ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hemidesmosome assembly (GO:0031581)	5.72876269
2	regulation of DNA endoreduplication (GO:0032875)	4.24836264
3	establishment of protein localization to Golgi (GO:0072600)	4.11740879
4	sister chromatid cohesion (GO:0007062)	4.07477809
5	protein targeting to Golgi (GO:0000042)	3.97060738
6	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.81421385
7	regulation of RNA export from nucleus (GO:0046831)	3.59700316
8	mitotic sister chromatid cohesion (GO:0007064)	3.37885450
9	protein localization to Golgi apparatus (GO:0034067)	3.32587887
10	regulation of hippo signaling (GO:0035330)	3.29053777
11	replication fork processing (GO:0031297)	3.22781230
12	microtubule anchoring (GO:0034453)	3.17137400
13	RNA localization (GO:0006403)	3.06671134
14	limb bud formation (GO:0060174)	2.92414716
15	intraciliary transport (GO:0042073)	2.91981403
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.90977356
17	negative regulation of axon guidance (GO:1902668)	2.86657442
18	histone H2A acetylation (GO:0043968)	2.86336278
19	regulation of nucleobase-containing compound transport (GO:0032239)	2.81026629
20	kinetochore organization (GO:0051383)	2.79254278
21	pericardium development (GO:0060039)	2.75632315
22	centriole replication (GO:0007099)	2.73939503
23	nuclear pore complex assembly (GO:0051292)	2.71688644
24	microtubule polymerization or depolymerization (GO:0031109)	2.70412100
25	mitotic cytokinesis (GO:0000281)	2.70404073
26	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.69124960
27	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.67790955
28	kinetochore assembly (GO:0051382)	2.63814257
29	cerebral cortex radially oriented cell migration (GO:0021799)	2.58936768
30	hindbrain development (GO:0030902)	2.55109557
31	microtubule depolymerization (GO:0007019)	2.54443138
32	regulation of hexokinase activity (GO:1903299)	2.54419049
33	regulation of glucokinase activity (GO:0033131)	2.54419049
34	DNA-dependent DNA replication (GO:0006261)	2.54371859
35	cilium morphogenesis (GO:0060271)	2.53394017
36	intra-Golgi vesicle-mediated transport (GO:0006891)	2.52865473
37	establishment of nucleus localization (GO:0040023)	2.50403212
38	cornea development in camera-type eye (GO:0061303)	2.49526845
39	negative regulation of keratinocyte proliferation (GO:0010839)	2.44023610
40	regulation of mitotic spindle organization (GO:0060236)	2.43859011
41	nucleus localization (GO:0051647)	2.43316519
42	nuclear pore organization (GO:0006999)	2.43134472
43	monoubiquitinated protein deubiquitination (GO:0035520)	2.43025059
44	snRNA transcription (GO:0009301)	2.42530403
45	cytoskeleton-dependent cytokinesis (GO:0061640)	2.39013350
46	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.38234754
47	oxidative demethylation (GO:0070989)	2.38057485
48	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.37198825
49	behavioral response to nicotine (GO:0035095)	2.36820439
50	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.34862968
51	positive regulation of meiosis (GO:0045836)	2.31452535
52	regulation of axon guidance (GO:1902667)	2.30843301
53	negative regulation of activin receptor signaling pathway (GO:0032926)	2.30193540
54	double-strand break repair via homologous recombination (GO:0000724)	2.28558050
55	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.28290589
56	substrate-independent telencephalic tangential migration (GO:0021826)	2.28290589
57	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.26966958
58	auditory receptor cell differentiation (GO:0042491)	2.26618990
59	TOR signaling (GO:0031929)	2.25427544
60	epithelial cilium movement (GO:0003351)	2.25366758
61	drug catabolic process (GO:0042737)	2.25077917
62	central nervous system neuron axonogenesis (GO:0021955)	2.24761248
63	genitalia morphogenesis (GO:0035112)	2.24403407
64	regulation of timing of cell differentiation (GO:0048505)	2.23547958
65	recombinational repair (GO:0000725)	2.23369634
66	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.23181940
67	centriole assembly (GO:0098534)	2.22964608
68	peristalsis (GO:0030432)	2.22186686
69	regulation of centriole replication (GO:0046599)	2.19656985
70	positive regulation of meiotic cell cycle (GO:0051446)	2.19647642
71	sympathetic nervous system development (GO:0048485)	2.19528511
72	intestinal cholesterol absorption (GO:0030299)	2.18929369
73	protein prenylation (GO:0018342)	2.18115642
74	prenylation (GO:0097354)	2.18115642
75	lens development in camera-type eye (GO:0002088)	2.17509285
76	photoreceptor cell development (GO:0042461)	2.17068180
77	myoblast fusion (GO:0007520)	2.14697419
78	negative regulation of systemic arterial blood pressure (GO:0003085)	2.14545098
79	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.14429634
80	regulation of translation, ncRNA-mediated (GO:0045974)	2.14429634
81	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.14429634
82	regulation of sarcomere organization (GO:0060297)	2.13604644
83	photoreceptor cell differentiation (GO:0046530)	2.13307299
84	eye photoreceptor cell differentiation (GO:0001754)	2.13307299
85	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.13013945
86	regulation of axon extension involved in axon guidance (GO:0048841)	2.12081523
87	cellular response to sterol (GO:0036315)	2.10796680
88	cilium assembly (GO:0042384)	2.10736561
89	cilium organization (GO:0044782)	2.10169772
90	indolalkylamine metabolic process (GO:0006586)	2.09468548
91	nephron tubule morphogenesis (GO:0072078)	2.09352657
92	nephron epithelium morphogenesis (GO:0072088)	2.09352657
93	cell wall macromolecule catabolic process (GO:0016998)	2.08622687
94	protein localization to cytoskeleton (GO:0044380)	2.07900353
95	myelin assembly (GO:0032288)	2.07690006
96	regulation of centrosome duplication (GO:0010824)	2.07395908
97	peripheral nervous system axon ensheathment (GO:0032292)	2.06366213
98	myelination in peripheral nervous system (GO:0022011)	2.06366213
99	cytoplasmic microtubule organization (GO:0031122)	2.06190615
100	musculoskeletal movement (GO:0050881)	2.05975130

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.85754443
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.31237942
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.87877199
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.85758959
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.49772989
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46672318
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36729738
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.34537072
9	TP53_16413492_ChIP-PET_HCT116_Human	2.14365310
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.13596888
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.11721481
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11627705
13	FUS_26573619_Chip-Seq_HEK293_Human	2.10194350
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09922342
15	EWS_26573619_Chip-Seq_HEK293_Human	2.08062181
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00690556
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.00228674
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.99176522
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97162029
20	VDR_22108803_ChIP-Seq_LS180_Human	1.96909869
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.92804591
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.88835210
23	STAT3_23295773_ChIP-Seq_U87_Human	1.86757517
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.85820359
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82803577
26	P300_19829295_ChIP-Seq_ESCs_Human	1.77513718
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75707842
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.71210152
29	* ESR1_20079471_ChIP-ChIP_T-47D_Human	1.69785972
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65149056
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.65149056
32	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.64472215
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62421873
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62158375
35	* TCF4_23295773_ChIP-Seq_U87_Human	1.59158597
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58607547
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56123613
38	TP53_18474530_ChIP-ChIP_U2OS_Human	1.49181884
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48871137
40	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.48472415
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.47271830
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46644347
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45670176
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.45054171
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.40643745
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40351688
47	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39070108
48	CJUN_26792858_Chip-Seq_BT549_Human	1.39064667
49	AR_25329375_ChIP-Seq_VCAP_Human	1.38395265
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36095595
51	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.34517477
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34495823
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33633228
54	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32293308
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31848808
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31604221
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30928958
58	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.30623546
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.28139352
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24978685
61	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.24774609
62	TBL1_22424771_ChIP-Seq_293T_Human	1.24549593
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23723655
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23462587
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22549187
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20210181
67	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.19802111
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19133924
69	BRD4_25478319_ChIP-Seq_HGPS_Human	1.18699222
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18008626
71	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.17712739
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.17611480
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17330073
74	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.16514193
75	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16139934
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15193762
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15193762
78	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.14331742
79	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.13772916
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13543697
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10444805
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.09481272
83	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07758555
84	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06571568
85	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06571568
86	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.06140830
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04897113
88	RXR_22108803_ChIP-Seq_LS180_Human	1.01803803
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01379120
90	TP53_22573176_ChIP-Seq_HFKS_Human	1.01316601
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01309307
92	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.01211082
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00524214
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.99453349
95	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99219122
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98928040
97	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97697308
98	NFYB_21822215_ChIP-Seq_K562_Human	0.97648168
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97508493
100	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.97328254

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	2.74050280
2	MP0003950_abnormal_plasma_membrane	2.63523448
3	MP0000569_abnormal_digit_pigmentation	2.32065180
4	MP0001299_abnormal_eye_distance/	2.23830345
5	MP0000751_myopathy	2.23425483
6	MP0006292_abnormal_olfactory_placode	2.06943077
7	MP0003195_calcinosis	1.95776202
8	MP0009780_abnormal_chondrocyte_physiolo	1.95372486
9	MP0002938_white_spotting	1.87678032
10	MP0002269_muscular_atrophy	1.79280917
11	MP0005257_abnormal_intraocular_pressure	1.76489959
12	MP0005187_abnormal_penis_morphology	1.74486939
13	MP0000427_abnormal_hair_cycle	1.72597050
14	MP0002234_abnormal_pharynx_morphology	1.71980560
15	MP0010030_abnormal_orbit_morphology	1.69077590
16	MP0002168_other_aberrant_phenotype	1.65980757
17	MP0002332_abnormal_exercise_endurance	1.64145486
18	MP0009046_muscle_twitch	1.60779554
19	MP0008057_abnormal_DNA_replication	1.59917830
20	MP0003937_abnormal_limbs/digits/tail_de	1.56480314
21	MP0003252_abnormal_bile_duct	1.55207172
22	MP0003755_abnormal_palate_morphology	1.52434338
23	MP0003045_fibrosis	1.51853745
24	MP0002233_abnormal_nose_morphology	1.49168716
25	MP0002928_abnormal_bile_duct	1.49019885
26	MP0003935_abnormal_craniofacial_develop	1.48790853
27	MP0005408_hypopigmentation	1.42973306
28	MP0009697_abnormal_copulation	1.40969146
29	MP0003890_abnormal_embryonic-extraembry	1.38439069
30	MP0000778_abnormal_nervous_system	1.35741359
31	MP0004043_abnormal_pH_regulation	1.35194641
32	MP0002734_abnormal_mechanical_nocicepti	1.30461573
33	MP0005551_abnormal_eye_electrophysiolog	1.29825634
34	MP0005023_abnormal_wound_healing	1.29808412
35	MP0008877_abnormal_DNA_methylation	1.29198577
36	MP0008058_abnormal_DNA_repair	1.28729032
37	MP0002638_abnormal_pupillary_reflex	1.22591396
38	MP0002837_dystrophic_cardiac_calcinosis	1.22432462
39	MP0002697_abnormal_eye_size	1.21800389
40	MP0000762_abnormal_tongue_morphology	1.17994795
41	MP0000631_abnormal_neuroendocrine_gland	1.17074909
42	MP0000647_abnormal_sebaceous_gland	1.16967236
43	MP0003943_abnormal_hepatobiliary_system	1.16703910
44	MP0003868_abnormal_feces_composition	1.16700167
45	MP0003385_abnormal_body_wall	1.16506932
46	MP0003942_abnormal_urinary_system	1.14645755
47	MP0002184_abnormal_innervation	1.13300369
48	MP0002751_abnormal_autonomic_nervous	1.12276445
49	MP0002876_abnormal_thyroid_physiology	1.09164627
50	MP0010094_abnormal_chromosome_stability	1.08571149
51	MP0009250_abnormal_appendicular_skeleto	1.07893492
52	MP0000372_irregular_coat_pigmentation	1.07072446
53	MP0005395_other_phenotype	1.06898146
54	MP0003787_abnormal_imprinting	1.06726362
55	MP0000566_synostosis	1.05696822
56	MP0005266_abnormal_metabolism	1.03280611
57	MP0002095_abnormal_skin_pigmentation	1.03254978
58	MP0002249_abnormal_larynx_morphology	1.02362666
59	MP0004142_abnormal_muscle_tone	1.01692968
60	MP0002282_abnormal_trachea_morphology	1.00323610
61	MP0000015_abnormal_ear_pigmentation	0.99896726
62	MP0002177_abnormal_outer_ear	0.99386325
63	MP0002295_abnormal_pulmonary_circulatio	0.98590434
64	MP0000383_abnormal_hair_follicle	0.97303579
65	MP0000049_abnormal_middle_ear	0.96303423
66	MP0001666_abnormal_nutrient_absorption	0.95423167
67	MP0000432_abnormal_head_morphology	0.94777769
68	MP0002160_abnormal_reproductive_system	0.93912168
69	MP0000428_abnormal_craniofacial_morphol	0.93256310
70	MP0002102_abnormal_ear_morphology	0.93224740
71	MP0004134_abnormal_chest_morphology	0.92407893
72	MP0010678_abnormal_skin_adnexa	0.92168224
73	MP0010368_abnormal_lymphatic_system	0.91958382
74	MP0008789_abnormal_olfactory_epithelium	0.91399157
75	MP0001324_abnormal_eye_pigmentation	0.90327233
76	MP0001968_abnormal_touch/_nociception	0.89659577
77	MP0001270_distended_abdomen	0.89208365
78	MP0002272_abnormal_nervous_system	0.85109895
79	MP0003121_genomic_imprinting	0.84911891
80	MP0001243_abnormal_dermal_layer	0.84876061
81	MP0002116_abnormal_craniofacial_bone	0.84525920
82	MP0002109_abnormal_limb_morphology	0.82527247
83	MP0005646_abnormal_pituitary_gland	0.81971231
84	MP0000534_abnormal_ureter_morphology	0.81728356
85	MP0008875_abnormal_xenobiotic_pharmacok	0.81013472
86	MP0005386_behavior/neurological_phenoty	0.80095388
87	MP0004924_abnormal_behavior	0.80095388
88	MP0001286_abnormal_eye_development	0.80060806
89	MP0002108_abnormal_muscle_morphology	0.79834920
90	MP0005174_abnormal_tail_pigmentation	0.79759912
91	MP0004272_abnormal_basement_membrane	0.79237585
92	MP0004270_analgesia	0.78939091
93	MP0004133_heterotaxia	0.76357628
94	MP0001486_abnormal_startle_reflex	0.75904271
95	MP0006035_abnormal_mitochondrial_morpho	0.75869230
96	MP0001929_abnormal_gametogenesis	0.74672130
97	MP0000613_abnormal_salivary_gland	0.72838975
98	MP0001984_abnormal_olfaction	0.71057022
99	MP0000579_abnormal_nail_morphology	0.70078410
100	MP0002210_abnormal_sex_determination	0.69965698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Urethral obstruction (HP:0000796)	5.98411181
2	Alopecia of scalp (HP:0002293)	4.85483244
3	Volvulus (HP:0002580)	4.82278606
4	Neonatal respiratory distress (HP:0002643)	4.43971385
5	Abnormality of the neuromuscular junction (HP:0003398)	3.47347602
6	Fatigable weakness (HP:0003473)	3.47347602
7	Hyperventilation (HP:0002883)	3.16054043
8	Milia (HP:0001056)	3.12191978
9	Thick nail (HP:0001805)	2.94778892
10	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.85336153
11	Short 1st metacarpal (HP:0010034)	2.85336153
12	Hypoplastic ischia (HP:0003175)	2.80702268
13	Abnormality of midbrain morphology (HP:0002418)	2.74599172
14	Molar tooth sign on MRI (HP:0002419)	2.74599172
15	Short chin (HP:0000331)	2.72283545
16	Abnormality of the lower motor neuron (HP:0002366)	2.63823130
17	Abnormality of the ischium (HP:0003174)	2.57519109
18	Pancreatic cysts (HP:0001737)	2.54151787
19	Fragile skin (HP:0001030)	2.53059867
20	Limited hip movement (HP:0008800)	2.52109612
21	Chromsome breakage (HP:0040012)	2.47639174
22	Oligomenorrhea (HP:0000876)	2.47332066
23	Abnormality of the 1st metacarpal (HP:0010009)	2.44066443
24	Abnormality of the renal cortex (HP:0011035)	2.41987646
25	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39606264
26	Pancreatic fibrosis (HP:0100732)	2.36415697
27	Oligodontia (HP:0000677)	2.32099259
28	Microtia (HP:0008551)	2.31532357
29	Ectopic kidney (HP:0000086)	2.29600722
30	Broad-based gait (HP:0002136)	2.26655803
31	Nephronophthisis (HP:0000090)	2.25323559
32	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.24611409
33	Increased connective tissue (HP:0009025)	2.23906306
34	Small hand (HP:0200055)	2.23895518
35	True hermaphroditism (HP:0010459)	2.18767508
36	Decreased lacrimation (HP:0000633)	2.18714571
37	Alacrima (HP:0000522)	2.17039859
38	Tubulointerstitial nephritis (HP:0001970)	2.16502966
39	Abnormality of the renal medulla (HP:0100957)	2.16457351
40	Long clavicles (HP:0000890)	2.15446484
41	Renal cortical cysts (HP:0000803)	2.15197595
42	Gaze-evoked nystagmus (HP:0000640)	2.13933841
43	Bifid tongue (HP:0010297)	2.09141918
44	Difficulty climbing stairs (HP:0003551)	2.08678734
45	Intestinal atresia (HP:0011100)	2.03679329
46	Short phalanx of the thumb (HP:0009660)	2.00866028
47	Heterotopia (HP:0002282)	1.99310181
48	Abnormality of the carotid arteries (HP:0005344)	1.98586826
49	Type II lissencephaly (HP:0007260)	1.98405491
50	Abnormality of the nasal septum (HP:0000419)	1.97183053
51	Tubular atrophy (HP:0000092)	1.97161305
52	Abnormality of chromosome stability (HP:0003220)	1.97101463
53	Cerebellar dysplasia (HP:0007033)	1.96656739
54	Abnormality of the preputium (HP:0100587)	1.95940681
55	Abnormality of the astrocytes (HP:0100707)	1.94374086
56	Astrocytoma (HP:0009592)	1.94374086
57	Increased number of teeth (HP:0011069)	1.93526820
58	Abnormality of the ileum (HP:0001549)	1.93185794
59	Neoplasm of the oral cavity (HP:0100649)	1.92636784
60	Gowers sign (HP:0003391)	1.90979474
61	Meckel diverticulum (HP:0002245)	1.89865042
62	Popliteal pterygium (HP:0009756)	1.83175036
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81900634
64	Low anterior hairline (HP:0000294)	1.81743637
65	Glioma (HP:0009733)	1.80732066
66	Truncal obesity (HP:0001956)	1.80648782
67	Chronic hepatic failure (HP:0100626)	1.80324231
68	Widely spaced teeth (HP:0000687)	1.79861871
69	Increased nuchal translucency (HP:0010880)	1.79271980
70	Cystic liver disease (HP:0006706)	1.79257302
71	Weak cry (HP:0001612)	1.78928635
72	Muscular dystrophy (HP:0003560)	1.78371127
73	Depressed nasal tip (HP:0000437)	1.75832153
74	Abnormality of the phalanges of the hallux (HP:0010057)	1.75408258
75	Fair hair (HP:0002286)	1.75125810
76	Clubbing of toes (HP:0100760)	1.75030229
77	Hand muscle atrophy (HP:0009130)	1.72103983
78	Sloping forehead (HP:0000340)	1.71206027
79	Preaxial foot polydactyly (HP:0001841)	1.70347722
80	Overlapping toe (HP:0001845)	1.68394933
81	Hypoplastic labia majora (HP:0000059)	1.67772827
82	Smooth philtrum (HP:0000319)	1.67081210
83	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.66476011
84	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.63609853
85	Tubulointerstitial abnormality (HP:0001969)	1.62661767
86	Limited elbow extension (HP:0001377)	1.62457552
87	Abnormality of the labia majora (HP:0012881)	1.62146699
88	Highly arched eyebrow (HP:0002553)	1.61743991
89	Long nose (HP:0003189)	1.61285423
90	Atrophic scars (HP:0001075)	1.60076497
91	Hypoplastic iliac wings (HP:0002866)	1.59815816
92	Increased corneal curvature (HP:0100692)	1.59242113
93	Keratoconus (HP:0000563)	1.59242113
94	Gastrointestinal atresia (HP:0002589)	1.58957453
95	Short thumb (HP:0009778)	1.58611361
96	Distal upper limb amyotrophy (HP:0007149)	1.58565433
97	Upper limb amyotrophy (HP:0009129)	1.58565433
98	Underdeveloped nasal alae (HP:0000430)	1.57988020
99	Attenuation of retinal blood vessels (HP:0007843)	1.57906693
100	Exotropia (HP:0000577)	1.56127706

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.58560794
2	PNCK	3.48935180
3	CASK	3.23681594
4	MST1R	3.13719851
5	WNK4	2.28860769
6	BMPR1B	2.11480179
7	MAP3K9	2.02049078
8	MET	1.96773279
9	FGFR2	1.88851334
10	LATS1	1.87747563
11	NTRK3	1.80594098
12	MAP3K12	1.80227080
13	MAP4K2	1.80178692
14	BRSK2	1.73273838
15	STK39	1.72399434
16	MAP3K4	1.69736670
17	EIF2AK3	1.68308927
18	NUAK1	1.54706981
19	EPHA4	1.53938004
20	WNK3	1.53270483
21	CDK3	1.53075347
22	TNIK	1.51375154
23	BCR	1.44011023
24	PAK3	1.38757272
25	WEE1	1.38717049
26	MUSK	1.34418428
27	EIF2AK1	1.31944883
28	CAMK1G	1.27915611
29	SIK2	1.27121622
30	MAPK13	1.26500726
31	NEK2	1.24769693
32	OXSR1	1.18089855
33	CDK12	1.11839659
34	WNK1	1.11242115
35	EPHA3	1.08923556
36	MKNK2	1.04620692
37	TRPM7	1.00987016
38	GRK1	0.97476899
39	PTK2	0.97366144
40	PLK1	0.96971736
41	MARK1	0.95996728
42	PRKCE	0.93371913
43	STK3	0.93091724
44	AKT3	0.92345902
45	INSRR	0.92187245
46	PLK2	0.91733567
47	ACVR1B	0.89792180
48	MST4	0.88791152
49	TRIM28	0.86906497
50	PTK2B	0.86461896
51	TAOK3	0.85960776
52	STK38	0.85895399
53	STK38L	0.85334966
54	ATM	0.79972141
55	SGK2	0.78478238
56	PDGFRB	0.77601283
57	PBK	0.76731350
58	CCNB1	0.76508897
59	PKN1	0.76480536
60	ZAK	0.73136914
61	ROCK1	0.68898063
62	MTOR	0.68062675
63	AURKB	0.68058847
64	PLK4	0.67318621
65	NME1	0.64075402
66	PRKACB	0.61751505
67	FER	0.61501669
68	DMPK	0.58879653
69	SGK1	0.58856944
70	CHEK1	0.58242469
71	CSNK1E	0.57681872
72	PRKDC	0.56249247
73	ADRBK1	0.55981274
74	ADRBK2	0.54279074
75	TGFBR2	0.53572919
76	MELK	0.51743312
77	CAMK2A	0.51535547
78	PINK1	0.51329213
79	MAPK14	0.49905780
80	CHEK2	0.49753904
81	BRSK1	0.49649922
82	ATR	0.48072744
83	CDC42BPA	0.47575731
84	CDK1	0.47408938
85	FGFR1	0.45514548
86	NTRK2	0.45170849
87	CDK8	0.44742390
88	TSSK6	0.44523908
89	CAMK2D	0.43979817
90	PIK3CA	0.43602291
91	CAMK2B	0.42802180
92	PRKG1	0.42296312
93	BRD4	0.42065141
94	KSR1	0.42005221
95	PHKG1	0.39051632
96	PHKG2	0.39051632
97	MAP2K1	0.37731724
98	BUB1	0.37263218
99	CSNK1D	0.37101886
100	MAP2K6	0.36678059

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61179969
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.18778312
3	Basal transcription factors_Homo sapiens_hsa03022	2.11648223
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.09319389
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07265652
6	Non-homologous end-joining_Homo sapiens_hsa03450	1.95096085
7	Lysine degradation_Homo sapiens_hsa00310	1.94778789
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.93570191
9	Butanoate metabolism_Homo sapiens_hsa00650	1.88251542
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82987578
11	Homologous recombination_Homo sapiens_hsa03440	1.80858869
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.71078100
13	Protein export_Homo sapiens_hsa03060	1.68089679
14	ABC transporters_Homo sapiens_hsa02010	1.67840121
15	RNA polymerase_Homo sapiens_hsa03020	1.66243029
16	Caffeine metabolism_Homo sapiens_hsa00232	1.62212162
17	Taste transduction_Homo sapiens_hsa04742	1.60631683
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.59493800
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.53422965
20	Propanoate metabolism_Homo sapiens_hsa00640	1.53341722
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52019413
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50962442
23	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.48009613
24	Retinol metabolism_Homo sapiens_hsa00830	1.43361513
25	Complement and coagulation cascades_Homo sapiens_hsa04610	1.43000894
26	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.42567823
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.42438392
28	Nicotine addiction_Homo sapiens_hsa05033	1.32141757
29	Phototransduction_Homo sapiens_hsa04744	1.28164159
30	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.22861246
31	Insulin secretion_Homo sapiens_hsa04911	1.20519885
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.20096684
33	RNA transport_Homo sapiens_hsa03013	1.18667008
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18335081
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.16647959
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14872092
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.14526460
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.13881456
39	RNA degradation_Homo sapiens_hsa03018	1.13871935
40	Circadian rhythm_Homo sapiens_hsa04710	1.10009601
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08351767
42	Olfactory transduction_Homo sapiens_hsa04740	1.07627213
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.06896370
44	Oocyte meiosis_Homo sapiens_hsa04114	1.02967441
45	Axon guidance_Homo sapiens_hsa04360	1.00242623
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.97609622
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97294772
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.93569461
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93302422
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91703506
51	Mineral absorption_Homo sapiens_hsa04978	0.90320149
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.89780530
53	Bile secretion_Homo sapiens_hsa04976	0.88064152
54	ECM-receptor interaction_Homo sapiens_hsa04512	0.88050473
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.86157971
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.84892734
57	One carbon pool by folate_Homo sapiens_hsa00670	0.84404277
58	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82817983
59	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.82496963
60	Folate biosynthesis_Homo sapiens_hsa00790	0.82411816
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.81650228
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.79221668
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77260867
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.77114277
65	Mismatch repair_Homo sapiens_hsa03430	0.76586133
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75255811
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.74592667
68	Salivary secretion_Homo sapiens_hsa04970	0.74559815
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73853384
70	Circadian entrainment_Homo sapiens_hsa04713	0.72266689
71	Regulation of autophagy_Homo sapiens_hsa04140	0.68596606
72	Adherens junction_Homo sapiens_hsa04520	0.67675551
73	Cocaine addiction_Homo sapiens_hsa05030	0.65709244
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64929480
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63886651
76	Sulfur metabolism_Homo sapiens_hsa00920	0.61907857
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59368430
78	Serotonergic synapse_Homo sapiens_hsa04726	0.59354416
79	Tight junction_Homo sapiens_hsa04530	0.59266021
80	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.59176011
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.58745622
82	Spliceosome_Homo sapiens_hsa03040	0.58128279
83	Peroxisome_Homo sapiens_hsa04146	0.58040526
84	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54945702
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54940172
86	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54484239
87	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53836452
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52370568
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52147490
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.51870429
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51720502
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51445033
93	Purine metabolism_Homo sapiens_hsa00230	0.48037976
94	Focal adhesion_Homo sapiens_hsa04510	0.47622103
95	Protein digestion and absorption_Homo sapiens_hsa04974	0.47020740
96	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.46033652
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44877145
98	Cell cycle_Homo sapiens_hsa04110	0.44782895
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44256770
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44103380

NBPF20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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