NCBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)4.70142662
2protein deneddylation (GO:0000338)4.42454370
3chaperone-mediated protein transport (GO:0072321)4.27592577
4formation of translation preinitiation complex (GO:0001731)4.12806049
5proteasome assembly (GO:0043248)4.09382436
6DNA damage response, detection of DNA damage (GO:0042769)4.00161017
7histone H2A acetylation (GO:0043968)3.93968622
8transcription elongation from RNA polymerase III promoter (GO:0006385)3.89451073
9termination of RNA polymerase III transcription (GO:0006386)3.89451073
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81309818
11DNA replication checkpoint (GO:0000076)3.81185891
12purine nucleobase biosynthetic process (GO:0009113)3.78273654
13* spliceosomal snRNP assembly (GO:0000387)3.76941362
14nucleobase biosynthetic process (GO:0046112)3.75499074
15maturation of SSU-rRNA (GO:0030490)3.75173733
16* 7-methylguanosine mRNA capping (GO:0006370)3.67754596
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67383093
18mitotic metaphase plate congression (GO:0007080)3.66465626
19DNA double-strand break processing (GO:0000729)3.66229002
20* RNA capping (GO:0036260)3.63150853
21* 7-methylguanosine RNA capping (GO:0009452)3.63150853
22establishment of viral latency (GO:0019043)3.62458376
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.60620805
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60126552
25CENP-A containing nucleosome assembly (GO:0034080)3.60054826
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55735713
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.54861660
28spliceosomal complex assembly (GO:0000245)3.51376777
29negative regulation of ligase activity (GO:0051352)3.49608765
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49608765
31protein neddylation (GO:0045116)3.47263750
32chromatin remodeling at centromere (GO:0031055)3.46242290
33ATP synthesis coupled proton transport (GO:0015986)3.45299597
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45299597
35tRNA aminoacylation for protein translation (GO:0006418)3.40579898
36ribosome biogenesis (GO:0042254)3.38696029
37amino acid activation (GO:0043038)3.37641921
38tRNA aminoacylation (GO:0043039)3.37641921
39ribosomal small subunit assembly (GO:0000028)3.37519124
40viral mRNA export from host cell nucleus (GO:0046784)3.37292709
41DNA strand elongation involved in DNA replication (GO:0006271)3.35741540
42kinetochore assembly (GO:0051382)3.34277162
43ribonucleoprotein complex biogenesis (GO:0022613)3.33448653
44ribosomal small subunit biogenesis (GO:0042274)3.33071085
45establishment of integrated proviral latency (GO:0075713)3.30626881
46DNA ligation (GO:0006266)3.30503168
47ribosomal large subunit biogenesis (GO:0042273)3.28491061
48DNA strand elongation (GO:0022616)3.26594804
49DNA replication initiation (GO:0006270)3.25807430
50L-serine metabolic process (GO:0006563)3.25437049
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24368002
52kinetochore organization (GO:0051383)3.22879840
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.20799311
54DNA replication-independent nucleosome assembly (GO:0006336)3.20301125
55DNA replication-independent nucleosome organization (GO:0034724)3.20301125
56ribosome assembly (GO:0042255)3.17962763
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.16455924
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16455924
59telomere maintenance via semi-conservative replication (GO:0032201)3.16189547
60non-recombinational repair (GO:0000726)3.15299529
61double-strand break repair via nonhomologous end joining (GO:0006303)3.15299529
62DNA deamination (GO:0045006)3.15258635
63mitochondrial RNA metabolic process (GO:0000959)3.13574787
64regulation of helicase activity (GO:0051095)3.11452885
65positive regulation of ligase activity (GO:0051351)3.10567703
66translational termination (GO:0006415)3.10393962
67transcription-coupled nucleotide-excision repair (GO:0006283)3.10058341
68viral transcription (GO:0019083)3.09315728
69cellular component biogenesis (GO:0044085)3.09271138
70translational initiation (GO:0006413)3.07618707
71rRNA processing (GO:0006364)3.07593282
72histone exchange (GO:0043486)3.07168721
73regulation of cellular amino acid metabolic process (GO:0006521)3.06301069
74metaphase plate congression (GO:0051310)3.06093504
75translation (GO:0006412)3.05975966
76cotranslational protein targeting to membrane (GO:0006613)3.05653696
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05601433
78IMP biosynthetic process (GO:0006188)3.04926716
79rRNA modification (GO:0000154)3.04603702
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.04546249
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04051698
82telomere maintenance via recombination (GO:0000722)3.02280483
83peptidyl-histidine modification (GO:0018202)3.01956873
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00390237
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00390237
86protein targeting to ER (GO:0045047)2.98710085
87* transcription elongation from RNA polymerase II promoter (GO:0006368)2.98487581
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97892213
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97892213
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97892213
91rRNA metabolic process (GO:0016072)2.97115114
92peptidyl-arginine methylation (GO:0018216)2.97043153
93peptidyl-arginine N-methylation (GO:0035246)2.97043153
94positive regulation of mitochondrial fission (GO:0090141)2.95851695
95guanosine-containing compound biosynthetic process (GO:1901070)2.94507389
96nuclear pore organization (GO:0006999)2.94031997
97histone arginine methylation (GO:0034969)2.93734758
98cholesterol biosynthetic process (GO:0006695)2.93346223
99DNA topological change (GO:0006265)2.93074350
100DNA unwinding involved in DNA replication (GO:0006268)2.93053344
101signal transduction involved in DNA damage checkpoint (GO:0072422)2.93013426
102signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93013426
103signal transduction involved in cell cycle checkpoint (GO:0072395)2.91983543
104mitotic recombination (GO:0006312)2.91974022
105peptidyl-arginine omega-N-methylation (GO:0035247)2.91438040
106pseudouridine synthesis (GO:0001522)2.90840561
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.90077785
108termination of RNA polymerase I transcription (GO:0006363)2.89346785
109transcription from RNA polymerase I promoter (GO:0006360)2.88458641
110regulation of mitochondrial translation (GO:0070129)2.88229228
111* DNA-templated transcription, elongation (GO:0006354)2.87160012
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85697175
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.85697175
114NADH dehydrogenase complex assembly (GO:0010257)2.85697175
115translational elongation (GO:0006414)2.85029042
116protein localization to endoplasmic reticulum (GO:0070972)2.84607042
117negative regulation of DNA recombination (GO:0045910)2.83949585
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83831479
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83679922
120ubiquinone metabolic process (GO:0006743)2.83573352
121de novo protein folding (GO:0006458)2.83338850
122maturation of 5.8S rRNA (GO:0000460)2.83189660
123establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82262299
124cell cycle G1/S phase transition (GO:0044843)2.81258400
125G1/S transition of mitotic cell cycle (GO:0000082)2.81258400
126attachment of spindle microtubules to kinetochore (GO:0008608)2.72150438
127pyrimidine dimer repair (GO:0006290)2.70938891
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69279748
129somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69279748
130isotype switching (GO:0045190)2.69279748
131mitotic spindle checkpoint (GO:0071174)2.68936398
132sterol biosynthetic process (GO:0016126)2.68633518
133IMP metabolic process (GO:0046040)2.68035760
134transcription from mitochondrial promoter (GO:0006390)2.67976633
135tRNA metabolic process (GO:0006399)2.67750205
136de novo posttranslational protein folding (GO:0051084)2.67343626
137pyrimidine nucleobase catabolic process (GO:0006208)2.64962537
138ubiquinone biosynthetic process (GO:0006744)2.64638856
139RNA-dependent DNA replication (GO:0006278)2.61841452
140spindle checkpoint (GO:0031577)2.61197577
141regulation of development, heterochronic (GO:0040034)2.61091206
142rRNA methylation (GO:0031167)2.58582750
143ATP-dependent chromatin remodeling (GO:0043044)2.57425692
144somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.57047026
145somatic cell DNA recombination (GO:0016444)2.57047026
146protein localization to kinetochore (GO:0034501)2.56819486
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54421675
148protein-cofactor linkage (GO:0018065)2.54297051
149DNA catabolic process, exonucleolytic (GO:0000738)2.53205815
150* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.53154574
151* mRNA splicing, via spliceosome (GO:0000398)2.53154574
152* RNA splicing, via transesterification reactions (GO:0000375)2.52511054
153negative regulation of mRNA processing (GO:0050686)2.50570413
154negative regulation of RNA splicing (GO:0033119)2.50097980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.99760523
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55036935
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.50146887
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.12868890
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.03931321
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.70997554
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.57830780
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48606435
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.44654265
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31369389
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27264097
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17078996
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04596370
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98851025
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93242516
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93023231
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87187676
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78095835
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65893971
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57704732
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55083799
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54344256
23VDR_23849224_ChIP-Seq_CD4+_Human2.52433218
24* XRN2_22483619_ChIP-Seq_HELA_Human2.51471843
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.45285455
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43920191
27DCP1A_22483619_ChIP-Seq_HELA_Human2.33537047
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32999258
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.32673639
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26917704
31* GABP_19822575_ChIP-Seq_HepG2_Human2.23713969
32ZNF274_21170338_ChIP-Seq_K562_Hela2.16408133
33FOXP3_21729870_ChIP-Seq_TREG_Human2.13241910
34TTF2_22483619_ChIP-Seq_HELA_Human2.13151901
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10676958
36ELK1_19687146_ChIP-ChIP_HELA_Human2.06171611
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06004439
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01988326
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94944425
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94806576
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93201926
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.91746659
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91627088
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91364218
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78262034
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77186802
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77070966
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.75582012
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75570140
50IGF1R_20145208_ChIP-Seq_DFB_Human1.71907759
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61154494
52AR_21909140_ChIP-Seq_LNCAP_Human1.61074420
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60328625
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55839736
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54245752
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50008980
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47700053
58CIITA_25753668_ChIP-Seq_RAJI_Human1.45543824
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.44211165
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.37229255
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33949689
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.31165162
63* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29524148
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25999239
65MYC_18940864_ChIP-ChIP_HL60_Human1.25931205
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25321841
67KDM5A_27292631_Chip-Seq_BREAST_Human1.22802300
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21033472
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20424061
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18497802
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.17876706
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17033965
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14367478
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.13276080
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12538479
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11612944
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10126443
78* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07032497
79TAF15_26573619_Chip-Seq_HEK293_Human1.06670042
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04387370
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04046890
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.02229877
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02048526
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00577941
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.99751610
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99050638
87* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97013497
88TFEB_21752829_ChIP-Seq_HELA_Human0.96920387
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95850064
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95833868
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.94864752
92* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94456892
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94047425
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92009814
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91644289
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91085396
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89702613
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.89031237
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87982069
100* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87314830
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86879171
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84889922
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84573364
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.83765754
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83322359
106EWS_26573619_Chip-Seq_HEK293_Human0.82350535
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.82164934
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81212078
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80222202
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79295316
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78296432
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76789549
113FUS_26573619_Chip-Seq_HEK293_Human0.76352279
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75080647
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73136079
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71082953
117REST_19997604_ChIP-ChIP_NEURONS_Mouse0.70143743
118IRF1_19129219_ChIP-ChIP_H3396_Human0.67132495
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66774537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.03568745
2MP0004957_abnormal_blastocyst_morpholog3.55707307
3MP0003123_paternal_imprinting3.19711293
4MP0010094_abnormal_chromosome_stability3.00295887
5MP0003111_abnormal_nucleus_morphology2.80945866
6MP0003077_abnormal_cell_cycle2.73393147
7MP0008932_abnormal_embryonic_tissue2.68641213
8MP0008058_abnormal_DNA_repair2.65322749
9MP0008057_abnormal_DNA_replication2.39823229
10MP0008877_abnormal_DNA_methylation2.34511470
11MP0003122_maternal_imprinting2.25914398
12MP0001529_abnormal_vocalization2.20949971
13MP0010030_abnormal_orbit_morphology2.10901606
14MP0003121_genomic_imprinting2.03837187
15MP0008007_abnormal_cellular_replicative1.95038765
16MP0008789_abnormal_olfactory_epithelium1.89941412
17MP0001730_embryonic_growth_arrest1.82989247
18MP0003315_abnormal_perineum_morphology1.80126178
19MP0003221_abnormal_cardiomyocyte_apopto1.74269905
20MP0000537_abnormal_urethra_morphology1.71737280
21MP0006292_abnormal_olfactory_placode1.62341892
22MP0002638_abnormal_pupillary_reflex1.61249602
23MP0000049_abnormal_middle_ear1.60363018
24MP0002160_abnormal_reproductive_system1.59638622
25MP0001986_abnormal_taste_sensitivity1.58029006
26MP0003786_premature_aging1.57826937
27MP0003718_maternal_effect1.57384026
28MP0000350_abnormal_cell_proliferation1.55290680
29MP0001293_anophthalmia1.53203842
30MP0003890_abnormal_embryonic-extraembry1.51897093
31MP0006035_abnormal_mitochondrial_morpho1.49317680
32MP0005499_abnormal_olfactory_system1.49096693
33MP0005394_taste/olfaction_phenotype1.49096693
34MP0003937_abnormal_limbs/digits/tail_de1.47419510
35MP0002822_catalepsy1.46385458
36MP0003941_abnormal_skin_development1.45524395
37MP0005248_abnormal_Harderian_gland1.43013423
38MP0002938_white_spotting1.42216422
39MP0001984_abnormal_olfaction1.41825892
40MP0001697_abnormal_embryo_size1.39924823
41MP0002085_abnormal_embryonic_tissue1.36202934
42MP0003942_abnormal_urinary_system1.35584735
43MP0002102_abnormal_ear_morphology1.35118982
44MP0009379_abnormal_foot_pigmentation1.33608352
45MP0002210_abnormal_sex_determination1.32994736
46MP0001188_hyperpigmentation1.29695988
47MP0004270_analgesia1.28887301
48MP0002751_abnormal_autonomic_nervous1.26986612
49MP0002084_abnormal_developmental_patter1.25450896
50MP0003938_abnormal_ear_development1.23662073
51MP0009250_abnormal_appendicular_skeleto1.22267338
52MP0001346_abnormal_lacrimal_gland1.21667324
53MP0001177_atelectasis1.21297233
54MP0000647_abnormal_sebaceous_gland1.20711693
55MP0003136_yellow_coat_color1.18623358
56MP0005253_abnormal_eye_physiology1.18489502
57MP0002653_abnormal_ependyma_morphology1.18333579
58MP0002080_prenatal_lethality1.15862492
59MP0005380_embryogenesis_phenotype1.15507397
60MP0001672_abnormal_embryogenesis/_devel1.15507397
61MP0001905_abnormal_dopamine_level1.14503304
62MP0001145_abnormal_male_reproductive1.13307602
63MP0002233_abnormal_nose_morphology1.11286359
64MP0000566_synostosis1.10483418
65MP0002234_abnormal_pharynx_morphology1.10128522
66MP0002697_abnormal_eye_size1.09204842
67MP0005171_absent_coat_pigmentation1.08083863
68MP0003119_abnormal_digestive_system1.07829180
69MP0000778_abnormal_nervous_system1.04959302
70MP0004133_heterotaxia1.04583140
71MP0001929_abnormal_gametogenesis1.03175367
72MP0000631_abnormal_neuroendocrine_gland1.02727491
73MP0003861_abnormal_nervous_system1.02567710
74MP0003755_abnormal_palate_morphology1.02424254
75MP0000653_abnormal_sex_gland1.01211374
76MP0000955_abnormal_spinal_cord1.00731335
77MP0001286_abnormal_eye_development0.99371369
78MP0003984_embryonic_growth_retardation0.99222911
79MP0002163_abnormal_gland_morphology0.98206984
80MP0002932_abnormal_joint_morphology0.97711866
81MP0005391_vision/eye_phenotype0.97110289
82MP0002088_abnormal_embryonic_growth/wei0.97040238
83MP0003567_abnormal_fetal_cardiomyocyte0.96600538
84MP0006072_abnormal_retinal_apoptosis0.96259366
85MP0005389_reproductive_system_phenotype0.94963495
86MP0005187_abnormal_penis_morphology0.94920305
87MP0009703_decreased_birth_body0.93043691
88MP0009053_abnormal_anal_canal0.92460328
89MP0003880_abnormal_central_pattern0.92328506
90MP0001727_abnormal_embryo_implantation0.91576567
91MP0002249_abnormal_larynx_morphology0.90297950
92MP0001485_abnormal_pinna_reflex0.90123214
93MP0005367_renal/urinary_system_phenotyp0.88580856
94MP0000516_abnormal_urinary_system0.88580856
95MP0002114_abnormal_axial_skeleton0.87959997
96MP0000313_abnormal_cell_death0.87645713
97MP0004197_abnormal_fetal_growth/weight/0.85196879
98MP0000428_abnormal_craniofacial_morphol0.85164827
99MP0003186_abnormal_redox_activity0.84245735
100MP0006276_abnormal_autonomic_nervous0.82610591
101MP0004811_abnormal_neuron_physiology0.80278515
102MP0002111_abnormal_tail_morphology0.80097192
103MP0002177_abnormal_outer_ear0.79749987
104MP0002116_abnormal_craniofacial_bone0.78971196
105MP0000358_abnormal_cell_content/0.78611179
106MP0003698_abnormal_male_reproductive0.77155973
107MP0000762_abnormal_tongue_morphology0.77127081
108MP0002095_abnormal_skin_pigmentation0.77038709
109MP0002090_abnormal_vision0.76358091
110MP0009672_abnormal_birth_weight0.75237414
111MP0002092_abnormal_eye_morphology0.73346833
112MP0002152_abnormal_brain_morphology0.73102466
113MP0000534_abnormal_ureter_morphology0.72531768
114MP0003385_abnormal_body_wall0.72196763
115MP0002184_abnormal_innervation0.72115411
116MP0009697_abnormal_copulation0.71663072
117MP0002736_abnormal_nociception_after0.70512074
118MP0006036_abnormal_mitochondrial_physio0.70154514
119MP0002282_abnormal_trachea_morphology0.69043459
120MP0005408_hypopigmentation0.68543419
121MP0002752_abnormal_somatic_nervous0.68229898
122MP0005423_abnormal_somatic_nervous0.67819763
123MP0002081_perinatal_lethality0.66071719
124MP0000372_irregular_coat_pigmentation0.65541960
125MP0003935_abnormal_craniofacial_develop0.65331265
126MP0000678_abnormal_parathyroid_gland0.65264150
127MP0005503_abnormal_tendon_morphology0.65028772
128MP0003787_abnormal_imprinting0.64825006

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.98785009
2Abnormal mitochondria in muscle tissue (HP:0008316)3.63119163
3Increased serum pyruvate (HP:0003542)3.60403665
4Abnormality of glycolysis (HP:0004366)3.60403665
5Birth length less than 3rd percentile (HP:0003561)3.58904871
6Cerebral hypomyelination (HP:0006808)3.46822234
7Mitochondrial inheritance (HP:0001427)3.28582252
8Progressive macrocephaly (HP:0004481)3.16328272
9Acute encephalopathy (HP:0006846)3.06459908
10Increased CSF lactate (HP:0002490)3.06109151
11Cortical dysplasia (HP:0002539)2.93842976
12Degeneration of anterior horn cells (HP:0002398)2.88352483
13Abnormality of the anterior horn cell (HP:0006802)2.88352483
14Breast hypoplasia (HP:0003187)2.84898441
15Abnormality of cells of the erythroid lineage (HP:0012130)2.82730942
16Hepatocellular necrosis (HP:0001404)2.81244861
17Patellar aplasia (HP:0006443)2.78122076
18Aplasia/Hypoplasia of the patella (HP:0006498)2.75664079
19Abnormal lung lobation (HP:0002101)2.70315994
20Abnormality of the labia minora (HP:0012880)2.63624193
21Abnormal number of erythroid precursors (HP:0012131)2.62984187
22Medulloblastoma (HP:0002885)2.62461197
23Retinal dysplasia (HP:0007973)2.61876435
24Hyperglycinemia (HP:0002154)2.58352773
25Reticulocytopenia (HP:0001896)2.50865024
26Increased hepatocellular lipid droplets (HP:0006565)2.50591240
27Bifid tongue (HP:0010297)2.48768043
28Facial cleft (HP:0002006)2.46497167
29Colon cancer (HP:0003003)2.46098258
30Shoulder girdle muscle weakness (HP:0003547)2.44331482
31Volvulus (HP:0002580)2.44312005
32Ependymoma (HP:0002888)2.44160228
33Fibular aplasia (HP:0002990)2.42915051
34Absent radius (HP:0003974)2.37858161
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35948437
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.34365986
37Microvesicular hepatic steatosis (HP:0001414)2.29010841
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27751328
39Hepatic necrosis (HP:0002605)2.25123685
40Absent forearm bone (HP:0003953)2.19954663
41Aplasia involving forearm bones (HP:0009822)2.19954663
42Increased serum lactate (HP:0002151)2.19798976
43Pancreatic fibrosis (HP:0100732)2.19212580
44Meckel diverticulum (HP:0002245)2.19085518
45Rough bone trabeculation (HP:0100670)2.17886259
46Aplastic anemia (HP:0001915)2.16168349
47Multiple enchondromatosis (HP:0005701)2.15149526
48Abnormality of the metopic suture (HP:0005556)2.14028651
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11720456
50Horseshoe kidney (HP:0000085)2.11037466
51Abnormality of the ileum (HP:0001549)2.09391977
52Lissencephaly (HP:0001339)2.09094586
53Supernumerary spleens (HP:0009799)2.07774101
54Leukodystrophy (HP:0002415)2.07682030
55Exercise intolerance (HP:0003546)2.06892380
56Atresia of the external auditory canal (HP:0000413)2.06857519
57Abnormality of the musculature of the pelvis (HP:0001469)2.06369045
58Abnormality of the hip-girdle musculature (HP:0001445)2.06369045
59Lipid accumulation in hepatocytes (HP:0006561)2.05145279
60Glioma (HP:0009733)2.04948599
61Neoplasm of the adrenal gland (HP:0100631)2.04834233
62True hermaphroditism (HP:0010459)2.03367555
63Insidious onset (HP:0003587)2.03043515
64Termporal pattern (HP:0011008)2.03043515
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.02761245
66Pendular nystagmus (HP:0012043)2.02156319
67Pancreatic cysts (HP:0001737)2.00595211
68Postnatal microcephaly (HP:0005484)1.99887502
69Triphalangeal thumb (HP:0001199)1.99856420
70Decreased testicular size (HP:0008734)1.99657293
71Hepatoblastoma (HP:0002884)1.99499162
72Neonatal respiratory distress (HP:0002643)1.99228090
73Abnormality of serine family amino acid metabolism (HP:0010894)1.97317065
74Abnormality of glycine metabolism (HP:0010895)1.97317065
75Abnormality of the fetal cardiovascular system (HP:0010948)1.96923179
76Abnormal umbilical cord blood vessels (HP:0011403)1.96923179
77Single umbilical artery (HP:0001195)1.96923179
78Respiratory failure (HP:0002878)1.96351795
79Oral leukoplakia (HP:0002745)1.95098028
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94977936
81Absent epiphyses (HP:0010577)1.94977936
82Methylmalonic acidemia (HP:0002912)1.93472678
83Carpal bone hypoplasia (HP:0001498)1.92751559
84Glossoptosis (HP:0000162)1.92262234
85Abnormality of the preputium (HP:0100587)1.91682151
86CNS hypomyelination (HP:0003429)1.91599738
87Vaginal atresia (HP:0000148)1.91486023
88Secondary amenorrhea (HP:0000869)1.91149133
89Medial flaring of the eyebrow (HP:0010747)1.90619558
90Macrocytic anemia (HP:0001972)1.90583504
91Neoplasm of the adrenal cortex (HP:0100641)1.90027032
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89169695
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89169695
94Nephroblastoma (Wilms tumor) (HP:0002667)1.85561565
95Abnormality of the astrocytes (HP:0100707)1.85521325
96Astrocytoma (HP:0009592)1.85521325
97Genital tract atresia (HP:0001827)1.85463839
98Long clavicles (HP:0000890)1.85307563
99Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83140493
100Gait imbalance (HP:0002141)1.82989261
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82961315
102Congenital primary aphakia (HP:0007707)1.82554512
103Intestinal atresia (HP:0011100)1.81594232
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81522127
105Short tibia (HP:0005736)1.81377767
106Duodenal stenosis (HP:0100867)1.80928946
107Small intestinal stenosis (HP:0012848)1.80928946
108Abnormality of methionine metabolism (HP:0010901)1.80521816
109Trismus (HP:0000211)1.79682090
110Abnormality of the umbilical cord (HP:0010881)1.79676340
111Spastic diplegia (HP:0001264)1.79421092
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.79346177
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.78859756
114Chromsome breakage (HP:0040012)1.78633332
115Prominent metopic ridge (HP:0005487)1.78588592
116Abnormality of serum amino acid levels (HP:0003112)1.78295736
117Renal Fanconi syndrome (HP:0001994)1.77836491
118Nephrogenic diabetes insipidus (HP:0009806)1.77742079
119Abnormality of the phalanges of the hallux (HP:0010057)1.76902449
120Stenosis of the external auditory canal (HP:0000402)1.75555407
121Postaxial hand polydactyly (HP:0001162)1.75403831
122Proximal tubulopathy (HP:0000114)1.75303811
123Lactic acidosis (HP:0003128)1.74270129
124Abnormality of chromosome stability (HP:0003220)1.73733082
125Pelvic girdle muscle weakness (HP:0003749)1.73562241
126Rhabdomyosarcoma (HP:0002859)1.73524657
127Increased nuchal translucency (HP:0010880)1.73306218
128Agnosia (HP:0010524)1.72897296
129Abnormality of placental membranes (HP:0011409)1.72633513
130Amniotic constriction ring (HP:0009775)1.72633513
131Broad foot (HP:0001769)1.72540149
132Scrotal hypoplasia (HP:0000046)1.71481021
133Papillary thyroid carcinoma (HP:0002895)1.71113198
134Selective tooth agenesis (HP:0001592)1.70821025
135Embryonal renal neoplasm (HP:0011794)1.70401028
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70361144
137Abnormality of alanine metabolism (HP:0010916)1.70361144
138Hyperalaninemia (HP:0003348)1.70361144
139Aplasia/hypoplasia of the uterus (HP:0008684)1.70250727
140Exertional dyspnea (HP:0002875)1.69899448
141Respiratory difficulties (HP:0002880)1.69412963
142Anencephaly (HP:0002323)1.69289599
143Severe visual impairment (HP:0001141)1.68987639
144Hyperglycinuria (HP:0003108)1.68960766
145Cleft eyelid (HP:0000625)1.68565011
146Emotional lability (HP:0000712)1.67892149
147Type I transferrin isoform profile (HP:0003642)1.67880050
148Microretrognathia (HP:0000308)1.67805009
149Dandy-Walker malformation (HP:0001305)1.67377900
150Abnormal protein glycosylation (HP:0012346)1.65879768
151Abnormal glycosylation (HP:0012345)1.65879768
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65879768
153Abnormal protein N-linked glycosylation (HP:0012347)1.65879768
154Pallor (HP:0000980)1.65654890
155Sloping forehead (HP:0000340)1.64810063
156Postaxial foot polydactyly (HP:0001830)1.64499794
157Neoplasm of the colon (HP:0100273)1.62478204
158Thyroid carcinoma (HP:0002890)1.62326054
159Poor suck (HP:0002033)1.60893278
160Drooling (HP:0002307)1.60680765
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.59973382
162Facial hemangioma (HP:0000329)1.59426503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.45947801
2STK163.36492338
3TRIM283.26444885
4SRPK13.21049140
5CDC73.10498014
6EIF2AK13.06071793
7WEE13.04579879
8VRK22.62991904
9TESK22.49674964
10VRK12.38046615
11BRSK22.34282797
12CDK192.33203808
13LIMK12.20928781
14TSSK62.14660633
15MKNK12.10366893
16EIF2AK32.06901511
17MAP4K22.05081301
18NME22.03437871
19PLK32.01998751
20TLK11.97947939
21CDK81.83221012
22DYRK31.71342082
23CCNB11.69163920
24MAP2K71.68712723
25PLK41.67036389
26PLK11.65696654
27ACVR1B1.62372641
28MAP3K41.61993805
29TESK11.55780910
30TAF11.54404817
31MKNK21.53642899
32PASK1.51802798
33DYRK21.46354476
34BCR1.45908349
35NEK11.43952140
36NME11.43096594
37ZAK1.40843732
38BRSK11.37078679
39TNIK1.36285324
40NUAK11.36265351
41TTK1.33654725
42AURKA1.32944556
43CHEK21.32920074
44BRAF1.23724120
45AURKB1.15114450
46NEK21.14872071
47PLK21.13561548
48CSNK1G31.11692378
49SIK31.11573170
50CDK71.09312844
51MAP3K121.08025668
52BRD40.98468596
53BCKDK0.96774681
54MST40.96513495
55LATS20.96435382
56ATR0.96352783
57UHMK10.94341195
58PBK0.93246028
59SCYL20.88528676
60BMPR1B0.85926015
61AKT30.85892858
62CSNK1G10.85832046
63ARAF0.84650308
64RPS6KA40.84461868
65PAK40.84150634
66CASK0.80995352
67PDK20.80631545
68CHEK10.80520374
69ERBB30.78552598
70CSNK2A10.76782593
71TGFBR10.76553059
72PAK10.75673226
73STK390.74300635
74CSNK2A20.73160140
75CDK140.72877231
76PNCK0.70025973
77ALK0.68658025
78MAPK130.67866657
79OXSR10.67405188
80CSNK1A1L0.66993124
81MINK10.66792294
82CDK180.66166208
83CLK10.65530332
84CDK11A0.64158813
85RPS6KB20.63305222
86ERBB40.60760318
87MYLK0.60120042
88CDK150.58952612
89PRKCI0.58767197
90STK38L0.58181852
91EPHA40.57783517
92CSNK1G20.55956863
93CDK20.55933873
94KSR10.54188881
95ATM0.53176606
96DAPK10.52810794
97DYRK1A0.52650605
98CDK90.52191651
99CDK10.51616374
100INSRR0.51248788
101ILK0.51074152
102MELK0.50438182
103CSNK1E0.46770606
104CDK60.46683100
105PRKCE0.45449541
106LATS10.45327460
107PIM20.44879225
108CAMK2B0.44607231
109PRKDC0.43820201
110PRKCG0.43730055
111EPHB20.42766515
112STK30.40385316
113EPHA30.40262704
114NTRK20.38944628
115FLT30.38399027
116RPS6KA50.38118862
117CSNK1D0.38068359
118WNK30.37467033
119MAPKAPK50.34893133
120FGFR10.34832621
121FER0.34159079
122PDK30.34118949
123PDK40.34118949
124MARK10.32241092
125ADRBK10.32118500
126MAP3K80.31875524
127PTK2B0.29474691
128CSNK1A10.28684801
129WNK40.28370193
130ABL20.28196956
131EIF2AK20.26793928

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.18398582
2RNA polymerase_Homo sapiens_hsa030204.11414624
3Ribosome_Homo sapiens_hsa030103.62620675
4DNA replication_Homo sapiens_hsa030303.48250757
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37959101
6* Spliceosome_Homo sapiens_hsa030403.18823184
7Mismatch repair_Homo sapiens_hsa034303.01121554
8* RNA transport_Homo sapiens_hsa030132.85946375
9Protein export_Homo sapiens_hsa030602.83772316
10Oxidative phosphorylation_Homo sapiens_hsa001902.65133429
11Nucleotide excision repair_Homo sapiens_hsa034202.50086649
12Homologous recombination_Homo sapiens_hsa034402.49392973
13Parkinsons disease_Homo sapiens_hsa050122.43724003
14Pyrimidine metabolism_Homo sapiens_hsa002402.36841010
15Cell cycle_Homo sapiens_hsa041102.31868696
16Basal transcription factors_Homo sapiens_hsa030222.24030386
17Base excision repair_Homo sapiens_hsa034102.13757899
18Huntingtons disease_Homo sapiens_hsa050162.05940780
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03538528
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87283837
21RNA degradation_Homo sapiens_hsa030181.82966744
22Propanoate metabolism_Homo sapiens_hsa006401.73962445
23Fanconi anemia pathway_Homo sapiens_hsa034601.69727200
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64782984
25Non-homologous end-joining_Homo sapiens_hsa034501.58246517
26Purine metabolism_Homo sapiens_hsa002301.56931318
27Selenocompound metabolism_Homo sapiens_hsa004501.53988279
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53251131
29Alzheimers disease_Homo sapiens_hsa050101.52104880
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48810222
31* mRNA surveillance pathway_Homo sapiens_hsa030151.47850734
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32772477
33Oocyte meiosis_Homo sapiens_hsa041141.25997221
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25803784
35Butanoate metabolism_Homo sapiens_hsa006501.21217145
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09610370
37Vitamin B6 metabolism_Homo sapiens_hsa007501.09275236
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06035771
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03503936
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00647483
41One carbon pool by folate_Homo sapiens_hsa006700.99555534
42Vibrio cholerae infection_Homo sapiens_hsa051100.97218333
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95952712
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95598227
45Epstein-Barr virus infection_Homo sapiens_hsa051690.95348860
46Fatty acid metabolism_Homo sapiens_hsa012120.94545797
47p53 signaling pathway_Homo sapiens_hsa041150.89178683
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86835283
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86609534
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84570568
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81916586
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.81151782
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76020689
54Sulfur relay system_Homo sapiens_hsa041220.75226491
55Collecting duct acid secretion_Homo sapiens_hsa049660.74417573
56Peroxisome_Homo sapiens_hsa041460.73244394
57Cardiac muscle contraction_Homo sapiens_hsa042600.72692782
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68411347
59N-Glycan biosynthesis_Homo sapiens_hsa005100.62157366
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59919624
61Regulation of autophagy_Homo sapiens_hsa041400.55307975
62Hippo signaling pathway_Homo sapiens_hsa043900.53962187
63Alcoholism_Homo sapiens_hsa050340.53150682
64Phototransduction_Homo sapiens_hsa047440.51878733
65Hedgehog signaling pathway_Homo sapiens_hsa043400.51075984
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50610855
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49538630
68TGF-beta signaling pathway_Homo sapiens_hsa043500.49082376
69Thyroid cancer_Homo sapiens_hsa052160.47903441
70Glutathione metabolism_Homo sapiens_hsa004800.47607951
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46852279
72Folate biosynthesis_Homo sapiens_hsa007900.46215059
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44258926
74Metabolic pathways_Homo sapiens_hsa011000.44237809
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40800931
76Basal cell carcinoma_Homo sapiens_hsa052170.38172034
77GABAergic synapse_Homo sapiens_hsa047270.37479687
78Systemic lupus erythematosus_Homo sapiens_hsa053220.36554534
79Synaptic vesicle cycle_Homo sapiens_hsa047210.35133167
80Biosynthesis of amino acids_Homo sapiens_hsa012300.35109991
81beta-Alanine metabolism_Homo sapiens_hsa004100.35096769
82Sulfur metabolism_Homo sapiens_hsa009200.33261365
83Wnt signaling pathway_Homo sapiens_hsa043100.33016357
84Pentose phosphate pathway_Homo sapiens_hsa000300.32792062
85Viral carcinogenesis_Homo sapiens_hsa052030.31787676
86Tight junction_Homo sapiens_hsa045300.27036695
87Fatty acid elongation_Homo sapiens_hsa000620.26301467
88Arachidonic acid metabolism_Homo sapiens_hsa005900.25957889
89HTLV-I infection_Homo sapiens_hsa051660.24938634
90Carbon metabolism_Homo sapiens_hsa012000.23832974
91Ether lipid metabolism_Homo sapiens_hsa005650.22593744
92Sphingolipid metabolism_Homo sapiens_hsa006000.21949837
93Fructose and mannose metabolism_Homo sapiens_hsa000510.21762214
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21477899
95Fatty acid degradation_Homo sapiens_hsa000710.20970511
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.19943832
97Serotonergic synapse_Homo sapiens_hsa047260.19293980
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18516911
99Bladder cancer_Homo sapiens_hsa052190.18513703
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16976449
101Circadian rhythm_Homo sapiens_hsa047100.16272700
102Colorectal cancer_Homo sapiens_hsa052100.15952768
103Dopaminergic synapse_Homo sapiens_hsa047280.15832477
104Adherens junction_Homo sapiens_hsa045200.15541447
105Amphetamine addiction_Homo sapiens_hsa050310.15482456
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.14721371
107Steroid biosynthesis_Homo sapiens_hsa001000.14623564
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14460409
109Phagosome_Homo sapiens_hsa041450.14381526
110Axon guidance_Homo sapiens_hsa043600.12694429
111Lysine degradation_Homo sapiens_hsa003100.12533232
112Linoleic acid metabolism_Homo sapiens_hsa005910.12363469
113Nicotine addiction_Homo sapiens_hsa050330.12190427
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11445477
115Pyruvate metabolism_Homo sapiens_hsa006200.11168173
116Taste transduction_Homo sapiens_hsa047420.11052776
117Shigellosis_Homo sapiens_hsa051310.10931075
118MicroRNAs in cancer_Homo sapiens_hsa052060.10175891
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09298478
120Melanoma_Homo sapiens_hsa052180.09199179
121Arginine and proline metabolism_Homo sapiens_hsa003300.08951707
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.06029163
123Galactose metabolism_Homo sapiens_hsa000520.05239280

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