NBPF26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.01310911
2cellular extravasation (GO:0045123)4.65147244
3detection of molecule of bacterial origin (GO:0032490)4.61324137
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47174342
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.47174342
6modulation by symbiont of host immune response (GO:0052553)4.47174342
7positive regulation by symbiont of host defense response (GO:0052509)4.47174342
8modulation by symbiont of host defense response (GO:0052031)4.47174342
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47174342
10response to peptidoglycan (GO:0032494)4.31727162
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.08310102
12negative regulation of cell killing (GO:0031342)3.98554103
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98554103
14response to muramyl dipeptide (GO:0032495)3.98014891
15leukocyte aggregation (GO:0070486)3.84566255
16macrophage activation involved in immune response (GO:0002281)3.84433303
17regulation of gamma-delta T cell activation (GO:0046643)3.84269457
18neutrophil mediated immunity (GO:0002446)3.82130755
19negative thymic T cell selection (GO:0045060)3.73237981
20detection of other organism (GO:0098543)3.73011212
21regulation of B cell receptor signaling pathway (GO:0050855)3.64301042
22negative T cell selection (GO:0043383)3.56349440
23detection of external biotic stimulus (GO:0098581)3.55767042
24negative regulation of interleukin-12 production (GO:0032695)3.52830217
25histone H3-K4 trimethylation (GO:0080182)3.46987642
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44509456
27detection of biotic stimulus (GO:0009595)3.43084243
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35748190
29regulation of interferon-beta biosynthetic process (GO:0045357)3.26489787
30macrophage activation (GO:0042116)3.23045780
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22660675
32negative regulation of T cell mediated immunity (GO:0002710)3.22657651
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22161797
34antigen processing and presentation of endogenous antigen (GO:0019883)3.21281509
35microglial cell activation (GO:0001774)3.20502202
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19107685
37response to host (GO:0075136)3.19107685
38response to host defenses (GO:0052200)3.19107685
39detection of bacterium (GO:0016045)3.18918162
40regulation of gamma-delta T cell differentiation (GO:0045586)3.17779212
41response to interleukin-15 (GO:0070672)3.16212658
42maintenance of gastrointestinal epithelium (GO:0030277)3.15181955
43neutrophil activation involved in immune response (GO:0002283)3.14186642
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.13928963
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.13735390
46retrograde transport, vesicle recycling within Golgi (GO:0000301)3.09599578
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08755895
48peptidyl-lysine trimethylation (GO:0018023)3.07634837
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07248698
50neutrophil activation (GO:0042119)3.07185231
51cellular response to interleukin-15 (GO:0071350)3.04931055
52establishment of protein localization to Golgi (GO:0072600)3.04651037
53myeloid leukocyte mediated immunity (GO:0002444)2.98830610
54germinal center formation (GO:0002467)2.98774813
55protein targeting to Golgi (GO:0000042)2.98711203
56negative regulation of T-helper cell differentiation (GO:0045623)2.97696494
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97696494
58response to host immune response (GO:0052572)2.95518728
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95518728
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.95345848
61interferon-gamma production (GO:0032609)2.92657180
62regulation of mast cell degranulation (GO:0043304)2.87762675
63regulation of mast cell activation (GO:0033003)2.87520799
64dendritic cell migration (GO:0036336)2.87289312
65negative regulation of alpha-beta T cell differentiation (GO:0046639)2.84147514
66regulation of mast cell activation involved in immune response (GO:0033006)2.82897166
67myeloid cell activation involved in immune response (GO:0002275)2.81996455
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80734712
69cellular response to ethanol (GO:0071361)2.78839382
70positive regulation of granulocyte differentiation (GO:0030854)2.76208512
71granulocyte activation (GO:0036230)2.75418187
72negative regulation of interleukin-6 production (GO:0032715)2.74004827
73regulation of B cell differentiation (GO:0045577)2.71543882
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69004030
75negative regulation of alpha-beta T cell activation (GO:0046636)2.68471186
76regulation of fibroblast apoptotic process (GO:2000269)2.68329758
77T cell selection (GO:0045058)2.67281675
78phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66717815
79interleukin-6-mediated signaling pathway (GO:0070102)2.65838737
80leukocyte migration involved in inflammatory response (GO:0002523)2.65329861
81negative regulation of leukocyte mediated immunity (GO:0002704)2.65060441
82activated T cell proliferation (GO:0050798)2.61694347
83regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61106513
84regulation of MHC class I biosynthetic process (GO:0045343)2.57861449
85positive regulation of cellular amide metabolic process (GO:0034250)2.57005061
86regulation of T-helper 2 cell differentiation (GO:0045628)2.56108272
87positive regulation of interleukin-1 beta secretion (GO:0050718)2.53255893
88production of molecular mediator involved in inflammatory response (GO:0002532)2.51855240
89positive regulation of mast cell activation (GO:0033005)2.51705715
90negative regulation of adaptive immune response (GO:0002820)2.50808959
91positive regulation of tolerance induction (GO:0002645)2.49858609
92histone H3-K9 demethylation (GO:0033169)2.48827700
93histone demethylation (GO:0016577)2.47119442
94histone H3-K36 demethylation (GO:0070544)2.45702074
95histone H3-K9 modification (GO:0061647)2.45016714
96hepatocyte apoptotic process (GO:0097284)2.44377087
97dendritic cell chemotaxis (GO:0002407)2.44176162
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.43909444
99T cell migration (GO:0072678)2.43826565
100tolerance induction (GO:0002507)2.43568097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73630396
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95320594
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.84499262
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.41546762
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.25747048
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.19100301
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.03102947
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75594923
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.55894025
10RUNX_20019798_ChIP-Seq_JUKART_Human2.55668207
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33230100
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30392540
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.26571242
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24848718
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18214005
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15407904
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01776817
18VDR_24787735_ChIP-Seq_THP-1_Human1.99127302
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.94798715
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94113268
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93545109
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92962776
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88989499
24SPI1_23127762_ChIP-Seq_K562_Human1.82365067
25MYB_26560356_Chip-Seq_TH2_Human1.81057027
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79814096
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79653244
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74256335
29TP53_16413492_ChIP-PET_HCT116_Human1.61635821
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60400775
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59555242
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.57708499
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.55959752
34MYB_26560356_Chip-Seq_TH1_Human1.53543741
35SCL_19346495_ChIP-Seq_HPC-7_Human1.53390049
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52990369
37SPI1_23547873_ChIP-Seq_NB4_Human1.52220311
38ER_23166858_ChIP-Seq_MCF-7_Human1.50959733
39AHR_22903824_ChIP-Seq_MCF-7_Human1.49951997
40GBX2_23144817_ChIP-Seq_PC3_Human1.49419603
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48704125
42GATA1_22025678_ChIP-Seq_K562_Human1.45887011
43GATA3_26560356_Chip-Seq_TH2_Human1.39080363
44GATA3_27048872_Chip-Seq_THYMUS_Human1.37369902
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37272400
46CJUN_26792858_Chip-Seq_BT549_Human1.33516269
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28767256
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.25839241
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25511085
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17788920
51VDR_24763502_ChIP-Seq_THP-1_Human1.17733780
52BRD4_25478319_ChIP-Seq_HGPS_Human1.16958012
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13934484
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13302334
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12681663
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12681663
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12277972
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12240942
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10060911
60BCAT_22108803_ChIP-Seq_LS180_Human1.08538146
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08137840
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.07716085
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06974171
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06963788
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05735802
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.03811741
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03337321
68RXR_22108803_ChIP-Seq_LS180_Human1.03241320
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02803556
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02676922
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01585262
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01585262
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00905718
74PU_27001747_Chip-Seq_BMDM_Mouse1.00655373
75MAF_26560356_Chip-Seq_TH1_Human1.00425970
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99158279
77UTX_26944678_Chip-Seq_JUKART_Human0.97166868
78TP63_23658742_ChIP-Seq_EP156T_Human0.94545195
79AR_21572438_ChIP-Seq_LNCaP_Human0.94405660
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94062718
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94009701
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.93178869
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92904993
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92904993
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92772771
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91788337
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90927421
88STAT3_23295773_ChIP-Seq_U87_Human0.90845968
89SMAD4_21799915_ChIP-Seq_A2780_Human0.90770312
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88952101
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.88935051
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88676684
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87625892
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.86971018
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84529488
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82535507
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.79812985
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79792459
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.78963093
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78714938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.85502920
2MP0000569_abnormal_digit_pigmentation3.23682597
3MP0003436_decreased_susceptibility_to3.14113291
4MP0001835_abnormal_antigen_presentation2.89224182
5MP0000465_gastrointestinal_hemorrhage2.63398723
6MP0003763_abnormal_thymus_physiology2.47570977
7MP0004381_abnormal_hair_follicle2.40456032
8MP0003828_pulmonary_edema2.38086441
9MP0002419_abnormal_innate_immunity2.31070149
10MP0003303_peritoneal_inflammation2.30966338
11MP0001800_abnormal_humoral_immune2.19059003
12MP0000383_abnormal_hair_follicle2.00631199
13MP0000685_abnormal_immune_system1.96287851
14MP0005000_abnormal_immune_tolerance1.92066601
15MP0002723_abnormal_immune_serum1.90604304
16MP0002452_abnormal_antigen_presenting1.88085503
17MP0003300_gastrointestinal_ulcer1.86793511
18MP0005451_abnormal_body_composition1.86446494
19MP0004947_skin_inflammation1.86135387
20MP0000566_synostosis1.85118878
21MP0005025_abnormal_response_to1.83296536
22MP0005248_abnormal_Harderian_gland1.81604168
23MP0004883_abnormal_blood_vessel1.80270665
24MP0002420_abnormal_adaptive_immunity1.77251537
25MP0005164_abnormal_response_to1.76680629
26MP0002396_abnormal_hematopoietic_system1.76226249
27MP0005275_abnormal_skin_tensile1.74945988
28MP0001819_abnormal_immune_cell1.74261199
29MP0009785_altered_susceptibility_to1.73210003
30MP0009278_abnormal_bone_marrow1.71998113
31MP0003091_abnormal_cell_migration1.71457395
32MP0001533_abnormal_skeleton_physiology1.70647581
33MP0008004_abnormal_stomach_pH1.66705537
34MP0005310_abnormal_salivary_gland1.60777954
35MP0005671_abnormal_response_to1.56873280
36MP0002405_respiratory_system_inflammati1.56627033
37MP0010155_abnormal_intestine_physiology1.54786825
38MP0010678_abnormal_skin_adnexa1.54725605
39MP0001851_eye_inflammation1.53406528
40MP0006082_CNS_inflammation1.49666114
41MP0005076_abnormal_cell_differentiation1.49545167
42MP0005387_immune_system_phenotype1.48984955
43MP0001790_abnormal_immune_system1.48984955
44MP0002148_abnormal_hypersensitivity_rea1.48393999
45MP0000579_abnormal_nail_morphology1.46346432
46MP0002132_abnormal_respiratory_system1.44110105
47MP0005397_hematopoietic_system_phenotyp1.43934962
48MP0001545_abnormal_hematopoietic_system1.43934962
49MP0005408_hypopigmentation1.41905442
50MP0002009_preneoplasia1.37207771
51MP0002398_abnormal_bone_marrow1.36386117
52MP0008438_abnormal_cutaneous_collagen1.33487281
53MP0000015_abnormal_ear_pigmentation1.32725737
54MP0008260_abnormal_autophagy1.32422495
55MP0000703_abnormal_thymus_morphology1.31441034
56MP0000716_abnormal_immune_system1.31284912
57MP0003866_abnormal_defecation1.31009411
58MP0002166_altered_tumor_susceptibility1.30386017
59MP0006054_spinal_hemorrhage1.29512152
60MP0002998_abnormal_bone_remodeling1.27727371
61MP0009764_decreased_sensitivity_to1.25078219
62MP0003045_fibrosis1.23235404
63MP0002722_abnormal_immune_system1.20333574
64MP0001853_heart_inflammation1.20156684
65MP0008057_abnormal_DNA_replication1.18521834
66MP0003252_abnormal_bile_duct1.16888910
67MP0003183_abnormal_peptide_metabolism1.14832371
68MP0000427_abnormal_hair_cycle1.13766117
69MP0002168_other_aberrant_phenotype1.12412036
70MP0001845_abnormal_inflammatory_respons1.12137059
71MP0004808_abnormal_hematopoietic_stem1.08472136
72MP0003172_abnormal_lysosome_physiology1.08082327
73MP0003191_abnormal_cellular_cholesterol1.08035467
74MP0002098_abnormal_vibrissa_morphology1.07944404
75MP0000689_abnormal_spleen_morphology1.07835809
76MP0005390_skeleton_phenotype1.05263873
77MP0001958_emphysema1.04501961
78MP0005171_absent_coat_pigmentation1.02480133
79MP0010030_abnormal_orbit_morphology1.01516626
80MP0002006_tumorigenesis0.99804475
81MP0000371_diluted_coat_color0.98141228
82MP0002928_abnormal_bile_duct0.98101641
83MP0003656_abnormal_erythrocyte_physiolo0.98089190
84MP0005464_abnormal_platelet_physiology0.97308946
85MP0003705_abnormal_hypodermis_morpholog0.96806208
86MP0003950_abnormal_plasma_membrane0.94287111
87MP0008469_abnormal_protein_level0.92665136
88MP0002429_abnormal_blood_cell0.90150284
89MP0004264_abnormal_extraembryonic_tissu0.88385033
90MP0005174_abnormal_tail_pigmentation0.87104421
91MP0000372_irregular_coat_pigmentation0.86686195
92MP0003566_abnormal_cell_adhesion0.81082187
93MP0000858_altered_metastatic_potential0.80426133
94MP0008961_abnormal_basal_metabolism0.79066821
95MP0002060_abnormal_skin_morphology0.77572827
96MP0003279_aneurysm0.77038215
97MP0003795_abnormal_bone_structure0.76310987
98MP0003448_altered_tumor_morphology0.74481842
99MP0002933_joint_inflammation0.74038748
100MP0002133_abnormal_respiratory_system0.73831098

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.45834923
2Optic neuritis (HP:0100653)4.45834923
3Orchitis (HP:0100796)4.32778693
4Myositis (HP:0100614)4.21975863
5Eczematoid dermatitis (HP:0000976)4.12579454
6Absent frontal sinuses (HP:0002688)3.87304868
7Recurrent bacterial skin infections (HP:0005406)3.78517569
8Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.51598693
9Recurrent abscess formation (HP:0002722)3.51071707
10Spondylolisthesis (HP:0003302)3.28289053
11Elevated erythrocyte sedimentation rate (HP:0003565)3.24349929
12Abnormality of incisor morphology (HP:0011063)3.21857973
13Peritonitis (HP:0002586)3.20554968
14Stomatitis (HP:0010280)3.19024692
15Keratoconjunctivitis sicca (HP:0001097)3.16892434
16Stomach cancer (HP:0012126)2.98927757
17Recurrent fungal infections (HP:0002841)2.96670829
18Keratoconjunctivitis (HP:0001096)2.91419653
19Recurrent gram-negative bacterial infections (HP:0005420)2.79156228
20Abnormality of the frontal sinuses (HP:0002687)2.75374045
21Recurrent cutaneous fungal infections (HP:0011370)2.71661809
22Chronic mucocutaneous candidiasis (HP:0002728)2.71661809
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.70694082
24Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.66679580
25Recurrent skin infections (HP:0001581)2.62094681
26Abnormality of macrophages (HP:0004311)2.61231195
27T lymphocytopenia (HP:0005403)2.60106846
28Gastrointestinal infarctions (HP:0005244)2.58686066
29Subacute progressive viral hepatitis (HP:0006572)2.56853298
30Abnormality of the fingertips (HP:0001211)2.55113467
31Abnormality of T cell number (HP:0011839)2.53467553
32Pustule (HP:0200039)2.48856327
33Aortic dissection (HP:0002647)2.45542727
34Leukocytosis (HP:0001974)2.42736335
35Spinal cord lesions (HP:0100561)2.28820834
36Syringomyelia (HP:0003396)2.28820834
37Dislocated radial head (HP:0003083)2.26725726
38Increased IgE level (HP:0003212)2.26269755
39Gingivitis (HP:0000230)2.26005099
40Granulocytopenia (HP:0001913)2.25671011
41Aortic aneurysm (HP:0004942)2.25410538
42Pulmonary infiltrates (HP:0002113)2.24768267
43Eosinophilia (HP:0001880)2.22456624
44Mediastinal lymphadenopathy (HP:0100721)2.21553696
45Long eyelashes (HP:0000527)2.20321978
46Arterial tortuosity (HP:0005116)2.20025235
47Periodontitis (HP:0000704)2.19054919
48Narrow palate (HP:0000189)2.18177657
49Hemoptysis (HP:0002105)2.16187689
50Prolonged bleeding time (HP:0003010)2.15790273
51Hypoplastic ischia (HP:0003175)2.11704196
52Encephalitis (HP:0002383)2.08078380
53Abnormality of the radial head (HP:0003995)2.06744264
54Vasculitis (HP:0002633)2.06249863
55Arterial thrombosis (HP:0004420)2.05455053
56Chest pain (HP:0100749)1.96974343
57Tented upper lip vermilion (HP:0010804)1.96123872
58Abnormality of the columella (HP:0009929)1.94648842
59Pulmonary artery stenosis (HP:0004415)1.94164528
60Viral hepatitis (HP:0006562)1.93417331
61Panhypogammaglobulinemia (HP:0003139)1.93386645
62Keratitis (HP:0000491)1.92468860
63Neoplasm of the tracheobronchial system (HP:0100552)1.92122493
64Meningitis (HP:0001287)1.90353526
65Gangrene (HP:0100758)1.89987232
66Short nail (HP:0001799)1.88765396
67Thick nail (HP:0001805)1.88682067
68Abnormality of T cells (HP:0002843)1.87531642
69Recurrent viral infections (HP:0004429)1.86978520
70Vascular tortuosity (HP:0004948)1.85979559
71Toxemia of pregnancy (HP:0100603)1.85970216
72Widely spaced teeth (HP:0000687)1.85554188
73Gingival bleeding (HP:0000225)1.84344952
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83009648
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82911030
76Short 4th metacarpal (HP:0010044)1.82911030
77Abnormality of eosinophils (HP:0001879)1.82106263
78Follicular hyperkeratosis (HP:0007502)1.80663418
79Facial hemangioma (HP:0000329)1.80394836
80Bilateral sensorineural hearing impairment (HP:0008619)1.79841151
81Heterotopia (HP:0002282)1.79628934
82Abnormality of the ischium (HP:0003174)1.78331326
83Hypochromic microcytic anemia (HP:0004840)1.77884190
84Cerebral aneurysm (HP:0004944)1.77433160
85Dilatation of the ascending aorta (HP:0005111)1.76080292
86Abnormality of the peritoneum (HP:0002585)1.75706690
87Abnormality of the pleura (HP:0002103)1.74691613
88Micronodular cirrhosis (HP:0001413)1.73720970
89Difficulty running (HP:0009046)1.72625762
90Low anterior hairline (HP:0000294)1.71516900
91Coarse hair (HP:0002208)1.70718898
92Mitral valve prolapse (HP:0001634)1.69091868
93Spontaneous hematomas (HP:0007420)1.67373013
94Mitral stenosis (HP:0001718)1.63793622
95Abnormality of the endocardium (HP:0004306)1.62384077
96Alveolar cell carcinoma (HP:0006519)1.62314773
97Autoimmune hemolytic anemia (HP:0001890)1.61816946
98Depressed nasal tip (HP:0000437)1.60676354
99Prominent nose (HP:0000448)1.60247328
100Ectropion (HP:0000656)1.60062326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.13481617
2CDK123.06555769
3MAP2K32.52604248
4TXK2.31542646
5TYK22.31218473
6IRAK42.31124117
7BRD42.28755765
8MARK32.24562041
9CSK2.07838227
10ZAP702.06527044
11TAOK32.02267656
12IRAK11.99796806
13MAP3K141.95514303
14IKBKE1.91326983
15RIPK41.83908794
16MAP4K11.78252429
17EPHB11.77783987
18FES1.66076902
19TNK21.63639271
20JAK11.63345106
21EPHA31.56017611
22MAP3K31.54078144
23BMPR21.53514594
24JAK31.49815058
25MST1R1.42301691
26HCK1.36473100
27WNK11.36052497
28YES11.33075040
29NLK1.31443655
30BTK1.31127401
31IRAK21.30268795
32FGR1.29722119
33PRPF4B1.28464237
34TGFBR21.26147996
35MAP3K71.25278408
36TEC1.22574167
37IKBKB1.21789799
38MAP3K61.21431279
39JAK21.20936818
40MAP3K21.20445841
41SGK21.20240159
42PIK3CG1.17508576
43GRK61.15215510
44FGFR31.14879702
45FGFR21.11660395
46PDGFRB1.09827109
47FRK1.06531675
48TBK11.04683167
49ITK1.03881878
50MELK1.03515800
51ERBB21.03233262
52CHUK1.01600338
53SIK31.00026510
54SYK0.98244852
55MAPK70.95968515
56STK100.94588921
57LCK0.94351613
58LATS10.93346697
59SGK30.89332900
60LYN0.89231685
61TRPM70.88128518
62MAP3K130.86056770
63MARK20.85180672
64MAP3K10.82084962
65RET0.79564987
66PRKD20.73857954
67NEK60.72706706
68CSF1R0.71509225
69PTK2B0.71363138
70FGFR40.68033420
71KIT0.67385581
72CAMK1G0.66680076
73RAF10.65444844
74AKT30.63193414
75KSR10.62704672
76MAPKAPK20.60691207
77PRKCQ0.59428604
78PIK3CA0.54574830
79CDK90.53491310
80TAOK10.53148820
81NUAK10.52684077
82CDC42BPA0.52601078
83ABL10.51037212
84MTOR0.48913489
85CLK10.48124857
86MATK0.46573237
87PAK30.44962766
88PDK10.43906518
89HIPK20.42524611
90SGK4940.41575803
91SGK2230.41575803
92FER0.41260514
93ERN10.41203203
94RPS6KC10.39257779
95RPS6KL10.39257779
96KSR20.38596354
97EGFR0.38196160
98MAP3K50.38037365
99LRRK20.37691545
100CAMK1D0.37265495

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.42041083
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32947698
3Dorso-ventral axis formation_Homo sapiens_hsa043202.11736988
4Leishmaniasis_Homo sapiens_hsa051402.10948781
5Malaria_Homo sapiens_hsa051441.88949798
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.73634008
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71125941
8TNF signaling pathway_Homo sapiens_hsa046681.70425012
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69994260
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67417290
11Measles_Homo sapiens_hsa051621.63641584
12T cell receptor signaling pathway_Homo sapiens_hsa046601.61886244
13Staphylococcus aureus infection_Homo sapiens_hsa051501.60569406
14Tuberculosis_Homo sapiens_hsa051521.54734295
15B cell receptor signaling pathway_Homo sapiens_hsa046621.53155436
16Acute myeloid leukemia_Homo sapiens_hsa052211.51171790
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50603486
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.49256253
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49108892
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48210187
21Legionellosis_Homo sapiens_hsa051341.44921826
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44703932
23Hepatitis B_Homo sapiens_hsa051611.41261644
24Toxoplasmosis_Homo sapiens_hsa051451.37335966
25Non-small cell lung cancer_Homo sapiens_hsa052231.36207479
26Platelet activation_Homo sapiens_hsa046111.33940819
27Chronic myeloid leukemia_Homo sapiens_hsa052201.33327795
28Influenza A_Homo sapiens_hsa051641.32499104
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28266417
30Notch signaling pathway_Homo sapiens_hsa043301.24662414
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24174747
32Pancreatic cancer_Homo sapiens_hsa052121.21004251
33Chemokine signaling pathway_Homo sapiens_hsa040621.20545768
34FoxO signaling pathway_Homo sapiens_hsa040681.19296060
35Amoebiasis_Homo sapiens_hsa051461.19035968
36Prostate cancer_Homo sapiens_hsa052151.14725943
37Endometrial cancer_Homo sapiens_hsa052131.11856823
38African trypanosomiasis_Homo sapiens_hsa051431.11644872
39Primary immunodeficiency_Homo sapiens_hsa053401.10399779
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09426349
41Herpes simplex infection_Homo sapiens_hsa051681.08758994
42Inositol phosphate metabolism_Homo sapiens_hsa005621.08239740
43Hematopoietic cell lineage_Homo sapiens_hsa046401.07323415
44Renal cell carcinoma_Homo sapiens_hsa052111.06174225
45Graft-versus-host disease_Homo sapiens_hsa053321.05093194
46Choline metabolism in cancer_Homo sapiens_hsa052311.03796645
47Prolactin signaling pathway_Homo sapiens_hsa049171.01193410
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94504082
49Apoptosis_Homo sapiens_hsa042100.92548040
50Colorectal cancer_Homo sapiens_hsa052100.92025042
51Pertussis_Homo sapiens_hsa051330.91534752
52Small cell lung cancer_Homo sapiens_hsa052220.90639926
53ErbB signaling pathway_Homo sapiens_hsa040120.90456553
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.90167036
55Hepatitis C_Homo sapiens_hsa051600.86842178
56Other glycan degradation_Homo sapiens_hsa005110.85780568
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85265716
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84694561
59Lysine degradation_Homo sapiens_hsa003100.82060421
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.80051684
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.78084277
62MicroRNAs in cancer_Homo sapiens_hsa052060.77830666
63Focal adhesion_Homo sapiens_hsa045100.77158188
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74095662
65Adherens junction_Homo sapiens_hsa045200.74057339
66GnRH signaling pathway_Homo sapiens_hsa049120.73006914
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72859220
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71606807
69Salmonella infection_Homo sapiens_hsa051320.71294345
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71097247
71mTOR signaling pathway_Homo sapiens_hsa041500.69002581
72Proteoglycans in cancer_Homo sapiens_hsa052050.67901143
73VEGF signaling pathway_Homo sapiens_hsa043700.67887512
74Autoimmune thyroid disease_Homo sapiens_hsa053200.67598138
75Insulin resistance_Homo sapiens_hsa049310.66023919
76Allograft rejection_Homo sapiens_hsa053300.65816576
77Estrogen signaling pathway_Homo sapiens_hsa049150.65618989
78Antigen processing and presentation_Homo sapiens_hsa046120.65389654
79ECM-receptor interaction_Homo sapiens_hsa045120.64393096
80ABC transporters_Homo sapiens_hsa020100.64298521
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63616586
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62148653
83Shigellosis_Homo sapiens_hsa051310.60412981
84MAPK signaling pathway_Homo sapiens_hsa040100.59595007
85Pathways in cancer_Homo sapiens_hsa052000.59181967
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58129012
87Phagosome_Homo sapiens_hsa041450.56697722
88HIF-1 signaling pathway_Homo sapiens_hsa040660.56406501
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.56259721
90Glioma_Homo sapiens_hsa052140.55734380
91HTLV-I infection_Homo sapiens_hsa051660.55500050
92Viral myocarditis_Homo sapiens_hsa054160.53157496
93Viral carcinogenesis_Homo sapiens_hsa052030.47762325
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47142286
95TGF-beta signaling pathway_Homo sapiens_hsa043500.46475336
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.46007002
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45631746
98Endocytosis_Homo sapiens_hsa041440.44127689
99Hedgehog signaling pathway_Homo sapiens_hsa043400.43309521
100Regulation of autophagy_Homo sapiens_hsa041400.42879592

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