NCAPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)6.02486940
2DNA unwinding involved in DNA replication (GO:0006268)5.47159989
3DNA strand elongation involved in DNA replication (GO:0006271)5.16639428
4viral transcription (GO:0019083)5.11143201
5ribosomal small subunit assembly (GO:0000028)5.07900967
6sulfur amino acid catabolic process (GO:0000098)5.04881081
7purine nucleotide salvage (GO:0032261)4.96531597
8protein localization to kinetochore (GO:0034501)4.96036516
9L-serine metabolic process (GO:0006563)4.95276529
10translational termination (GO:0006415)4.94302560
11DNA strand elongation (GO:0022616)4.88461695
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.82774912
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.82774912
14telomere maintenance via semi-conservative replication (GO:0032201)4.75925484
15mitochondrial RNA metabolic process (GO:0000959)4.71975475
16translational elongation (GO:0006414)4.58765777
17microtubule nucleation (GO:0007020)4.57599269
18DNA replication initiation (GO:0006270)4.50725671
19formation of translation preinitiation complex (GO:0001731)4.44907433
20alternative mRNA splicing, via spliceosome (GO:0000380)4.42730212
21maturation of SSU-rRNA (GO:0030490)4.31848935
22folic acid metabolic process (GO:0046655)4.31451629
23regulation of plasminogen activation (GO:0010755)4.29924471
24translational initiation (GO:0006413)4.24237824
25peptidyl-arginine N-methylation (GO:0035246)4.23188142
26peptidyl-arginine methylation (GO:0018216)4.23188142
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.19236188
28mitotic sister chromatid segregation (GO:0000070)4.16554549
29protein localization to chromosome, centromeric region (GO:0071459)4.13116292
30histone arginine methylation (GO:0034969)4.12876360
31cysteine metabolic process (GO:0006534)4.11996087
32telomere maintenance via recombination (GO:0000722)4.09606174
33DNA replication-dependent nucleosome organization (GO:0034723)4.04405909
34DNA replication-dependent nucleosome assembly (GO:0006335)4.04405909
35mitotic recombination (GO:0006312)4.04257525
36folic acid-containing compound biosynthetic process (GO:0009396)4.02636134
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.02580737
38negative regulation of cell size (GO:0045792)3.99990309
39mitotic nuclear envelope disassembly (GO:0007077)3.98374370
40ribosomal small subunit biogenesis (GO:0042274)3.96689634
41cellular protein complex disassembly (GO:0043624)3.94031761
42sister chromatid segregation (GO:0000819)3.92314685
43pteridine-containing compound biosynthetic process (GO:0042559)3.90872059
44protein targeting to ER (GO:0045047)3.90506982
45cotranslational protein targeting to membrane (GO:0006613)3.89522008
46serine family amino acid biosynthetic process (GO:0009070)3.89437824
47viral life cycle (GO:0019058)3.85951112
48ribosomal large subunit biogenesis (GO:0042273)3.85626596
49folic acid-containing compound metabolic process (GO:0006760)3.82446382
50DNA replication checkpoint (GO:0000076)3.79054703
51nucleobase biosynthetic process (GO:0046112)3.76306346
52tRNA modification (GO:0006400)3.74693268
53telomere maintenance via telomere lengthening (GO:0010833)3.73131695
54nuclear envelope disassembly (GO:0051081)3.72148814
55membrane disassembly (GO:0030397)3.72148814
56nucleotide salvage (GO:0043173)3.71801670
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69778278
58galactose catabolic process (GO:0019388)3.68170791
59protein complex disassembly (GO:0043241)3.65748271
60mitotic chromosome condensation (GO:0007076)3.65233255
61guanosine-containing compound biosynthetic process (GO:1901070)3.64585515
62protein localization to endoplasmic reticulum (GO:0070972)3.64062944
63tetrahydrofolate metabolic process (GO:0046653)3.63281578
64mitotic metaphase plate congression (GO:0007080)3.62814390
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.59947330
66IMP biosynthetic process (GO:0006188)3.53475290
67cellular protein complex localization (GO:0034629)3.51356463
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51276510
69white fat cell differentiation (GO:0050872)3.46454516
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43847695
71macromolecular complex disassembly (GO:0032984)3.42478826
72viral mRNA export from host cell nucleus (GO:0046784)3.41490460
73DNA duplex unwinding (GO:0032508)3.37796759
74GMP metabolic process (GO:0046037)3.37562779
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.37524318
76phosphatidylglycerol biosynthetic process (GO:0006655)3.37387165
77ribonucleoprotein complex biogenesis (GO:0022613)3.36610900
78regulation of spindle organization (GO:0090224)3.36609288
79regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35946891
80DNA geometric change (GO:0032392)3.35899867
81DNA ligation (GO:0006266)3.35753796
82spliceosomal tri-snRNP complex assembly (GO:0000244)3.32850463
83pseudouridine synthesis (GO:0001522)3.31805249
84purine nucleobase biosynthetic process (GO:0009113)3.31471545
85protein complex localization (GO:0031503)3.29238931
86nuclear pore organization (GO:0006999)3.27878976
87histone H4-K12 acetylation (GO:0043983)3.27327299
88DNA deamination (GO:0045006)3.26105454
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25531478
90regulation of translational fidelity (GO:0006450)3.24754568
91negative regulation of RNA splicing (GO:0033119)3.24495766
92CENP-A containing nucleosome assembly (GO:0034080)3.23381535
93DNA synthesis involved in DNA repair (GO:0000731)3.21831783
94nuclear-transcribed mRNA catabolic process (GO:0000956)3.20485773
95chromatin remodeling at centromere (GO:0031055)3.19315736
96metaphase plate congression (GO:0051310)3.15290759
97proline biosynthetic process (GO:0006561)3.11756421
98negative regulation of telomerase activity (GO:0051974)3.11298590
99DNA replication-independent nucleosome organization (GO:0034724)3.10094888
100DNA replication-independent nucleosome assembly (GO:0006336)3.10094888
101negative regulation of DNA biosynthetic process (GO:2000279)3.08966920
102ribosome biogenesis (GO:0042254)3.08391021
103tRNA methylation (GO:0030488)3.07559308
104spliceosomal snRNP assembly (GO:0000387)3.07028752
105attachment of spindle microtubules to kinetochore (GO:0008608)3.04657283
106positive regulation of chromosome segregation (GO:0051984)3.04325942
107IMP metabolic process (GO:0046040)3.03732294
108nuclear envelope organization (GO:0006998)3.03472900
109mRNA catabolic process (GO:0006402)3.01463371
110kinetochore organization (GO:0051383)3.01379691
111RNA catabolic process (GO:0006401)3.00928541
112establishment of chromosome localization (GO:0051303)3.00830628
113regulation of translational termination (GO:0006449)3.00138775
114regulation of chromosome segregation (GO:0051983)2.96597581
115pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95996321
116sulfur amino acid biosynthetic process (GO:0000097)2.95010285
117base-excision repair (GO:0006284)2.94252974
118protein localization to chromosome (GO:0034502)2.93933287
119negative regulation of chromosome segregation (GO:0051985)2.93698170
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.92732902
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92732902
122translation (GO:0006412)2.91462290
123UTP biosynthetic process (GO:0006228)2.90239402
124rRNA transcription (GO:0009303)2.90011193
125pteridine-containing compound metabolic process (GO:0042558)2.89584380
126chromatin assembly or disassembly (GO:0006333)2.89079340
127rRNA processing (GO:0006364)2.89045095
128telomere maintenance (GO:0000723)2.88263752
129polyamine biosynthetic process (GO:0006596)2.87785346
130telomere organization (GO:0032200)2.87646540
131nuclear pore complex assembly (GO:0051292)2.86409164
132GDP-mannose metabolic process (GO:0019673)2.85712883
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85599487
134negative regulation of sister chromatid segregation (GO:0033046)2.85599487
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.85599487
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85599487
137mitochondrial DNA metabolic process (GO:0032042)2.85566305
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85072682
139translesion synthesis (GO:0019985)2.84607527
140mitotic G1 DNA damage checkpoint (GO:0031571)2.84330778
141regulation of mitotic spindle organization (GO:0060236)2.84087499
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81640230
143protein retention in ER lumen (GO:0006621)2.81106364
144peptidyl-arginine omega-N-methylation (GO:0035247)2.80545934
145RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80095310
146mRNA splicing, via spliceosome (GO:0000398)2.80095310
147response to vitamin A (GO:0033189)2.80027297
148postreplication repair (GO:0006301)2.79746373
149spindle assembly checkpoint (GO:0071173)2.79340123
150peptidyl-arginine modification (GO:0018195)2.79272927
151rRNA metabolic process (GO:0016072)2.79134929
152pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.79063513
153desmosome organization (GO:0002934)2.78960560
154pre-miRNA processing (GO:0031054)2.78910885
155negative regulation of catenin import into nucleus (GO:0035414)2.78313595
156alpha-amino acid biosynthetic process (GO:1901607)2.78018317
157folic acid transport (GO:0015884)2.77839581
158negative regulation of DNA-templated transcription, elongation (GO:0032785)2.76982459
159mRNA splice site selection (GO:0006376)2.76108471
1604-hydroxyproline metabolic process (GO:0019471)2.74423613
161dosage compensation (GO:0007549)2.74330315
162protein insertion into membrane (GO:0051205)2.74084729
163histone H4-K8 acetylation (GO:0043982)2.70934211
164histone H4-K5 acetylation (GO:0043981)2.70934211
165transcription from mitochondrial promoter (GO:0006390)2.69291200
166ATP-dependent chromatin remodeling (GO:0043044)2.66974378
167pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.65676766
168mitotic nuclear envelope reassembly (GO:0007084)2.64093710
169nuclear envelope reassembly (GO:0031468)2.64093710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.08252440
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.54787089
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93888835
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.77185681
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.70217145
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25009597
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94851526
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81018466
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47477640
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42351389
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.28137099
12MYC_22102868_ChIP-Seq_BL_Human2.27686313
13* XRN2_22483619_ChIP-Seq_HELA_Human2.26733579
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.22815047
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18655692
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.17074434
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11001390
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10768031
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03981958
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99035802
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94380237
22LXR_22292898_ChIP-Seq_THP-1_Human1.91996721
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.89975990
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89279468
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85168984
26AR_21909140_ChIP-Seq_LNCAP_Human1.84334133
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82904541
28* E2F1_21310950_ChIP-Seq_MCF-7_Human1.82637319
29CIITA_25753668_ChIP-Seq_RAJI_Human1.76964317
30VDR_21846776_ChIP-Seq_THP-1_Human1.74429413
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74185703
32* VDR_23849224_ChIP-Seq_CD4+_Human1.71450123
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68019701
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67417534
35P68_20966046_ChIP-Seq_HELA_Human1.65821442
36FOXP3_21729870_ChIP-Seq_TREG_Human1.62249451
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62125962
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60581845
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59925480
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59212555
41GABP_19822575_ChIP-Seq_HepG2_Human1.58785482
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.58386268
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58040545
44DCP1A_22483619_ChIP-Seq_HELA_Human1.57001627
45TTF2_22483619_ChIP-Seq_HELA_Human1.56810691
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54383203
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53982380
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53423479
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52993909
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48836652
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48831473
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46425593
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43590543
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41210619
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40153881
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38668680
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37739917
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36472763
59KDM5A_27292631_Chip-Seq_BREAST_Human1.36055132
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35601564
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32220388
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29379857
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26537846
64TBX5_21415370_ChIP-Seq_HL-1_Mouse1.24893627
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24447986
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.24346826
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24074334
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.23954319
69RACK7_27058665_Chip-Seq_MCF-7_Human1.21674132
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20605492
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19800252
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19545429
73BCOR_27268052_Chip-Seq_Bcells_Human1.19504913
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18679929
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18317632
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17692983
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16888264
78ZNF263_19887448_ChIP-Seq_K562_Human1.16609272
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16591491
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16046488
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15732171
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15545317
83BCL6_27268052_Chip-Seq_Bcells_Human1.15180513
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.14531138
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13984347
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13517553
87* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12689847
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12517301
89* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11677910
90TFEB_21752829_ChIP-Seq_HELA_Human1.11648205
91* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10921287
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.10615311
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09729737
94FOXP1_21924763_ChIP-Seq_HESCs_Human1.08947261
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08407668
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.06951781
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06157655
98ELK1_19687146_ChIP-ChIP_HELA_Human1.05963766
99SMC4_20622854_ChIP-Seq_HELA_Human1.05569138
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05465269
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05370128
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03945982
103PHF8_20622854_ChIP-Seq_HELA_Human1.03273889
104* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02602296
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02517113
106NCOR1_26117541_ChIP-Seq_K562_Human1.02215402
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00704737
108* CTCF_26484167_Chip-Seq_Bcells_Mouse1.00622185
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00195835
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99657373
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.99480065
112MAF_26560356_Chip-Seq_TH1_Human0.99171210
113UTX_26944678_Chip-Seq_JUKART_Human0.98233137
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97193419
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95678468
116TP63_17297297_ChIP-ChIP_HaCaT_Human0.95211973
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95020446
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92790768
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89883058
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89872164
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.89326640
122SPI1_23547873_ChIP-Seq_NB4_Human0.89075518
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88643282
124TCF7_22412390_ChIP-Seq_EML_Mouse0.87163856
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.86934399
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86932629
127ATF3_27146783_Chip-Seq_COLON_Human0.85816137
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85652287
129* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84230968
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84123771
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82547281
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82477586
133MAF_26560356_Chip-Seq_TH2_Human0.82274623

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.68214473
2MP0003111_abnormal_nucleus_morphology4.34556321
3MP0010094_abnormal_chromosome_stability4.26667707
4MP0004957_abnormal_blastocyst_morpholog4.08019130
5MP0003077_abnormal_cell_cycle3.78500610
6MP0008995_early_reproductive_senescence3.30007283
7MP0001661_extended_life_span3.29488129
8MP0000013_abnormal_adipose_tissue3.26442536
9MP0005670_abnormal_white_adipose3.18574133
10MP0004185_abnormal_adipocyte_glucose3.05642666
11MP0008057_abnormal_DNA_replication2.91767533
12MP0008007_abnormal_cellular_replicative2.88640392
13MP0010352_gastrointestinal_tract_polyps2.75664616
14MP0005360_urolithiasis2.65826296
15MP0000003_abnormal_adipose_tissue2.47635817
16MP0002396_abnormal_hematopoietic_system2.43747424
17MP0008058_abnormal_DNA_repair2.33027171
18MP0005451_abnormal_body_composition2.32477154
19MP0008932_abnormal_embryonic_tissue2.31196881
20MP0001730_embryonic_growth_arrest2.30035101
21MP0000350_abnormal_cell_proliferation2.26552552
22MP0010307_abnormal_tumor_latency2.07069724
23MP0003183_abnormal_peptide_metabolism2.06991949
24MP0003705_abnormal_hypodermis_morpholog1.94994204
25MP0010030_abnormal_orbit_morphology1.94544866
26MP0000490_abnormal_crypts_of1.90356914
27MP0003123_paternal_imprinting1.86854454
28MP0004808_abnormal_hematopoietic_stem1.82812782
29MP0008260_abnormal_autophagy1.80912971
30MP0001697_abnormal_embryo_size1.73653255
31MP0002080_prenatal_lethality1.67583403
32MP0005380_embryogenesis_phenotype1.62996172
33MP0001672_abnormal_embryogenesis/_devel1.62996172
34MP0002019_abnormal_tumor_incidence1.61887923
35MP0005076_abnormal_cell_differentiation1.59726744
36MP0003786_premature_aging1.56203442
37MP0003763_abnormal_thymus_physiology1.54354861
38MP0000747_muscle_weakness1.53910879
39MP0003984_embryonic_growth_retardation1.49605753
40MP0004197_abnormal_fetal_growth/weight/1.48803179
41MP0002088_abnormal_embryonic_growth/wei1.47536746
42MP0000313_abnormal_cell_death1.46913848
43MP0002086_abnormal_extraembryonic_tissu1.46407654
44MP0000537_abnormal_urethra_morphology1.45655410
45MP0002085_abnormal_embryonic_tissue1.45243579
46MP0009278_abnormal_bone_marrow1.44442765
47MP0005397_hematopoietic_system_phenotyp1.40504892
48MP0001545_abnormal_hematopoietic_system1.40504892
49MP0002084_abnormal_developmental_patter1.40321100
50MP0009333_abnormal_splenocyte_physiolog1.34948582
51* MP0000703_abnormal_thymus_morphology1.34262459
52MP0000678_abnormal_parathyroid_gland1.32397833
53* MP0002398_abnormal_bone_marrow1.31193062
54MP0005646_abnormal_pituitary_gland1.30389889
55* MP0002722_abnormal_immune_system1.29818829
56MP0005023_abnormal_wound_healing1.29219219
57MP0003566_abnormal_cell_adhesion1.27706855
58MP0006054_spinal_hemorrhage1.24802566
59* MP0000689_abnormal_spleen_morphology1.20115709
60MP0004147_increased_porphyrin_level1.19890204
61MP0002736_abnormal_nociception_after1.17038351
62MP0003567_abnormal_fetal_cardiomyocyte1.16337488
63MP0000858_altered_metastatic_potential1.15244157
64MP0001764_abnormal_homeostasis1.14556940
65MP0006035_abnormal_mitochondrial_morpho1.14076699
66MP0009053_abnormal_anal_canal1.10555106
67MP0000358_abnormal_cell_content/1.08742480
68MP0005666_abnormal_adipose_tissue1.08172401
69MP0002249_abnormal_larynx_morphology1.08012480
70MP0003806_abnormal_nucleotide_metabolis1.06858167
71MP0005375_adipose_tissue_phenotype1.04840152
72* MP0002429_abnormal_blood_cell1.03387353
73MP0009840_abnormal_foam_cell1.02303925
74MP0002970_abnormal_white_adipose1.02066391
75MP0000685_abnormal_immune_system1.01984434
76MP0009379_abnormal_foot_pigmentation1.01055603
77MP0002095_abnormal_skin_pigmentation1.00701853
78MP0002269_muscular_atrophy0.96322149
79MP0001929_abnormal_gametogenesis0.96225328
80MP0006036_abnormal_mitochondrial_physio0.96099787
81MP0005171_absent_coat_pigmentation0.95911661
82MP0000750_abnormal_muscle_regeneration0.95642716
83MP0001849_ear_inflammation0.94686639
84MP0002075_abnormal_coat/hair_pigmentati0.94065435
85MP0005501_abnormal_skin_physiology0.92614955
86MP0001270_distended_abdomen0.92195164
87MP0002111_abnormal_tail_morphology0.88837245
88MP0001293_anophthalmia0.86536469
89MP0003315_abnormal_perineum_morphology0.85853597
90* MP0000716_abnormal_immune_system0.85143287
91MP0000653_abnormal_sex_gland0.84946921
92MP0009672_abnormal_birth_weight0.84705621
93MP0003698_abnormal_male_reproductive0.84066572
94MP0003656_abnormal_erythrocyte_physiolo0.83679947
95MP0003119_abnormal_digestive_system0.83648495
96MP0002132_abnormal_respiratory_system0.83125662
97MP0000428_abnormal_craniofacial_morphol0.82011248
98MP0005075_abnormal_melanosome_morpholog0.80037895
99MP0000477_abnormal_intestine_morphology0.80012665
100MP0001346_abnormal_lacrimal_gland0.79731486
101MP0003172_abnormal_lysosome_physiology0.79587925
102MP0002938_white_spotting0.79575472
103MP0000015_abnormal_ear_pigmentation0.79136690
104MP0002405_respiratory_system_inflammati0.78228341
105MP0001800_abnormal_humoral_immune0.78129020
106MP0005384_cellular_phenotype0.77878886
107MP0005621_abnormal_cell_physiology0.77251255
108MP0000566_synostosis0.75902664
109MP0001873_stomach_inflammation0.75080472
110MP0002653_abnormal_ependyma_morphology0.74075664
111MP0001915_intracranial_hemorrhage0.73987496
112MP0002161_abnormal_fertility/fecundity0.73438526
113MP0000465_gastrointestinal_hemorrhage0.72450909
114MP0008770_decreased_survivor_rate0.72355359
115MP0002877_abnormal_melanocyte_morpholog0.72137642
116MP0000733_abnormal_muscle_development0.70655582
117MP0003718_maternal_effect0.70445378
118MP0008877_abnormal_DNA_methylation0.70288891
119MP0009931_abnormal_skin_appearance0.69597750
120MP0000751_myopathy0.69415580
121MP0002420_abnormal_adaptive_immunity0.69079042
122MP0005058_abnormal_lysosome_morphology0.68845564
123MP0001819_abnormal_immune_cell0.67579618
124MP0002452_abnormal_antigen_presenting0.67111782
125MP0000759_abnormal_skeletal_muscle0.66671234
126MP0010155_abnormal_intestine_physiology0.65757785
127MP0005464_abnormal_platelet_physiology0.65652593
128MP0003115_abnormal_respiratory_system0.65396827
129MP0002210_abnormal_sex_determination0.65313613
130MP0004947_skin_inflammation0.64988705
131MP0010234_abnormal_vibrissa_follicle0.64776766
132MP0001145_abnormal_male_reproductive0.64741827
133MP0004233_abnormal_muscle_weight0.64351538
134MP0000681_abnormal_thyroid_gland0.64137421
135MP0002092_abnormal_eye_morphology0.64116373
136MP0001186_pigmentation_phenotype0.63894035
137MP0003699_abnormal_female_reproductive0.63155006
138MP0000371_diluted_coat_color0.62878930
139MP0000598_abnormal_liver_morphology0.62125802
140MP0001216_abnormal_epidermal_layer0.62099012
141MP0003448_altered_tumor_morphology0.60339066
142MP0003186_abnormal_redox_activity0.60290367
143MP0003436_decreased_susceptibility_to0.58855663
144MP0003221_abnormal_cardiomyocyte_apopto0.58793497
145MP0001243_abnormal_dermal_layer0.58624327
146MP0005174_abnormal_tail_pigmentation0.58076441
147MP0002089_abnormal_postnatal_growth/wei0.58017816

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.80558940
2Hyperalaninemia (HP:0003348)5.80558940
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.80558940
4Reticulocytopenia (HP:0001896)4.89962581
5Abnormality of cells of the erythroid lineage (HP:0012130)4.42320189
6Abnormal number of erythroid precursors (HP:0012131)4.17575306
7Abnormality of the fetal cardiovascular system (HP:0010948)3.56794821
8Abnormal umbilical cord blood vessels (HP:0011403)3.56794821
9Single umbilical artery (HP:0001195)3.56794821
10Selective tooth agenesis (HP:0001592)3.53814263
11Macrocytic anemia (HP:0001972)3.37791966
12Myopathic facies (HP:0002058)3.35864619
13Colon cancer (HP:0003003)3.31406747
14Biconcave vertebral bodies (HP:0004586)3.29455309
15Birth length less than 3rd percentile (HP:0003561)3.28312467
16Fatigue (HP:0012378)3.27015416
17Constricted visual fields (HP:0001133)3.22909782
18Ependymoma (HP:0002888)3.15966434
19White forelock (HP:0002211)3.14817594
20Ragged-red muscle fibers (HP:0003200)3.05180131
21Pallor (HP:0000980)3.02993261
22Abnormality of the umbilical cord (HP:0010881)3.02466455
23Microvesicular hepatic steatosis (HP:0001414)2.99189810
24Oral leukoplakia (HP:0002745)2.97315958
25Broad distal phalanx of finger (HP:0009836)2.93664391
26Rhabdomyosarcoma (HP:0002859)2.88123708
27Esophageal varix (HP:0002040)2.88103113
28Thrombocytosis (HP:0001894)2.87468895
29Heterochromia iridis (HP:0001100)2.84377928
30Medulloblastoma (HP:0002885)2.83262500
31Basal cell carcinoma (HP:0002671)2.80686173
32Hyperacusis (HP:0010780)2.79945920
33Abnormality of reticulocytes (HP:0004312)2.77566339
34Abnormality of homocysteine metabolism (HP:0010919)2.75157900
35Homocystinuria (HP:0002156)2.75157900
36Spontaneous hematomas (HP:0007420)2.72151974
37Aplastic anemia (HP:0001915)2.71776652
38Trismus (HP:0000211)2.71666100
39Abnormality of glycolysis (HP:0004366)2.71284281
40Abnormality of cochlea (HP:0000375)2.69675449
41Breast hypoplasia (HP:0003187)2.68805619
42Patchy hypopigmentation of hair (HP:0011365)2.67777796
43Patellar aplasia (HP:0006443)2.66356149
44Multiple enchondromatosis (HP:0005701)2.63812209
45Increased nuchal translucency (HP:0010880)2.60477317
46Abnormal gallbladder physiology (HP:0012438)2.59684659
47Cholecystitis (HP:0001082)2.59684659
48Aplasia/Hypoplasia of the patella (HP:0006498)2.57627814
49Agnosia (HP:0010524)2.54098428
50Myocardial infarction (HP:0001658)2.51823654
51Absent thumb (HP:0009777)2.49372370
52Duplicated collecting system (HP:0000081)2.47040912
53Neoplasm of the pancreas (HP:0002894)2.45644091
54Increased serum pyruvate (HP:0003542)2.44767633
55Metaphyseal cupping (HP:0003021)2.41322784
5611 pairs of ribs (HP:0000878)2.41310511
57Rough bone trabeculation (HP:0100670)2.40148745
58Progressive external ophthalmoplegia (HP:0000590)2.37190006
59Hypertensive crisis (HP:0100735)2.36532651
60Degeneration of anterior horn cells (HP:0002398)2.33430166
61Abnormality of the anterior horn cell (HP:0006802)2.33430166
62Morphological abnormality of the inner ear (HP:0011390)2.32344978
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.31764539
64Absent epiphyses (HP:0010577)2.31764539
65Carpal bone hypoplasia (HP:0001498)2.28678560
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28613787
67Abnormal number of incisors (HP:0011064)2.27771040
68High pitched voice (HP:0001620)2.27676131
69Reduced subcutaneous adipose tissue (HP:0003758)2.27646201
70Arteriovenous malformation (HP:0100026)2.27193961
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26630882
72Spastic diplegia (HP:0001264)2.26118373
73Adenoma sebaceum (HP:0009720)2.24743907
74Angiofibromas (HP:0010615)2.24743907
75Cortical visual impairment (HP:0100704)2.24566558
76Proximal placement of thumb (HP:0009623)2.23976854
77Thin ribs (HP:0000883)2.23718533
78Myelodysplasia (HP:0002863)2.22314968
79Abnormality of the carotid arteries (HP:0005344)2.22235430
80Distal lower limb amyotrophy (HP:0008944)2.21304898
81Abnormality of the calcaneus (HP:0008364)2.20962850
82Anorexia (HP:0002039)2.20719706
83Meckel diverticulum (HP:0002245)2.19870465
84Deviation of the thumb (HP:0009603)2.18683941
85Visceral angiomatosis (HP:0100761)2.17146221
86Gastrointestinal dysmotility (HP:0002579)2.16708839
87Poor speech (HP:0002465)2.14741583
88Microretrognathia (HP:0000308)2.13128237
89Chromsome breakage (HP:0040012)2.12508929
90Neoplasm of striated muscle (HP:0009728)2.11641411
91Abnormality of the ileum (HP:0001549)2.08392966
92Renal duplication (HP:0000075)2.08194522
93Hypopigmentation of the fundus (HP:0007894)2.07978784
94Missing ribs (HP:0000921)2.07857559
95Decreased subcutaneous fat (HP:0001002)2.07793633
96Abnormality of subcutaneous fat tissue (HP:0001001)2.06845141
97Flattened epiphyses (HP:0003071)2.06544504
98Hypergonadotropic hypogonadism (HP:0000815)2.05942663
99Duodenal stenosis (HP:0100867)2.05847880
100Small intestinal stenosis (HP:0012848)2.05847880
101Duplication of thumb phalanx (HP:0009942)2.04864194
102Abnormality of the renal collecting system (HP:0004742)2.03650439
103Disproportionate tall stature (HP:0001519)2.03424374
104Atresia of the external auditory canal (HP:0000413)2.02992823
105Abnormality of the preputium (HP:0100587)2.02746896
106Poikiloderma (HP:0001029)2.01413257
107Ankle clonus (HP:0011448)2.01286861
108Ankle contracture (HP:0006466)2.01227955
109Abnormality of chromosome stability (HP:0003220)2.01192043
110Squamous cell carcinoma (HP:0002860)2.00715408
111Slender long bone (HP:0003100)2.00409034
112Abnormality of DNA repair (HP:0003254)1.99176512
113Tracheoesophageal fistula (HP:0002575)1.97182135
114Difficulty climbing stairs (HP:0003551)1.95547459
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94797074
116Congenital sensorineural hearing impairment (HP:0008527)1.94137038
117Impulsivity (HP:0100710)1.92331266
118Absent radius (HP:0003974)1.92116964
119Astrocytoma (HP:0009592)1.92039211
120Abnormality of the astrocytes (HP:0100707)1.92039211
121Oligomenorrhea (HP:0000876)1.91694872
122Hemangiomatosis (HP:0007461)1.91386468
123Premature graying of hair (HP:0002216)1.91017946
124Ureteral duplication (HP:0000073)1.90848804
125Neoplasm of the colon (HP:0100273)1.90155704
126Increased density of long bones (HP:0006392)1.89592948
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.89365849
128Thoracic kyphosis (HP:0002942)1.88622448
129Cafe-au-lait spot (HP:0000957)1.87474720
130Bone marrow hypocellularity (HP:0005528)1.87185520
131IgM deficiency (HP:0002850)1.85616363
132Personality changes (HP:0000751)1.85562977
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84808282
134Diaphragmatic weakness (HP:0009113)1.84769250
135Ileus (HP:0002595)1.83939871
136Elevated alkaline phosphatase (HP:0003155)1.82348161
137Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82328920
138Short 4th metacarpal (HP:0010044)1.82328920
139Insulin resistance (HP:0000855)1.82057030
140Long palpebral fissure (HP:0000637)1.81306682
141Horseshoe kidney (HP:0000085)1.80858822
142Increased serum lactate (HP:0002151)1.80094112
143Glossoptosis (HP:0000162)1.79989949
144Conjunctival telangiectasia (HP:0000524)1.79936495
145Insomnia (HP:0100785)1.79715316
146Progressive microcephaly (HP:0000253)1.78740131
147Abnormality of the thoracic spine (HP:0100711)1.78433644
148Protrusio acetabuli (HP:0003179)1.78386758
149Absent forearm bone (HP:0003953)1.77213271
150Aplasia involving forearm bones (HP:0009822)1.77213271
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.77103907
152Abnormality of serum amino acid levels (HP:0003112)1.75402658
153Optic nerve coloboma (HP:0000588)1.74962413
154Distal upper limb amyotrophy (HP:0007149)1.74226130
155Upper limb amyotrophy (HP:0009129)1.74226130
156Progressive muscle weakness (HP:0003323)1.73161501
157Premature ovarian failure (HP:0008209)1.73045506
158Petechiae (HP:0000967)1.72868879
159Overlapping toe (HP:0001845)1.72356916
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72292097
161Cerebral hypomyelination (HP:0006808)1.71654310
162Intestinal polyp (HP:0005266)1.71529213
163Polygenic inheritance (HP:0010982)1.71434598
164Lymphoma (HP:0002665)1.69692468
165Brittle hair (HP:0002299)1.69499549
166Abnormality of pyrimidine metabolism (HP:0004353)1.69115192
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68891826
168Mesangial abnormality (HP:0001966)1.68856566
169Cellular immunodeficiency (HP:0005374)1.68138179
170Cerebral aneurysm (HP:0004944)1.66865360
171Megaloblastic anemia (HP:0001889)1.66335827
172Papilloma (HP:0012740)1.65776083
173Verrucae (HP:0200043)1.65776083
174Amaurosis fugax (HP:0100576)1.65748329
175Biliary tract neoplasm (HP:0100574)1.65385499
176Abnormality of the duodenum (HP:0002246)1.65193226
177Intestinal polyposis (HP:0200008)1.65171533
178Prominent nose (HP:0000448)1.65055993
179Ovarian neoplasm (HP:0100615)1.64938365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.62862000
2EEF2K3.52882174
3WEE13.52686886
4CDC73.42233940
5SMG13.24693046
6NEK22.95987513
7MAP3K102.74351480
8TLK12.72102393
9PKN22.58591504
10NEK12.40370550
11TRIB32.31341900
12IRAK32.16223914
13PRPF4B2.15684471
14NME22.09885992
15TESK22.05714030
16RPS6KB22.04559418
17EIF2AK11.83096153
18ICK1.77248636
19VRK21.75255327
20TTK1.74485505
21TSSK61.71458425
22STK101.69833788
23PLK11.66602875
24SCYL21.66453413
25CDK91.66220284
26FGR1.64338847
27MAP4K11.61919561
28CDK71.51819453
29AURKB1.50411893
30MAP3K81.48448425
31PAK41.48104001
32LRRK21.47607329
33RPS6KA41.47591708
34PASK1.46349830
35CDK41.45093616
36BRSK21.41430221
37JAK31.39436786
38EPHA21.38348236
39ATR1.35225343
40CDK121.32711359
41BCKDK1.29098318
42SRPK11.28390807
43TAOK21.22515925
44BRSK11.22218123
45AURKA1.21549089
46SIK21.21474090
47TGFBR11.21267485
48STK161.21235546
49VRK11.14500678
50FLT31.12640121
51STK41.09936089
52LMTK21.09710425
53ARAF1.08836384
54MAP3K111.07458266
55TTN1.07078805
56ACVR1B1.02904885
57CCNB11.01337412
58DYRK30.98784124
59GRK60.97609800
60MAP2K30.97107683
61CHEK20.95132398
62MAPKAPK30.93778130
63TESK10.92256783
64CHEK10.91181427
65SIK10.89181525
66IRAK20.83321688
67PIM10.82847283
68PRKD30.81011908
69BRAF0.80226774
70KDR0.80054247
71IRAK40.79104174
72PLK30.75984795
73ILK0.74305353
74NTRK20.73627899
75BMX0.72989823
76PAK10.71528230
77ZAP700.71369480
78ALK0.69517609
79CDK20.68627380
80BTK0.68241357
81MKNK10.67679249
82TBK10.66745725
83CDK60.66554828
84CSNK1G30.66037693
85PLK40.63993840
86CSF1R0.61509447
87CAMKK10.61212348
88CDK190.60969931
89NME10.60292326
90RIPK10.59247022
91ATM0.58411973
92PAK60.58034327
93PIM20.57113303
94EIF2AK30.56562871
95TYK20.56334483
96AKT20.55154166
97MAP3K60.54537229
98PTK60.53606566
99CLK10.51111202
100NEK90.50945686
101MAPK110.48689590
102LIMK10.48521081
103CSNK2A20.48371437
104CDK150.48296544
105PRKCI0.47183181
106MST1R0.46351688
107BLK0.45983821
108MTOR0.45504124
109UHMK10.44801894
110FGFR40.44234543
111MAP3K30.43778294
112CDK180.43226392
113CDK10.42859747
114KSR20.42776601
115MAP2K20.42587932
116CSNK2A10.41428518
117CSNK1A1L0.39941712
118CDK140.39258712
119ERN10.38910178
120PAK20.37232183
121RPS6KC10.35667220
122RPS6KL10.35667220
123DAPK30.35142619
124MELK0.34555544
125CDK80.33499850
126RPS6KA60.30884152
127RAF10.30813566
128SGK2230.30579934
129RPS6KA10.29557049
130ZAK0.29396886
131KIT0.27912543
132DAPK10.27298116
133PDGFRA0.26364870
134CDK11A0.25448579
135RPS6KA50.24532194

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29857760
2Mismatch repair_Homo sapiens_hsa034304.28981380
3Ribosome_Homo sapiens_hsa030103.87921094
4Base excision repair_Homo sapiens_hsa034103.27810163
5One carbon pool by folate_Homo sapiens_hsa006703.09615737
6Spliceosome_Homo sapiens_hsa030403.08695317
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73217323
8Nucleotide excision repair_Homo sapiens_hsa034202.72885500
9RNA transport_Homo sapiens_hsa030132.69933938
10Homologous recombination_Homo sapiens_hsa034402.64823736
11Cell cycle_Homo sapiens_hsa041102.55319765
12Proteasome_Homo sapiens_hsa030502.53264728
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53226938
14Pyrimidine metabolism_Homo sapiens_hsa002401.99964589
15RNA polymerase_Homo sapiens_hsa030201.94633732
16Other glycan degradation_Homo sapiens_hsa005111.92996557
17Arginine biosynthesis_Homo sapiens_hsa002201.81803261
18Non-homologous end-joining_Homo sapiens_hsa034501.71156483
19Fanconi anemia pathway_Homo sapiens_hsa034601.67611408
20Systemic lupus erythematosus_Homo sapiens_hsa053221.60130574
21Vibrio cholerae infection_Homo sapiens_hsa051101.52743941
22p53 signaling pathway_Homo sapiens_hsa041151.50169375
23mRNA surveillance pathway_Homo sapiens_hsa030151.46087659
24Selenocompound metabolism_Homo sapiens_hsa004501.42153512
25Biosynthesis of amino acids_Homo sapiens_hsa012301.33826777
26Pentose phosphate pathway_Homo sapiens_hsa000301.25729048
27RNA degradation_Homo sapiens_hsa030181.24953523
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.22737328
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21670037
30Collecting duct acid secretion_Homo sapiens_hsa049661.18972637
31Sulfur metabolism_Homo sapiens_hsa009201.18102577
32Viral carcinogenesis_Homo sapiens_hsa052031.15931197
33Sulfur relay system_Homo sapiens_hsa041221.14814971
34Antigen processing and presentation_Homo sapiens_hsa046121.11431590
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09581552
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06033121
37Epstein-Barr virus infection_Homo sapiens_hsa051691.04965393
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02091720
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01478602
40Synaptic vesicle cycle_Homo sapiens_hsa047210.98865142
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98532217
42Carbon metabolism_Homo sapiens_hsa012000.97979282
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.95419603
44Fructose and mannose metabolism_Homo sapiens_hsa000510.93719742
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93688469
46HTLV-I infection_Homo sapiens_hsa051660.92799683
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92503093
48Small cell lung cancer_Homo sapiens_hsa052220.89003173
49Primary immunodeficiency_Homo sapiens_hsa053400.88657108
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.88434180
51Oocyte meiosis_Homo sapiens_hsa041140.88422639
52Herpes simplex infection_Homo sapiens_hsa051680.83883610
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82029112
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79387314
55Bladder cancer_Homo sapiens_hsa052190.78472621
56Thyroid cancer_Homo sapiens_hsa052160.78226164
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78028542
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77449740
59Galactose metabolism_Homo sapiens_hsa000520.77368034
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.77238906
61Legionellosis_Homo sapiens_hsa051340.75746290
62Purine metabolism_Homo sapiens_hsa002300.75454352
63Vitamin B6 metabolism_Homo sapiens_hsa007500.75445160
64Basal transcription factors_Homo sapiens_hsa030220.75295301
65Chronic myeloid leukemia_Homo sapiens_hsa052200.73169953
66Apoptosis_Homo sapiens_hsa042100.71261220
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71115948
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68432769
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62376684
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61212009
71MicroRNAs in cancer_Homo sapiens_hsa052060.60009480
72Notch signaling pathway_Homo sapiens_hsa043300.56177540
73Alcoholism_Homo sapiens_hsa050340.55514313
74Regulation of autophagy_Homo sapiens_hsa041400.54710709
75Arginine and proline metabolism_Homo sapiens_hsa003300.53401015
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52681936
77Folate biosynthesis_Homo sapiens_hsa007900.52190898
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48379245
79HIF-1 signaling pathway_Homo sapiens_hsa040660.47966703
80Acute myeloid leukemia_Homo sapiens_hsa052210.47311621
81Shigellosis_Homo sapiens_hsa051310.46639550
82Hepatitis B_Homo sapiens_hsa051610.46421489
83AMPK signaling pathway_Homo sapiens_hsa041520.45619145
84N-Glycan biosynthesis_Homo sapiens_hsa005100.45376337
85Glutathione metabolism_Homo sapiens_hsa004800.45282804
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45160846
87Colorectal cancer_Homo sapiens_hsa052100.44704915
88Non-small cell lung cancer_Homo sapiens_hsa052230.43000928
89Prion diseases_Homo sapiens_hsa050200.42107829
90Measles_Homo sapiens_hsa051620.40387034
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39314336
92Basal cell carcinoma_Homo sapiens_hsa052170.38953277
93Hippo signaling pathway_Homo sapiens_hsa043900.37258057
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35932127
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35416062
96mTOR signaling pathway_Homo sapiens_hsa041500.34682754
97Phenylalanine metabolism_Homo sapiens_hsa003600.34613379
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.33044540
99Metabolic pathways_Homo sapiens_hsa011000.32918438
100Viral myocarditis_Homo sapiens_hsa054160.32731910
101B cell receptor signaling pathway_Homo sapiens_hsa046620.32654746
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31548126
103Glioma_Homo sapiens_hsa052140.28595308
104Lysine degradation_Homo sapiens_hsa003100.28557142
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.28340752
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.28337295
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.25480938
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25459203
109Renin-angiotensin system_Homo sapiens_hsa046140.24984736
110Fatty acid elongation_Homo sapiens_hsa000620.24725239
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24361074
112Proteoglycans in cancer_Homo sapiens_hsa052050.24347332
113Pathways in cancer_Homo sapiens_hsa052000.23909802
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23625902
115Morphine addiction_Homo sapiens_hsa050320.23250599
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22301038
117Influenza A_Homo sapiens_hsa051640.22247016
118GABAergic synapse_Homo sapiens_hsa047270.21766454
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18838696
120Pancreatic cancer_Homo sapiens_hsa052120.16768699
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.16538061
122VEGF signaling pathway_Homo sapiens_hsa043700.15808356
123Huntingtons disease_Homo sapiens_hsa050160.15446732
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14702561
125Leishmaniasis_Homo sapiens_hsa051400.14442576
126Oxidative phosphorylation_Homo sapiens_hsa001900.14199338
127Toxoplasmosis_Homo sapiens_hsa051450.14136200
128Hematopoietic cell lineage_Homo sapiens_hsa046400.13640906
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12637901
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11650568
131Adherens junction_Homo sapiens_hsa045200.11341119

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