NBPF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.69845384
2regulation of gamma-delta T cell activation (GO:0046643)4.46150123
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.43016132
4negative regulation of cell killing (GO:0031342)4.43016132
5cellular extravasation (GO:0045123)4.36648286
6response to peptidoglycan (GO:0032494)4.22743669
7regulation of B cell receptor signaling pathway (GO:0050855)4.18305515
8detection of molecule of bacterial origin (GO:0032490)4.11479404
9negative regulation of interleukin-12 production (GO:0032695)4.05062232
10modulation by symbiont of host defense response (GO:0052031)3.92844062
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.92844062
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.92844062
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.92844062
14modulation by symbiont of host immune response (GO:0052553)3.92844062
15positive regulation by symbiont of host defense response (GO:0052509)3.92844062
16regulation of gamma-delta T cell differentiation (GO:0045586)3.90445844
17macrophage activation involved in immune response (GO:0002281)3.88272920
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84922592
19negative thymic T cell selection (GO:0045060)3.80656642
20negative T cell selection (GO:0043383)3.76709142
21leukocyte aggregation (GO:0070486)3.64419254
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58586899
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54359564
24response to muramyl dipeptide (GO:0032495)3.53190414
25detection of other organism (GO:0098543)3.50013964
26cellular response to ethanol (GO:0071361)3.49070677
27neutrophil mediated immunity (GO:0002446)3.45022529
28microglial cell activation (GO:0001774)3.44947599
29negative regulation of T cell mediated immunity (GO:0002710)3.43969434
30activated T cell proliferation (GO:0050798)3.40882292
31detection of external biotic stimulus (GO:0098581)3.31474301
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30790911
33neutrophil activation involved in immune response (GO:0002283)3.26972959
34antigen processing and presentation of endogenous antigen (GO:0019883)3.26237164
35positive T cell selection (GO:0043368)3.22136557
36positive regulation of granulocyte differentiation (GO:0030854)3.15624272
37macrophage activation (GO:0042116)3.15108519
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14651543
39detection of biotic stimulus (GO:0009595)3.14185269
40T cell selection (GO:0045058)3.12061228
41interferon-gamma production (GO:0032609)3.12002077
42regulation of interleukin-12 biosynthetic process (GO:0045075)3.09979399
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07997266
44myeloid cell activation involved in immune response (GO:0002275)3.05508761
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.05484588
46detection of bacterium (GO:0016045)3.05205149
47positive thymic T cell selection (GO:0045059)3.05002187
48regulation of interferon-beta biosynthetic process (GO:0045357)3.04405633
49T cell migration (GO:0072678)3.04097599
50phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.02997616
51hepatocyte apoptotic process (GO:0097284)3.02716806
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96706365
53histone H3-K36 demethylation (GO:0070544)2.95597695
54histone H3-K4 trimethylation (GO:0080182)2.94999649
55myeloid leukocyte mediated immunity (GO:0002444)2.93318215
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92664817
57negative regulation of T-helper cell differentiation (GO:0045623)2.87823735
58negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87823735
59regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.85491932
60regulation of tolerance induction (GO:0002643)2.83912449
61regulation of B cell differentiation (GO:0045577)2.81360825
62neutrophil activation (GO:0042119)2.78071370
63positive regulation of tolerance induction (GO:0002645)2.77488910
64defense response to protozoan (GO:0042832)2.76591598
65regulation of alpha-beta T cell proliferation (GO:0046640)2.76232637
66dendritic cell migration (GO:0036336)2.76109362
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74927482
68positive regulation of cellular amide metabolic process (GO:0034250)2.74633652
69regulation of T cell tolerance induction (GO:0002664)2.73547146
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71281861
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71159069
72response to host (GO:0075136)2.71159069
73response to host defenses (GO:0052200)2.71159069
74regulation of mast cell activation (GO:0033003)2.70650242
75regulation of MHC class I biosynthetic process (GO:0045343)2.70572095
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69571642
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.69154309
78negative regulation of leukocyte mediated immunity (GO:0002704)2.68047542
79response to host immune response (GO:0052572)2.66453241
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66453241
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66431976
82response to protozoan (GO:0001562)2.66138610
83B cell receptor signaling pathway (GO:0050853)2.64333963
84germinal center formation (GO:0002467)2.64109284
85granulocyte activation (GO:0036230)2.62971367
86negative regulation of B cell proliferation (GO:0030889)2.61270211
87thymic T cell selection (GO:0045061)2.60951086
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.60239229
89T-helper cell differentiation (GO:0042093)2.60239229
90establishment of protein localization to Golgi (GO:0072600)2.60237105
91negative regulation of interleukin-6 production (GO:0032715)2.59427993
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58847999
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58038098
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56879263
95positive regulation of interleukin-1 beta secretion (GO:0050718)2.56550601
96immunoglobulin mediated immune response (GO:0016064)2.55357865
97negative regulation of alpha-beta T cell activation (GO:0046636)2.54945052
98regulation of T-helper 2 cell differentiation (GO:0045628)2.54043255
99production of molecular mediator involved in inflammatory response (GO:0002532)2.53854032
100response to type I interferon (GO:0034340)2.53329386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.97034772
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.91815872
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.30338054
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.31502521
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.14907603
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94826246
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.89349379
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.75134670
9RUNX_20019798_ChIP-Seq_JUKART_Human2.72003372
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69067653
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52609741
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.52580685
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48603683
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47688427
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45561250
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43089766
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35550157
18VDR_24787735_ChIP-Seq_THP-1_Human2.31763040
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25363907
20SCL_19346495_ChIP-Seq_HPC-7_Human2.18552735
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15968749
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12192970
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.12132958
24MYB_26560356_Chip-Seq_TH2_Human2.03417862
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93809880
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88451699
27SPI1_23127762_ChIP-Seq_K562_Human1.85104025
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81352182
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76722258
30MYB_26560356_Chip-Seq_TH1_Human1.71113419
31SPI1_23547873_ChIP-Seq_NB4_Human1.57743638
32GATA1_22025678_ChIP-Seq_K562_Human1.56518574
33TP53_16413492_ChIP-PET_HCT116_Human1.55502352
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.53775825
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53166344
36VDR_24763502_ChIP-Seq_THP-1_Human1.52284676
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48761682
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47443969
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46942623
40GATA3_27048872_Chip-Seq_THYMUS_Human1.45333047
41GATA3_26560356_Chip-Seq_TH2_Human1.43824649
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.39537022
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31843669
44AHR_22903824_ChIP-Seq_MCF-7_Human1.31244711
45PU_27001747_Chip-Seq_BMDM_Mouse1.31157774
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30496339
47MAF_26560356_Chip-Seq_TH1_Human1.28243472
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24735630
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23944128
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.22054925
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21728500
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15737344
53ER_23166858_ChIP-Seq_MCF-7_Human1.12836800
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08214030
55TCF7_22412390_ChIP-Seq_EML_Mouse1.05669984
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04395868
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04299204
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04299204
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04232236
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.03769517
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03709368
62UTX_26944678_Chip-Seq_JUKART_Human1.02321291
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.01489299
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00202367
65CJUN_26792858_Chip-Seq_BT549_Human0.99403423
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99232599
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98313889
68CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98297862
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98123738
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98022441
71ESR2_21235772_ChIP-Seq_MCF-7_Human0.96009442
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94437692
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94242758
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91604923
75PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90609391
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89924291
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89842755
78BRD4_25478319_ChIP-Seq_HGPS_Human0.88781811
79STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88548398
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.86421108
81SMRT_27268052_Chip-Seq_Bcells_Human0.86180202
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.85919828
83MAF_26560356_Chip-Seq_TH2_Human0.85573122
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84081511
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.83591549
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83235645
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82188168
88SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81691046
89GATA2_19941826_ChIP-Seq_K562_Human0.81185932
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81071228
91VDR_21846776_ChIP-Seq_THP-1_Human0.80938525
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80055904
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79788079
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.79465985
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.79060923
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78951984
97BCAT_22108803_ChIP-Seq_LS180_Human0.78398408
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78346555
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78181423
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.77392398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.69180073
2MP0003724_increased_susceptibility_to3.27166194
3MP0000569_abnormal_digit_pigmentation3.22210400
4MP0003436_decreased_susceptibility_to2.99030199
5MP0003303_peritoneal_inflammation2.96406380
6MP0003763_abnormal_thymus_physiology2.65841410
7MP0001800_abnormal_humoral_immune2.54911736
8MP0002419_abnormal_innate_immunity2.53995142
9MP0006082_CNS_inflammation2.37818040
10MP0003300_gastrointestinal_ulcer2.33315565
11MP0008057_abnormal_DNA_replication2.32938987
12MP0009785_altered_susceptibility_to2.28613101
13MP0005000_abnormal_immune_tolerance2.28206219
14MP0002452_abnormal_antigen_presenting2.24109843
15MP0000685_abnormal_immune_system2.23244483
16MP0002723_abnormal_immune_serum2.22704064
17MP0005671_abnormal_response_to2.19484695
18MP0003828_pulmonary_edema2.17976532
19MP0004381_abnormal_hair_follicle2.17411672
20MP0005025_abnormal_response_to2.16432099
21MP0002148_abnormal_hypersensitivity_rea2.11187892
22MP0005387_immune_system_phenotype2.06213483
23MP0001790_abnormal_immune_system2.06213483
24MP0002420_abnormal_adaptive_immunity2.00833239
25MP0001819_abnormal_immune_cell1.98856521
26MP0004947_skin_inflammation1.95244977
27MP0002405_respiratory_system_inflammati1.93628379
28MP0003172_abnormal_lysosome_physiology1.81816784
29MP0001853_heart_inflammation1.79598332
30MP0004883_abnormal_blood_vessel1.72355174
31MP0010155_abnormal_intestine_physiology1.69046786
32MP0005310_abnormal_salivary_gland1.68696405
33MP0002396_abnormal_hematopoietic_system1.66760341
34MP0002166_altered_tumor_susceptibility1.62432440
35MP0000015_abnormal_ear_pigmentation1.61883139
36MP0003950_abnormal_plasma_membrane1.61640277
37MP0008260_abnormal_autophagy1.58183084
38MP0002398_abnormal_bone_marrow1.57324488
39MP0004808_abnormal_hematopoietic_stem1.56712568
40MP0000716_abnormal_immune_system1.55323663
41MP0003091_abnormal_cell_migration1.54353794
42MP0008004_abnormal_stomach_pH1.53802009
43MP0001533_abnormal_skeleton_physiology1.53529936
44MP0002998_abnormal_bone_remodeling1.51733976
45MP0005397_hematopoietic_system_phenotyp1.51504142
46MP0001545_abnormal_hematopoietic_system1.51504142
47MP0003866_abnormal_defecation1.48659341
48MP0005164_abnormal_response_to1.47185812
49MP0001851_eye_inflammation1.46738708
50MP0001845_abnormal_inflammatory_respons1.45979582
51MP0009278_abnormal_bone_marrow1.43762487
52MP0002009_preneoplasia1.42187369
53MP0000465_gastrointestinal_hemorrhage1.40585629
54MP0003656_abnormal_erythrocyte_physiolo1.39283321
55MP0009764_decreased_sensitivity_to1.32292077
56MP0005076_abnormal_cell_differentiation1.32221777
57MP0005174_abnormal_tail_pigmentation1.30599438
58MP0000689_abnormal_spleen_morphology1.29901448
59MP0000703_abnormal_thymus_morphology1.28394065
60MP0002722_abnormal_immune_system1.28039393
61MP0005464_abnormal_platelet_physiology1.27459859
62MP0003191_abnormal_cellular_cholesterol1.21877681
63MP0002006_tumorigenesis1.21173761
64MP0000371_diluted_coat_color1.20223622
65MP0003690_abnormal_glial_cell1.16817960
66MP0005058_abnormal_lysosome_morphology1.15933059
67MP0006054_spinal_hemorrhage1.14685317
68MP0002429_abnormal_blood_cell1.14290389
69MP0000383_abnormal_hair_follicle1.14240116
70MP0000858_altered_metastatic_potential1.11997849
71MP0002254_reproductive_system_inflammat1.11449416
72MP0008469_abnormal_protein_level1.08456810
73MP0003045_fibrosis1.07253296
74MP0010678_abnormal_skin_adnexa1.07139593
75MP0003448_altered_tumor_morphology1.04201581
76MP0002933_joint_inflammation1.02145524
77MP0005075_abnormal_melanosome_morpholog1.00339965
78MP0005451_abnormal_body_composition0.98205656
79MP0009333_abnormal_splenocyte_physiolog0.95693631
80MP0003183_abnormal_peptide_metabolism0.94188834
81MP0003453_abnormal_keratinocyte_physiol0.93887918
82MP0002332_abnormal_exercise_endurance0.93604272
83MP0001873_stomach_inflammation0.91174589
84MP0005408_hypopigmentation0.86386461
85MP0005166_decreased_susceptibility_to0.84365328
86MP0008961_abnormal_basal_metabolism0.76180674
87MP0000249_abnormal_blood_vessel0.76073643
88MP0002168_other_aberrant_phenotype0.75860440
89MP0002132_abnormal_respiratory_system0.74075300
90MP0001663_abnormal_digestive_system0.73059458
91MP0005390_skeleton_phenotype0.72976618
92MP0003279_aneurysm0.72903043
93MP0010352_gastrointestinal_tract_polyps0.72632431
94MP0000427_abnormal_hair_cycle0.71041408
95MP0003795_abnormal_bone_structure0.69769181
96MP0005275_abnormal_skin_tensile0.69736627
97MP0009115_abnormal_fat_cell0.69522591
98MP0009763_increased_sensitivity_to0.69070970
99MP0003705_abnormal_hypodermis_morpholog0.67037165
100MP0001958_emphysema0.66879975

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.77854923
2Eczematoid dermatitis (HP:0000976)4.41286979
3Recurrent abscess formation (HP:0002722)4.39796101
4Retrobulbar optic neuritis (HP:0100654)4.30041743
5Optic neuritis (HP:0100653)4.30041743
6T lymphocytopenia (HP:0005403)4.08340773
7Myositis (HP:0100614)3.98917852
8Orchitis (HP:0100796)3.97928011
9Abnormality of T cell number (HP:0011839)3.80253135
10Stomatitis (HP:0010280)3.75434239
11Recurrent fungal infections (HP:0002841)3.61236287
12Absent frontal sinuses (HP:0002688)3.45825882
13Elevated erythrocyte sedimentation rate (HP:0003565)3.34545319
14Abnormality of macrophages (HP:0004311)3.34030029
15Spondylolisthesis (HP:0003302)3.25825466
16Mediastinal lymphadenopathy (HP:0100721)3.15410884
17Recurrent skin infections (HP:0001581)3.14963440
18Chronic mucocutaneous candidiasis (HP:0002728)3.14468978
19Recurrent cutaneous fungal infections (HP:0011370)3.14468978
20Recurrent gram-negative bacterial infections (HP:0005420)3.12742559
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.00833143
22Keratoconjunctivitis sicca (HP:0001097)2.99117810
23Recurrent viral infections (HP:0004429)2.98631314
24Gastrointestinal infarctions (HP:0005244)2.92684488
25Stomach cancer (HP:0012126)2.82025989
26Keratoconjunctivitis (HP:0001096)2.80796455
27Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.80560301
28Abnormality of the fingertips (HP:0001211)2.74188316
29Gingivitis (HP:0000230)2.73913827
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72957932
31Pulmonary infiltrates (HP:0002113)2.71818979
32Colitis (HP:0002583)2.66075734
33Leukocytosis (HP:0001974)2.65390483
34Pustule (HP:0200039)2.65312468
35Hemoptysis (HP:0002105)2.61155187
36Subacute progressive viral hepatitis (HP:0006572)2.58524767
37Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.53852717
38Vasculitis (HP:0002633)2.48071414
39Arterial thrombosis (HP:0004420)2.47475155
40Abnormality of T cells (HP:0002843)2.42901854
41Narrow palate (HP:0000189)2.42698220
42Abnormality of glycolipid metabolism (HP:0010969)2.41850661
43Abnormality of liposaccharide metabolism (HP:0010968)2.41850661
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.41850661
45Autoimmune thrombocytopenia (HP:0001973)2.35737406
46Syringomyelia (HP:0003396)2.35081908
47Spinal cord lesions (HP:0100561)2.35081908
48Autoimmune hemolytic anemia (HP:0001890)2.34335535
49Meningitis (HP:0001287)2.33395750
50Chest pain (HP:0100749)2.31990282
51Peritonitis (HP:0002586)2.31367520
52Inflammation of the large intestine (HP:0002037)2.28617448
53Eosinophilia (HP:0001880)2.27155487
54Gingival bleeding (HP:0000225)2.26947721
55Prolonged bleeding time (HP:0003010)2.26551657
56Viral hepatitis (HP:0006562)2.26056944
57Spontaneous hematomas (HP:0007420)2.25963178
58Periodontitis (HP:0000704)2.25365237
59Hematochezia (HP:0002573)2.24688990
60Neoplasm of the tracheobronchial system (HP:0100552)2.21212696
61Panhypogammaglobulinemia (HP:0003139)2.20991950
62Encephalitis (HP:0002383)2.17492160
63Abnormality of the frontal sinuses (HP:0002687)2.17198183
64Abnormality of incisor morphology (HP:0011063)2.16719021
65Dislocated radial head (HP:0003083)2.13963620
66Increased cerebral lipofuscin (HP:0011813)2.11012931
67Gastrointestinal inflammation (HP:0004386)2.08918384
68Granulocytopenia (HP:0001913)2.08731225
69Recurrent bronchitis (HP:0002837)2.07287454
70Long eyelashes (HP:0000527)2.04995817
71Increased IgE level (HP:0003212)2.03588173
72Abnormality of the radial head (HP:0003995)1.99436382
73Pulmonary artery stenosis (HP:0004415)1.99365625
74Abnormality of eosinophils (HP:0001879)1.97403531
75Osteolytic defects of the hand bones (HP:0009699)1.96692067
76Osteolytic defects of the phalanges of the hand (HP:0009771)1.96692067
77Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96464942
78Gangrene (HP:0100758)1.96069242
79Epistaxis (HP:0000421)1.95768298
80Prominent nose (HP:0000448)1.94107560
81Acute myeloid leukemia (HP:0004808)1.92888799
82Slow saccadic eye movements (HP:0000514)1.87586055
83Increased CSF protein (HP:0002922)1.86816030
84Abnormality of the pleura (HP:0002103)1.86099344
85Amyloidosis (HP:0011034)1.85188805
86Ocular albinism (HP:0001107)1.82181891
87Alveolar cell carcinoma (HP:0006519)1.81451165
88Widely spaced teeth (HP:0000687)1.81356391
89Dysostosis multiplex (HP:0000943)1.80670408
90Thyroiditis (HP:0100646)1.80589632
91Keratitis (HP:0000491)1.79074283
92Coarse hair (HP:0002208)1.78649559
93Hypoplasia of the thymus (HP:0000778)1.77804400
94Amaurosis fugax (HP:0100576)1.76792626
95Myocardial infarction (HP:0001658)1.76091095
96Pulmonary embolism (HP:0002204)1.73641141
97Chronic otitis media (HP:0000389)1.67121870
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.64531867
99Conjunctival telangiectasia (HP:0000524)1.62597356
100Cerebral aneurysm (HP:0004944)1.62042071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.20443631
2RIPK42.85378195
3TYK22.76989403
4MAP3K142.52758169
5TXK2.27586782
6TAOK32.25926661
7MAP4K12.24373912
8MAP3K132.24079025
9IKBKE2.21308155
10CSK2.12225118
11CDK122.03580012
12MAP2K32.03438590
13JAK12.02138620
14MAP3K31.99714681
15FRK1.83519527
16BMPR21.79656686
17JAK31.74626449
18ZAP701.72819323
19IKBKB1.66664028
20PIK3CG1.65770519
21BRD41.64224553
22ACVR1B1.63141205
23MARK31.59852911
24FES1.58913860
25IRAK41.56272316
26PRPF4B1.47299411
27FGR1.45201359
28NLK1.42365244
29TEC1.41736499
30KIT1.39972143
31IRAK31.26774096
32GRK61.25529496
33HCK1.24995545
34BTK1.23181196
35CHUK1.22211723
36FGFR31.21865879
37CSF1R1.19467213
38TBK11.19462405
39WNK11.19096192
40SGK21.18750596
41SYK1.17328878
42MELK1.11686818
43CAMK1D1.11502943
44IRAK11.09172855
45GRK71.08661556
46LCK1.07527609
47ITK1.07314650
48PDGFRB1.06862438
49MARK21.04503520
50SGK31.03694226
51MAPK71.03198215
52TRPM71.00718919
53TGFBR20.99758050
54JAK20.99591068
55LYN0.94958603
56MAP3K10.92001498
57CAMK1G0.91796440
58SIK30.91189199
59CDC42BPA0.88124612
60MATK0.87477023
61TNK20.85270927
62AKT30.85131222
63MAP3K70.84852061
64EPHB10.81053820
65MST1R0.80598196
66NEK60.78664320
67ERBB20.78504358
68FGFR20.78471779
69STK100.73607420
70YES10.71768135
71PTK2B0.71145641
72TAOK10.71109548
73DDR20.70538360
74MAP3K20.67179861
75CDK60.62149044
76HIPK20.58580431
77PKN20.55347673
78PDK10.55152032
79PIM10.54566300
80FGFR40.54328673
81PRKCQ0.53220024
82EPHA30.52212788
83CAMKK20.50608395
84RIPK10.50098043
85STK380.48520027
86MTOR0.45624559
87KSR10.45536422
88PIK3CA0.43353613
89EGFR0.42744756
90PRKAA20.41766419
91MAP3K50.41392249
92SGK10.41096343
93CDK40.40638808
94SGK2230.40456522
95SGK4940.40456522
96ABL10.40057278
97BRSK20.39056415
98MAP3K100.37996846
99IRAK20.37303941
100MAP2K60.35203946

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.53355463
2Leishmaniasis_Homo sapiens_hsa051402.50976413
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.25324330
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12939340
5Graft-versus-host disease_Homo sapiens_hsa053322.12742247
6Staphylococcus aureus infection_Homo sapiens_hsa051502.04732608
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.00560407
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97318138
9B cell receptor signaling pathway_Homo sapiens_hsa046621.79745652
10TNF signaling pathway_Homo sapiens_hsa046681.79484144
11T cell receptor signaling pathway_Homo sapiens_hsa046601.77308319
12Allograft rejection_Homo sapiens_hsa053301.74734091
13Malaria_Homo sapiens_hsa051441.74259628
14Tuberculosis_Homo sapiens_hsa051521.71882058
15Legionellosis_Homo sapiens_hsa051341.68227146
16Dorso-ventral axis formation_Homo sapiens_hsa043201.67859230
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64445081
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62917880
19Measles_Homo sapiens_hsa051621.58021199
20Autoimmune thyroid disease_Homo sapiens_hsa053201.56510651
21Toxoplasmosis_Homo sapiens_hsa051451.54703203
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.53986016
23Influenza A_Homo sapiens_hsa051641.53019624
24Other glycan degradation_Homo sapiens_hsa005111.50220960
25Primary immunodeficiency_Homo sapiens_hsa053401.47365477
26Acute myeloid leukemia_Homo sapiens_hsa052211.45985943
27Hematopoietic cell lineage_Homo sapiens_hsa046401.42959437
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42759532
29Hepatitis B_Homo sapiens_hsa051611.33563349
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32876376
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32641836
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28151970
33Asthma_Homo sapiens_hsa053101.26958733
34Non-small cell lung cancer_Homo sapiens_hsa052231.26926807
35Chemokine signaling pathway_Homo sapiens_hsa040621.26569450
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.24912613
37Platelet activation_Homo sapiens_hsa046111.24864035
38Antigen processing and presentation_Homo sapiens_hsa046121.20770522
39Herpes simplex infection_Homo sapiens_hsa051681.20285722
40Rheumatoid arthritis_Homo sapiens_hsa053231.14529256
41Type I diabetes mellitus_Homo sapiens_hsa049401.11860784
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09269023
43African trypanosomiasis_Homo sapiens_hsa051431.08438585
44Pertussis_Homo sapiens_hsa051331.07179903
45Chronic myeloid leukemia_Homo sapiens_hsa052201.05343116
46Hepatitis C_Homo sapiens_hsa051601.04599465
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02414100
48FoxO signaling pathway_Homo sapiens_hsa040681.01540023
49Amoebiasis_Homo sapiens_hsa051461.00857264
50Prolactin signaling pathway_Homo sapiens_hsa049170.98758113
51Pancreatic cancer_Homo sapiens_hsa052120.98619058
52Viral myocarditis_Homo sapiens_hsa054160.95294908
53Prostate cancer_Homo sapiens_hsa052150.95181503
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.94250133
55Notch signaling pathway_Homo sapiens_hsa043300.93560382
56Renal cell carcinoma_Homo sapiens_hsa052110.91358744
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91348072
58Endometrial cancer_Homo sapiens_hsa052130.91236120
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90982787
60Inositol phosphate metabolism_Homo sapiens_hsa005620.90361560
61Apoptosis_Homo sapiens_hsa042100.83502369
62Choline metabolism in cancer_Homo sapiens_hsa052310.81166037
63Lysosome_Homo sapiens_hsa041420.78292051
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.75874961
65Salmonella infection_Homo sapiens_hsa051320.74998808
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.74650214
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70332683
68mTOR signaling pathway_Homo sapiens_hsa041500.69869428
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68801599
70Colorectal cancer_Homo sapiens_hsa052100.68703522
71ErbB signaling pathway_Homo sapiens_hsa040120.67794204
72Phagosome_Homo sapiens_hsa041450.67406108
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67319072
74VEGF signaling pathway_Homo sapiens_hsa043700.66770850
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64785265
76Small cell lung cancer_Homo sapiens_hsa052220.64047338
77GnRH signaling pathway_Homo sapiens_hsa049120.63816315
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.63359298
79HIF-1 signaling pathway_Homo sapiens_hsa040660.63169259
80Insulin resistance_Homo sapiens_hsa049310.59705123
81MicroRNAs in cancer_Homo sapiens_hsa052060.59328963
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58572956
83HTLV-I infection_Homo sapiens_hsa051660.57662408
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.57603790
85Epstein-Barr virus infection_Homo sapiens_hsa051690.57352716
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54594300
87Lysine degradation_Homo sapiens_hsa003100.54282482
88Shigellosis_Homo sapiens_hsa051310.53882503
89MAPK signaling pathway_Homo sapiens_hsa040100.53635238
90Glioma_Homo sapiens_hsa052140.53220375
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53014670
92Circadian rhythm_Homo sapiens_hsa047100.51507280
93Proteoglycans in cancer_Homo sapiens_hsa052050.50772970
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49523564
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.49187072
96Viral carcinogenesis_Homo sapiens_hsa052030.47852641
97ABC transporters_Homo sapiens_hsa020100.46110081
98Estrogen signaling pathway_Homo sapiens_hsa049150.45088442
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44373265
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43295499

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