NCAPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.12316474
2protein localization to chromosome, centromeric region (GO:0071459)5.37171471
3kinetochore organization (GO:0051383)5.29913102
4mitotic metaphase plate congression (GO:0007080)5.16198751
5DNA unwinding involved in DNA replication (GO:0006268)5.15298211
6attachment of spindle microtubules to kinetochore (GO:0008608)5.08068269
7* mitotic chromosome condensation (GO:0007076)4.96313321
8mitotic sister chromatid segregation (GO:0000070)4.94243214
9CENP-A containing nucleosome assembly (GO:0034080)4.90973225
10chromatin remodeling at centromere (GO:0031055)4.90531516
11sister chromatid segregation (GO:0000819)4.85659760
12nuclear pore complex assembly (GO:0051292)4.78082688
13nuclear pore organization (GO:0006999)4.76237302
14metaphase plate congression (GO:0051310)4.71014584
15DNA strand elongation involved in DNA replication (GO:0006271)4.65626804
16DNA replication initiation (GO:0006270)4.59671079
17DNA ligation (GO:0006266)4.57416942
18meiotic chromosome segregation (GO:0045132)4.51187644
19DNA replication-independent nucleosome assembly (GO:0006336)4.44728695
20DNA replication-independent nucleosome organization (GO:0034724)4.44728695
21DNA strand elongation (GO:0022616)4.42308103
22DNA replication-dependent nucleosome assembly (GO:0006335)4.41594990
23DNA replication-dependent nucleosome organization (GO:0034723)4.41594990
24regulation of spindle organization (GO:0090224)4.39743954
25establishment of integrated proviral latency (GO:0075713)4.36384403
26establishment of chromosome localization (GO:0051303)4.35174074
27kinetochore assembly (GO:0051382)4.34399071
28telomere maintenance via semi-conservative replication (GO:0032201)4.34166099
29mitotic nuclear envelope disassembly (GO:0007077)4.33719325
30DNA replication checkpoint (GO:0000076)4.33222394
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.31438792
32histone exchange (GO:0043486)4.25343829
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.24305516
34mitotic recombination (GO:0006312)4.24227274
35telomere maintenance via recombination (GO:0000722)4.09328931
36nuclear envelope disassembly (GO:0051081)4.04176736
37membrane disassembly (GO:0030397)4.04176736
38mitotic sister chromatid cohesion (GO:0007064)4.00498326
39protein localization to chromosome (GO:0034502)3.96826135
40regulation of mitotic spindle organization (GO:0060236)3.95747061
41positive regulation of chromosome segregation (GO:0051984)3.95683101
42spindle checkpoint (GO:0031577)3.91222538
43regulation of chromosome segregation (GO:0051983)3.82633841
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.80391865
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.80391865
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.80391865
47chromosome segregation (GO:0007059)3.78821747
48regulation of sister chromatid cohesion (GO:0007063)3.74205466
49chromatin assembly or disassembly (GO:0006333)3.74193306
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.68945427
51telomere maintenance via telomere lengthening (GO:0010833)3.68250135
52spindle assembly checkpoint (GO:0071173)3.67847206
53pore complex assembly (GO:0046931)3.66340348
54DNA geometric change (GO:0032392)3.65185197
55negative regulation of chromosome segregation (GO:0051985)3.64908167
56DNA duplex unwinding (GO:0032508)3.64827690
57regulation of centrosome cycle (GO:0046605)3.64521924
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.63899700
59regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.63781497
60double-strand break repair via nonhomologous end joining (GO:0006303)3.62645981
61non-recombinational repair (GO:0000726)3.62645981
62negative regulation of sister chromatid segregation (GO:0033046)3.62128558
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.62128558
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.62128558
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.62128558
66regulation of centriole replication (GO:0046599)3.59746532
67DNA topological change (GO:0006265)3.56724657
68mitotic G2/M transition checkpoint (GO:0044818)3.56276266
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55646322
70mitotic spindle checkpoint (GO:0071174)3.54137331
71mitotic spindle assembly checkpoint (GO:0007094)3.53249325
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.51738815
73regulation of mitotic sister chromatid separation (GO:0010965)3.50359531
74regulation of mitotic sister chromatid segregation (GO:0033047)3.50359531
75regulation of sister chromatid segregation (GO:0033045)3.50359531
76regulation of histone H3-K9 methylation (GO:0051570)3.41993207
77ATP-dependent chromatin remodeling (GO:0043044)3.40038884
78* chromosome condensation (GO:0030261)3.39597842
79folic acid-containing compound biosynthetic process (GO:0009396)3.35833653
80protein K6-linked ubiquitination (GO:0085020)3.35332798
81IMP biosynthetic process (GO:0006188)3.33879606
82heterochromatin organization (GO:0070828)3.33521839
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.32387915
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32387915
85negative regulation of mitosis (GO:0045839)3.30070170
86* DNA conformation change (GO:0071103)3.29328407
87establishment of viral latency (GO:0019043)3.24820835
88DNA synthesis involved in DNA repair (GO:0000731)3.24156049
89microtubule depolymerization (GO:0007019)3.23862362
90nucleobase biosynthetic process (GO:0046112)3.21295643
91mismatch repair (GO:0006298)3.17198010
92mitotic spindle organization (GO:0007052)3.15105118
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.14927426
94* DNA packaging (GO:0006323)3.13321945
95* chromosome organization (GO:0051276)3.11263175
96telomere maintenance (GO:0000723)3.09872381
97nuclear envelope organization (GO:0006998)3.09859533
98DNA strand renaturation (GO:0000733)3.09283159
99IMP metabolic process (GO:0046040)3.08421906
100* mitotic cell cycle (GO:0000278)3.07678246
101telomere organization (GO:0032200)3.07513733
102formation of translation preinitiation complex (GO:0001731)3.07168048
103protein complex localization (GO:0031503)3.07153633
104regulation of DNA endoreduplication (GO:0032875)3.06652549
105synapsis (GO:0007129)3.06321577
106translesion synthesis (GO:0019985)3.03706426
107maturation of SSU-rRNA (GO:0030490)3.03352711
108purine nucleobase biosynthetic process (GO:0009113)3.03254467
109spindle assembly involved in mitosis (GO:0090307)3.02664660
110regulation of centrosome duplication (GO:0010824)3.01421791
111chromatin assembly (GO:0031497)2.99153114
112negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.99004642
113sister chromatid cohesion (GO:0007062)2.98944867
114DNA double-strand break processing (GO:0000729)2.98659292
115regulation of helicase activity (GO:0051095)2.96622368
116postreplication repair (GO:0006301)2.95844325
117negative regulation of histone methylation (GO:0031061)2.95564375
118intra-S DNA damage checkpoint (GO:0031573)2.94727671
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93933460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.60493645
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.92714557
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.18954124
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71814610
5AR_21909140_ChIP-Seq_LNCAP_Human2.92842803
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90840550
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68902143
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65938851
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65820179
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55020991
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.48415234
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44850668
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.38150772
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.33037909
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32131759
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25682712
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22279555
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18133435
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07320147
20XRN2_22483619_ChIP-Seq_HELA_Human2.04861941
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.02802386
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.01346025
23E2F7_22180533_ChIP-Seq_HELA_Human11.1751119
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96397044
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90346076
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86296478
27* VDR_23849224_ChIP-Seq_CD4+_Human1.86287887
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82481435
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71782990
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.71510674
31DCP1A_22483619_ChIP-Seq_HELA_Human1.67180196
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66542989
33TTF2_22483619_ChIP-Seq_HELA_Human1.66536144
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65387536
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65246821
36ELK1_19687146_ChIP-ChIP_HELA_Human1.64402578
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56666966
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.56276933
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54897543
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52435409
41CIITA_25753668_ChIP-Seq_RAJI_Human1.48040960
42* GABP_19822575_ChIP-Seq_HepG2_Human1.43005827
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39733212
44MYC_22102868_ChIP-Seq_BL_Human1.39265226
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38908738
46KDM5A_27292631_Chip-Seq_BREAST_Human1.38483786
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37534835
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.36929831
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36615678
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34538664
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33295297
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32429574
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30400254
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26482274
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26455367
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25366214
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25045281
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24686022
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24430798
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22689144
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20660370
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19678439
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15954291
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12917140
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11126533
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07186444
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05289589
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02788272
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02714769
70TFEB_21752829_ChIP-Seq_HELA_Human1.00356982
71* MYC_18940864_ChIP-ChIP_HL60_Human0.99527625
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95820967
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95800826
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95368847
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95040632
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94192693
77YY1_21170310_ChIP-Seq_MESCs_Mouse0.92795938
78NANOG_21062744_ChIP-ChIP_HESCs_Human0.92708608
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91987447
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90550733
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90413940
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90396235
83* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87367545
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85044149
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84483737
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83537496
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80174594
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.80043485
89EWS_26573619_Chip-Seq_HEK293_Human0.80033984
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79575393
91CHD1_26751641_Chip-Seq_LNCaP_Human0.79484788
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77908080
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77162724
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76208140
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75898129
96VDR_21846776_ChIP-Seq_THP-1_Human0.75610089
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74992006
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74447573
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73439986
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71414032
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.70146872
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70047928
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.68806219
104SPI1_23547873_ChIP-Seq_NB4_Human0.68717636
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67723436
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.66787000
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66723619
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65181005
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.65170059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.31205492
2MP0003693_abnormal_embryo_hatching5.20030624
3MP0003111_abnormal_nucleus_morphology4.78070229
4MP0008057_abnormal_DNA_replication4.38040228
5MP0003077_abnormal_cell_cycle4.27261237
6MP0004957_abnormal_blastocyst_morpholog4.20090614
7MP0008058_abnormal_DNA_repair3.17957007
8MP0008877_abnormal_DNA_methylation2.90591808
9MP0008007_abnormal_cellular_replicative2.73593202
10MP0008932_abnormal_embryonic_tissue2.61459704
11MP0003123_paternal_imprinting2.57386796
12MP0001730_embryonic_growth_arrest2.38836962
13MP0010307_abnormal_tumor_latency2.38737778
14MP0000350_abnormal_cell_proliferation2.31206916
15MP0010352_gastrointestinal_tract_polyps2.25911800
16MP0002396_abnormal_hematopoietic_system2.00203483
17MP0003121_genomic_imprinting1.92822284
18MP0005380_embryogenesis_phenotype1.85076308
19MP0001672_abnormal_embryogenesis/_devel1.85076308
20MP0003786_premature_aging1.84328611
21MP0001697_abnormal_embryo_size1.81517144
22MP0002877_abnormal_melanocyte_morpholog1.68938418
23MP0002085_abnormal_embryonic_tissue1.67272074
24MP0005076_abnormal_cell_differentiation1.64878548
25MP0006292_abnormal_olfactory_placode1.64294008
26MP0002084_abnormal_developmental_patter1.61753073
27MP0003984_embryonic_growth_retardation1.61024589
28MP0002088_abnormal_embryonic_growth/wei1.57763734
29MP0002080_prenatal_lethality1.56355640
30MP0003718_maternal_effect1.55836637
31MP0000490_abnormal_crypts_of1.53939460
32MP0004197_abnormal_fetal_growth/weight/1.53913900
33MP0004808_abnormal_hematopoietic_stem1.49785049
34MP0002086_abnormal_extraembryonic_tissu1.48590546
35MP0002210_abnormal_sex_determination1.48376776
36MP0003890_abnormal_embryonic-extraembry1.41881628
37MP0000313_abnormal_cell_death1.41561807
38MP0002019_abnormal_tumor_incidence1.41235145
39MP0010030_abnormal_orbit_morphology1.29312425
40MP0001929_abnormal_gametogenesis1.27949738
41MP0003567_abnormal_fetal_cardiomyocyte1.27162279
42MP0001145_abnormal_male_reproductive1.25411317
43MP0003705_abnormal_hypodermis_morpholog1.22173862
44MP0000653_abnormal_sex_gland1.14800143
45MP0003315_abnormal_perineum_morphology1.14282138
46MP0003937_abnormal_limbs/digits/tail_de1.12747128
47MP0001293_anophthalmia1.12502107
48MP0003787_abnormal_imprinting1.10267517
49MP0006054_spinal_hemorrhage1.08529850
50MP0009053_abnormal_anal_canal1.03360432
51MP0000703_abnormal_thymus_morphology1.03181508
52MP0001119_abnormal_female_reproductive1.00532498
53MP0000537_abnormal_urethra_morphology0.99935841
54MP0002009_preneoplasia0.96043030
55MP0002233_abnormal_nose_morphology0.95135530
56MP0000358_abnormal_cell_content/0.94781985
57MP0006035_abnormal_mitochondrial_morpho0.91520824
58MP0001346_abnormal_lacrimal_gland0.90448752
59MP0003385_abnormal_body_wall0.90311199
60MP0009672_abnormal_birth_weight0.89545005
61MP0005397_hematopoietic_system_phenotyp0.89468993
62MP0001545_abnormal_hematopoietic_system0.89468993
63MP0003806_abnormal_nucleotide_metabolis0.89346510
64MP0001915_intracranial_hemorrhage0.86159031
65MP0002398_abnormal_bone_marrow0.85685255
66MP0003136_yellow_coat_color0.84541899
67MP0003763_abnormal_thymus_physiology0.84267152
68MP0001529_abnormal_vocalization0.83365127
69MP0002111_abnormal_tail_morphology0.83338166
70MP0009333_abnormal_splenocyte_physiolog0.82888865
71MP0004233_abnormal_muscle_weight0.81066196
72MP0009703_decreased_birth_body0.80619811
73MP0004185_abnormal_adipocyte_glucose0.79834000
74MP0002722_abnormal_immune_system0.79718305
75MP0010234_abnormal_vibrissa_follicle0.77694804
76MP0005621_abnormal_cell_physiology0.76741815
77MP0005023_abnormal_wound_healing0.76727419
78MP0003941_abnormal_skin_development0.76601743
79MP0005384_cellular_phenotype0.76488983
80MP0003119_abnormal_digestive_system0.75970664
81MP0003221_abnormal_cardiomyocyte_apopto0.75751532
82MP0000689_abnormal_spleen_morphology0.73713288
83MP0002092_abnormal_eye_morphology0.73079385
84MP0004264_abnormal_extraembryonic_tissu0.72639174
85MP0003566_abnormal_cell_adhesion0.72505673
86MP0003950_abnormal_plasma_membrane0.72030109
87MP0001286_abnormal_eye_development0.71655724
88MP0003943_abnormal_hepatobiliary_system0.70459269
89MP0005389_reproductive_system_phenotype0.70389409
90MP0005623_abnormal_meninges_morphology0.69845972
91MP0009278_abnormal_bone_marrow0.68191964
92MP0000432_abnormal_head_morphology0.68009741
93MP0002234_abnormal_pharynx_morphology0.67709783
94MP0001661_extended_life_span0.67422154
95MP0005501_abnormal_skin_physiology0.67123793
96MP0000428_abnormal_craniofacial_morphol0.65775682
97MP0003699_abnormal_female_reproductive0.65118111
98MP0003115_abnormal_respiratory_system0.64841620
99MP0002697_abnormal_eye_size0.64226892
100MP0003698_abnormal_male_reproductive0.64116074
101MP0001299_abnormal_eye_distance/0.63918548
102MP0000858_altered_metastatic_potential0.63143902
103MP0002160_abnormal_reproductive_system0.62694861
104MP0000049_abnormal_middle_ear0.62086612
105MP0000733_abnormal_muscle_development0.62071097
106MP0005408_hypopigmentation0.61937777
107MP0003935_abnormal_craniofacial_develop0.61651260
108MP0000647_abnormal_sebaceous_gland0.61339171
109MP0002429_abnormal_blood_cell0.60767954
110MP0002161_abnormal_fertility/fecundity0.60430063
111MP0005391_vision/eye_phenotype0.60067077
112MP0008789_abnormal_olfactory_epithelium0.59425190
113MP0002925_abnormal_cardiovascular_devel0.59013858
114MP0002114_abnormal_axial_skeleton0.58967309
115MP0000477_abnormal_intestine_morphology0.58885668
116MP0000383_abnormal_hair_follicle0.58741043
117MP0000762_abnormal_tongue_morphology0.58605729
118MP0000372_irregular_coat_pigmentation0.57665899
119MP0002081_perinatal_lethality0.56801175
120MP0002932_abnormal_joint_morphology0.56765126
121MP0000569_abnormal_digit_pigmentation0.56739599
122MP0001188_hyperpigmentation0.56127045
123MP0001919_abnormal_reproductive_system0.55064133
124MP0009697_abnormal_copulation0.54449123
125MP0001849_ear_inflammation0.54164947
126MP0002095_abnormal_skin_pigmentation0.53132697
127MP0003755_abnormal_palate_morphology0.52960598
128MP0003448_altered_tumor_morphology0.52563435
129MP0003861_abnormal_nervous_system0.52502154
130MP0002938_white_spotting0.51396012
131MP0002102_abnormal_ear_morphology0.51294497
132MP0002075_abnormal_coat/hair_pigmentati0.50747621

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.20883772
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.81085439
3Birth length less than 3rd percentile (HP:0003561)4.06268042
4Abnormality of chromosome stability (HP:0003220)3.98506162
5Cortical dysplasia (HP:0002539)3.79692229
6Reticulocytopenia (HP:0001896)3.64300914
7Meckel diverticulum (HP:0002245)3.45197693
8Abnormality of the preputium (HP:0100587)3.34057140
9Colon cancer (HP:0003003)3.33892839
10Medulloblastoma (HP:0002885)3.29402417
11Selective tooth agenesis (HP:0001592)3.29107645
12Small intestinal stenosis (HP:0012848)3.28268778
13Duodenal stenosis (HP:0100867)3.28268778
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.28081296
15Abnormality of the ileum (HP:0001549)3.26796217
16Patellar aplasia (HP:0006443)3.23997107
17Volvulus (HP:0002580)3.22749021
18Increased nuchal translucency (HP:0010880)3.14956348
19Ependymoma (HP:0002888)3.11502047
20Abnormal lung lobation (HP:0002101)3.09081773
21Impulsivity (HP:0100710)3.07202168
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05158070
23Breast hypoplasia (HP:0003187)3.05075831
24Ectopic kidney (HP:0000086)3.03922149
25Aplasia/Hypoplasia of the patella (HP:0006498)2.97342075
26Abnormality of the labia minora (HP:0012880)2.97227115
27Nephroblastoma (Wilms tumor) (HP:0002667)2.95142211
28Rhabdomyosarcoma (HP:0002859)2.94373447
29Myelodysplasia (HP:0002863)2.94278119
30Absent radius (HP:0003974)2.82700416
31Embryonal renal neoplasm (HP:0011794)2.76604528
32Sloping forehead (HP:0000340)2.74173992
33Agnosia (HP:0010524)2.70719225
34Abnormality of the duodenum (HP:0002246)2.69720502
35Duplicated collecting system (HP:0000081)2.66565974
36Oral leukoplakia (HP:0002745)2.64748914
37Aplasia involving forearm bones (HP:0009822)2.62050534
38Absent forearm bone (HP:0003953)2.62050534
39Carpal bone hypoplasia (HP:0001498)2.58532923
4011 pairs of ribs (HP:0000878)2.56446159
41Supernumerary spleens (HP:0009799)2.52862679
42Absent thumb (HP:0009777)2.48948456
43Proximal placement of thumb (HP:0009623)2.47136431
44Abnormality of the carotid arteries (HP:0005344)2.43811738
45Deviation of the thumb (HP:0009603)2.43742198
46Short 4th metacarpal (HP:0010044)2.43592296
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43592296
48Cafe-au-lait spot (HP:0000957)2.42289515
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.36917124
50Facial hemangioma (HP:0000329)2.35456032
51Abnormality of the renal collecting system (HP:0004742)2.33414906
52Neoplasm of the pancreas (HP:0002894)2.32911001
53Abnormal number of incisors (HP:0011064)2.31321996
54Bone marrow hypocellularity (HP:0005528)2.31271809
55Basal cell carcinoma (HP:0002671)2.27741321
56Biliary tract neoplasm (HP:0100574)2.24069616
57Embryonal neoplasm (HP:0002898)2.23240936
58High pitched voice (HP:0001620)2.23037722
59Horseshoe kidney (HP:0000085)2.21781353
60Astrocytoma (HP:0009592)2.20370011
61Abnormality of the astrocytes (HP:0100707)2.20370011
62Neoplasm of the colon (HP:0100273)2.19960204
63Short thumb (HP:0009778)2.18386407
64Neoplasm of striated muscle (HP:0009728)2.18057618
65Choanal atresia (HP:0000453)2.16197033
66Atresia of the external auditory canal (HP:0000413)2.15851169
67Abnormality of the anterior horn cell (HP:0006802)2.13548840
68Degeneration of anterior horn cells (HP:0002398)2.13548840
69Prominent nose (HP:0000448)2.10880160
70Duplication of thumb phalanx (HP:0009942)2.10780190
71Tracheoesophageal fistula (HP:0002575)2.09291267
72Missing ribs (HP:0000921)2.09086207
73Neoplasm of the oral cavity (HP:0100649)2.08863238
74Squamous cell carcinoma (HP:0002860)2.06965111
75Abnormality of cells of the erythroid lineage (HP:0012130)2.06612241
76Abnormality of glycolysis (HP:0004366)2.06528174
77Abnormality of DNA repair (HP:0003254)2.06206761
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05324172
79Ovarian neoplasm (HP:0100615)2.04649522
80Hypoplastic pelvis (HP:0008839)2.03857524
81Clubbing of toes (HP:0100760)2.02143293
82Premature graying of hair (HP:0002216)2.01338871
83Glioma (HP:0009733)2.00452328
84Triphalangeal thumb (HP:0001199)2.00423070
85Aplastic anemia (HP:0001915)1.98942477
86Abnormality of cochlea (HP:0000375)1.98771498
87Abnormality of chromosome segregation (HP:0002916)1.98128846
88Abnormality of the fetal cardiovascular system (HP:0010948)1.97107004
89Abnormal umbilical cord blood vessels (HP:0011403)1.97107004
90Single umbilical artery (HP:0001195)1.97107004
91Microvesicular hepatic steatosis (HP:0001414)1.94618065
92Abnormal number of erythroid precursors (HP:0012131)1.93247010
93Rough bone trabeculation (HP:0100670)1.92268936
94Gastrointestinal carcinoma (HP:0002672)1.91886592
95Malignant gastrointestinal tract tumors (HP:0006749)1.91886592
96Sandal gap (HP:0001852)1.88334554
97High anterior hairline (HP:0009890)1.87996588
98Multiple enchondromatosis (HP:0005701)1.87884354
99Cellular immunodeficiency (HP:0005374)1.82425170
100Overlapping toe (HP:0001845)1.82311022
101Increased serum pyruvate (HP:0003542)1.80705832
102Pallor (HP:0000980)1.80394478
103Progressive external ophthalmoplegia (HP:0000590)1.80024179
104Abnormality of abdominal situs (HP:0011620)1.79361412
105Abdominal situs inversus (HP:0003363)1.79361412
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78697055
107Abnormality of the umbilical cord (HP:0010881)1.77780753
108Deep philtrum (HP:0002002)1.77758217
109Microglossia (HP:0000171)1.77053785
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76466914
111Abnormality of the calcaneus (HP:0008364)1.75310457
112Lymphoma (HP:0002665)1.73955385
113Arteriovenous malformation (HP:0100026)1.73112963
114Abnormal auditory evoked potentials (HP:0006958)1.72536360
115Cutaneous melanoma (HP:0012056)1.72448004
116Amaurosis fugax (HP:0100576)1.69027432
117Skull defect (HP:0001362)1.67509897
118Oligodactyly (HP:0012165)1.67086466
119Irregular epiphyses (HP:0010582)1.67067272
120Long eyelashes (HP:0000527)1.66750640
121Facial cleft (HP:0002006)1.63853783
122Leiomyosarcoma (HP:0100243)1.62623178
123Uterine leiomyosarcoma (HP:0002891)1.62623178
124Short middle phalanx of the 5th finger (HP:0004220)1.59736024
125Long clavicles (HP:0000890)1.55776649
126Absent epiphyses (HP:0010577)1.53524834
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53524834
128Shoulder girdle muscle weakness (HP:0003547)1.51293195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.30983217
2BUB14.18665662
3WEE14.06183590
4NEK23.58014149
5TTK3.36420290
6NEK12.78391066
7EIF2AK12.64340967
8BRSK22.40230183
9SRPK12.37648256
10PLK12.37131546
11PLK42.30717911
12CDK122.18536824
13AURKB2.09642133
14TLK12.03620271
15ACVR1B1.96816931
16ATR1.94933928
17CHEK21.86808675
18PLK31.85083837
19PASK1.84356316
20STK101.79016281
21MKNK11.75641256
22TAF11.66166863
23CCNB11.65446483
24STK41.61934164
25EEF2K1.60687921
26MAP3K81.57403871
27BRSK11.55039064
28CDK71.54003089
29VRK21.50030981
30VRK11.49318580
31CHEK11.47351844
32CDK41.43960918
33RPS6KB21.41264428
34RPS6KA41.41142721
35MELK1.38882843
36TSSK61.33359606
37AURKA1.27826281
38EIF2AK31.26142371
39DYRK31.25602918
40ATM1.21473001
41MST41.21290997
42TRIM281.19603077
43MKNK21.13855986
44ZAK1.12240424
45TGFBR11.09209070
46CDK61.07413564
47STK31.07349589
48BRD41.07033701
49TESK21.06474491
50MAP3K101.05657325
51SMG11.04646228
52CDK20.96243901
53SCYL20.94608068
54LATS10.93423205
55PBK0.91045316
56MST1R0.83433155
57* CDK10.83250358
58PKN20.79523558
59PIM10.76831173
60PAK40.75601467
61ERBB40.75407002
62CLK10.73096903
63CDK80.71932522
64EIF2AK20.70378609
65ALK0.62672826
66NME20.58946474
67LRRK20.58288977
68RPS6KA50.55597412
69EPHA20.55594989
70CSNK2A20.55425092
71BRAF0.54002459
72CSNK2A10.53015152
73STK38L0.52539676
74CDK180.50081478
75CDK90.50064878
76MET0.49802493
77BCR0.49725158
78ERBB30.49531152
79FLT30.49349271
80PLK20.47971162
81PAK10.47567798
82CDK30.46129757
83PRKDC0.45925292
84PNCK0.45045218
85MARK30.43306815
86NEK90.42522177
87CDK140.41354971
88CSNK1D0.40528858
89MTOR0.40481381
90TNIK0.39790256
91NUAK10.38622113
92STK160.37962039
93PDK40.36827493
94PDK30.36827493
95MAP4K10.34738850
96NME10.34558011
97KSR10.34333406
98MAPK140.33734098
99TESK10.32792130
100PRKCI0.32198204
101PDK20.31276737
102CSNK1E0.29519148
103BMPR1B0.28132989
104AKT10.27875118
105AKT20.27478973
106RAF10.26480864
107ICK0.26107622
108YES10.24143535
109TTN0.23615863
110FGFR10.22233512
111GSK3B0.20559180
112UHMK10.20395771
113MAPK10.19853716
114FRK0.18156147
115LATS20.16921821
116RPS6KB10.16500038
117PAK20.16131782
118TRPM70.13829000
119TEC0.12685030
120CDK11A0.12465410
121MAPK110.12342684
122CDK150.12089484

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14849051
2Mismatch repair_Homo sapiens_hsa034304.64002394
3Homologous recombination_Homo sapiens_hsa034403.58622012
4Cell cycle_Homo sapiens_hsa041103.49598728
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37111381
6RNA transport_Homo sapiens_hsa030133.18440844
7Spliceosome_Homo sapiens_hsa030403.16438703
8Base excision repair_Homo sapiens_hsa034103.12479121
9Nucleotide excision repair_Homo sapiens_hsa034202.90792560
10Fanconi anemia pathway_Homo sapiens_hsa034602.90235008
11One carbon pool by folate_Homo sapiens_hsa006702.69625553
12Non-homologous end-joining_Homo sapiens_hsa034502.63096729
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34387289
14RNA polymerase_Homo sapiens_hsa030202.30013027
15Ribosome_Homo sapiens_hsa030102.24803932
16RNA degradation_Homo sapiens_hsa030182.11348582
17mRNA surveillance pathway_Homo sapiens_hsa030152.08016031
18Systemic lupus erythematosus_Homo sapiens_hsa053222.07389475
19Proteasome_Homo sapiens_hsa030502.06381798
20Pyrimidine metabolism_Homo sapiens_hsa002402.01204864
21Basal transcription factors_Homo sapiens_hsa030222.00036190
22p53 signaling pathway_Homo sapiens_hsa041151.90868983
23Oocyte meiosis_Homo sapiens_hsa041141.41823290
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37113175
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33773404
26Viral carcinogenesis_Homo sapiens_hsa052031.33053917
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32578887
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18758635
29Epstein-Barr virus infection_Homo sapiens_hsa051691.14639707
30Pyruvate metabolism_Homo sapiens_hsa006201.12569528
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08542787
32MicroRNAs in cancer_Homo sapiens_hsa052061.07572059
33Herpes simplex infection_Homo sapiens_hsa051681.06068579
34Purine metabolism_Homo sapiens_hsa002301.05076167
35Steroid biosynthesis_Homo sapiens_hsa001001.02285240
36Antigen processing and presentation_Homo sapiens_hsa046120.97074590
37HTLV-I infection_Homo sapiens_hsa051660.95942891
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91099778
39Small cell lung cancer_Homo sapiens_hsa052220.89221785
40Alcoholism_Homo sapiens_hsa050340.88691996
41Selenocompound metabolism_Homo sapiens_hsa004500.84976726
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74352651
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70085520
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69255668
45Propanoate metabolism_Homo sapiens_hsa006400.68754179
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66028878
47TGF-beta signaling pathway_Homo sapiens_hsa043500.65230284
48Thyroid cancer_Homo sapiens_hsa052160.63911656
49Pentose phosphate pathway_Homo sapiens_hsa000300.60816940
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59770070
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58957512
52Colorectal cancer_Homo sapiens_hsa052100.58160003
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.56808549
54Hippo signaling pathway_Homo sapiens_hsa043900.54647468
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54037637
56Biosynthesis of amino acids_Homo sapiens_hsa012300.53735573
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53624749
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.52535928
59Fatty acid elongation_Homo sapiens_hsa000620.51461271
60Primary immunodeficiency_Homo sapiens_hsa053400.51223892
61Huntingtons disease_Homo sapiens_hsa050160.50032247
62Basal cell carcinoma_Homo sapiens_hsa052170.49875162
63Hepatitis B_Homo sapiens_hsa051610.49010498
64Apoptosis_Homo sapiens_hsa042100.48272735
65Chronic myeloid leukemia_Homo sapiens_hsa052200.47674122
66Sulfur relay system_Homo sapiens_hsa041220.46176925
67Lysine degradation_Homo sapiens_hsa003100.45878201
68Legionellosis_Homo sapiens_hsa051340.45484525
69Vitamin B6 metabolism_Homo sapiens_hsa007500.43595554
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43306275
71Adherens junction_Homo sapiens_hsa045200.41810004
72Viral myocarditis_Homo sapiens_hsa054160.40017653
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39926737
74Bladder cancer_Homo sapiens_hsa052190.38798442
75Pancreatic cancer_Homo sapiens_hsa052120.38748467
76Notch signaling pathway_Homo sapiens_hsa043300.38436964
77Prostate cancer_Homo sapiens_hsa052150.38351065
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37381208
79Measles_Homo sapiens_hsa051620.36801649
80Pathways in cancer_Homo sapiens_hsa052000.36541997
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34772611
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.34686542
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.32941460
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32904678
85Non-small cell lung cancer_Homo sapiens_hsa052230.31996659
86Influenza A_Homo sapiens_hsa051640.31856385
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30299418
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30050159
89Shigellosis_Homo sapiens_hsa051310.29426371
90Parkinsons disease_Homo sapiens_hsa050120.29315844
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28581105
92mTOR signaling pathway_Homo sapiens_hsa041500.26945432
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26925428
94HIF-1 signaling pathway_Homo sapiens_hsa040660.26908410
95Hematopoietic cell lineage_Homo sapiens_hsa046400.25745091
96Glutathione metabolism_Homo sapiens_hsa004800.25715835
97Metabolic pathways_Homo sapiens_hsa011000.25710304
98Hedgehog signaling pathway_Homo sapiens_hsa043400.25541667
99FoxO signaling pathway_Homo sapiens_hsa040680.25018626
100N-Glycan biosynthesis_Homo sapiens_hsa005100.24863775
101Fatty acid metabolism_Homo sapiens_hsa012120.23492578
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22465298
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.22280782
104Folate biosynthesis_Homo sapiens_hsa007900.21851081
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20722794
106Proteoglycans in cancer_Homo sapiens_hsa052050.19640214
107Melanoma_Homo sapiens_hsa052180.18996731
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.18681858
109Protein export_Homo sapiens_hsa030600.16274621
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.16118463
111Tight junction_Homo sapiens_hsa045300.14092360
112Wnt signaling pathway_Homo sapiens_hsa043100.13951449
113Carbon metabolism_Homo sapiens_hsa012000.13878080
114Arginine and proline metabolism_Homo sapiens_hsa003300.13719879
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13450355
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12855489
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12737475
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12341392
119Glioma_Homo sapiens_hsa052140.11983328
120Renin-angiotensin system_Homo sapiens_hsa046140.11232893
121Endometrial cancer_Homo sapiens_hsa052130.10011105
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09184742
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07105047
124B cell receptor signaling pathway_Homo sapiens_hsa046620.06851612
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05768353

Most similar genes based on co-expression Upload to Enrichr

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