NCAPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.17014958
2DNA unwinding involved in DNA replication (GO:0006268)5.62438183
3protein localization to chromosome, centromeric region (GO:0071459)5.36761253
4mitotic sister chromatid segregation (GO:0000070)5.19379603
5sister chromatid segregation (GO:0000819)5.04815064
6DNA strand elongation involved in DNA replication (GO:0006271)5.01356837
7kinetochore organization (GO:0051383)4.96662336
8mitotic metaphase plate congression (GO:0007080)4.91100908
9attachment of spindle microtubules to kinetochore (GO:0008608)4.84109729
10* mitotic chromosome condensation (GO:0007076)4.76914522
11DNA strand elongation (GO:0022616)4.75670755
12telomere maintenance via semi-conservative replication (GO:0032201)4.68169838
13DNA replication initiation (GO:0006270)4.65627376
14establishment of integrated proviral latency (GO:0075713)4.52936467
15CENP-A containing nucleosome assembly (GO:0034080)4.50436344
16mitotic recombination (GO:0006312)4.45649812
17metaphase plate congression (GO:0051310)4.43723659
18chromatin remodeling at centromere (GO:0031055)4.42921537
19mitotic nuclear envelope disassembly (GO:0007077)4.34574375
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33418329
21telomere maintenance via recombination (GO:0000722)4.31291778
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.29589056
23regulation of spindle organization (GO:0090224)4.28343528
24DNA replication checkpoint (GO:0000076)4.28064398
25DNA replication-dependent nucleosome organization (GO:0034723)4.25882814
26DNA replication-dependent nucleosome assembly (GO:0006335)4.25882814
27nuclear pore organization (GO:0006999)4.23777727
28kinetochore assembly (GO:0051382)4.23753038
29establishment of chromosome localization (GO:0051303)4.16742298
30nuclear pore complex assembly (GO:0051292)4.12724333
31DNA replication-independent nucleosome assembly (GO:0006336)4.12578947
32DNA replication-independent nucleosome organization (GO:0034724)4.12578947
33membrane disassembly (GO:0030397)4.03305257
34nuclear envelope disassembly (GO:0051081)4.03305257
35positive regulation of chromosome segregation (GO:0051984)3.89453590
36protein localization to chromosome (GO:0034502)3.88575721
37meiotic chromosome segregation (GO:0045132)3.88377632
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81566699
39spindle checkpoint (GO:0031577)3.80777602
40telomere maintenance via telomere lengthening (GO:0010833)3.76772626
41regulation of chromosome segregation (GO:0051983)3.76741904
42histone exchange (GO:0043486)3.76027344
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.74412702
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.70545574
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.70545574
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.70545574
47DNA geometric change (GO:0032392)3.68483220
48DNA duplex unwinding (GO:0032508)3.68067321
49negative regulation of chromosome segregation (GO:0051985)3.65381625
50spindle assembly checkpoint (GO:0071173)3.64953067
51chromosome segregation (GO:0007059)3.64067659
52regulation of mitotic spindle organization (GO:0060236)3.64036188
53regulation of sister chromatid cohesion (GO:0007063)3.62822104
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.60804154
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.60804154
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.60804154
57negative regulation of sister chromatid segregation (GO:0033046)3.60804154
58mitotic sister chromatid cohesion (GO:0007064)3.60688772
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.59187652
60DNA topological change (GO:0006265)3.58694597
61DNA synthesis involved in DNA repair (GO:0000731)3.56801998
62microtubule depolymerization (GO:0007019)3.55797041
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.51915260
64mitotic spindle assembly checkpoint (GO:0007094)3.51556839
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.51345279
66chromatin assembly or disassembly (GO:0006333)3.49901924
67establishment of viral latency (GO:0019043)3.46270400
68regulation of centrosome cycle (GO:0046605)3.45557957
69nucleobase biosynthetic process (GO:0046112)3.45348188
70mitotic spindle checkpoint (GO:0071174)3.44053766
71regulation of sister chromatid segregation (GO:0033045)3.42076766
72regulation of mitotic sister chromatid separation (GO:0010965)3.42076766
73regulation of mitotic sister chromatid segregation (GO:0033047)3.42076766
74IMP biosynthetic process (GO:0006188)3.40990135
75heterochromatin organization (GO:0070828)3.39794580
76ribosomal small subunit assembly (GO:0000028)3.33713482
77formation of translation preinitiation complex (GO:0001731)3.31781352
78* chromosome condensation (GO:0030261)3.30568419
79folic acid-containing compound biosynthetic process (GO:0009396)3.27147119
80* DNA conformation change (GO:0071103)3.26553958
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.25546883
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25546883
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23867548
84ATP-dependent chromatin remodeling (GO:0043044)3.23771566
85double-strand break repair via nonhomologous end joining (GO:0006303)3.23690279
86non-recombinational repair (GO:0000726)3.23690279
87pore complex assembly (GO:0046931)3.17792448
88ribosomal small subunit biogenesis (GO:0042274)3.16006112
89nuclear envelope organization (GO:0006998)3.14432861
90negative regulation of mitosis (GO:0045839)3.13247419
91purine nucleobase biosynthetic process (GO:0009113)3.13117611
92regulation of centriole replication (GO:0046599)3.12284589
93histone-serine phosphorylation (GO:0035404)3.10785972
94telomere maintenance (GO:0000723)3.10507565
95regulation of histone H3-K9 methylation (GO:0051570)3.09760021
96* mitotic cell cycle (GO:0000278)3.09112433
97translesion synthesis (GO:0019985)3.09111919
98telomere organization (GO:0032200)3.08852749
99* chromosome organization (GO:0051276)3.05010703
100protein K6-linked ubiquitination (GO:0085020)3.04772332
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.04452370
102maturation of SSU-rRNA (GO:0030490)3.04141098
103IMP metabolic process (GO:0046040)3.01580258
104mismatch repair (GO:0006298)3.00011145
105protein complex localization (GO:0031503)2.99942725
106postreplication repair (GO:0006301)2.99785278
107regulation of DNA endoreduplication (GO:0032875)2.99579236
108regulation of translational fidelity (GO:0006450)2.98838044
109mitotic G2/M transition checkpoint (GO:0044818)2.98697061
110* DNA packaging (GO:0006323)2.98480578
111base-excision repair (GO:0006284)2.96913421
112DNA ligation (GO:0006266)2.95533117
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93558029
114regulation of centrosome duplication (GO:0010824)2.87119441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.46926579
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.67906609
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.08548655
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.72438459
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37399733
6AR_21909140_ChIP-Seq_LNCAP_Human2.75762918
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66921419
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57403049
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.53918910
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53333642
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.39829554
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.39293109
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34616333
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34040158
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25483408
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18579887
17XRN2_22483619_ChIP-Seq_HELA_Human2.12514180
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11774194
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06317777
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.04615059
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03540876
22E2F7_22180533_ChIP-Seq_HELA_Human10.6347601
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.98115734
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96430490
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85655679
26VDR_23849224_ChIP-Seq_CD4+_Human1.81539292
27MYC_22102868_ChIP-Seq_BL_Human1.76452609
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74321953
29FOXP3_21729870_ChIP-Seq_TREG_Human1.71148268
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69597718
31DCP1A_22483619_ChIP-Seq_HELA_Human1.67174503
32CIITA_25753668_ChIP-Seq_RAJI_Human1.66806810
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64307423
34TTF2_22483619_ChIP-Seq_HELA_Human1.62341576
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62212255
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59924790
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58932327
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50267429
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49925259
40GABP_19822575_ChIP-Seq_HepG2_Human1.49878289
41ELK1_19687146_ChIP-ChIP_HELA_Human1.48916134
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47634431
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47561964
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45037193
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43785273
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42380382
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41574697
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39183288
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38763615
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.35603989
51KDM5A_27292631_Chip-Seq_BREAST_Human1.34018547
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33598070
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30251191
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28256472
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27522607
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26978334
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25817763
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22017630
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21785031
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16912945
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16313498
62VDR_21846776_ChIP-Seq_THP-1_Human1.13426880
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13130039
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12644647
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12541134
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12289118
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09969769
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09837864
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08569478
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05355662
71TFEB_21752829_ChIP-Seq_HELA_Human1.04499912
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03651862
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03591822
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.03189857
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00844177
76SALL1_21062744_ChIP-ChIP_HESCs_Human0.96248953
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95328156
78NANOG_21062744_ChIP-ChIP_HESCs_Human0.94607638
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93378403
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93183356
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92990907
82* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92010544
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91680294
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89949140
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89653784
86MYC_18940864_ChIP-ChIP_HL60_Human0.88749679
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85776360
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85200608
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.85178186
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84574388
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.83039424
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82453415
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81783815
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81151785
95* SPI1_23547873_ChIP-Seq_NB4_Human0.80337843
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79171463
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78246571
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76547197
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76345392
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75643066
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74785467
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.74652462
103ZNF263_19887448_ChIP-Seq_K562_Human0.73974305
104CHD1_26751641_Chip-Seq_LNCaP_Human0.73124148
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72638082
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72414133
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72413018
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70841840
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.68342701
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65375931
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.64232935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.11167873
2MP0010094_abnormal_chromosome_stability5.02172921
3MP0003111_abnormal_nucleus_morphology4.68382673
4MP0003077_abnormal_cell_cycle4.20026968
5MP0004957_abnormal_blastocyst_morpholog4.17037159
6MP0008057_abnormal_DNA_replication3.94442445
7MP0008058_abnormal_DNA_repair3.00449467
8MP0008007_abnormal_cellular_replicative2.86917029
9MP0008932_abnormal_embryonic_tissue2.60377341
10MP0006292_abnormal_olfactory_placode2.40828226
11MP0001730_embryonic_growth_arrest2.37228037
12MP0003123_paternal_imprinting2.34767009
13MP0000350_abnormal_cell_proliferation2.32818493
14MP0010352_gastrointestinal_tract_polyps2.31568571
15MP0010307_abnormal_tumor_latency2.20790310
16MP0002396_abnormal_hematopoietic_system2.16249087
17MP0008877_abnormal_DNA_methylation1.97183173
18MP0009697_abnormal_copulation1.95059361
19MP0005380_embryogenesis_phenotype1.82332891
20MP0001672_abnormal_embryogenesis/_devel1.82332891
21MP0001697_abnormal_embryo_size1.82008185
22MP0005076_abnormal_cell_differentiation1.70835648
23MP0004808_abnormal_hematopoietic_stem1.68912158
24MP0002085_abnormal_embryonic_tissue1.65809992
25MP0000490_abnormal_crypts_of1.65050618
26MP0003984_embryonic_growth_retardation1.63444740
27MP0002080_prenatal_lethality1.60874992
28MP0003121_genomic_imprinting1.59893361
29MP0002088_abnormal_embryonic_growth/wei1.59758847
30MP0010030_abnormal_orbit_morphology1.55044750
31MP0002877_abnormal_melanocyte_morpholog1.53859166
32MP0002084_abnormal_developmental_patter1.52052416
33MP0004197_abnormal_fetal_growth/weight/1.51701027
34MP0002086_abnormal_extraembryonic_tissu1.50467301
35MP0003705_abnormal_hypodermis_morpholog1.50033766
36MP0006054_spinal_hemorrhage1.47110355
37MP0003786_premature_aging1.46635098
38MP0000313_abnormal_cell_death1.44910364
39MP0002019_abnormal_tumor_incidence1.43780014
40MP0009379_abnormal_foot_pigmentation1.42215221
41MP0009053_abnormal_anal_canal1.40609037
42MP0003567_abnormal_fetal_cardiomyocyte1.39341047
43MP0000566_synostosis1.38216282
44MP0003890_abnormal_embryonic-extraembry1.33823583
45MP0005397_hematopoietic_system_phenotyp1.20292607
46MP0001545_abnormal_hematopoietic_system1.20292607
47MP0001293_anophthalmia1.18213555
48MP0009278_abnormal_bone_marrow1.17598849
49MP0000703_abnormal_thymus_morphology1.17438638
50MP0003315_abnormal_perineum_morphology1.14463910
51MP0000537_abnormal_urethra_morphology1.14294649
52MP0001346_abnormal_lacrimal_gland1.11932926
53MP0003718_maternal_effect1.09564915
54MP0002210_abnormal_sex_determination1.05849682
55MP0006035_abnormal_mitochondrial_morpho1.04058706
56MP0002398_abnormal_bone_marrow1.03870939
57MP0009333_abnormal_splenocyte_physiolog1.00307088
58MP0003136_yellow_coat_color1.00174159
59MP0008789_abnormal_olfactory_epithelium0.99140485
60MP0002722_abnormal_immune_system0.97789045
61MP0003806_abnormal_nucleotide_metabolis0.94282218
62MP0001145_abnormal_male_reproductive0.92676380
63MP0004185_abnormal_adipocyte_glucose0.91458254
64MP0003119_abnormal_digestive_system0.91150773
65MP0009672_abnormal_birth_weight0.90410919
66MP0003937_abnormal_limbs/digits/tail_de0.90106406
67MP0005023_abnormal_wound_healing0.89776766
68MP0000689_abnormal_spleen_morphology0.89757232
69MP0002111_abnormal_tail_morphology0.89056251
70MP0003763_abnormal_thymus_physiology0.88380475
71MP0002233_abnormal_nose_morphology0.87289305
72MP0001915_intracranial_hemorrhage0.87032335
73MP0003699_abnormal_female_reproductive0.85956851
74MP0005501_abnormal_skin_physiology0.83895362
75MP0003566_abnormal_cell_adhesion0.83011332
76MP0005394_taste/olfaction_phenotype0.81856353
77MP0005499_abnormal_olfactory_system0.81856353
78MP0001849_ear_inflammation0.81668366
79MP0001929_abnormal_gametogenesis0.80899174
80MP0009703_decreased_birth_body0.78834038
81MP0003115_abnormal_respiratory_system0.77960087
82MP0000653_abnormal_sex_gland0.77521417
83MP0001727_abnormal_embryo_implantation0.77495880
84MP0002429_abnormal_blood_cell0.76743684
85MP0003941_abnormal_skin_development0.76728283
86MP0002092_abnormal_eye_morphology0.76496272
87MP0003861_abnormal_nervous_system0.76400640
88MP0002161_abnormal_fertility/fecundity0.76159897
89MP0001119_abnormal_female_reproductive0.75710065
90MP0005621_abnormal_cell_physiology0.75681340
91MP0000733_abnormal_muscle_development0.75509254
92MP0005384_cellular_phenotype0.75437833
93MP0000858_altered_metastatic_potential0.75068395
94MP0004147_increased_porphyrin_level0.72905032
95MP0000428_abnormal_craniofacial_morphol0.72620629
96MP0001286_abnormal_eye_development0.69632603
97MP0003698_abnormal_male_reproductive0.68982487
98MP0000477_abnormal_intestine_morphology0.68163045
99MP0005395_other_phenotype0.66162599
100MP0002160_abnormal_reproductive_system0.65764412
101MP0002938_white_spotting0.65571838
102MP0000049_abnormal_middle_ear0.65369932
103MP0002925_abnormal_cardiovascular_devel0.64475230
104MP0005408_hypopigmentation0.63430497
105MP0003755_abnormal_palate_morphology0.63076980
106MP0002234_abnormal_pharynx_morphology0.62979847
107MP0002697_abnormal_eye_size0.62897755
108MP0001881_abnormal_mammary_gland0.62494637
109MP0000432_abnormal_head_morphology0.62445149
110MP0000716_abnormal_immune_system0.61197485
111MP0000372_irregular_coat_pigmentation0.61073028
112MP0002163_abnormal_gland_morphology0.60490553
113MP0003935_abnormal_craniofacial_develop0.59544872
114MP0001529_abnormal_vocalization0.59265023
115MP0002932_abnormal_joint_morphology0.59203009
116MP0008995_early_reproductive_senescence0.57986639
117MP0002282_abnormal_trachea_morphology0.57842173
118MP0003950_abnormal_plasma_membrane0.57410514
119MP0004133_heterotaxia0.57392203
120MP0004264_abnormal_extraembryonic_tissu0.57073593
121MP0000358_abnormal_cell_content/0.56616548
122MP0002653_abnormal_ependyma_morphology0.56384437
123MP0002796_impaired_skin_barrier0.56148096
124MP0003656_abnormal_erythrocyte_physiolo0.55902689
125MP0002095_abnormal_skin_pigmentation0.55727878
126MP0003943_abnormal_hepatobiliary_system0.55110039
127MP0005389_reproductive_system_phenotype0.54393215
128MP0003186_abnormal_redox_activity0.54023855
129MP0004233_abnormal_muscle_weight0.53354682
130MP0000678_abnormal_parathyroid_gland0.52811932
131MP0003385_abnormal_body_wall0.52489835
132MP0003938_abnormal_ear_development0.52319077
133MP0000266_abnormal_heart_morphology0.52316392
134MP0003448_altered_tumor_morphology0.52058040
135MP0001919_abnormal_reproductive_system0.50390618
136MP0003942_abnormal_urinary_system0.49880915
137MP0002075_abnormal_coat/hair_pigmentati0.49684452

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.14373403
2Birth length less than 3rd percentile (HP:0003561)4.01476110
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89416352
4Reticulocytopenia (HP:0001896)3.66726957
5Colon cancer (HP:0003003)3.39469578
6Abnormality of chromosome stability (HP:0003220)3.38972395
7Meckel diverticulum (HP:0002245)3.22534980
8Medulloblastoma (HP:0002885)3.20678459
9Patellar aplasia (HP:0006443)3.20266127
10Increased nuchal translucency (HP:0010880)3.18682057
11Selective tooth agenesis (HP:0001592)3.17872224
12Ependymoma (HP:0002888)3.11212340
13Abnormality of the ileum (HP:0001549)3.09032560
14Aplasia/Hypoplasia of the patella (HP:0006498)3.06338005
15Duodenal stenosis (HP:0100867)3.05126751
16Small intestinal stenosis (HP:0012848)3.05126751
17Breast hypoplasia (HP:0003187)3.04999905
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.01294778
19Abnormal lung lobation (HP:0002101)2.99494872
20Abnormality of the preputium (HP:0100587)2.95478347
21Cortical dysplasia (HP:0002539)2.91944925
22Ectopic kidney (HP:0000086)2.91756326
23Volvulus (HP:0002580)2.89721222
24Short 4th metacarpal (HP:0010044)2.87934857
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87934857
26Impulsivity (HP:0100710)2.81740455
27Degeneration of anterior horn cells (HP:0002398)2.74552892
28Abnormality of the anterior horn cell (HP:0006802)2.74552892
29Myelodysplasia (HP:0002863)2.73146843
30Microvesicular hepatic steatosis (HP:0001414)2.65889012
31Absent radius (HP:0003974)2.63512654
32Multiple enchondromatosis (HP:0005701)2.63173269
33Agnosia (HP:0010524)2.62065220
34Proximal placement of thumb (HP:0009623)2.60902030
3511 pairs of ribs (HP:0000878)2.59116635
36Absent thumb (HP:0009777)2.58142286
37Oral leukoplakia (HP:0002745)2.56856151
38Rhabdomyosarcoma (HP:0002859)2.56698711
39Carpal bone hypoplasia (HP:0001498)2.56186347
40Deviation of the thumb (HP:0009603)2.55781683
41Abnormality of the duodenum (HP:0002246)2.53503199
42Abnormality of cells of the erythroid lineage (HP:0012130)2.53362271
43Nephroblastoma (Wilms tumor) (HP:0002667)2.52084778
44Abnormality of cochlea (HP:0000375)2.48768910
45Abnormal number of erythroid precursors (HP:0012131)2.45051983
46Aplasia involving forearm bones (HP:0009822)2.44256101
47Absent forearm bone (HP:0003953)2.44256101
48Sloping forehead (HP:0000340)2.43061362
49Abnormality of glycolysis (HP:0004366)2.42051594
50Abnormal number of incisors (HP:0011064)2.39248501
51Embryonal renal neoplasm (HP:0011794)2.37537958
52Basal cell carcinoma (HP:0002671)2.34893512
53Progressive muscle weakness (HP:0003323)2.31173978
54High pitched voice (HP:0001620)2.31159199
55Duplication of thumb phalanx (HP:0009942)2.30878695
56Atresia of the external auditory canal (HP:0000413)2.30404929
57Neoplasm of the pancreas (HP:0002894)2.30280378
58Abnormality of the labia minora (HP:0012880)2.30056599
59Cafe-au-lait spot (HP:0000957)2.28442292
60Abnormality of the carotid arteries (HP:0005344)2.27175954
61Increased serum pyruvate (HP:0003542)2.25351769
62Bone marrow hypocellularity (HP:0005528)2.20737711
63High anterior hairline (HP:0009890)2.18240639
64Choanal atresia (HP:0000453)2.18078161
65Progressive external ophthalmoplegia (HP:0000590)2.16750762
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.16124874
67Astrocytoma (HP:0009592)2.15512600
68Abnormality of the astrocytes (HP:0100707)2.15512600
69Embryonal neoplasm (HP:0002898)2.14444067
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13861294
71Tracheoesophageal fistula (HP:0002575)2.11863979
72Missing ribs (HP:0000921)2.09768247
73Aplastic anemia (HP:0001915)2.08287614
74Short thumb (HP:0009778)2.07385136
75Broad distal phalanx of finger (HP:0009836)2.05288417
76Neoplasm of the colon (HP:0100273)2.04304155
77Horseshoe kidney (HP:0000085)2.03692570
78Glioma (HP:0009733)2.01915856
79Facial hemangioma (HP:0000329)2.00779961
80Abnormality of the calcaneus (HP:0008364)2.00529209
81Duplicated collecting system (HP:0000081)1.99632576
82Premature graying of hair (HP:0002216)1.99512770
83Neoplasm of striated muscle (HP:0009728)1.98705018
84Arteriovenous malformation (HP:0100026)1.98079610
85Rough bone trabeculation (HP:0100670)1.97821543
86Abnormality of the 4th metacarpal (HP:0010012)1.97511052
87Prominent nose (HP:0000448)1.97059540
88Ovarian neoplasm (HP:0100615)1.96379334
89Supernumerary spleens (HP:0009799)1.96169001
90Triphalangeal thumb (HP:0001199)1.95954450
91Hypoplastic pelvis (HP:0008839)1.93444797
92Morphological abnormality of the inner ear (HP:0011390)1.88286678
93Abnormality of the renal collecting system (HP:0004742)1.87195553
94Squamous cell carcinoma (HP:0002860)1.85809111
95Neoplasm of the oral cavity (HP:0100649)1.84565589
96Pallor (HP:0000980)1.84534546
97Cellular immunodeficiency (HP:0005374)1.84186822
98Abnormality of DNA repair (HP:0003254)1.83493865
99Absent epiphyses (HP:0010577)1.82187871
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82187871
101Deep philtrum (HP:0002002)1.81026911
102Cholecystitis (HP:0001082)1.80951489
103Abnormal gallbladder physiology (HP:0012438)1.80951489
104Abnormality of reticulocytes (HP:0004312)1.79990758
105Renal duplication (HP:0000075)1.79230086
106Overlapping toe (HP:0001845)1.78178578
107Lymphoma (HP:0002665)1.78096016
108Septo-optic dysplasia (HP:0100842)1.77919793
109Clubbing of toes (HP:0100760)1.77794344
110Pancytopenia (HP:0001876)1.77745909
111Malignant gastrointestinal tract tumors (HP:0006749)1.77600025
112Gastrointestinal carcinoma (HP:0002672)1.77600025
113Abnormality of the septum pellucidum (HP:0007375)1.76761846
114Abnormality of chromosome segregation (HP:0002916)1.76621491
115Biliary tract neoplasm (HP:0100574)1.76229263
116Microretrognathia (HP:0000308)1.76160352
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75803493
118Facial cleft (HP:0002006)1.75015718
119Absent septum pellucidum (HP:0001331)1.74920985
120Abnormal umbilical cord blood vessels (HP:0011403)1.72984828
121Single umbilical artery (HP:0001195)1.72984828
122Abnormality of the fetal cardiovascular system (HP:0010948)1.72984828
123Short middle phalanx of the 5th finger (HP:0004220)1.72704469
124Long eyelashes (HP:0000527)1.70782616
125Amaurosis fugax (HP:0100576)1.70532058
126Abnormality of abdominal situs (HP:0011620)1.70089169
127Abdominal situs inversus (HP:0003363)1.70089169
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70005615
129Macrocytic anemia (HP:0001972)1.69905988
130Poikiloderma (HP:0001029)1.68664632
131Abnormality of the umbilical cord (HP:0010881)1.64296643
132Premature ovarian failure (HP:0008209)1.63483711
133Irregular epiphyses (HP:0010582)1.62134535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.84974929
2BUB14.74392346
3WEE14.17153359
4NEK23.49169919
5NEK12.75726480
6VRK22.75669060
7BRSK22.72799566
8TTK2.70525688
9EIF2AK12.44515598
10BRSK12.19929208
11PLK12.18899082
12CDK122.12467389
13AURKB2.02589011
14SRPK11.98424385
15PLK41.98036281
16STK101.97876223
17ACVR1B1.84099346
18EEF2K1.76185250
19ATR1.73915196
20TLK11.73462523
21MKNK11.72218652
22STK41.69627817
23PASK1.68907074
24CCNB11.65774784
25TESK21.64918595
26MAP3K101.64618191
27PLK31.63152832
28SMG11.59879769
29MAP3K81.59600190
30CHEK21.58057087
31RPS6KA41.55813878
32CDK71.53197525
33CDK41.50859753
34VRK11.49436899
35TAF11.49156178
36TSSK61.45296770
37RPS6KB21.44842414
38MELK1.35509158
39AURKA1.32918547
40CHEK11.32038914
41TGFBR11.18551451
42DYRK31.12986947
43SCYL21.12456615
44CDK61.11109268
45PAK41.09816677
46PKN21.09681147
47MKNK21.01236451
48EIF2AK31.01217246
49CLK10.99544141
50ATM0.97713195
51NME20.96262202
52PNCK0.96246578
53BRD40.94924810
54ZAK0.92621845
55NME10.87669743
56* CDK20.86520249
57STK30.86160541
58MAP4K10.79890007
59STK160.77772128
60PBK0.76270106
61PIM10.75584597
62CDK10.75146431
63LRRK20.74530160
64NEK90.66300574
65EPHA20.66112110
66EIF2AK20.65906576
67TESK10.65629141
68CDK80.59870076
69ICK0.56823022
70PAK10.54976042
71FLT30.53294446
72ALK0.52798805
73IRAK30.50593919
74* CSNK2A10.49860581
75TRIM280.49832269
76LATS20.49814201
77MST1R0.49488822
78CSNK2A20.48794685
79PDK20.48678113
80ERBB40.47750225
81RPS6KA50.47483250
82CAMK1D0.46751763
83MET0.46604361
84CAMK1G0.45546156
85KDR0.45532970
86MTOR0.45079940
87NUAK10.44367059
88TRIB30.43138663
89MARK30.41742756
90MAP3K90.40747641
91CDK140.38196924
92GRK60.37370514
93PRKDC0.36252385
94AKT20.35475689
95RAF10.34139473
96BTK0.33860312
97TTN0.33080483
98MAPK110.32903135
99CDK90.32064639
100LATS10.31403944
101PRKCI0.30767236
102CDK30.30001561
103BRAF0.29300481
104MAPK140.28925153
105ARAF0.28057437
106CSF1R0.27991933
107MAPKAPK20.27665615
108FGFR10.26410625
109CSNK1D0.24187159
110AKT10.23863060
111KSR10.23228203
112PAK20.22773967
113KSR20.20839889
114MST40.20709368
115GSK3B0.20634853
116DYRK1B0.19286270
117MAP2K30.18904048
118CDK11A0.18763249
119YES10.18394885
120ILK0.18123708
121CDK150.17659755
122CSNK1E0.17614941
123MAPK10.17600023
124PRPF4B0.17071413
125CDK180.16490390

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.43704982
2Mismatch repair_Homo sapiens_hsa034304.56671048
3Base excision repair_Homo sapiens_hsa034103.52520989
4Cell cycle_Homo sapiens_hsa041103.46881214
5Homologous recombination_Homo sapiens_hsa034403.35768951
6Spliceosome_Homo sapiens_hsa030403.17694766
7RNA transport_Homo sapiens_hsa030132.99053687
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96450136
9Nucleotide excision repair_Homo sapiens_hsa034202.90052861
10One carbon pool by folate_Homo sapiens_hsa006702.65158472
11Fanconi anemia pathway_Homo sapiens_hsa034602.58689991
12Non-homologous end-joining_Homo sapiens_hsa034502.47411337
13Ribosome_Homo sapiens_hsa030102.45531011
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27150753
15Proteasome_Homo sapiens_hsa030502.22534388
16RNA polymerase_Homo sapiens_hsa030202.05650432
17Pyrimidine metabolism_Homo sapiens_hsa002401.99674320
18Systemic lupus erythematosus_Homo sapiens_hsa053221.88744677
19mRNA surveillance pathway_Homo sapiens_hsa030151.84830392
20RNA degradation_Homo sapiens_hsa030181.84633292
21p53 signaling pathway_Homo sapiens_hsa041151.81947553
22Basal transcription factors_Homo sapiens_hsa030221.58591048
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53597282
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32806964
25Oocyte meiosis_Homo sapiens_hsa041141.32380396
26Viral carcinogenesis_Homo sapiens_hsa052031.31325729
27Pyruvate metabolism_Homo sapiens_hsa006201.21657969
28Epstein-Barr virus infection_Homo sapiens_hsa051691.15759500
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09275381
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07418426
31Protein export_Homo sapiens_hsa030601.06044887
32HTLV-I infection_Homo sapiens_hsa051661.04443278
33Herpes simplex infection_Homo sapiens_hsa051681.04209334
34MicroRNAs in cancer_Homo sapiens_hsa052061.01527920
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97649904
36Purine metabolism_Homo sapiens_hsa002300.96377504
37Huntingtons disease_Homo sapiens_hsa050160.96081678
38Antigen processing and presentation_Homo sapiens_hsa046120.95013047
39Small cell lung cancer_Homo sapiens_hsa052220.92216710
40Parkinsons disease_Homo sapiens_hsa050120.90053644
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88204290
42Steroid biosynthesis_Homo sapiens_hsa001000.85155199
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81028677
44Alcoholism_Homo sapiens_hsa050340.79827703
45Oxidative phosphorylation_Homo sapiens_hsa001900.79501163
46Thyroid cancer_Homo sapiens_hsa052160.75751243
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74710845
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73843250
49Primary immunodeficiency_Homo sapiens_hsa053400.73396029
50Sulfur relay system_Homo sapiens_hsa041220.67598708
51Chronic myeloid leukemia_Homo sapiens_hsa052200.66199575
52Biosynthesis of amino acids_Homo sapiens_hsa012300.65886886
53Selenocompound metabolism_Homo sapiens_hsa004500.64663484
54Colorectal cancer_Homo sapiens_hsa052100.64541512
55Pentose phosphate pathway_Homo sapiens_hsa000300.64367656
56Fatty acid elongation_Homo sapiens_hsa000620.63845146
57Basal cell carcinoma_Homo sapiens_hsa052170.61403492
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60603565
59Hippo signaling pathway_Homo sapiens_hsa043900.60502301
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58911445
61Apoptosis_Homo sapiens_hsa042100.57452014
62Notch signaling pathway_Homo sapiens_hsa043300.55834612
63Hepatitis B_Homo sapiens_hsa051610.55728756
64TGF-beta signaling pathway_Homo sapiens_hsa043500.55706999
65Legionellosis_Homo sapiens_hsa051340.54160940
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53944707
67Bladder cancer_Homo sapiens_hsa052190.53633891
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.52964950
69Viral myocarditis_Homo sapiens_hsa054160.52847052
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52574127
71Adherens junction_Homo sapiens_hsa045200.50684266
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47621797
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47378306
74Measles_Homo sapiens_hsa051620.47212559
75Shigellosis_Homo sapiens_hsa051310.46235643
76Propanoate metabolism_Homo sapiens_hsa006400.46215605
77Pancreatic cancer_Homo sapiens_hsa052120.44715721
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.44707731
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.43539187
80Lysine degradation_Homo sapiens_hsa003100.40045059
81Fructose and mannose metabolism_Homo sapiens_hsa000510.39801758
82Pathways in cancer_Homo sapiens_hsa052000.38946057
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.38474934
84Alzheimers disease_Homo sapiens_hsa050100.37701598
85Prostate cancer_Homo sapiens_hsa052150.37547694
86Non-small cell lung cancer_Homo sapiens_hsa052230.36685991
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36482241
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36321737
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34863526
90HIF-1 signaling pathway_Homo sapiens_hsa040660.33655571
91Galactose metabolism_Homo sapiens_hsa000520.32891205
92Influenza A_Homo sapiens_hsa051640.32496489
93N-Glycan biosynthesis_Homo sapiens_hsa005100.32366202
94Metabolic pathways_Homo sapiens_hsa011000.32244529
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31338615
96Hematopoietic cell lineage_Homo sapiens_hsa046400.30823149
97Folate biosynthesis_Homo sapiens_hsa007900.30648836
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.30035776
99mTOR signaling pathway_Homo sapiens_hsa041500.29305502
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.28948855
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28680693
102Carbon metabolism_Homo sapiens_hsa012000.28634131
103Proteoglycans in cancer_Homo sapiens_hsa052050.28136551
104Hedgehog signaling pathway_Homo sapiens_hsa043400.27505340
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26915889
106Vitamin B6 metabolism_Homo sapiens_hsa007500.26318172
107Glutathione metabolism_Homo sapiens_hsa004800.25611784
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25507607
109B cell receptor signaling pathway_Homo sapiens_hsa046620.25010191
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24126639
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23996824
112FoxO signaling pathway_Homo sapiens_hsa040680.22110291
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.21876300
114Acute myeloid leukemia_Homo sapiens_hsa052210.20294650
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19730000
116Renin-angiotensin system_Homo sapiens_hsa046140.18998663
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17745290
118Melanoma_Homo sapiens_hsa052180.17276641
119Wnt signaling pathway_Homo sapiens_hsa043100.16946719
120Leishmaniasis_Homo sapiens_hsa051400.16821104
121Endometrial cancer_Homo sapiens_hsa052130.16096523
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13916986
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12989843
124Tight junction_Homo sapiens_hsa045300.11709823
125Arginine and proline metabolism_Homo sapiens_hsa003300.11664219
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10231940
127Fatty acid metabolism_Homo sapiens_hsa012120.09855332
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09329128

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