NBPF17P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)6.05968090
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81416661
3behavioral response to nicotine (GO:0035095)4.78127649
4ATP synthesis coupled proton transport (GO:0015986)4.75154526
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75154526
6positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.58294596
7ribosomal small subunit assembly (GO:0000028)4.47389771
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.41218864
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.41218864
10regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.29888386
11platelet dense granule organization (GO:0060155)4.29179581
12growth hormone receptor signaling pathway (GO:0060396)4.09882850
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.03241277
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.90838409
15GPI anchor biosynthetic process (GO:0006506)3.82377710
16GPI anchor metabolic process (GO:0006505)3.72479473
17respiratory chain complex IV assembly (GO:0008535)3.71150417
18cellular response to growth hormone stimulus (GO:0071378)3.66673687
19positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.61524664
20DNA deamination (GO:0045006)3.55521151
21viral transcription (GO:0019083)3.55031428
22chaperone-mediated protein transport (GO:0072321)3.53688392
23translational termination (GO:0006415)3.51249593
24preassembly of GPI anchor in ER membrane (GO:0016254)3.43653191
25protein polyglutamylation (GO:0018095)3.37259693
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.31843253
27positive regulation of mast cell degranulation (GO:0043306)3.31843253
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31215408
29regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.30941210
30fucose catabolic process (GO:0019317)3.25636846
31L-fucose metabolic process (GO:0042354)3.25636846
32L-fucose catabolic process (GO:0042355)3.25636846
33respiratory electron transport chain (GO:0022904)3.22825971
34electron transport chain (GO:0022900)3.21084308
35dopamine transport (GO:0015872)3.20552896
36regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.15799621
37positive regulation of mast cell activation (GO:0033005)3.09801128
38positive regulation of prostaglandin secretion (GO:0032308)3.08955490
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07341564
40ribosomal large subunit biogenesis (GO:0042273)3.07318430
41indolalkylamine metabolic process (GO:0006586)3.06033676
42GTP biosynthetic process (GO:0006183)3.05159695
43epithelial cilium movement (GO:0003351)3.04106108
44cotranslational protein targeting to membrane (GO:0006613)3.03330563
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02992196
46hydrogen ion transmembrane transport (GO:1902600)3.02251487
47piRNA metabolic process (GO:0034587)3.01628707
48protein targeting to ER (GO:0045047)2.99912283
49otic vesicle formation (GO:0030916)2.99474271
50cytochrome complex assembly (GO:0017004)2.98885127
51regulation of cilium movement (GO:0003352)2.96537720
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93279771
53maturation of SSU-rRNA (GO:0030490)2.91698947
54kidney morphogenesis (GO:0060993)2.91638249
55establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91579909
56regulation of heat generation (GO:0031650)2.90225463
57protein localization to endoplasmic reticulum (GO:0070972)2.89800277
58protein complex biogenesis (GO:0070271)2.88572203
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86359291
60translational elongation (GO:0006414)2.83602388
61axoneme assembly (GO:0035082)2.77666747
62proton transport (GO:0015992)2.77089718
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76065718
64sulfation (GO:0051923)2.75569383
65hydrogen transport (GO:0006818)2.71346308
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69548180
67motile cilium assembly (GO:0044458)2.68583934
68negative regulation of mast cell activation (GO:0033004)2.67290126
69indole-containing compound catabolic process (GO:0042436)2.66969995
70indolalkylamine catabolic process (GO:0046218)2.66969995
71tryptophan catabolic process (GO:0006569)2.66969995
72ATP biosynthetic process (GO:0006754)2.66878146
73protein neddylation (GO:0045116)2.65444824
74positive regulation of fatty acid transport (GO:2000193)2.63719320
75male meiosis (GO:0007140)2.63310876
76negative regulation of heart rate (GO:0010459)2.61632135
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.61346189
78NADH dehydrogenase complex assembly (GO:0010257)2.61346189
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61346189
80substrate-independent telencephalic tangential migration (GO:0021826)2.59928847
81substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.59928847
82intraciliary transport (GO:0042073)2.57028491
83viral life cycle (GO:0019058)2.57028312
84mitochondrial respiratory chain complex assembly (GO:0033108)2.55738536
85glycolipid biosynthetic process (GO:0009247)2.54301446
86establishment of protein localization to Golgi (GO:0072600)2.52674565
87positive regulation of heat generation (GO:0031652)2.52518053
88replication fork processing (GO:0031297)2.50214826
89cellular protein complex disassembly (GO:0043624)2.49616554
90tongue development (GO:0043586)2.47990793
91anterograde synaptic vesicle transport (GO:0048490)2.45180219
92positive regulation of T cell cytokine production (GO:0002726)2.44804789
93protein localization to cilium (GO:0061512)2.44585754
94regulation of action potential (GO:0098900)2.44519909
95protein targeting to Golgi (GO:0000042)2.44269584
96pattern specification involved in kidney development (GO:0061004)2.43777747
97somite development (GO:0061053)2.43603196
98C-terminal protein amino acid modification (GO:0018410)2.43602817
99positive regulation of icosanoid secretion (GO:0032305)2.42534712
100regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40940872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59090109
2VDR_22108803_ChIP-Seq_LS180_Human3.71548761
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.32885462
4ZNF274_21170338_ChIP-Seq_K562_Hela2.68938107
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63098090
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.34767792
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32689869
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20329661
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20315480
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.19685438
11TAF15_26573619_Chip-Seq_HEK293_Human2.18966676
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.09990452
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09914726
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06019855
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04883437
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99863031
17P300_19829295_ChIP-Seq_ESCs_Human1.94762889
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89953159
19IGF1R_20145208_ChIP-Seq_DFB_Human1.88048995
20BCAT_22108803_ChIP-Seq_LS180_Human1.86146237
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85107945
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83502628
23FUS_26573619_Chip-Seq_HEK293_Human1.83242670
24GBX2_23144817_ChIP-Seq_PC3_Human1.78658639
25EWS_26573619_Chip-Seq_HEK293_Human1.76715739
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.73065174
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72264702
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68960004
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68211854
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.66255202
31ER_23166858_ChIP-Seq_MCF-7_Human1.64906454
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62271324
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54734875
34ELK1_19687146_ChIP-ChIP_HELA_Human1.46860255
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44713311
36TCF4_22108803_ChIP-Seq_LS180_Human1.43739665
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43377387
38SOX2_19829295_ChIP-Seq_ESCs_Human1.42735781
39NANOG_19829295_ChIP-Seq_ESCs_Human1.42735781
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40750475
41CBP_20019798_ChIP-Seq_JUKART_Human1.40750475
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.40269854
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.39818905
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.37373464
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.35356704
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34636629
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34526989
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33938195
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32814354
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32552131
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32327220
52AR_25329375_ChIP-Seq_VCAP_Human1.29537587
53TP53_22573176_ChIP-Seq_HFKS_Human1.28741011
54SMAD4_21799915_ChIP-Seq_A2780_Human1.28192062
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.26193876
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24986426
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.24917489
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24222829
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.24004065
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23490253
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22458009
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.20626855
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20626855
64AR_20517297_ChIP-Seq_VCAP_Human1.20270085
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19703672
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17845027
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.17545603
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14931071
69P53_22387025_ChIP-Seq_ESCs_Mouse1.14924378
70HTT_18923047_ChIP-ChIP_STHdh_Human1.14121678
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.13166606
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.12685008
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.11342067
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10570513
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08896062
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08725763
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07935970
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07756086
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06924783
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06842000
81MYC_18940864_ChIP-ChIP_HL60_Human1.05818396
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03306204
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.03177810
84VDR_23849224_ChIP-Seq_CD4+_Human1.03079218
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.00981900
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00719889
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99813195
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99685311
89STAT3_23295773_ChIP-Seq_U87_Human0.98263637
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97688363
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97630915
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97630915
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97316925
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.97170916
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.96763649
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94823715
97CMYC_18555785_Chip-Seq_ESCs_Mouse0.93705574
98RUNX2_22187159_ChIP-Seq_PCA_Human0.93309648
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92233354
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92111963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.83736123
2MP0002163_abnormal_gland_morphology3.41284125
3MP0006292_abnormal_olfactory_placode3.17462793
4MP0002102_abnormal_ear_morphology3.11124122
5MP0009379_abnormal_foot_pigmentation2.71465481
6MP0001835_abnormal_antigen_presentation2.47559425
7MP0004885_abnormal_endolymph2.47341761
8MP0003011_delayed_dark_adaptation2.46709886
9MP0000372_irregular_coat_pigmentation2.46111080
10MP0005377_hearing/vestibular/ear_phenot2.37430566
11MP0003878_abnormal_ear_physiology2.37430566
12MP0005379_endocrine/exocrine_gland_phen2.20284183
13MP0003787_abnormal_imprinting2.18493052
14MP0006072_abnormal_retinal_apoptosis2.16511554
15MP0005551_abnormal_eye_electrophysiolog2.14411378
16MP0001986_abnormal_taste_sensitivity2.05879347
17MP0003195_calcinosis2.02567835
18MP0003880_abnormal_central_pattern1.86859365
19MP0000427_abnormal_hair_cycle1.84595665
20MP0004142_abnormal_muscle_tone1.79472461
21MP0005671_abnormal_response_to1.79054407
22MP0005253_abnormal_eye_physiology1.74341131
23MP0008872_abnormal_physiological_respon1.66352596
24MP0003136_yellow_coat_color1.59654282
25MP0003122_maternal_imprinting1.59615483
26MP0001984_abnormal_olfaction1.55355818
27MP0002095_abnormal_skin_pigmentation1.52726367
28MP0003938_abnormal_ear_development1.52241207
29MP0005075_abnormal_melanosome_morpholog1.51962716
30MP0003950_abnormal_plasma_membrane1.46514194
31MP0002638_abnormal_pupillary_reflex1.45002347
32MP0001968_abnormal_touch/_nociception1.42192648
33MP0001529_abnormal_vocalization1.41090528
34MP0008875_abnormal_xenobiotic_pharmacok1.39218694
35MP0010030_abnormal_orbit_morphology1.39010794
36MP0001486_abnormal_startle_reflex1.36151526
37MP0002938_white_spotting1.31369691
38MP0001905_abnormal_dopamine_level1.29372598
39MP0008789_abnormal_olfactory_epithelium1.28523251
40MP0005084_abnormal_gallbladder_morpholo1.26535238
41MP0006276_abnormal_autonomic_nervous1.25212360
42MP0002736_abnormal_nociception_after1.24327055
43MP0002282_abnormal_trachea_morphology1.22050821
44MP0001485_abnormal_pinna_reflex1.21849204
45MP0009745_abnormal_behavioral_response1.21493089
46MP0002233_abnormal_nose_morphology1.16981206
47MP0001440_abnormal_grooming_behavior1.14737698
48MP0002148_abnormal_hypersensitivity_rea1.14690421
49MP0000631_abnormal_neuroendocrine_gland1.12064469
50MP0000383_abnormal_hair_follicle1.11229075
51MP0003121_genomic_imprinting1.10395758
52MP0005646_abnormal_pituitary_gland1.09332492
53MP0002272_abnormal_nervous_system1.05835876
54MP0000778_abnormal_nervous_system1.05117611
55MP0001502_abnormal_circadian_rhythm1.03952662
56MP0002876_abnormal_thyroid_physiology1.03889627
57MP0003724_increased_susceptibility_to1.03769298
58MP0005423_abnormal_somatic_nervous1.03697791
59MP0005195_abnormal_posterior_eye1.01596972
60MP0005408_hypopigmentation0.99971586
61MP0000647_abnormal_sebaceous_gland0.99692589
62MP0002837_dystrophic_cardiac_calcinosis0.98705204
63MP0004381_abnormal_hair_follicle0.98265736
64MP0005248_abnormal_Harderian_gland0.95684637
65MP0000026_abnormal_inner_ear0.95312593
66MP0005499_abnormal_olfactory_system0.95117961
67MP0005394_taste/olfaction_phenotype0.95117961
68MP0001800_abnormal_humoral_immune0.94993895
69MP0000049_abnormal_middle_ear0.94935769
70MP0000015_abnormal_ear_pigmentation0.93196627
71MP0005174_abnormal_tail_pigmentation0.92763876
72MP0004742_abnormal_vestibular_system0.91890965
73MP0001346_abnormal_lacrimal_gland0.91779828
74MP0000639_abnormal_adrenal_gland0.90594250
75MP0001970_abnormal_pain_threshold0.85907907
76MP0002572_abnormal_emotion/affect_behav0.85110945
77MP0002928_abnormal_bile_duct0.84892036
78MP0004019_abnormal_vitamin_homeostasis0.83894579
79MP0005645_abnormal_hypothalamus_physiol0.83201382
80MP0002653_abnormal_ependyma_morphology0.80542292
81MP0009764_decreased_sensitivity_to0.79850180
82MP0001790_abnormal_immune_system0.78656025
83MP0005387_immune_system_phenotype0.78656025
84MP0002277_abnormal_respiratory_mucosa0.77140363
85MP0001293_anophthalmia0.75910813
86MP0001666_abnormal_nutrient_absorption0.75484072
87MP0000613_abnormal_salivary_gland0.75470190
88MP0002723_abnormal_immune_serum0.75079286
89MP0001286_abnormal_eye_development0.74065239
90MP0000230_abnormal_systemic_arterial0.73171214
91MP0002734_abnormal_mechanical_nocicepti0.72175286
92MP0009785_altered_susceptibility_to0.72139828
93MP0009046_muscle_twitch0.71498200
94MP0002064_seizures0.70935223
95MP0002109_abnormal_limb_morphology0.69142425
96MP0005171_absent_coat_pigmentation0.68664796
97MP0001963_abnormal_hearing_physiology0.67811305
98MP0000685_abnormal_immune_system0.66448022
99MP0005391_vision/eye_phenotype0.66194429
100MP0002067_abnormal_sensory_capabilities0.66181648

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.31265633
2Absent/shortened dynein arms (HP:0200106)5.31265633
3Congenital stationary night blindness (HP:0007642)4.22194130
4Pancreatic fibrosis (HP:0100732)3.76864851
5Pancreatic cysts (HP:0001737)3.74563769
6True hermaphroditism (HP:0010459)3.59848764
7Molar tooth sign on MRI (HP:0002419)3.52945182
8Abnormality of midbrain morphology (HP:0002418)3.52945182
9Abnormal rod and cone electroretinograms (HP:0008323)3.45296350
10Abnormal respiratory epithelium morphology (HP:0012253)3.39030447
11Abnormal respiratory motile cilium morphology (HP:0005938)3.39030447
12Acute necrotizing encephalopathy (HP:0006965)3.37367639
13Abnormal ciliary motility (HP:0012262)3.30865288
143-Methylglutaconic aciduria (HP:0003535)3.03380779
15Growth hormone deficiency (HP:0000824)2.98344420
16Mitochondrial inheritance (HP:0001427)2.95857025
17Progressive macrocephaly (HP:0004481)2.92904912
18Acute encephalopathy (HP:0006846)2.91935072
19Increased CSF lactate (HP:0002490)2.90249781
20Abnormality of the phalanges of the 2nd finger (HP:0009541)2.89876371
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.78997433
22Hypoplasia of the fovea (HP:0007750)2.76435369
23Aplasia/Hypoplasia of the fovea (HP:0008060)2.76435369
24Abolished electroretinogram (ERG) (HP:0000550)2.71097669
25Abnormal mitochondria in muscle tissue (HP:0008316)2.70024524
26Septo-optic dysplasia (HP:0100842)2.68991660
27Abnormality of the labia minora (HP:0012880)2.66931615
28Volvulus (HP:0002580)2.62636120
29Cystic liver disease (HP:0006706)2.59876539
30Abnormal respiratory motile cilium physiology (HP:0012261)2.55620269
31Abnormality of alanine metabolism (HP:0010916)2.45116789
32Hyperalaninemia (HP:0003348)2.45116789
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45116789
34Nephronophthisis (HP:0000090)2.43964978
35Chronic hepatic failure (HP:0100626)2.42166244
36Metaphyseal dysplasia (HP:0100255)2.41771037
37Abnormality of the renal cortex (HP:0011035)2.41219403
38Abnormality of the renal medulla (HP:0100957)2.40216167
39Congenital, generalized hypertrichosis (HP:0004540)2.37166906
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37149685
41Decreased central vision (HP:0007663)2.36931645
42Abnormality of the fovea (HP:0000493)2.36913166
43Medial flaring of the eyebrow (HP:0010747)2.33680916
44Type II lissencephaly (HP:0007260)2.33424738
45Constricted visual fields (HP:0001133)2.29666291
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29357874
47Hypothermia (HP:0002045)2.27997748
48Male pseudohermaphroditism (HP:0000037)2.24368910
49Disproportionate short-trunk short stature (HP:0003521)2.20285904
50Type 2 muscle fiber atrophy (HP:0003554)2.19673208
51Increased hepatocellular lipid droplets (HP:0006565)2.18928067
52Attenuation of retinal blood vessels (HP:0007843)2.18089141
53Lipid accumulation in hepatocytes (HP:0006561)2.17530730
54Hepatocellular necrosis (HP:0001404)2.16457001
55Optic nerve hypoplasia (HP:0000609)2.12786318
56Abnormality of cells of the erythroid lineage (HP:0012130)2.12409713
57Optic disc pallor (HP:0000543)2.09532450
58Reticulocytopenia (HP:0001896)2.08294930
59Cerebellar dysplasia (HP:0007033)2.05332953
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.05266565
61Anencephaly (HP:0002323)2.04891729
62Oligodactyly (hands) (HP:0001180)2.03729577
63Large for gestational age (HP:0001520)2.03174141
64Bilateral microphthalmos (HP:0007633)2.01763861
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97188299
66Sclerocornea (HP:0000647)1.96637646
67Hyperventilation (HP:0002883)1.95907132
68Stenosis of the external auditory canal (HP:0000402)1.94374161
69Pendular nystagmus (HP:0012043)1.93929967
70Hypomagnesemia (HP:0002917)1.93856460
71Hepatic necrosis (HP:0002605)1.91883770
72Abnormal number of erythroid precursors (HP:0012131)1.90180045
73Rhinitis (HP:0012384)1.88156393
74Cerebral edema (HP:0002181)1.87928079
75Abnormal hemoglobin (HP:0011902)1.84635718
76Abnormal biliary tract physiology (HP:0012439)1.83715502
77Bile duct proliferation (HP:0001408)1.83715502
78Lissencephaly (HP:0001339)1.82005506
79Hypoproteinemia (HP:0003075)1.81081126
80Cerebral palsy (HP:0100021)1.80837470
81Macrocytic anemia (HP:0001972)1.79696999
82Intestinal atresia (HP:0011100)1.79338293
83Polyuria (HP:0000103)1.79031749
84Absent septum pellucidum (HP:0001331)1.78745050
85Abnormal drinking behavior (HP:0030082)1.78662841
86Polydipsia (HP:0001959)1.78662841
87Limb dystonia (HP:0002451)1.78504689
88Furrowed tongue (HP:0000221)1.75847778
89Increased corneal curvature (HP:0100692)1.74030223
90Keratoconus (HP:0000563)1.74030223
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.72804952
92Leukodystrophy (HP:0002415)1.72341217
93Aplasia/Hypoplasia of the macula (HP:0008059)1.72192814
94Rib fusion (HP:0000902)1.71909866
95Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71619010
96Exertional dyspnea (HP:0002875)1.70256348
97Aplasia/Hypoplasia affecting the retina (HP:0008061)1.65236238
98Muscle fiber atrophy (HP:0100295)1.64850281
99Postaxial hand polydactyly (HP:0001162)1.64405232
100Hypoplasia of the radius (HP:0002984)1.64398854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K127.08104092
2TRIM283.34976143
3STK162.89135103
4BMPR22.78797947
5MAP3K112.62824593
6FRK2.42001486
7WNK32.41426889
8CDK192.19459962
9PINK12.05956339
10CDK81.99492882
11PIK3CG1.96438804
12WNK41.77276499
13GRK11.67760700
14TXK1.63111106
15ADRBK21.62779297
16RIPK41.58107761
17MAP4K21.55739427
18NUAK11.50787071
19DYRK21.39375759
20MAP2K41.38801685
21INSRR1.38674428
22TLK11.26655068
23BCKDK1.24166008
24OXSR11.23291660
25BLK1.21356999
26GRK61.19045694
27TAOK31.18145230
28STK391.12285124
29PTK2B1.07824471
30PLK21.04847294
31BMPR1B1.04399375
32TIE11.04010913
33MYLK1.02903784
34ACVR1B1.01269848
35GRK70.99135285
36MAP3K40.98854801
37DAPK30.94789463
38MAP3K90.90393600
39PLK40.87277559
40TNIK0.86766952
41PDK20.85865891
42IKBKB0.84209568
43ADRBK10.83390341
44MATK0.83353778
45GRK50.81588481
46CASK0.81041669
47EPHB20.80848880
48FGFR20.80713152
49TEC0.80234785
50EPHA40.76473317
51PRKCE0.75215178
52SYK0.73922464
53KIT0.73494796
54JAK30.72495351
55VRK20.71514578
56FES0.69461470
57MAP3K50.68400178
58NEK10.65592161
59ILK0.63195928
60MAPK130.62670476
61PAK30.62198110
62ERBB20.60158380
63ERBB30.60037313
64ZAK0.59519687
65PKN10.59493183
66CSF1R0.58958914
67MAP4K10.58291784
68MAP3K130.58175003
69DAPK10.57861729
70CAMKK20.57789910
71TGFBR20.55665411
72LYN0.54485238
73PRKCG0.54343477
74DAPK20.52691792
75BRSK20.50644494
76STK110.48535225
77CSNK1G20.45859945
78MAP2K70.45822241
79LCK0.45783475
80PRKCQ0.45407484
81MAP2K60.45100676
82NLK0.43803246
83OBSCN0.43541956
84RPS6KA50.42584856
85PLK30.42504188
86CDC70.41886490
87PRKG10.41492053
88CSNK1G30.39858482
89HIPK20.37215331
90CSNK1G10.36000345
91MAP2K20.35338550
92BUB10.35056967
93PRKACA0.34890957
94VRK10.34591421
95PASK0.34333168
96IKBKE0.34204397
97NME10.33264339
98CAMK2A0.32145376
99PRKCA0.31859426
100IGF1R0.31415274

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.01938345
2Graft-versus-host disease_Homo sapiens_hsa053323.64092463
3Oxidative phosphorylation_Homo sapiens_hsa001903.48346476
4Ribosome_Homo sapiens_hsa030103.13913853
5Allograft rejection_Homo sapiens_hsa053303.12811684
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.98485686
7Autoimmune thyroid disease_Homo sapiens_hsa053202.93392826
8Type I diabetes mellitus_Homo sapiens_hsa049402.81777618
9Parkinsons disease_Homo sapiens_hsa050122.79947148
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58623131
11Caffeine metabolism_Homo sapiens_hsa002322.50687535
12Proteasome_Homo sapiens_hsa030502.18063298
13Antigen processing and presentation_Homo sapiens_hsa046122.04901574
14Alzheimers disease_Homo sapiens_hsa050101.89605600
15Phototransduction_Homo sapiens_hsa047441.83119436
16Rheumatoid arthritis_Homo sapiens_hsa053231.78880298
17Cardiac muscle contraction_Homo sapiens_hsa042601.76446283
18Huntingtons disease_Homo sapiens_hsa050161.63105781
19Protein export_Homo sapiens_hsa030601.57947498
20Staphylococcus aureus infection_Homo sapiens_hsa051501.57494032
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56380909
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51115615
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37360716
24Olfactory transduction_Homo sapiens_hsa047401.32631580
25Basal transcription factors_Homo sapiens_hsa030221.30729733
26One carbon pool by folate_Homo sapiens_hsa006701.29007400
27Tryptophan metabolism_Homo sapiens_hsa003801.28378581
28Collecting duct acid secretion_Homo sapiens_hsa049661.28226788
29Viral myocarditis_Homo sapiens_hsa054161.25588925
30Linoleic acid metabolism_Homo sapiens_hsa005911.24895333
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21563689
32Nicotine addiction_Homo sapiens_hsa050331.21067403
33Leishmaniasis_Homo sapiens_hsa051401.20047317
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16918775
35Regulation of autophagy_Homo sapiens_hsa041401.16647673
36Nitrogen metabolism_Homo sapiens_hsa009101.07988376
37RNA polymerase_Homo sapiens_hsa030201.05923011
38RNA degradation_Homo sapiens_hsa030181.04527668
39Chemical carcinogenesis_Homo sapiens_hsa052040.98684797
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93411847
41Morphine addiction_Homo sapiens_hsa050320.90954226
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90284496
43Peroxisome_Homo sapiens_hsa041460.90140343
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85858177
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81084318
46Tuberculosis_Homo sapiens_hsa051520.79288839
47Mismatch repair_Homo sapiens_hsa034300.78021371
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77989146
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77173149
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73203899
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72772178
52Arachidonic acid metabolism_Homo sapiens_hsa005900.71784869
53Homologous recombination_Homo sapiens_hsa034400.71385201
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70247466
55Butanoate metabolism_Homo sapiens_hsa006500.69424841
56Retinol metabolism_Homo sapiens_hsa008300.68560779
57Propanoate metabolism_Homo sapiens_hsa006400.63883160
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.63299415
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.63168095
60Hematopoietic cell lineage_Homo sapiens_hsa046400.59250919
61Glutathione metabolism_Homo sapiens_hsa004800.59166093
62GABAergic synapse_Homo sapiens_hsa047270.58777566
63Circadian entrainment_Homo sapiens_hsa047130.55566950
64Glutamatergic synapse_Homo sapiens_hsa047240.54280254
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54200071
66Primary immunodeficiency_Homo sapiens_hsa053400.53965319
67Hedgehog signaling pathway_Homo sapiens_hsa043400.53757800
68Systemic lupus erythematosus_Homo sapiens_hsa053220.52739920
69Nucleotide excision repair_Homo sapiens_hsa034200.52090675
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51242398
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51174521
72Fanconi anemia pathway_Homo sapiens_hsa034600.48963808
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.48622575
74Taste transduction_Homo sapiens_hsa047420.48214314
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48048185
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46390150
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44341405
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.43825985
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42762090
80Serotonergic synapse_Homo sapiens_hsa047260.42295434
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40804090
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38102507
83Purine metabolism_Homo sapiens_hsa002300.37054365
84ABC transporters_Homo sapiens_hsa020100.34701534
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32850602
86Fat digestion and absorption_Homo sapiens_hsa049750.32267383
87Basal cell carcinoma_Homo sapiens_hsa052170.31961490
88Circadian rhythm_Homo sapiens_hsa047100.30745503
89Phagosome_Homo sapiens_hsa041450.30444614
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30308445
91Ether lipid metabolism_Homo sapiens_hsa005650.30180674
92Insulin secretion_Homo sapiens_hsa049110.27363100
93Metabolic pathways_Homo sapiens_hsa011000.27232894
94Fatty acid degradation_Homo sapiens_hsa000710.22525638
95Salivary secretion_Homo sapiens_hsa049700.22325554
96Calcium signaling pathway_Homo sapiens_hsa040200.20097588
97Cholinergic synapse_Homo sapiens_hsa047250.20034438
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19984956
99RNA transport_Homo sapiens_hsa030130.19836154
100Oxytocin signaling pathway_Homo sapiens_hsa049210.19353368

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