NCBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of axon extension involved in axon guidance (GO:0048843)4.91605476
2axon extension involved in axon guidance (GO:0048846)4.90428604
3neuron projection extension involved in neuron projection guidance (GO:1902284)4.90428604
4ganglion development (GO:0061548)4.60971109
5negative regulation of axon guidance (GO:1902668)4.60601701
6cell proliferation in forebrain (GO:0021846)4.44939432
7behavioral response to nicotine (GO:0035095)4.40978509
8facial nerve structural organization (GO:0021612)4.39503807
9cytoplasmic mRNA processing body assembly (GO:0033962)4.16695429
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.15765030
11nuclear pore complex assembly (GO:0051292)3.85271604
12positive regulation of developmental pigmentation (GO:0048087)3.81719159
13kinetochore organization (GO:0051383)3.77333066
14nuclear pore organization (GO:0006999)3.71629207
15kidney morphogenesis (GO:0060993)3.71328352
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.70048052
17regulation of pigment cell differentiation (GO:0050932)3.64814757
18cilium or flagellum-dependent cell motility (GO:0001539)3.60162370
19regulation of nuclear cell cycle DNA replication (GO:0033262)3.58131169
20cranial nerve structural organization (GO:0021604)3.57546789
21kinetochore assembly (GO:0051382)3.55936548
22mRNA splice site selection (GO:0006376)3.38338537
23positive regulation by host of viral transcription (GO:0043923)3.36189292
24ribosomal large subunit biogenesis (GO:0042273)3.35821754
25neural tube formation (GO:0001841)3.27654710
26tongue development (GO:0043586)3.25414172
27pre-miRNA processing (GO:0031054)3.21744195
28pore complex assembly (GO:0046931)3.20673480
29regulation of gene silencing by RNA (GO:0060966)3.20355066
30regulation of posttranscriptional gene silencing (GO:0060147)3.20355066
31regulation of gene silencing by miRNA (GO:0060964)3.20355066
32microtubule depolymerization (GO:0007019)3.19094402
33negative regulation of histone methylation (GO:0031061)3.16627455
34motile cilium assembly (GO:0044458)3.14576125
35regulation of DNA endoreduplication (GO:0032875)3.14223555
36mitotic sister chromatid cohesion (GO:0007064)3.13999228
37regulation of axon guidance (GO:1902667)3.13999184
38regulation of axon extension involved in axon guidance (GO:0048841)3.13054447
39cilium movement (GO:0003341)3.09860502
40meiotic chromosome segregation (GO:0045132)3.09315040
41interkinetic nuclear migration (GO:0022027)3.07672227
42snRNA transcription (GO:0009301)3.07657996
43arginine catabolic process (GO:0006527)3.06822953
44telomere maintenance via semi-conservative replication (GO:0032201)3.05920061
45monoubiquitinated protein deubiquitination (GO:0035520)3.05553088
46pyrimidine nucleobase catabolic process (GO:0006208)3.05072077
47CENP-A containing nucleosome assembly (GO:0034080)3.04628480
48regulation of telomere maintenance via telomerase (GO:0032210)3.04574951
49protein K6-linked ubiquitination (GO:0085020)3.01691650
50cranial nerve morphogenesis (GO:0021602)3.01384745
51brain morphogenesis (GO:0048854)2.99875536
52chromatin remodeling at centromere (GO:0031055)2.99336483
53histone lysine methylation (GO:0034968)2.94720737
54DNA replication checkpoint (GO:0000076)2.94606892
55DNA replication initiation (GO:0006270)2.93583864
56telomere maintenance via telomerase (GO:0007004)2.91880676
57negative regulation of Rho protein signal transduction (GO:0035024)2.89753039
58telomere maintenance via recombination (GO:0000722)2.88468892
59proline transport (GO:0015824)2.88280339
60axonemal dynein complex assembly (GO:0070286)2.87627578
61telomere maintenance via telomere lengthening (GO:0010833)2.87247897
62epithelial cilium movement (GO:0003351)2.85904425
63mitotic recombination (GO:0006312)2.85762125
64negative chemotaxis (GO:0050919)2.84007665
65cerebral cortex radially oriented cell migration (GO:0021799)2.79830896
66DNA strand renaturation (GO:0000733)2.79304904
67neuronal stem cell maintenance (GO:0097150)2.79186237
68spinal cord motor neuron differentiation (GO:0021522)2.78536817
69mitotic metaphase plate congression (GO:0007080)2.78268815
70DNA strand elongation involved in DNA replication (GO:0006271)2.78132896
71DNA replication-independent nucleosome assembly (GO:0006336)2.75993304
72DNA replication-independent nucleosome organization (GO:0034724)2.75993304
73protein localization to kinetochore (GO:0034501)2.74237258
74regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74014093
75positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74014093
76mismatch repair (GO:0006298)2.72204801
77N-terminal protein amino acid acetylation (GO:0006474)2.72153070
78DNA strand elongation (GO:0022616)2.71167454
79lung-associated mesenchyme development (GO:0060484)2.69701334
80histone H3-K9 modification (GO:0061647)2.69534796
81artery development (GO:0060840)2.69102690
82cardiovascular system development (GO:0072358)2.68151929
83metaphase plate congression (GO:0051310)2.67968412
84rRNA catabolic process (GO:0016075)2.67201186
85establishment of protein localization to Golgi (GO:0072600)2.66742634
86camera-type eye morphogenesis (GO:0048593)2.66638471
87ribosomal small subunit biogenesis (GO:0042274)2.66389021
88positive regulation of histone H3-K4 methylation (GO:0051571)2.65742058
89anatomical structure arrangement (GO:0048532)2.65219310
90fucose catabolic process (GO:0019317)2.64679470
91L-fucose metabolic process (GO:0042354)2.64679470
92L-fucose catabolic process (GO:0042355)2.64679470
93DNA unwinding involved in DNA replication (GO:0006268)2.64648826
94peptidyl-lysine methylation (GO:0018022)2.64614456
95spindle checkpoint (GO:0031577)2.62192863
96positive regulation of action potential (GO:0045760)2.61820606
97olfactory bulb development (GO:0021772)2.61439180
98DNA synthesis involved in DNA repair (GO:0000731)2.61149940
99collecting duct development (GO:0072044)2.60920613
100phospholipid translocation (GO:0045332)2.59747851
101lipid translocation (GO:0034204)2.59747851
102microtubule anchoring (GO:0034453)2.59324914
103telomere maintenance (GO:0000723)2.59276662
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.59116595
105regulation of helicase activity (GO:0051095)2.58550454
106activated T cell proliferation (GO:0050798)2.57447983
107nonmotile primary cilium assembly (GO:0035058)2.56724886
108centriole replication (GO:0007099)2.56394170
109negative regulation of translation, ncRNA-mediated (GO:0040033)2.55550173
110regulation of translation, ncRNA-mediated (GO:0045974)2.55550173
111negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55550173
112telomere organization (GO:0032200)2.55532614
113head development (GO:0060322)2.54999576
114centriole assembly (GO:0098534)2.53980168
115establishment of chromosome localization (GO:0051303)2.53713835
116sister chromatid cohesion (GO:0007062)2.53701404
117ribosomal small subunit assembly (GO:0000028)2.53555138
118radial glial cell differentiation (GO:0060019)2.53401149
119regulation of hippo signaling (GO:0035330)2.53367092
120maturation of SSU-rRNA (GO:0030490)2.51928549
121axoneme assembly (GO:0035082)2.51593925
122viral transcription (GO:0019083)2.51437423
123regulation of histone H3-K9 methylation (GO:0051570)2.51367385
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.50477717
125histone H3-K9 methylation (GO:0051567)2.50150232
126protein localization to chromosome, centromeric region (GO:0071459)2.49925069
127microtubule polymerization or depolymerization (GO:0031109)2.48420638
128mitotic spindle checkpoint (GO:0071174)2.48329619
129RNA-dependent DNA replication (GO:0006278)2.48223819
130spindle assembly checkpoint (GO:0071173)2.46305785
131regulation of telomere maintenance (GO:0032204)2.45899473
132protein localization to microtubule cytoskeleton (GO:0072698)2.45767930
133regulation of cilium movement (GO:0003352)2.45545336
134V(D)J recombination (GO:0033151)2.45451679
135DNA alkylation (GO:0006305)2.45433115
136DNA methylation (GO:0006306)2.45433115
137regulation of histone H3-K4 methylation (GO:0051569)2.44823550
138hindbrain development (GO:0030902)2.44623054
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44528780
140nucleobase catabolic process (GO:0046113)2.44112495
141DNA ligation (GO:0006266)2.44032435
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.43980152
143histone H3-K4 trimethylation (GO:0080182)2.43884388
144translational termination (GO:0006415)2.42727845
145histone exchange (GO:0043486)2.42496701
146positive regulation of gene expression, epigenetic (GO:0045815)2.41122193
147DNA integration (GO:0015074)2.41057692
148DNA geometric change (GO:0032392)2.41006029
149positive regulation of mRNA catabolic process (GO:0061014)2.40686618
150regulation of DNA damage checkpoint (GO:2000001)2.40358735
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.40106808
152negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40106808
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40106808
154negative regulation of sister chromatid segregation (GO:0033046)2.40106808
155ATP-dependent chromatin remodeling (GO:0043044)2.39776960
156DNA duplex unwinding (GO:0032508)2.39747651
157appendage development (GO:0048736)2.39732630
158limb development (GO:0060173)2.39732630
159cerebral cortex neuron differentiation (GO:0021895)2.39467945
160DNA-dependent DNA replication (GO:0006261)2.38881681
161mitotic nuclear envelope disassembly (GO:0007077)2.38212413
162replicative senescence (GO:0090399)2.37810437
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37518839
164regulation of mitotic spindle checkpoint (GO:1903504)2.37518839
165regulation of spindle organization (GO:0090224)2.36690221
166DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36580764
167negative regulation of chromosome segregation (GO:0051985)2.36558120
168mitotic spindle assembly checkpoint (GO:0007094)2.36273061
169peptidyl-lysine trimethylation (GO:0018023)2.34902974
170sister chromatid segregation (GO:0000819)2.34213243
171regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33346817
172negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.31840585
173regulation of mitotic metaphase/anaphase transition (GO:0030071)2.31238476
174attachment of spindle microtubules to kinetochore (GO:0008608)2.29931430
175intra-S DNA damage checkpoint (GO:0031573)2.29379846
176histone H3-K4 methylation (GO:0051568)2.29099047
177reciprocal DNA recombination (GO:0035825)2.27404292
178reciprocal meiotic recombination (GO:0007131)2.27404292
179mitotic G2/M transition checkpoint (GO:0044818)2.27333373
180mitotic sister chromatid segregation (GO:0000070)2.26829929
181protein localization to chromosome (GO:0034502)2.26601658
182regulation of centriole replication (GO:0046599)2.26584313
183histone H3-K36 demethylation (GO:0070544)2.26319642
184regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.25052493
185DNA topological change (GO:0006265)2.24744806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.65686920
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.05754766
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.23912026
4EZH2_22144423_ChIP-Seq_EOC_Human4.10899549
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.45736406
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33260476
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.20919300
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.56418142
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54988880
10ZNF274_21170338_ChIP-Seq_K562_Hela2.51723352
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47342352
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44300934
13VDR_22108803_ChIP-Seq_LS180_Human2.32757409
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.32246365
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29774514
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26217992
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24942526
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17275847
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16813281
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.11991828
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07931882
22TAF15_26573619_Chip-Seq_HEK293_Human2.07107054
23GBX2_23144817_ChIP-Seq_PC3_Human2.05478474
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.03287264
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00732566
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00490547
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.97933089
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91828128
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91828128
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91051240
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.88186400
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.86603665
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82982516
34ELK1_19687146_ChIP-ChIP_HELA_Human1.82005936
35VDR_23849224_ChIP-Seq_CD4+_Human1.81307963
36DROSHA_22980978_ChIP-Seq_HELA_Human1.81093175
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80880192
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80475026
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79298415
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74638562
41FOXP3_21729870_ChIP-Seq_TREG_Human1.74604013
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74477442
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72042926
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71726678
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70979800
46STAT3_23295773_ChIP-Seq_U87_Human1.69500448
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.69268035
48AR_21572438_ChIP-Seq_LNCaP_Human1.68907226
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68076001
50BCAT_22108803_ChIP-Seq_LS180_Human1.67037307
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66946518
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.66588965
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.65028222
54REST_21632747_ChIP-Seq_MESCs_Mouse1.64477712
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59636871
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57300686
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56300776
58CIITA_25753668_ChIP-Seq_RAJI_Human1.56225363
59TCF4_23295773_ChIP-Seq_U87_Human1.54675642
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54236502
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53523931
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.53377175
63CBP_20019798_ChIP-Seq_JUKART_Human1.50818856
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50818856
65TTF2_22483619_ChIP-Seq_HELA_Human1.48746797
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47782557
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.45276491
68ER_23166858_ChIP-Seq_MCF-7_Human1.45216337
69RUNX2_22187159_ChIP-Seq_PCA_Human1.44352747
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43691075
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43274138
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42376123
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41257361
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.40866678
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38880472
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38879357
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38635072
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37500657
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36261929
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36224412
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35833628
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34923142
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34010540
84RNF2_27304074_Chip-Seq_NSC_Mouse1.33560564
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31334115
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31180139
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30907213
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30484451
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30394617
90AHR_22903824_ChIP-Seq_MCF-7_Human1.30225562
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30059218
92P300_19829295_ChIP-Seq_ESCs_Human1.29159849
93SMAD4_21799915_ChIP-Seq_A2780_Human1.28742208
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.28311084
95E2F1_17053090_ChIP-ChIP_MCF-7_Human1.27749666
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.27311698
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27220410
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.26762095
99TP53_16413492_ChIP-PET_HCT116_Human1.26747932
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26226598
101XRN2_22483619_ChIP-Seq_HELA_Human1.26225355
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23450553
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23007281
104FUS_26573619_Chip-Seq_HEK293_Human1.22882262
105AR_21909140_ChIP-Seq_LNCAP_Human1.22400252
106TCF4_22108803_ChIP-Seq_LS180_Human1.22301337
107EWS_26573619_Chip-Seq_HEK293_Human1.21865556
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20612485
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18391307
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17882373
111MYC_18940864_ChIP-ChIP_HL60_Human1.17704095
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16897713
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.16417808
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16379693
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15918417
116RXR_22108803_ChIP-Seq_LS180_Human1.15250811
117AR_19668381_ChIP-Seq_PC3_Human1.15024567
118PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12530222
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11362893
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10625218
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10610095
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.08970459
123AR_25329375_ChIP-Seq_VCAP_Human1.08714647
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08570359
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07060165
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.06760708
127DCP1A_22483619_ChIP-Seq_HELA_Human1.06066981
128HOXB7_26014856_ChIP-Seq_BT474_Human1.05963433
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.05708512
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.05519807
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05123487
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05123487
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05123487
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04111183
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03390723
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03379542
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03091051
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.03085438
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02845417
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02126732
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01509788
142TP63_17297297_ChIP-ChIP_HaCaT_Human0.99724571
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97563322
144IRF1_19129219_ChIP-ChIP_H3396_Human0.96669226
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96334447
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96274773
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96116075
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94681883
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94507670
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.93949030
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93827634
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.92774980
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92552940
154RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92552940
155CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91657073
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91091160
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90852340
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90720662
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.90710768
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90392545
161ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90206292
162NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90187751
163POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89688917
164ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87959105
165FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87690215
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87315292
167RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86491888
168E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85817829
169SPI1_23547873_ChIP-Seq_NB4_Human0.84915448
170THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83625134
171POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83178462
172E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82957124
173E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82290947
174KDM5A_27292631_Chip-Seq_BREAST_Human0.81653487
175IGF1R_20145208_ChIP-Seq_DFB_Human0.80104057
176GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79004969
177SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78548605
178EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78410305
179MYB_26560356_Chip-Seq_TH1_Human0.78295163
180MYB_26560356_Chip-Seq_TH2_Human0.78266512
181SOX2_16153702_ChIP-ChIP_HESCs_Human0.78130279
182FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77939559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.51589618
2MP0003111_abnormal_nucleus_morphology3.19204874
3MP0008057_abnormal_DNA_replication3.15970633
4MP0010094_abnormal_chromosome_stability3.08302672
5MP0003693_abnormal_embryo_hatching2.99759235
6MP0008058_abnormal_DNA_repair2.71558319
7MP0004381_abnormal_hair_follicle2.53155367
8MP0003077_abnormal_cell_cycle2.48754505
9MP0001188_hyperpigmentation2.48538052
10MP0000778_abnormal_nervous_system2.44054760
11MP0006292_abnormal_olfactory_placode2.23596520
12MP0002102_abnormal_ear_morphology2.20907627
13MP0008007_abnormal_cellular_replicative2.19233104
14MP0003941_abnormal_skin_development2.19111644
15MP0003136_yellow_coat_color2.16309290
16MP0000631_abnormal_neuroendocrine_gland2.16103966
17MP0005499_abnormal_olfactory_system2.01313518
18MP0005394_taste/olfaction_phenotype2.01313518
19MP0005409_darkened_coat_color1.96750322
20MP0002396_abnormal_hematopoietic_system1.91909426
21MP0004133_heterotaxia1.88014023
22MP0000427_abnormal_hair_cycle1.85160308
23MP0002653_abnormal_ependyma_morphology1.80190691
24MP0008877_abnormal_DNA_methylation1.79742833
25MP0000569_abnormal_digit_pigmentation1.74310031
26MP0003646_muscle_fatigue1.73330165
27MP0010030_abnormal_orbit_morphology1.70046879
28MP0008932_abnormal_embryonic_tissue1.69958150
29MP0004957_abnormal_blastocyst_morpholog1.68108280
30MP0003763_abnormal_thymus_physiology1.65747967
31MP0005174_abnormal_tail_pigmentation1.65190594
32MP0000383_abnormal_hair_follicle1.64089706
33MP0000015_abnormal_ear_pigmentation1.62841367
34MP0002938_white_spotting1.59015629
35MP0003195_calcinosis1.56703702
36MP0002277_abnormal_respiratory_mucosa1.54311962
37MP0001293_anophthalmia1.52165185
38MP0002095_abnormal_skin_pigmentation1.46775503
39MP0000490_abnormal_crypts_of1.42244628
40MP0002009_preneoplasia1.40559188
41MP0003861_abnormal_nervous_system1.39169917
42MP0008961_abnormal_basal_metabolism1.38312088
43MP0002184_abnormal_innervation1.36733311
44MP0005377_hearing/vestibular/ear_phenot1.36126981
45MP0003878_abnormal_ear_physiology1.36126981
46MP0009053_abnormal_anal_canal1.33029799
47MP0000350_abnormal_cell_proliferation1.32043743
48MP0003786_premature_aging1.32040392
49MP0003121_genomic_imprinting1.27491302
50MP0003890_abnormal_embryonic-extraembry1.25335108
51MP0005075_abnormal_melanosome_morpholog1.20607217
52MP0005083_abnormal_biliary_tract1.19676360
53MP0003787_abnormal_imprinting1.19277531
54MP0005171_absent_coat_pigmentation1.18863572
55MP0003937_abnormal_limbs/digits/tail_de1.16976817
56MP0001348_abnormal_lacrimal_gland1.16233565
57MP0010307_abnormal_tumor_latency1.15146326
58MP0005248_abnormal_Harderian_gland1.14033169
59MP0006072_abnormal_retinal_apoptosis1.13549168
60MP0001986_abnormal_taste_sensitivity1.12235312
61MP0004924_abnormal_behavior1.11769163
62MP0005386_behavior/neurological_phenoty1.11769163
63MP0004808_abnormal_hematopoietic_stem1.11727276
64MP0000703_abnormal_thymus_morphology1.11125719
65MP0004043_abnormal_pH_regulation1.10736248
66MP0005646_abnormal_pituitary_gland1.08708670
67MP0002557_abnormal_social/conspecific_i1.07972813
68MP0003119_abnormal_digestive_system1.06899112
69MP0002928_abnormal_bile_duct1.05615838
70MP0001286_abnormal_eye_development1.04703209
71MP0009697_abnormal_copulation1.04158697
72MP0005671_abnormal_response_to1.03244222
73MP0010352_gastrointestinal_tract_polyps1.02813124
74MP0002152_abnormal_brain_morphology1.02796557
75MP0002075_abnormal_coat/hair_pigmentati1.02656745
76MP0008775_abnormal_heart_ventricle1.00503594
77MP0001186_pigmentation_phenotype1.00286892
78MP0005084_abnormal_gallbladder_morpholo0.99280193
79MP0002752_abnormal_somatic_nervous0.99051127
80MP0005391_vision/eye_phenotype0.98442177
81MP0002168_other_aberrant_phenotype0.98299999
82MP0000955_abnormal_spinal_cord0.97934340
83MP0003943_abnormal_hepatobiliary_system0.97177517
84MP0006276_abnormal_autonomic_nervous0.96864942
85MP0003938_abnormal_ear_development0.95388633
86MP0002116_abnormal_craniofacial_bone0.94744346
87MP0002398_abnormal_bone_marrow0.94015708
88MP0002233_abnormal_nose_morphology0.93913294
89MP0002098_abnormal_vibrissa_morphology0.93551062
90MP0005257_abnormal_intraocular_pressure0.92667791
91MP0003698_abnormal_male_reproductive0.92351434
92MP0008995_early_reproductive_senescence0.91976656
93MP0002085_abnormal_embryonic_tissue0.91848898
94MP0004130_abnormal_muscle_cell0.91549255
95MP0009333_abnormal_splenocyte_physiolog0.91496116
96MP0002210_abnormal_sex_determination0.91262012
97MP0004142_abnormal_muscle_tone0.90634471
98MP0000372_irregular_coat_pigmentation0.90528058
99MP0005253_abnormal_eye_physiology0.90035720
100MP0005551_abnormal_eye_electrophysiolog0.89776205
101MP0001346_abnormal_lacrimal_gland0.89610817
102MP0000049_abnormal_middle_ear0.89548707
103MP0010678_abnormal_skin_adnexa0.89298682
104MP0002092_abnormal_eye_morphology0.89255258
105MP0004742_abnormal_vestibular_system0.89057451
106MP0001800_abnormal_humoral_immune0.88886968
107MP0002882_abnormal_neuron_morphology0.88867186
108MP0009046_muscle_twitch0.88841754
109MP0001672_abnormal_embryogenesis/_devel0.88720653
110MP0005380_embryogenesis_phenotype0.88720653
111MP0002735_abnormal_chemical_nociception0.87986642
112MP0008770_decreased_survivor_rate0.87679437
113MP0001835_abnormal_antigen_presentation0.87636303
114MP0002751_abnormal_autonomic_nervous0.86735347
115MP0002063_abnormal_learning/memory/cond0.86671278
116MP0001984_abnormal_olfaction0.86617967
117MP0005195_abnormal_posterior_eye0.86603247
118MP0000313_abnormal_cell_death0.85878908
119MP0003283_abnormal_digestive_organ0.85812329
120MP0002160_abnormal_reproductive_system0.85426294
121MP0000377_abnormal_hair_follicle0.84266213
122MP0001485_abnormal_pinna_reflex0.84230529
123MP0000371_diluted_coat_color0.84146367
124MP0000647_abnormal_sebaceous_gland0.83360170
125MP0004197_abnormal_fetal_growth/weight/0.83015839
126MP0002638_abnormal_pupillary_reflex0.82546108
127MP0001730_embryonic_growth_arrest0.82170291
128MP0002019_abnormal_tumor_incidence0.82090179
129MP0003315_abnormal_perineum_morphology0.82080312
130MP0002177_abnormal_outer_ear0.81827871
131MP0002249_abnormal_larynx_morphology0.81724066
132MP0002084_abnormal_developmental_patter0.80778332
133MP0000432_abnormal_head_morphology0.80565758
134MP0002452_abnormal_antigen_presenting0.80559490
135MP0003755_abnormal_palate_morphology0.80546422
136MP0005423_abnormal_somatic_nervous0.80270449
137MP0002876_abnormal_thyroid_physiology0.79784207
138MP0003123_paternal_imprinting0.79331482
139MP0004811_abnormal_neuron_physiology0.78640375
140MP0002081_perinatal_lethality0.78374806
141MP0002722_abnormal_immune_system0.78332959
142MP0002088_abnormal_embryonic_growth/wei0.78253897
143MP0000428_abnormal_craniofacial_morphol0.78087328
144MP0001697_abnormal_embryo_size0.77856795
145MP0003935_abnormal_craniofacial_develop0.77261016
146MP0003635_abnormal_synaptic_transmissio0.77062186
147MP0005220_abnormal_exocrine_pancreas0.76803625
148MP0002006_tumorigenesis0.76589769
149MP0008789_abnormal_olfactory_epithelium0.76228034
150MP0002420_abnormal_adaptive_immunity0.74724531
151MP0003942_abnormal_urinary_system0.74634043
152MP0005076_abnormal_cell_differentiation0.73813987
153MP0001819_abnormal_immune_cell0.73585137
154MP0003718_maternal_effect0.73305316
155MP0003567_abnormal_fetal_cardiomyocyte0.72838240
156MP0001119_abnormal_female_reproductive0.72766781
157MP0000613_abnormal_salivary_gland0.71516902
158MP0003984_embryonic_growth_retardation0.71210970

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.03764548
2Chromsome breakage (HP:0040012)5.00736644
3Nephronophthisis (HP:0000090)4.23698875
4Abnormality of the renal medulla (HP:0100957)3.60311290
5Pancreatic cysts (HP:0001737)3.59942895
6Short 4th metacarpal (HP:0010044)3.54799112
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.54799112
8Reticulocytopenia (HP:0001896)3.50687225
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.48898995
10Absent/shortened dynein arms (HP:0200106)3.48898995
11Genetic anticipation (HP:0003743)3.44500938
12Pancreatic fibrosis (HP:0100732)3.44179260
13Duplicated collecting system (HP:0000081)3.29203783
14True hermaphroditism (HP:0010459)3.19180908
15Rib fusion (HP:0000902)3.16428135
16Abnormality of chromosome stability (HP:0003220)3.10877978
17Ectopic kidney (HP:0000086)3.07651645
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.05662853
19Abnormality of the preputium (HP:0100587)3.05488324
20Abnormality of the renal collecting system (HP:0004742)3.05039493
21Meckel diverticulum (HP:0002245)3.00273622
22Congenital stationary night blindness (HP:0007642)2.96052521
23Abnormal respiratory motile cilium morphology (HP:0005938)2.92836527
24Abnormal respiratory epithelium morphology (HP:0012253)2.92836527
25Molar tooth sign on MRI (HP:0002419)2.91771312
26Abnormality of midbrain morphology (HP:0002418)2.91771312
27High anterior hairline (HP:0009890)2.85010330
28Abnormality of the ileum (HP:0001549)2.84601276
29Chronic hepatic failure (HP:0100626)2.84243652
30Tubular atrophy (HP:0000092)2.78161963
31Abnormality of the 4th metacarpal (HP:0010012)2.74190021
32Protruding tongue (HP:0010808)2.72628874
33Abnormality of the aortic arch (HP:0012303)2.71195942
34Abnormal ciliary motility (HP:0012262)2.69909801
35Aplasia cutis congenita (HP:0001057)2.62971875
36Cystic liver disease (HP:0006706)2.62250957
37Abnormality of DNA repair (HP:0003254)2.62247282
38Duplication of thumb phalanx (HP:0009942)2.54208794
39Triphalangeal thumb (HP:0001199)2.48681266
40Absent radius (HP:0003974)2.47625209
41Abnormality of the nasal septum (HP:0000419)2.44322399
42Volvulus (HP:0002580)2.42288084
43Abnormal respiratory motile cilium physiology (HP:0012261)2.41408672
44Hyperventilation (HP:0002883)2.39807500
45Small intestinal stenosis (HP:0012848)2.36714717
46Duodenal stenosis (HP:0100867)2.36714717
47Poor coordination (HP:0002370)2.34475723
48Clubbing of toes (HP:0100760)2.33449941
49Trigonocephaly (HP:0000243)2.32821598
50Progressive cerebellar ataxia (HP:0002073)2.31819319
51Lip pit (HP:0100267)2.31407409
52Cerebellar dysplasia (HP:0007033)2.30763509
53Birth length less than 3rd percentile (HP:0003561)2.29720935
54Abnormality of the carotid arteries (HP:0005344)2.28955426
55Prostate neoplasm (HP:0100787)2.28826487
56Oligodactyly (HP:0012165)2.28677558
57Partial agenesis of the corpus callosum (HP:0001338)2.28485443
58Stomach cancer (HP:0012126)2.28198840
59Aplasia involving forearm bones (HP:0009822)2.28012629
60Absent forearm bone (HP:0003953)2.28012629
61Broad-based gait (HP:0002136)2.22759349
62Aplasia/Hypoplasia of the earlobes (HP:0009906)2.21918036
63Attenuation of retinal blood vessels (HP:0007843)2.19737509
64Gait imbalance (HP:0002141)2.18999762
65Abnormality of the fingertips (HP:0001211)2.17987154
66Oligodactyly (hands) (HP:0001180)2.15828981
67Medial flaring of the eyebrow (HP:0010747)2.15531516
68Lissencephaly (HP:0001339)2.15001069
69Anencephaly (HP:0002323)2.14065622
70Myelodysplasia (HP:0002863)2.13952391
71Type II lissencephaly (HP:0007260)2.13862792
72Congenital primary aphakia (HP:0007707)2.13790655
73Patellar aplasia (HP:0006443)2.13671420
74Medulloblastoma (HP:0002885)2.12738910
75Sclerocornea (HP:0000647)2.10386031
76Nephroblastoma (Wilms tumor) (HP:0002667)2.07420934
77Postaxial foot polydactyly (HP:0001830)2.06411949
78Absent thumb (HP:0009777)2.05489144
79Abnormality of the renal cortex (HP:0011035)2.05457710
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.05415904
81Highly arched eyebrow (HP:0002553)2.02378294
82Increased nuchal translucency (HP:0010880)2.00200663
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00057751
84Drooling (HP:0002307)1.98383294
85Anal stenosis (HP:0002025)1.98124774
86Aqueductal stenosis (HP:0002410)1.96741722
87Sloping forehead (HP:0000340)1.95041586
88Bony spicule pigmentary retinopathy (HP:0007737)1.94837011
89Abnormality of the duodenum (HP:0002246)1.94679210
90Anophthalmia (HP:0000528)1.94635357
91Fair hair (HP:0002286)1.94382464
92Aplasia/Hypoplasia of the patella (HP:0006498)1.93446783
93Hypoplastic iliac wings (HP:0002866)1.92222932
94Rhinitis (HP:0012384)1.92218271
95Septo-optic dysplasia (HP:0100842)1.91392491
96Preaxial hand polydactyly (HP:0001177)1.90841463
97Dandy-Walker malformation (HP:0001305)1.90469359
98Gaze-evoked nystagmus (HP:0000640)1.90391491
99Embryonal renal neoplasm (HP:0011794)1.90349315
100Nephrogenic diabetes insipidus (HP:0009806)1.89660823
101Abnormality of the incisor (HP:0000676)1.87514155
102Vaginal atresia (HP:0000148)1.87081329
103Broad thumb (HP:0011304)1.86590098
104Truncal obesity (HP:0001956)1.86498945
105Abnormal number of incisors (HP:0011064)1.85686544
106Congenital hepatic fibrosis (HP:0002612)1.85615325
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85409659
108Genital tract atresia (HP:0001827)1.84949364
109Pallor (HP:0000980)1.84307060
110Congenital sensorineural hearing impairment (HP:0008527)1.83568626
111Short thumb (HP:0009778)1.82733340
112Exotropia (HP:0000577)1.81993076
113Preaxial foot polydactyly (HP:0001841)1.81724482
114Rectal prolapse (HP:0002035)1.81485717
115Excessive salivation (HP:0003781)1.80439005
116Bone marrow hypocellularity (HP:0005528)1.80153648
117Facial hemangioma (HP:0000329)1.79303022
118Abnormality of the parathyroid morphology (HP:0011766)1.77668250
119Bile duct proliferation (HP:0001408)1.76334398
120Abnormal biliary tract physiology (HP:0012439)1.76334398
121Dyschromatopsia (HP:0007641)1.75981482
122Abnormal hair whorl (HP:0010721)1.75267498
123Abnormal rod and cone electroretinograms (HP:0008323)1.74218106
124Furrowed tongue (HP:0000221)1.74117766
125Renal dysplasia (HP:0000110)1.73960291
126Leiomyosarcoma (HP:0100243)1.73164575
127Uterine leiomyosarcoma (HP:0002891)1.73164575
128Abnormality of incisor morphology (HP:0011063)1.71836079
129Pendular nystagmus (HP:0012043)1.70834851
130Hepatoblastoma (HP:0002884)1.70812605
131Decreased central vision (HP:0007663)1.70395955
132Occipital encephalocele (HP:0002085)1.70359798
133T lymphocytopenia (HP:0005403)1.68206616
134Pachygyria (HP:0001302)1.67809638
135Holoprosencephaly (HP:0001360)1.66809110
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66601548
137Severe visual impairment (HP:0001141)1.66387606
138Nasolacrimal duct obstruction (HP:0000579)1.66053733
139Optic nerve coloboma (HP:0000588)1.65964666
140Polydipsia (HP:0001959)1.65809958
141Abnormal drinking behavior (HP:0030082)1.65809958
142Neoplasm of the adrenal cortex (HP:0100641)1.65203116
143Upper limb muscle weakness (HP:0003484)1.65192939
144Lymphoma (HP:0002665)1.65069106
145Broad phalanges of the hand (HP:0009768)1.64718110
146Long eyelashes (HP:0000527)1.64501685
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64322935
148Widely spaced teeth (HP:0000687)1.64053764
149Supernumerary bones of the axial skeleton (HP:0009144)1.64044232
150Abnormality of the diencephalon (HP:0010662)1.63514179
151Clumsiness (HP:0002312)1.62674556
152Renal agenesis (HP:0000104)1.62588931
153Breast hypoplasia (HP:0003187)1.62556703
154Partial duplication of thumb phalanx (HP:0009944)1.62423845
155Overfolded helix (HP:0000396)1.62177440
156Supernumerary spleens (HP:0009799)1.61500592
157Colon cancer (HP:0003003)1.61235190
158Abnormality of the columella (HP:0009929)1.60136525
159Impulsivity (HP:0100710)1.60081503
160Prominent nose (HP:0000448)1.57721976
161Tracheoesophageal fistula (HP:0002575)1.57430793
162Intestinal atresia (HP:0011100)1.56266733
163Increased number of teeth (HP:0011069)1.55830035
164Abnormal sex determination (HP:0012244)1.55818970
165Sex reversal (HP:0012245)1.55818970
166Leukopenia (HP:0001882)1.55640199
167Abnormal lung lobation (HP:0002101)1.55533195
168Tubulointerstitial nephritis (HP:0001970)1.55228331
169Premature graying of hair (HP:0002216)1.54799576
170Abnormality of T cell number (HP:0011839)1.54745599
171Sparse scalp hair (HP:0002209)1.54040049
172Abnormality of the labia minora (HP:0012880)1.53888582
173Deep philtrum (HP:0002002)1.53351301
174Agnosia (HP:0010524)1.53183008
17511 pairs of ribs (HP:0000878)1.52671973
176Proximal placement of thumb (HP:0009623)1.52334840
177Retrobulbar optic neuritis (HP:0100654)1.51718912
178Optic neuritis (HP:0100653)1.51718912
179Conical tooth (HP:0000698)1.50952910
180Abnormality of the septum pellucidum (HP:0007375)1.50921753
181Transitional cell carcinoma of the bladder (HP:0006740)1.50101255
182Malignant gastrointestinal tract tumors (HP:0006749)1.48165309
183Gastrointestinal carcinoma (HP:0002672)1.48165309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR23.81099312
2BUB13.14438180
3ZAK3.04363140
4SRPK12.94222741
5TYRO32.74721341
6CDC72.70251807
7PLK42.65855675
8CDK122.58754150
9TXK2.41020566
10CAMK1G2.35235071
11IRAK32.20442628
12MKNK22.15148634
13TLK12.11308107
14CAMK1D2.09401844
15BRD42.06999723
16TTK2.02609939
17PNCK2.00717444
18NUAK11.98548025
19MAP3K41.95220241
20NTRK21.94999689
21PBK1.85247573
22MKNK11.82979932
23NEK21.81648297
24WNK41.81090059
25IRAK41.77223408
26VRK11.69032211
27ATR1.62742812
28YES11.60966989
29EIF2AK21.59730078
30WNK11.55144222
31STK161.55122173
32PASK1.53358684
33WEE11.45206172
34STK31.44615197
35FGFR41.39167920
36WNK31.38405631
37STK41.36923484
38RPS6KB21.36659556
39PLK11.35263605
40ICK1.34611173
41STK111.34568040
42INSRR1.33486665
43DYRK31.31309444
44CDK71.30228057
45CHEK21.30130644
46CDK81.29855402
47LATS11.28286585
48IRAK21.24869342
49AURKB1.24854174
50SGK21.23445549
51PLK31.22646079
52STK101.22432605
53SIK21.20168169
54NLK1.19908411
55MARK11.17893254
56IRAK11.16564579
57CLK11.11853243
58MAP3K61.11413709
59CDK91.10067383
60RPS6KA41.09802903
61MAPK151.07998435
62CHEK11.07801409
63BMPR1B1.06106786
64GRK11.05461633
65ATM1.05387218
66PINK11.03213483
67TNIK1.01252023
68TEC0.99898905
69FGFR30.99402247
70MAP2K70.99163852
71MAP4K10.98758714
72SGK2230.97869013
73SGK4940.97869013
74PIM10.97119452
75MELK0.96467849
76MAP3K70.95480592
77RPS6KA50.94022009
78MAP3K140.93555650
79STK38L0.93516500
80MARK20.93155236
81STK240.92746793
82EIF2AK30.89107092
83PIK3CA0.88676098
84BCR0.87564689
85RET0.87328492
86MAP2K40.86974034
87TRPM70.86424798
88CDK30.82633769
89OXSR10.82589092
90STK390.80761233
91TAF10.77243915
92CDK40.76294693
93EPHA20.75922120
94EIF2AK10.75736045
95CHUK0.75245005
96PDGFRB0.75180443
97EEF2K0.74863585
98MST40.73723468
99CAMK40.73559857
100MAPK130.73034369
101CASK0.72603959
102KSR10.69679585
103BRSK20.68392394
104ADRBK20.66384451
105ERBB30.66157605
106TNK20.65930168
107DYRK20.65883413
108NEK60.64834264
109CDK20.64150687
110RPS6KA60.63583010
111TSSK60.63528546
112MTOR0.62482736
113NTRK30.61816524
114ITK0.61755409
115AKT30.60905545
116CDK10.59910365
117AURKA0.58500994
118IKBKB0.58306976
119DYRK1A0.55563077
120EPHA30.55345401
121RPS6KA20.54724363
122FGFR10.54404584
123CDK190.53933315
124SGK30.53908031
125BTK0.52235611
126CDK60.50265490
127ACVR1B0.49890094
128TAOK30.48683397
129TGFBR10.47304517
130PAK30.47074241
131IKBKE0.46983122
132ADRBK10.46681842
133PRKAA20.46576777
134CAMK10.45654723
135CSNK1E0.45001512
136SGK10.44925122
137MAP3K100.44783703
138PRKAA10.44221789
139LCK0.43225931
140GSK3B0.42121297
141NEK90.41955092
142PRKD20.41205443
143TGFBR20.40965429
144PRKCZ0.40916709
145HIPK20.40853748
146JAK30.40819523
147PRKCH0.39259294
148CSNK2A20.39049221
149CSNK2A10.38862963
150FLT30.38526493
151TYK20.38333552
152MARK30.38087979
153AKT10.38050891
154MAPK140.37605337
155CSNK1A1L0.37536853
156LYN0.36347259
157CSNK1D0.36146466
158FRK0.35786178
159PRKDC0.35257709

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.17638287
2Fanconi anemia pathway_Homo sapiens_hsa034603.08648211
3Mismatch repair_Homo sapiens_hsa034302.91689327
4Homologous recombination_Homo sapiens_hsa034402.89916400
5Non-homologous end-joining_Homo sapiens_hsa034502.46267861
6Spliceosome_Homo sapiens_hsa030402.43914030
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38946980
8Ribosome_Homo sapiens_hsa030102.32228956
9Base excision repair_Homo sapiens_hsa034102.24481331
10Cell cycle_Homo sapiens_hsa041102.19261658
11RNA polymerase_Homo sapiens_hsa030202.17485510
12Nicotine addiction_Homo sapiens_hsa050332.12676496
13Nucleotide excision repair_Homo sapiens_hsa034202.08958446
14Basal transcription factors_Homo sapiens_hsa030222.02259437
15RNA transport_Homo sapiens_hsa030131.87616390
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74312222
17RNA degradation_Homo sapiens_hsa030181.72487230
18Linoleic acid metabolism_Homo sapiens_hsa005911.71567172
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68338924
20Phototransduction_Homo sapiens_hsa047441.68063095
21ABC transporters_Homo sapiens_hsa020101.66377560
22mRNA surveillance pathway_Homo sapiens_hsa030151.66048599
23Axon guidance_Homo sapiens_hsa043601.63101939
24One carbon pool by folate_Homo sapiens_hsa006701.61536603
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61334266
26p53 signaling pathway_Homo sapiens_hsa041151.56060451
27Olfactory transduction_Homo sapiens_hsa047401.55379672
28Primary immunodeficiency_Homo sapiens_hsa053401.53586409
29Systemic lupus erythematosus_Homo sapiens_hsa053221.51693810
30Taste transduction_Homo sapiens_hsa047421.43285748
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42526879
32Pyrimidine metabolism_Homo sapiens_hsa002401.42415203
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40282574
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.38141441
35Herpes simplex infection_Homo sapiens_hsa051681.37688207
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35422682
37Choline metabolism in cancer_Homo sapiens_hsa052311.34697862
38Dorso-ventral axis formation_Homo sapiens_hsa043201.34230264
39Morphine addiction_Homo sapiens_hsa050321.26277355
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.23700877
41Selenocompound metabolism_Homo sapiens_hsa004501.20279154
42Basal cell carcinoma_Homo sapiens_hsa052171.17909694
43Autoimmune thyroid disease_Homo sapiens_hsa053201.17568286
44Measles_Homo sapiens_hsa051621.17097016
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16200422
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13684839
47Hematopoietic cell lineage_Homo sapiens_hsa046401.13079899
48Glutamatergic synapse_Homo sapiens_hsa047241.12534786
49MicroRNAs in cancer_Homo sapiens_hsa052061.11157749
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10248823
51Notch signaling pathway_Homo sapiens_hsa043301.09451018
52Viral carcinogenesis_Homo sapiens_hsa052031.06827785
53Ovarian steroidogenesis_Homo sapiens_hsa049131.06428417
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05541553
55Epstein-Barr virus infection_Homo sapiens_hsa051691.02632923
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02414354
57Cholinergic synapse_Homo sapiens_hsa047250.98039243
58Nitrogen metabolism_Homo sapiens_hsa009100.97255564
59HTLV-I infection_Homo sapiens_hsa051660.97182725
60Circadian entrainment_Homo sapiens_hsa047130.96700575
61Melanogenesis_Homo sapiens_hsa049160.96351694
62Serotonergic synapse_Homo sapiens_hsa047260.93096094
63Type II diabetes mellitus_Homo sapiens_hsa049300.92859608
64Long-term depression_Homo sapiens_hsa047300.92733285
65Graft-versus-host disease_Homo sapiens_hsa053320.91938632
66GABAergic synapse_Homo sapiens_hsa047270.90776078
67Antigen processing and presentation_Homo sapiens_hsa046120.90641660
68Purine metabolism_Homo sapiens_hsa002300.89796151
69Allograft rejection_Homo sapiens_hsa053300.89647696
70Cocaine addiction_Homo sapiens_hsa050300.89452822
71cAMP signaling pathway_Homo sapiens_hsa040240.87721001
72Protein export_Homo sapiens_hsa030600.87661257
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86567656
74Small cell lung cancer_Homo sapiens_hsa052220.86276088
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86065700
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.84530343
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84259358
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81169847
79T cell receptor signaling pathway_Homo sapiens_hsa046600.81129501
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80844172
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79976604
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.79035695
83Ras signaling pathway_Homo sapiens_hsa040140.77556436
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77438127
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.77374924
86Sphingolipid metabolism_Homo sapiens_hsa006000.76360025
87Prostate cancer_Homo sapiens_hsa052150.75564210
88Butanoate metabolism_Homo sapiens_hsa006500.75241669
89ErbB signaling pathway_Homo sapiens_hsa040120.74840365
90Glycerolipid metabolism_Homo sapiens_hsa005610.73323592
91Hedgehog signaling pathway_Homo sapiens_hsa043400.73200977
92Hepatitis B_Homo sapiens_hsa051610.72345428
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.72267795
94Insulin secretion_Homo sapiens_hsa049110.71494714
95MAPK signaling pathway_Homo sapiens_hsa040100.71390954
96Apoptosis_Homo sapiens_hsa042100.70747222
97Oxytocin signaling pathway_Homo sapiens_hsa049210.69311435
98Calcium signaling pathway_Homo sapiens_hsa040200.68192646
99Colorectal cancer_Homo sapiens_hsa052100.67414080
100Dopaminergic synapse_Homo sapiens_hsa047280.66099072
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.65895961
102Wnt signaling pathway_Homo sapiens_hsa043100.65323207
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64768090
104VEGF signaling pathway_Homo sapiens_hsa043700.64671485
105Pathways in cancer_Homo sapiens_hsa052000.63954017
106Non-small cell lung cancer_Homo sapiens_hsa052230.63254897
107Alcoholism_Homo sapiens_hsa050340.62985055
108Lysine degradation_Homo sapiens_hsa003100.62802317
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62243503
110Asthma_Homo sapiens_hsa053100.62078070
111Proteasome_Homo sapiens_hsa030500.61460324
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61343953
113Adherens junction_Homo sapiens_hsa045200.60225059
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59750941
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.59447124
116Influenza A_Homo sapiens_hsa051640.59104403
117mTOR signaling pathway_Homo sapiens_hsa041500.58933176
118Prolactin signaling pathway_Homo sapiens_hsa049170.58682950
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57193277
120Chronic myeloid leukemia_Homo sapiens_hsa052200.55506371
121Hippo signaling pathway_Homo sapiens_hsa043900.55136444
122AMPK signaling pathway_Homo sapiens_hsa041520.53922719
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53144587
124Regulation of autophagy_Homo sapiens_hsa041400.53069073
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52957716
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52564282
127TGF-beta signaling pathway_Homo sapiens_hsa043500.52483387
128Insulin resistance_Homo sapiens_hsa049310.52196612
129Rap1 signaling pathway_Homo sapiens_hsa040150.50652700
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50089323
131Arachidonic acid metabolism_Homo sapiens_hsa005900.49869012
132Ether lipid metabolism_Homo sapiens_hsa005650.48938186
133B cell receptor signaling pathway_Homo sapiens_hsa046620.47320165
134Leishmaniasis_Homo sapiens_hsa051400.47300524
135Pancreatic cancer_Homo sapiens_hsa052120.47174874
136Viral myocarditis_Homo sapiens_hsa054160.47023232
137Gastric acid secretion_Homo sapiens_hsa049710.46932396
138Circadian rhythm_Homo sapiens_hsa047100.46336244
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45453758
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45154148
141Osteoclast differentiation_Homo sapiens_hsa043800.44296268
142FoxO signaling pathway_Homo sapiens_hsa040680.43408569
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43245862
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43188064
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41928601
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41343660
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39284074
148Toxoplasmosis_Homo sapiens_hsa051450.38878428
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38845362
150Melanoma_Homo sapiens_hsa052180.37835755
151Acute myeloid leukemia_Homo sapiens_hsa052210.37727452
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36592967
153TNF signaling pathway_Homo sapiens_hsa046680.35173284
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.34952986
155Endometrial cancer_Homo sapiens_hsa052130.33224463
156Other glycan degradation_Homo sapiens_hsa005110.32240567
157Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31906730
158Chemokine signaling pathway_Homo sapiens_hsa040620.31418330
159Inositol phosphate metabolism_Homo sapiens_hsa005620.31373194
160Hepatitis C_Homo sapiens_hsa051600.30266058
161Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29557181
162Oocyte meiosis_Homo sapiens_hsa041140.28496343

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