NBR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)5.78884093
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.67855754
3protein complex biogenesis (GO:0070271)4.62627382
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.54895305
5NADH dehydrogenase complex assembly (GO:0010257)4.54895305
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.54895305
7regulation of telomere maintenance via telomerase (GO:0032210)4.43434345
8behavioral response to nicotine (GO:0035095)4.24215964
9mitochondrial respiratory chain complex assembly (GO:0033108)4.22186912
10response to pheromone (GO:0019236)4.06483415
11protein polyglutamylation (GO:0018095)3.97208423
12regulation of telomere maintenance (GO:0032204)3.88132015
13water-soluble vitamin biosynthetic process (GO:0042364)3.71397313
14negative regulation of telomerase activity (GO:0051974)3.66847198
15DNA damage induced protein phosphorylation (GO:0006975)3.54724703
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53698650
17epithelial cilium movement (GO:0003351)3.46059277
18protein neddylation (GO:0045116)3.43003103
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35902282
20ATP synthesis coupled proton transport (GO:0015986)3.35902282
21regulation of helicase activity (GO:0051095)3.33005128
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31918539
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25852407
24protein-cofactor linkage (GO:0018065)3.25808156
25platelet dense granule organization (GO:0060155)3.24123048
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23713836
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23713836
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19095150
29respiratory chain complex IV assembly (GO:0008535)3.16697621
30preassembly of GPI anchor in ER membrane (GO:0016254)3.05325811
31replication fork processing (GO:0031297)3.05090830
32cytochrome complex assembly (GO:0017004)2.99603258
33cellular ketone body metabolic process (GO:0046950)2.99471731
34telomere maintenance via telomerase (GO:0007004)2.96944464
35adaptation of signaling pathway (GO:0023058)2.94474721
36fucose catabolic process (GO:0019317)2.91079605
37L-fucose metabolic process (GO:0042354)2.91079605
38L-fucose catabolic process (GO:0042355)2.91079605
39regulation of cilium movement (GO:0003352)2.88989147
40negative regulation of appetite (GO:0032099)2.88877415
41negative regulation of response to food (GO:0032096)2.88877415
42nonmotile primary cilium assembly (GO:0035058)2.88757422
43piRNA metabolic process (GO:0034587)2.88002221
44regulation of telomerase activity (GO:0051972)2.83284610
45DNA deamination (GO:0045006)2.82712793
46axoneme assembly (GO:0035082)2.80647670
47cilium morphogenesis (GO:0060271)2.77804436
48ketone body metabolic process (GO:1902224)2.74621529
49detection of light stimulus involved in visual perception (GO:0050908)2.74590218
50detection of light stimulus involved in sensory perception (GO:0050962)2.74590218
51cullin deneddylation (GO:0010388)2.72515223
52DNA double-strand break processing (GO:0000729)2.70966015
53electron transport chain (GO:0022900)2.67641354
54intraciliary transport (GO:0042073)2.66854948
55protein K6-linked ubiquitination (GO:0085020)2.66723224
56tryptophan catabolic process (GO:0006569)2.66062668
57indole-containing compound catabolic process (GO:0042436)2.66062668
58indolalkylamine catabolic process (GO:0046218)2.66062668
59indolalkylamine metabolic process (GO:0006586)2.65614088
60cilium movement (GO:0003341)2.65593056
61pyrimidine nucleobase catabolic process (GO:0006208)2.64118159
62respiratory electron transport chain (GO:0022904)2.62665646
63reflex (GO:0060004)2.59835504
64glycerophospholipid catabolic process (GO:0046475)2.57943174
65DNA damage response, detection of DNA damage (GO:0042769)2.56509865
66negative regulation of DNA-dependent DNA replication (GO:2000104)2.56232141
67negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55071867
68sulfation (GO:0051923)2.55009150
69recombinational repair (GO:0000725)2.54061627
70regulation of meiosis I (GO:0060631)2.52982826
71negative regulation of heart rate (GO:0010459)2.51108051
72neural tube formation (GO:0001841)2.50880045
73brain morphogenesis (GO:0048854)2.50670534
74double-strand break repair via homologous recombination (GO:0000724)2.50422576
75mannosylation (GO:0097502)2.49686005
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49602545
77protein deneddylation (GO:0000338)2.49232171
78neuronal action potential (GO:0019228)2.48806417
79somite development (GO:0061053)2.47577177
80cell proliferation in forebrain (GO:0021846)2.46708832
81reciprocal meiotic recombination (GO:0007131)2.43732420
82reciprocal DNA recombination (GO:0035825)2.43732420
83kidney morphogenesis (GO:0060993)2.42170288
84nucleotide transmembrane transport (GO:1901679)2.41681611
85nephron tubule morphogenesis (GO:0072078)2.41628225
86nephron epithelium morphogenesis (GO:0072088)2.41628225
87regulation of hexokinase activity (GO:1903299)2.41541781
88regulation of glucokinase activity (GO:0033131)2.41541781
89dopamine transport (GO:0015872)2.41214429
90single strand break repair (GO:0000012)2.40883669
91cilium organization (GO:0044782)2.40611497
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39808959
93cornea development in camera-type eye (GO:0061303)2.38508807
94intracellular protein transmembrane import (GO:0044743)2.38397065
95nucleobase catabolic process (GO:0046113)2.38337857
96transmission of nerve impulse (GO:0019226)2.37788308
97cilium assembly (GO:0042384)2.36764597
98gamma-aminobutyric acid transport (GO:0015812)2.36238461
99maturation of 5.8S rRNA (GO:0000460)2.35724237
100tryptophan metabolic process (GO:0006568)2.35025924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.45122600
2VDR_22108803_ChIP-Seq_LS180_Human3.24742730
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20051906
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02613635
5GBX2_23144817_ChIP-Seq_PC3_Human2.96833667
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81948947
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64506374
8EZH2_22144423_ChIP-Seq_EOC_Human2.55168078
9IGF1R_20145208_ChIP-Seq_DFB_Human2.54550608
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.36511892
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36054741
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31134407
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30136483
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.25595184
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24858781
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23202404
17EWS_26573619_Chip-Seq_HEK293_Human2.20704569
18TAF15_26573619_Chip-Seq_HEK293_Human2.14813305
19FUS_26573619_Chip-Seq_HEK293_Human2.12888662
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09046244
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97208971
22ER_23166858_ChIP-Seq_MCF-7_Human1.80980771
23P300_19829295_ChIP-Seq_ESCs_Human1.80006655
24MYC_18940864_ChIP-ChIP_HL60_Human1.79458278
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78715400
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.72229804
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67555764
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65796640
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61666823
30IRF1_19129219_ChIP-ChIP_H3396_Human1.57854557
31TP53_22573176_ChIP-Seq_HFKS_Human1.57188379
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56325444
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51971846
34CBP_20019798_ChIP-Seq_JUKART_Human1.49485859
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49485859
36BCAT_22108803_ChIP-Seq_LS180_Human1.48994977
37ELK1_19687146_ChIP-ChIP_HELA_Human1.48292269
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.46415356
39VDR_23849224_ChIP-Seq_CD4+_Human1.46303218
40REST_21632747_ChIP-Seq_MESCs_Mouse1.45159204
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42062637
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41097043
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40111502
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36671709
45SMAD4_21799915_ChIP-Seq_A2780_Human1.35747919
46AR_25329375_ChIP-Seq_VCAP_Human1.34896012
47STAT3_23295773_ChIP-Seq_U87_Human1.33242165
48AR_21572438_ChIP-Seq_LNCaP_Human1.32518290
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.31455342
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28447181
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27940669
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27505155
53TCF4_23295773_ChIP-Seq_U87_Human1.27040026
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.26936313
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26936313
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26838445
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25721940
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24919427
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.24696937
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.21801974
61RNF2_27304074_Chip-Seq_NSC_Mouse1.21635927
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21262553
63TCF4_22108803_ChIP-Seq_LS180_Human1.20535419
64NCOR_22424771_ChIP-Seq_293T_Human1.18676651
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18659174
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.18000139
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17884152
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.17357092
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16874641
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16294353
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15084774
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.14628438
73SOX2_19829295_ChIP-Seq_ESCs_Human1.12329279
74NANOG_19829295_ChIP-Seq_ESCs_Human1.12329279
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12265910
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12265910
77RUNX2_22187159_ChIP-Seq_PCA_Human1.12132135
78AR_20517297_ChIP-Seq_VCAP_Human1.11550716
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08648204
80HTT_18923047_ChIP-ChIP_STHdh_Human1.08110527
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07667144
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.06814501
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.06519297
84FOXP3_21729870_ChIP-Seq_TREG_Human1.06232419
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.05762910
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04628557
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03296104
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01061110
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96453129
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96368798
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96120909
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96055367
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.96043123
94HOXB7_26014856_ChIP-Seq_BT474_Human0.95927408
95P53_22387025_ChIP-Seq_ESCs_Mouse0.95478650
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95273510
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94947497
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92804885
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.92318640
100* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92232540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.55370812
2MP0008877_abnormal_DNA_methylation2.88773950
3MP0004147_increased_porphyrin_level2.65820853
4MP0006292_abnormal_olfactory_placode2.42884015
5MP0002102_abnormal_ear_morphology2.42529635
6MP0003787_abnormal_imprinting2.40768542
7MP0003880_abnormal_central_pattern2.37618988
8MP0003646_muscle_fatigue2.33286201
9MP0005551_abnormal_eye_electrophysiolog2.28854877
10MP0005646_abnormal_pituitary_gland2.27890170
11MP0004133_heterotaxia2.26010647
12MP0006072_abnormal_retinal_apoptosis2.20758700
13MP0003195_calcinosis2.14724260
14MP0002876_abnormal_thyroid_physiology2.13686624
15MP0001968_abnormal_touch/_nociception2.08379208
16MP0002653_abnormal_ependyma_morphology2.03927057
17MP0000372_irregular_coat_pigmentation1.92621877
18MP0002736_abnormal_nociception_after1.89048572
19MP0001986_abnormal_taste_sensitivity1.86037750
20MP0002163_abnormal_gland_morphology1.85831506
21MP0006276_abnormal_autonomic_nervous1.83703313
22MP0000631_abnormal_neuroendocrine_gland1.77395057
23MP0003136_yellow_coat_color1.72999722
24MP0001485_abnormal_pinna_reflex1.71598763
25MP0005645_abnormal_hypothalamus_physiol1.70858881
26MP0008875_abnormal_xenobiotic_pharmacok1.70743860
27MP0009745_abnormal_behavioral_response1.68713944
28MP0008995_early_reproductive_senescence1.66501571
29MP0005379_endocrine/exocrine_gland_phen1.66178708
30MP0003122_maternal_imprinting1.60581485
31MP0002638_abnormal_pupillary_reflex1.60519689
32MP0005253_abnormal_eye_physiology1.57551510
33MP0003011_delayed_dark_adaptation1.57487291
34MP0001529_abnormal_vocalization1.56137126
35MP0008872_abnormal_physiological_respon1.52327969
36MP0002735_abnormal_chemical_nociception1.50577539
37MP0000427_abnormal_hair_cycle1.50425653
38MP0002272_abnormal_nervous_system1.49614554
39MP0009046_muscle_twitch1.49528585
40MP0008775_abnormal_heart_ventricle1.49113790
41MP0004142_abnormal_muscle_tone1.46503452
42MP0002822_catalepsy1.46273830
43MP0001984_abnormal_olfaction1.46019765
44MP0003121_genomic_imprinting1.45230632
45MP0008789_abnormal_olfactory_epithelium1.40990105
46MP0002938_white_spotting1.40875994
47MP0003890_abnormal_embryonic-extraembry1.38400949
48MP0005075_abnormal_melanosome_morpholog1.29829351
49MP0001905_abnormal_dopamine_level1.27985278
50MP0001486_abnormal_startle_reflex1.24945481
51MP0004885_abnormal_endolymph1.24874784
52MP0002557_abnormal_social/conspecific_i1.24797904
53MP0005084_abnormal_gallbladder_morpholo1.18357538
54MP0008058_abnormal_DNA_repair1.16216278
55MP0002572_abnormal_emotion/affect_behav1.12853445
56MP0003718_maternal_effect1.11970111
57MP0002064_seizures1.09708393
58MP0003283_abnormal_digestive_organ1.09493328
59MP0000569_abnormal_digit_pigmentation1.08530159
60MP0005410_abnormal_fertilization1.06899673
61MP0005332_abnormal_amino_acid1.04580748
62MP0005499_abnormal_olfactory_system1.03616022
63MP0005394_taste/olfaction_phenotype1.03616022
64MP0000230_abnormal_systemic_arterial1.03123473
65MP0001970_abnormal_pain_threshold1.02436655
66MP0004270_analgesia1.01554651
67MP0005174_abnormal_tail_pigmentation1.00472622
68MP0005389_reproductive_system_phenotype0.99225058
69MP0002733_abnormal_thermal_nociception0.98994881
70MP0000778_abnormal_nervous_system0.96822031
71MP0002734_abnormal_mechanical_nocicepti0.96787393
72MP0002063_abnormal_learning/memory/cond0.96644940
73MP0002095_abnormal_skin_pigmentation0.95099696
74MP0005195_abnormal_posterior_eye0.94793128
75MP0002067_abnormal_sensory_capabilities0.94673842
76MP0000647_abnormal_sebaceous_gland0.94355024
77MP0002160_abnormal_reproductive_system0.93807305
78MP0004043_abnormal_pH_regulation0.93695010
79MP0000383_abnormal_hair_follicle0.92675787
80MP0003635_abnormal_synaptic_transmissio0.92291125
81MP0002909_abnormal_adrenal_gland0.91775130
82MP0002751_abnormal_autonomic_nervous0.90864690
83MP0002184_abnormal_innervation0.88865846
84MP0004924_abnormal_behavior0.88555755
85MP0005386_behavior/neurological_phenoty0.88555755
86MP0002693_abnormal_pancreas_physiology0.86654508
87MP0001963_abnormal_hearing_physiology0.86456336
88MP0002210_abnormal_sex_determination0.83915883
89MP0004742_abnormal_vestibular_system0.82470461
90MP0005636_abnormal_mineral_homeostasis0.81904422
91MP0004145_abnormal_muscle_electrophysio0.81862299
92MP0003137_abnormal_impulse_conducting0.80537768
93MP0000026_abnormal_inner_ear0.80104614
94MP0001929_abnormal_gametogenesis0.79980874
95MP0001944_abnormal_pancreas_morphology0.79773495
96MP0003698_abnormal_male_reproductive0.79751283
97MP0010386_abnormal_urinary_bladder0.77827657
98MP0002752_abnormal_somatic_nervous0.77050129
99MP0002229_neurodegeneration0.76894425
100MP0001919_abnormal_reproductive_system0.75824473

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.87970671
2Abnormality of midbrain morphology (HP:0002418)3.70779735
3Molar tooth sign on MRI (HP:0002419)3.70779735
4Pancreatic fibrosis (HP:0100732)3.65799931
5True hermaphroditism (HP:0010459)3.65589213
6Congenital stationary night blindness (HP:0007642)3.41759939
7Nephronophthisis (HP:0000090)3.41168789
8Hyperventilation (HP:0002883)2.99775270
9Medial flaring of the eyebrow (HP:0010747)2.87585167
10Mitochondrial inheritance (HP:0001427)2.83492693
11Abnormality of the renal medulla (HP:0100957)2.76847304
12Increased CSF lactate (HP:0002490)2.72820479
13Hepatocellular necrosis (HP:0001404)2.69491919
14Hepatic necrosis (HP:0002605)2.68669972
15Acute necrotizing encephalopathy (HP:0006965)2.65601420
16Abnormality of the renal cortex (HP:0011035)2.62059805
17Renal cortical cysts (HP:0000803)2.60169480
18Pendular nystagmus (HP:0012043)2.59859348
19Methylmalonic acidemia (HP:0002912)2.57912187
20Attenuation of retinal blood vessels (HP:0007843)2.53489629
21Chronic hepatic failure (HP:0100626)2.53480744
22Gait imbalance (HP:0002141)2.46833578
23Decreased circulating renin level (HP:0003351)2.46752677
24Acute encephalopathy (HP:0006846)2.46622293
25Abolished electroretinogram (ERG) (HP:0000550)2.44611401
26Esophageal atresia (HP:0002032)2.40944732
27Congenital primary aphakia (HP:0007707)2.38545385
28Decreased central vision (HP:0007663)2.37878559
29Gastrointestinal atresia (HP:0002589)2.36317715
30Abnormal rod and cone electroretinograms (HP:0008323)2.34514304
31Progressive macrocephaly (HP:0004481)2.33729719
32Abnormal mitochondria in muscle tissue (HP:0008316)2.33269188
33Renal Fanconi syndrome (HP:0001994)2.32806162
34Nephrogenic diabetes insipidus (HP:0009806)2.24412631
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23984043
36Abnormality of alanine metabolism (HP:0010916)2.23984043
37Hyperalaninemia (HP:0003348)2.23984043
38Type II lissencephaly (HP:0007260)2.23443177
39Increased hepatocellular lipid droplets (HP:0006565)2.23236907
40Cystic liver disease (HP:0006706)2.18890322
41Hypothermia (HP:0002045)2.16402993
42Optic nerve hypoplasia (HP:0000609)2.12902726
43Polydipsia (HP:0001959)2.11242551
44Abnormal drinking behavior (HP:0030082)2.11242551
453-Methylglutaconic aciduria (HP:0003535)2.11182285
46Lipid accumulation in hepatocytes (HP:0006561)2.10806786
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10263806
48Methylmalonic aciduria (HP:0012120)2.10078605
49Large for gestational age (HP:0001520)2.09223377
50Male pseudohermaphroditism (HP:0000037)2.08774133
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.08712013
52Absent/shortened dynein arms (HP:0200106)2.07399485
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.07399485
54Colon cancer (HP:0003003)2.01777554
55Anencephaly (HP:0002323)2.00734882
56Optic disc pallor (HP:0000543)1.99484678
57Genital tract atresia (HP:0001827)1.98966009
58Abnormality of urine glucose concentration (HP:0011016)1.97867274
59Glycosuria (HP:0003076)1.97867274
60Sclerocornea (HP:0000647)1.96839636
61Abnormality of the labia minora (HP:0012880)1.96254942
62Septo-optic dysplasia (HP:0100842)1.94354050
63Generalized aminoaciduria (HP:0002909)1.94210178
64Abnormal respiratory epithelium morphology (HP:0012253)1.93714126
65Abnormal respiratory motile cilium morphology (HP:0005938)1.93714126
66Abnormal biliary tract physiology (HP:0012439)1.92760267
67Bile duct proliferation (HP:0001408)1.92760267
68Congenital, generalized hypertrichosis (HP:0004540)1.91825444
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.91360883
70Intestinal atresia (HP:0011100)1.91088018
71Vaginal atresia (HP:0000148)1.90970404
72Hyperglycinemia (HP:0002154)1.90941169
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.90648835
74Increased serum lactate (HP:0002151)1.88592128
75Asplenia (HP:0001746)1.87238119
76Inability to walk (HP:0002540)1.83425757
77Tubular atrophy (HP:0000092)1.82952627
78Hypoplasia of the fovea (HP:0007750)1.81912010
79Aplasia/Hypoplasia of the fovea (HP:0008060)1.81912010
80Poor coordination (HP:0002370)1.80258990
81Congenital hepatic fibrosis (HP:0002612)1.77468039
82Hemiparesis (HP:0001269)1.77266588
83Furrowed tongue (HP:0000221)1.77211503
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76924770
85Lissencephaly (HP:0001339)1.75380230
86Abnormality of the ileum (HP:0001549)1.73383187
87Cerebral edema (HP:0002181)1.73123858
88Abnormality of vitamin B metabolism (HP:0004340)1.73077117
89Supernumerary spleens (HP:0009799)1.72424076
90Meckel diverticulum (HP:0002245)1.71826319
91Pachygyria (HP:0001302)1.71184686
92Bony spicule pigmentary retinopathy (HP:0007737)1.71165023
93Postaxial foot polydactyly (HP:0001830)1.70759798
94Tachypnea (HP:0002789)1.70636048
95Abnormality of the pons (HP:0007361)1.70626438
96Absent thumb (HP:0009777)1.70504619
97Abnormality of renal resorption (HP:0011038)1.70350331
98Agitation (HP:0000713)1.70213502
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.69045151
100Ketosis (HP:0001946)1.68859402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.33103641
2MAP4K24.10633279
3TLK13.82326984
4TAOK23.65941444
5MAP2K63.11390136
6ZAK2.57148001
7ADRBK22.43883365
8WNK32.39707598
9WNK42.31690044
10CASK2.24986345
11NUAK12.10100327
12TAOK31.95599947
13GRK11.87693913
14BMPR1B1.75447150
15NME11.75386689
16MAPK131.69785960
17PINK11.64154866
18BCKDK1.64112326
19MAP3K41.57957840
20TNIK1.57843746
21STK391.56596014
22VRK21.49006858
23ACVR1B1.45684661
24INSRR1.43007301
25DYRK21.41727182
26OXSR11.31071348
27TXK1.17676614
28VRK11.15506968
29MKNK21.14988755
30MAP3K51.13530906
31SIK21.12013601
32PNCK1.08360770
33BRSK21.06074273
34TRIM281.04528206
35CSNK1G11.04342226
36CSNK1G31.03598702
37MST41.00132657
38PAK30.99864586
39NLK0.95740298
40MARK10.95679204
41PRKCG0.93608665
42PLK20.93535131
43MUSK0.93200470
44CSNK1G20.93007706
45EIF2AK30.90038083
46PHKG20.89719424
47PHKG10.89719424
48FGFR20.85246113
49PIK3CA0.85068303
50PRKCE0.83745498
51EPHA30.81642787
52PLK30.81254775
53CSNK1A1L0.78304898
54MAP2K70.77460602
55PLK40.75142330
56WEE10.75114054
57NTRK30.71162176
58ADRBK10.65413385
59DAPK20.62884794
60MKNK10.62728321
61BCR0.61619775
62RPS6KA50.55435099
63MAPK150.55335521
64CAMKK20.54578285
65RIPK40.54558435
66PRKCQ0.52569896
67STK160.52387166
68MAPKAPK50.51499665
69TEC0.47667678
70TGFBR10.46974074
71TAF10.46940780
72ATR0.44552607
73KIT0.43824020
74PKN10.42497736
75PRKACA0.42170275
76CSNK1A10.41751780
77BUB10.39820689
78STK110.39786766
79CDK30.38260456
80CHEK20.38188775
81PASK0.36881092
82EPHA40.36665250
83CAMK2A0.34538122
84SYK0.33987397
85PRKCI0.33922308
86PRKCZ0.32620595
87FER0.32605482
88TIE10.31866395
89TNK20.31659012
90PLK10.31054590
91CSNK1D0.30659696
92ERBB30.30450433
93NTRK20.29933963
94MAPKAPK30.29361355
95PRKCA0.28363933
96ATM0.28088421
97EIF2AK20.26835353
98FLT30.26781610
99IRAK10.26735336
100STK38L0.26528964

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.29979511
2Parkinsons disease_Homo sapiens_hsa050122.69922366
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52195579
4Phototransduction_Homo sapiens_hsa047442.45071134
5Homologous recombination_Homo sapiens_hsa034402.44604597
6Protein export_Homo sapiens_hsa030602.37187467
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.26878398
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24651025
9Fanconi anemia pathway_Homo sapiens_hsa034602.22815506
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22033906
11Butanoate metabolism_Homo sapiens_hsa006502.21507498
12Linoleic acid metabolism_Homo sapiens_hsa005911.86295406
13RNA polymerase_Homo sapiens_hsa030201.82292500
14Nicotine addiction_Homo sapiens_hsa050331.77891479
15Alzheimers disease_Homo sapiens_hsa050101.75644946
16Nitrogen metabolism_Homo sapiens_hsa009101.75433934
17Selenocompound metabolism_Homo sapiens_hsa004501.73754158
18Huntingtons disease_Homo sapiens_hsa050161.73590599
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73197279
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70808724
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70735931
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68531103
23Basal transcription factors_Homo sapiens_hsa030221.66209376
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63046497
25Regulation of autophagy_Homo sapiens_hsa041401.46181155
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44654771
27Cardiac muscle contraction_Homo sapiens_hsa042601.42997638
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39990470
29Propanoate metabolism_Homo sapiens_hsa006401.39935677
30Non-homologous end-joining_Homo sapiens_hsa034501.39558670
31Proteasome_Homo sapiens_hsa030501.31181112
32RNA degradation_Homo sapiens_hsa030181.29208453
33Collecting duct acid secretion_Homo sapiens_hsa049661.26166884
34Ether lipid metabolism_Homo sapiens_hsa005651.24260867
35Mismatch repair_Homo sapiens_hsa034301.21012191
36One carbon pool by folate_Homo sapiens_hsa006701.20642903
37Peroxisome_Homo sapiens_hsa041461.18078701
38Taste transduction_Homo sapiens_hsa047421.17764492
39Ribosome_Homo sapiens_hsa030101.14413382
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10582811
41Tryptophan metabolism_Homo sapiens_hsa003801.10524266
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08834339
43Chemical carcinogenesis_Homo sapiens_hsa052041.07572204
44GABAergic synapse_Homo sapiens_hsa047271.03918887
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01106994
46Olfactory transduction_Homo sapiens_hsa047400.99813816
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.98937427
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98573872
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96643320
50Morphine addiction_Homo sapiens_hsa050320.93411174
51Purine metabolism_Homo sapiens_hsa002300.93060763
52Retinol metabolism_Homo sapiens_hsa008300.88049163
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88005298
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87865620
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87830786
56Nucleotide excision repair_Homo sapiens_hsa034200.86208152
57Fatty acid elongation_Homo sapiens_hsa000620.85120870
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84902427
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84316562
60Steroid biosynthesis_Homo sapiens_hsa001000.82790033
61Pyrimidine metabolism_Homo sapiens_hsa002400.81649348
62Serotonergic synapse_Homo sapiens_hsa047260.81200420
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81046211
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80672468
65Circadian entrainment_Homo sapiens_hsa047130.78994328
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78828135
67Caffeine metabolism_Homo sapiens_hsa002320.78496438
68Arachidonic acid metabolism_Homo sapiens_hsa005900.78193528
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.78045757
70Insulin secretion_Homo sapiens_hsa049110.77343001
71Metabolic pathways_Homo sapiens_hsa011000.77113965
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75544714
73Glutamatergic synapse_Homo sapiens_hsa047240.73737995
74ABC transporters_Homo sapiens_hsa020100.69432848
75Cocaine addiction_Homo sapiens_hsa050300.67203100
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65261628
77Base excision repair_Homo sapiens_hsa034100.62690248
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58896365
79beta-Alanine metabolism_Homo sapiens_hsa004100.58181939
80Glutathione metabolism_Homo sapiens_hsa004800.57104346
81Sulfur relay system_Homo sapiens_hsa041220.56665871
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52987155
83Glycerolipid metabolism_Homo sapiens_hsa005610.52835085
84Circadian rhythm_Homo sapiens_hsa047100.52152470
85Primary immunodeficiency_Homo sapiens_hsa053400.49854463
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.49773648
87Fat digestion and absorption_Homo sapiens_hsa049750.46121802
88Dopaminergic synapse_Homo sapiens_hsa047280.45769363
89DNA replication_Homo sapiens_hsa030300.44963754
90RNA transport_Homo sapiens_hsa030130.43370333
91Sulfur metabolism_Homo sapiens_hsa009200.43093668
92Vitamin digestion and absorption_Homo sapiens_hsa049770.42481861
93Histidine metabolism_Homo sapiens_hsa003400.41589921
94Amphetamine addiction_Homo sapiens_hsa050310.40959916
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.40765787
96Calcium signaling pathway_Homo sapiens_hsa040200.40321728
97Ovarian steroidogenesis_Homo sapiens_hsa049130.39331883
98Salivary secretion_Homo sapiens_hsa049700.39016530
99Mineral absorption_Homo sapiens_hsa049780.33686063
100Dorso-ventral axis formation_Homo sapiens_hsa043200.32589973

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