NBPF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.62492243
2positive regulation of gamma-delta T cell activation (GO:0046645)4.43732184
3modulation by symbiont of host immune response (GO:0052553)3.96687121
4positive regulation by symbiont of host defense response (GO:0052509)3.96687121
5modulation by symbiont of host defense response (GO:0052031)3.96687121
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96687121
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96687121
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.96687121
9macrophage activation involved in immune response (GO:0002281)3.89765536
10cellular extravasation (GO:0045123)3.73380751
11response to peptidoglycan (GO:0032494)3.68266563
12detection of external biotic stimulus (GO:0098581)3.58920317
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58325860
14regulation of gamma-delta T cell activation (GO:0046643)3.58189741
15regulation of B cell receptor signaling pathway (GO:0050855)3.55802293
16detection of other organism (GO:0098543)3.54304629
17microglial cell activation (GO:0001774)3.47479869
18neutrophil activation involved in immune response (GO:0002283)3.31349045
19monoubiquitinated protein deubiquitination (GO:0035520)3.27987747
20cellular response to ethanol (GO:0071361)3.26124825
21detection of biotic stimulus (GO:0009595)3.23813684
22regulation of interferon-beta biosynthetic process (GO:0045357)3.22570996
23neutrophil mediated immunity (GO:0002446)3.21477290
24macrophage activation (GO:0042116)3.20562939
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18716229
26establishment of protein localization to Golgi (GO:0072600)3.14643047
27regulation of gamma-delta T cell differentiation (GO:0045586)3.12668118
28negative regulation of complement activation (GO:0045916)3.11113420
29histone H3-K4 trimethylation (GO:0080182)3.09636411
30response to muramyl dipeptide (GO:0032495)3.08189859
31detection of bacterium (GO:0016045)3.06610877
32pericardium development (GO:0060039)3.04949568
33retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03827156
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.03054526
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02960881
36histone H3-K36 demethylation (GO:0070544)2.97755563
37negative regulation of cell killing (GO:0031342)2.96728342
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96728342
39protein targeting to Golgi (GO:0000042)2.94289748
40negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91203746
41negative regulation of T-helper cell differentiation (GO:0045623)2.91203746
42hepatocyte apoptotic process (GO:0097284)2.90913325
43maintenance of gastrointestinal epithelium (GO:0030277)2.89846868
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81909782
45response to host (GO:0075136)2.81909782
46response to host defenses (GO:0052200)2.81909782
47negative regulation of interleukin-12 production (GO:0032695)2.79641123
48negative regulation of protein activation cascade (GO:2000258)2.78732084
49negative regulation of humoral immune response (GO:0002921)2.77826128
50neutrophil activation (GO:0042119)2.74806197
51regulation of interleukin-12 biosynthetic process (GO:0045075)2.74480563
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74436689
53positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73691389
54response to host immune response (GO:0052572)2.68415081
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68415081
56leukocyte aggregation (GO:0070486)2.67429204
57regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.64000861
58response to laminar fluid shear stress (GO:0034616)2.63635731
59positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62231634
60positive regulation of cellular amide metabolic process (GO:0034250)2.60085704
61definitive hemopoiesis (GO:0060216)2.59711755
62negative regulation of interleukin-8 production (GO:0032717)2.56832931
63growth hormone receptor signaling pathway (GO:0060396)2.54164929
64myeloid leukocyte mediated immunity (GO:0002444)2.53706461
65regulation of MHC class I biosynthetic process (GO:0045343)2.52997357
66antigen processing and presentation of endogenous antigen (GO:0019883)2.52147744
67peptidyl-lysine trimethylation (GO:0018023)2.51694086
68negative regulation of lymphocyte mediated immunity (GO:0002707)2.51623594
69production of molecular mediator involved in inflammatory response (GO:0002532)2.51076792
70B cell receptor signaling pathway (GO:0050853)2.49264714
71myeloid cell activation involved in immune response (GO:0002275)2.46961367
72positive regulation of granulocyte differentiation (GO:0030854)2.46901521
73regulation of T-helper 2 cell differentiation (GO:0045628)2.46735186
74positive regulation of interferon-alpha production (GO:0032727)2.46677554
75dendritic cell migration (GO:0036336)2.45292966
76negative thymic T cell selection (GO:0045060)2.45252893
77granulocyte activation (GO:0036230)2.44507165
78germinal center formation (GO:0002467)2.43243378
79defense response to protozoan (GO:0042832)2.41311325
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.39872202
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.39831423
82regulation of mast cell activation involved in immune response (GO:0033006)2.39601949
83histone H3-K9 modification (GO:0061647)2.39071326
84regulation of mast cell degranulation (GO:0043304)2.38572656
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38359495
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38002252
87regulation of interleukin-8 biosynthetic process (GO:0045414)2.37874692
88regulation of mast cell activation (GO:0033003)2.37077634
89response to type I interferon (GO:0034340)2.36017136
90striated muscle atrophy (GO:0014891)2.34003868
91regulation of macrophage cytokine production (GO:0010935)2.33165592
92negative regulation of T cell mediated immunity (GO:0002710)2.32306474
93negative regulation of immunoglobulin mediated immune response (GO:0002890)2.31681553
94negative regulation of B cell mediated immunity (GO:0002713)2.31681553
95negative T cell selection (GO:0043383)2.31482571
96interleukin-6-mediated signaling pathway (GO:0070102)2.31421838
97cellular response to type I interferon (GO:0071357)2.30890943
98type I interferon signaling pathway (GO:0060337)2.30890943
99positive regulation of interferon-beta production (GO:0032728)2.30053333
100regulation of necroptotic process (GO:0060544)2.29922009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.12914418
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.91289594
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.49199136
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87929800
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84775770
6* ESR1_20079471_ChIP-ChIP_T-47D_Human2.47848390
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29804679
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26180087
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25809272
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23026609
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16997148
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.16099464
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.14505572
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06366196
15VDR_24787735_ChIP-Seq_THP-1_Human2.04221203
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98147575
17RUNX_20019798_ChIP-Seq_JUKART_Human1.95284517
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95271447
19SCL_19346495_ChIP-Seq_HPC-7_Human1.92539724
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91659694
21TP53_16413492_ChIP-PET_HCT116_Human1.86569488
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85646654
23AHR_22903824_ChIP-Seq_MCF-7_Human1.82588251
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81837141
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81093572
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75894030
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.65839282
28GATA1_22025678_ChIP-Seq_K562_Human1.64681277
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63788222
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.63668974
31SPI1_23127762_ChIP-Seq_K562_Human1.62845244
32CJUN_26792858_Chip-Seq_BT549_Human1.59755951
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.59716360
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57324661
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53864511
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53671010
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49430139
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.48460983
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48042737
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.44284649
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44058847
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43870504
43ER_23166858_ChIP-Seq_MCF-7_Human1.42683842
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37137732
45BRD4_25478319_ChIP-Seq_HGPS_Human1.35394882
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31926738
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29113573
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29113573
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28433234
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.26322399
51* MYB_26560356_Chip-Seq_TH2_Human1.25403265
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.24074622
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22053678
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21828168
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.19814670
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19517840
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17689145
58MYB_26560356_Chip-Seq_TH1_Human1.16444309
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15460022
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14925435
61VDR_24763502_ChIP-Seq_THP-1_Human1.14401295
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14365717
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14268216
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14268216
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13601449
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08472259
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07470516
68GBX2_23144817_ChIP-Seq_PC3_Human1.06923064
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.06887757
70* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04301783
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00835719
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00588806
73PU_27001747_Chip-Seq_BMDM_Mouse0.99692402
74TP63_23658742_ChIP-Seq_EP156T_Human0.99601789
75SPI1_23547873_ChIP-Seq_NB4_Human0.99581734
76BCAT_22108803_ChIP-Seq_LS180_Human0.98412326
77AR_21572438_ChIP-Seq_LNCaP_Human0.98398105
78STAT3_23295773_ChIP-Seq_U87_Human0.97984036
79BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97952671
80TCF4_18268006_ChIP-ChIP_LS174T_Human0.97903495
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97177674
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96209883
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96043834
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95253575
85RXR_22108803_ChIP-Seq_LS180_Human0.94493546
86GATA3_27048872_Chip-Seq_THYMUS_Human0.94175132
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93930109
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93841644
89* GATA3_26560356_Chip-Seq_TH2_Human0.92190638
90BP1_19119308_ChIP-ChIP_Hs578T_Human0.91660076
91* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91459592
92RUNX1_27514584_Chip-Seq_MCF-7_Human0.91069937
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91034815
94GATA2_19941826_ChIP-Seq_K562_Human0.90384728
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89080088
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.89009708
97GATA1_19941826_ChIP-Seq_K562_Human0.88734056
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88123791
99SMAD4_21799915_ChIP-Seq_A2780_Human0.86520576
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86472920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.88074214
2MP0003724_increased_susceptibility_to3.01644315
3MP0001835_abnormal_antigen_presentation3.00920043
4MP0003828_pulmonary_edema2.35382710
5MP0008438_abnormal_cutaneous_collagen2.28308850
6MP0003436_decreased_susceptibility_to2.26308041
7MP0003303_peritoneal_inflammation2.25167324
8MP0005275_abnormal_skin_tensile2.22482072
9MP0004883_abnormal_blood_vessel2.19985734
10MP0003300_gastrointestinal_ulcer2.13657628
11MP0008057_abnormal_DNA_replication2.10024219
12MP0006054_spinal_hemorrhage2.05999965
13MP0003091_abnormal_cell_migration2.01330514
14MP0002419_abnormal_innate_immunity2.00539131
15MP0005503_abnormal_tendon_morphology1.86835837
16MP0001800_abnormal_humoral_immune1.86482714
17MP0005164_abnormal_response_to1.85848335
18MP0008260_abnormal_autophagy1.85757354
19MP0003950_abnormal_plasma_membrane1.84315783
20MP0004808_abnormal_hematopoietic_stem1.81689705
21MP0003763_abnormal_thymus_physiology1.81294515
22MP0005076_abnormal_cell_differentiation1.77554423
23MP0003705_abnormal_hypodermis_morpholog1.76374529
24MP0004381_abnormal_hair_follicle1.75228863
25MP0002396_abnormal_hematopoietic_system1.71245183
26MP0001958_emphysema1.67953863
27MP0000685_abnormal_immune_system1.64207384
28MP0003045_fibrosis1.63673553
29MP0002452_abnormal_antigen_presenting1.62471431
30MP0003191_abnormal_cellular_cholesterol1.61715809
31MP0000465_gastrointestinal_hemorrhage1.60331076
32MP0005025_abnormal_response_to1.57481988
33MP0002723_abnormal_immune_serum1.55723750
34MP0002166_altered_tumor_susceptibility1.53128431
35MP0000383_abnormal_hair_follicle1.52678837
36MP0008004_abnormal_stomach_pH1.50729208
37MP0001790_abnormal_immune_system1.50392942
38MP0005387_immune_system_phenotype1.50392942
39MP0004947_skin_inflammation1.50302266
40MP0002009_preneoplasia1.50240281
41MP0009785_altered_susceptibility_to1.48840008
42MP0005000_abnormal_immune_tolerance1.46882853
43MP0005310_abnormal_salivary_gland1.43629169
44MP0001545_abnormal_hematopoietic_system1.42610154
45MP0005397_hematopoietic_system_phenotyp1.42610154
46MP0006082_CNS_inflammation1.42530985
47MP0002405_respiratory_system_inflammati1.38404048
48MP0002168_other_aberrant_phenotype1.38286251
49MP0002420_abnormal_adaptive_immunity1.37926504
50MP0001851_eye_inflammation1.36685953
51MP0001819_abnormal_immune_cell1.36174743
52MP0003252_abnormal_bile_duct1.32695272
53MP0000371_diluted_coat_color1.32301580
54MP0001533_abnormal_skeleton_physiology1.29660048
55MP0002998_abnormal_bone_remodeling1.29192996
56MP0002132_abnormal_respiratory_system1.26016651
57MP0000015_abnormal_ear_pigmentation1.23552277
58MP0005083_abnormal_biliary_tract1.23518908
59MP0005408_hypopigmentation1.22766056
60MP0010678_abnormal_skin_adnexa1.21508268
61MP0005451_abnormal_body_composition1.19786132
62MP0003172_abnormal_lysosome_physiology1.17737723
63MP0005023_abnormal_wound_healing1.16560882
64MP0003279_aneurysm1.15641394
65MP0003656_abnormal_erythrocyte_physiolo1.14813503
66MP0002398_abnormal_bone_marrow1.11816307
67MP0002148_abnormal_hypersensitivity_rea1.11300885
68MP0002928_abnormal_bile_duct1.10223179
69MP0010155_abnormal_intestine_physiology1.09755012
70MP0005171_absent_coat_pigmentation1.08234934
71MP0000716_abnormal_immune_system1.07679133
72MP0009278_abnormal_bone_marrow1.07272599
73MP0005174_abnormal_tail_pigmentation1.06350685
74MP0003183_abnormal_peptide_metabolism1.03156251
75MP0000767_abnormal_smooth_muscle1.00499228
76MP0001845_abnormal_inflammatory_respons0.97903865
77MP0009764_decreased_sensitivity_to0.97855047
78MP0002006_tumorigenesis0.97056185
79MP0002060_abnormal_skin_morphology0.96348751
80MP0000427_abnormal_hair_cycle0.95411918
81MP0002332_abnormal_exercise_endurance0.94678762
82MP0005390_skeleton_phenotype0.94010846
83MP0005464_abnormal_platelet_physiology0.93527277
84MP0001853_heart_inflammation0.93036636
85MP0003566_abnormal_cell_adhesion0.92110193
86MP0005409_darkened_coat_color0.91832350
87MP0003448_altered_tumor_morphology0.91617251
88MP0000689_abnormal_spleen_morphology0.90655224
89MP0000858_altered_metastatic_potential0.90365287
90MP0002722_abnormal_immune_system0.90038890
91MP0002108_abnormal_muscle_morphology0.88522726
92MP0004484_altered_response_of0.88247495
93MP0000249_abnormal_blood_vessel0.87946288
94MP0003866_abnormal_defecation0.86631181
95MP0005248_abnormal_Harderian_gland0.82344046
96MP0003943_abnormal_hepatobiliary_system0.80218542
97MP0002138_abnormal_hepatobiliary_system0.79765451
98MP0002933_joint_inflammation0.77755118
99MP0005388_respiratory_system_phenotype0.76635886
100MP0002133_abnormal_respiratory_system0.76635886

Predicted human phenotypes

RankGene SetZ-score
1Absent frontal sinuses (HP:0002688)4.41809795
2Spondylolisthesis (HP:0003302)3.65450185
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.53404188
4Recurrent bacterial skin infections (HP:0005406)3.47496131
5Recurrent abscess formation (HP:0002722)3.32452145
6Peritonitis (HP:0002586)3.23975596
7Retrobulbar optic neuritis (HP:0100654)3.18723539
8Optic neuritis (HP:0100653)3.18723539
9Orchitis (HP:0100796)3.09680430
10Eczematoid dermatitis (HP:0000976)3.06211575
11Narrow palate (HP:0000189)3.00504836
12Myositis (HP:0100614)2.98469450
13Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.89840240
14Abnormality of the fingertips (HP:0001211)2.82653046
15Abnormality of the frontal sinuses (HP:0002687)2.80341853
16Spinal cord lesions (HP:0100561)2.75636534
17Syringomyelia (HP:0003396)2.75636534
18Recurrent gram-negative bacterial infections (HP:0005420)2.73565939
19Aortic aneurysm (HP:0004942)2.72972135
20Abnormality of incisor morphology (HP:0011063)2.67333937
21Aortic dissection (HP:0002647)2.65052061
22Abnormality of macrophages (HP:0004311)2.59412900
23Recurrent fungal infections (HP:0002841)2.55684844
24Subacute progressive viral hepatitis (HP:0006572)2.54711638
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50171299
26Osteolytic defects of the hand bones (HP:0009699)2.46726120
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.46726120
28Gingival bleeding (HP:0000225)2.40601555
29Hypoplastic ischia (HP:0003175)2.38964515
30Chronic mucocutaneous candidiasis (HP:0002728)2.38192331
31Recurrent cutaneous fungal infections (HP:0011370)2.38192331
32Mitral stenosis (HP:0001718)2.37706720
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.36306477
34Gingivitis (HP:0000230)2.30012136
35Gastrointestinal infarctions (HP:0005244)2.29985525
36Long eyelashes (HP:0000527)2.29616393
37Recurrent skin infections (HP:0001581)2.29026839
38Periodontitis (HP:0000704)2.28024599
39Keratoconjunctivitis sicca (HP:0001097)2.27074423
40Prolonged bleeding time (HP:0003010)2.26233971
41Elevated erythrocyte sedimentation rate (HP:0003565)2.20151382
42Abnormality of the nasal septum (HP:0000419)2.19650229
43Abnormality of the ischium (HP:0003174)2.19077430
44Cerebral aneurysm (HP:0004944)2.18093301
45Prominent nose (HP:0000448)2.17338892
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16398555
47Dislocated radial head (HP:0003083)2.15223457
48Abnormality of T cell number (HP:0011839)2.14928808
49Arterial tortuosity (HP:0005116)2.14506910
50T lymphocytopenia (HP:0005403)2.10061841
51Abnormality of the epiphyses of the hand (HP:0005924)2.04765091
52Hypoplasia of the iris (HP:0007676)2.03195504
53Keratoconjunctivitis (HP:0001096)2.02007108
54Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.01489008
55Stomach cancer (HP:0012126)1.99717867
56Mitral valve prolapse (HP:0001634)1.98022324
57Recurrent viral infections (HP:0004429)1.96768076
58Abnormality of the radial head (HP:0003995)1.95363481
59Viral hepatitis (HP:0006562)1.94331786
60Tibial bowing (HP:0002982)1.93882478
61Spontaneous hematomas (HP:0007420)1.91721300
62Hemoptysis (HP:0002105)1.91170801
63Epistaxis (HP:0000421)1.91162175
64Abnormality of the sella turcica (HP:0002679)1.89504985
65Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.88717842
66Leukocytosis (HP:0001974)1.88259680
67Pulmonary artery stenosis (HP:0004415)1.88007724
68Colitis (HP:0002583)1.87598420
69Vascular tortuosity (HP:0004948)1.87000710
70Pulmonary infiltrates (HP:0002113)1.86953484
71Stomatitis (HP:0010280)1.86430118
72Hypoplastic iliac wings (HP:0002866)1.84459307
73Dilatation of the ascending aorta (HP:0005111)1.84107579
74Arterial thrombosis (HP:0004420)1.83666069
75Vasculitis (HP:0002633)1.82953420
76Acute myeloid leukemia (HP:0004808)1.81385135
77Sparse lateral eyebrow (HP:0005338)1.80843288
78Mediastinal lymphadenopathy (HP:0100721)1.80794824
79Large earlobe (HP:0009748)1.80089866
80Coarse hair (HP:0002208)1.79287238
81Inflammation of the large intestine (HP:0002037)1.77541189
82Abnormality of the peritoneum (HP:0002585)1.76968347
83Eosinophilia (HP:0001880)1.75902576
84Lip pit (HP:0100267)1.75685419
85Low anterior hairline (HP:0000294)1.75302622
86Widely spaced teeth (HP:0000687)1.74975594
87Long clavicles (HP:0000890)1.74024461
88Follicular hyperkeratosis (HP:0007502)1.71532726
89Genetic anticipation (HP:0003743)1.71171384
90Mild short stature (HP:0003502)1.70600108
91Neonatal short-limb short stature (HP:0008921)1.70114525
92Micronodular cirrhosis (HP:0001413)1.70019919
93Myocardial infarction (HP:0001658)1.67818009
94Broad face (HP:0000283)1.67510899
95Granulocytopenia (HP:0001913)1.67270538
96Increased number of teeth (HP:0011069)1.67082280
97Aneurysm (HP:0002617)1.66834170
98Delayed closure of the anterior fontanelle (HP:0001476)1.65969423
99Pustule (HP:0200039)1.65891165
100Chest pain (HP:0100749)1.64924323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.11775486
2CDK122.90862314
3FRK2.78727944
4TYK22.55372990
5RIPK42.28972600
6MAP2K32.06069266
7MAP3K32.03207331
8BMPR22.03012842
9PIK3CG1.90993624
10MST1R1.87981332
11TAOK31.84399944
12JAK11.82920528
13AKT31.77488478
14CSK1.59189992
15IKBKE1.52026912
16MAP3K141.48970955
17BRD41.48612002
18JAK31.45395803
19WNK11.43192906
20IRAK41.42653446
21ZAP701.41773819
22SGK21.34508337
23TRPM71.34426242
24PRPF4B1.30990973
25CAMK1G1.30555553
26MARK31.29121558
27MAP3K61.28749577
28FGFR31.28635676
29NLK1.27374258
30MARK21.25410802
31MAP3K71.24018446
32PDGFRB1.22880506
33HCK1.21105258
34IRAK11.20455820
35CAMK1D1.18920305
36MAP3K131.17992183
37MAP3K21.17326399
38TGFBR21.14193022
39EPHB11.13681121
40PTK2B1.12495431
41MELK1.12093280
42SGK31.11720687
43FGR1.11097270
44TNK21.10872987
45LATS11.10860630
46YES11.08909622
47STK381.07628931
48FES1.04440200
49BTK1.03690356
50NEK61.03500399
51ACVR1B1.03145489
52GRK61.02153180
53IKBKB1.00363332
54CHUK0.99434480
55MAPK70.98001807
56CSF1R0.97703510
57CDC42BPA0.96801494
58KIT0.96204733
59JAK20.95691582
60SIK30.94898736
61PRKD20.92737510
62SYK0.91658740
63ERN10.91469151
64MAP4K10.90080507
65TEC0.88663519
66EPHA30.86704914
67ERBB20.86660243
68TAOK10.85093374
69MAP3K10.81984313
70TXK0.81406218
71DDR20.73562618
72MTOR0.72769845
73SIK10.71850526
74LCK0.71152047
75NEK90.70687139
76STK100.68966829
77TRIB30.64408935
78LYN0.63892983
79TBK10.63301629
80MUSK0.60882145
81MET0.59697046
82PRKAA20.58535927
83FGFR20.57272142
84FER0.57112909
85BMPR1B0.56816379
86FGFR40.55109518
87KSR10.54766294
88HIPK20.54390681
89PIK3CA0.53448822
90BRSK20.52747119
91CDK60.52255258
92STK38L0.49983271
93RET0.47523292
94IRAK20.46898791
95ABL10.46359041
96RAF10.45903976
97PKN20.45247577
98RIPK10.45069581
99SGK10.44570764
100SGK2230.44165895

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.27119906
2Osteoclast differentiation_Homo sapiens_hsa043802.21872005
3Staphylococcus aureus infection_Homo sapiens_hsa051502.08979133
4Dorso-ventral axis formation_Homo sapiens_hsa043201.85867385
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72668853
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70456322
7B cell receptor signaling pathway_Homo sapiens_hsa046621.65539381
8Malaria_Homo sapiens_hsa051441.60705145
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.57659369
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56215360
11Tuberculosis_Homo sapiens_hsa051521.54600964
12Influenza A_Homo sapiens_hsa051641.51181568
13TNF signaling pathway_Homo sapiens_hsa046681.47697230
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.47250764
15Toxoplasmosis_Homo sapiens_hsa051451.46663120
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45025304
17Measles_Homo sapiens_hsa051621.42179416
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40856633
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39581148
20Acute myeloid leukemia_Homo sapiens_hsa052211.37853408
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35868855
22Platelet activation_Homo sapiens_hsa046111.35134072
23Legionellosis_Homo sapiens_hsa051341.33608824
24Non-small cell lung cancer_Homo sapiens_hsa052231.29873908
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28871035
26Graft-versus-host disease_Homo sapiens_hsa053321.27944313
27Hepatitis B_Homo sapiens_hsa051611.26236666
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26125028
29Chronic myeloid leukemia_Homo sapiens_hsa052201.25358501
30Other glycan degradation_Homo sapiens_hsa005111.24267530
31FoxO signaling pathway_Homo sapiens_hsa040681.19142653
32Amoebiasis_Homo sapiens_hsa051461.18733198
33T cell receptor signaling pathway_Homo sapiens_hsa046601.17330805
34Complement and coagulation cascades_Homo sapiens_hsa046101.12586720
35Pancreatic cancer_Homo sapiens_hsa052121.11291339
36Allograft rejection_Homo sapiens_hsa053301.10354871
37Renal cell carcinoma_Homo sapiens_hsa052111.08210885
38Prostate cancer_Homo sapiens_hsa052151.07243828
39Herpes simplex infection_Homo sapiens_hsa051681.05245138
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04420810
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04343562
42Hematopoietic cell lineage_Homo sapiens_hsa046401.04333720
43Prolactin signaling pathway_Homo sapiens_hsa049171.01463646
44Chemokine signaling pathway_Homo sapiens_hsa040621.00655102
45African trypanosomiasis_Homo sapiens_hsa051431.00266963
46Hepatitis C_Homo sapiens_hsa051600.99149474
47Choline metabolism in cancer_Homo sapiens_hsa052310.98575115
48Autoimmune thyroid disease_Homo sapiens_hsa053200.98419251
49Pertussis_Homo sapiens_hsa051330.98251365
50Notch signaling pathway_Homo sapiens_hsa043300.97754246
51ABC transporters_Homo sapiens_hsa020100.96992416
52Endometrial cancer_Homo sapiens_hsa052130.93553719
53Lysine degradation_Homo sapiens_hsa003100.93543350
54Inositol phosphate metabolism_Homo sapiens_hsa005620.91368843
55Focal adhesion_Homo sapiens_hsa045100.91267624
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.91173300
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90080011
58MicroRNAs in cancer_Homo sapiens_hsa052060.89591734
59Small cell lung cancer_Homo sapiens_hsa052220.89446341
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.87014663
61Proteoglycans in cancer_Homo sapiens_hsa052050.84967239
62mTOR signaling pathway_Homo sapiens_hsa041500.83797002
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83775381
64ErbB signaling pathway_Homo sapiens_hsa040120.81658802
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.78204328
66Apoptosis_Homo sapiens_hsa042100.77231220
67ECM-receptor interaction_Homo sapiens_hsa045120.76642821
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.76260994
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.75770666
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75755581
71Asthma_Homo sapiens_hsa053100.73593551
72Insulin resistance_Homo sapiens_hsa049310.73459638
73Adherens junction_Homo sapiens_hsa045200.73141782
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72002727
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71179443
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70786761
77GnRH signaling pathway_Homo sapiens_hsa049120.68917484
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66608508
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65675862
80HIF-1 signaling pathway_Homo sapiens_hsa040660.63849838
81Glioma_Homo sapiens_hsa052140.63351797
82Circadian rhythm_Homo sapiens_hsa047100.63328467
83Viral myocarditis_Homo sapiens_hsa054160.63252672
84Antigen processing and presentation_Homo sapiens_hsa046120.61818265
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61674766
86Colorectal cancer_Homo sapiens_hsa052100.61125156
87VEGF signaling pathway_Homo sapiens_hsa043700.59825644
88Phagosome_Homo sapiens_hsa041450.58253122
89Estrogen signaling pathway_Homo sapiens_hsa049150.57269445
90HTLV-I infection_Homo sapiens_hsa051660.55929218
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.54625142
92TGF-beta signaling pathway_Homo sapiens_hsa043500.54549590
93MAPK signaling pathway_Homo sapiens_hsa040100.54232001
94Pathways in cancer_Homo sapiens_hsa052000.53470971
95Type II diabetes mellitus_Homo sapiens_hsa049300.53237903
96Primary immunodeficiency_Homo sapiens_hsa053400.52776289
97Lysosome_Homo sapiens_hsa041420.52240752
98Viral carcinogenesis_Homo sapiens_hsa052030.49706242
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.49079070
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48097924

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