NCAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.17007473
2vocalization behavior (GO:0071625)5.12213328
3pyrimidine nucleobase catabolic process (GO:0006208)5.07674527
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84555314
5neuron recognition (GO:0008038)4.83612480
6protein localization to synapse (GO:0035418)4.60240484
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57475303
8postsynaptic membrane organization (GO:0001941)4.47807106
9presynaptic membrane assembly (GO:0097105)4.46134484
10axonal fasciculation (GO:0007413)4.43368329
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32406805
12dendritic spine morphogenesis (GO:0060997)4.32171227
13synaptic vesicle exocytosis (GO:0016079)4.29699030
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25733078
15regulation of glutamate receptor signaling pathway (GO:1900449)4.23189431
16layer formation in cerebral cortex (GO:0021819)4.21594414
17presynaptic membrane organization (GO:0097090)4.17265777
18nucleobase catabolic process (GO:0046113)4.06730282
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.02718890
20cell migration in hindbrain (GO:0021535)3.98889936
21dendrite morphogenesis (GO:0048813)3.97093975
22locomotory exploration behavior (GO:0035641)3.94773383
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90505390
24exploration behavior (GO:0035640)3.88018773
25glutamate receptor signaling pathway (GO:0007215)3.85533923
26negative regulation of microtubule polymerization (GO:0031115)3.81173294
27positive regulation of synapse assembly (GO:0051965)3.79270509
28cellular potassium ion homeostasis (GO:0030007)3.77220732
29axon ensheathment in central nervous system (GO:0032291)3.76571887
30central nervous system myelination (GO:0022010)3.76571887
31neuronal ion channel clustering (GO:0045161)3.75431434
32synaptic vesicle maturation (GO:0016188)3.73557226
33central nervous system projection neuron axonogenesis (GO:0021952)3.73514284
34regulation of synaptic vesicle exocytosis (GO:2000300)3.68399577
35glutamate secretion (GO:0014047)3.63484252
36regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.63259780
37regulation of synapse structural plasticity (GO:0051823)3.61106799
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.58040076
39synaptic transmission, glutamatergic (GO:0035249)3.57928607
40neurotransmitter-gated ion channel clustering (GO:0072578)3.57321575
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47103929
42neuron-neuron synaptic transmission (GO:0007270)3.42587762
43neurotransmitter secretion (GO:0007269)3.40383610
44membrane depolarization during action potential (GO:0086010)3.40093583
45sodium ion export (GO:0071436)3.40006231
46synapse assembly (GO:0007416)3.37385898
47transmission of nerve impulse (GO:0019226)3.35024374
48establishment of mitochondrion localization (GO:0051654)3.32423221
49neuromuscular synaptic transmission (GO:0007274)3.27456501
50auditory behavior (GO:0031223)3.24876080
51proline transport (GO:0015824)3.24210101
52gamma-aminobutyric acid transport (GO:0015812)3.21535235
53regulation of respiratory system process (GO:0044065)3.19572610
54behavioral response to nicotine (GO:0035095)3.17534755
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17300045
56regulation of neuronal synaptic plasticity (GO:0048168)3.17193115
57axon extension (GO:0048675)3.17130686
58startle response (GO:0001964)3.16998208
59cell communication by electrical coupling (GO:0010644)3.15773505
60regulation of synaptic vesicle transport (GO:1902803)3.15527481
61dendrite development (GO:0016358)3.14444401
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13110308
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13001197
64regulation of synapse assembly (GO:0051963)3.12111162
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10129633
66regulation of postsynaptic membrane potential (GO:0060078)3.08654264
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08395295
68central nervous system neuron axonogenesis (GO:0021955)3.06691380
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04947796
70adult walking behavior (GO:0007628)3.04876567
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03407053
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.03054754
73innervation (GO:0060384)3.02169249
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.00681932
75cerebral cortex radially oriented cell migration (GO:0021799)3.00302969
76positive regulation of synapse maturation (GO:0090129)3.00013940
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99732760
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.98340948
79cerebellar granule cell differentiation (GO:0021707)2.98046319
80cerebellar Purkinje cell differentiation (GO:0021702)2.97981629
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97626760
82positive regulation of membrane potential (GO:0045838)2.97536119
83mitochondrion transport along microtubule (GO:0047497)2.97298931
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.97298931
85gamma-aminobutyric acid signaling pathway (GO:0007214)2.96937958
86synapse organization (GO:0050808)2.96834923
87neurotransmitter transport (GO:0006836)2.95901566
88membrane hyperpolarization (GO:0060081)2.94781447
89response to pheromone (GO:0019236)2.93928034
90regulation of respiratory gaseous exchange (GO:0043576)2.93394383
91response to auditory stimulus (GO:0010996)2.93084881
92hippocampus development (GO:0021766)2.93034725
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.90232486
94regulation of dendritic spine morphogenesis (GO:0061001)2.89802683
95long-term memory (GO:0007616)2.88973991
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.86797122
97mechanosensory behavior (GO:0007638)2.86288256
98regulation of synapse organization (GO:0050807)2.85745792
99synaptic vesicle endocytosis (GO:0048488)2.85423769
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85364659
101regulation of neurotransmitter levels (GO:0001505)2.85317068
102membrane assembly (GO:0071709)2.84905907
103regulation of vesicle fusion (GO:0031338)2.83456065
104regulation of neurotransmitter secretion (GO:0046928)2.83275272
105negative regulation of axon extension (GO:0030517)2.82903332
106response to histamine (GO:0034776)2.81673900
107cellular sodium ion homeostasis (GO:0006883)2.81495346
108neuronal action potential propagation (GO:0019227)2.81285904
109potassium ion homeostasis (GO:0055075)2.80766580
110negative regulation of axonogenesis (GO:0050771)2.77917998
111positive regulation of dendritic spine development (GO:0060999)2.77432567
112potassium ion import (GO:0010107)2.77377752
113cell communication involved in cardiac conduction (GO:0086065)2.76143716
114dendritic spine organization (GO:0097061)2.75937672
115learning (GO:0007612)2.75077299
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74283520
117cell differentiation in hindbrain (GO:0021533)2.74260842
118prepulse inhibition (GO:0060134)2.72135400
119membrane depolarization (GO:0051899)2.70971600
120mating behavior (GO:0007617)2.68989075
121negative regulation of neurotransmitter transport (GO:0051589)2.68367925
122homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.67911244
123neuron projection extension (GO:1990138)2.67871442
124dopamine receptor signaling pathway (GO:0007212)2.67558864
125regulation of synapse maturation (GO:0090128)2.67090504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29254963
2GBX2_23144817_ChIP-Seq_PC3_Human3.84539580
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02601062
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97636999
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85832864
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.83511400
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58076806
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57777582
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55511736
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55511736
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46460206
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.43756540
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42906253
14REST_21632747_ChIP-Seq_MESCs_Mouse2.34324394
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29405809
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.23527056
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23073552
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22517092
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19292061
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.16227360
21TAF15_26573619_Chip-Seq_HEK293_Human2.14725227
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13577343
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11515310
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.05888693
25AR_21572438_ChIP-Seq_LNCaP_Human2.02537150
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99560203
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97005908
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91463031
29* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86792616
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.85608596
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83429077
32DROSHA_22980978_ChIP-Seq_HELA_Human1.82687726
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79905949
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79179853
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69391537
36* P300_19829295_ChIP-Seq_ESCs_Human1.66974204
37RNF2_27304074_Chip-Seq_NSC_Mouse1.65316220
38ZNF274_21170338_ChIP-Seq_K562_Hela1.64705409
39SMAD4_21799915_ChIP-Seq_A2780_Human1.60807392
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.58764079
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56002890
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54768042
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54244007
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51517368
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50985713
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50486049
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49383279
48IGF1R_20145208_ChIP-Seq_DFB_Human1.47882354
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46593020
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46034953
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42899369
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.37861993
53FUS_26573619_Chip-Seq_HEK293_Human1.36948298
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36022125
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33921645
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33600710
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33519405
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29049869
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.25455963
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23956569
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23875596
62AR_25329375_ChIP-Seq_VCAP_Human1.23597769
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21975040
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20625423
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20625423
66STAT3_23295773_ChIP-Seq_U87_Human1.19227447
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19069130
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.19064062
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18275386
70ER_23166858_ChIP-Seq_MCF-7_Human1.16552272
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.16347199
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16153130
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14550037
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.13591428
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13542797
76VDR_22108803_ChIP-Seq_LS180_Human1.12833084
77AHR_22903824_ChIP-Seq_MCF-7_Human1.10351931
78* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10335885
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08956795
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08787585
81* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08548644
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07172931
83TCF4_23295773_ChIP-Seq_U87_Human1.06540746
84* AR_19668381_ChIP-Seq_PC3_Human1.06277962
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05362995
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.02920849
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01689280
88JUN_21703547_ChIP-Seq_K562_Human1.01262074
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.01039722
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00613904
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99527882
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99297227
93* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99276906
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98841606
95TP53_18474530_ChIP-ChIP_U2OS_Human0.98525984
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98055464
97* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97209757
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96789900
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.96729577
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.96240877
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92400417
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92021489
103* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91229335
104SOX9_26525672_Chip-Seq_HEART_Mouse0.90935425
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90463676
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90171219
107* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89185009
108KDM2B_26808549_Chip-Seq_REH_Human0.88725019
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.88554083
110EWS_26573619_Chip-Seq_HEK293_Human0.87904807
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87722563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.29218875
2MP0004859_abnormal_synaptic_plasticity4.15592012
3MP0004270_analgesia3.50766455
4MP0005423_abnormal_somatic_nervous3.33714520
5* MP0003635_abnormal_synaptic_transmissio3.33279868
6MP0000778_abnormal_nervous_system2.83648781
7* MP0002063_abnormal_learning/memory/cond2.78548191
8MP0009745_abnormal_behavioral_response2.70250020
9MP0006276_abnormal_autonomic_nervous2.66047591
10MP0002734_abnormal_mechanical_nocicepti2.65609601
11MP0002572_abnormal_emotion/affect_behav2.53795871
12MP0002064_seizures2.49520896
13MP0001968_abnormal_touch/_nociception2.42263990
14MP0009046_muscle_twitch2.37437908
15MP0001486_abnormal_startle_reflex2.36728116
16MP0002184_abnormal_innervation2.34177077
17MP0002735_abnormal_chemical_nociception2.23783719
18MP0002272_abnormal_nervous_system2.17388190
19MP0001529_abnormal_vocalization2.12178032
20MP0005645_abnormal_hypothalamus_physiol2.09636859
21MP0001440_abnormal_grooming_behavior2.08081934
22MP0001984_abnormal_olfaction2.05137730
23MP0002733_abnormal_thermal_nociception1.97943821
24MP0002557_abnormal_social/conspecific_i1.95286170
25MP0002736_abnormal_nociception_after1.88746868
26MP0002067_abnormal_sensory_capabilities1.86956815
27MP0001970_abnormal_pain_threshold1.85367877
28MP0003122_maternal_imprinting1.83063115
29MP0004924_abnormal_behavior1.72556009
30MP0005386_behavior/neurological_phenoty1.72556009
31MP0001188_hyperpigmentation1.71111984
32MP0000955_abnormal_spinal_cord1.67076004
33MP0004858_abnormal_nervous_system1.63537429
34* MP0002882_abnormal_neuron_morphology1.61733064
35MP0001905_abnormal_dopamine_level1.59705765
36MP0002822_catalepsy1.58018125
37MP0004811_abnormal_neuron_physiology1.56961642
38MP0001501_abnormal_sleep_pattern1.54222570
39MP0004742_abnormal_vestibular_system1.48243707
40MP0005394_taste/olfaction_phenotype1.46099452
41MP0005499_abnormal_olfactory_system1.46099452
42MP0005646_abnormal_pituitary_gland1.43120012
43MP0005551_abnormal_eye_electrophysiolog1.41363543
44MP0000631_abnormal_neuroendocrine_gland1.39718589
45MP0008789_abnormal_olfactory_epithelium1.38897676
46MP0004142_abnormal_muscle_tone1.38654625
47MP0004885_abnormal_endolymph1.37545558
48MP0003787_abnormal_imprinting1.36351665
49MP0008569_lethality_at_weaning1.36092171
50MP0002638_abnormal_pupillary_reflex1.35421682
51MP0002066_abnormal_motor_capabilities/c1.34881346
52MP0003329_amyloid_beta_deposits1.34203205
53* MP0002152_abnormal_brain_morphology1.33556970
54MP0010386_abnormal_urinary_bladder1.30361344
55MP0002102_abnormal_ear_morphology1.27504955
56MP0009780_abnormal_chondrocyte_physiolo1.25202134
57MP0002752_abnormal_somatic_nervous1.24801919
58MP0006072_abnormal_retinal_apoptosis1.20647492
59MP0000751_myopathy1.11687893
60MP0005187_abnormal_penis_morphology1.09230039
61MP0005409_darkened_coat_color1.05787909
62MP0000566_synostosis1.04206604
63* MP0003861_abnormal_nervous_system1.03783186
64MP0002751_abnormal_autonomic_nervous1.01561614
65MP0003690_abnormal_glial_cell1.00371343
66* MP0001502_abnormal_circadian_rhythm1.00253089
67MP0001963_abnormal_hearing_physiology0.99375366
68MP0002229_neurodegeneration0.99185380
69MP0002909_abnormal_adrenal_gland0.98886923
70MP0005171_absent_coat_pigmentation0.98276552
71* MP0003634_abnormal_glial_cell0.98067095
72MP0006292_abnormal_olfactory_placode0.94488503
73MP0000026_abnormal_inner_ear0.94485921
74MP0003121_genomic_imprinting0.94414841
75MP0000569_abnormal_digit_pigmentation0.94380933
76MP0003123_paternal_imprinting0.91909564
77MP0004133_heterotaxia0.91614301
78MP0004215_abnormal_myocardial_fiber0.90441139
79MP0003283_abnormal_digestive_organ0.90193531
80MP0003879_abnormal_hair_cell0.90156335
81MP0002069_abnormal_eating/drinking_beha0.87614500
82MP0001299_abnormal_eye_distance/0.87450449
83MP0005253_abnormal_eye_physiology0.87428359
84MP0008877_abnormal_DNA_methylation0.85426299
85MP0003137_abnormal_impulse_conducting0.82973463
86MP0003631_nervous_system_phenotype0.82710048
87MP0003938_abnormal_ear_development0.82684868
88MP0001485_abnormal_pinna_reflex0.82349931
89MP0000920_abnormal_myelination0.79667211
90MP0004145_abnormal_muscle_electrophysio0.79593945
91MP0003385_abnormal_body_wall0.78650060
92MP0004085_abnormal_heartbeat0.78518658
93MP0003632_abnormal_nervous_system0.78106360
94MP0003633_abnormal_nervous_system0.77827572
95* MP0005195_abnormal_posterior_eye0.75434588
96MP0002653_abnormal_ependyma_morphology0.75183826
97MP0001177_atelectasis0.75104767
98MP0009379_abnormal_foot_pigmentation0.74233783
99MP0000537_abnormal_urethra_morphology0.73205578
100MP0001943_abnormal_respiration0.71759945
101MP0010770_preweaning_lethality0.69799398
102MP0002082_postnatal_lethality0.69799398
103MP0001986_abnormal_taste_sensitivity0.69623599
104MP0002837_dystrophic_cardiac_calcinosis0.68818007
105MP0010769_abnormal_survival0.68049615
106MP0003119_abnormal_digestive_system0.67605762
107MP0000538_abnormal_urinary_bladder0.66343780
108MP0000049_abnormal_middle_ear0.66062186
109MP0003136_yellow_coat_color0.65684912
110MP0005623_abnormal_meninges_morphology0.64614252
111MP0000534_abnormal_ureter_morphology0.64439737
112MP0010768_mortality/aging0.64326644
113MP0002876_abnormal_thyroid_physiology0.64207682
114MP0002081_perinatal_lethality0.63843074
115MP0002938_white_spotting0.63368763

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.68524483
2Myokymia (HP:0002411)4.39230436
3Focal seizures (HP:0007359)4.19695834
4Limb dystonia (HP:0002451)4.03536077
5Epileptic encephalopathy (HP:0200134)3.81679726
6Atonic seizures (HP:0010819)3.66712485
7Febrile seizures (HP:0002373)3.55726662
8Progressive cerebellar ataxia (HP:0002073)3.49224437
9Visual hallucinations (HP:0002367)3.37568310
10Broad-based gait (HP:0002136)3.24585239
11Abnormality of the corticospinal tract (HP:0002492)3.17518969
12Polyphagia (HP:0002591)3.14053681
13Ankle clonus (HP:0011448)3.12535470
14Supranuclear gaze palsy (HP:0000605)3.10754051
15Hyperventilation (HP:0002883)3.09312448
16Drooling (HP:0002307)3.01595512
17Excessive salivation (HP:0003781)3.01595512
18Gait imbalance (HP:0002141)3.01465993
19Absence seizures (HP:0002121)2.96952481
20Akinesia (HP:0002304)2.94602490
21Mutism (HP:0002300)2.89698925
22Dialeptic seizures (HP:0011146)2.78722584
23Amblyopia (HP:0000646)2.76760923
24Neurofibrillary tangles (HP:0002185)2.74195789
25Generalized tonic-clonic seizures (HP:0002069)2.73389708
26Fetal akinesia sequence (HP:0001989)2.65277848
27Amyotrophic lateral sclerosis (HP:0007354)2.64342188
28Cerebral inclusion bodies (HP:0100314)2.54238099
29Aplasia/Hypoplasia of the brainstem (HP:0007362)2.54106645
30Hypoplasia of the brainstem (HP:0002365)2.54106645
31Agitation (HP:0000713)2.50903367
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48918905
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.48918905
34Abnormal eating behavior (HP:0100738)2.46749701
35Insidious onset (HP:0003587)2.44755485
36Termporal pattern (HP:0011008)2.44755485
37Spastic gait (HP:0002064)2.39546445
38Progressive inability to walk (HP:0002505)2.38455658
39Action tremor (HP:0002345)2.38062885
40Absent speech (HP:0001344)2.36835329
41Hemiplegia (HP:0002301)2.35534614
42Lissencephaly (HP:0001339)2.32193414
43Hemiparesis (HP:0001269)2.30817281
44Truncal ataxia (HP:0002078)2.28917788
45Urinary bladder sphincter dysfunction (HP:0002839)2.27860733
46Epileptiform EEG discharges (HP:0011182)2.25698422
47Medial flaring of the eyebrow (HP:0010747)2.23956619
48EEG with generalized epileptiform discharges (HP:0011198)2.23148715
49Abnormality of the lower motor neuron (HP:0002366)2.20778555
50Specific learning disability (HP:0001328)2.19829169
51Pheochromocytoma (HP:0002666)2.18554011
52Congenital primary aphakia (HP:0007707)2.17115001
53Postural instability (HP:0002172)2.14420611
54Abnormal hair whorl (HP:0010721)2.14306534
55Hypothermia (HP:0002045)2.13911178
56Hypsarrhythmia (HP:0002521)2.13390461
57Protruding tongue (HP:0010808)2.12770133
58Prolonged QT interval (HP:0001657)2.12714146
59Impaired vibration sensation in the lower limbs (HP:0002166)2.12704628
60Retinal dysplasia (HP:0007973)2.11560362
61Urinary urgency (HP:0000012)2.11477787
62Diplopia (HP:0000651)2.11348342
63Abnormality of binocular vision (HP:0011514)2.11348342
64Genital tract atresia (HP:0001827)2.11088316
65Lower limb muscle weakness (HP:0007340)2.10176979
66Abnormality of salivation (HP:0100755)2.09854517
67Exotropia (HP:0000577)2.09404927
68Failure to thrive in infancy (HP:0001531)2.09374360
69Anxiety (HP:0000739)2.06977017
70Vaginal atresia (HP:0000148)2.06141328
71Papilledema (HP:0001085)2.05371315
72Megalencephaly (HP:0001355)2.04594498
73Blue irides (HP:0000635)2.03594887
74Nephrogenic diabetes insipidus (HP:0009806)2.01992732
75Poor eye contact (HP:0000817)2.01708001
76Spastic tetraplegia (HP:0002510)2.00331730
77Genetic anticipation (HP:0003743)1.98630216
78Esotropia (HP:0000565)1.98416886
79Syncope (HP:0001279)1.97202519
80Sudden death (HP:0001699)1.95779210
81Hypoplasia of the corpus callosum (HP:0002079)1.95697913
82Split foot (HP:0001839)1.95505482
83Status epilepticus (HP:0002133)1.95248487
84Morphological abnormality of the pyramidal tract (HP:0002062)1.93552310
85Dysdiadochokinesis (HP:0002075)1.93089982
86Inability to walk (HP:0002540)1.91714806
87Depression (HP:0000716)1.90024840
88Dysmetria (HP:0001310)1.89112221
89Intention tremor (HP:0002080)1.88809678
90Torticollis (HP:0000473)1.88465434
91Shoulder girdle muscle weakness (HP:0003547)1.88152206
92Hyperthyroidism (HP:0000836)1.87045125
93Abnormal ciliary motility (HP:0012262)1.86774208
94Gaze-evoked nystagmus (HP:0000640)1.86554372
95Sleep apnea (HP:0010535)1.85426614
96Narrow nasal bridge (HP:0000446)1.85409902
97Hypoventilation (HP:0002791)1.84774406
98Pachygyria (HP:0001302)1.82794934
99Neuroendocrine neoplasm (HP:0100634)1.82780697
100Peripheral hypomyelination (HP:0007182)1.81297288
101Primary atrial arrhythmia (HP:0001692)1.80643680
102Poor suck (HP:0002033)1.80436075
103Abnormality of the labia minora (HP:0012880)1.80003900
104Inappropriate behavior (HP:0000719)1.76514488
105Aplasia/Hypoplasia of the lens (HP:0008063)1.73506221
106Atrial fibrillation (HP:0005110)1.72149057
107Abnormal EKG (HP:0003115)1.72036488
108Abnormal social behavior (HP:0012433)1.71687530
109Impaired social interactions (HP:0000735)1.71687530
110Intellectual disability, severe (HP:0010864)1.70478338
111Shawl scrotum (HP:0000049)1.70385622
112Autism (HP:0000717)1.70172108
113Obstructive sleep apnea (HP:0002870)1.69410341
114Cutaneous finger syndactyly (HP:0010554)1.69296200
115Sporadic (HP:0003745)1.69102110
116Stereotypic behavior (HP:0000733)1.69023245
117Gastroesophageal reflux (HP:0002020)1.68987272
118Supraventricular tachycardia (HP:0004755)1.68927302
119Aqueductal stenosis (HP:0002410)1.68373637
120Incomplete penetrance (HP:0003829)1.68075174
121Focal dystonia (HP:0004373)1.67888940
122Open mouth (HP:0000194)1.67047137
123Ulnar claw (HP:0001178)1.67020877
124Optic nerve hypoplasia (HP:0000609)1.65666369
125Impaired smooth pursuit (HP:0007772)1.65069922
126Craniofacial dystonia (HP:0012179)1.64764054
127Hepatoblastoma (HP:0002884)1.64581258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.09602211
2CASK3.82325177
3NTRK33.00989872
4MAP3K42.92706294
5MAP2K72.90325849
6MAPK132.77716672
7PNCK2.24852251
8DYRK22.22865468
9MINK12.22360770
10EPHA42.16436477
11TNIK2.09486047
12MAP3K92.08731272
13PHKG12.05493150
14PHKG22.05493150
15UHMK11.79682424
16ERBB31.65932801
17* NTRK21.59286538
18SIK21.48664217
19MAP2K41.45989746
20PRPF4B1.45585981
21WNK31.45043186
22PAK61.44818829
23DAPK21.42233632
24PLK21.41375337
25LIMK11.40898054
26PINK11.38354530
27CDK51.35404460
28CSNK1G21.33297673
29MAP3K121.31227158
30KSR11.27321359
31PKN11.23933933
32NTRK11.19455765
33SGK4941.14661408
34SGK2231.14661408
35DYRK1A1.12522673
36CSNK1G31.10421968
37GRK51.05532286
38PRKCG1.05259882
39CAMK2A1.02337922
40BCR1.01543410
41PAK30.99334969
42CAMK2B0.98980383
43CDK180.95930461
44CDK140.93371716
45MARK20.93065171
46CDK150.92814518
47OXSR10.90641833
48LATS20.89602163
49BMPR1B0.86040553
50CSNK1A1L0.85596789
51AKT30.84707777
52PRKCH0.82180478
53MUSK0.81542352
54CDK11A0.81227374
55GRK70.80483077
56TYRO30.80065479
57CDK190.79897853
58PRKCE0.77121148
59SGK20.76818114
60CSNK1G10.74207977
61STK390.72747489
62EPHB20.72387909
63DAPK10.69930282
64FGR0.67014671
65CAMK1G0.66633092
66FES0.65132124
67ROCK20.63144360
68PRKCZ0.61654719
69MAP3K60.60497622
70ADRBK10.59397802
71FGFR20.58507675
72RPS6KA20.57955264
73NME10.57528330
74MAPK120.57158952
75SIK30.56767132
76MAPK150.55929911
77CAMK2D0.55084433
78SGK10.54435807
79STK110.51305746
80ROCK10.51080835
81CAMK40.50151318
82ERBB20.48821986
83FRK0.48686996
84ADRBK20.46707067
85ICK0.45649340
86CAMKK10.45442621
87PRKD30.44943401
88MAPK100.44678510
89EPHA30.44310703
90CSNK1D0.44173731
91PRKG10.44088384
92ARAF0.42583125
93FYN0.41967115
94MAPK90.41216303
95CAMK2G0.40675650
96YES10.39824943
97CAMKK20.39459406
98CCNB10.38615645
99RET0.38195523
100BMPR20.38086374
101WNK40.37815583
102KSR20.37270606
103PRKCB0.37016010
104CSNK1E0.36713287
105RPS6KA30.36577657
106SGK30.36350166
107PRKACA0.36164216
108CDK30.34373026
109CDC42BPA0.33919337
110PRKACB0.32918641
111MAPK80.32523363
112DYRK1B0.31760645
113MAPKAPK50.31659551
114CAMK10.30947216
115INSRR0.30657186
116MAPK40.30543172
117DMPK0.30354817
118WNK10.29033092
119PRKDC0.28022556

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94121653
2Synaptic vesicle cycle_Homo sapiens_hsa047212.91455993
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73670582
4GABAergic synapse_Homo sapiens_hsa047272.71108483
5Olfactory transduction_Homo sapiens_hsa047402.51663099
6Glutamatergic synapse_Homo sapiens_hsa047242.50816256
7Circadian entrainment_Homo sapiens_hsa047132.43586573
8Morphine addiction_Homo sapiens_hsa050322.42108739
9Dopaminergic synapse_Homo sapiens_hsa047282.23374052
10Serotonergic synapse_Homo sapiens_hsa047262.19358305
11Axon guidance_Homo sapiens_hsa043602.13103750
12Amphetamine addiction_Homo sapiens_hsa050312.07524169
13Taste transduction_Homo sapiens_hsa047422.04170925
14Long-term potentiation_Homo sapiens_hsa047202.02422493
15Phototransduction_Homo sapiens_hsa047441.97902333
16Cholinergic synapse_Homo sapiens_hsa047251.92902642
17Cocaine addiction_Homo sapiens_hsa050301.88295129
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76894796
19Long-term depression_Homo sapiens_hsa047301.74993995
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71157004
21Insulin secretion_Homo sapiens_hsa049111.70160453
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64233796
23Salivary secretion_Homo sapiens_hsa049701.63025295
24Renin secretion_Homo sapiens_hsa049241.54783011
25Collecting duct acid secretion_Homo sapiens_hsa049661.53397185
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47373587
27Gap junction_Homo sapiens_hsa045401.44964387
28Gastric acid secretion_Homo sapiens_hsa049711.42809702
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40950300
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38098661
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36113685
32Oxytocin signaling pathway_Homo sapiens_hsa049211.34195220
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32757482
34Cardiac muscle contraction_Homo sapiens_hsa042601.29353249
35Calcium signaling pathway_Homo sapiens_hsa040201.28315389
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25515595
37Oxidative phosphorylation_Homo sapiens_hsa001901.24633280
38GnRH signaling pathway_Homo sapiens_hsa049121.18249218
39Vibrio cholerae infection_Homo sapiens_hsa051101.15016021
40Alzheimers disease_Homo sapiens_hsa050101.13601013
41ErbB signaling pathway_Homo sapiens_hsa040121.11780730
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11016346
43Melanogenesis_Homo sapiens_hsa049161.07545519
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06296507
45* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04400576
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03571159
47Parkinsons disease_Homo sapiens_hsa050121.03304444
48cAMP signaling pathway_Homo sapiens_hsa040241.00885644
49Estrogen signaling pathway_Homo sapiens_hsa049150.97238245
50Alcoholism_Homo sapiens_hsa050340.88084526
51Type II diabetes mellitus_Homo sapiens_hsa049300.86561600
52Glioma_Homo sapiens_hsa052140.83951361
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83364460
54Wnt signaling pathway_Homo sapiens_hsa043100.81713790
55Dilated cardiomyopathy_Homo sapiens_hsa054140.80133896
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79801693
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78104922
58Bile secretion_Homo sapiens_hsa049760.77804514
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76883033
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76718179
61Huntingtons disease_Homo sapiens_hsa050160.76193136
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.73579056
63Renal cell carcinoma_Homo sapiens_hsa052110.70217740
64MAPK signaling pathway_Homo sapiens_hsa040100.69130163
65Ras signaling pathway_Homo sapiens_hsa040140.69018879
66Hedgehog signaling pathway_Homo sapiens_hsa043400.66917472
67Colorectal cancer_Homo sapiens_hsa052100.66743400
68Endometrial cancer_Homo sapiens_hsa052130.66365011
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65836167
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64800495
71Oocyte meiosis_Homo sapiens_hsa041140.64498650
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.64478721
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62918754
74Dorso-ventral axis formation_Homo sapiens_hsa043200.62613782
75Steroid biosynthesis_Homo sapiens_hsa001000.61965975
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61694135
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58849523
78Choline metabolism in cancer_Homo sapiens_hsa052310.58809736
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58513363
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.52911491
81Ovarian steroidogenesis_Homo sapiens_hsa049130.50010816
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49929552
83Thyroid hormone synthesis_Homo sapiens_hsa049180.49568500
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49324804
85Pancreatic secretion_Homo sapiens_hsa049720.48996676
86Ether lipid metabolism_Homo sapiens_hsa005650.48704763
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.46350562
88Rap1 signaling pathway_Homo sapiens_hsa040150.45496469
89Phagosome_Homo sapiens_hsa041450.45374517
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44728999
91Butanoate metabolism_Homo sapiens_hsa006500.43529664
92Basal cell carcinoma_Homo sapiens_hsa052170.38699911
93Tight junction_Homo sapiens_hsa045300.38563654
94Circadian rhythm_Homo sapiens_hsa047100.37618270
95VEGF signaling pathway_Homo sapiens_hsa043700.36735389
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36119187
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35969482
98Prolactin signaling pathway_Homo sapiens_hsa049170.34491860
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34292661
100Melanoma_Homo sapiens_hsa052180.32904552
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32672079
102AMPK signaling pathway_Homo sapiens_hsa041520.32437957
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31631668
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31619376
105Endocytosis_Homo sapiens_hsa041440.31557778
106Insulin signaling pathway_Homo sapiens_hsa049100.31084678
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31051395
108beta-Alanine metabolism_Homo sapiens_hsa004100.30870811
109Glucagon signaling pathway_Homo sapiens_hsa049220.30708504
110Hippo signaling pathway_Homo sapiens_hsa043900.30595452
111Nitrogen metabolism_Homo sapiens_hsa009100.30445136
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30299552
113Histidine metabolism_Homo sapiens_hsa003400.30271469
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29054031

Most similar genes based on co-expression Upload to Enrichr

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