NBPF2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1natural killer cell activation involved in immune response (GO:0002323)5.83872110
2anatomical structure regression (GO:0060033)5.77317449
3cellular response to exogenous dsRNA (GO:0071360)5.52523802
4monoubiquitinated protein deubiquitination (GO:0035520)5.33124899
5establishment of protein localization to Golgi (GO:0072600)5.24734826
6protein targeting to Golgi (GO:0000042)5.16526495
7retina layer formation (GO:0010842)5.04044246
8digestive tract morphogenesis (GO:0048546)4.77441538
9retrograde transport, vesicle recycling within Golgi (GO:0000301)4.74672524
10ncRNA catabolic process (GO:0034661)4.73336003
11cardiovascular system development (GO:0072358)4.67950630
12maintenance of gastrointestinal epithelium (GO:0030277)4.60486852
13pre-miRNA processing (GO:0031054)4.27158386
14protein K11-linked deubiquitination (GO:0035871)4.18916699
15regulation of helicase activity (GO:0051095)4.13910487
16pyrimidine ribonucleoside catabolic process (GO:0046133)4.10249959
17negative regulation of mast cell activation (GO:0033004)4.03805670
18regulation of B cell receptor signaling pathway (GO:0050855)4.01829790
19DNA integration (GO:0015074)4.01491937
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.89219247
21protein localization to Golgi apparatus (GO:0034067)3.86605414
22pituitary gland development (GO:0021983)3.67211546
23T-helper cell differentiation (GO:0042093)3.61483482
24CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.61483482
25T cell activation involved in immune response (GO:0002286)3.60736810
26fructose metabolic process (GO:0006000)3.53575673
27ovulation cycle (GO:0042698)3.51146429
28phosphatidylinositol acyl-chain remodeling (GO:0036149)3.49201363
29rRNA catabolic process (GO:0016075)3.45179062
30nucleoside diphosphate catabolic process (GO:0009134)3.38649496
31neutrophil activation involved in immune response (GO:0002283)3.31788823
32fucose catabolic process (GO:0019317)3.29234210
33L-fucose metabolic process (GO:0042354)3.29234210
34L-fucose catabolic process (GO:0042355)3.29234210
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.21414299
36alpha-beta T cell differentiation involved in immune response (GO:0002293)3.18489988
37alpha-beta T cell activation involved in immune response (GO:0002287)3.18489988
38T cell differentiation involved in immune response (GO:0002292)3.18489988
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17802053
40histone H3-K9 methylation (GO:0051567)3.11435637
41phosphatidylserine acyl-chain remodeling (GO:0036150)3.08701478
42piRNA metabolic process (GO:0034587)3.04929527
43cellular response to dsRNA (GO:0071359)3.01459293
44positive regulation of viral genome replication (GO:0045070)2.98830484
45epithelial structure maintenance (GO:0010669)2.96808719
46positive regulation of osteoblast proliferation (GO:0033690)2.95781688
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87896999
48melanocyte differentiation (GO:0030318)2.84462556
49negative regulation of B cell proliferation (GO:0030889)2.84010766
50DNA deamination (GO:0045006)2.83703099
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83038017
52CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.79578766
53natural killer cell activation (GO:0030101)2.78970578
54cilium or flagellum-dependent cell motility (GO:0001539)2.77473451
55sulfate transmembrane transport (GO:1902358)2.76749804
56poly(A)+ mRNA export from nucleus (GO:0016973)2.76019069
57positive regulation of smoothened signaling pathway (GO:0045880)2.74528221
58negative regulation of alpha-beta T cell activation (GO:0046636)2.72953260
59cytidine catabolic process (GO:0006216)2.70486079
60cytidine deamination (GO:0009972)2.70486079
61cytidine metabolic process (GO:0046087)2.70486079
62proximal/distal pattern formation (GO:0009954)2.69733062
63regulation of defense response to virus by host (GO:0050691)2.67420883
64regulation of collateral sprouting (GO:0048670)2.67094336
65positive regulation of T-helper 1 type immune response (GO:0002827)2.66705581
66positive regulation of granulocyte differentiation (GO:0030854)2.66280913
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65241631
68leukocyte degranulation (GO:0043299)2.63782297
69sodium-independent organic anion transport (GO:0043252)2.59461229
70regulation of T cell tolerance induction (GO:0002664)2.57573008
71male meiosis (GO:0007140)2.55837666
72lymphocyte activation involved in immune response (GO:0002285)2.54679191
73pigment cell differentiation (GO:0050931)2.54072135
74regulation of activation of Janus kinase activity (GO:0010533)2.53237873
75regulation of interleukin-8 secretion (GO:2000482)2.53203827
76smoothened signaling pathway (GO:0007224)2.51714695
77photoreceptor cell maintenance (GO:0045494)2.48947876
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48672965
79phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48590894
80negative regulation of alpha-beta T cell differentiation (GO:0046639)2.48207536
81positive regulation of hair follicle development (GO:0051798)2.47873480
82positive regulation of hair cycle (GO:0042635)2.47873480
83negative regulation of adaptive immune response (GO:0002820)2.47787362
84defense response to protozoan (GO:0042832)2.47411328
85CD4-positive, alpha-beta T cell activation (GO:0035710)2.47180667
86histone H3-K9 modification (GO:0061647)2.46869138
87auditory receptor cell stereocilium organization (GO:0060088)2.46447757
88peptidyl-lysine methylation (GO:0018022)2.45957181
89detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.44651071
90regulation of SMAD protein import into nucleus (GO:0060390)2.44580315
91positive regulation of neurological system process (GO:0031646)2.44118149
92sulfate transport (GO:0008272)2.43189885
93cellular response to zinc ion (GO:0071294)2.41720871
94alpha-beta T cell differentiation (GO:0046632)2.41322871
95activated T cell proliferation (GO:0050798)2.40352352
96regulation of T-helper 1 type immune response (GO:0002825)2.39940108
97DNA methylation involved in gamete generation (GO:0043046)2.38318465
98long-chain fatty acid biosynthetic process (GO:0042759)2.37676428
99nephron epithelium morphogenesis (GO:0072088)2.36744425
100nephron tubule morphogenesis (GO:0072078)2.36744425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.44793038
2VDR_22108803_ChIP-Seq_LS180_Human3.16870732
3GBX2_23144817_ChIP-Seq_PC3_Human2.86729849
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73326233
5ZNF274_21170338_ChIP-Seq_K562_Hela2.71032830
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.49188026
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47488130
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.20629317
9FUS_26573619_Chip-Seq_HEK293_Human2.17476218
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17010106
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13535608
12UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.01467684
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.96155789
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94624284
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94624284
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91605643
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87568695
18ER_23166858_ChIP-Seq_MCF-7_Human1.87444971
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86811122
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82157102
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81236478
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.80951134
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80586826
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75249727
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.74284969
26IGF1R_20145208_ChIP-Seq_DFB_Human1.73681908
27P300_19829295_ChIP-Seq_ESCs_Human1.72626491
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65196348
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63986201
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62349493
31DROSHA_22980978_ChIP-Seq_HELA_Human1.62077582
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.58526858
33EWS_26573619_Chip-Seq_HEK293_Human1.56828904
34TAF15_26573619_Chip-Seq_HEK293_Human1.55253499
35CBP_20019798_ChIP-Seq_JUKART_Human1.51428862
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51428862
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49405549
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.48122704
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.46431245
40GATA1_22025678_ChIP-Seq_K562_Human1.42768106
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41472821
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41233866
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40102762
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.39545097
45RNF2_27304074_Chip-Seq_NSC_Mouse1.38910805
46TCF4_23295773_ChIP-Seq_U87_Human1.38843752
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.38814218
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38472641
49BCAT_22108803_ChIP-Seq_LS180_Human1.38358930
50STAT3_23295773_ChIP-Seq_U87_Human1.37962119
51TP53_22573176_ChIP-Seq_HFKS_Human1.37902141
52AR_25329375_ChIP-Seq_VCAP_Human1.31955651
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31598136
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30970846
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30867871
56TCF4_22108803_ChIP-Seq_LS180_Human1.28764690
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.27793486
58GATA3_26560356_Chip-Seq_TH2_Human1.27640162
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26587417
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23589609
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22740771
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22057721
63SMAD4_21799915_ChIP-Seq_A2780_Human1.22004129
64CDX2_22108803_ChIP-Seq_LS180_Human1.21946752
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20007117
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19657121
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.19335998
68SOX2_19829295_ChIP-Seq_ESCs_Human1.17204777
69NANOG_19829295_ChIP-Seq_ESCs_Human1.17204777
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16434966
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16271921
72P53_22387025_ChIP-Seq_ESCs_Mouse1.15261635
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14705984
74RUNX2_22187159_ChIP-Seq_PCA_Human1.14619574
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.14471405
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.13703670
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13488478
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13295507
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.13184699
80TP53_16413492_ChIP-PET_HCT116_Human1.12926530
81ETV1_20927104_ChIP-Seq_GIST48_Human1.12452129
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.12175028
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12107901
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11364239
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.10834980
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10101730
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09339003
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08488397
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07885293
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.07671643
91RUNX_20019798_ChIP-Seq_JUKART_Human1.07087862
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06439638
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05233887
94TBL1_22424771_ChIP-Seq_293T_Human1.05186387
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04927639
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.04458549
97HNFA_21074721_ChIP-Seq_CACO-2_Human1.04000742
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.03909296
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.02967787
100AHR_22903824_ChIP-Seq_MCF-7_Human1.02841998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo5.10184336
2MP0003252_abnormal_bile_duct4.88242560
3MP0002928_abnormal_bile_duct4.25092165
4MP0002877_abnormal_melanocyte_morpholog3.54627505
5MP0008995_early_reproductive_senescence3.24901065
6MP0005408_hypopigmentation3.16812350
7MP0005187_abnormal_penis_morphology2.63009924
8MP0000372_irregular_coat_pigmentation2.58128665
9MP0003136_yellow_coat_color2.52473493
10MP0004133_heterotaxia2.48538373
11MP0000462_abnormal_digestive_system2.43774659
12MP0005377_hearing/vestibular/ear_phenot2.30622765
13MP0003878_abnormal_ear_physiology2.30622765
14MP0000631_abnormal_neuroendocrine_gland2.23755205
15MP0001835_abnormal_antigen_presentation2.17611899
16MP0000647_abnormal_sebaceous_gland2.15345018
17MP0006292_abnormal_olfactory_placode2.05800422
18MP0008004_abnormal_stomach_pH2.02839779
19MP0002095_abnormal_skin_pigmentation2.01884471
20MP0003950_abnormal_plasma_membrane2.00324702
21MP0001270_distended_abdomen1.94606549
22MP0000569_abnormal_digit_pigmentation1.94291256
23MP0005551_abnormal_eye_electrophysiolog1.92096565
24MP0004381_abnormal_hair_follicle1.90383041
25MP0005220_abnormal_exocrine_pancreas1.89333304
26MP0002277_abnormal_respiratory_mucosa1.87799407
27MP0003195_calcinosis1.86371754
28MP0003866_abnormal_defecation1.71980848
29MP0000371_diluted_coat_color1.70026407
30MP0000465_gastrointestinal_hemorrhage1.58546328
31MP0004043_abnormal_pH_regulation1.57516418
32MP0006054_spinal_hemorrhage1.56097982
33MP0005075_abnormal_melanosome_morpholog1.51180981
34MP0008877_abnormal_DNA_methylation1.50811995
35MP0003315_abnormal_perineum_morphology1.46125441
36MP0003786_premature_aging1.39421969
37MP0005253_abnormal_eye_physiology1.35501967
38MP0002102_abnormal_ear_morphology1.35475492
39MP0005646_abnormal_pituitary_gland1.33826601
40MP0003646_muscle_fatigue1.32954155
41MP0005171_absent_coat_pigmentation1.32641534
42MP0006072_abnormal_retinal_apoptosis1.28811550
43MP0002166_altered_tumor_susceptibility1.28146216
44MP0000566_synostosis1.26914254
45MP0001485_abnormal_pinna_reflex1.26910140
46MP0005645_abnormal_hypothalamus_physiol1.26635581
47MP0005174_abnormal_tail_pigmentation1.18553272
48MP0002938_white_spotting1.18433871
49MP0009785_altered_susceptibility_to1.17308978
50MP0005671_abnormal_response_to1.16428340
51MP0002282_abnormal_trachea_morphology1.16314102
52MP0005381_digestive/alimentary_phenotyp1.14328120
53MP0010386_abnormal_urinary_bladder1.14206719
54MP0001800_abnormal_humoral_immune1.08838414
55MP0001919_abnormal_reproductive_system1.01819932
56MP0003011_delayed_dark_adaptation1.01166143
57MP0000427_abnormal_hair_cycle0.98184358
58MP0001666_abnormal_nutrient_absorption0.97991214
59MP0002638_abnormal_pupillary_reflex0.97280188
60MP0001486_abnormal_startle_reflex0.96998959
61MP0005387_immune_system_phenotype0.96297946
62MP0001790_abnormal_immune_system0.96297946
63MP0005389_reproductive_system_phenotype0.95351894
64MP0002138_abnormal_hepatobiliary_system0.93391345
65MP0004742_abnormal_vestibular_system0.92838998
66MP0002148_abnormal_hypersensitivity_rea0.86264404
67MP0004145_abnormal_muscle_electrophysio0.84391261
68MP0002098_abnormal_vibrissa_morphology0.82931675
69MP0003045_fibrosis0.82892765
70MP0004147_increased_porphyrin_level0.78967035
71MP0002006_tumorigenesis0.76188360
72MP0002075_abnormal_coat/hair_pigmentati0.74327132
73MP0002452_abnormal_antigen_presenting0.73468975
74MP0002723_abnormal_immune_serum0.73373313
75MP0000383_abnormal_hair_follicle0.67680593
76MP0001501_abnormal_sleep_pattern0.67562316
77MP0003936_abnormal_reproductive_system0.66516633
78MP0001986_abnormal_taste_sensitivity0.66169672
79MP0004142_abnormal_muscle_tone0.65811375
80MP0001663_abnormal_digestive_system0.65739424
81MP0002419_abnormal_innate_immunity0.65591713
82MP0002163_abnormal_gland_morphology0.65159799
83MP0005275_abnormal_skin_tensile0.58348620
84MP0001119_abnormal_female_reproductive0.58178299
85MP0008872_abnormal_physiological_respon0.58169065
86MP0005000_abnormal_immune_tolerance0.55446972
87MP0008057_abnormal_DNA_replication0.55166108
88MP0008932_abnormal_embryonic_tissue0.54979029
89MP0002109_abnormal_limb_morphology0.54618842
90MP0000538_abnormal_urinary_bladder0.54388686
91MP0005025_abnormal_response_to0.53026934
92MP0002136_abnormal_kidney_physiology0.52380981
93MP0005503_abnormal_tendon_morphology0.52081125
94MP0000749_muscle_degeneration0.51219969
95MP0002420_abnormal_adaptive_immunity0.50840786
96MP0010155_abnormal_intestine_physiology0.50712420
97MP0009764_decreased_sensitivity_to0.49894186
98MP0001984_abnormal_olfaction0.49617268
99MP0001958_emphysema0.48580130
100MP0000579_abnormal_nail_morphology0.48274419

Predicted human phenotypes

RankGene SetZ-score
1Alveolar cell carcinoma (HP:0006519)7.48951468
2Neoplasm of the tracheobronchial system (HP:0100552)7.18380053
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.53045360
4Ependymoma (HP:0002888)4.42979016
5Abnormality of the astrocytes (HP:0100707)3.51389179
6Astrocytoma (HP:0009592)3.51389179
7Pulmonary infiltrates (HP:0002113)3.49682164
8Infantile muscular hypotonia (HP:0008947)3.44201059
9Congenital, generalized hypertrichosis (HP:0004540)3.40804954
10Glioma (HP:0009733)3.39255346
11Neoplasm of the heart (HP:0100544)3.27103948
12Stomach cancer (HP:0012126)2.97215129
13Generalized hypopigmentation of hair (HP:0011358)2.93609787
14Neonatal short-limb short stature (HP:0008921)2.85368719
15Elevated erythrocyte sedimentation rate (HP:0003565)2.83580590
16Concave nail (HP:0001598)2.73477545
17Tubulointerstitial nephritis (HP:0001970)2.68324573
18Abnormality of the renal cortex (HP:0011035)2.67120182
19Neoplasm of the lung (HP:0100526)2.66144899
20Mesomelia (HP:0003027)2.61223502
21Abnormality of incisor morphology (HP:0011063)2.59621317
22Abnormality of the renal medulla (HP:0100957)2.58837452
23Abnormality of T cell physiology (HP:0011840)2.56052347
24Hemiplegia (HP:0002301)2.53934782
25Stomatitis (HP:0010280)2.50943868
26Hamartoma of the eye (HP:0010568)2.49275795
27Attenuation of retinal blood vessels (HP:0007843)2.48652511
28Neoplasm of the respiratory system (HP:0100606)2.42289846
29Nephronophthisis (HP:0000090)2.37809906
30Chronic hepatic failure (HP:0100626)2.37635289
31Congenital stationary night blindness (HP:0007642)2.36093350
32Agnosia (HP:0010524)2.34485479
33Enlarged epiphyses (HP:0010580)2.30943072
34Decreased central vision (HP:0007663)2.29923701
35Palpebral edema (HP:0100540)2.28259203
36Duplicated collecting system (HP:0000081)2.27872352
37Conical tooth (HP:0000698)2.24386714
38Tracheomalacia (HP:0002779)2.23383875
39Hypoplastic iliac wings (HP:0002866)2.21226594
40Abnormality of T cells (HP:0002843)2.15678717
41Clubbing of toes (HP:0100760)2.13126397
42Keratoconus (HP:0000563)2.11018609
43Increased corneal curvature (HP:0100692)2.11018609
44True hermaphroditism (HP:0010459)2.09733466
45Lymphangioma (HP:0100764)2.09729106
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07809428
47Tubular atrophy (HP:0000092)2.07796584
48Follicular hyperkeratosis (HP:0007502)2.05611323
49Spondylolisthesis (HP:0003302)2.01238242
50Abnormality of the nasal septum (HP:0000419)2.00228653
51Hemoptysis (HP:0002105)1.98045054
52Pancreatic cysts (HP:0001737)1.96645310
53Ocular albinism (HP:0001107)1.96525698
54Abnormality of the renal collecting system (HP:0004742)1.95535150
55Bronchomalacia (HP:0002780)1.93387182
56Morphological abnormality of the middle ear (HP:0008609)1.93173832
57Abnormality of the pleura (HP:0002103)1.92074701
58Abnormal sex determination (HP:0012244)1.90029184
59Sex reversal (HP:0012245)1.90029184
60Congenital sensorineural hearing impairment (HP:0008527)1.89938882
61Abnormality of the pons (HP:0007361)1.86867532
62Ectopic kidney (HP:0000086)1.86706517
63Abnormality of the proximal phalanges of the hand (HP:0009834)1.83392583
64Cerebellar dysplasia (HP:0007033)1.83009439
65Neoplasm of striated muscle (HP:0009728)1.82869344
66Type II lissencephaly (HP:0007260)1.81688590
67Abnormal drinking behavior (HP:0030082)1.78249192
68Polydipsia (HP:0001959)1.78249192
69Symphalangism affecting the phalanges of the hand (HP:0009773)1.75066068
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.74109417
71Abnormality of chloride homeostasis (HP:0011422)1.71796243
72Abnormality of the labia majora (HP:0012881)1.70186188
73Premature graying of hair (HP:0002216)1.70124157
74Short middle phalanx of finger (HP:0005819)1.69786933
75Adactyly (HP:0009776)1.69327045
76Abnormality of midbrain morphology (HP:0002418)1.68520613
77Molar tooth sign on MRI (HP:0002419)1.68520613
78Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68197108
79Fibular aplasia (HP:0002990)1.68125312
80Hypoplastic labia majora (HP:0000059)1.67923876
81Chest pain (HP:0100749)1.67502533
82Tented upper lip vermilion (HP:0010804)1.66086668
83Optic neuritis (HP:0100653)1.66020474
84Retrobulbar optic neuritis (HP:0100654)1.66020474
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64197998
86Abnormal rod and cone electroretinograms (HP:0008323)1.63527580
87Abnormality of the dental pulp (HP:0006479)1.63321485
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63131120
89Cerebral edema (HP:0002181)1.62236737
90Hypopigmentation of the fundus (HP:0007894)1.61485084
91Synostosis involving the elbow (HP:0003938)1.61433294
92Humeroradial synostosis (HP:0003041)1.61433294
93Depressed nasal tip (HP:0000437)1.60892141
94Macular degeneration (HP:0000608)1.60517228
95Dyschromatopsia (HP:0007641)1.59875840
96Abnormality of the middle phalanges of the toes (HP:0010183)1.59458341
97Absent frontal sinuses (HP:0002688)1.58668443
98Abnormality of the costochondral junction (HP:0000919)1.58470796
99Progressive macrocephaly (HP:0004481)1.58163583
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.55899129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF13.83896200
2STK38L3.49390980
3TAOK33.31461966
4WNK43.12131828
5BLK3.10201928
6MAP4K23.03827160
7STK242.91658658
8FRK2.56601927
9PRKCI2.32351123
10TXK1.99711364
11MAP3K41.98294076
12TNIK1.93804482
13EIF2AK31.90652528
14MST1R1.87453792
15TEC1.80875857
16JAK31.75544964
17MAP3K51.73325526
18ZAK1.73152747
19IKBKB1.54072144
20GRK11.52173438
21STK391.47705452
22CAMK1D1.41245711
23ITK1.40154337
24BRSK21.27384881
25ADRBK21.24827748
26AKT31.24016214
27EIF2AK11.21400271
28CDK81.18913970
29IRAK41.16275170
30MATK1.15876551
31PIK3CG1.15780785
32STK31.14742919
33ERBB21.14006399
34WNK31.13758939
35CAMK1G1.12567087
36TRPM71.09535458
37INSRR1.08102865
38MUSK1.05371878
39CASK1.00621274
40BMPR1B0.97325089
41MAP2K60.96325857
42OXSR10.94563054
43MKNK10.94127768
44PINK10.93147298
45IKBKE0.91365816
46FGFR10.89961346
47IRAK10.89250183
48PAK30.88146206
49KIT0.87187176
50WNK10.85936777
51MARK30.84844747
52SYK0.84263139
53GRK70.83575631
54MST40.83383178
55TRIM280.82188749
56NME10.81268736
57FGFR30.80844142
58MKNK20.80204897
59WEE10.79367935
60PTK2B0.76591469
61NUAK10.76375988
62PIK3CA0.73268173
63LCK0.69810583
64CAMK40.66625795
65BRD40.66596549
66NLK0.65275698
67CAMK10.64828994
68ADRBK10.59112263
69CHUK0.53933024
70LYN0.53468216
71ATR0.53157704
72PRKCE0.52703497
73LMTK20.51412229
74MAP3K70.51306205
75PRKAA10.50360954
76OBSCN0.49473638
77CCNB10.49050862
78PLK20.47943008
79BTK0.46075648
80ACVR1B0.45682340
81BMPR20.43553717
82IGF1R0.42917714
83PRKCQ0.41311567
84FGFR20.41273533
85MAPKAPK50.40694940
86ATM0.40121292
87BCKDK0.38447781
88EPHA20.38005594
89MAPK130.37810446
90PRKAA20.35844580
91MET0.35447129
92SIK30.34893448
93PRKACA0.34314990
94FER0.34135514
95PRKG10.33202745
96PNCK0.28632750
97PRKCA0.27054420
98MAP3K140.26056946
99TNK20.25846148
100CSNK1D0.25084532

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.59012229
2Asthma_Homo sapiens_hsa053102.78620698
3Sulfur metabolism_Homo sapiens_hsa009202.75039712
4Homologous recombination_Homo sapiens_hsa034402.69406907
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59322879
6Allograft rejection_Homo sapiens_hsa053302.54431555
7Phototransduction_Homo sapiens_hsa047442.52673043
8Graft-versus-host disease_Homo sapiens_hsa053322.50310121
9Autoimmune thyroid disease_Homo sapiens_hsa053202.40235740
10Fanconi anemia pathway_Homo sapiens_hsa034602.29215001
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13681781
12Nitrogen metabolism_Homo sapiens_hsa009102.12744888
13Type I diabetes mellitus_Homo sapiens_hsa049402.12338174
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05238146
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.04110471
16Hedgehog signaling pathway_Homo sapiens_hsa043402.00862761
17Olfactory transduction_Homo sapiens_hsa047401.68099517
18Basal cell carcinoma_Homo sapiens_hsa052171.63382118
19Staphylococcus aureus infection_Homo sapiens_hsa051501.56831594
20Protein export_Homo sapiens_hsa030601.56256354
21Primary immunodeficiency_Homo sapiens_hsa053401.54855256
22Arachidonic acid metabolism_Homo sapiens_hsa005901.52487713
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.46788489
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46390738
25Basal transcription factors_Homo sapiens_hsa030221.44851284
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39778695
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39550101
28Ether lipid metabolism_Homo sapiens_hsa005651.37293209
29Oxidative phosphorylation_Homo sapiens_hsa001901.36222652
30Antigen processing and presentation_Homo sapiens_hsa046121.29288417
31Leishmaniasis_Homo sapiens_hsa051401.27103058
32Regulation of autophagy_Homo sapiens_hsa041401.21346306
33RNA degradation_Homo sapiens_hsa030181.20095548
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20091656
35Mineral absorption_Homo sapiens_hsa049781.19305478
36Hematopoietic cell lineage_Homo sapiens_hsa046401.17748560
37RNA polymerase_Homo sapiens_hsa030201.14492583
38Parkinsons disease_Homo sapiens_hsa050121.10610369
39Systemic lupus erythematosus_Homo sapiens_hsa053221.07559716
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06133262
41Taste transduction_Homo sapiens_hsa047421.04862568
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03502852
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.02811917
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00723901
45Herpes simplex infection_Homo sapiens_hsa051680.99864606
46Rheumatoid arthritis_Homo sapiens_hsa053230.98262646
47Dorso-ventral axis formation_Homo sapiens_hsa043200.95147934
48Caffeine metabolism_Homo sapiens_hsa002320.93840894
49Circadian rhythm_Homo sapiens_hsa047100.93822887
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92901756
51Fructose and mannose metabolism_Homo sapiens_hsa000510.92608364
52Huntingtons disease_Homo sapiens_hsa050160.88481880
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88338850
54ABC transporters_Homo sapiens_hsa020100.83508978
55Malaria_Homo sapiens_hsa051440.83496906
56Salivary secretion_Homo sapiens_hsa049700.83305094
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.81846610
58Ovarian steroidogenesis_Homo sapiens_hsa049130.81749131
59African trypanosomiasis_Homo sapiens_hsa051430.81619402
60Propanoate metabolism_Homo sapiens_hsa006400.81440113
61RNA transport_Homo sapiens_hsa030130.79976788
62Legionellosis_Homo sapiens_hsa051340.79706174
63Ribosome_Homo sapiens_hsa030100.78436188
64Chemical carcinogenesis_Homo sapiens_hsa052040.76076849
65Proteasome_Homo sapiens_hsa030500.71431573
66Measles_Homo sapiens_hsa051620.67623851
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67534188
68Protein digestion and absorption_Homo sapiens_hsa049740.66822376
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.64624042
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.63342773
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62645973
72Lysine degradation_Homo sapiens_hsa003100.61177130
73Retinol metabolism_Homo sapiens_hsa008300.58363097
74Viral myocarditis_Homo sapiens_hsa054160.57017501
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.54744930
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51456965
77Alzheimers disease_Homo sapiens_hsa050100.48999205
78Influenza A_Homo sapiens_hsa051640.48465946
79Osteoclast differentiation_Homo sapiens_hsa043800.48277315
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.48123182
81Complement and coagulation cascades_Homo sapiens_hsa046100.46855870
82Oocyte meiosis_Homo sapiens_hsa041140.44266718
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41870878
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41858650
85Butanoate metabolism_Homo sapiens_hsa006500.41151872
86Purine metabolism_Homo sapiens_hsa002300.40191840
87One carbon pool by folate_Homo sapiens_hsa006700.36775906
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36616833
89T cell receptor signaling pathway_Homo sapiens_hsa046600.36060806
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33590074
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33563403
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32861174
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32434355
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30676217
95ECM-receptor interaction_Homo sapiens_hsa045120.30477473
96cAMP signaling pathway_Homo sapiens_hsa040240.30230491
97TGF-beta signaling pathway_Homo sapiens_hsa043500.29676785
98Platelet activation_Homo sapiens_hsa046110.29448288
99Notch signaling pathway_Homo sapiens_hsa043300.27197770
100Serotonergic synapse_Homo sapiens_hsa047260.26494926

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