ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.38906639
2	positive regulation of catecholamine secretion (GO:0033605)	9.08418024
3	regulation of phosphoprotein phosphatase activity (GO:0043666)	9.06618091
4	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	8.67625644
5	multicellular organism reproduction (GO:0032504)	7.55279312
6	synapsis (GO:0007129)	7.46650201
7	acrosome reaction (GO:0007340)	7.17888792
8	binding of sperm to zona pellucida (GO:0007339)	6.79446612
9	spermatid development (GO:0007286)	6.73356180
10	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.49498395
11	sperm motility (GO:0030317)	6.34680213
12	potassium ion export (GO:0071435)	5.98540195
13	regulation of oxidative stress-induced neuron death (GO:1903203)	5.97145558
14	regulation of oxidative phosphorylation (GO:0002082)	5.89587404
15	motile cilium assembly (GO:0044458)	5.80012529
16	sperm-egg recognition (GO:0035036)	5.68014624
17	TOR signaling (GO:0031929)	5.67155432
18	cilium or flagellum-dependent cell motility (GO:0001539)	5.65418055
19	axonemal dynein complex assembly (GO:0070286)	5.47004518
20	epithelial cilium movement (GO:0003351)	5.34567305
21	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.28085920
22	protein-DNA complex disassembly (GO:0032986)	5.26663050
23	nucleosome disassembly (GO:0006337)	5.26663050
24	polyamine biosynthetic process (GO:0006596)	5.20666949
25	organic cation transport (GO:0015695)	5.18556405
26	relaxation of smooth muscle (GO:0044557)	5.07030956
27	reproduction (GO:0000003)	5.01771549
28	Leydig cell differentiation (GO:0033327)	4.94531539
29	cell-cell recognition (GO:0009988)	4.93066194
30	indole-containing compound catabolic process (GO:0042436)	4.90459429
31	indolalkylamine catabolic process (GO:0046218)	4.90459429
32	tryptophan catabolic process (GO:0006569)	4.90459429
33	chromosome organization involved in meiosis (GO:0070192)	4.89593829
34	male sex determination (GO:0030238)	4.89390623
35	activation of protein kinase B activity (GO:0032148)	4.86628673
36	cGMP-mediated signaling (GO:0019934)	4.80885500
37	positive regulation of glycolytic process (GO:0045821)	4.63353507
38	DNA double-strand break processing (GO:0000729)	4.61792322
39	DNA synthesis involved in DNA repair (GO:0000731)	4.59756812
40	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	4.59053218
41	single fertilization (GO:0007338)	4.57687171
42	regulation of dopamine secretion (GO:0014059)	4.49217257
43	acrosome assembly (GO:0001675)	4.45664882
44	androgen biosynthetic process (GO:0006702)	4.40392544
45	cilium movement (GO:0003341)	4.34340233
46	regulation of autophagic vacuole assembly (GO:2000785)	4.33569819
47	meiotic nuclear division (GO:0007126)	4.32246740
48	regulation of hydrogen peroxide-induced cell death (GO:1903205)	4.19908602
49	membrane repolarization during action potential (GO:0086011)	4.18586743
50	negative regulation of response to reactive oxygen species (GO:1901032)	4.15106107
51	germ cell development (GO:0007281)	4.05920265
52	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	4.05614029
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.04284464
54	glutamine family amino acid catabolic process (GO:0009065)	4.02765860
55	regulation of cellular respiration (GO:0043457)	3.96995484
56	tongue development (GO:0043586)	3.95621302
57	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.91919193
58	tryptophan metabolic process (GO:0006568)	3.90400501
59	histone exchange (GO:0043486)	3.84146394
60	protein polymerization (GO:0051258)	3.80014990
61	cellular biogenic amine biosynthetic process (GO:0042401)	3.78499339
62	glycogen metabolic process (GO:0005977)	3.75852581
63	response to acidic pH (GO:0010447)	3.74450613
64	amine biosynthetic process (GO:0009309)	3.72397238
65	cellular glucan metabolic process (GO:0006073)	3.71977745
66	glucan metabolic process (GO:0044042)	3.71977745
67	ventricular system development (GO:0021591)	3.68091824
68	regulation of acrosome reaction (GO:0060046)	3.63134096
69	coenzyme catabolic process (GO:0009109)	3.57488628
70	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.56434791
71	DNA methylation involved in gamete generation (GO:0043046)	3.53734448
72	histone H3-K9 demethylation (GO:0033169)	3.52647510
73	oogenesis (GO:0048477)	3.45579836
74	regulation of vacuole organization (GO:0044088)	3.43025826
75	aspartate family amino acid catabolic process (GO:0009068)	3.42915337
76	piRNA metabolic process (GO:0034587)	3.41049762
77	membrane repolarization (GO:0086009)	3.40601299
78	regulation of phosphatase activity (GO:0010921)	3.40005081
79	ectoderm development (GO:0007398)	3.38609291
80	synaptonemal complex assembly (GO:0007130)	3.37647922
81	fertilization (GO:0009566)	3.36287201
82	calcium ion-dependent exocytosis (GO:0017156)	3.35627298
83	oligosaccharide biosynthetic process (GO:0009312)	3.35200103
84	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.30342527
85	positive regulation of amine transport (GO:0051954)	3.27528708
86	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.27452242
87	dicarboxylic acid biosynthetic process (GO:0043650)	3.23446275
88	indolalkylamine metabolic process (GO:0006586)	3.22691483
89	potassium ion import (GO:0010107)	3.21049493
90	diacylglycerol metabolic process (GO:0046339)	3.19068982
91	glutathione biosynthetic process (GO:0006750)	3.11019385
92	cellular response to toxic substance (GO:0097237)	3.09285399
93	synaptonemal complex organization (GO:0070193)	3.09199073
94	fusion of sperm to egg plasma membrane (GO:0007342)	3.08482833
95	negative regulation of JNK cascade (GO:0046329)	3.05022835
96	detection of chemical stimulus involved in sensory perception (GO:0050907)	3.02470831
97	polyamine metabolic process (GO:0006595)	3.02262903
98	behavioral response to nicotine (GO:0035095)	2.99760796
99	diterpenoid biosynthetic process (GO:0016102)	2.96640589
100	receptor catabolic process (GO:0032801)	2.93879321

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.70336298
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.29315400
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.98266274
4	ESR1_20079471_ChIP-ChIP_T-47D_Human	4.58468368
5	VDR_22108803_ChIP-Seq_LS180_Human	2.95525820
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.75433538
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.72269433
8	GATA1_22025678_ChIP-Seq_K562_Human	2.68545172
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.56408795
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.56025880
11	FUS_26573619_Chip-Seq_HEK293_Human	2.45577078
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40755678
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.38003241
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.37873880
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37303055
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.30681706
17	AHR_22903824_ChIP-Seq_MCF-7_Human	2.10873762
18	ARNT_22903824_ChIP-Seq_MCF-7_Human	2.05355611
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01710126
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.92047183
21	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.78828743
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.78039407
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.78039407
24	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.68246290
25	ZNF274_21170338_ChIP-Seq_K562_Hela	1.68191136
26	NANOG_20526341_ChIP-Seq_ESCs_Human	1.68153611
27	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64376773
28	TBL1_22424771_ChIP-Seq_293T_Human	1.59979892
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57992570
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57992570
31	RAC3_21632823_ChIP-Seq_H3396_Human	1.55980989
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53548402
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.52546919
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.46995144
35	AR_21909140_ChIP-Seq_LNCAP_Human	1.44160048
36	RUNX2_22187159_ChIP-Seq_PCA_Human	1.43091271
37	ERA_21632823_ChIP-Seq_H3396_Human	1.39325391
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.38054062
39	STAT3_23295773_ChIP-Seq_U87_Human	1.34365627
40	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.33577144
41	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.31987634
42	HOXB7_26014856_ChIP-Seq_BT474_Human	1.30787451
43	P300_19829295_ChIP-Seq_ESCs_Human	1.30197680
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30071671
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29771194
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29693410
47	EWS_26573619_Chip-Seq_HEK293_Human	1.27793084
48	RXR_22108803_ChIP-Seq_LS180_Human	1.26843984
49	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26633627
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24178289
51	PHF8_20622853_ChIP-Seq_HELA_Human	1.23476251
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.23005473
53	AR_25329375_ChIP-Seq_VCAP_Human	1.22951812
54	NFYB_21822215_ChIP-Seq_K562_Human	1.22003856
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21297752
56	EZH2_22144423_ChIP-Seq_EOC_Human	1.19611641
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.18372159
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.16785235
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.15425241
60	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.13340223
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12693412
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12693412
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11712763
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10687526
65	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.10101860
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09828557
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09123420
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.08621093
69	RBPJ_21746931_ChIP-Seq_IB4_Human	1.06211093
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04290579
71	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02505510
72	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.02225568
73	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02200197
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01528831
75	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99954325
76	SMC4_20622854_ChIP-Seq_HELA_Human	0.99009266
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98088719
78	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97961727
79	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.97829504
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.97645114
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97566804
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.96524649
83	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.96225163
84	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.95659192
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94856433
86	NFYA_21822215_ChIP-Seq_K562_Human	0.93959374
87	ZNF263_19887448_ChIP-Seq_K562_Human	0.93326646
88	TCF4_23295773_ChIP-Seq_U87_Human	0.93167329
89	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.92657613
90	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91008507
91	ELF5_23300383_ChIP-Seq_T47D_Human	0.90864384
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90101558
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89969848
94	NCOR_22424771_ChIP-Seq_293T_Human	0.89891763
95	CTCF_27219007_Chip-Seq_Bcells_Human	0.89090404
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88630366
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88564102
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88238872
99	TP53_18474530_ChIP-ChIP_U2OS_Human	0.87355435
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85510402

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.63301121
2	MP0008004_abnormal_stomach_pH	5.69003867
3	MP0003315_abnormal_perineum_morphology	5.55369912
4	MP0002160_abnormal_reproductive_system	3.79270842
5	MP0003136_yellow_coat_color	3.10151545
6	MP0008995_early_reproductive_senescence	3.04851784
7	MP0003698_abnormal_male_reproductive	2.97164395
8	MP0005360_urolithiasis	2.97119128
9	MP0001929_abnormal_gametogenesis	2.83093794
10	MP0002132_abnormal_respiratory_system	2.30779384
11	MP0001984_abnormal_olfaction	2.30551282
12	MP0003045_fibrosis	2.28029762
13	MP0005646_abnormal_pituitary_gland	2.23409053
14	MP0005647_abnormal_sex_gland	2.12065830
15	MP0005187_abnormal_penis_morphology	2.01974252
16	MP0002210_abnormal_sex_determination	1.98281667
17	MP0010030_abnormal_orbit_morphology	1.92824363
18	MP0005389_reproductive_system_phenotype	1.81569957
19	MP0005058_abnormal_lysosome_morphology	1.77555140
20	MP0005248_abnormal_Harderian_gland	1.75741979
21	MP0001664_abnormal_digestion	1.75538766
22	MP0010386_abnormal_urinary_bladder	1.72011579
23	MP0001145_abnormal_male_reproductive	1.68971637
24	MP0009697_abnormal_copulation	1.64517171
25	MP0003718_maternal_effect	1.62425304
26	MP0002249_abnormal_larynx_morphology	1.62234875
27	MP0005174_abnormal_tail_pigmentation	1.59975304
28	MP0000653_abnormal_sex_gland	1.57081203
29	MP0002161_abnormal_fertility/fecundity	1.52113050
30	MP0003938_abnormal_ear_development	1.48311764
31	MP0006072_abnormal_retinal_apoptosis	1.42390277
32	MP0000538_abnormal_urinary_bladder	1.41919711
33	MP0000537_abnormal_urethra_morphology	1.34547938
34	MP0005083_abnormal_biliary_tract	1.29877204
35	MP0001905_abnormal_dopamine_level	1.27693554
36	MP0010368_abnormal_lymphatic_system	1.25595397
37	MP0008058_abnormal_DNA_repair	1.23875154
38	MP0000678_abnormal_parathyroid_gland	1.22633621
39	MP0005499_abnormal_olfactory_system	1.20570267
40	MP0005394_taste/olfaction_phenotype	1.20570267
41	MP0005551_abnormal_eye_electrophysiolog	1.19940733
42	MP0002638_abnormal_pupillary_reflex	1.16190508
43	MP0000631_abnormal_neuroendocrine_gland	1.16076208
44	MP0001188_hyperpigmentation	1.15583844
45	MP0001502_abnormal_circadian_rhythm	1.12376814
46	MP0008057_abnormal_DNA_replication	1.12236235
47	MP0001501_abnormal_sleep_pattern	1.10650433
48	MP0000569_abnormal_digit_pigmentation	1.07498794
49	MP0005395_other_phenotype	1.05941454
50	MP0006036_abnormal_mitochondrial_physio	1.05610555
51	MP0002282_abnormal_trachea_morphology	1.03997854
52	MP0003936_abnormal_reproductive_system	1.02303722
53	MP0000427_abnormal_hair_cycle	0.99514952
54	MP0000465_gastrointestinal_hemorrhage	0.97891654
55	MP0003195_calcinosis	0.97408456
56	MP0004381_abnormal_hair_follicle	0.95904273
57	MP0000470_abnormal_stomach_morphology	0.94610705
58	MP0002090_abnormal_vision	0.93334343
59	MP0001661_extended_life_span	0.92259424
60	MP0005253_abnormal_eye_physiology	0.91910745
61	MP0001529_abnormal_vocalization	0.91536472
62	MP0002127_abnormal_cardiovascular_syste	0.90255125
63	MP0003693_abnormal_embryo_hatching	0.89339797
64	MP0001919_abnormal_reproductive_system	0.89010229
65	MP0004085_abnormal_heartbeat	0.86753340
66	MP0002233_abnormal_nose_morphology	0.84066836
67	MP0003632_abnormal_nervous_system	0.83579716
68	MP0010094_abnormal_chromosome_stability	0.81443283
69	MP0006276_abnormal_autonomic_nervous	0.80272076
70	MP0003890_abnormal_embryonic-extraembry	0.76095303
71	MP0000613_abnormal_salivary_gland	0.75932374
72	MP0002277_abnormal_respiratory_mucosa	0.72063130
73	MP0002102_abnormal_ear_morphology	0.71626376
74	MP0008877_abnormal_DNA_methylation	0.71513205
75	MP0008789_abnormal_olfactory_epithelium	0.71478928
76	MP0002168_other_aberrant_phenotype	0.71253086
77	MP0003786_premature_aging	0.70988294
78	MP0000230_abnormal_systemic_arterial	0.67144475
79	MP0001764_abnormal_homeostasis	0.67143946
80	MP0002272_abnormal_nervous_system	0.65796654
81	MP0001968_abnormal_touch/_nociception	0.65059801
82	MP0004084_abnormal_cardiac_muscle	0.64825970
83	MP0003631_nervous_system_phenotype	0.62752471
84	MP0009046_muscle_twitch	0.60276410
85	MP0003699_abnormal_female_reproductive	0.56867343
86	MP0001485_abnormal_pinna_reflex	0.56708733
87	MP0006035_abnormal_mitochondrial_morpho	0.56063622
88	MP0002009_preneoplasia	0.55715137
89	MP0009840_abnormal_foam_cell	0.55022208
90	MP0001849_ear_inflammation	0.53793167
91	MP0000534_abnormal_ureter_morphology	0.53598522
92	MP0001756_abnormal_urination	0.53562273
93	MP0000647_abnormal_sebaceous_gland	0.52750471
94	MP0003635_abnormal_synaptic_transmissio	0.52740571
95	MP0002752_abnormal_somatic_nervous	0.51654469
96	MP0002938_white_spotting	0.51599318
97	MP0004272_abnormal_basement_membrane	0.50355183
98	MP0008961_abnormal_basal_metabolism	0.49766195
99	MP0003935_abnormal_craniofacial_develop	0.49657160
100	MP0000015_abnormal_ear_pigmentation	0.48572287

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the uterus (HP:0000013)	6.43389390
2	Sex reversal (HP:0012245)	6.04947686
3	Abnormal sex determination (HP:0012244)	6.04947686
4	Resting tremor (HP:0002322)	5.46517253
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.11364289
6	Reduced antithrombin III activity (HP:0001976)	4.98713346
7	Gonadal dysgenesis (HP:0000133)	4.88966498
8	Male pseudohermaphroditism (HP:0000037)	4.70388868
9	Aplasia/hypoplasia of the uterus (HP:0008684)	4.66220279
10	Absent/shortened dynein arms (HP:0200106)	4.60188311
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.60188311
12	Abnormality of the columella (HP:0009929)	4.52518969
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.51214491
14	Abnormal ciliary motility (HP:0012262)	4.48307489
15	Facial hemangioma (HP:0000329)	4.42280959
16	Cerebellar dysplasia (HP:0007033)	4.30978892
17	Ventricular fibrillation (HP:0001663)	4.30227434
18	Protruding tongue (HP:0010808)	3.97934360
19	Colitis (HP:0002583)	3.91097357
20	Type II lissencephaly (HP:0007260)	3.81098303
21	Abnormal respiratory motile cilium morphology (HP:0005938)	3.55821969
22	Abnormal respiratory epithelium morphology (HP:0012253)	3.55821969
23	Urinary urgency (HP:0000012)	3.54455150
24	Postural instability (HP:0002172)	3.42130004
25	Infertility (HP:0000789)	3.41941982
26	Capillary hemangiomas (HP:0005306)	3.29944000
27	Thoracic kyphosis (HP:0002942)	3.25271265
28	Self-mutilation (HP:0000742)	3.14773463
29	Germ cell neoplasia (HP:0100728)	3.08714775
30	True hermaphroditism (HP:0010459)	3.07314276
31	Thoracolumbar scoliosis (HP:0002944)	3.04196165
32	Occipital encephalocele (HP:0002085)	2.96318796
33	Abnormality of the intrinsic pathway (HP:0010989)	2.95401350
34	Pancreatic fibrosis (HP:0100732)	2.86065212
35	Rhinitis (HP:0012384)	2.82254100
36	Pancreatic cysts (HP:0001737)	2.70186544
37	Prolonged QT interval (HP:0001657)	2.67546931
38	Congenital sensorineural hearing impairment (HP:0008527)	2.59667158
39	Retinal dysplasia (HP:0007973)	2.51774044
40	Bile duct proliferation (HP:0001408)	2.47936325
41	Abnormal biliary tract physiology (HP:0012439)	2.47936325
42	Inflammation of the large intestine (HP:0002037)	2.45916572
43	Abnormal glycosylation (HP:0012345)	2.44540038
44	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.44540038
45	Abnormal protein N-linked glycosylation (HP:0012347)	2.44540038
46	Abnormal protein glycosylation (HP:0012346)	2.44540038
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.37844209
48	Retinal atrophy (HP:0001105)	2.37053189
49	Cystic liver disease (HP:0006706)	2.35321406
50	Sensory axonal neuropathy (HP:0003390)	2.34571965
51	Birth length less than 3rd percentile (HP:0003561)	2.33911548
52	Abnormality of the thoracic spine (HP:0100711)	2.29478916
53	Abnormality of the lumbar spine (HP:0100712)	2.28852524
54	Abnormality of chromosome stability (HP:0003220)	2.27126681
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20370946
56	Gastrointestinal inflammation (HP:0004386)	2.18986331
57	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.17579695
58	Absent thumb (HP:0009777)	2.15876766
59	Anterior segment dysgenesis (HP:0007700)	2.15615607
60	Anencephaly (HP:0002323)	2.11766191
61	Squamous cell carcinoma (HP:0002860)	2.11698776
62	Clumsiness (HP:0002312)	2.11675341
63	High anterior hairline (HP:0009890)	2.11354373
64	Inability to walk (HP:0002540)	2.10556484
65	Abnormality of the ileum (HP:0001549)	2.07314552
66	Absent speech (HP:0001344)	2.06653700
67	Syncope (HP:0001279)	2.01941752
68	Unsteady gait (HP:0002317)	2.00496678
69	Abnormality of the frontal sinuses (HP:0002687)	1.99137967
70	Hypoplasia of the pons (HP:0012110)	1.98994086
71	Abnormality of the pons (HP:0007361)	1.97310021
72	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.95725070
73	Hypothermia (HP:0002045)	1.93684646
74	Sloping forehead (HP:0000340)	1.91305624
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90584856
76	Bronchiectasis (HP:0002110)	1.89896725
77	Ectopic kidney (HP:0000086)	1.89810440
78	Meckel diverticulum (HP:0002245)	1.88506810
79	Enlarged kidneys (HP:0000105)	1.87459465
80	Chronic sinusitis (HP:0011109)	1.85511277
81	Duodenal stenosis (HP:0100867)	1.84225074
82	Small intestinal stenosis (HP:0012848)	1.84225074
83	Pili torti (HP:0003777)	1.82131697
84	Buphthalmos (HP:0000557)	1.80360999
85	Coxa valga (HP:0002673)	1.80234612
86	Abnormality of cochlea (HP:0000375)	1.79827706
87	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.77702217
88	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.77702217
89	Abnormal pancreas size (HP:0012094)	1.75747522
90	Atonic seizures (HP:0010819)	1.71524213
91	Furrowed tongue (HP:0000221)	1.70238015
92	Abnormality of macular pigmentation (HP:0008002)	1.70083221
93	Nasal polyposis (HP:0100582)	1.69970950
94	High pitched voice (HP:0001620)	1.65977184
95	Congenital stationary night blindness (HP:0007642)	1.64931680
96	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.64547371
97	Gaze-evoked nystagmus (HP:0000640)	1.64091797
98	Chronic hepatic failure (HP:0100626)	1.63057627
99	Attenuation of retinal blood vessels (HP:0007843)	1.62749298
100	Abnormality of the preputium (HP:0100587)	1.60293454

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	5.76788151
2	TLK1	3.68006118
3	ZAK	3.51433259
4	LATS1	2.61619554
5	RPS6KA5	2.57685902
6	NEK2	2.53480831
7	MYLK	2.44622836
8	BMPR1B	2.17890032
9	FRK	2.02298316
10	PINK1	10.7864632
11	ACVR1B	1.43869093
12	BRSK2	1.43498587
13	STK38L	1.41533351
14	STK38	1.41432611
15	CDK3	1.21372137
16	CLK1	1.12483639
17	PLK4	1.12464998
18	MAP2K7	1.10859864
19	PRKCQ	1.02185587
20	EIF2AK3	0.98618919
21	MAP3K13	0.96335367
22	MELK	0.93669888
23	MAP3K9	0.92311652
24	LATS2	0.92260514
25	STK24	0.91984201
26	INSRR	0.89310035
27	MST1R	0.88648628
28	SGK223	0.87822507
29	SGK494	0.87822507
30	CSNK1A1L	0.85563198
31	MAPK15	0.81240436
32	TGFBR1	0.80811859
33	AKT3	0.76346773
34	EEF2K	0.70979761
35	ILK	0.70283462
36	OBSCN	0.67130025
37	DYRK3	0.66758491
38	CAMKK2	0.64066805
39	CSNK1G3	0.62275150
40	TAOK3	0.59874490
41	PTK2B	0.57763604
42	WNK3	0.56694793
43	STK3	0.55712115
44	NME2	0.55335534
45	ADRBK2	0.55331034
46	ATM	0.53480172
47	PKN1	0.51336803
48	CDK14	0.50347740
49	RPS6KB1	0.50248337
50	CSNK1G1	0.50182258
51	TIE1	0.50063778
52	GRK1	0.48842735
53	PAK2	0.47160449
54	CSNK1G2	0.45151082
55	MAPKAPK3	0.44361399
56	PAK1	0.43551549
57	MAP3K1	0.41685348
58	MAP3K5	0.41405944
59	TNK2	0.41203190
60	FGFR2	0.40318677
61	PRKG2	0.39728396
62	WEE1	0.39294398
63	PIK3CG	0.38543725
64	VRK1	0.38249352
65	CDC42BPA	0.37995220
66	SGK2	0.37700426
67	FGR	0.36833650
68	ICK	0.36194746
69	CAMK1	0.35857262
70	NTRK3	0.34847430
71	EGFR	0.34844224
72	RET	0.33615898
73	AURKB	0.33226387
74	MST4	0.32706130
75	MTOR	0.32653992
76	CAMK1D	0.32583653
77	PLK1	0.31515795
78	ROCK1	0.30415062
79	ATR	0.28641695
80	CDC7	0.28165334
81	RPS6KB2	0.26806745
82	CAMK1G	0.26685431
83	MAP2K1	0.26587123
84	RPS6KA3	0.24831110
85	CDK5	0.23278614
86	CSNK1A1	0.23151186
87	BTK	0.22967228
88	PRKAA1	0.22382659
89	PDPK1	0.21933875
90	RPS6KA4	0.21837745
91	PIM1	0.21789880
92	BRSK1	0.20728129
93	CSNK1E	0.20396335
94	CSNK1D	0.19862480
95	MAP3K2	0.19470895
96	TNIK	0.19287206
97	MAP3K7	0.19011229
98	DYRK2	0.18973563
99	MET	0.18836317
100	MAPK1	0.17977015

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	6.38600284
2	Gap junction_Homo sapiens_hsa04540	4.30216920
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.74206940
4	Olfactory transduction_Homo sapiens_hsa04740	3.33293916
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.97914189
6	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.68208271
7	Apoptosis_Homo sapiens_hsa04210	2.38337118
8	Butanoate metabolism_Homo sapiens_hsa00650	2.30574535
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.29322145
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.27554509
11	Propanoate metabolism_Homo sapiens_hsa00640	2.04716466
12	Phagosome_Homo sapiens_hsa04145	2.02543963
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.00947253
14	Alcoholism_Homo sapiens_hsa05034	2.00562551
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.79782051
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79298466
17	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.74804963
18	Glutathione metabolism_Homo sapiens_hsa00480	1.67041955
19	Taste transduction_Homo sapiens_hsa04742	1.49669874
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.47955628
21	Pyruvate metabolism_Homo sapiens_hsa00620	1.37540282
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.37434571
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30332913
24	Circadian rhythm_Homo sapiens_hsa04710	1.26767330
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.20139365
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.19091130
27	Phototransduction_Homo sapiens_hsa04744	1.17792210
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.16378607
29	One carbon pool by folate_Homo sapiens_hsa00670	1.12646688
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.11005949
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.10696490
32	Basal transcription factors_Homo sapiens_hsa03022	1.10421520
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.07752193
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.03235994
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00652088
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96884148
37	Oocyte meiosis_Homo sapiens_hsa04114	0.94689858
38	RNA transport_Homo sapiens_hsa03013	0.93373409
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.92238915
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91198751
41	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86284850
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82953482
43	mRNA surveillance pathway_Homo sapiens_hsa03015	0.80993975
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.79960690
45	Glucagon signaling pathway_Homo sapiens_hsa04922	0.77458997
46	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76930276
47	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.74954878
48	Homologous recombination_Homo sapiens_hsa03440	0.73160642
49	RNA degradation_Homo sapiens_hsa03018	0.72359551
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71532596
51	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71348329
52	Purine metabolism_Homo sapiens_hsa00230	0.70911057
53	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69185431
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67800894
55	Nicotine addiction_Homo sapiens_hsa05033	0.67634050
56	Gastric acid secretion_Homo sapiens_hsa04971	0.67280578
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65863450
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.62631554
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.62000752
60	Lysine degradation_Homo sapiens_hsa00310	0.61790095
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59903497
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.59184834
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59110483
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57176922
65	Regulation of autophagy_Homo sapiens_hsa04140	0.56622487
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56181869
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54208126
68	ABC transporters_Homo sapiens_hsa02010	0.52341587
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51251919
70	DNA replication_Homo sapiens_hsa03030	0.49374280
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48463618
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.47761616
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47298015
74	Metabolic pathways_Homo sapiens_hsa01100	0.44078335
75	Renin secretion_Homo sapiens_hsa04924	0.43708136
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42770274
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41449200
78	Retinol metabolism_Homo sapiens_hsa00830	0.39562948
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38884826
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.38651721
81	PPAR signaling pathway_Homo sapiens_hsa03320	0.37517374
82	RNA polymerase_Homo sapiens_hsa03020	0.35579630
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32148210
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.31619933
85	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30812944
86	mTOR signaling pathway_Homo sapiens_hsa04150	0.27259872
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.26649038
88	Cell cycle_Homo sapiens_hsa04110	0.26098154
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.25706739
90	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.23958532
91	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.23719902
92	Peroxisome_Homo sapiens_hsa04146	0.22798900
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22557378
94	Circadian entrainment_Homo sapiens_hsa04713	0.22153481
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.17943039
96	Fatty acid degradation_Homo sapiens_hsa00071	0.17266841
97	Caffeine metabolism_Homo sapiens_hsa00232	0.15904060
98	FoxO signaling pathway_Homo sapiens_hsa04068	0.15689050
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.15135009
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.13148851

NBPF5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »