NCAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.37812892
2postsynaptic membrane organization (GO:0001941)6.24680127
3vocalization behavior (GO:0071625)5.77376408
4presynaptic membrane assembly (GO:0097105)5.75342437
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.64842929
6neurotransmitter-gated ion channel clustering (GO:0072578)5.45591391
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28426928
8protein localization to synapse (GO:0035418)5.07827184
9locomotory exploration behavior (GO:0035641)5.02602626
10presynaptic membrane organization (GO:0097090)4.99242132
11pyrimidine nucleobase catabolic process (GO:0006208)4.85548158
12regulation of glutamate receptor signaling pathway (GO:1900449)4.84006727
13axon ensheathment in central nervous system (GO:0032291)4.78904869
14central nervous system myelination (GO:0022010)4.78904869
15cerebral cortex radially oriented cell migration (GO:0021799)4.62998778
16layer formation in cerebral cortex (GO:0021819)4.57309381
17auditory behavior (GO:0031223)4.47203448
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.42143359
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.37513318
20dendritic spine morphogenesis (GO:0060997)4.36906799
21exploration behavior (GO:0035640)4.28210766
22establishment of mitochondrion localization (GO:0051654)4.25844121
23synaptic vesicle exocytosis (GO:0016079)4.25193206
24neuron recognition (GO:0008038)4.24709405
25central nervous system projection neuron axonogenesis (GO:0021952)4.18002524
26positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.16764431
27response to auditory stimulus (GO:0010996)4.12430993
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08794227
29neurotransmitter uptake (GO:0001504)4.06890690
30synaptic transmission, glutamatergic (GO:0035249)4.06887746
31dendrite morphogenesis (GO:0048813)4.04879638
32axonal fasciculation (GO:0007413)4.03982200
33glutamate receptor signaling pathway (GO:0007215)4.03969006
34synaptic vesicle maturation (GO:0016188)4.02096198
35glutamate secretion (GO:0014047)3.98915196
36sodium ion export (GO:0071436)3.97659746
37positive regulation of synapse assembly (GO:0051965)3.97201298
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.94215609
39gamma-aminobutyric acid transport (GO:0015812)3.93568897
40regulation of synaptic vesicle exocytosis (GO:2000300)3.93252914
41potassium ion import (GO:0010107)3.91954091
42oligodendrocyte differentiation (GO:0048709)3.88902982
43cerebellar granule cell differentiation (GO:0021707)3.87192254
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86349322
45innervation (GO:0060384)3.85721809
46regulation of neuronal synaptic plasticity (GO:0048168)3.81844669
47positive regulation of synapse maturation (GO:0090129)3.81292941
48prepulse inhibition (GO:0060134)3.77263455
49nucleobase catabolic process (GO:0046113)3.75780278
50mechanosensory behavior (GO:0007638)3.75744819
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.70780677
52proline transport (GO:0015824)3.65748251
53astrocyte differentiation (GO:0048708)3.63156988
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.56890328
55* regulation of synapse structural plasticity (GO:0051823)3.56397587
56cell migration in hindbrain (GO:0021535)3.56324105
57potassium ion homeostasis (GO:0055075)3.54012851
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.53438644
59positive regulation of membrane potential (GO:0045838)3.52566817
60neuron-neuron synaptic transmission (GO:0007270)3.49659179
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48817860
62synapse assembly (GO:0007416)3.45450170
63regulation of dendritic spine morphogenesis (GO:0061001)3.44703176
64regulation of respiratory system process (GO:0044065)3.43815945
65regulation of synaptic vesicle transport (GO:1902803)3.42599566
66positive regulation of dendritic spine development (GO:0060999)3.39990312
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38567295
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37400598
69negative regulation of dendrite development (GO:2000171)3.37155893
70L-amino acid import (GO:0043092)3.35461275
71neurotransmitter secretion (GO:0007269)3.34804032
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.33813539
73acidic amino acid transport (GO:0015800)3.33754207
74long-term synaptic potentiation (GO:0060291)3.28197681
75photoreceptor cell differentiation (GO:0046530)3.26139482
76eye photoreceptor cell differentiation (GO:0001754)3.26139482
77central nervous system neuron axonogenesis (GO:0021955)3.25818115
78hippocampus development (GO:0021766)3.24571207
79establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24537304
80mitochondrion transport along microtubule (GO:0047497)3.24537304
81negative regulation of oligodendrocyte differentiation (GO:0048715)3.23861230
82regulation of postsynaptic membrane potential (GO:0060078)3.22487424
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22170488
84regulation of synapse assembly (GO:0051963)3.21704518
85regulation of synapse maturation (GO:0090128)3.17508376
86cellular response to cholesterol (GO:0071397)3.16617253
87startle response (GO:0001964)3.15961060
88axon regeneration (GO:0031103)3.15505769
89negative regulation of sodium ion transport (GO:0010766)3.14694771
90regulation of dendritic spine development (GO:0060998)3.12962669
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12472010
92regulation of synaptic plasticity (GO:0048167)3.12364276
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11555063
94amino acid import (GO:0043090)3.11295787
95alanine transport (GO:0032328)3.11042141
96transmission of nerve impulse (GO:0019226)3.10608282
97long-term memory (GO:0007616)3.09897927
98regulation of respiratory gaseous exchange (GO:0043576)3.09713564
99learning (GO:0007612)3.09584783
100glial cell proliferation (GO:0014009)3.09200036
101cell communication by electrical coupling (GO:0010644)3.06377318
102negative regulation of neurotransmitter transport (GO:0051589)3.04765987
103* dermatan sulfate biosynthetic process (GO:0030208)3.04476380
104negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02038910
105* regulation of synapse organization (GO:0050807)3.00087923
106glial cell differentiation (GO:0010001)2.99435766
107cellular sodium ion homeostasis (GO:0006883)2.97164527
108neuron projection regeneration (GO:0031102)2.96941322
109negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96320080
110synapse organization (GO:0050808)2.95517460
111L-glutamate transport (GO:0015813)2.95428330
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93866473
113cerebellar Purkinje cell layer development (GO:0021680)2.93864858
114dendrite development (GO:0016358)2.93720478
115neuronal ion channel clustering (GO:0045161)2.93438634
116neuronal action potential propagation (GO:0019227)2.92401465
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92197160
118cellular potassium ion homeostasis (GO:0030007)2.91382776
119negative regulation of astrocyte differentiation (GO:0048712)2.90466876
120forebrain neuron differentiation (GO:0021879)2.89363440
121neuromuscular synaptic transmission (GO:0007274)2.88481081
122C4-dicarboxylate transport (GO:0015740)2.87684527
123regulation of neurotransmitter secretion (GO:0046928)2.83876050
124positive regulation of neurotransmitter secretion (GO:0001956)2.83277855
125membrane hyperpolarization (GO:0060081)2.81308568
126negative regulation of neurotransmitter secretion (GO:0046929)2.80038685
127gamma-aminobutyric acid signaling pathway (GO:0007214)2.78582938
128dendritic spine organization (GO:0097061)2.78062321
129membrane assembly (GO:0071709)2.73336974
130positive regulation of synaptic transmission (GO:0050806)2.72426560
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71358657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29609878
2GBX2_23144817_ChIP-Seq_PC3_Human3.85061586
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19982362
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12883489
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03349391
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.92338303
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.82418659
8AR_21572438_ChIP-Seq_LNCaP_Human2.78049281
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75702380
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74738154
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74738154
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66611518
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59107286
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.53678574
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50794809
16REST_21632747_ChIP-Seq_MESCs_Mouse2.44267601
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.38467832
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37036082
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29934475
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26806591
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26630845
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13951616
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11590362
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09026127
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.05573168
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98850969
27DROSHA_22980978_ChIP-Seq_HELA_Human1.93507140
28* RARB_27405468_Chip-Seq_BRAIN_Mouse1.89639175
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.89464931
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88750336
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85024860
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76121525
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75361135
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68630306
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66828168
36TAF15_26573619_Chip-Seq_HEK293_Human1.62514403
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61550475
38P300_19829295_ChIP-Seq_ESCs_Human1.59341430
39SMAD4_21799915_ChIP-Seq_A2780_Human1.49879571
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.48369562
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46295710
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.45678893
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45640019
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45097388
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43678951
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43094940
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.41325540
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.40991139
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40744620
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.39124451
51ZNF274_21170338_ChIP-Seq_K562_Hela1.37308580
52* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35300338
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.35150280
54RNF2_27304074_Chip-Seq_NSC_Mouse1.34382731
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31820261
56IGF1R_20145208_ChIP-Seq_DFB_Human1.31668548
57AR_25329375_ChIP-Seq_VCAP_Human1.28478012
58* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28343829
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.25196733
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20332953
61FUS_26573619_Chip-Seq_HEK293_Human1.18907577
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17643059
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17643059
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15925596
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15638672
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15314797
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.15027075
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13560450
69LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13376795
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13359335
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12578727
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.11965710
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.11452972
74AR_19668381_ChIP-Seq_PC3_Human1.10873445
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09924777
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09800728
77STAT3_23295773_ChIP-Seq_U87_Human1.08873234
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08719632
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.08460841
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07993692
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07711391
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07081618
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.06727307
84TP53_18474530_ChIP-ChIP_U2OS_Human1.06195974
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06173205
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06017956
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04513974
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02731134
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02690666
90SOX9_26525672_Chip-Seq_HEART_Mouse1.02254593
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02205737
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01885524
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.01610834
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01397746
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00605798
96RUNX2_22187159_ChIP-Seq_PCA_Human1.00068089
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99680210
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99204854
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98926161
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97994033
101BCAT_22108803_ChIP-Seq_LS180_Human0.96338341
102TCF4_23295773_ChIP-Seq_U87_Human0.96238188
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96188026
104* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96049238
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95401601
106AHR_22903824_ChIP-Seq_MCF-7_Human0.94555601
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.94010188
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93148586
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92522588
110RXR_22108803_ChIP-Seq_LS180_Human0.91549721
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91372164
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.88836069
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88600954
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88573021
115JUN_21703547_ChIP-Seq_K562_Human0.87415392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37233531
2MP0003880_abnormal_central_pattern4.35360178
3* MP0003635_abnormal_synaptic_transmissio3.58665352
4MP0004270_analgesia3.31170146
5MP0000778_abnormal_nervous_system3.15853910
6MP0002063_abnormal_learning/memory/cond3.15258487
7MP0005423_abnormal_somatic_nervous3.00217799
8MP0009745_abnormal_behavioral_response2.86157573
9MP0004858_abnormal_nervous_system2.83194130
10MP0002572_abnormal_emotion/affect_behav2.61919225
11MP0001968_abnormal_touch/_nociception2.55666849
12MP0001486_abnormal_startle_reflex2.51417774
13MP0002064_seizures2.50908859
14MP0003136_yellow_coat_color2.43252099
15MP0002734_abnormal_mechanical_nocicepti2.27404155
16MP0002736_abnormal_nociception_after2.17066652
17MP0001984_abnormal_olfaction2.11764710
18MP0009046_muscle_twitch2.10621194
19MP0002557_abnormal_social/conspecific_i2.09317721
20MP0004885_abnormal_endolymph1.95143473
21MP0005646_abnormal_pituitary_gland1.91290926
22MP0002733_abnormal_thermal_nociception1.87009420
23MP0002067_abnormal_sensory_capabilities1.86865973
24MP0002184_abnormal_innervation1.85621412
25MP0002272_abnormal_nervous_system1.83725495
26MP0001440_abnormal_grooming_behavior1.78970581
27MP0001188_hyperpigmentation1.78315761
28MP0009780_abnormal_chondrocyte_physiolo1.77608119
29MP0002735_abnormal_chemical_nociception1.76055319
30MP0001529_abnormal_vocalization1.67945075
31MP0005645_abnormal_hypothalamus_physiol1.66789142
32MP0006276_abnormal_autonomic_nervous1.66028204
33MP0000955_abnormal_spinal_cord1.64849154
34MP0001970_abnormal_pain_threshold1.62712657
35MP0004811_abnormal_neuron_physiology1.62031721
36MP0002882_abnormal_neuron_morphology1.56017258
37MP0006292_abnormal_olfactory_placode1.55945073
38MP0008569_lethality_at_weaning1.52814545
39MP0000631_abnormal_neuroendocrine_gland1.51231762
40MP0005386_behavior/neurological_phenoty1.49892155
41MP0004924_abnormal_behavior1.49892155
42MP0005499_abnormal_olfactory_system1.49644829
43MP0005394_taste/olfaction_phenotype1.49644829
44MP0002152_abnormal_brain_morphology1.47213188
45MP0003329_amyloid_beta_deposits1.45787759
46MP0001502_abnormal_circadian_rhythm1.44292228
47MP0002653_abnormal_ependyma_morphology1.39416431
48MP0005409_darkened_coat_color1.36578336
49MP0008789_abnormal_olfactory_epithelium1.36406461
50MP0003122_maternal_imprinting1.35039741
51MP0003634_abnormal_glial_cell1.34041464
52MP0001905_abnormal_dopamine_level1.29224514
53MP0002822_catalepsy1.28948846
54MP0002066_abnormal_motor_capabilities/c1.27650877
55MP0001501_abnormal_sleep_pattern1.26386551
56MP0009379_abnormal_foot_pigmentation1.26311256
57MP0002638_abnormal_pupillary_reflex1.23923362
58MP0003690_abnormal_glial_cell1.23292859
59MP0004742_abnormal_vestibular_system1.21599442
60MP0000049_abnormal_middle_ear1.16488607
61MP0000026_abnormal_inner_ear1.13496543
62MP0003861_abnormal_nervous_system1.12529829
63MP0001485_abnormal_pinna_reflex1.12491916
64MP0005171_absent_coat_pigmentation1.11352295
65MP0004142_abnormal_muscle_tone1.11336582
66MP0003633_abnormal_nervous_system1.09731094
67MP0001963_abnormal_hearing_physiology1.07911654
68MP0002751_abnormal_autonomic_nervous1.05181467
69MP0000569_abnormal_digit_pigmentation1.04202911
70MP0003938_abnormal_ear_development1.01868298
71MP0002249_abnormal_larynx_morphology1.01806213
72MP0002752_abnormal_somatic_nervous1.00275330
73MP0003631_nervous_system_phenotype0.99135974
74MP0005551_abnormal_eye_electrophysiolog0.97841063
75MP0002909_abnormal_adrenal_gland0.97645698
76MP0001177_atelectasis0.97460770
77MP0000534_abnormal_ureter_morphology0.94968281
78MP0004133_heterotaxia0.92862734
79MP0005167_abnormal_blood-brain_barrier0.91901600
80MP0003121_genomic_imprinting0.90301354
81MP0003879_abnormal_hair_cell0.88479137
82MP0000579_abnormal_nail_morphology0.88218049
83MP0003183_abnormal_peptide_metabolism0.86996299
84MP0000015_abnormal_ear_pigmentation0.85439532
85MP0003632_abnormal_nervous_system0.83617744
86MP0003787_abnormal_imprinting0.82883656
87MP0002069_abnormal_eating/drinking_beha0.82814410
88MP0002233_abnormal_nose_morphology0.81512162
89MP0005248_abnormal_Harderian_gland0.80506309
90MP0001299_abnormal_eye_distance/0.77969419
91MP0005253_abnormal_eye_physiology0.77511390
92MP0003137_abnormal_impulse_conducting0.77131675
93MP0001986_abnormal_taste_sensitivity0.76751819
94MP0006072_abnormal_retinal_apoptosis0.73220391
95MP0003119_abnormal_digestive_system0.73170164
96MP0003283_abnormal_digestive_organ0.73116185
97MP0005391_vision/eye_phenotype0.72830745
98MP0002229_neurodegeneration0.71637229
99MP0001943_abnormal_respiration0.70612213
100MP0003942_abnormal_urinary_system0.68944767
101MP0003755_abnormal_palate_morphology0.67446504
102MP0009250_abnormal_appendicular_skeleto0.66896903
103MP0003890_abnormal_embryonic-extraembry0.66619520
104MP0005195_abnormal_posterior_eye0.65703925
105MP0002081_perinatal_lethality0.64743992
106MP0000920_abnormal_myelination0.64736231
107MP0002234_abnormal_pharynx_morphology0.64678017
108MP0005187_abnormal_penis_morphology0.63925602
109MP0010770_preweaning_lethality0.63367775
110MP0002082_postnatal_lethality0.63367775
111MP0002116_abnormal_craniofacial_bone0.62146189
112MP0010769_abnormal_survival0.62141890
113MP0000566_synostosis0.61034605
114MP0002089_abnormal_postnatal_growth/wei0.59963852

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.63257953
2Myokymia (HP:0002411)5.11891121
3Epileptic encephalopathy (HP:0200134)4.41570951
4Megalencephaly (HP:0001355)4.39476772
5Progressive cerebellar ataxia (HP:0002073)4.09158498
6Focal seizures (HP:0007359)3.96046908
7Hyperventilation (HP:0002883)3.86586827
8Broad-based gait (HP:0002136)3.38829943
9Excessive salivation (HP:0003781)3.29920976
10Drooling (HP:0002307)3.29920976
11Hemiparesis (HP:0001269)3.26297142
12Peripheral hypomyelination (HP:0007182)3.14202858
13Visual hallucinations (HP:0002367)3.05000004
14Oligodactyly (hands) (HP:0001180)2.89448308
15Split foot (HP:0001839)2.89257083
16Obstructive sleep apnea (HP:0002870)2.87374631
17Polyphagia (HP:0002591)2.86071399
18Febrile seizures (HP:0002373)2.85752679
19Aplasia involving bones of the upper limbs (HP:0009823)2.84816129
20Aplasia of the phalanges of the hand (HP:0009802)2.84816129
21Aplasia involving bones of the extremities (HP:0009825)2.84816129
22Supranuclear gaze palsy (HP:0000605)2.83985307
23Genetic anticipation (HP:0003743)2.82224298
24Abnormality of the diencephalon (HP:0010662)2.81144335
25Abnormal eating behavior (HP:0100738)2.71543611
26Limb dystonia (HP:0002451)2.66859542
27Mutism (HP:0002300)2.65925670
28Action tremor (HP:0002345)2.64860031
29Ankle clonus (HP:0011448)2.62796362
30Dysdiadochokinesis (HP:0002075)2.62317648
31Abnormality of the 4th metacarpal (HP:0010012)2.62241074
32Abnormality of binocular vision (HP:0011514)2.59628880
33Diplopia (HP:0000651)2.59628880
34Cortical dysplasia (HP:0002539)2.59371116
35Neurofibrillary tangles (HP:0002185)2.57348902
36Epileptiform EEG discharges (HP:0011182)2.56151909
37Generalized tonic-clonic seizures (HP:0002069)2.53048961
38Morphological abnormality of the inner ear (HP:0011390)2.52955227
39Truncal ataxia (HP:0002078)2.51388054
40Absence seizures (HP:0002121)2.49087992
41Gaze-evoked nystagmus (HP:0000640)2.48127686
42Urinary bladder sphincter dysfunction (HP:0002839)2.47291881
43EEG with generalized epileptiform discharges (HP:0011198)2.46686779
44Oligodactyly (HP:0012165)2.44777312
45Hypsarrhythmia (HP:0002521)2.41478478
46Dialeptic seizures (HP:0011146)2.39555049
47Lissencephaly (HP:0001339)2.38985139
48Retinal dysplasia (HP:0007973)2.37391770
49Stereotypic behavior (HP:0000733)2.35937676
50Depression (HP:0000716)2.35924993
51Poor eye contact (HP:0000817)2.35772917
52Amblyopia (HP:0000646)2.34692685
53Absent speech (HP:0001344)2.32249009
54Hepatoblastoma (HP:0002884)2.29831021
55Atonic seizures (HP:0010819)2.28967527
56Progressive inability to walk (HP:0002505)2.26278063
57Pachygyria (HP:0001302)2.26161385
58Cerebral inclusion bodies (HP:0100314)2.20834025
59Abnormality of salivation (HP:0100755)2.18912650
60Impaired vibration sensation in the lower limbs (HP:0002166)2.18554185
61Sleep apnea (HP:0010535)2.18341413
62Anxiety (HP:0000739)2.16078966
63Protruding tongue (HP:0010808)2.15259736
64Inability to walk (HP:0002540)2.14690676
65Fibular hypoplasia (HP:0003038)2.14454196
66Intention tremor (HP:0002080)2.14366827
67Increased circulating renin level (HP:0000848)2.14132650
68Hemiplegia (HP:0002301)2.09876835
69Amyotrophic lateral sclerosis (HP:0007354)2.06849383
70Impaired social interactions (HP:0000735)2.06509587
71Abnormal social behavior (HP:0012433)2.06509587
72Fetal akinesia sequence (HP:0001989)2.05546158
73Akinesia (HP:0002304)2.04618883
74True hermaphroditism (HP:0010459)2.03556075
75Septo-optic dysplasia (HP:0100842)2.03236142
76Blue irides (HP:0000635)2.02799703
77Short 4th metacarpal (HP:0010044)2.02785901
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02785901
79Degeneration of the lateral corticospinal tracts (HP:0002314)1.99665925
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99665925
81Hypoplasia of the brainstem (HP:0002365)1.98443540
82Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98443540
83Cutaneous finger syndactyly (HP:0010554)1.98067366
84Gait imbalance (HP:0002141)1.97440342
85Lower limb muscle weakness (HP:0007340)1.96266043
86Pheochromocytoma (HP:0002666)1.95850633
87Agitation (HP:0000713)1.95731735
88Renal hypoplasia (HP:0000089)1.95259525
89Specific learning disability (HP:0001328)1.95068528
90Abnormality of the corticospinal tract (HP:0002492)1.94902810
91Dysmetria (HP:0001310)1.91571354
92Bronchomalacia (HP:0002780)1.90735460
93Aqueductal stenosis (HP:0002410)1.89451765
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85445667
95Scanning speech (HP:0002168)1.85261168
96Papilledema (HP:0001085)1.84356588
97Focal dystonia (HP:0004373)1.83642107
98Anomalous pulmonary venous return (HP:0010772)1.82890668
99Rib fusion (HP:0000902)1.82697536
100Autism (HP:0000717)1.82347120
101Synostosis involving the elbow (HP:0003938)1.82270115
102Humeroradial synostosis (HP:0003041)1.82270115
103Torticollis (HP:0000473)1.81906990
104Spastic tetraparesis (HP:0001285)1.78846705
105Urinary urgency (HP:0000012)1.78747749
106Alacrima (HP:0000522)1.77514709
107Optic nerve hypoplasia (HP:0000609)1.77217264
108Palpebral edema (HP:0100540)1.77043906
109Morphological abnormality of the pyramidal tract (HP:0002062)1.76839221
110Cutaneous syndactyly (HP:0012725)1.76734392
111Spastic tetraplegia (HP:0002510)1.76101163
112Intestinal atresia (HP:0011100)1.76085048
113Thickened helices (HP:0000391)1.75726384
114Morphological abnormality of the middle ear (HP:0008609)1.75374127
115Sporadic (HP:0003745)1.73941920
116Neuroendocrine neoplasm (HP:0100634)1.73810663
117Anophthalmia (HP:0000528)1.73512650
118Absent septum pellucidum (HP:0001331)1.72045638
119Type II lissencephaly (HP:0007260)1.71856536
120Impaired smooth pursuit (HP:0007772)1.71547992
121Relative macrocephaly (HP:0004482)1.71009409
122Gastroesophageal reflux (HP:0002020)1.70344341
123Hypoplasia of the corpus callosum (HP:0002079)1.70125486
124Gastrointestinal atresia (HP:0002589)1.69403811
125Aplasia/Hypoplasia of the fibula (HP:0006492)1.69109081
126Heterochromia iridis (HP:0001100)1.68484416
127Spastic gait (HP:0002064)1.68471327
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.68337039
129Impaired vibratory sensation (HP:0002495)1.66382405
130Inappropriate behavior (HP:0000719)1.65671190
131Insomnia (HP:0100785)1.63964810
132Open mouth (HP:0000194)1.63659518
133Abnormality of the labia minora (HP:0012880)1.63200491
134Abnormality of the lower motor neuron (HP:0002366)1.62742646
135Turricephaly (HP:0000262)1.61674050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.64630054
2MARK15.35973682
3EPHA43.65683421
4NTRK23.20068702
5TNIK2.87778028
6NTRK32.77689297
7MAPK152.62194200
8MKNK22.35182897
9MAPK132.27367715
10MAP2K72.20665115
11MINK12.08900596
12PHKG12.00355514
13PHKG22.00355514
14MAP3K91.94466202
15MAP3K41.93681427
16PRPF4B1.85352291
17KSR11.76912234
18DAPK21.67029067
19DYRK21.62038490
20PAK61.60141102
21SGK21.55986638
22ERBB31.54506850
23SGK4941.41567716
24SGK2231.41567716
25PLK21.38259337
26LMTK21.35685266
27CDK51.34154599
28DYRK1A1.28477545
29PINK11.27331513
30MKNK11.22021994
31PRKD31.21592630
32SIK21.16016789
33UHMK11.15353626
34PRKCG1.12622026
35CCNB11.10278602
36CAMKK11.10149542
37EPHB21.08675622
38CDK191.07918982
39SGK31.03078509
40CSNK1G20.98567848
41MAP3K120.98090298
42TYRO30.95588131
43CDK180.93736671
44EPHA30.91201723
45MUSK0.91099729
46NTRK10.90849679
47DAPK10.89840911
48CDK150.88784295
49CDK140.87090528
50FES0.81484922
51CAMK2A0.80779215
52MAP2K40.79976466
53PDGFRA0.78720287
54CDK11A0.78581183
55PAK30.77940036
56TSSK60.77093244
57STK240.76635000
58DDR20.70430825
59FGR0.70215388
60CAMK1G0.69558278
61SIK30.68426562
62RPS6KA20.68240573
63CAMK2G0.67641528
64NEK60.66946944
65SGK10.64985769
66PKN10.64620319
67BMPR20.62958247
68ROCK10.61771786
69CSNK1G30.61475549
70LIMK10.61340783
71MARK20.61295722
72CAMKK20.60080304
73CAMK1D0.59475764
74PRKCZ0.59396098
75CAMK2D0.58309196
76CAMK2B0.58003178
77PRKCH0.56162997
78LATS20.55870910
79STK110.55582419
80BMPR1B0.54036012
81KSR20.53540204
82MAPK100.53091839
83BCR0.51767585
84CSNK1A1L0.51732590
85PRKCE0.51685661
86GRK50.51679541
87IRAK20.51314437
88ROCK20.49774396
89RIPK40.48878477
90WNK30.47616421
91CSNK1D0.47025256
92ERBB40.47005429
93DYRK1B0.46026224
94CSNK1G10.41597000
95CAMK10.41345284
96ADRBK10.41286822
97FGFR20.40958312
98MAPK120.40298013
99AKT30.40018124
100PDGFRB0.39971632
101STK380.38589881
102YES10.38537632
103RPS6KA30.37148599
104CLK10.36568804
105TAOK10.34976514
106PNCK0.34814548
107MAPKAPK50.34235370
108CAMK40.34139883
109RET0.34123078
110FYN0.33504989
111RPS6KB10.32448237
112PRKDC0.32050983
113EPHB10.31136116
114CDK30.31082068
115CSNK1A10.30570870
116ERBB20.30105833
117RAF10.29467215
118PRKG10.28008988
119PRKACA0.27728493
120OXSR10.27602379
121CSNK1E0.27115917
122GSK3B0.25849438
123MAPK90.25425700
124MAPK40.24898942
125MAP4K20.24782030

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80277274
2Glutamatergic synapse_Homo sapiens_hsa047242.64987543
3GABAergic synapse_Homo sapiens_hsa047272.60386152
4Circadian entrainment_Homo sapiens_hsa047132.51126882
5Synaptic vesicle cycle_Homo sapiens_hsa047212.44367654
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44199660
7Olfactory transduction_Homo sapiens_hsa047402.40248227
8Morphine addiction_Homo sapiens_hsa050322.33033826
9Long-term potentiation_Homo sapiens_hsa047202.28126013
10Nitrogen metabolism_Homo sapiens_hsa009102.20884780
11Axon guidance_Homo sapiens_hsa043602.13370466
12Dopaminergic synapse_Homo sapiens_hsa047282.02178952
13Amphetamine addiction_Homo sapiens_hsa050311.97860020
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91756910
15Salivary secretion_Homo sapiens_hsa049701.82127733
16Cholinergic synapse_Homo sapiens_hsa047251.79009337
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73786361
18Insulin secretion_Homo sapiens_hsa049111.73242985
19Gastric acid secretion_Homo sapiens_hsa049711.72443712
20Cocaine addiction_Homo sapiens_hsa050301.66938657
21Long-term depression_Homo sapiens_hsa047301.66796050
22Serotonergic synapse_Homo sapiens_hsa047261.58013152
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56151773
24Renin secretion_Homo sapiens_hsa049241.56083353
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50768459
26Gap junction_Homo sapiens_hsa045401.49396986
27Taste transduction_Homo sapiens_hsa047421.47237590
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42365669
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39290629
30Oxytocin signaling pathway_Homo sapiens_hsa049211.39245656
31Calcium signaling pathway_Homo sapiens_hsa040201.38141782
32Melanogenesis_Homo sapiens_hsa049161.36397394
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33876150
34ErbB signaling pathway_Homo sapiens_hsa040121.25467076
35Glioma_Homo sapiens_hsa052141.25284926
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24669920
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23174006
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22077800
39Endometrial cancer_Homo sapiens_hsa052131.20537980
40cAMP signaling pathway_Homo sapiens_hsa040241.19602611
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19500356
42GnRH signaling pathway_Homo sapiens_hsa049121.13345755
43Notch signaling pathway_Homo sapiens_hsa043301.03633222
44Colorectal cancer_Homo sapiens_hsa052101.02828064
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01502446
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97964010
47Dorso-ventral axis formation_Homo sapiens_hsa043200.96594150
48Wnt signaling pathway_Homo sapiens_hsa043100.94221326
49Fatty acid biosynthesis_Homo sapiens_hsa000610.93749794
50Estrogen signaling pathway_Homo sapiens_hsa049150.92977175
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90672094
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90060483
53Basal cell carcinoma_Homo sapiens_hsa052170.88056548
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87450597
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83272802
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.83100773
57Phototransduction_Homo sapiens_hsa047440.81645596
58Vitamin B6 metabolism_Homo sapiens_hsa007500.81423619
59Fatty acid metabolism_Homo sapiens_hsa012120.80244249
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79600287
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.77589774
62Collecting duct acid secretion_Homo sapiens_hsa049660.76429408
63Hedgehog signaling pathway_Homo sapiens_hsa043400.68970736
64Type II diabetes mellitus_Homo sapiens_hsa049300.67588930
65Renal cell carcinoma_Homo sapiens_hsa052110.67025031
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66636719
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65712777
68Circadian rhythm_Homo sapiens_hsa047100.64961740
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.64786052
70Ras signaling pathway_Homo sapiens_hsa040140.64712749
71beta-Alanine metabolism_Homo sapiens_hsa004100.63803720
72Choline metabolism in cancer_Homo sapiens_hsa052310.63121105
73Rap1 signaling pathway_Homo sapiens_hsa040150.62280612
74Oocyte meiosis_Homo sapiens_hsa041140.61811413
75Cardiac muscle contraction_Homo sapiens_hsa042600.61305969
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61082822
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60938985
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60590600
79MAPK signaling pathway_Homo sapiens_hsa040100.59717466
80Alcoholism_Homo sapiens_hsa050340.58949392
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58221276
82Steroid biosynthesis_Homo sapiens_hsa001000.57452117
83Vibrio cholerae infection_Homo sapiens_hsa051100.57142403
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.56967832
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56689556
86Hippo signaling pathway_Homo sapiens_hsa043900.56519759
87Dilated cardiomyopathy_Homo sapiens_hsa054140.56445349
88Non-small cell lung cancer_Homo sapiens_hsa052230.54025537
89Pancreatic secretion_Homo sapiens_hsa049720.53042066
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49482768
91Butanoate metabolism_Homo sapiens_hsa006500.48700170
92PPAR signaling pathway_Homo sapiens_hsa033200.48492680
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48373542
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48310284
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48137078
96Melanoma_Homo sapiens_hsa052180.45770262
97Thyroid hormone synthesis_Homo sapiens_hsa049180.40928688
98Insulin signaling pathway_Homo sapiens_hsa049100.40502730
99Prion diseases_Homo sapiens_hsa050200.40060823
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39316891
101VEGF signaling pathway_Homo sapiens_hsa043700.38738022
102African trypanosomiasis_Homo sapiens_hsa051430.37406775
103AMPK signaling pathway_Homo sapiens_hsa041520.36523356
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36020618
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35630572
106Propanoate metabolism_Homo sapiens_hsa006400.34902951
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34264588
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33433508
109Bile secretion_Homo sapiens_hsa049760.32993298
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32363718
111Glucagon signaling pathway_Homo sapiens_hsa049220.32310630

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