NBPF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.15906046
2negative regulation of stress fiber assembly (GO:0051497)6.08881627
3negative regulation of actin filament bundle assembly (GO:0032232)5.29030361
4positive regulation of interleukin-8 secretion (GO:2000484)4.66204611
5positive regulation of protein homodimerization activity (GO:0090073)4.31096288
6regulation of T cell chemotaxis (GO:0010819)4.25669273
7positive regulation of T cell chemotaxis (GO:0010820)4.25669273
8positive regulation of phosphatase activity (GO:0010922)4.24176166
9lymphocyte chemotaxis (GO:0048247)4.21178023
10positive regulation of uterine smooth muscle contraction (GO:0070474)4.13405728
11positive regulation of cAMP-mediated signaling (GO:0043950)4.07972432
12positive regulation of gamma-delta T cell activation (GO:0046645)4.05421269
13T cell migration (GO:0072678)4.04321227
14mature B cell differentiation involved in immune response (GO:0002313)4.00004343
15DNA deamination (GO:0045006)3.95669953
16positive regulation of monocyte chemotaxis (GO:0090026)3.91265792
17positive regulation of chemokine biosynthetic process (GO:0045080)3.76176619
18positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.73918839
19interferon-gamma production (GO:0032609)3.72055527
20regulation of chemokine biosynthetic process (GO:0045073)3.67498517
21cellular response to toxic substance (GO:0097237)3.59447619
22regulation of inositol phosphate biosynthetic process (GO:0010919)3.57275831
23thrombin receptor signaling pathway (GO:0070493)3.56157375
24positive regulation of T cell migration (GO:2000406)3.55288710
25regulation of T cell migration (GO:2000404)3.52970046
26regulation of integrin activation (GO:0033623)3.48370765
27positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.45349052
28positive regulation of dephosphorylation (GO:0035306)3.43796223
29negative regulation of Rho protein signal transduction (GO:0035024)3.37243437
30positive regulation of defense response to virus by host (GO:0002230)3.36802386
31positive regulation of lymphocyte migration (GO:2000403)3.35594076
32positive regulation of protein kinase C signaling (GO:0090037)3.33706674
33negative regulation by host of viral transcription (GO:0043922)3.25442261
34cellular response to antibiotic (GO:0071236)3.24803086
35Notch signaling involved in heart development (GO:0061314)3.23571953
36regulation of alkaline phosphatase activity (GO:0010692)3.21329497
37negative regulation of nitric oxide biosynthetic process (GO:0045019)3.19028339
38regulation of gamma-delta T cell differentiation (GO:0045586)3.18496707
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16631007
40regulation of lymphocyte chemotaxis (GO:1901623)3.14780453
41regulation of interleukin-8 secretion (GO:2000482)3.14555617
42positive regulation of smooth muscle cell migration (GO:0014911)3.12224823
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11852021
44positive regulation of heat generation (GO:0031652)3.09209495
45regulation of regulatory T cell differentiation (GO:0045589)3.08639869
46positive regulation of interferon-beta production (GO:0032728)3.08119355
47chemokine-mediated signaling pathway (GO:0070098)3.07361539
48regulation of vitamin D biosynthetic process (GO:0060556)3.02674168
49regulation of gamma-delta T cell activation (GO:0046643)3.02652822
50regulation of cytokine secretion involved in immune response (GO:0002739)3.01374254
51adaptation of signaling pathway (GO:0023058)2.97715911
52virion attachment to host cell (GO:0019062)2.97648951
53adhesion of symbiont to host cell (GO:0044650)2.97648951
54regulation of chronic inflammatory response (GO:0002676)2.95427426
55cytidine metabolic process (GO:0046087)2.90634103
56cytidine catabolic process (GO:0006216)2.90634103
57cytidine deamination (GO:0009972)2.90634103
58regulation of sarcomere organization (GO:0060297)2.89062578
59positive regulation of calcium ion transport into cytosol (GO:0010524)2.89029941
60negative regulation of smooth muscle cell migration (GO:0014912)2.88759893
61cGMP-mediated signaling (GO:0019934)2.87801919
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86596341
63positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.86197163
64TOR signaling (GO:0031929)2.84502841
65regulation of monocyte chemotaxis (GO:0090025)2.81576605
66regulation of uterine smooth muscle contraction (GO:0070472)2.81296464
67regulation of vitamin metabolic process (GO:0030656)2.80392071
68regulation of megakaryocyte differentiation (GO:0045652)2.80247997
69negative regulation of execution phase of apoptosis (GO:1900118)2.72191476
70positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.71835711
71positive regulation of translational initiation (GO:0045948)2.70702202
72positive regulation of leukocyte apoptotic process (GO:2000108)2.70492755
73protein polyglutamylation (GO:0018095)2.70394983
74positive regulation of smooth muscle contraction (GO:0045987)2.70314683
75dendritic cell chemotaxis (GO:0002407)2.68285417
76cellular extravasation (GO:0045123)2.65738466
77ventricular system development (GO:0021591)2.63361116
78regulation of lymphocyte migration (GO:2000401)2.61767726
79negative regulation of viral transcription (GO:0032897)2.59372923
80pyrimidine ribonucleoside catabolic process (GO:0046133)2.55889175
81positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55540973
82cGMP biosynthetic process (GO:0006182)2.55430700
83positive regulation of mRNA catabolic process (GO:0061014)2.55347468
84negative regulation of viral genome replication (GO:0045071)2.55007649
85positive regulation of lamellipodium assembly (GO:0010592)2.54990381
86regulation of G0 to G1 transition (GO:0070316)2.54113963
87mature B cell differentiation (GO:0002335)2.53540192
88eosinophil chemotaxis (GO:0048245)2.53398829
89cellular response to exogenous dsRNA (GO:0071360)2.53050643
90activation of protein kinase B activity (GO:0032148)2.52653663
91base-excision repair, AP site formation (GO:0006285)2.51282478
92regulation of interferon-alpha production (GO:0032647)2.50135053
93positive regulation of interleukin-6 production (GO:0032755)2.49671474
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47168008
95regulation of execution phase of apoptosis (GO:1900117)2.46703179
96dentate gyrus development (GO:0021542)2.45071804
97lateral sprouting from an epithelium (GO:0060601)2.44633916
98muscle cell cellular homeostasis (GO:0046716)2.44535057
99regulation of germinal center formation (GO:0002634)2.43791356
100positive regulation of fatty acid transport (GO:2000193)2.43640494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.57217225
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.64025360
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.30581051
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.10715734
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81326962
6GATA1_22025678_ChIP-Seq_K562_Human3.64083226
7GBX2_23144817_ChIP-Seq_PC3_Human3.11266184
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.88403820
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.71776552
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57085171
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28370071
12VDR_22108803_ChIP-Seq_LS180_Human2.18360271
13ER_23166858_ChIP-Seq_MCF-7_Human2.00929551
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.93414716
15IGF1R_20145208_ChIP-Seq_DFB_Human1.85611942
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81931699
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77158396
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73179280
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62693534
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62054801
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60068176
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59938970
23GATA3_26560356_Chip-Seq_TH2_Human1.57431954
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56005482
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53649476
26GATA3_27048872_Chip-Seq_THYMUS_Human1.49895929
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47375699
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44099190
29FUS_26573619_Chip-Seq_HEK293_Human1.41732041
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.41241940
31RUNX_20019798_ChIP-Seq_JUKART_Human1.38587641
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36330209
33MYB_26560356_Chip-Seq_TH2_Human1.36309897
34PRDM14_20953172_ChIP-Seq_ESCs_Human1.33971059
35TAL1_26923725_Chip-Seq_HPCs_Mouse1.33873164
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32836015
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31004196
38SCL_19346495_ChIP-Seq_HPC-7_Human1.30979320
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30867835
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28018666
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27581870
42CBP_20019798_ChIP-Seq_JUKART_Human1.27581870
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27186236
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24845463
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24303871
46RXR_22108803_ChIP-Seq_LS180_Human1.24264416
47BCAT_22108803_ChIP-Seq_LS180_Human1.23247215
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23041959
49P300_19829295_ChIP-Seq_ESCs_Human1.22769931
50VDR_24787735_ChIP-Seq_THP-1_Human1.22615344
51* NANOG_20526341_ChIP-Seq_ESCs_Human1.21012199
52SOX2_19829295_ChIP-Seq_ESCs_Human1.20600880
53NANOG_19829295_ChIP-Seq_ESCs_Human1.20600880
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.20178969
55* CDX2_22108803_ChIP-Seq_LS180_Human1.18806248
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18310530
57* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17683370
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16888048
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14156251
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13594381
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11077993
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10464957
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.10381655
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10234029
65AR_21572438_ChIP-Seq_LNCaP_Human1.07967379
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.06332760
67STAT3_23295773_ChIP-Seq_U87_Human1.06294760
68* NCOR_22424771_ChIP-Seq_293T_Human1.03602987
69* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03022485
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00988420
71TCF4_23295773_ChIP-Seq_U87_Human0.99441510
72AR_20517297_ChIP-Seq_VCAP_Human0.98915519
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96655906
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96622085
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95651821
76* OCT4_20526341_ChIP-Seq_ESCs_Human0.95556437
77STAT1_20625510_ChIP-Seq_HELA_Human0.94071317
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92521308
79HNFA_21074721_ChIP-Seq_CACO-2_Human0.91104005
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89945032
81SMAD4_21799915_ChIP-Seq_A2780_Human0.89897660
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89521287
83ESR1_20079471_ChIP-ChIP_T-47D_Human0.88277214
84SRF_21415370_ChIP-Seq_HL-1_Mouse0.87286865
85* NFYB_21822215_ChIP-Seq_K562_Human0.86444797
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.86184836
87PHF8_20622853_ChIP-Seq_HELA_Human0.84502061
88E2F1_18555785_Chip-Seq_ESCs_Mouse0.83547910
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83545587
90P53_22387025_ChIP-Seq_ESCs_Mouse0.83428918
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83087895
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82097317
93CJUN_26792858_Chip-Seq_BT549_Human0.81719412
94* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81544025
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80915092
96TAF15_26573619_Chip-Seq_HEK293_Human0.80874729
97* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80823484
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80673769
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.80673769
100RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80071872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.55852142
2MP0008004_abnormal_stomach_pH3.54462295
3MP0003724_increased_susceptibility_to3.42440041
4MP0005671_abnormal_response_to3.18840925
5MP0002148_abnormal_hypersensitivity_rea3.10041022
6MP0009785_altered_susceptibility_to2.85547130
7MP0003303_peritoneal_inflammation2.83763366
8MP0003866_abnormal_defecation2.82670212
9MP0001661_extended_life_span2.69037803
10MP0004043_abnormal_pH_regulation2.65995558
11MP0005360_urolithiasis2.52836990
12MP0003045_fibrosis2.37186011
13MP0005670_abnormal_white_adipose2.36171659
14MP0002837_dystrophic_cardiac_calcinosis2.30955727
15MP0010155_abnormal_intestine_physiology2.28889710
16MP0001542_abnormal_bone_strength2.28384527
17MP0006082_CNS_inflammation2.25727107
18MP0002876_abnormal_thyroid_physiology2.17042049
19MP0005166_decreased_susceptibility_to2.07430754
20MP0005058_abnormal_lysosome_morphology2.06025263
21MP0010386_abnormal_urinary_bladder2.04800936
22MP0009333_abnormal_splenocyte_physiolog2.02531631
23MP0005000_abnormal_immune_tolerance1.83946825
24MP0001664_abnormal_digestion1.82451385
25MP0001835_abnormal_antigen_presentation1.75597318
26MP0005025_abnormal_response_to1.73896110
27MP0001800_abnormal_humoral_immune1.73623984
28MP0001501_abnormal_sleep_pattern1.69998569
29MP0000343_altered_response_to1.69809427
30MP0001666_abnormal_nutrient_absorption1.68790099
31MP0000538_abnormal_urinary_bladder1.67127912
32MP0005464_abnormal_platelet_physiology1.61848196
33MP0003136_yellow_coat_color1.61706175
34MP0002723_abnormal_immune_serum1.59514431
35MP0000465_gastrointestinal_hemorrhage1.58535384
36MP0003195_calcinosis1.58454849
37MP0009764_decreased_sensitivity_to1.54767266
38MP0001533_abnormal_skeleton_physiology1.54031171
39MP0003763_abnormal_thymus_physiology1.53869955
40MP0002295_abnormal_pulmonary_circulatio1.47410169
41MP0002693_abnormal_pancreas_physiology1.41007564
42MP0004883_abnormal_blood_vessel1.39874745
43MP0003448_altered_tumor_morphology1.39602310
44MP0008469_abnormal_protein_level1.39515011
45MP0001984_abnormal_olfaction1.37889165
46MP0005075_abnormal_melanosome_morpholog1.36315533
47MP0005410_abnormal_fertilization1.35687194
48MP0005164_abnormal_response_to1.29486911
49MP0005084_abnormal_gallbladder_morpholo1.27965583
50MP0002452_abnormal_antigen_presenting1.25752074
51MP0003806_abnormal_nucleotide_metabolis1.25193739
52MP0001845_abnormal_inflammatory_respons1.24667786
53MP0003436_decreased_susceptibility_to1.24637205
54MP0000383_abnormal_hair_follicle1.23849849
55MP0001849_ear_inflammation1.23109202
56MP0004147_increased_porphyrin_level1.20048177
57MP0009765_abnormal_xenobiotic_induced1.14781928
58MP0004808_abnormal_hematopoietic_stem1.13714568
59MP0002420_abnormal_adaptive_immunity1.13231827
60MP0009643_abnormal_urine_homeostasis1.12997766
61MP0001819_abnormal_immune_cell1.12325417
62MP0003011_delayed_dark_adaptation1.10679303
63MP0005085_abnormal_gallbladder_physiolo1.10534632
64MP0006054_spinal_hemorrhage1.08822348
65MP0005332_abnormal_amino_acid1.08689933
66MP0002332_abnormal_exercise_endurance1.06054347
67MP0000685_abnormal_immune_system1.03103449
68MP0000013_abnormal_adipose_tissue1.01847055
69MP0000230_abnormal_systemic_arterial1.01316141
70MP0003656_abnormal_erythrocyte_physiolo1.00826684
71MP0003279_aneurysm1.00653232
72MP0002136_abnormal_kidney_physiology0.98890808
73MP0002736_abnormal_nociception_after0.98366819
74MP0001790_abnormal_immune_system0.97653111
75MP0005387_immune_system_phenotype0.97653111
76MP0005595_abnormal_vascular_smooth0.97353056
77MP0000703_abnormal_thymus_morphology0.96012139
78MP0004947_skin_inflammation0.95763006
79MP0002722_abnormal_immune_system0.93261384
80MP0000579_abnormal_nail_morphology0.92570980
81MP0010678_abnormal_skin_adnexa0.91471592
82MP0001765_abnormal_ion_homeostasis0.84718629
83MP0002419_abnormal_innate_immunity0.81508638
84MP0000716_abnormal_immune_system0.81392516
85MP0003950_abnormal_plasma_membrane0.80601492
86MP0005389_reproductive_system_phenotype0.79904706
87MP0005266_abnormal_metabolism0.79656461
88MP0002398_abnormal_bone_marrow0.79116752
89MP0002254_reproductive_system_inflammat0.78724610
90MP0004233_abnormal_muscle_weight0.78541469
91MP0000569_abnormal_digit_pigmentation0.77580480
92MP0005376_homeostasis/metabolism_phenot0.77235796
93MP0002160_abnormal_reproductive_system0.77210530
94MP0008775_abnormal_heart_ventricle0.75754554
95MP0005636_abnormal_mineral_homeostasis0.75191518
96MP0002405_respiratory_system_inflammati0.74973190
97MP0003300_gastrointestinal_ulcer0.74942101
98MP0001663_abnormal_digestive_system0.74800428
99MP0005319_abnormal_enzyme/_coenzyme0.73865592
100MP0003879_abnormal_hair_cell0.73539122

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)4.62467526
2Stomatitis (HP:0010280)4.50257290
3Pancreatic fibrosis (HP:0100732)3.81568604
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.71209668
5IgG deficiency (HP:0004315)3.54433683
6Abnormal rod and cone electroretinograms (HP:0008323)3.38368916
7Attenuation of retinal blood vessels (HP:0007843)3.19972869
8Congenital sensorineural hearing impairment (HP:0008527)3.17407026
9Abnormality of the periventricular white matter (HP:0002518)3.10937872
10Abnormality of the costochondral junction (HP:0000919)3.03093040
11Long nose (HP:0003189)2.94449257
12Abolished electroretinogram (ERG) (HP:0000550)2.90558541
13J-shaped sella turcica (HP:0002680)2.90091785
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.83389483
15Absent/shortened dynein arms (HP:0200106)2.83389483
16Retinal dysplasia (HP:0007973)2.80225692
17True hermaphroditism (HP:0010459)2.79045331
18Short middle phalanx of the 5th finger (HP:0004220)2.73940461
19Hypoproteinemia (HP:0003075)2.71650031
20Abnormality of the columella (HP:0009929)2.69700435
21Pulmonary artery stenosis (HP:0004415)2.68559946
22Enlarged epiphyses (HP:0010580)2.67250757
23Pancreatic cysts (HP:0001737)2.63131339
24Widely patent fontanelles and sutures (HP:0004492)2.57438723
25Elevated erythrocyte sedimentation rate (HP:0003565)2.55228196
26Type II lissencephaly (HP:0007260)2.54372543
27Autoimmune hemolytic anemia (HP:0001890)2.52713162
28Cystic liver disease (HP:0006706)2.51413298
29Exercise-induced myalgia (HP:0003738)2.50087928
30Congenital stationary night blindness (HP:0007642)2.45476901
31Thyroiditis (HP:0100646)2.44296888
32Mesomelia (HP:0003027)2.41671410
33B lymphocytopenia (HP:0010976)2.41310420
34Thin bony cortex (HP:0002753)2.38834035
35Palpitations (HP:0001962)2.36372897
36Prolonged neonatal jaundice (HP:0006579)2.35891918
37Abnormality of B cell number (HP:0010975)2.35212558
38Abnormality of lateral ventricle (HP:0030047)2.33041300
39Cutaneous melanoma (HP:0012056)2.31810507
40Hypophosphatemic rickets (HP:0004912)2.31266021
41Constricted visual fields (HP:0001133)2.30572330
42Hypothermia (HP:0002045)2.28691356
43Gaze-evoked nystagmus (HP:0000640)2.26748097
44Autoimmune thrombocytopenia (HP:0001973)2.26489058
45Generalized aminoaciduria (HP:0002909)2.25517832
46Occipital encephalocele (HP:0002085)2.22717694
47CNS hypomyelination (HP:0003429)2.16859356
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.15421428
49Neonatal respiratory distress (HP:0002643)2.12975094
50Retrobulbar optic neuritis (HP:0100654)2.12682822
51Optic neuritis (HP:0100653)2.12682822
52Stomach cancer (HP:0012126)2.12451322
53Anterior segment dysgenesis (HP:0007700)2.12443950
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11443281
55Vacuolated lymphocytes (HP:0001922)2.08483327
56T lymphocytopenia (HP:0005403)2.08116163
57Cerebral hypomyelination (HP:0006808)2.08072309
58Chorioretinal atrophy (HP:0000533)2.07410908
59Bifid tongue (HP:0010297)2.07050673
60Oligodontia (HP:0000677)2.06752646
61Spondylolisthesis (HP:0003302)2.03686295
62Delayed epiphyseal ossification (HP:0002663)2.01613212
63Truncus arteriosus (HP:0001660)1.99858640
64Abnormal protein N-linked glycosylation (HP:0012347)1.98718435
65Abnormal protein glycosylation (HP:0012346)1.98718435
66Abnormal glycosylation (HP:0012345)1.98718435
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98718435
68Anencephaly (HP:0002323)1.98108158
69Clumsiness (HP:0002312)1.97917825
70Hemiplegia (HP:0002301)1.97854234
71Abnormality of transition element cation homeostasis (HP:0011030)1.96990751
72Difficulty walking (HP:0002355)1.95349826
73Medial flaring of the eyebrow (HP:0010747)1.94069460
74Confusion (HP:0001289)1.92547785
75Reduced antithrombin III activity (HP:0001976)1.89612124
76Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88945131
77Exocrine pancreatic insufficiency (HP:0001738)1.88803796
78Hyperthyroidism (HP:0000836)1.88546136
79Buphthalmos (HP:0000557)1.88176964
80Hyperkalemia (HP:0002153)1.85590589
81Recurrent bronchitis (HP:0002837)1.85327924
82Short tibia (HP:0005736)1.84707314
83Genital tract atresia (HP:0001827)1.83762495
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.83497822
85Abnormality of T cell number (HP:0011839)1.83334743
86Abnormality of glycolipid metabolism (HP:0010969)1.82204443
87Abnormality of liposaccharide metabolism (HP:0010968)1.82204443
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.82204443
89Congenital, generalized hypertrichosis (HP:0004540)1.81925543
90Disinhibition (HP:0000734)1.81265277
91Congenital primary aphakia (HP:0007707)1.79031028
92Abnormality of eosinophils (HP:0001879)1.77849218
93Focal segmental glomerulosclerosis (HP:0000097)1.76262442
94Abnormal ciliary motility (HP:0012262)1.75294549
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73757995
96Cerebellar dysplasia (HP:0007033)1.73624818
97Congenital hepatic fibrosis (HP:0002612)1.73525180
98Ureteral duplication (HP:0000073)1.70176349
99Subcapsular cataract (HP:0000523)1.69118646
100Eosinophilia (HP:0001880)1.68901946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF15.15131725
2TXK4.77644384
3PINK14.44864972
4FRK3.92231532
5MAP4K23.12747022
6EPHA32.90922368
7NTRK12.39304573
8TAOK32.38203006
9ADRBK22.31319568
10MAP3K132.00988663
11ITK1.97167979
12MARK31.94398567
13SIK21.92358775
14NEK21.88916215
15WNK41.86789691
16IRAK31.82549238
17ZAP701.78834646
18MST1R1.68680169
19MAP4K11.65282849
20TEC1.61233751
21NME11.58778642
22TESK21.54058222
23MAPK121.52682853
24NTRK21.50542476
25IKBKE1.40647744
26TBK11.35091285
27PLK41.32408921
28PRKG21.31243511
29FGFR21.22430991
30BTK1.21108278
31IKBKB1.19222014
32KSR21.17485497
33EIF2AK31.10777065
34BMPR21.04696135
35MYLK1.04092062
36CDK81.00614170
37TLK10.99389892
38JAK20.96807987
39GRK70.94007749
40GRK60.90262299
41MAPK70.90216977
42DAPK20.89358123
43CCNB10.89199356
44MAPKAPK30.88196569
45TRPM70.83942701
46PHKG20.83612119
47PHKG10.83612119
48DDR20.82726807
49TYK20.80262405
50OBSCN0.77590687
51EPHB10.77317819
52STK390.74685332
53MST40.72860765
54RPS6KA50.71605046
55IRAK10.68270130
56ERBB30.67307267
57MAP3K10.66405563
58PTK2B0.61324928
59HCK0.60399017
60ACVR1B0.60157586
61PRKCQ0.59904743
62IRAK20.59806969
63LCK0.58393626
64LYN0.58379374
65SYK0.49680029
66CAMKK20.43339327
67NTRK30.42491620
68CHUK0.41282109
69FER0.40497143
70PIK3CG0.38801759
71PIK3CA0.38710656
72INSRR0.37897116
73KSR10.37862795
74FGFR30.36954261
75CSK0.36723055
76BCKDK0.36093484
77MOS0.34748549
78PRKD10.34723182
79MAP2K60.34311673
80FGFR40.34271706
81ABL10.32982263
82CSNK1A10.32929552
83IGF1R0.32397468
84OXSR10.31178082
85MUSK0.30482864
86GRK10.29011235
87PRKG10.26134935
88PAK30.25989579
89BUB10.25278627
90VRK10.24412002
91JAK10.24390438
92NLK0.23743715
93MAP3K140.23161529
94WNK10.23141367
95RIPK10.21800392
96TNK20.21755776
97RIPK40.21717944
98CSNK1A1L0.21105916
99NEK60.20621542
100JAK30.20591700

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.60265213
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.57970127
3Sulfur metabolism_Homo sapiens_hsa009203.31829701
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.52911102
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.46700011
6Caffeine metabolism_Homo sapiens_hsa002322.24798217
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07727671
8Salivary secretion_Homo sapiens_hsa049701.99084441
9RNA polymerase_Homo sapiens_hsa030201.98243004
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87463943
11Mineral absorption_Homo sapiens_hsa049781.84815068
12Primary immunodeficiency_Homo sapiens_hsa053401.84284956
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70152568
14ABC transporters_Homo sapiens_hsa020101.58996914
15Olfactory transduction_Homo sapiens_hsa047401.56058308
16Hematopoietic cell lineage_Homo sapiens_hsa046401.53765855
17African trypanosomiasis_Homo sapiens_hsa051431.52675100
18Malaria_Homo sapiens_hsa051441.52070264
19Graft-versus-host disease_Homo sapiens_hsa053321.50096038
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.48226567
21Renin secretion_Homo sapiens_hsa049241.47020117
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46298079
23Rheumatoid arthritis_Homo sapiens_hsa053231.39156323
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37314957
25Linoleic acid metabolism_Homo sapiens_hsa005911.36328195
26Tryptophan metabolism_Homo sapiens_hsa003801.29398399
27Nitrogen metabolism_Homo sapiens_hsa009101.27881234
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.27112122
29Measles_Homo sapiens_hsa051621.23357820
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22281304
31Chemical carcinogenesis_Homo sapiens_hsa052041.19893620
32Allograft rejection_Homo sapiens_hsa053301.13773254
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12929583
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11928201
35TNF signaling pathway_Homo sapiens_hsa046681.11476580
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10532700
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09355849
38Prion diseases_Homo sapiens_hsa050201.04960287
39Calcium signaling pathway_Homo sapiens_hsa040201.04275343
40Retinol metabolism_Homo sapiens_hsa008301.03047682
41Glycerolipid metabolism_Homo sapiens_hsa005611.01661661
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.00534396
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98662683
44Long-term depression_Homo sapiens_hsa047300.98574366
45Salmonella infection_Homo sapiens_hsa051320.97767343
46Autoimmune thyroid disease_Homo sapiens_hsa053200.94924342
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.91944096
48T cell receptor signaling pathway_Homo sapiens_hsa046600.91431618
49Legionellosis_Homo sapiens_hsa051340.90838416
50Fatty acid biosynthesis_Homo sapiens_hsa000610.89632818
51Type I diabetes mellitus_Homo sapiens_hsa049400.88992421
52Propanoate metabolism_Homo sapiens_hsa006400.88912200
53Platelet activation_Homo sapiens_hsa046110.87011679
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.85041663
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84955265
56Antigen processing and presentation_Homo sapiens_hsa046120.84515490
57Renin-angiotensin system_Homo sapiens_hsa046140.84180386
58Gap junction_Homo sapiens_hsa045400.83144310
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81247160
60Chemokine signaling pathway_Homo sapiens_hsa040620.80637371
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77795435
62Purine metabolism_Homo sapiens_hsa002300.77208479
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75916404
64Taste transduction_Homo sapiens_hsa047420.74372935
65Sulfur relay system_Homo sapiens_hsa041220.73451707
66Staphylococcus aureus infection_Homo sapiens_hsa051500.72475060
67Inositol phosphate metabolism_Homo sapiens_hsa005620.68571932
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68125385
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.66577576
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64307085
71Circadian entrainment_Homo sapiens_hsa047130.64262500
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61120963
73Pertussis_Homo sapiens_hsa051330.60103282
74Basal transcription factors_Homo sapiens_hsa030220.59944273
75Influenza A_Homo sapiens_hsa051640.59656489
76Osteoclast differentiation_Homo sapiens_hsa043800.57606075
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55737814
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.54832405
79Peroxisome_Homo sapiens_hsa041460.53806208
80Insulin secretion_Homo sapiens_hsa049110.51634387
81Fat digestion and absorption_Homo sapiens_hsa049750.51391823
82Homologous recombination_Homo sapiens_hsa034400.50988758
83Type II diabetes mellitus_Homo sapiens_hsa049300.50864442
84Arachidonic acid metabolism_Homo sapiens_hsa005900.50612305
85Serotonergic synapse_Homo sapiens_hsa047260.49865314
86Thyroid hormone synthesis_Homo sapiens_hsa049180.48681976
87Pancreatic secretion_Homo sapiens_hsa049720.47825101
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.47312334
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47121325
90Asthma_Homo sapiens_hsa053100.46005641
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45840027
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43170048
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.41850880
94Ether lipid metabolism_Homo sapiens_hsa005650.41273379
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40304368
96Lysosome_Homo sapiens_hsa041420.40234640
97Insulin resistance_Homo sapiens_hsa049310.39503356
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.39202953
99Ovarian steroidogenesis_Homo sapiens_hsa049130.39191518
100Choline metabolism in cancer_Homo sapiens_hsa052310.37102634

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