03566819
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94739595
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94353691
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92028993
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91814283
39ELK1_19687146_ChIP-ChIP_HELA_Human1.91394974
40FOXP3_21729870_ChIP-Seq_TREG_Human1.89714281
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88117865
42DCP1A_22483619_ChIP-Seq_HELA_Human1.83775358
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82483725
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70058211
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69504154
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65642435
47GABP_19822575_ChIP-Seq_HepG2_Human1.63124720
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62952161
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61553792
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.60808177
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60625166
52* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58545449
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58251230
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55513049
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54784395
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54283938
57TTF2_22483619_ChIP-Seq_HELA_Human1.53695719
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.51795636
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51429085
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47936917
61* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47916584
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47102697
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43907360
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42060773
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40786958
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40645270
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40356151
68* IRF8_22096565_ChIP-ChIP_GC-B_Human1.38182260
69PU_27001747_Chip-Seq_BMDM_Mouse1.37943244
70KDM5A_27292631_Chip-Seq_BREAST_Human1.36643667
71* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35973716
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35699706
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35589636
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33433577
75SCL_19346495_ChIP-Seq_HPC-7_Human1.31513333
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30971215
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29600961
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28742372
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28378581
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27549554
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27014326
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26276133
83TFEB_21752829_ChIP-Seq_HELA_Human1.25543240
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25485806
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25214417
86CIITA_25753668_ChIP-Seq_RAJI_Human1.23076152
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20235240
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19830418
89MYC_22102868_ChIP-Seq_BL_Human1.19564403
90ELF5_23300383_ChIP-Seq_T47D_Human1.18906740
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18349283
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16633161
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16284326
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16186099
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15993970
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14355161
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13213900
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11181836
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.10412952
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09821265
101SPI1_23547873_ChIP-Seq_NB4_Human1.09358374
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04047517
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04047517
104VDR_24787735_ChIP-Seq_THP-1_Human1.03654250
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02994357
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02980144
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02288073
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02089685
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01080031
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99429954
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98088365
112* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96226402
113YY1_21170310_ChIP-Seq_MESCs_Mouse0.95899804
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95544933
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94713263
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94333703
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93916587
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93333580
119SPI1_23127762_ChIP-Seq_K562_Human0.93168421
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93151819
121CLOCK_20551151_ChIP-Seq_293T_Human0.92898948
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90958331
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90740601
124MAF_26560356_Chip-Seq_TH1_Human0.89887066
125* ESR1_20079471_ChIP-ChIP_T-47D_Human0.89839218
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89493177
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89398423
128MYB_26560356_Chip-Seq_TH1_Human0.87774445
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87605678
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87548317
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87465316
132MYB_26560356_Chip-Seq_TH2_Human0.86806425
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86641520
134* GATA3_26560356_Chip-Seq_TH2_Human0.86077925
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85876599
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85341417
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84942128
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84916351
139* RUNX1_22412390_ChIP-Seq_EML_Mouse0.84537327
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84527630
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83891353
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82801801
143IRF8_21731497_ChIP-ChIP_J774_Mouse0.81932074
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81448911
145VDR_24763502_ChIP-Seq_THP-1_Human0.81421639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.33566593
2MP0003693_abnormal_embryo_hatching4.04143298
3* MP0010094_abnormal_chromosome_stability3.66054345
4* MP0004957_abnormal_blastocyst_morpholog3.23201369
5MP0008057_abnormal_DNA_replication3.16642337
6MP0003111_abnormal_nucleus_morphology2.87228641
7* MP0003077_abnormal_cell_cycle2.85654168
8MP0008058_abnormal_DNA_repair2.51986539
9MP0002148_abnormal_hypersensitivity_rea2.45279227
10MP0003806_abnormal_nucleotide_metabolis2.41835547
11MP0002396_abnormal_hematopoietic_system2.39137657
12MP0008007_abnormal_cellular_replicative2.33965523
13MP0005451_abnormal_body_composition2.30523448
14MP0006082_CNS_inflammation2.24616241
15MP0006054_spinal_hemorrhage2.10121554
16MP0003191_abnormal_cellular_cholesterol2.07733737
17MP0003300_gastrointestinal_ulcer1.95660257
18MP0002419_abnormal_innate_immunity1.93585354
19MP0003186_abnormal_redox_activity1.80937116
20MP0004808_abnormal_hematopoietic_stem1.79939108
21MP0001835_abnormal_antigen_presentation1.77522878
22MP0010352_gastrointestinal_tract_polyps1.75113356
23MP0005387_immune_system_phenotype1.74270701
24MP0001790_abnormal_immune_system1.74270701
25MP0002877_abnormal_melanocyte_morpholog1.71685146
26* MP0008932_abnormal_embryonic_tissue1.71673210
27MP0009697_abnormal_copulation1.63300353
28MP0004947_skin_inflammation1.63117495
29MP0003123_paternal_imprinting1.60935269
30MP0003786_premature_aging1.58732159
31MP0009764_decreased_sensitivity_to1.56668115
32MP0000490_abnormal_crypts_of1.54959554
33MP0003763_abnormal_thymus_physiology1.53625221
34MP0001730_embryonic_growth_arrest1.51889975
35MP0008877_abnormal_DNA_methylation1.51300179
36MP0001545_abnormal_hematopoietic_system1.50406154
37MP0005397_hematopoietic_system_phenotyp1.50406154
38* MP0000350_abnormal_cell_proliferation1.49353480
39MP0003448_altered_tumor_morphology1.47959752
40MP0009785_altered_susceptibility_to1.41927629
41MP0009840_abnormal_foam_cell1.41242570
42MP0008260_abnormal_autophagy1.41239023
43MP0001853_heart_inflammation1.41086321
44MP0002332_abnormal_exercise_endurance1.37965884
45MP0000569_abnormal_digit_pigmentation1.32955263
46MP0010234_abnormal_vibrissa_follicle1.31633214
47* MP0010307_abnormal_tumor_latency1.31100145
48MP0003453_abnormal_keratinocyte_physiol1.28376581
49MP0003221_abnormal_cardiomyocyte_apopto1.27794370
50MP0002139_abnormal_hepatobiliary_system1.27225951
51* MP0002019_abnormal_tumor_incidence1.26085038
52MP0005310_abnormal_salivary_gland1.23040341
53* MP0002398_abnormal_bone_marrow1.22295463
54MP0003183_abnormal_peptide_metabolism1.22104386
55MP0005058_abnormal_lysosome_morphology1.19670104
56* MP0000313_abnormal_cell_death1.18314961
57MP0003075_altered_response_to1.17836381
58MP0000465_gastrointestinal_hemorrhage1.15937201
59MP0001533_abnormal_skeleton_physiology1.15594622
60MP0006036_abnormal_mitochondrial_physio1.14692281
61MP0002166_altered_tumor_susceptibility1.14610551
62MP0000689_abnormal_spleen_morphology1.14506841
63* MP0005380_embryogenesis_phenotype1.12694752
64* MP0001672_abnormal_embryogenesis/_devel1.12694752
65MP0000685_abnormal_immune_system1.11871759
66* MP0003984_embryonic_growth_retardation1.11668584
67MP0009333_abnormal_splenocyte_physiolog1.09969894
68MP0005464_abnormal_platelet_physiology1.09953036
69MP0003941_abnormal_skin_development1.09636297
70MP0003943_abnormal_hepatobiliary_system1.08865938
71MP0008004_abnormal_stomach_pH1.08591025
72MP0003705_abnormal_hypodermis_morpholog1.08434193
73* MP0002088_abnormal_embryonic_growth/wei1.08361571
74* MP0002722_abnormal_immune_system1.07668930
75* MP0001697_abnormal_embryo_size1.06779610
76MP0003567_abnormal_fetal_cardiomyocyte1.05151122
77MP0005360_urolithiasis1.05143247
78MP0004147_increased_porphyrin_level1.04882664
79MP0003091_abnormal_cell_migration1.04323568
80* MP0002080_prenatal_lethality1.02647961
81* MP0000703_abnormal_thymus_morphology1.01280698
82MP0009379_abnormal_foot_pigmentation1.00510934
83MP0002006_tumorigenesis1.00438164
84* MP0002429_abnormal_blood_cell1.00321605
85MP0004185_abnormal_adipocyte_glucose0.98885878
86MP0005164_abnormal_response_to0.98286288
87MP0010030_abnormal_orbit_morphology0.97359967
88MP0005671_abnormal_response_to0.96636952
89* MP0001800_abnormal_humoral_immune0.96609222
90MP0010678_abnormal_skin_adnexa0.96012351
91MP0003656_abnormal_erythrocyte_physiolo0.95886304
92MP0003436_decreased_susceptibility_to0.95152167
93MP0010155_abnormal_intestine_physiology0.94525946
94MP0000598_abnormal_liver_morphology0.93766125
95MP0005621_abnormal_cell_physiology0.93734677
96MP0005365_abnormal_bile_salt0.93214098
97MP0003724_increased_susceptibility_to0.91333489
98* MP0000716_abnormal_immune_system0.90974091
99* MP0002452_abnormal_antigen_presenting0.90928042
100* MP0002086_abnormal_extraembryonic_tissu0.90552799
101MP0004197_abnormal_fetal_growth/weight/0.89351179
102MP0005166_decreased_susceptibility_to0.88933429
103MP0001764_abnormal_homeostasis0.87881990
104MP0001727_abnormal_embryo_implantation0.87638512
105MP0005085_abnormal_gallbladder_physiolo0.85599190
106* MP0002723_abnormal_immune_serum0.84878855
107MP0005319_abnormal_enzyme/_coenzyme0.84028769
108MP0005076_abnormal_cell_differentiation0.83762953
109* MP0002420_abnormal_adaptive_immunity0.83624248
110MP0004883_abnormal_blood_vessel0.83145978
111MP0004264_abnormal_extraembryonic_tissu0.82976321
112MP0002405_respiratory_system_inflammati0.81955114
113* MP0001819_abnormal_immune_cell0.81691854
114MP0005000_abnormal_immune_tolerance0.81518032
115MP0005023_abnormal_wound_healing0.80512895
116MP0001216_abnormal_epidermal_layer0.79603988
117MP0001873_stomach_inflammation0.79454282
118MP0004510_myositis0.79318330
119MP0005025_abnormal_response_to0.78657020
120MP0000371_diluted_coat_color0.78148124
121MP0003950_abnormal_plasma_membrane0.77982539
122MP0000609_abnormal_liver_physiology0.77658537
123MP0008469_abnormal_protein_level0.77016571
124MP0001191_abnormal_skin_condition0.75577859
125MP0002998_abnormal_bone_remodeling0.75247173
126MP0002009_preneoplasia0.74349974
127* MP0009763_increased_sensitivity_to0.74175101
128MP0001845_abnormal_inflammatory_respons0.74088080
129MP0003718_maternal_effect0.72631636
130MP0000858_altered_metastatic_potential0.69851429
131MP0005408_hypopigmentation0.68081898
132MP0000358_abnormal_cell_content/0.66616228
133MP0000343_altered_response_to0.65325754
134MP0005083_abnormal_biliary_tract0.64964324
135MP0002084_abnormal_developmental_patter0.63909531
136MP0009278_abnormal_bone_marrow0.63202885
137MP0004084_abnormal_cardiac_muscle0.63041918
138MP0003566_abnormal_cell_adhesion0.62519536
139* MP0002085_abnormal_embryonic_tissue0.62225288
140MP0003121_genomic_imprinting0.61511333

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.07733045
2Recurrent abscess formation (HP:0002722)3.84660043
3Reticulocytopenia (HP:0001896)3.81747712
4Abnormal number of erythroid precursors (HP:0012131)3.77967427
5Retrobulbar optic neuritis (HP:0100654)3.76385858
6Optic neuritis (HP:0100653)3.76385858
7Abnormality of cells of the erythroid lineage (HP:0012130)3.65939349
8Orchitis (HP:0100796)3.46237079
9Recurrent viral infections (HP:0004429)3.41683138
10Subacute progressive viral hepatitis (HP:0006572)3.37803187
11Abnormality of the anterior horn cell (HP:0006802)3.37696386
12Degeneration of anterior horn cells (HP:0002398)3.37696386
13Eczematoid dermatitis (HP:0000976)3.31376488
14Abnormality of liposaccharide metabolism (HP:0010968)3.27630274
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.27630274
16Abnormality of glycolipid metabolism (HP:0010969)3.27630274
17Papillary thyroid carcinoma (HP:0002895)3.26166415
18Thrombocytosis (HP:0001894)3.10916823
19Keratoconjunctivitis sicca (HP:0001097)3.04833228
20Birth length less than 3rd percentile (HP:0003561)3.04208766
21Mediastinal lymphadenopathy (HP:0100721)3.03752408
22Viral hepatitis (HP:0006562)3.02056736
23Aplastic anemia (HP:0001915)2.99915835
24Abnormality of macrophages (HP:0004311)2.99771424
25Myositis (HP:0100614)2.91897447
26Micronodular cirrhosis (HP:0001413)2.80581848
27Oral leukoplakia (HP:0002745)2.79939644
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79020822
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79020822
30Disinhibition (HP:0000734)2.78251181
31IgA deficiency (HP:0002720)2.76549354
32Thyroid carcinoma (HP:0002890)2.69465695
33Loss of speech (HP:0002371)2.64403385
34Generalized aminoaciduria (HP:0002909)2.64375672
35Keratoconjunctivitis (HP:0001096)2.63784138
36Colon cancer (HP:0003003)2.61640295
3711 pairs of ribs (HP:0000878)2.61450788
38Hepatic necrosis (HP:0002605)2.57954954
39Arterial thrombosis (HP:0004420)2.56714722
40Poikiloderma (HP:0001029)2.51772628
41* Abnormality of chromosome stability (HP:0003220)2.48457183
42Stomatitis (HP:0010280)2.47085372
43Pallor (HP:0000980)2.45688333
44Macrocytic anemia (HP:0001972)2.45607386
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.43726427
46Nausea (HP:0002018)2.42907590
47Chromsome breakage (HP:0040012)2.42140689
48Abnormality of pyrimidine metabolism (HP:0004353)2.41007182
49Agnosia (HP:0010524)2.40171144
50Vasculitis (HP:0002633)2.39976893
51Recurrent fungal infections (HP:0002841)2.39935572
52IgM deficiency (HP:0002850)2.38378993
53Colitis (HP:0002583)2.37174057
54Asymmetry of the thorax (HP:0001555)2.35853426
55Autoimmune thrombocytopenia (HP:0001973)2.33655400
56Hypoglycemic coma (HP:0001325)2.32550506
57Gangrene (HP:0100758)2.31511407
58* T lymphocytopenia (HP:0005403)2.30583293
59Entropion (HP:0000621)2.28763648
60Recurrent skin infections (HP:0001581)2.28591222
61Interstitial pulmonary disease (HP:0006530)2.27278399
62Absent frontal sinuses (HP:0002688)2.26860351
63Increased serum lactate (HP:0002151)2.26741378
64Selective tooth agenesis (HP:0001592)2.26090941
65Abnormality of the preputium (HP:0100587)2.24296760
66Abnormality of alanine metabolism (HP:0010916)2.23695224
67Hyperalaninemia (HP:0003348)2.23695224
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23695224
69Recurrent gram-negative bacterial infections (HP:0005420)2.23454247
70Encephalitis (HP:0002383)2.22253298
71* Abnormality of T cell number (HP:0011839)2.21869083
72Renal cortical cysts (HP:0000803)2.19938166
73Hepatocellular necrosis (HP:0001404)2.18210366
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.17928612
75Increased CSF lactate (HP:0002490)2.17811125
76Type I transferrin isoform profile (HP:0003642)2.17091351
77Curly hair (HP:0002212)2.17042095
78Osteomyelitis (HP:0002754)2.16872423
79Exertional dyspnea (HP:0002875)2.16217094
80Transitional cell carcinoma of the bladder (HP:0006740)2.16127500
81Uterine leiomyosarcoma (HP:0002891)2.16011521
82Leiomyosarcoma (HP:0100243)2.16011521
83Myelodysplasia (HP:0002863)2.15104866
84Meningitis (HP:0001287)2.13668725
85Carpal bone hypoplasia (HP:0001498)2.12854755
86Acute hepatic failure (HP:0006554)2.12441761
87Gastrointestinal infarctions (HP:0005244)2.11102777
88Lipid accumulation in hepatocytes (HP:0006561)2.10603527
89Increased IgM level (HP:0003496)2.10578571
90Fatigue (HP:0012378)2.09562141
91Bladder neoplasm (HP:0009725)2.09372642
92Bladder carcinoma (HP:0002862)2.09372642
93Reduced antithrombin III activity (HP:0001976)2.09362196
94Gingivitis (HP:0000230)2.08694667
95Stomach cancer (HP:0012126)2.06745184
96* Deep philtrum (HP:0002002)2.05898306
97Anorexia (HP:0002039)2.05872103
98Irregular epiphyses (HP:0010582)2.05548993
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.05387701
100Spinal cord lesions (HP:0100561)2.05216075
101Syringomyelia (HP:0003396)2.05216075
102Abnormal mitochondria in muscle tissue (HP:0008316)2.04448521
103Cutaneous melanoma (HP:0012056)2.03626398
104Abnormality of reticulocytes (HP:0004312)2.03402139
105Myocardial infarction (HP:0001658)2.03303433
106Pulmonary infiltrates (HP:0002113)2.03133319
107Cellulitis (HP:0100658)2.02698237
108Abnormality of fatty-acid metabolism (HP:0004359)2.01039690
109Insidious onset (HP:0003587)2.00883474
110Termporal pattern (HP:0011008)2.00883474
111Pancytopenia (HP:0001876)2.00176566
112Urticaria (HP:0001025)2.00071816
113Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99954643
114Microretrognathia (HP:0000308)1.99870233
115Hypobetalipoproteinemia (HP:0003563)1.98946545
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98677896
117Nephroblastoma (Wilms tumor) (HP:0002667)1.98353674
118Increased hepatocellular lipid droplets (HP:0006565)1.97507760
119Progressive external ophthalmoplegia (HP:0000590)1.96786796
120Meckel diverticulum (HP:0002245)1.94531211
121Periodontitis (HP:0000704)1.94483793
122Basal cell carcinoma (HP:0002671)1.93835421
123Embryonal renal neoplasm (HP:0011794)1.93122812
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92474485
125Small intestinal stenosis (HP:0012848)1.92085328
126Duodenal stenosis (HP:0100867)1.92085328
127Acute encephalopathy (HP:0006846)1.91287904
128Prostate neoplasm (HP:0100787)1.91263601
129Premature graying of hair (HP:0002216)1.91218645
130Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89694422
131Mitochondrial inheritance (HP:0001427)1.89676816
132Rough bone trabeculation (HP:0100670)1.89072756
133Abnormal protein glycosylation (HP:0012346)1.88387621
134Abnormal glycosylation (HP:0012345)1.88387621
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88387621
136Abnormal protein N-linked glycosylation (HP:0012347)1.88387621
137Acute necrotizing encephalopathy (HP:0006965)1.88357222
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.87284358
139Abnormal hemoglobin (HP:0011902)1.87147581
140Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85925150
141Granulocytopenia (HP:0001913)1.85169487
142Volvulus (HP:0002580)1.84084064
143Increased muscle lipid content (HP:0009058)1.83811495
144Neoplasm of the tracheobronchial system (HP:0100552)1.83420010
145Cleft eyelid (HP:0000625)1.82874761
146Chronic mucocutaneous candidiasis (HP:0002728)1.82845621
147Recurrent cutaneous fungal infections (HP:0011370)1.82845621
148Vacuolated lymphocytes (HP:0001922)1.82627934
149Osteolytic defects of the hand bones (HP:0009699)1.82476535
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.82476535
151* Autoimmune hemolytic anemia (HP:0001890)1.82231983
152* Medulloblastoma (HP:0002885)1.82006416
153Eosinophilia (HP:0001880)1.81358474
154Abnormality of the ileum (HP:0001549)1.80875117
155Short middle phalanx of the 5th finger (HP:0004220)1.80844454
156Cerebral edema (HP:0002181)1.80649439
157Increased intramyocellular lipid droplets (HP:0012240)1.80115961
158Multiple enchondromatosis (HP:0005701)1.79904434
159Squamous cell carcinoma (HP:0002860)1.79371388
160Neoplasm of head and neck (HP:0012288)1.78772877
161Esophageal neoplasm (HP:0100751)1.78772877
162Chest pain (HP:0100749)1.78474623
163Acute myeloid leukemia (HP:0004808)1.78349659
164Poor head control (HP:0002421)1.77508033
165Leukocytosis (HP:0001974)1.77146476
166Abnormality of T cell physiology (HP:0011840)1.76931881
167Abnormality of serum amino acid levels (HP:0003112)1.75660756
168Absent thumb (HP:0009777)1.74209904
169Gastrointestinal carcinoma (HP:0002672)1.74200076
170Malignant gastrointestinal tract tumors (HP:0006749)1.74200076
171Inflammation of the large intestine (HP:0002037)1.73928169
172Abnormality of the frontal sinuses (HP:0002687)1.73614183
173Abnormal spermatogenesis (HP:0008669)1.72960204
174Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72215470
175Dicarboxylic aciduria (HP:0003215)1.72215470
176Impulsivity (HP:0100710)1.70913138
177Lactic acidosis (HP:0003128)1.70051586
178Breast hypoplasia (HP:0003187)1.69562493
179Amaurosis fugax (HP:0100576)1.69251472
180Abnormality of DNA repair (HP:0003254)1.68868301
181* Sloping forehead (HP:0000340)1.67358469
182* Lymphoma (HP:0002665)1.67268529
183Hyperglycinemia (HP:0002154)1.67013465
184IgG deficiency (HP:0004315)1.64710958
185Respiratory difficulties (HP:0002880)1.64129015
186Exercise intolerance (HP:0003546)1.63894248
187Neoplasm of the colon (HP:0100273)1.63832173
188Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62654623
189Abnormality of the duodenum (HP:0002246)1.62471949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.78194428
2WEE13.23483035
3EIF2AK13.14991235
4BRSK23.12546041
5BMPR23.07178252
6BUB12.81815039
7ACVR1B2.45262465
8FLT32.37804155
9RIPK42.21567224
10MATK2.17867700
11STK162.08881094
12NME22.07224415
13EIF2AK32.01331513
14MST41.99563163
15NEK21.98814141
16MAP3K121.97838570
17SRPK11.87593299
18MKNK11.80789959
19NEK91.80543055
20VRK11.75347572
21TSSK61.72349815
22RPS6KA41.70906263
23PKN21.67544620
24PASK1.66880429
25JAK11.65308668
26TLK11.62847858
27PRPF4B1.59711516
28PLK41.55163013
29BCKDK1.51315576
30TGFBR11.50058954
31NEK11.47249829
32TTK1.45642698
33AURKB1.45169415
34* ATR1.43975570
35MKNK21.41799569
36PLK11.39222780
37SCYL21.39131859
38CDK41.37704700
39BLK1.37301419
40SIK31.35129882
41CLK11.35007362
42CDK81.30459539
43IRAK11.28173209
44IRAK21.27607028
45FGR1.26507258
46BRSK11.25779417
47MAP3K141.24036597
48CSK1.23573144
49CCNB11.18864399
50STK41.18505025
51TAOK21.18003313
52TBK11.13989979
53MAP3K101.13293985
54TEC1.12589226
55STK101.10756175
56CDK71.09035931
57TRIM281.07191745
58PLK31.03497642
59MAP4K11.01875443
60TAF11.01216298
61PIM20.99322466
62YES10.99209983
63KIT0.98231649
64PBK0.97352856
65DYRK30.97003769
66NUAK10.96831727
67RPS6KB20.96637237
68CDK60.96396847
69BCR0.95754077
70JAK20.95662312
71IKBKB0.95537616
72PDK30.94348011
73PDK40.94348011
74MAP2K30.93637150
75CHEK20.93329410
76JAK30.92878440
77PIM10.92346349
78KDR0.92164106
79EIF2AK20.89991793
80NEK60.87971651
81TYK20.86569917
82MAP3K80.82503717
83GRK70.80804538
84CHUK0.80481717
85BTK0.80191553
86CHEK10.77839849
87IRAK40.76556803
88PDK20.75103053
89IKBKE0.73690694
90MAP3K130.73400974
91RPS6KA50.73162703
92MAP3K10.72344614
93* ATM0.71466831
94MAP3K60.70401855
95TRIB30.70351279
96LRRK20.69748381
97TRPM70.68798390
98CSNK2A10.68529377
99FGFR30.67747943
100ZAK0.66624792
101LYN0.65653605
102MAP3K20.64644606
103STK30.64593050
104ZAP700.63470259
105ERBB30.62281003
106RAF10.62156733
107TGFBR20.62152633
108KSR10.61986740
109MELK0.60513290
110TESK10.60423763
111CSNK2A20.60035382
112PAK40.58717216
113ALK0.56243707
114TESK20.55755564
115STK240.53684751
116CDK20.53412458
117AURKA0.53046310
118FGFR40.52394810
119HCK0.52211276
120MARK30.50867291
121TXK0.50773370
122CDK120.50328782
123MAP3K30.50266714
124TTN0.50136273
125MAP3K50.49519994
126NLK0.49161795
127MST1R0.48541228
128RIPK10.45580698
129MAPKAPK30.45304241
130DDR20.41629111
131SYK0.40445504
132EEF2K0.40191224
133MOS0.39930125
134CSF1R0.39877338
135RPS6KB10.38922564
136PIK3CG0.37717587
137IRAK30.37710513
138MAPKAPK20.36016736
139CDK10.35321206

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04980357
2Mismatch repair_Homo sapiens_hsa034303.90229312
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.77821315
4Ribosome_Homo sapiens_hsa030102.73434300
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70681370
6Nucleotide excision repair_Homo sapiens_hsa034202.66715433
7* Homologous recombination_Homo sapiens_hsa034402.57857690
8One carbon pool by folate_Homo sapiens_hsa006702.50976640
9Spliceosome_Homo sapiens_hsa030402.44720533
10Base excision repair_Homo sapiens_hsa034102.39735751
11Proteasome_Homo sapiens_hsa030502.28167174
12Cell cycle_Homo sapiens_hsa041102.23112119
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18913237
14Pyrimidine metabolism_Homo sapiens_hsa002402.16711242
15RNA transport_Homo sapiens_hsa030132.12574757
16RNA polymerase_Homo sapiens_hsa030202.07744048
17Osteoclast differentiation_Homo sapiens_hsa043801.94957294
18TNF signaling pathway_Homo sapiens_hsa046681.92465076
19Non-homologous end-joining_Homo sapiens_hsa034501.79932561
20Malaria_Homo sapiens_hsa051441.73160290
21Graft-versus-host disease_Homo sapiens_hsa053321.71175538
22African trypanosomiasis_Homo sapiens_hsa051431.71041946
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70065294
24Tuberculosis_Homo sapiens_hsa051521.68512173
25Selenocompound metabolism_Homo sapiens_hsa004501.68046389
26Fanconi anemia pathway_Homo sapiens_hsa034601.64950581
27Asthma_Homo sapiens_hsa053101.64360653
28B cell receptor signaling pathway_Homo sapiens_hsa046621.61578083
29RNA degradation_Homo sapiens_hsa030181.50661040
30Rheumatoid arthritis_Homo sapiens_hsa053231.49753900
31Hepatitis C_Homo sapiens_hsa051601.47001073
32Toxoplasmosis_Homo sapiens_hsa051451.46632954
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.40039162
34Basal transcription factors_Homo sapiens_hsa030221.40002640
35Protein export_Homo sapiens_hsa030601.37565205
36Autoimmune thyroid disease_Homo sapiens_hsa053201.36829394
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.33585877
38Staphylococcus aureus infection_Homo sapiens_hsa051501.31999423
39Folate biosynthesis_Homo sapiens_hsa007901.30946048
40Pancreatic cancer_Homo sapiens_hsa052121.30801845
41Systemic lupus erythematosus_Homo sapiens_hsa053221.29511649
42Pertussis_Homo sapiens_hsa051331.26891352
43p53 signaling pathway_Homo sapiens_hsa041151.26300719
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25759509
45Type I diabetes mellitus_Homo sapiens_hsa049401.24656888
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24230304
47Acute myeloid leukemia_Homo sapiens_hsa052211.23961955
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17905704
49Herpes simplex infection_Homo sapiens_hsa051681.15908016
50Salmonella infection_Homo sapiens_hsa051321.14539490
51Antigen processing and presentation_Homo sapiens_hsa046121.13646060
52Legionellosis_Homo sapiens_hsa051341.13437631
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11791705
54Carbon metabolism_Homo sapiens_hsa012001.09385724
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.09088347
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.09016393
57Pentose phosphate pathway_Homo sapiens_hsa000301.08895566
58Purine metabolism_Homo sapiens_hsa002301.08887979
59Chronic myeloid leukemia_Homo sapiens_hsa052201.06613520
60Biosynthesis of amino acids_Homo sapiens_hsa012301.03190209
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00452479
62Non-small cell lung cancer_Homo sapiens_hsa052231.00037343
63Other glycan degradation_Homo sapiens_hsa005110.99664799
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96533060
65Propanoate metabolism_Homo sapiens_hsa006400.96391270
66Viral myocarditis_Homo sapiens_hsa054160.96017266
67Bladder cancer_Homo sapiens_hsa052190.95685384
68Prolactin signaling pathway_Homo sapiens_hsa049170.93029769
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92427292
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89725075
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89118623
72Chemokine signaling pathway_Homo sapiens_hsa040620.88574794
73Epstein-Barr virus infection_Homo sapiens_hsa051690.88193112
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84741062
75Glutathione metabolism_Homo sapiens_hsa004800.84634935
76Viral carcinogenesis_Homo sapiens_hsa052030.83214729
77Fatty acid degradation_Homo sapiens_hsa000710.82529062
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81018660
79Lysosome_Homo sapiens_hsa041420.80975498
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80833607
81Renal cell carcinoma_Homo sapiens_hsa052110.80529070
82Prostate cancer_Homo sapiens_hsa052150.80036647
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79949456
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78091830
85Pyruvate metabolism_Homo sapiens_hsa006200.77209147
86T cell receptor signaling pathway_Homo sapiens_hsa046600.74961026
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74043640
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72079039
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70502603
90mRNA surveillance pathway_Homo sapiens_hsa030150.69849992
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.68162875
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67965045
93Measles_Homo sapiens_hsa051620.67411448
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67354329
95Endometrial cancer_Homo sapiens_hsa052130.66394689
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65682079
97Vitamin B6 metabolism_Homo sapiens_hsa007500.64384798
98HTLV-I infection_Homo sapiens_hsa051660.64367843
99Parkinsons disease_Homo sapiens_hsa050120.63371754
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62863627
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61933499
102HIF-1 signaling pathway_Homo sapiens_hsa040660.60714532
103Sulfur relay system_Homo sapiens_hsa041220.58361340
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.58072317
105MicroRNAs in cancer_Homo sapiens_hsa052060.57960578
106Phagosome_Homo sapiens_hsa041450.56385909
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54895699
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54031083
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.53736722
110Huntingtons disease_Homo sapiens_hsa050160.53317615
111Primary immunodeficiency_Homo sapiens_hsa053400.53302238
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.52794990
113Amoebiasis_Homo sapiens_hsa051460.52541274
114Thyroid cancer_Homo sapiens_hsa052160.51950703
115Peroxisome_Homo sapiens_hsa041460.51844003
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50975112
117Fructose and mannose metabolism_Homo sapiens_hsa000510.50749355
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.50616178
119Colorectal cancer_Homo sapiens_hsa052100.49955213
120Leishmaniasis_Homo sapiens_hsa051400.49763551
121Allograft rejection_Homo sapiens_hsa053300.48437355
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48239137
123Apoptosis_Homo sapiens_hsa042100.48105669
124Proteoglycans in cancer_Homo sapiens_hsa052050.47810653
125Galactose metabolism_Homo sapiens_hsa000520.47634118
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45877258
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.45253734
128FoxO signaling pathway_Homo sapiens_hsa040680.44540706
129N-Glycan biosynthesis_Homo sapiens_hsa005100.43640351
130Tryptophan metabolism_Homo sapiens_hsa003800.42776682
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.42730795
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.42343691
133Influenza A_Homo sapiens_hsa051640.42257530
134Platelet activation_Homo sapiens_hsa046110.41701773
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40380617
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39413541
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38749484
138Hepatitis B_Homo sapiens_hsa051610.38500673
139Small cell lung cancer_Homo sapiens_hsa052220.38178122
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38032592
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.37389537
142Chemical carcinogenesis_Homo sapiens_hsa052040.37020659
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36844090
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36632360
145Metabolic pathways_Homo sapiens_hsa011000.36264048
146Hematopoietic cell lineage_Homo sapiens_hsa046400.35815731
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35750039
148Phenylalanine metabolism_Homo sapiens_hsa003600.32757653
149Oxidative phosphorylation_Homo sapiens_hsa001900.30994220
150Oocyte meiosis_Homo sapiens_hsa041140.30700095
151Tyrosine metabolism_Homo sapiens_hsa003500.29864308
152Shigellosis_Homo sapiens_hsa051310.25562695
153beta-Alanine metabolism_Homo sapiens_hsa004100.25548937
154Arginine and proline metabolism_Homo sapiens_hsa003300.23905671

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