NCBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.01959172
2nuclear pore complex assembly (GO:0051292)5.00489745
3nuclear pore organization (GO:0006999)4.97170898
4protein localization to kinetochore (GO:0034501)4.57095419
5mitotic nuclear envelope disassembly (GO:0007077)4.44365693
6protein localization to chromosome, centromeric region (GO:0071459)4.36317806
7double-strand break repair via nonhomologous end joining (GO:0006303)4.33985158
8non-recombinational repair (GO:0000726)4.33985158
9DNA replication-dependent nucleosome organization (GO:0034723)4.30798048
10DNA replication-dependent nucleosome assembly (GO:0006335)4.30798048
11DNA strand elongation involved in DNA replication (GO:0006271)4.24643125
12nuclear envelope disassembly (GO:0051081)4.19014279
13membrane disassembly (GO:0030397)4.19014279
14DNA replication initiation (GO:0006270)4.17821682
15nucleobase biosynthetic process (GO:0046112)4.08282209
16meiotic chromosome segregation (GO:0045132)4.08100379
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04182255
18mitotic metaphase plate congression (GO:0007080)3.98982931
19DNA strand elongation (GO:0022616)3.98469026
20folic acid-containing compound biosynthetic process (GO:0009396)3.97812068
21mitotic sister chromatid cohesion (GO:0007064)3.95508735
22mitotic chromosome condensation (GO:0007076)3.88004773
23formation of translation preinitiation complex (GO:0001731)3.86680943
24pore complex assembly (GO:0046931)3.86557168
25purine nucleobase biosynthetic process (GO:0009113)3.82982737
26mitotic sister chromatid segregation (GO:0000070)3.80212826
27positive regulation of chromosome segregation (GO:0051984)3.77694964
28IMP biosynthetic process (GO:0006188)3.73490496
29sister chromatid segregation (GO:0000819)3.73248597
30translesion synthesis (GO:0019985)3.63907155
31regulation of spindle organization (GO:0090224)3.63255058
32establishment of integrated proviral latency (GO:0075713)3.60192779
33DNA duplex unwinding (GO:0032508)3.59484471
34DNA replication checkpoint (GO:0000076)3.57049816
35DNA geometric change (GO:0032392)3.56402912
36telomere maintenance via semi-conservative replication (GO:0032201)3.51673960
37metaphase plate congression (GO:0051310)3.49453038
38regulation of chromosome segregation (GO:0051983)3.43558988
39ribosome assembly (GO:0042255)3.41927120
40regulation of histone H3-K9 methylation (GO:0051570)3.40874347
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.40396517
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40396517
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40396517
44regulation of centriole replication (GO:0046599)3.38608886
45nuclear envelope organization (GO:0006998)3.36851486
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33810271
47regulation of centrosome duplication (GO:0010824)3.33770495
48regulation of translational fidelity (GO:0006450)3.32813067
49mitotic recombination (GO:0006312)3.31239747
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29511934
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.29511934
52regulation of centrosome cycle (GO:0046605)3.29412928
53binding of sperm to zona pellucida (GO:0007339)3.27389168
54chromosome condensation (GO:0030261)3.26951350
55heterochromatin organization (GO:0070828)3.26914288
56regulation of RNA export from nucleus (GO:0046831)3.25802427
57telomere maintenance via recombination (GO:0000722)3.25415076
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23835384
59maturation of SSU-rRNA (GO:0030490)3.23831876
60histone exchange (GO:0043486)3.22337427
61protein localization to chromosome (GO:0034502)3.22262516
62IMP metabolic process (GO:0046040)3.20868918
63postreplication repair (GO:0006301)3.20700387
64DNA replication-independent nucleosome assembly (GO:0006336)3.19992806
65DNA replication-independent nucleosome organization (GO:0034724)3.19992806
66regulation of DNA damage checkpoint (GO:2000001)3.19602197
67regulation of DNA endoreduplication (GO:0032875)3.19158278
68establishment of chromosome localization (GO:0051303)3.18034131
69DNA synthesis involved in DNA repair (GO:0000731)3.17871634
70pre-miRNA processing (GO:0031054)3.16356666
71DNA conformation change (GO:0071103)3.15813347
72negative regulation of chromosome segregation (GO:0051985)3.15537208
73monoubiquitinated protein deubiquitination (GO:0035520)3.15151964
74attachment of spindle microtubules to kinetochore (GO:0008608)3.13982332
75ribosome biogenesis (GO:0042254)3.13484065
76chromatin remodeling at centromere (GO:0031055)3.11522873
77ATP-dependent chromatin remodeling (GO:0043044)3.11068824
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10953150
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10953150
80negative regulation of sister chromatid segregation (GO:0033046)3.10953150
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.10953150
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10856388
83regulation of sister chromatid cohesion (GO:0007063)3.10280063
84tRNA aminoacylation for protein translation (GO:0006418)3.10081751
85chromatin assembly or disassembly (GO:0006333)3.08953225
86DNA ligation (GO:0006266)3.07858595
87amino acid activation (GO:0043038)3.06482329
88tRNA aminoacylation (GO:0043039)3.06482329
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06275960
90CENP-A containing nucleosome assembly (GO:0034080)3.04886287
91sperm-egg recognition (GO:0035036)3.04154476
92DNA topological change (GO:0006265)3.03689152
93chaperone-mediated protein complex assembly (GO:0051131)3.03608182
94spindle assembly checkpoint (GO:0071173)3.03519425
95mitotic spindle assembly checkpoint (GO:0007094)3.02921837
96spindle checkpoint (GO:0031577)3.02558299
97positive regulation of cell cycle checkpoint (GO:1901978)3.02469977
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01961521
99regulation of translational termination (GO:0006449)3.01709833
100DNA packaging (GO:0006323)3.01630214
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99439299
102peptidyl-arginine omega-N-methylation (GO:0035247)2.97798816
103mitotic spindle checkpoint (GO:0071174)2.96842751
104regulation of mitotic sister chromatid separation (GO:0010965)2.96700248
105regulation of mitotic sister chromatid segregation (GO:0033047)2.96700248
106regulation of sister chromatid segregation (GO:0033045)2.96700248
107kinetochore organization (GO:0051383)2.96581860
108telomere maintenance (GO:0000723)2.96474095
109histone H2A acetylation (GO:0043968)2.96316044
110negative regulation of histone methylation (GO:0031061)2.96095639
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.95540145
112chromatin assembly (GO:0031497)2.94875186
113sister chromatid cohesion (GO:0007062)2.94534710
114telomere organization (GO:0032200)2.92678734
115cilium or flagellum-dependent cell motility (GO:0001539)2.92440155
116negative regulation of RNA splicing (GO:0033119)2.92196246
117microtubule depolymerization (GO:0007019)2.90497288
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.88278478
119* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87561637
120* mRNA splicing, via spliceosome (GO:0000398)2.87561637
121* gene silencing by RNA (GO:0031047)2.87554659
122chromosome segregation (GO:0007059)2.83123360
123* mRNA transport (GO:0051028)2.82559504
124regulation of helicase activity (GO:0051095)2.80263534
125spliceosomal tri-snRNP complex assembly (GO:0000244)2.80007760
126regulation of mitotic spindle checkpoint (GO:1903504)2.79208411
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79208411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.06432796
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.95239033
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.13271289
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.93914195
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84921666
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59573234
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24928257
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85342679
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63490022
10AR_21909140_ChIP-Seq_LNCAP_Human2.51970724
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51630107
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.49171964
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.36983884
14* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33915671
15XRN2_22483619_ChIP-Seq_HELA_Human2.32368128
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.31541040
17MYC_22102868_ChIP-Seq_BL_Human2.24912720
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22657044
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16852576
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16772128
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.11217954
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.10586866
23* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10485335
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06976714
25VDR_23849224_ChIP-Seq_CD4+_Human1.99621703
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94982411
27FOXP3_21729870_ChIP-Seq_TREG_Human1.86537115
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83368221
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83342959
30GABP_19822575_ChIP-Seq_HepG2_Human1.80833500
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79329594
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77281263
33CIITA_25753668_ChIP-Seq_RAJI_Human1.75431670
34DCP1A_22483619_ChIP-Seq_HELA_Human1.72932936
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66680414
36KDM5A_27292631_Chip-Seq_BREAST_Human1.65227185
37* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64310678
38TTF2_22483619_ChIP-Seq_HELA_Human1.61777944
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57433475
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56397355
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56022192
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55035677
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53664846
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52006796
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48304728
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46015006
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44033956
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42106488
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41665501
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.41020865
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40409304
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40024764
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36624504
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.32968782
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32088578
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31590541
57EWS_26573619_Chip-Seq_HEK293_Human1.31128366
58ELK1_19687146_ChIP-ChIP_HELA_Human1.29388520
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29327943
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22749762
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18596339
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17933161
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16670890
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16174780
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15536787
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14782414
67TFEB_21752829_ChIP-Seq_HELA_Human1.13450206
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13198425
69VDR_21846776_ChIP-Seq_THP-1_Human1.11953753
70FUS_26573619_Chip-Seq_HEK293_Human1.11158133
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10774736
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08459320
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08058696
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07650182
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07306926
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.05966457
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05503208
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00518880
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00145858
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.99883577
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98262572
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97477507
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.97382867
84IGF1R_20145208_ChIP-Seq_DFB_Human0.94939230
85IRF1_19129219_ChIP-ChIP_H3396_Human0.92991415
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92411459
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91507419
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90820256
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88430499
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88295295
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88212814
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87399277
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85958174
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84234797
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84192054
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84071196
97CHD1_26751641_Chip-Seq_LNCaP_Human0.83401395
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.83256904
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.82570732
100* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82473928
101UTX_26944678_Chip-Seq_JUKART_Human0.82259805
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.81882258
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80955847
104* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79405151
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78069101
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77464748
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76756424
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76204927
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75920691
110ZNF274_21170338_ChIP-Seq_K562_Hela0.75831834
111* SOX2_16153702_ChIP-ChIP_HESCs_Human0.75225681
112SPI1_23547873_ChIP-Seq_NB4_Human0.74951935
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74054924
114MYB_26560356_Chip-Seq_TH1_Human0.73650893
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.73270909
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73064674
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72084107
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.72055014
119MYC_18940864_ChIP-ChIP_HL60_Human0.72051534
120TCF7_22412390_ChIP-Seq_EML_Mouse0.71841338
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71721254
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70398260
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.69259929
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68631998
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.68088103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.81029731
2MP0010094_abnormal_chromosome_stability4.54417018
3MP0003111_abnormal_nucleus_morphology4.51419014
4MP0004957_abnormal_blastocyst_morpholog4.05399664
5MP0003077_abnormal_cell_cycle3.85989520
6MP0008057_abnormal_DNA_replication3.83670560
7MP0008877_abnormal_DNA_methylation3.13384105
8MP0008058_abnormal_DNA_repair2.95915994
9MP0001730_embryonic_growth_arrest2.86368148
10MP0008007_abnormal_cellular_replicative2.83257489
11MP0005410_abnormal_fertilization2.69557620
12MP0003123_paternal_imprinting2.59359390
13MP0009697_abnormal_copulation2.48707846
14MP0008932_abnormal_embryonic_tissue2.48424727
15MP0010352_gastrointestinal_tract_polyps2.48341646
16MP0002009_preneoplasia2.46989143
17MP0000350_abnormal_cell_proliferation2.34380388
18MP0010307_abnormal_tumor_latency2.33534244
19MP0010030_abnormal_orbit_morphology2.11899298
20MP0001672_abnormal_embryogenesis/_devel2.00043473
21MP0005380_embryogenesis_phenotype2.00043473
22MP0001697_abnormal_embryo_size1.98135801
23MP0002084_abnormal_developmental_patter1.89482498
24MP0002396_abnormal_hematopoietic_system1.88900952
25MP0001929_abnormal_gametogenesis1.87971711
26MP0003984_embryonic_growth_retardation1.83673291
27MP0002088_abnormal_embryonic_growth/wei1.80490470
28MP0002080_prenatal_lethality1.79294086
29MP0002085_abnormal_embryonic_tissue1.75693410
30MP0002210_abnormal_sex_determination1.73848803
31MP0004197_abnormal_fetal_growth/weight/1.73549623
32MP0004808_abnormal_hematopoietic_stem1.71935078
33MP0003121_genomic_imprinting1.69449088
34MP0010678_abnormal_skin_adnexa1.66378027
35MP0000537_abnormal_urethra_morphology1.65907826
36MP0002086_abnormal_extraembryonic_tissu1.59347943
37MP0005076_abnormal_cell_differentiation1.58664741
38MP0003698_abnormal_male_reproductive1.54471944
39MP0001145_abnormal_male_reproductive1.53917754
40MP0003705_abnormal_hypodermis_morpholog1.52508787
41MP0000383_abnormal_hair_follicle1.51600870
42MP0003786_premature_aging1.49584761
43MP0002653_abnormal_ependyma_morphology1.47507663
44MP0003941_abnormal_skin_development1.47326323
45MP0000313_abnormal_cell_death1.41621301
46MP0003950_abnormal_plasma_membrane1.38693665
47MP0003890_abnormal_embryonic-extraembry1.38584616
48MP0001661_extended_life_span1.35937661
49MP0001293_anophthalmia1.33159665
50MP0000490_abnormal_crypts_of1.29850718
51MP0002019_abnormal_tumor_incidence1.28606265
52MP0006035_abnormal_mitochondrial_morpho1.25878997
53MP0000653_abnormal_sex_gland1.24559763
54MP0000703_abnormal_thymus_morphology1.23143665
55MP0004233_abnormal_muscle_weight1.18591391
56MP0003763_abnormal_thymus_physiology1.17045340
57MP0003567_abnormal_fetal_cardiomyocyte1.15508570
58MP0009672_abnormal_birth_weight1.15138129
59MP0000647_abnormal_sebaceous_gland1.14581991
60MP0000428_abnormal_craniofacial_morphol1.08964682
61MP0003119_abnormal_digestive_system1.06119387
62MP0009053_abnormal_anal_canal1.05718717
63MP0001545_abnormal_hematopoietic_system1.04711484
64MP0005397_hematopoietic_system_phenotyp1.04711484
65MP0000427_abnormal_hair_cycle1.04637186
66MP0002161_abnormal_fertility/fecundity1.04560204
67MP0009703_decreased_birth_body1.04546224
68MP0002160_abnormal_reproductive_system1.02172075
69MP0001849_ear_inflammation1.00888174
70MP0000358_abnormal_cell_content/0.96712163
71MP0009278_abnormal_bone_marrow0.96672486
72MP0002092_abnormal_eye_morphology0.94844869
73MP0002398_abnormal_bone_marrow0.94392703
74MP0003385_abnormal_body_wall0.93746805
75MP0004272_abnormal_basement_membrane0.93121166
76MP0009333_abnormal_splenocyte_physiolog0.92544391
77MP0005408_hypopigmentation0.92424380
78MP0003221_abnormal_cardiomyocyte_apopto0.90325606
79MP0005187_abnormal_penis_morphology0.88386143
80MP0003115_abnormal_respiratory_system0.87940909
81MP0006054_spinal_hemorrhage0.87893244
82MP0003943_abnormal_hepatobiliary_system0.87683657
83MP0000733_abnormal_muscle_development0.87405369
84MP0003315_abnormal_perineum_morphology0.85955285
85MP0002102_abnormal_ear_morphology0.85172072
86MP0003937_abnormal_limbs/digits/tail_de0.84912026
87MP0002722_abnormal_immune_system0.83902927
88MP0003718_maternal_effect0.83737429
89MP0002111_abnormal_tail_morphology0.80961335
90MP0005384_cellular_phenotype0.80907787
91MP0002751_abnormal_autonomic_nervous0.79243076
92MP0004264_abnormal_extraembryonic_tissu0.77870118
93MP0002233_abnormal_nose_morphology0.77166069
94MP0005621_abnormal_cell_physiology0.75359865
95MP0003861_abnormal_nervous_system0.74259836
96MP0008770_decreased_survivor_rate0.72124276
97MP0000689_abnormal_spleen_morphology0.71188343
98MP0001299_abnormal_eye_distance/0.67760862
99MP0002089_abnormal_postnatal_growth/wei0.67554498
100MP0005501_abnormal_skin_physiology0.66699073
101MP0002877_abnormal_melanocyte_morpholog0.66698645
102MP0005023_abnormal_wound_healing0.66613020
103MP0005171_absent_coat_pigmentation0.66337483
104MP0002098_abnormal_vibrissa_morphology0.66247828
105MP0000569_abnormal_digit_pigmentation0.66140177
106MP0002938_white_spotting0.65822528
107MP0000377_abnormal_hair_follicle0.65517634
108MP0003935_abnormal_craniofacial_develop0.65056115
109MP0003787_abnormal_imprinting0.64915689
110MP0005389_reproductive_system_phenotype0.64611127
111MP0005391_vision/eye_phenotype0.63996322
112MP0002269_muscular_atrophy0.63692828
113MP0002429_abnormal_blood_cell0.63528646
114MP0001915_intracranial_hemorrhage0.63345372
115MP0010234_abnormal_vibrissa_follicle0.62773053
116MP0000579_abnormal_nail_morphology0.62281104
117MP0005395_other_phenotype0.61559783
118MP0001186_pigmentation_phenotype0.60886343
119MP0002697_abnormal_eye_size0.60535148
120MP0002925_abnormal_cardiovascular_devel0.60194457
121MP0004185_abnormal_adipocyte_glucose0.59057591
122MP0004133_heterotaxia0.58864315
123MP0003755_abnormal_palate_morphology0.58036137
124MP0002282_abnormal_trachea_morphology0.57330700
125MP0000432_abnormal_head_morphology0.57328047
126MP0002006_tumorigenesis0.57077426
127MP0002114_abnormal_axial_skeleton0.57020442
128MP0003566_abnormal_cell_adhesion0.56767723
129MP0004782_abnormal_surfactant_physiolog0.56307881
130MP0001727_abnormal_embryo_implantation0.55721873
131MP0002234_abnormal_pharynx_morphology0.55687486
132MP0001286_abnormal_eye_development0.55293224
133MP0002932_abnormal_joint_morphology0.55270346

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.86745678
2Abnormality of the anterior horn cell (HP:0006802)3.82054994
3Degeneration of anterior horn cells (HP:0002398)3.82054994
4Selective tooth agenesis (HP:0001592)3.75863659
5Birth length less than 3rd percentile (HP:0003561)3.47925562
6Medulloblastoma (HP:0002885)3.15688920
7Increased nuchal translucency (HP:0010880)3.14788728
8Central scotoma (HP:0000603)3.13300023
9Impulsivity (HP:0100710)3.10225240
10Nephroblastoma (Wilms tumor) (HP:0002667)3.05916518
11Embryonal renal neoplasm (HP:0011794)2.91719988
12Proximal placement of thumb (HP:0009623)2.91373802
13Abnormality of the lower motor neuron (HP:0002366)2.82595689
14Colon cancer (HP:0003003)2.81909573
15Cortical dysplasia (HP:0002539)2.80993862
16Atrophy/Degeneration involving motor neurons (HP:0007373)2.80313212
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77047970
18Deviation of the thumb (HP:0009603)2.76808971
19Abnormality of chromosome stability (HP:0003220)2.72183334
20Abnormality of DNA repair (HP:0003254)2.71082609
21Astrocytoma (HP:0009592)2.69198231
22Abnormality of the astrocytes (HP:0100707)2.69198231
23Amyotrophic lateral sclerosis (HP:0007354)2.68522714
24Poikiloderma (HP:0001029)2.66805762
25Abnormality of cells of the erythroid lineage (HP:0012130)2.61255100
26Chromsome breakage (HP:0040012)2.59630348
27Patellar aplasia (HP:0006443)2.57647812
28Hypoplasia of the capital femoral epiphysis (HP:0003090)2.51546741
29Meckel diverticulum (HP:0002245)2.51236286
30Prominent nose (HP:0000448)2.50456011
31Basal cell carcinoma (HP:0002671)2.49989434
32Volvulus (HP:0002580)2.47795557
33Heterotopia (HP:0002282)2.47767349
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47637098
35Clubbing of toes (HP:0100760)2.46815513
36Cutaneous melanoma (HP:0012056)2.45480860
37Entropion (HP:0000621)2.44421113
38Reticulocytopenia (HP:0001896)2.44038426
39Abnormal number of erythroid precursors (HP:0012131)2.43526380
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.43294968
41Aplasia/Hypoplasia of the patella (HP:0006498)2.43073972
42Rhabdomyosarcoma (HP:0002859)2.41938334
43Breast hypoplasia (HP:0003187)2.40674719
4411 pairs of ribs (HP:0000878)2.39441192
45Abnormality of the ileum (HP:0001549)2.39307764
46Atresia of the external auditory canal (HP:0000413)2.38249265
47Abnormality of the preputium (HP:0100587)2.35578237
48Short 4th metacarpal (HP:0010044)2.33571878
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33571878
50Small intestinal stenosis (HP:0012848)2.28282246
51Duodenal stenosis (HP:0100867)2.28282246
52Oral leukoplakia (HP:0002745)2.27574385
53Missing ribs (HP:0000921)2.27180623
54Supernumerary spleens (HP:0009799)2.26994760
55Carpal bone hypoplasia (HP:0001498)2.25802922
56Ectopic kidney (HP:0000086)2.25759080
57Abnormality of glycolysis (HP:0004366)2.25554538
58Abnormality of chromosome segregation (HP:0002916)2.25145360
59Glioma (HP:0009733)2.25144581
60Myelodysplasia (HP:0002863)2.24889430
61Microvesicular hepatic steatosis (HP:0001414)2.24383014
62Agnosia (HP:0010524)2.22461976
63High pitched voice (HP:0001620)2.22443032
64Neoplasm of the pancreas (HP:0002894)2.21454486
65Progressive inability to walk (HP:0002505)2.20285617
66Nasal polyposis (HP:0100582)2.19192358
67Absent thumb (HP:0009777)2.18638659
68Sloping forehead (HP:0000340)2.16920174
69Facial hemangioma (HP:0000329)2.16721487
70Chronic bronchitis (HP:0004469)2.15124142
71Multiple enchondromatosis (HP:0005701)2.12509303
72Cerebral hypomyelination (HP:0006808)2.11944260
73Increased serum pyruvate (HP:0003542)2.11414718
74Cafe-au-lait spot (HP:0000957)2.10688953
75Abnormality of the labia minora (HP:0012880)2.09040284
76Neoplasm of the colon (HP:0100273)2.08867672
77Overlapping toe (HP:0001845)2.08636717
78Pelvic girdle muscle weakness (HP:0003749)2.08487629
79Absent radius (HP:0003974)2.08122437
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.07992639
81Hypoplasia of the fovea (HP:0007750)2.07992639
82Sandal gap (HP:0001852)2.07118953
83Trismus (HP:0000211)2.06999730
84Spastic diplegia (HP:0001264)2.06678596
85Neoplasm of striated muscle (HP:0009728)2.06383157
86Hyperacusis (HP:0010780)2.04746686
87Abnormal number of incisors (HP:0011064)2.03147075
88Duplicated collecting system (HP:0000081)2.02584356
89Abnormality of the carotid arteries (HP:0005344)2.01851865
90Type II lissencephaly (HP:0007260)2.01527344
91Acute myeloid leukemia (HP:0004808)2.00594224
92Retinal dysplasia (HP:0007973)2.00054147
93Absent/shortened dynein arms (HP:0200106)1.97485691
94Dynein arm defect of respiratory motile cilia (HP:0012255)1.97485691
95Absent epiphyses (HP:0010577)1.97093157
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97093157
97Shoulder girdle muscle weakness (HP:0003547)1.96705792
98Abnormal lung lobation (HP:0002101)1.96663179
99Papillary thyroid carcinoma (HP:0002895)1.94927130
100Aplasia involving forearm bones (HP:0009822)1.94143190
101Absent forearm bone (HP:0003953)1.94143190
102Renal duplication (HP:0000075)1.92451448
103Facial cleft (HP:0002006)1.92072795
104Abnormality of the pons (HP:0007361)1.90762783
105Squamous cell carcinoma (HP:0002860)1.89938236
106Postnatal microcephaly (HP:0005484)1.88957571
107Abnormality of the calcaneus (HP:0008364)1.88383913
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88284227
109Scotoma (HP:0000575)1.88205753
110Glossoptosis (HP:0000162)1.87622813
111Choanal atresia (HP:0000453)1.86330117
112Abnormality of the duodenum (HP:0002246)1.85981576
113Neoplasm of the small intestine (HP:0100833)1.85331465
114Partial agenesis of the corpus callosum (HP:0001338)1.84640665
115Spinal muscular atrophy (HP:0007269)1.84333166
116Deep philtrum (HP:0002002)1.83827491
117Renal cortical cysts (HP:0000803)1.83776846
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.82799850
119Bronchitis (HP:0012387)1.82345835
120Hypoplasia of the pons (HP:0012110)1.80952096
121Personality changes (HP:0000751)1.80516957
122Capillary hemangiomas (HP:0005306)1.79722335
123Cutis marmorata (HP:0000965)1.77971587
124Rough bone trabeculation (HP:0100670)1.77812637
125Microretrognathia (HP:0000308)1.77588360
126Horseshoe kidney (HP:0000085)1.77414149
127Short ribs (HP:0000773)1.77053868
128Arteriovenous malformation (HP:0100026)1.76483246
129Tubulointerstitial nephritis (HP:0001970)1.75253388
130Abnormal biliary tract morphology (HP:0012440)1.74771025
131Premature ovarian failure (HP:0008209)1.74118477
132Tracheoesophageal fistula (HP:0002575)1.72311973
133Bone marrow hypocellularity (HP:0005528)1.71685007
134Abnormal protein N-linked glycosylation (HP:0012347)1.71538093
135Abnormal protein glycosylation (HP:0012346)1.71538093
136Abnormal glycosylation (HP:0012345)1.71538093
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71538093
138Rhinitis (HP:0012384)1.71369966
139Broad distal phalanx of finger (HP:0009836)1.70854666
140Biliary tract neoplasm (HP:0100574)1.70755371
141Neoplasm of the oral cavity (HP:0100649)1.70339853
142Oligodactyly (hands) (HP:0001180)1.70081659
143Skin tags (HP:0010609)1.69993309
144Ankyloglossia (HP:0010296)1.69942109
145Bifid tongue (HP:0010297)1.69861360
146Embryonal neoplasm (HP:0002898)1.68699216
147Progressive hearing impairment (HP:0001730)1.66364857
148Astigmatism (HP:0000483)1.65977874
149Type I transferrin isoform profile (HP:0003642)1.65934004
150Abnormality of the fovea (HP:0000493)1.65779176
151Breast carcinoma (HP:0003002)1.65161973
152Diastasis recti (HP:0001540)1.64844589
153Abnormality of oral frenula (HP:0000190)1.64416760
154Malignant gastrointestinal tract tumors (HP:0006749)1.63618402
155Gastrointestinal carcinoma (HP:0002672)1.63618402
156Cystic hygroma (HP:0000476)1.59771299
157Uterine neoplasm (HP:0010784)1.58118484
158Acute lymphatic leukemia (HP:0006721)1.58026837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.64030500
2CDC74.55806925
3WEE13.62242216
4NEK23.55528629
5PBK2.67364416
6PDK32.65967054
7PDK42.65967054
8EEF2K2.57058826
9PASK2.31718544
10EIF2AK12.21003520
11TSSK62.19932575
12TTK2.11947329
13CDK122.09891367
14NEK12.01183630
15SRPK11.97142379
16MAP3K101.96018540
17TESK11.94884851
18PLK11.78791094
19TESK21.76129683
20BCR1.73458263
21ATR1.72275631
22BRSK21.71802588
23ZAK1.68887338
24PKN21.66465305
25MKNK11.61269845
26SCYL21.58910601
27DYRK31.56330195
28PLK41.56268607
29MST41.53830672
30TRIB31.53684284
31CDK41.51588816
32CHEK11.49494652
33PLK31.49305250
34CDK191.48654757
35STK101.46998099
36RPS6KB21.43249687
37LATS11.38401564
38TRIM281.37864073
39AURKB1.37388148
40PNCK1.33352329
41RPS6KA41.31669461
42CHEK21.31390324
43CDK71.30819537
44MET1.29115650
45PDK21.27881495
46MAP3K81.26914468
47ACVR1B1.26470207
48BRSK11.25016503
49CSNK1G31.24899867
50MAP3K41.23670413
51ALK1.22206023
52CSNK1A1L1.20179845
53ERBB31.16548361
54CSNK1G11.14407085
55ICK1.09721493
56PAK41.09715183
57STK38L1.08461199
58TGFBR11.05992996
59EIF2AK21.05360695
60AURKA1.04368456
61CCNB11.03728004
62NEK90.99916132
63MELK0.99027661
64ATM0.96871737
65BMPR1B0.96827274
66EIF2AK30.96404291
67MST1R0.96002873
68NUAK10.95685026
69KSR10.95581735
70CDK20.94408187
71VRK10.91764505
72TAF10.90241518
73MAP4K10.89976630
74STK30.89208461
75ERBB40.86038077
76CSNK1G20.85698982
77CDK60.85533778
78MKNK20.79731189
79SMG10.78615710
80MTOR0.77359561
81FGFR10.76850508
82BRD40.76074788
83PAK10.75830770
84FRK0.75564795
85EPHA20.71890138
86CDK10.70356670
87STK390.70214464
88MAP2K70.69011290
89PRKD30.68764956
90STK40.66308129
91TLK10.66253964
92LRRK20.65684183
93PIM10.65350628
94GRK60.64893380
95NME20.64492119
96LATS20.63517850
97TRPM70.62617244
98PAK20.61961872
99CSNK2A20.58533163
100AKT30.58131438
101FLT30.56865959
102ZAP700.54723741
103CDK80.51146706
104STK160.47805580
105MAPKAPK50.46957956
106CSNK1E0.46247221
107MAP2K30.46168848
108PLK20.44694566
109MAPK110.44410575
110CSNK2A10.44341865
111RAF10.44034376
112DYRK1B0.43581840
113TNIK0.43512061
114CAMK1G0.41688348
115PTK60.41192136
116NME10.40625692
117PRKDC0.39581198
118MAP4K20.38231262
119AKT20.37487115
120MAP3K60.34352738
121CSNK1D0.33246363
122VRK20.33234972
123KSR20.32976676
124KDR0.32906949
125PDGFRA0.32451222
126TYRO30.31387494
127CDK11A0.28644913
128FGFR30.28547452
129MARK30.27546648
130PRKCI0.26973885
131CDK150.26797487
132TTN0.26450636
133MAPK140.25753522
134CDK140.25684817
135CLK10.25321239
136CDK180.24457714
137MAP3K50.24402787
138GSK3B0.22991121
139CDK90.22087446
140LIMK10.21696139

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74790038
2Mismatch repair_Homo sapiens_hsa034303.79595368
3* RNA transport_Homo sapiens_hsa030133.67606608
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57836265
5* Spliceosome_Homo sapiens_hsa030403.47536718
6Cell cycle_Homo sapiens_hsa041103.08544372
7Base excision repair_Homo sapiens_hsa034102.89679452
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61736825
9Nucleotide excision repair_Homo sapiens_hsa034202.55546856
10Homologous recombination_Homo sapiens_hsa034402.50779643
11Proteasome_Homo sapiens_hsa030502.49601812
12One carbon pool by folate_Homo sapiens_hsa006702.45749889
13RNA polymerase_Homo sapiens_hsa030202.42066457
14* mRNA surveillance pathway_Homo sapiens_hsa030152.29938248
15Fanconi anemia pathway_Homo sapiens_hsa034602.26604865
16Pyrimidine metabolism_Homo sapiens_hsa002401.98832233
17Basal transcription factors_Homo sapiens_hsa030221.92348918
18Ribosome_Homo sapiens_hsa030101.89520408
19Non-homologous end-joining_Homo sapiens_hsa034501.83799225
20RNA degradation_Homo sapiens_hsa030181.83458672
21Vitamin B6 metabolism_Homo sapiens_hsa007501.72387537
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61743854
23Oocyte meiosis_Homo sapiens_hsa041141.60545876
24p53 signaling pathway_Homo sapiens_hsa041151.52233556
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44088623
26Antigen processing and presentation_Homo sapiens_hsa046121.35686203
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32688609
28Viral carcinogenesis_Homo sapiens_hsa052031.32512047
29Epstein-Barr virus infection_Homo sapiens_hsa051691.27926244
30Selenocompound metabolism_Homo sapiens_hsa004501.21809079
31Steroid biosynthesis_Homo sapiens_hsa001001.19092775
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18517572
33Protein export_Homo sapiens_hsa030601.18000955
34Systemic lupus erythematosus_Homo sapiens_hsa053221.11853497
35Purine metabolism_Homo sapiens_hsa002301.10382272
36Propanoate metabolism_Homo sapiens_hsa006401.08660437
37Pentose phosphate pathway_Homo sapiens_hsa000301.04736984
38HTLV-I infection_Homo sapiens_hsa051661.02635793
39Biosynthesis of amino acids_Homo sapiens_hsa012301.02528045
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97106850
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.95076036
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93026210
43MicroRNAs in cancer_Homo sapiens_hsa052060.89946279
44Thyroid cancer_Homo sapiens_hsa052160.88799881
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87929058
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.85513248
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84651386
48Chronic myeloid leukemia_Homo sapiens_hsa052200.83812966
49Herpes simplex infection_Homo sapiens_hsa051680.80949086
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76479082
51Small cell lung cancer_Homo sapiens_hsa052220.70731272
52mTOR signaling pathway_Homo sapiens_hsa041500.69219424
53Basal cell carcinoma_Homo sapiens_hsa052170.66709783
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66135730
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65407167
56Colorectal cancer_Homo sapiens_hsa052100.64721967
57Hippo signaling pathway_Homo sapiens_hsa043900.64413665
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63908847
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.63512106
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62760452
61Shigellosis_Homo sapiens_hsa051310.62483422
62Alcoholism_Homo sapiens_hsa050340.61945933
63N-Glycan biosynthesis_Homo sapiens_hsa005100.61448341
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58036873
65Primary immunodeficiency_Homo sapiens_hsa053400.57444040
66Notch signaling pathway_Homo sapiens_hsa043300.56058835
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55990206
68Carbon metabolism_Homo sapiens_hsa012000.55564594
69Bladder cancer_Homo sapiens_hsa052190.55488968
70Hedgehog signaling pathway_Homo sapiens_hsa043400.54600021
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53382105
72Fatty acid biosynthesis_Homo sapiens_hsa000610.52090392
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51696603
74Legionellosis_Homo sapiens_hsa051340.50446059
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50241065
76Non-small cell lung cancer_Homo sapiens_hsa052230.50108775
77T cell receptor signaling pathway_Homo sapiens_hsa046600.46837026
78Hepatitis B_Homo sapiens_hsa051610.45883855
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45720373
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44995763
81Apoptosis_Homo sapiens_hsa042100.44548426
82Viral myocarditis_Homo sapiens_hsa054160.43915177
83Acute myeloid leukemia_Homo sapiens_hsa052210.43620695
84Fatty acid metabolism_Homo sapiens_hsa012120.42939169
85Inositol phosphate metabolism_Homo sapiens_hsa005620.41143077
86HIF-1 signaling pathway_Homo sapiens_hsa040660.40823658
87TGF-beta signaling pathway_Homo sapiens_hsa043500.40740529
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39446966
89Melanoma_Homo sapiens_hsa052180.38666848
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37393396
91Prostate cancer_Homo sapiens_hsa052150.36563939
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36164734
93Glucagon signaling pathway_Homo sapiens_hsa049220.36033164
94Sulfur relay system_Homo sapiens_hsa041220.35999066
95VEGF signaling pathway_Homo sapiens_hsa043700.35733415
96Fructose and mannose metabolism_Homo sapiens_hsa000510.35305216
97Adherens junction_Homo sapiens_hsa045200.35022626
98Pathways in cancer_Homo sapiens_hsa052000.33315165
99Endometrial cancer_Homo sapiens_hsa052130.32017655
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.31850695
101B cell receptor signaling pathway_Homo sapiens_hsa046620.31771997
102Pancreatic cancer_Homo sapiens_hsa052120.31453993
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30769345
104Measles_Homo sapiens_hsa051620.30494371
105Proteoglycans in cancer_Homo sapiens_hsa052050.29854157
106Wnt signaling pathway_Homo sapiens_hsa043100.29647513
107Pyruvate metabolism_Homo sapiens_hsa006200.28983328
108Sulfur metabolism_Homo sapiens_hsa009200.28571319
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28396754
110Fatty acid elongation_Homo sapiens_hsa000620.28370071
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.27644177
112AMPK signaling pathway_Homo sapiens_hsa041520.25438100
113Arginine and proline metabolism_Homo sapiens_hsa003300.24872572
114Metabolic pathways_Homo sapiens_hsa011000.24851174
115Butanoate metabolism_Homo sapiens_hsa006500.23874551
116Dorso-ventral axis formation_Homo sapiens_hsa043200.23362895
117Renal cell carcinoma_Homo sapiens_hsa052110.22945666
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22223419
119Circadian rhythm_Homo sapiens_hsa047100.21559806
120Tight junction_Homo sapiens_hsa045300.20711465
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20624605
122Lysine degradation_Homo sapiens_hsa003100.20140830
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20114922
124Folate biosynthesis_Homo sapiens_hsa007900.19459738
125Endocytosis_Homo sapiens_hsa041440.18729792
126Glioma_Homo sapiens_hsa052140.18577873
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18263276
128beta-Alanine metabolism_Homo sapiens_hsa004100.17782490
129Renin-angiotensin system_Homo sapiens_hsa046140.17676079
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16481887

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