ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	9.28204809
2	drug catabolic process (GO:0042737)	8.61849841
3	exogenous drug catabolic process (GO:0042738)	8.43493724
4	epoxygenase P450 pathway (GO:0019373)	8.08291115
5	regulation of fibrinolysis (GO:0051917)	7.63808951
6	negative regulation of fibrinolysis (GO:0051918)	7.38140299
7	omega-hydroxylase P450 pathway (GO:0097267)	7.33243912
8	L-phenylalanine catabolic process (GO:0006559)	7.29458868
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.29458868
10	regulation of protein activation cascade (GO:2000257)	6.93756866
11	complement activation, alternative pathway (GO:0006957)	6.67219555
12	L-phenylalanine metabolic process (GO:0006558)	6.57973153
13	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.57973153
14	cellular glucuronidation (GO:0052695)	6.57076260
15	urea metabolic process (GO:0019627)	6.37717989
16	serine family amino acid catabolic process (GO:0009071)	6.31132527
17	regulation of complement activation (GO:0030449)	6.30496690
18	drug metabolic process (GO:0017144)	6.25043483
19	glucuronate metabolic process (GO:0019585)	6.24279925
20	uronic acid metabolic process (GO:0006063)	6.24279925
21	peptidyl-glutamic acid carboxylation (GO:0017187)	6.11445519
22	protein carboxylation (GO:0018214)	6.11445519
23	bile acid biosynthetic process (GO:0006699)	6.09508500
24	oxidative demethylation (GO:0070989)	6.05942336
25	nitrogen cycle metabolic process (GO:0071941)	6.01285420
26	fibrinolysis (GO:0042730)	6.00749189
27	blood coagulation, intrinsic pathway (GO:0007597)	5.95706060
28	phenylpropanoid metabolic process (GO:0009698)	5.92991519
29	regulation of triglyceride catabolic process (GO:0010896)	5.79190484
30	glycine metabolic process (GO:0006544)	5.75960139
31	ethanol oxidation (GO:0006069)	5.70963138
32	urea cycle (GO:0000050)	5.49160968
33	bile acid metabolic process (GO:0008206)	5.43597743
34	aromatic amino acid family catabolic process (GO:0009074)	5.43242679
35	negative regulation of sterol transport (GO:0032372)	5.12703237
36	negative regulation of cholesterol transport (GO:0032375)	5.12703237
37	S-adenosylmethionine metabolic process (GO:0046500)	5.09169453
38	bile acid and bile salt transport (GO:0015721)	5.00906976
39	hormone catabolic process (GO:0042447)	4.87901491
40	amino-acid betaine metabolic process (GO:0006577)	4.72469948
41	triglyceride homeostasis (GO:0070328)	4.68085178
42	acylglycerol homeostasis (GO:0055090)	4.68085178
43	serine family amino acid metabolic process (GO:0009069)	4.66739857
44	ethanol metabolic process (GO:0006067)	4.61030557
45	negative regulation of blood coagulation (GO:0030195)	4.59611221
46	negative regulation of hemostasis (GO:1900047)	4.59611221
47	alkaloid metabolic process (GO:0009820)	4.51301804
48	protein activation cascade (GO:0072376)	4.45314211
49	negative regulation of protein activation cascade (GO:2000258)	4.31912683
50	regulation of plasminogen activation (GO:0010755)	4.27385087
51	regulation of humoral immune response (GO:0002920)	4.20696651
52	steroid catabolic process (GO:0006706)	4.18926681
53	negative regulation of coagulation (GO:0050819)	4.15327671
54	tyrosine metabolic process (GO:0006570)	4.13056612
55	negative regulation of wound healing (GO:0061045)	4.13003545
56	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.12303315
57	arginine metabolic process (GO:0006525)	4.10873789
58	phospholipid efflux (GO:0033700)	4.07728700
59	complement activation (GO:0006956)	4.07669788
60	acute-phase response (GO:0006953)	4.01473535
61	positive regulation of triglyceride lipase activity (GO:0061365)	3.97259364
62	positive regulation of lipoprotein lipase activity (GO:0051006)	3.97259364
63	negative regulation of complement activation (GO:0045916)	3.96238892
64	cytolysis (GO:0019835)	3.91309548
65	complement activation, classical pathway (GO:0006958)	3.89145382
66	flavonoid metabolic process (GO:0009812)	3.88196674
67	cellular ketone body metabolic process (GO:0046950)	3.86141849
68	alpha-amino acid catabolic process (GO:1901606)	3.85442595
69	fat-soluble vitamin biosynthetic process (GO:0042362)	3.79934236
70	serine family amino acid biosynthetic process (GO:0009070)	3.79902290
71	regulation of lipoprotein particle clearance (GO:0010984)	3.78755914
72	tryptophan catabolic process (GO:0006569)	3.77717177
73	indole-containing compound catabolic process (GO:0042436)	3.77717177
74	indolalkylamine catabolic process (GO:0046218)	3.77717177
75	xenobiotic metabolic process (GO:0006805)	3.76111641
76	cholesterol efflux (GO:0033344)	3.73112774
77	protein-lipid complex remodeling (GO:0034368)	3.71604616
78	macromolecular complex remodeling (GO:0034367)	3.71604616
79	plasma lipoprotein particle remodeling (GO:0034369)	3.71604616
80	heme transport (GO:0015886)	3.68586344
81	positive regulation of blood coagulation (GO:0030194)	3.68239145
82	positive regulation of hemostasis (GO:1900048)	3.68239145
83	cysteine metabolic process (GO:0006534)	3.68191675
84	aromatic amino acid family metabolic process (GO:0009072)	3.64657548
85	drug transmembrane transport (GO:0006855)	3.60827035
86	very-low-density lipoprotein particle assembly (GO:0034379)	3.60482844
87	imidazole-containing compound metabolic process (GO:0052803)	3.60018499
88	xenobiotic catabolic process (GO:0042178)	3.59647446
89	regulation of cholesterol esterification (GO:0010872)	3.54373852
90	high-density lipoprotein particle remodeling (GO:0034375)	3.52731240
91	intestinal cholesterol absorption (GO:0030299)	3.49444914
92	negative regulation of lipase activity (GO:0060192)	3.46513618
93	cofactor catabolic process (GO:0051187)	3.46420109
94	ketone body metabolic process (GO:1902224)	3.44301359
95	positive regulation of coagulation (GO:0050820)	3.41719795
96	drug transport (GO:0015893)	3.41050514
97	negative regulation of humoral immune response (GO:0002921)	3.40697078
98	glutamate metabolic process (GO:0006536)	3.39415595
99	cellular amino acid catabolic process (GO:0009063)	3.38849738
100	sodium-independent organic anion transport (GO:0043252)	3.33865144

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.27802634
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.90790516
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	6.17878653
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.20380343
5	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.80949204
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.55964156
7	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.00406706
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.79759322
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.27233582
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.97638483
11	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.93052251
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54437314
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.37508053
14	HTT_18923047_ChIP-ChIP_STHdh_Human	2.25203341
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24086230
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.93831221
17	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.74211511
18	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.55590038
19	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.50478740
20	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.46192706
21	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.45848411
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.39163344
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.35820699
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.35748060
25	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.31429766
26	GATA1_22025678_ChIP-Seq_K562_Human	1.31216537
27	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.21920177
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.21120484
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20985571
30	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.20305744
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20036910
32	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.18661374
33	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.18496332
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.18401574
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.18078563
36	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.14562297
37	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12329554
38	PHF8_20622853_ChIP-Seq_HELA_Human	1.11286920
39	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10385964
40	AR_20517297_ChIP-Seq_VCAP_Human	1.09835110
41	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06489756
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05895476
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05421125
44	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.00883111
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99771296
46	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99324504
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97037290
48	RUNX_20019798_ChIP-Seq_JUKART_Human	0.95866303
49	ERG_20517297_ChIP-Seq_VCAP_Human	0.95327933
50	GATA3_26560356_Chip-Seq_TH2_Human	0.94195227
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93105464
52	NFYA_21822215_ChIP-Seq_K562_Human	0.92837242
53	CEBPB_22108803_ChIP-Seq_LS180_Human	0.92595823
54	RAC3_21632823_ChIP-Seq_H3396_Human	0.92366232
55	ERA_21632823_ChIP-Seq_H3396_Human	0.90139368
56	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.89892850
57	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.87780351
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86642264
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.86113711
60	NANOG_19829295_ChIP-Seq_ESCs_Human	0.85840646
61	SOX2_19829295_ChIP-Seq_ESCs_Human	0.85840646
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.85797540
63	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.84749501
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.84522501
65	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.84067724
66	MYC_19829295_ChIP-Seq_ESCs_Human	0.83403089
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.83108433
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.82397941
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.82397941
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.81879109
71	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.81647383
72	ETV1_20927104_ChIP-Seq_GIST48_Human	0.80547167
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.80400678
74	RBPJ_21746931_ChIP-Seq_IB4_Human	0.80386312
75	NANOG_20526341_ChIP-Seq_ESCs_Human	0.80110566
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.79748803
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.77481088
78	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.76954923
79	NCOR_22424771_ChIP-Seq_293T_Human	0.76877909
80	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.76809727
81	SOX2_21211035_ChIP-Seq_LN229_Human	0.75923218
82	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.75887826
83	SPI1_20517297_ChIP-Seq_HL60_Human	0.75377394
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.74751632
85	NFYB_21822215_ChIP-Seq_K562_Human	0.74419663
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.74414749
87	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.74387991
88	GATA3_26560356_Chip-Seq_TH1_Human	0.74374794
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.74074116
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.73226475
91	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.73136358
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.72573735
93	CBP_20019798_ChIP-Seq_JUKART_Human	0.72414171
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.72414171
95	GATA4_25053715_ChIP-Seq_YYC3_Human	0.72265017
96	P300_27268052_Chip-Seq_Bcells_Human	0.71880851
97	CBP_21632823_ChIP-Seq_H3396_Human	0.68993020
98	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.68667190
99	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.67917239
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.67640266

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.86396874
2	MP0005360_urolithiasis	6.07286399
3	MP0005085_abnormal_gallbladder_physiolo	5.96834436
4	MP0002138_abnormal_hepatobiliary_system	5.35274952
5	MP0005365_abnormal_bile_salt	5.11900821
6	MP0008875_abnormal_xenobiotic_pharmacok	4.90990876
7	MP0003195_calcinosis	4.74162752
8	MP0003868_abnormal_feces_composition	3.98894730
9	MP0003252_abnormal_bile_duct	3.89451717
10	MP0009697_abnormal_copulation	3.89383659
11	MP0002876_abnormal_thyroid_physiology	3.33204847
12	MP0001666_abnormal_nutrient_absorption	3.09076099
13	MP0003806_abnormal_nucleotide_metabolis	2.47565154
14	MP0010329_abnormal_lipoprotein_level	2.44039815
15	MP0005332_abnormal_amino_acid	2.24937726
16	MP0001764_abnormal_homeostasis	1.95954842
17	MP0000609_abnormal_liver_physiology	1.72163480
18	MP0002118_abnormal_lipid_homeostasis	1.56250956
19	MP0009840_abnormal_foam_cell	1.53552273
20	MP0003191_abnormal_cellular_cholesterol	1.47515460
21	MP0003656_abnormal_erythrocyte_physiolo	1.34329375
22	MP0005408_hypopigmentation	1.28010778
23	MP0001661_extended_life_span	1.26643779
24	MP0004019_abnormal_vitamin_homeostasis	1.26131233
25	MP0005319_abnormal_enzyme/_coenzyme	1.14107916
26	MP0010368_abnormal_lymphatic_system	1.12921993
27	MP0002132_abnormal_respiratory_system	1.11082903
28	MP0005464_abnormal_platelet_physiology	1.09734069
29	MP0009643_abnormal_urine_homeostasis	1.09306149
30	MP0009785_altered_susceptibility_to	1.02553909
31	MP0000598_abnormal_liver_morphology	1.02311063
32	MP0008469_abnormal_protein_level	0.96420314
33	MP0005584_abnormal_enzyme/coenzyme_acti	0.95667931
34	MP0005376_homeostasis/metabolism_phenot	0.88113343
35	MP0009642_abnormal_blood_homeostasis	0.87392864
36	MP0009763_increased_sensitivity_to	0.85813824
37	MP0003638_abnormal_response/metabolism_	0.83031490
38	MP0009764_decreased_sensitivity_to	0.79678312
39	MP0002168_other_aberrant_phenotype	0.79413932
40	MP0005636_abnormal_mineral_homeostasis	0.79152664
41	MP0008872_abnormal_physiological_respon	0.77808242
42	MP0003186_abnormal_redox_activity	0.77337739
43	MP0000604_amyloidosis	0.76730308
44	MP0002254_reproductive_system_inflammat	0.76080550
45	MP0005395_other_phenotype	0.75968130
46	MP0005187_abnormal_penis_morphology	0.75577201
47	MP0005535_abnormal_body_temperature	0.69295612
48	MP0005671_abnormal_response_to	0.67973772
49	MP0009333_abnormal_splenocyte_physiolog	0.65727311
50	MP0005410_abnormal_fertilization	0.64268618
51	MP0005266_abnormal_metabolism	0.62554471
52	MP0000249_abnormal_blood_vessel	0.58113147
53	MP0000685_abnormal_immune_system	0.57862498
54	MP0006082_CNS_inflammation	0.56611456
55	MP0005058_abnormal_lysosome_morphology	0.56005988
56	MP0005025_abnormal_response_to	0.55945521
57	MP0005075_abnormal_melanosome_morpholog	0.55091937
58	MP0001915_intracranial_hemorrhage	0.53616646
59	MP0001845_abnormal_inflammatory_respons	0.53063619
60	MP0004043_abnormal_pH_regulation	0.52907118
61	MP0002078_abnormal_glucose_homeostasis	0.52355456
62	MP0008874_decreased_physiological_sensi	0.51760176
63	MP0010386_abnormal_urinary_bladder	0.50142922
64	MP0003436_decreased_susceptibility_to	0.49806206
65	MP0001835_abnormal_antigen_presentation	0.49656921
66	MP0005670_abnormal_white_adipose	0.49107666
67	MP0005084_abnormal_gallbladder_morpholo	0.48432837
68	MP0001800_abnormal_humoral_immune	0.48430696
69	MP0003879_abnormal_hair_cell	0.47464456
70	MP0002928_abnormal_bile_duct	0.46689915
71	MP0002971_abnormal_brown_adipose	0.46407907
72	MP0005166_decreased_susceptibility_to	0.46109698
73	MP0004885_abnormal_endolymph	0.45727496
74	MP0002419_abnormal_innate_immunity	0.45499123
75	MP0006036_abnormal_mitochondrial_physio	0.45154003
76	MP0003763_abnormal_thymus_physiology	0.44675344
77	MP0009765_abnormal_xenobiotic_induced	0.43486787
78	MP0000372_irregular_coat_pigmentation	0.43418677
79	MP0005000_abnormal_immune_tolerance	0.42935924
80	MP0003690_abnormal_glial_cell	0.42651208
81	MP0002136_abnormal_kidney_physiology	0.42585523
82	MP0000689_abnormal_spleen_morphology	0.42104747
83	MP0003011_delayed_dark_adaptation	0.42035826
84	MP0003045_fibrosis	0.40688976
85	MP0005334_abnormal_fat_pad	0.39477522
86	MP0001851_eye_inflammation	0.37829705
87	MP0005377_hearing/vestibular/ear_phenot	0.37646430
88	MP0003878_abnormal_ear_physiology	0.37646430
89	MP0008873_increased_physiological_sensi	0.36267944
90	MP0010155_abnormal_intestine_physiology	0.36176527
91	MP0002723_abnormal_immune_serum	0.35950523
92	MP0004130_abnormal_muscle_cell	0.35251944
93	MP0003075_altered_response_to	0.35031350
94	MP0003959_abnormal_lean_body	0.34477766
95	MP0002405_respiratory_system_inflammati	0.34451293
96	MP0001790_abnormal_immune_system	0.33034771
97	MP0005387_immune_system_phenotype	0.33034771
98	MP0003953_abnormal_hormone_level	0.32317105
99	MP0005645_abnormal_hypothalamus_physiol	0.31367170
100	MP0002148_abnormal_hypersensitivity_rea	0.30825881

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	9.93396825
2	Prolonged partial thromboplastin time (HP:0003645)	8.83843113
3	Complement deficiency (HP:0004431)	7.29591965
4	Hypobetalipoproteinemia (HP:0003563)	7.24858135
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.03052156
6	Conjugated hyperbilirubinemia (HP:0002908)	6.02265269
7	Abnormality of complement system (HP:0005339)	5.74581873
8	Joint hemorrhage (HP:0005261)	5.64465818
9	Hyperlipoproteinemia (HP:0010980)	5.44355990
10	Intrahepatic cholestasis (HP:0001406)	5.36838238
11	Abnormality of pyrimidine metabolism (HP:0004353)	5.18347827
12	Systemic lupus erythematosus (HP:0002725)	4.90449164
13	Abnormality of the common coagulation pathway (HP:0010990)	4.34144975
14	Glomerulonephritis (HP:0000099)	4.28212116
15	Recurrent gram-negative bacterial infections (HP:0005420)	4.02631066
16	Delayed CNS myelination (HP:0002188)	3.93483117
17	Hypolipoproteinemia (HP:0010981)	3.92651247
18	Reduced antithrombin III activity (HP:0001976)	3.87463371
19	Xanthomatosis (HP:0000991)	3.86981538
20	Generalized aminoaciduria (HP:0002909)	3.76804849
21	Hyperammonemia (HP:0001987)	3.55401402
22	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.55229180
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.46720589
24	Hyperglycinemia (HP:0002154)	3.34344866
25	Abnormality of the intrinsic pathway (HP:0010989)	3.33921510
26	Spontaneous abortion (HP:0005268)	3.14931827
27	Fat malabsorption (HP:0002630)	3.03602233
28	Abnormality of methionine metabolism (HP:0010901)	3.02304091
29	Pulmonary embolism (HP:0002204)	2.91326488
30	Nephritis (HP:0000123)	2.87135602
31	Abnormality of serine family amino acid metabolism (HP:0010894)	2.80691607
32	Abnormality of glycine metabolism (HP:0010895)	2.80691607
33	Rickets (HP:0002748)	2.79137365
34	Hyperbilirubinemia (HP:0002904)	2.76529807
35	Osteomalacia (HP:0002749)	2.72340692
36	Abnormal biliary tract physiology (HP:0012439)	2.68580967
37	Bile duct proliferation (HP:0001408)	2.68580967
38	Abnormality of nucleobase metabolism (HP:0010932)	2.60852693
39	Steatorrhea (HP:0002570)	2.57268006
40	Gingival bleeding (HP:0000225)	2.54695835
41	Metabolic acidosis (HP:0001942)	2.54345389
42	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.54119973
43	Hypoalphalipoproteinemia (HP:0003233)	2.52771052
44	Abnormality of serum amino acid levels (HP:0003112)	2.49890010
45	Hyperglycinuria (HP:0003108)	2.49760169
46	Abnormality of urine glucose concentration (HP:0011016)	2.49584379
47	Glycosuria (HP:0003076)	2.49584379
48	Menorrhagia (HP:0000132)	2.45929075
49	Hyperphosphaturia (HP:0003109)	2.44931722
50	Arthropathy (HP:0003040)	2.40839998
51	Neonatal hypoglycemia (HP:0001998)	2.37738982
52	Ketosis (HP:0001946)	2.37539861
53	Fair hair (HP:0002286)	2.33807272
54	Thrombophlebitis (HP:0004418)	2.27429757
55	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.26766870
56	Abnormality of vitamin metabolism (HP:0100508)	2.25721306
57	Joint swelling (HP:0001386)	2.23820252
58	Elevated alkaline phosphatase (HP:0003155)	2.22981854
59	Purpura (HP:0000979)	2.22648295
60	Gangrene (HP:0100758)	2.22261557
61	Cholelithiasis (HP:0001081)	2.19408765
62	Abnormal gallbladder physiology (HP:0012438)	2.14268065
63	Cholecystitis (HP:0001082)	2.14268065
64	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.13918205
65	Abnormal gallbladder morphology (HP:0012437)	2.10852188
66	Abnormal enzyme/coenzyme activity (HP:0012379)	2.08254796
67	Vascular calcification (HP:0004934)	2.06371166
68	Hypochromic microcytic anemia (HP:0004840)	2.01935570
69	Hypochromic anemia (HP:0001931)	2.00776405
70	Deep venous thrombosis (HP:0002625)	10.1012316
71	Abnormality of alkaline phosphatase activity (HP:0004379)	1.99077511
72	Epidermoid cyst (HP:0200040)	1.96161078
73	Abnormal urine phosphate concentration (HP:0012599)	1.94963625
74	Cerebral palsy (HP:0100021)	1.93541826
75	Abnormality of fatty-acid metabolism (HP:0004359)	1.91812349
76	Hemorrhage of the eye (HP:0011885)	1.91759610
77	Gastrointestinal infarctions (HP:0005244)	1.89985712
78	Poikilocytosis (HP:0004447)	1.89964821
79	Hypercholesterolemia (HP:0003124)	1.89894115
80	Pancreatitis (HP:0001733)	1.88755748
81	Epistaxis (HP:0000421)	1.86684475
82	Hypophosphatemia (HP:0002148)	1.86335961
83	Alkalosis (HP:0001948)	1.84175102
84	Lethargy (HP:0001254)	1.82720339
85	Renal cortical cysts (HP:0000803)	1.82624932
86	Irritability (HP:0000737)	1.82382648
87	Hepatocellular carcinoma (HP:0001402)	1.80712732
88	Mitral stenosis (HP:0001718)	1.79269798
89	Abnormality of iron homeostasis (HP:0011031)	1.77437262
90	Sensorimotor neuropathy (HP:0007141)	1.76206981
91	Submucous cleft hard palate (HP:0000176)	1.75263934
92	Cardiovascular calcification (HP:0011915)	1.71960424
93	Increased serum ferritin (HP:0003281)	1.71591214
94	Abnormality of the gallbladder (HP:0005264)	1.66428238
95	Abnormality of transition element cation homeostasis (HP:0011030)	1.65367264
96	Azoospermia (HP:0000027)	1.64636544
97	Anorexia (HP:0002039)	1.62177049
98	Generalized hypopigmentation of hair (HP:0011358)	1.61246361
99	Hypophosphatemic rickets (HP:0004912)	1.59689528
100	Cerebral edema (HP:0002181)	1.59490784

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.01715148
2	MUSK	3.73125075
3	PINK1	3.29797551
4	AKT3	3.25665671
5	MAP4K1	3.16828689
6	TXK	3.13992313
7	PIK3CG	3.00585876
8	GRK6	2.93808684
9	ERN1	2.22427932
10	FES	2.10608253
11	TNK2	1.94799146
12	BCKDK	1.88994572
13	PIK3CA	1.71710165
14	LATS1	1.67899258
15	FRK	1.64753097
16	NUAK1	1.64088330
17	PRKCQ	1.61548804
18	TYK2	1.61176747
19	ZAP70	1.49625455
20	INSRR	1.40796077
21	KDR	1.38454857
22	IKBKE	1.36282175
23	TBK1	1.36165673
24	TESK2	1.35025798
25	SYK	1.25501695
26	CSF1R	1.24414359
27	JAK1	1.20453344
28	DAPK2	1.20163384
29	ITK	1.19724598
30	MAP2K2	1.18066089
31	KIT	1.13282627
32	MAP3K11	1.13184664
33	MAPK12	1.10542985
34	BTK	1.10497106
35	MAPK11	1.07954103
36	IKBKB	1.07065609
37	MAP2K4	1.06662625
38	MAP4K2	1.05102609
39	PLK4	1.04845099
40	PRKACG	0.97398464
41	CDK3	0.97061846
42	TEC	0.94924794
43	ADRBK2	0.90394615
44	BCR	0.89574102
45	MAP3K3	0.88156794
46	CAMKK2	0.87875628
47	LCK	0.87788460
48	MAP3K6	0.87434294
49	RIPK1	0.85650049
50	MAPK7	0.85270227
51	JAK2	0.82711470
52	LYN	0.80957093
53	BMPR2	0.80258883
54	MAP3K5	0.78365921
55	CDK6	0.77178190
56	PDK1	0.76449045
57	GRK1	0.76068971
58	MAP3K12	0.76029200
59	VRK1	0.75603106
60	IGF1R	0.73820965
61	MAP3K14	0.73527318
62	FGFR4	0.73194158
63	SGK2	0.71651694
64	FGFR3	0.71410056
65	CDK4	0.69677836
66	BLK	0.68988889
67	PRKG1	0.66582916
68	MATK	0.64691987
69	MAP2K3	0.62358800
70	PRKAA2	0.58843966
71	HCK	0.58093009
72	MAP3K7	0.57568174
73	PIM1	0.56974487
74	PRKCG	0.55744143
75	ZAK	0.54772041
76	PDPK1	0.54633432
77	CSK	0.54489280
78	PRKACA	0.53919853
79	PRKCB	0.52328644
80	MAPK4	0.52152960
81	PRKG2	0.51876388
82	PRKCA	0.51527744
83	JAK3	0.49392886
84	ABL2	0.47720448
85	BRAF	0.47156211
86	MAPK15	0.46449363
87	PRKCZ	0.46414862
88	SGK223	0.45101709
89	SGK494	0.45101709
90	CSNK1A1	0.44946168
91	MAPK3	0.43794170
92	PRKD3	0.42852377
93	PRKCE	0.41594605
94	SGK3	0.40299665
95	MST1R	0.40130605
96	PBK	0.40050953
97	TIE1	0.39975569
98	SGK1	0.37929587
99	NLK	0.36629400
100	RPS6KA3	0.36300465

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.30860814
2	Caffeine metabolism_Homo sapiens_hsa00232	3.95190509
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.59824823
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.53759690
5	Complement and coagulation cascades_Homo sapiens_hsa04610	3.52700041
6	Retinol metabolism_Homo sapiens_hsa00830	3.43658637
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.41351142
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	3.10352367
9	Chemical carcinogenesis_Homo sapiens_hsa05204	3.03877406
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.00285226
11	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.97188193
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.78574116
13	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.71814041
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.52178067
15	Phenylalanine metabolism_Homo sapiens_hsa00360	2.51744227
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.47284121
17	Fatty acid degradation_Homo sapiens_hsa00071	2.16715236
18	Butanoate metabolism_Homo sapiens_hsa00650	2.05438400
19	Tyrosine metabolism_Homo sapiens_hsa00350	2.00157545
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99526188
21	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.98029668
22	Bile secretion_Homo sapiens_hsa04976	1.86375766
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.78800815
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67843780
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64355434
26	Peroxisome_Homo sapiens_hsa04146	1.61083762
27	Histidine metabolism_Homo sapiens_hsa00340	1.52211725
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.49687092
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.44373662
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37226678
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26383151
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25665656
33	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.23716867
34	PPAR signaling pathway_Homo sapiens_hsa03320	1.19940086
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17121794
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15051961
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.14428602
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.99557846
39	Propanoate metabolism_Homo sapiens_hsa00640	0.97554855
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.93534246
41	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.88958161
42	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81571872
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79050824
44	Sulfur metabolism_Homo sapiens_hsa00920	0.77200267
45	Sulfur relay system_Homo sapiens_hsa04122	0.75071978
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.74549630
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.74519185
48	Carbon metabolism_Homo sapiens_hsa01200	0.74201685
49	One carbon pool by folate_Homo sapiens_hsa00670	0.72933535
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71529228
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.70125960
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.69599893
53	ABC transporters_Homo sapiens_hsa02010	0.68828355
54	Prion diseases_Homo sapiens_hsa05020	0.67338828
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52397338
56	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51685637
57	Metabolic pathways_Homo sapiens_hsa01100	0.44894949
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36282484
59	Fatty acid elongation_Homo sapiens_hsa00062	0.35435901
60	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.34379665
61	Lysine degradation_Homo sapiens_hsa00310	0.31175106
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.30657481
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29515014
64	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.26917970
65	Pertussis_Homo sapiens_hsa05133	0.25039888
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.21832480
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.18096767
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.17676082
69	African trypanosomiasis_Homo sapiens_hsa05143	0.16399515
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.15222009
71	Insulin resistance_Homo sapiens_hsa04931	0.13493644
72	Glutathione metabolism_Homo sapiens_hsa00480	0.13007995
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.10276512
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.09663147
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.06269275
76	Serotonergic synapse_Homo sapiens_hsa04726	0.05394829
77	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.04043185
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.03957618
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.03627934
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.00854531
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.00741725
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	-0.1608872
83	AMPK signaling pathway_Homo sapiens_hsa04152	-0.1571295
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	-0.1468660
85	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1358300
86	Type I diabetes mellitus_Homo sapiens_hsa04940	-0.1343022
87	Folate biosynthesis_Homo sapiens_hsa00790	-0.1195603
88	Graft-versus-host disease_Homo sapiens_hsa05332	-0.1101549
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	-0.1079704
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1071816
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.1069950
92	Pentose phosphate pathway_Homo sapiens_hsa00030	-0.0955898
93	Mineral absorption_Homo sapiens_hsa04978	-0.0948665
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0790751
95	Allograft rejection_Homo sapiens_hsa05330	-0.0719147
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	-0.0687022
97	Circadian rhythm_Homo sapiens_hsa04710	-0.0406582
98	Other glycan degradation_Homo sapiens_hsa00511	-0.0345912
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0224564
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.0089331

NBPF13P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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