ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	7.41745417
2	nuclear pore organization (GO:0006999)	6.26861378
3	homocysteine metabolic process (GO:0050667)	5.71940749
4	pore complex assembly (GO:0046931)	5.46544893
5	synapsis (GO:0007129)	5.31541023
6	regulation of translational fidelity (GO:0006450)	5.09987868
7	regulation of histone H3-K27 methylation (GO:0061085)	5.09605982
8	diterpenoid biosynthetic process (GO:0016102)	5.04916645
9	Golgi transport vesicle coating (GO:0048200)	4.92336335
10	COPI coating of Golgi vesicle (GO:0048205)	4.92336335
11	nucleosome disassembly (GO:0006337)	4.91370751
12	protein-DNA complex disassembly (GO:0032986)	4.91370751
13	male meiosis (GO:0007140)	4.54946737
14	DNA replication initiation (GO:0006270)	4.46519363
15	mitotic chromosome condensation (GO:0007076)	4.26999321
16	DNA replication checkpoint (GO:0000076)	4.26534989
17	mitotic nuclear envelope disassembly (GO:0007077)	4.23236398
18	potassium ion export (GO:0071435)	4.20692204
19	regulation of histone H3-K4 methylation (GO:0051569)	4.15308179
20	terpenoid biosynthetic process (GO:0016114)	4.11439369
21	binding of sperm to zona pellucida (GO:0007339)	4.11079108
22	DNA synthesis involved in DNA repair (GO:0000731)	4.10846435
23	mitotic sister chromatid segregation (GO:0000070)	4.10813054
24	DNA unwinding involved in DNA replication (GO:0006268)	4.08843150
25	DNA topological change (GO:0006265)	4.00544757
26	regulation of RNA export from nucleus (GO:0046831)	3.98669422
27	sister chromatid segregation (GO:0000819)	3.95711324
28	TOR signaling (GO:0031929)	3.92814616
29	nuclear envelope disassembly (GO:0051081)	3.88064186
30	membrane disassembly (GO:0030397)	3.88064186
31	protein export from nucleus (GO:0006611)	3.72800751
32	chromosome organization involved in meiosis (GO:0070192)	3.64843784
33	regulation of nucleobase-containing compound transport (GO:0032239)	3.63864956
34	midgut development (GO:0007494)	3.63669833
35	response to vitamin A (GO:0033189)	3.57332107
36	microtubule depolymerization (GO:0007019)	3.51645101
37	DNA strand elongation involved in DNA replication (GO:0006271)	3.50975634
38	chromosome condensation (GO:0030261)	3.49072330
39	proline biosynthetic process (GO:0006561)	3.48939306
40	formation of translation preinitiation complex (GO:0001731)	3.47630331
41	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.43385485
42	DNA strand elongation (GO:0022616)	3.42104524
43	definitive hemopoiesis (GO:0060216)	3.40566934
44	poly(A)+ mRNA export from nucleus (GO:0016973)	3.39106648
45	regulation of centriole replication (GO:0046599)	3.27360876
46	telomere maintenance via semi-conservative replication (GO:0032201)	3.26415675
47	DNA packaging (GO:0006323)	3.26109435
48	resolution of meiotic recombination intermediates (GO:0000712)	3.19983181
49	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.17969911
50	tRNA aminoacylation for protein translation (GO:0006418)	3.16202390
51	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.13655709
52	regulation of mitotic spindle organization (GO:0060236)	3.12095463
53	DNA conformation change (GO:0071103)	3.11034538
54	sperm-egg recognition (GO:0035036)	3.07809891
55	regulation of translational elongation (GO:0006448)	3.07782620
56	folic acid metabolic process (GO:0046655)	3.06733167
57	membrane repolarization during action potential (GO:0086011)	3.06430072
58	folic acid-containing compound biosynthetic process (GO:0009396)	3.05389938
59	erythrocyte maturation (GO:0043249)	3.02473569
60	meiotic chromosome segregation (GO:0045132)	3.02398365
61	ribosome biogenesis (GO:0042254)	3.00381126
62	DNA duplex unwinding (GO:0032508)	2.99259419
63	amino acid activation (GO:0043038)	2.98731325
64	tRNA aminoacylation (GO:0043039)	2.98731325
65	regulation of histone methylation (GO:0031060)	2.97542381
66	regulation of centrosome cycle (GO:0046605)	2.93968635
67	histone H3-K9 demethylation (GO:0033169)	2.91616730
68	ribosome assembly (GO:0042255)	2.89335775
69	mRNA cleavage (GO:0006379)	2.88348273
70	DNA geometric change (GO:0032392)	2.87840109
71	chromosome segregation (GO:0007059)	2.87674653
72	telomere maintenance via recombination (GO:0000722)	2.87471535
73	nuclear envelope organization (GO:0006998)	2.87149818
74	DNA methylation involved in gamete generation (GO:0043046)	2.86840093
75	protein complex localization (GO:0031503)	2.86128573
76	intra-S DNA damage checkpoint (GO:0031573)	2.84741979
77	nucleobase-containing small molecule interconversion (GO:0015949)	2.82756417
78	gas transport (GO:0015669)	2.80978435
79	vesicle coating (GO:0006901)	2.79732051
80	mitotic recombination (GO:0006312)	2.79543463
81	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.78641115
82	protoporphyrinogen IX metabolic process (GO:0046501)	2.77870665
83	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.73091478
84	cellular zinc ion homeostasis (GO:0006882)	2.72161423
85	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.71770696
86	negative regulation of histone methylation (GO:0031061)	2.70714895
87	motile cilium assembly (GO:0044458)	2.70295277
88	glucose 6-phosphate metabolic process (GO:0051156)	2.67904807
89	glutamine family amino acid catabolic process (GO:0009065)	2.67688795
90	regulation of oxidative phosphorylation (GO:0002082)	2.67400708
91	glutamine family amino acid biosynthetic process (GO:0009084)	2.66314947
92	spermatid development (GO:0007286)	2.65338492
93	receptor catabolic process (GO:0032801)	2.65312748
94	face development (GO:0060324)	2.65020874
95	COPII vesicle coating (GO:0048208)	2.63915746
96	IMP biosynthetic process (GO:0006188)	2.63421672
97	mitotic metaphase plate congression (GO:0007080)	2.63179634
98	response to epidermal growth factor (GO:0070849)	2.62858119
99	negative regulation of erythrocyte differentiation (GO:0045647)	2.59669656
100	oxygen transport (GO:0015671)	2.59449250

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.44166231
2	ZNF263_19887448_ChIP-Seq_K562_Human	3.91333680
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.81244537
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.23431475
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.95518539
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.95343956
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.58072739
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.52479477
9	NCOR1_26117541_ChIP-Seq_K562_Human	2.45096960
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.32523631
11	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.27807941
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.25181733
13	XRN2_22483619_ChIP-Seq_HELA_Human	2.24934301
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.21580833
15	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.21015666
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.17890954
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.14945740
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.09108188
19	AR_21909140_ChIP-Seq_LNCAP_Human	2.08332267
20	DCP1A_22483619_ChIP-Seq_HELA_Human	2.04435777
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.00515820
22	KDM5A_27292631_Chip-Seq_BREAST_Human	1.97398201
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96359922
24	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.90188426
25	GATA1_22025678_ChIP-Seq_K562_Human	1.81728575
26	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.80855036
27	GATA1_19941826_ChIP-Seq_K562_Human	1.77743545
28	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.75396477
29	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.68595387
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.64702009
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.61299371
32	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.61043164
33	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.60520786
34	MYC_22102868_ChIP-Seq_BL_Human	1.57957864
35	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.55526773
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.54392781
37	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.53684913
38	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.53059231
39	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.51215200
40	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50489945
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.49669669
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.48488895
43	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.47824846
44	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.44637258
45	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.37505956
46	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.36257646
47	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.35540871
48	RACK7_27058665_Chip-Seq_MCF-7_Human	1.33317101
49	CHD1_26751641_Chip-Seq_LNCaP_Human	1.29813804
50	GATA2_19941826_ChIP-Seq_K562_Human	1.28565032
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.27920823
52	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.25711756
53	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.23048855
54	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.21558435
55	CIITA_25753668_ChIP-Seq_RAJI_Human	1.20656244
56	LXR_22292898_ChIP-Seq_THP-1_Human	1.19564561
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.19497351
58	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19069420
59	SPI1_23127762_ChIP-Seq_K562_Human	1.19032813
60	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18618059
61	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.18394260
62	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.18145100
63	SMC4_20622854_ChIP-Seq_HELA_Human	1.17714752
64	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.17033866
65	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.14534995
66	TFEB_21752829_ChIP-Seq_HELA_Human	1.13441731
67	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.13135040
68	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.12757286
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12536535
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.11559140
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10872123
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09118323
73	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08614992
74	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06701722
75	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06612298
76	P68_20966046_ChIP-Seq_HELA_Human	1.05750803
77	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.05679113
78	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.03884351
79	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.99609685
80	ELF5_23300383_ChIP-Seq_T47D_Human	0.99565651
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99353865
82	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.99230275
83	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.98434274
84	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.96671167
85	VDR_21846776_ChIP-Seq_THP-1_Human	0.96252560
86	MAF_26560356_Chip-Seq_TH2_Human	0.93838757
87	SCL_19346495_ChIP-Seq_HPC-7_Human	0.93773214
88	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.91265313
89	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.90921038
90	ATF3_27146783_Chip-Seq_COLON_Human	0.90202346
91	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89301064
92	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.87138947
93	KDM2B_26808549_Chip-Seq_DND41_Human	0.86287548
94	CREB1_26743006_Chip-Seq_LNCaP_Human	0.86172716
95	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.86003426
96	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.85782116
97	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.84546843
98	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.84191457
99	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83613411
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.83556484

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.93740839
2	MP0003693_abnormal_embryo_hatching	3.73410342
3	MP0004957_abnormal_blastocyst_morpholog	3.32566526
4	MP0008995_early_reproductive_senescence	3.25365236
5	MP0010094_abnormal_chromosome_stability	3.02770251
6	MP0000678_abnormal_parathyroid_gland	2.91637972
7	MP0003111_abnormal_nucleus_morphology	2.87051084
8	MP0009697_abnormal_copulation	2.80242250
9	MP0004147_increased_porphyrin_level	2.78597578
10	MP0008058_abnormal_DNA_repair	2.74850759
11	MP0005451_abnormal_body_composition	2.59255612
12	MP0008932_abnormal_embryonic_tissue	2.34577920
13	MP0010234_abnormal_vibrissa_follicle	2.34494839
14	MP0003315_abnormal_perineum_morphology	2.26303727
15	MP0003077_abnormal_cell_cycle	2.26033646
16	MP0004233_abnormal_muscle_weight	2.25503472
17	MP0008057_abnormal_DNA_replication	2.19353158
18	MP0005083_abnormal_biliary_tract	2.18298120
19	MP0003786_premature_aging	1.93077530
20	MP0001929_abnormal_gametogenesis	1.92862520
21	MP0004264_abnormal_extraembryonic_tissu	1.87159592
22	MP0005058_abnormal_lysosome_morphology	1.80005785
23	MP0003718_maternal_effect	1.79489162
24	MP0002132_abnormal_respiratory_system	1.76326768
25	MP0008007_abnormal_cellular_replicative	1.71241519
26	MP0002009_preneoplasia	1.71215457
27	MP0003698_abnormal_male_reproductive	1.70308564
28	MP0003656_abnormal_erythrocyte_physiolo	1.69544994
29	MP0002160_abnormal_reproductive_system	1.65820059
30	MP0002877_abnormal_melanocyte_morpholog	1.64604341
31	MP0001661_extended_life_span	1.58566298
32	MP0002210_abnormal_sex_determination	1.56055544
33	MP0005076_abnormal_cell_differentiation	1.52290168
34	MP0001730_embryonic_growth_arrest	1.52082025
35	MP0001697_abnormal_embryo_size	1.50125311
36	MP0002080_prenatal_lethality	1.49377814
37	MP0010307_abnormal_tumor_latency	1.41139452
38	MP0000350_abnormal_cell_proliferation	1.40522764
39	MP0005380_embryogenesis_phenotype	1.39501956
40	MP0001672_abnormal_embryogenesis/_devel	1.39501956
41	MP0002086_abnormal_extraembryonic_tissu	1.39005100
42	MP0006036_abnormal_mitochondrial_physio	1.38154307
43	MP0008004_abnormal_stomach_pH	1.38010836
44	MP0003984_embryonic_growth_retardation	1.33792457
45	MP0003705_abnormal_hypodermis_morpholog	1.31157161
46	MP0002088_abnormal_embryonic_growth/wei	1.30680098
47	MP0005360_urolithiasis	1.29680663
48	MP0002249_abnormal_larynx_morphology	1.27955988
49	MP0006035_abnormal_mitochondrial_morpho	1.26216424
50	MP0005647_abnormal_sex_gland	1.22339089
51	MP0002396_abnormal_hematopoietic_system	1.19032213
52	MP0000313_abnormal_cell_death	1.16110133
53	MP0005409_darkened_coat_color	1.15974388
54	MP0001145_abnormal_male_reproductive	1.15847659
55	MP0002161_abnormal_fertility/fecundity	1.12434100
56	MP0000681_abnormal_thyroid_gland	1.11333307
57	MP0001727_abnormal_embryo_implantation	1.04108964
58	MP0000653_abnormal_sex_gland	1.04092084
59	MP0002085_abnormal_embryonic_tissue	1.03015799
60	MP0003385_abnormal_body_wall	1.02464217
61	MP0004808_abnormal_hematopoietic_stem	1.01977782
62	MP0005501_abnormal_skin_physiology	1.00028310
63	MP0003942_abnormal_urinary_system	0.99902836
64	MP0002084_abnormal_developmental_patter	0.99343688
65	MP0004381_abnormal_hair_follicle	0.98594101
66	MP0005646_abnormal_pituitary_gland	0.93797054
67	MP0001545_abnormal_hematopoietic_system	0.93349443
68	MP0005397_hematopoietic_system_phenotyp	0.93349443
69	MP0004782_abnormal_surfactant_physiolog	0.92739997
70	MP0002796_impaired_skin_barrier	0.92177271
71	MP0001881_abnormal_mammary_gland	0.90654190
72	MP0000358_abnormal_cell_content/	0.90625705
73	MP0004084_abnormal_cardiac_muscle	0.89280623
74	MP0000537_abnormal_urethra_morphology	0.88727996
75	MP0009931_abnormal_skin_appearance	0.88134195
76	MP0002822_catalepsy	0.88099234
77	MP0001873_stomach_inflammation	0.87992323
78	MP0001664_abnormal_digestion	0.84873199
79	MP0008775_abnormal_heart_ventricle	0.84495844
80	MP0010678_abnormal_skin_adnexa	0.83819261
81	MP0003938_abnormal_ear_development	0.83692506
82	MP0009672_abnormal_birth_weight	0.82479163
83	MP0000383_abnormal_hair_follicle	0.81864395
84	MP0000747_muscle_weakness	0.81090013
85	MP0002269_muscular_atrophy	0.79841475
86	MP0003045_fibrosis	0.78834247
87	MP0006138_congestive_heart_failure	0.78706474
88	MP0010630_abnormal_cardiac_muscle	0.77897316
89	MP0003699_abnormal_female_reproductive	0.75826456
90	MP0004145_abnormal_muscle_electrophysio	0.74848820
91	MP0000462_abnormal_digestive_system	0.73957017
92	MP0009115_abnormal_fat_cell	0.72396762
93	MP0003936_abnormal_reproductive_system	0.72069991
94	MP0003959_abnormal_lean_body	0.71626558
95	MP0000003_abnormal_adipose_tissue	0.71343609
96	MP0000490_abnormal_crypts_of	0.69072394
97	MP0002019_abnormal_tumor_incidence	0.68492138
98	MP0002970_abnormal_white_adipose	0.68218092
99	MP0004197_abnormal_fetal_growth/weight/	0.67725369
100	MP0000428_abnormal_craniofacial_morphol	0.67626905

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal gallbladder physiology (HP:0012438)	5.64230275
2	Cholecystitis (HP:0001082)	5.64230275
3	Reticulocytosis (HP:0001923)	4.93943429
4	Truncus arteriosus (HP:0001660)	4.93215035
5	Ankyloglossia (HP:0010296)	4.63144521
6	Hyperthyroidism (HP:0000836)	4.59327478
7	Chromsome breakage (HP:0040012)	4.23276241
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.14115343
9	Abnormality of reticulocytes (HP:0004312)	3.99051327
10	Bowel incontinence (HP:0002607)	3.45374261
11	Abnormality of oral frenula (HP:0000190)	3.44822428
12	Hypoparathyroidism (HP:0000829)	3.33008468
13	Abnormal large intestine physiology (HP:0012700)	3.28338189
14	Polycythemia (HP:0001901)	3.24015232
15	Birth length less than 3rd percentile (HP:0003561)	3.19598711
16	Seborrheic dermatitis (HP:0001051)	3.08840999
17	Ileus (HP:0002595)	2.93705814
18	Abnormality of homocysteine metabolism (HP:0010919)	2.88865195
19	Homocystinuria (HP:0002156)	2.88865195
20	Hypoplasia of the uterus (HP:0000013)	2.88665700
21	Cerebellar dysplasia (HP:0007033)	2.85305148
22	Abnormality of the tricuspid valve (HP:0001702)	2.84160252
23	Atelectasis (HP:0100750)	2.72477456
24	Septate vagina (HP:0001153)	2.71785779
25	Duplicated collecting system (HP:0000081)	2.67494411
26	Cholelithiasis (HP:0001081)	2.64707128
27	Abnormality of cochlea (HP:0000375)	2.64138659
28	Ventricular fibrillation (HP:0001663)	2.61406598
29	Nonimmune hydrops fetalis (HP:0001790)	2.57223458
30	Insidious onset (HP:0003587)	2.54187443
31	Termporal pattern (HP:0011008)	2.54187443
32	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.53050211
33	Hypertensive crisis (HP:0100735)	2.52920235
34	Sparse lateral eyebrow (HP:0005338)	2.50150783
35	Patellar dislocation (HP:0002999)	2.47768469
36	Orthostatic hypotension (HP:0001278)	2.43583087
37	Abnormality of the preputium (HP:0100587)	2.43345839
38	Sandal gap (HP:0001852)	2.43070253
39	Acute myeloid leukemia (HP:0004808)	2.43021121
40	Self-mutilation (HP:0000742)	2.40745490
41	Resting tremor (HP:0002322)	2.34982922
42	Abnormal hemoglobin (HP:0011902)	2.34901162
43	Colitis (HP:0002583)	2.34387084
44	Ureteral duplication (HP:0000073)	2.32245535
45	Overlapping toe (HP:0001845)	2.31695735
46	Abnormality of DNA repair (HP:0003254)	2.28993946
47	Upper limb muscle weakness (HP:0003484)	2.28750831
48	Abnormally folded helix (HP:0008544)	2.28517806
49	Dysmetric saccades (HP:0000641)	2.28081778
50	Flat cornea (HP:0007720)	2.26712450
51	Male infertility (HP:0003251)	2.24793787
52	Abnormality of glycolysis (HP:0004366)	2.23196660
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.22658526
54	Poikilocytosis (HP:0004447)	2.21082996
55	Abnormal gallbladder morphology (HP:0012437)	2.19025260
56	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.15619489
57	Abnormality of chromosome stability (HP:0003220)	2.12794313
58	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.12792349
59	Cortical dysplasia (HP:0002539)	2.11391325
60	J-shaped sella turcica (HP:0002680)	2.10562182
61	Abnormality of the renal collecting system (HP:0004742)	2.10295912
62	Facial hemangioma (HP:0000329)	2.09811968
63	Abnormality of the carotid arteries (HP:0005344)	2.09569665
64	Squamous cell carcinoma (HP:0002860)	2.09120298
65	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.08255957
66	Relative macrocephaly (HP:0004482)	2.07731210
67	Increased nuchal translucency (HP:0010880)	2.04840096
68	Myelodysplasia (HP:0002863)	2.04060389
69	Acanthocytosis (HP:0001927)	2.03648876
70	Reticulocytopenia (HP:0001896)	1.98723556
71	Duodenal stenosis (HP:0100867)	1.98335802
72	Small intestinal stenosis (HP:0012848)	1.98335802
73	Abnormality of the columella (HP:0009929)	1.98087386
74	Deep philtrum (HP:0002002)	1.97917845
75	Asymmetry of the thorax (HP:0001555)	1.97774998
76	Progressive muscle weakness (HP:0003323)	1.97517882
77	Sex reversal (HP:0012245)	1.97390798
78	Abnormal sex determination (HP:0012244)	1.97390798
79	Gonadal dysgenesis (HP:0000133)	1.96777965
80	Increased connective tissue (HP:0009025)	1.96298738
81	Cutaneous melanoma (HP:0012056)	1.95492769
82	Pallor (HP:0000980)	1.94987898
83	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.94908318
84	Pheochromocytoma (HP:0002666)	1.94811822
85	Insomnia (HP:0100785)	1.94174621
86	Abnormality of the ileum (HP:0001549)	1.93842311
87	Overfolded helix (HP:0000396)	1.93001582
88	Premature ovarian failure (HP:0008209)	1.92626112
89	Meckel diverticulum (HP:0002245)	1.91233042
90	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.89738968
91	Germ cell neoplasia (HP:0100728)	1.88431830
92	Cafe-au-lait spot (HP:0000957)	1.88421973
93	Hyperacusis (HP:0010780)	1.85618380
94	Increased serum pyruvate (HP:0003542)	1.85408034
95	Pili torti (HP:0003777)	1.85143502
96	Hyperbilirubinemia (HP:0002904)	1.81539112
97	Capillary hemangiomas (HP:0005306)	1.80824611
98	Morphological abnormality of the inner ear (HP:0011390)	1.78577132
99	Attention deficit hyperactivity disorder (HP:0007018)	1.77704766
100	Hypergonadotropic hypogonadism (HP:0000815)	1.76901113

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.56127296
2	SCYL2	3.40789180
3	MARK3	3.04243380
4	EIF2AK1	3.02515933
5	EEF2K	2.98514436
6	TTK	2.74124362
7	NME2	2.72917514
8	KSR2	2.66563763
9	CLK1	2.64486848
10	MST1R	2.63023573
11	TRIB3	2.27156444
12	PLK4	2.26114085
13	RIPK4	2.16383453
14	NEK2	2.12848790
15	ICK	2.06997919
16	ZAK	1.99783089
17	BRSK2	1.93413674
18	CDK12	1.83911348
19	NME1	1.81132836
20	MAP3K2	1.80252548
21	RPS6KB2	1.79413210
22	PBK	1.73244342
23	IRAK3	1.70600859
24	WEE1	1.69261726
25	NEK1	1.68463038
26	RAF1	1.60687114
27	SRPK1	1.58931534
28	BMPR2	1.55221687
29	TSSK6	1.49355806
30	BMX	1.49025601
31	CDC7	1.41461648
32	RPS6KA5	1.35524178
33	TLK1	1.34812256
34	MAP3K8	1.29041600
35	NTRK3	1.23986462
36	WNK4	1.22888161
37	CCNB1	1.21252499
38	RET	1.12825675
39	KSR1	1.08777783
40	MET	1.03365673
41	MTOR	1.01604211
42	PKN2	1.00393199
43	CHEK2	0.99178536
44	NEK6	0.98282578
45	PDK2	0.98175731
46	MAP2K1	0.94819671
47	EIF2AK3	0.93985262
48	BUB1	0.93883758
49	MUSK	0.90737129
50	LATS2	0.90566162
51	MAP3K1	0.89181151
52	CDK7	0.89119171
53	BRSK1	0.86831014
54	SIK1	0.86315213
55	YES1	0.85519174
56	ATR	0.83663408
57	PAK1	0.75499401
58	CHEK1	0.74398298
59	AURKB	0.72826841
60	MAPKAPK3	0.70735758
61	ILK	0.70392580
62	PRKG2	0.69085943
63	CDK1	0.65899714
64	AKT2	0.65420452
65	LATS1	0.65373577
66	PLK1	0.63664467
67	ATM	0.58907108
68	RPS6KB1	0.58683452
69	PTK6	0.58678717
70	MAPKAPK5	0.58067516
71	CDK2	0.57873530
72	ALK	0.55746860
73	RPS6KA4	0.54496741
74	BRAF	0.51731271
75	FGFR4	0.51293506
76	MYLK	0.51161496
77	DYRK3	0.49688711
78	MKNK1	0.49181920
79	STK4	0.48679396
80	MST4	0.45847249
81	CDK3	0.45769087
82	JAK2	0.42482860
83	MAP3K10	0.42262845
84	LRRK2	0.41651680
85	STK3	0.40451799
86	BRD4	0.40298305
87	PLK3	0.38858568
88	PRPF4B	0.36735122
89	STK10	0.35413351
90	PDPK1	0.34387444
91	PAK4	0.34121103
92	CSNK1E	0.33642683
93	PASK	0.32264936
94	CSNK2A2	0.30679668
95	AURKA	0.30302776
96	SMG1	0.29986495
97	INSRR	0.29982382
98	WNK1	0.29723555
99	CDK14	0.29678135
100	TRPM7	0.28989443

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.65380968
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.44069796
3	DNA replication_Homo sapiens_hsa03030	3.10489587
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.00913734
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.61914673
6	RNA transport_Homo sapiens_hsa03013	2.48064527
7	One carbon pool by folate_Homo sapiens_hsa00670	2.37556267
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.21302205
9	Mismatch repair_Homo sapiens_hsa03430	2.06489170
10	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.99033342
11	Spliceosome_Homo sapiens_hsa03040	1.97077559
12	Thyroid cancer_Homo sapiens_hsa05216	1.96716669
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.88205642
14	Cell cycle_Homo sapiens_hsa04110	1.86824707
15	Homologous recombination_Homo sapiens_hsa03440	1.77482248
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.75417956
17	Pyruvate metabolism_Homo sapiens_hsa00620	1.75055921
18	Gap junction_Homo sapiens_hsa04540	1.74758567
19	mRNA surveillance pathway_Homo sapiens_hsa03015	1.70925210
20	Carbon metabolism_Homo sapiens_hsa01200	1.62686148
21	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.62439342
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.61989507
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59313200
24	Pentose phosphate pathway_Homo sapiens_hsa00030	1.57139734
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.55961197
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.55825605
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.55667254
28	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.47319618
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.43210141
30	Basal transcription factors_Homo sapiens_hsa03022	1.38739782
31	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.37244593
32	Apoptosis_Homo sapiens_hsa04210	1.36135858
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.34630896
34	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.23074961
35	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.20102550
36	Olfactory transduction_Homo sapiens_hsa04740	1.15950692
37	Oocyte meiosis_Homo sapiens_hsa04114	1.08890494
38	mTOR signaling pathway_Homo sapiens_hsa04150	1.08579409
39	Other glycan degradation_Homo sapiens_hsa00511	1.07703742
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04351929
41	VEGF signaling pathway_Homo sapiens_hsa04370	1.02397250
42	Base excision repair_Homo sapiens_hsa03410	1.01609634
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.00405395
44	Non-small cell lung cancer_Homo sapiens_hsa05223	1.00011979
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.96952266
46	Purine metabolism_Homo sapiens_hsa00230	0.96449359
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92724728
48	Insulin signaling pathway_Homo sapiens_hsa04910	0.92460776
49	Endometrial cancer_Homo sapiens_hsa05213	0.92032323
50	Propanoate metabolism_Homo sapiens_hsa00640	0.89622719
51	Glutathione metabolism_Homo sapiens_hsa00480	0.85577800
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81058486
53	Alcoholism_Homo sapiens_hsa05034	0.79523881
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.79202225
55	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77609164
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.77001299
57	Viral carcinogenesis_Homo sapiens_hsa05203	0.75885146
58	Ribosome_Homo sapiens_hsa03010	0.75480881
59	Lysine degradation_Homo sapiens_hsa00310	0.74252943
60	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.72259458
61	RNA degradation_Homo sapiens_hsa03018	0.71099141
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.70901508
63	RNA polymerase_Homo sapiens_hsa03020	0.70900056
64	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.70181607
65	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.69305284
66	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69050302
67	Pancreatic cancer_Homo sapiens_hsa05212	0.65329623
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64491133
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.62964478
70	Sulfur relay system_Homo sapiens_hsa04122	0.59949112
71	Prostate cancer_Homo sapiens_hsa05215	0.59003523
72	Bladder cancer_Homo sapiens_hsa05219	0.54989662
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54502765
74	Renal cell carcinoma_Homo sapiens_hsa05211	0.49708226
75	Butanoate metabolism_Homo sapiens_hsa00650	0.49552073
76	AMPK signaling pathway_Homo sapiens_hsa04152	0.49218565
77	Glioma_Homo sapiens_hsa05214	0.49171553
78	Galactose metabolism_Homo sapiens_hsa00052	0.48461564
79	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.47134052
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46993915
81	Prolactin signaling pathway_Homo sapiens_hsa04917	0.46500750
82	Choline metabolism in cancer_Homo sapiens_hsa05231	0.46208536
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.45799804
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44311941
85	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.44245086
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43192794
87	Small cell lung cancer_Homo sapiens_hsa05222	0.43013230
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.40821948
89	Insulin resistance_Homo sapiens_hsa04931	0.40524004
90	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.38701750
91	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.37187160
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.37093457
93	Melanoma_Homo sapiens_hsa05218	0.34950219
94	Estrogen signaling pathway_Homo sapiens_hsa04915	0.34606871
95	Hepatitis B_Homo sapiens_hsa05161	0.33430912
96	Proteasome_Homo sapiens_hsa03050	0.32934530
97	Adherens junction_Homo sapiens_hsa04520	0.30780190
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.29663860
99	Metabolic pathways_Homo sapiens_hsa01100	0.29382599
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.23311793

NBPF6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »