NCAPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.98913146
2sister chromatid segregation (GO:0000819)6.15423755
3DNA replication-dependent nucleosome assembly (GO:0006335)6.04750834
4DNA replication-dependent nucleosome organization (GO:0034723)6.04750834
5DNA unwinding involved in DNA replication (GO:0006268)6.04486466
6mitotic sister chromatid segregation (GO:0000070)5.95947252
7nuclear pore complex assembly (GO:0051292)5.72322167
8protein localization to chromosome, centromeric region (GO:0071459)5.67228321
9chromatin assembly (GO:0031497)5.42781313
10nuclear pore organization (GO:0006999)5.30806310
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.03075550
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.83009030
13regulation of mitotic spindle organization (GO:0060236)4.77446513
14regulation of histone H3-K9 methylation (GO:0051570)4.73506236
15negative regulation of cell cycle G2/M phase transition (GO:1902750)4.71663472
16* mitotic chromosome condensation (GO:0007076)4.68215415
17DNA duplex unwinding (GO:0032508)4.62583216
18DNA geometric change (GO:0032392)4.58974878
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.57547569
20regulation of telomere maintenance via telomerase (GO:0032210)4.43307711
21chromatin assembly or disassembly (GO:0006333)4.25647689
22heterochromatin organization (GO:0070828)4.25120152
23regulation of translational fidelity (GO:0006450)4.23361233
24pore complex assembly (GO:0046931)4.22168252
25establishment of integrated proviral latency (GO:0075713)4.17151764
26DNA replication checkpoint (GO:0000076)4.11379571
27negative regulation of histone methylation (GO:0031061)4.09415506
28regulation of nuclear cell cycle DNA replication (GO:0033262)4.08013846
29daunorubicin metabolic process (GO:0044597)3.99844675
30polyketide metabolic process (GO:0030638)3.99844675
31doxorubicin metabolic process (GO:0044598)3.99844675
32pre-miRNA processing (GO:0031054)3.98398733
33establishment of chromosome localization (GO:0051303)3.90271062
34DNA replication initiation (GO:0006270)3.89074761
35DNA ligation (GO:0006266)3.87342059
36telomere maintenance via recombination (GO:0000722)3.82088268
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.78184775
38histone H4-K5 acetylation (GO:0043981)3.72681341
39histone H4-K8 acetylation (GO:0043982)3.72681341
40mitotic nuclear envelope disassembly (GO:0007077)3.67378380
41* DNA conformation change (GO:0071103)3.64414833
42mitotic sister chromatid cohesion (GO:0007064)3.62210927
43* chromosome condensation (GO:0030261)3.61461939
44protein localization to chromosome (GO:0034502)3.60092161
45RNA stabilization (GO:0043489)3.58199453
46mRNA stabilization (GO:0048255)3.58199453
47formation of translation preinitiation complex (GO:0001731)3.55649217
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.54311552
49protein complex localization (GO:0031503)3.54279280
50nuclear envelope disassembly (GO:0051081)3.50066251
51membrane disassembly (GO:0030397)3.50066251
52nuclear envelope organization (GO:0006998)3.49942249
53negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.39931510
54kinetochore organization (GO:0051383)3.38781808
55nucleosome assembly (GO:0006334)3.38324202
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.37073257
57attachment of spindle microtubules to kinetochore (GO:0008608)3.35774037
58dosage compensation (GO:0007549)3.35699703
59V(D)J recombination (GO:0033151)3.34435359
60negative regulation of telomerase activity (GO:0051974)3.31838482
61chromosome segregation (GO:0007059)3.29689833
62mitotic spindle checkpoint (GO:0071174)3.29234903
63mitotic recombination (GO:0006312)3.28405040
64positive regulation of DNA-dependent DNA replication (GO:2000105)3.27990623
65nucleosome organization (GO:0034728)3.26696276
66regulation of sister chromatid segregation (GO:0033045)3.26347872
67regulation of mitotic sister chromatid separation (GO:0010965)3.26347872
68regulation of mitotic sister chromatid segregation (GO:0033047)3.26347872
69folic acid-containing compound biosynthetic process (GO:0009396)3.25059876
70DNA strand elongation involved in DNA replication (GO:0006271)3.24977988
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24681234
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24681234
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24681234
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.24681234
75negative regulation of sister chromatid segregation (GO:0033046)3.24681234
76translesion synthesis (GO:0019985)3.24617320
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24154115
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24154115
79histone H4-K12 acetylation (GO:0043983)3.23917054
80DNA topological change (GO:0006265)3.23512988
81mitotic spindle assembly checkpoint (GO:0007094)3.23173074
82maintenance of protein location in nucleus (GO:0051457)3.22910790
83negative regulation of epidermis development (GO:0045683)3.22281477
84DNA replication-independent nucleosome assembly (GO:0006336)3.22078301
85DNA replication-independent nucleosome organization (GO:0034724)3.22078301
86regulation of mammary gland epithelial cell proliferation (GO:0033599)3.18935353
87regulation of chromosome segregation (GO:0051983)3.18417443
88non-recombinational repair (GO:0000726)3.18208181
89double-strand break repair via nonhomologous end joining (GO:0006303)3.18208181
90cellular protein complex localization (GO:0034629)3.17965192
91DNA synthesis involved in DNA repair (GO:0000731)3.16809015
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.15084628
93histone H4-K16 acetylation (GO:0043984)3.15074270
94chromatin remodeling at centromere (GO:0031055)3.14924989
95positive regulation of chromosome segregation (GO:0051984)3.14515105
96somite rostral/caudal axis specification (GO:0032525)3.12246857
97CENP-A containing nucleosome assembly (GO:0034080)3.12109736
98positive regulation of histone H3-K4 methylation (GO:0051571)3.11117654
99negative regulation of mRNA processing (GO:0050686)3.11014147
100spindle assembly (GO:0051225)3.10754438
101establishment of viral latency (GO:0019043)3.10456636
102regulation of sister chromatid cohesion (GO:0007063)3.08933270
103* DNA packaging (GO:0006323)3.08121317
104spindle assembly checkpoint (GO:0071173)3.07126276
105microtubule depolymerization (GO:0007019)3.06885590
106spindle organization (GO:0007051)3.05702323
107DNA strand elongation (GO:0022616)3.05697286
108ATP-dependent chromatin remodeling (GO:0043044)3.02169893
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01176024
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01176024
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.01176024
112regulation of gene silencing (GO:0060968)3.01159506
113regulation of RNA export from nucleus (GO:0046831)3.01148748
114mitotic cytokinesis (GO:0000281)3.00492664
115regulation of centrosome cycle (GO:0046605)3.00450737
116protein export from nucleus (GO:0006611)2.98356846
117protein-DNA complex assembly (GO:0065004)2.98090045
118IMP biosynthetic process (GO:0006188)2.96814256
119positive regulation of histone deacetylation (GO:0031065)2.96766097
120establishment of mitotic spindle localization (GO:0040001)2.96239036
121protein-DNA complex subunit organization (GO:0071824)2.95314997
122spindle checkpoint (GO:0031577)2.94461760
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.94417811
124negative regulation of mRNA metabolic process (GO:1903312)2.94109659
125telomere maintenance via semi-conservative replication (GO:0032201)2.93018339
126regulation of gene silencing by RNA (GO:0060966)2.92825261
127regulation of posttranscriptional gene silencing (GO:0060147)2.92825261
128regulation of gene silencing by miRNA (GO:0060964)2.92825261
129rRNA transcription (GO:0009303)2.91118543
130meiotic chromosome segregation (GO:0045132)2.90853885
131telomere maintenance via telomere lengthening (GO:0010833)2.90367341
132* mitotic cell cycle (GO:0000278)2.89761015
133regulation of double-strand break repair (GO:2000779)2.89555525
134spindle assembly involved in mitosis (GO:0090307)2.89361564
135regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.85568065
136regulation of spindle organization (GO:0090224)2.84465847
137regulation of telomere maintenance (GO:0032204)2.83377910
138mitotic metaphase plate congression (GO:0007080)2.82730466
139regulation of centriole replication (GO:0046599)2.82694532
140negative regulation of chromosome segregation (GO:0051985)2.81643865
141metaphase plate congression (GO:0051310)2.80666542
142protein-DNA complex disassembly (GO:0032986)2.80602061
143nucleosome disassembly (GO:0006337)2.80602061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.24993781
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.02669835
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.74897940
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34484217
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.14008069
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.14008069
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.14008069
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.93720645
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.50388563
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.40421864
11MYC_22102868_ChIP-Seq_BL_Human2.28718496
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.28191563
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07834371
14* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06041814
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03305058
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.02614166
17E2F7_22180533_ChIP-Seq_HELA_Human10.4316492
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96784785
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.94858708
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92965318
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92573709
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87016781
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83395746
24SOX2_18555785_ChIP-Seq_MESCs_Mouse1.82019609
25AR_21909140_ChIP-Seq_LNCAP_Human1.81270672
26* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80318283
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71773353
28TCF3_18692474_ChIP-Seq_MESCs_Mouse1.68380460
29DCP1A_22483619_ChIP-Seq_HELA_Human1.65491335
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.60966486
31* TTF2_22483619_ChIP-Seq_HELA_Human1.58116530
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57277825
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54685447
34ZNF263_19887448_ChIP-Seq_K562_Human1.52949767
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52305547
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51104288
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47005380
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.45617732
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42797870
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.41589680
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40232272
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38135851
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38041851
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37509241
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36593168
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36084452
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35860944
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34714588
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34663452
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34366149
51CIITA_25753668_ChIP-Seq_RAJI_Human1.33171094
52* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32966625
53* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30317740
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29437926
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29391569
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28335449
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27199369
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.26384090
59GABP_19822575_ChIP-Seq_HepG2_Human1.26058613
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25974265
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25791443
62TCF7_22412390_ChIP-Seq_EML_Mouse1.24621772
63* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23378622
64VDR_21846776_ChIP-Seq_THP-1_Human1.22723609
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22520761
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20703613
67KDM5A_27292631_Chip-Seq_BREAST_Human1.17062592
68XRN2_22483619_ChIP-Seq_HELA_Human1.15796611
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15616284
70* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14459248
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.13605462
72* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12301432
73SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12074190
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10861956
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08860623
76* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08452654
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07249990
78TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07198909
79FOXP3_21729870_ChIP-Seq_TREG_Human1.07005029
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.05127012
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.02904899
82CHD1_26751641_Chip-Seq_LNCaP_Human1.01982219
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00987917
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00921799
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00580486
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00293845
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00225962
88CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99148776
89ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97119829
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97024596
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96980402
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96382484
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96181049
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95855886
95TFEB_21752829_ChIP-Seq_HELA_Human0.93988260
96* VDR_23849224_ChIP-Seq_CD4+_Human0.93921328
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93915630
98POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93841876
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92740302
100POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91602406
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91552952
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90836037
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90388893
104POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89910336
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.89846116
106* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89167008
107EST1_17652178_ChIP-ChIP_JURKAT_Human0.88921338
108E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87896710
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87765436
110CLOCK_20551151_ChIP-Seq_293T_Human0.87708204
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87524891
112NCOR1_26117541_ChIP-Seq_K562_Human0.87409256
113NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87270754
114* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87019732
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86820305
116IRF1_19129219_ChIP-ChIP_H3396_Human0.86818762
117* ELK1_19687146_ChIP-ChIP_HELA_Human0.86248460
118* SOX17_20123909_ChIP-Seq_XEN_Mouse0.85920981
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.85876252
120* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85504510
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85290909
122UTX_26944678_Chip-Seq_JUKART_Human0.83705500
123ATF3_27146783_Chip-Seq_COLON_Human0.83628328
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83495134
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83347351
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82560872
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81819110
128HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81640317
129GABP_17652178_ChIP-ChIP_JURKAT_Human0.81254185
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80993288
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80710541
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80619668
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79054127
134RACK7_27058665_Chip-Seq_MCF-7_Human0.78142462
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76188454
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75635844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.77457515
2MP0010094_abnormal_chromosome_stability3.66224279
3MP0003111_abnormal_nucleus_morphology3.30994547
4MP0004957_abnormal_blastocyst_morpholog3.28885638
5MP0010352_gastrointestinal_tract_polyps3.22913021
6MP0003077_abnormal_cell_cycle3.10535589
7MP0003705_abnormal_hypodermis_morpholog2.86471234
8MP0003890_abnormal_embryonic-extraembry2.77587546
9MP0003121_genomic_imprinting2.76948114
10MP0003693_abnormal_embryo_hatching2.46215933
11MP0004264_abnormal_extraembryonic_tissu2.31424320
12MP0000350_abnormal_cell_proliferation2.17794022
13MP0010307_abnormal_tumor_latency2.16677156
14MP0003123_paternal_imprinting2.10652620
15MP0001672_abnormal_embryogenesis/_devel2.05744731
16MP0005380_embryogenesis_phenotype2.05744731
17MP0010030_abnormal_orbit_morphology1.98470483
18MP0008007_abnormal_cellular_replicative1.97287772
19MP0001730_embryonic_growth_arrest1.97072581
20MP0003984_embryonic_growth_retardation1.90058438
21MP0002088_abnormal_embryonic_growth/wei1.89770191
22MP0002396_abnormal_hematopoietic_system1.83148393
23MP0003787_abnormal_imprinting1.77041412
24MP0002085_abnormal_embryonic_tissue1.76025227
25MP0008932_abnormal_embryonic_tissue1.75707457
26MP0002084_abnormal_developmental_patter1.73592592
27MP0003011_delayed_dark_adaptation1.72971058
28MP0002086_abnormal_extraembryonic_tissu1.70839485
29MP0009697_abnormal_copulation1.70674859
30MP0004185_abnormal_adipocyte_glucose1.69245235
31MP0004197_abnormal_fetal_growth/weight/1.68936188
32MP0003122_maternal_imprinting1.66699846
33MP0009672_abnormal_birth_weight1.63810529
34MP0005076_abnormal_cell_differentiation1.61991845
35MP0002254_reproductive_system_inflammat1.59709272
36MP0000678_abnormal_parathyroid_gland1.59491385
37MP0008058_abnormal_DNA_repair1.59397473
38MP0004233_abnormal_muscle_weight1.56860534
39MP0006292_abnormal_olfactory_placode1.56334597
40MP0001697_abnormal_embryo_size1.55657628
41MP0005394_taste/olfaction_phenotype1.52385486
42MP0005499_abnormal_olfactory_system1.52385486
43MP0001849_ear_inflammation1.50368768
44MP0000490_abnormal_crypts_of1.43208870
45MP0001293_anophthalmia1.41153416
46MP0002080_prenatal_lethality1.40855069
47MP0003283_abnormal_digestive_organ1.38094542
48MP0010234_abnormal_vibrissa_follicle1.37616424
49MP0002092_abnormal_eye_morphology1.37277270
50MP0005257_abnormal_intraocular_pressure1.34439471
51MP0004808_abnormal_hematopoietic_stem1.31776712
52MP0003938_abnormal_ear_development1.30310961
53MP0003937_abnormal_limbs/digits/tail_de1.29767131
54MP0005075_abnormal_melanosome_morpholog1.28900045
55MP0005451_abnormal_body_composition1.27663482
56MP0000313_abnormal_cell_death1.27033096
57MP0000703_abnormal_thymus_morphology1.23508952
58MP0000049_abnormal_middle_ear1.23467839
59MP0003935_abnormal_craniofacial_develop1.22859139
60MP0005623_abnormal_meninges_morphology1.17913472
61MP0001346_abnormal_lacrimal_gland1.16696261
62MP0008877_abnormal_DNA_methylation1.15922630
63MP0002019_abnormal_tumor_incidence1.14673648
64MP0001661_extended_life_span1.13159588
65MP0000537_abnormal_urethra_morphology1.10852472
66MP0000432_abnormal_head_morphology1.07187107
67MP0009703_decreased_birth_body1.05391526
68MP0008789_abnormal_olfactory_epithelium1.05323629
69MP0005501_abnormal_skin_physiology1.04288329
70MP0005621_abnormal_cell_physiology1.02140583
71MP0009278_abnormal_bone_marrow1.01782607
72MP0000733_abnormal_muscle_development1.01714351
73MP0003119_abnormal_digestive_system1.01427296
74MP0002925_abnormal_cardiovascular_devel1.01022981
75MP0002932_abnormal_joint_morphology0.99715893
76MP0000428_abnormal_craniofacial_morphol0.98935186
77MP0008770_decreased_survivor_rate0.98137623
78MP0005391_vision/eye_phenotype0.95791905
79MP0004858_abnormal_nervous_system0.95384060
80MP0003718_maternal_effect0.94491216
81MP0000569_abnormal_digit_pigmentation0.93754036
82MP0002697_abnormal_eye_size0.93523582
83MP0002332_abnormal_exercise_endurance0.91787215
84MP0002653_abnormal_ependyma_morphology0.90797427
85MP0002114_abnormal_axial_skeleton0.90047593
86MP0001348_abnormal_lacrimal_gland0.90019105
87MP0002722_abnormal_immune_system0.89669727
88MP0000566_synostosis0.89167780
89MP0006054_spinal_hemorrhage0.88652196
90MP0003786_premature_aging0.88146275
91MP0002233_abnormal_nose_morphology0.87857704
92MP0000358_abnormal_cell_content/0.87154630
93MP0003755_abnormal_palate_morphology0.86919634
94MP0003183_abnormal_peptide_metabolism0.86196261
95MP0003115_abnormal_respiratory_system0.85837244
96MP0009053_abnormal_anal_canal0.85676453
97MP0003385_abnormal_body_wall0.85464566
98MP0003941_abnormal_skin_development0.84519461
99MP0002398_abnormal_bone_marrow0.84049638
100MP0005023_abnormal_wound_healing0.82528571
101MP0003861_abnormal_nervous_system0.82330748
102MP0010678_abnormal_skin_adnexa0.81510589
103MP0002877_abnormal_melanocyte_morpholog0.81332416
104MP0002166_altered_tumor_susceptibility0.79908732
105MP0001286_abnormal_eye_development0.79583131
106MP0002060_abnormal_skin_morphology0.79441366
107MP0008961_abnormal_basal_metabolism0.79128570
108MP0002111_abnormal_tail_morphology0.78919549
109MP0000689_abnormal_spleen_morphology0.77238548
110MP0002009_preneoplasia0.76074693
111MP0003943_abnormal_hepatobiliary_system0.75983267
112MP0001915_intracranial_hemorrhage0.74394165
113MP0005384_cellular_phenotype0.74109902
114MP0000003_abnormal_adipose_tissue0.74022167
115MP0000383_abnormal_hair_follicle0.73419252
116MP0003942_abnormal_urinary_system0.73099121
117MP0002006_tumorigenesis0.72769358
118MP0002127_abnormal_cardiovascular_syste0.72527245
119MP0008438_abnormal_cutaneous_collagen0.72350097
120MP0002249_abnormal_larynx_morphology0.72267332
121MP0003763_abnormal_thymus_physiology0.71586503
122MP0002796_impaired_skin_barrier0.70633078
123MP0005171_absent_coat_pigmentation0.70492315
124MP0002210_abnormal_sex_determination0.70483187
125MP0003566_abnormal_cell_adhesion0.69430804
126MP0005409_darkened_coat_color0.69284952
127MP0002970_abnormal_white_adipose0.69050011
128MP0003221_abnormal_cardiomyocyte_apopto0.68717361
129MP0002075_abnormal_coat/hair_pigmentati0.68661669
130MP0002089_abnormal_postnatal_growth/wei0.68392457
131MP0003567_abnormal_fetal_cardiomyocyte0.68371756
132MP0001145_abnormal_male_reproductive0.67278268
133MP0003315_abnormal_perineum_morphology0.67145709
134MP0003453_abnormal_keratinocyte_physiol0.66536562
135MP0002938_white_spotting0.66286256
136MP0004272_abnormal_basement_membrane0.66010008
137MP0006035_abnormal_mitochondrial_morpho0.62422890
138MP0000762_abnormal_tongue_morphology0.61247525
139MP0001216_abnormal_epidermal_layer0.59548269

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)4.27892385
2Ependymoma (HP:0002888)4.21632146
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99644907
4Bilateral microphthalmos (HP:0007633)3.87808707
5Chromsome breakage (HP:0040012)3.75116884
6Abnormality of the lower motor neuron (HP:0002366)3.54642424
7Abnormality of the astrocytes (HP:0100707)3.48670928
8Astrocytoma (HP:0009592)3.48670928
9Rhabdomyosarcoma (HP:0002859)3.34540606
10Neoplasm of striated muscle (HP:0009728)3.23546789
11Hepatoblastoma (HP:0002884)3.20940922
12Volvulus (HP:0002580)3.16106558
13Impulsivity (HP:0100710)3.08883287
14Nephroblastoma (Wilms tumor) (HP:0002667)3.08513952
15Combined immunodeficiency (HP:0005387)2.93999569
16Rib fusion (HP:0000902)2.93997279
17Embryonal renal neoplasm (HP:0011794)2.86080522
18Reticulocytopenia (HP:0001896)2.77863965
19Multiple enchondromatosis (HP:0005701)2.76123196
20Preauricular skin tag (HP:0000384)2.74494649
21Abnormality of chromosome segregation (HP:0002916)2.73165940
22Cortical dysplasia (HP:0002539)2.67669343
23Skin tags (HP:0010609)2.67622425
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.66056506
25Increased nuchal translucency (HP:0010880)2.64342263
26Renal duplication (HP:0000075)2.63889150
27Birth length less than 3rd percentile (HP:0003561)2.63296909
28Insomnia (HP:0100785)2.63106654
29Glioma (HP:0009733)2.62189484
30Meckel diverticulum (HP:0002245)2.59761600
31Overlapping toe (HP:0001845)2.59087864
32Medulloblastoma (HP:0002885)2.56110474
33High anterior hairline (HP:0009890)2.51805331
34Abnormality of chromosome stability (HP:0003220)2.51772267
35Hypopigmentation of the fundus (HP:0007894)2.50818437
36Abnormality of the fingertips (HP:0001211)2.50408209
37Abnormality of the ileum (HP:0001549)2.48819505
38Deep philtrum (HP:0002002)2.35045557
39Abnormal lung lobation (HP:0002101)2.33756986
40Abnormality of the calcaneus (HP:0008364)2.30911709
4111 pairs of ribs (HP:0000878)2.29232473
42Progressive muscle weakness (HP:0003323)2.28973087
43Microvesicular hepatic steatosis (HP:0001414)2.28939737
44Large earlobe (HP:0009748)2.28651539
45Broad distal phalanx of finger (HP:0009836)2.27891928
46Small intestinal stenosis (HP:0012848)2.26474412
47Duodenal stenosis (HP:0100867)2.26474412
48Asymmetry of the thorax (HP:0001555)2.25598537
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22829122
50Progressive external ophthalmoplegia (HP:0000590)2.21619782
51Amyotrophic lateral sclerosis (HP:0007354)2.21440583
52Abnormal gallbladder physiology (HP:0012438)2.18078382
53Cholecystitis (HP:0001082)2.18078382
54Ankyloglossia (HP:0010296)2.16617749
55Abnormality of the duodenum (HP:0002246)2.16427644
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.15204960
57Myelodysplasia (HP:0002863)2.14915771
58Atresia of the external auditory canal (HP:0000413)2.13314548
59Squamous cell carcinoma (HP:0002860)2.11575146
60Selective tooth agenesis (HP:0001592)2.10067829
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09643982
62Orthostatic hypotension (HP:0001278)2.09624362
63Cafe-au-lait spot (HP:0000957)2.09614847
64Macroorchidism (HP:0000053)2.09228045
65Short humerus (HP:0005792)2.08264201
66Heterotopia (HP:0002282)2.07277669
67Breast hypoplasia (HP:0003187)2.05133572
68Absent frontal sinuses (HP:0002688)2.02950564
69Aplasia/hypoplasia of the humerus (HP:0006507)2.01935802
70Pseudobulbar signs (HP:0002200)2.01512053
71Thyroiditis (HP:0100646)2.00493247
72Prominent nose (HP:0000448)2.00267467
73Aqueductal stenosis (HP:0002410)1.99854391
74Hypochromic anemia (HP:0001931)1.99493945
75Trismus (HP:0000211)1.99245242
76Ulnar bowing (HP:0003031)1.99184748
77Short 4th metacarpal (HP:0010044)1.98892421
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98892421
79Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98667178
80Absent epiphyses (HP:0010577)1.98667178
81Sloping forehead (HP:0000340)1.98184937
82Abnormality of the preputium (HP:0100587)1.98028033
83Neoplasm of the oral cavity (HP:0100649)1.97794035
84Abnormality of oral frenula (HP:0000190)1.97600882
85Overriding aorta (HP:0002623)1.97557334
86Esophageal atresia (HP:0002032)1.97438924
87Missing ribs (HP:0000921)1.94901387
88Malignant gastrointestinal tract tumors (HP:0006749)1.93736593
89Gastrointestinal carcinoma (HP:0002672)1.93736593
90Abnormal number of incisors (HP:0011064)1.92277336
91Abnormality of the carotid arteries (HP:0005344)1.90634260
92Poikiloderma (HP:0001029)1.90484889
93Pendular nystagmus (HP:0012043)1.89801005
94Choanal atresia (HP:0000453)1.89504056
95Duplication of thumb phalanx (HP:0009942)1.88331148
96Elfin facies (HP:0004428)1.88221210
97Absent radius (HP:0003974)1.87661068
98Small epiphyses (HP:0010585)1.87526774
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87334567
100Abnormality of reticulocytes (HP:0004312)1.86171661
101High pitched voice (HP:0001620)1.86017684
102Adenoma sebaceum (HP:0009720)1.83632861
103Angiofibromas (HP:0010615)1.83632861
104Abnormality of cochlea (HP:0000375)1.83544441
105Flared metaphyses (HP:0003015)1.83349947
106Abnormality of abdominal situs (HP:0011620)1.82758528
107Abdominal situs inversus (HP:0003363)1.82758528
108Oligodactyly (hands) (HP:0001180)1.82130368
109Intestinal atresia (HP:0011100)1.81721470
110Hyperacusis (HP:0010780)1.81496666
111Colon cancer (HP:0003003)1.80950959
112Broad palm (HP:0001169)1.80927010
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79168837
114Abnormality of the salivary glands (HP:0010286)1.78310448
115Intestinal fistula (HP:0100819)1.78173700
116Long palpebral fissure (HP:0000637)1.78036393
117Shawl scrotum (HP:0000049)1.77126961
118Disproportionate tall stature (HP:0001519)1.77005327
119Rectovaginal fistula (HP:0000143)1.76648591
120Rectal fistula (HP:0100590)1.76648591
121Trigonocephaly (HP:0000243)1.76638297
122Deep palmar crease (HP:0006191)1.76133749
123Truncal obesity (HP:0001956)1.75720573
124Spinal muscular atrophy (HP:0007269)1.75621350
125Proximal placement of thumb (HP:0009623)1.75098252
126Short 5th finger (HP:0009237)1.74877287
127Abnormality of glycolysis (HP:0004366)1.74777723
128Urethral obstruction (HP:0000796)1.74435107
129Obsessive-compulsive behavior (HP:0000722)1.74146069
130Pointed chin (HP:0000307)1.73058475
131Leiomyosarcoma (HP:0100243)1.72594023
132Uterine leiomyosarcoma (HP:0002891)1.72594023
133Difficulty running (HP:0009046)1.72584955
134Vertebral arch anomaly (HP:0008438)1.72489286
135Tracheoesophageal fistula (HP:0002575)1.71700392
136Aplasia involving forearm bones (HP:0009822)1.71640129
137Absent forearm bone (HP:0003953)1.71640129
138Sandal gap (HP:0001852)1.69905489
139Hemivertebrae (HP:0002937)1.69591094
140Deviation of the thumb (HP:0009603)1.69348183
141Supernumerary spleens (HP:0009799)1.68700095
142Facial hemangioma (HP:0000329)1.67929313
143Abnormality of the umbilical cord (HP:0010881)1.67763364
144Embryonal neoplasm (HP:0002898)1.66884869
145Fused cervical vertebrae (HP:0002949)1.66819381
146Abnormal foot bone ossification (HP:0010675)1.66525140
147Relative macrocephaly (HP:0004482)1.66203662
148Skull defect (HP:0001362)1.65098298
149Ectopic kidney (HP:0000086)1.64558858
150Abnormality of the labia minora (HP:0012880)1.64523305
151Long eyelashes (HP:0000527)1.64510528
152Resting tremor (HP:0002322)1.64393036
153Horseshoe kidney (HP:0000085)1.62742525
154Glossoptosis (HP:0000162)1.62151537
155Short thumb (HP:0009778)1.60298565
156Spinal cord lesions (HP:0100561)1.59683524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.30007989
2CDC74.12161947
3TLK13.87226028
4SMG13.46214414
5MAP3K103.29226206
6GRK63.22292291
7NEK22.74002282
8TTK2.50852426
9EEF2K2.49804526
10PBK2.31613820
11STK102.30707721
12ZAK2.08835825
13CSF1R2.01340289
14VRK21.90838565
15EIF2AK11.90171007
16ERN11.83912281
17CHEK21.79006688
18GRK51.73430565
19WEE11.70510134
20RPS6KB21.63644553
21STK41.62951302
22TAF11.62559095
23SRPK11.56931022
24PLK11.55435557
25TYRO31.52852805
26PKN21.50591075
27BUB11.48909929
28AURKB1.47102262
29CDK71.44408987
30PLK41.44031985
31NME21.43949525
32MST1R1.36752153
33CDK41.33132853
34TGFBR21.32137657
35CHEK11.31214502
36PRPF4B1.27923341
37ATR1.25685342
38VRK11.24144175
39PAK41.22750805
40SCYL21.20384637
41IRAK31.19371440
42CDK81.18403536
43MAP3K81.16407566
44MATK1.15407808
45TRIB31.14511776
46CCNB11.11275502
47DYRK31.10558318
48PASK1.05098834
49GRK11.04759991
50NEK11.04517749
51MAPK71.04306583
52CDK61.02531016
53HIPK21.01914059
54FGFR31.00263842
55WNK10.99523005
56BRAF0.99227772
57PIM10.96781147
58ATM0.93844521
59CDK90.91907296
60FGFR40.91299155
61AKT20.90369799
62CDK20.87084535
63MTOR0.86421916
64ALK0.84867732
65DYRK1B0.84550227
66LATS20.84383563
67BRD40.81594454
68RPS6KA50.81377240
69ICK0.79716507
70MELK0.78893585
71PDGFRA0.75985949
72KSR20.75485166
73AURKA0.73994466
74MET0.73042933
75TTN0.72606573
76ADRBK20.69951607
77EPHA20.69040198
78ACVR1B0.68232937
79CAMK40.66280132
80CDK10.66231599
81MAPK110.66149235
82LRRK20.65998451
83STK30.58922817
84PLK30.56138448
85CDK11A0.55273378
86ERBB40.55160707
87CDK150.54859341
88PTK60.53577422
89CDK180.52367597
90TSSK60.51456008
91RPS6KA40.51016155
92TGFBR10.49637788
93BRSK20.49273652
94LATS10.47932414
95MARK20.45957743
96CAMK1D0.44860497
97CAMK1G0.44609543
98SIK20.43071610
99EIF2AK30.42836341
100RAF10.42783678
101CSNK1D0.42709897
102CDK140.42399315
103RIPK10.42111562
104BRSK10.41134744
105MAP3K90.40994414
106MOS0.40602225
107MAP3K70.40407587
108MAPK140.39903699
109CSK0.39175455
110FLT30.38579431
111MKNK10.37381393
112BMX0.37026324
113PTK20.36179828
114FGFR20.35618276
115PNCK0.35166145
116PAK10.34867977
117KSR10.34107462
118ITK0.32369325
119FGFR10.31888946
120ADRBK10.31665372
121TESK20.31336946
122AKT10.31159207
123PRKDC0.31088250
124MAP4K10.30050144
125MKNK20.29753867
126CLK10.29608130
127CSNK1E0.29202808
128CSNK2A20.29187063
129GSK3B0.27671602
130NEK90.27537917
131PRKAA10.26734248
132MAPK10.26410425
133YES10.26124280
134EIF2AK20.26067477
135SIK10.25173689
136PAK20.25094445
137TAOK20.23624356

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.93891826
2DNA replication_Homo sapiens_hsa030303.87945103
3Mismatch repair_Homo sapiens_hsa034303.17204392
4Cell cycle_Homo sapiens_hsa041102.86528488
5Alcoholism_Homo sapiens_hsa050342.80238797
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74560529
7Fanconi anemia pathway_Homo sapiens_hsa034602.35321230
8RNA transport_Homo sapiens_hsa030132.35198510
9Base excision repair_Homo sapiens_hsa034102.30098758
10Non-homologous end-joining_Homo sapiens_hsa034502.23135908
11Spliceosome_Homo sapiens_hsa030402.19289101
12Viral carcinogenesis_Homo sapiens_hsa052032.17596201
13mRNA surveillance pathway_Homo sapiens_hsa030152.13362401
14One carbon pool by folate_Homo sapiens_hsa006702.10496767
15Homologous recombination_Homo sapiens_hsa034402.03844845
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.84063554
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69766759
18Vitamin B6 metabolism_Homo sapiens_hsa007501.64203708
19Nucleotide excision repair_Homo sapiens_hsa034201.64028588
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62638095
21MicroRNAs in cancer_Homo sapiens_hsa052061.60827647
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60446508
23mTOR signaling pathway_Homo sapiens_hsa041501.56683749
24p53 signaling pathway_Homo sapiens_hsa041151.42144898
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40384669
26Carbon metabolism_Homo sapiens_hsa012001.28218080
27RNA degradation_Homo sapiens_hsa030181.23162786
28Fructose and mannose metabolism_Homo sapiens_hsa000511.22787590
29Small cell lung cancer_Homo sapiens_hsa052221.21569721
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19014858
31Non-small cell lung cancer_Homo sapiens_hsa052231.15798775
32Chronic myeloid leukemia_Homo sapiens_hsa052201.13308506
33HTLV-I infection_Homo sapiens_hsa051661.12770054
34Lysine degradation_Homo sapiens_hsa003101.10179335
35Proteasome_Homo sapiens_hsa030501.06398167
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05706933
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05538495
38Thyroid cancer_Homo sapiens_hsa052161.05060553
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03632202
40Colorectal cancer_Homo sapiens_hsa052101.03519844
41Ribosome_Homo sapiens_hsa030101.03066734
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.02191553
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.01997093
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95053824
45Herpes simplex infection_Homo sapiens_hsa051680.92773138
46B cell receptor signaling pathway_Homo sapiens_hsa046620.92175476
47Oocyte meiosis_Homo sapiens_hsa041140.91268657
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91066978
49Primary immunodeficiency_Homo sapiens_hsa053400.90705220
50RNA polymerase_Homo sapiens_hsa030200.88694813
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86678793
52Notch signaling pathway_Homo sapiens_hsa043300.86611964
53Basal cell carcinoma_Homo sapiens_hsa052170.85008772
54Pancreatic cancer_Homo sapiens_hsa052120.85003041
55N-Glycan biosynthesis_Homo sapiens_hsa005100.79934528
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.77988228
57Antigen processing and presentation_Homo sapiens_hsa046120.77260522
58Pyruvate metabolism_Homo sapiens_hsa006200.75452753
59Adherens junction_Homo sapiens_hsa045200.74908893
60Acute myeloid leukemia_Homo sapiens_hsa052210.74101816
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73996611
62Pathways in cancer_Homo sapiens_hsa052000.73889180
63Proteoglycans in cancer_Homo sapiens_hsa052050.73611255
64Hippo signaling pathway_Homo sapiens_hsa043900.70684629
65Apoptosis_Homo sapiens_hsa042100.69742366
66Bladder cancer_Homo sapiens_hsa052190.69168703
67Endometrial cancer_Homo sapiens_hsa052130.68804752
68Inositol phosphate metabolism_Homo sapiens_hsa005620.67960941
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.66396883
70Pyrimidine metabolism_Homo sapiens_hsa002400.66286015
71Purine metabolism_Homo sapiens_hsa002300.65558554
72Galactose metabolism_Homo sapiens_hsa000520.65315590
73Epstein-Barr virus infection_Homo sapiens_hsa051690.64517217
74Selenocompound metabolism_Homo sapiens_hsa004500.63019088
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.61734151
76Renal cell carcinoma_Homo sapiens_hsa052110.60099570
77Prostate cancer_Homo sapiens_hsa052150.58075388
78Pentose phosphate pathway_Homo sapiens_hsa000300.57518298
79Glioma_Homo sapiens_hsa052140.56919475
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56836926
81T cell receptor signaling pathway_Homo sapiens_hsa046600.55694687
82AMPK signaling pathway_Homo sapiens_hsa041520.54753577
83Hepatitis B_Homo sapiens_hsa051610.54201123
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53862542
85Basal transcription factors_Homo sapiens_hsa030220.52254253
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50774365
87ErbB signaling pathway_Homo sapiens_hsa040120.50302090
88VEGF signaling pathway_Homo sapiens_hsa043700.49684246
89Hedgehog signaling pathway_Homo sapiens_hsa043400.47907895
90Tight junction_Homo sapiens_hsa045300.47543435
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.47102080
92TGF-beta signaling pathway_Homo sapiens_hsa043500.46404970
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.46227320
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46205436
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45296635
96Focal adhesion_Homo sapiens_hsa045100.44525540
97HIF-1 signaling pathway_Homo sapiens_hsa040660.43387899
98Insulin signaling pathway_Homo sapiens_hsa049100.43317324
99Folate biosynthesis_Homo sapiens_hsa007900.42678500
100Viral myocarditis_Homo sapiens_hsa054160.42562497
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41765050
102Shigellosis_Homo sapiens_hsa051310.39881993
103Wnt signaling pathway_Homo sapiens_hsa043100.39488154
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39014532
105FoxO signaling pathway_Homo sapiens_hsa040680.38385524
106Sulfur relay system_Homo sapiens_hsa041220.38296167
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36831784
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36561473
109Biosynthesis of amino acids_Homo sapiens_hsa012300.35680458
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34631490
111Influenza A_Homo sapiens_hsa051640.34375771
112Measles_Homo sapiens_hsa051620.33496334
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32850172
114Choline metabolism in cancer_Homo sapiens_hsa052310.32786558
115Rap1 signaling pathway_Homo sapiens_hsa040150.32761445
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31750276
117Steroid biosynthesis_Homo sapiens_hsa001000.31732128
118Toxoplasmosis_Homo sapiens_hsa051450.31666494
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31598582
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30281866
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30248043
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30046689
123Insulin resistance_Homo sapiens_hsa049310.29527973
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28177944
125Hematopoietic cell lineage_Homo sapiens_hsa046400.27206856
126Melanoma_Homo sapiens_hsa052180.26842078

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