NCDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.72502609
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.58695114
3locomotory exploration behavior (GO:0035641)6.33202749
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.22554212
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.61840514
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.50830467
7vocalization behavior (GO:0071625)5.43859130
8regulation of glutamate receptor signaling pathway (GO:1900449)5.41047673
9synaptic vesicle exocytosis (GO:0016079)5.33407833
10* regulation of neuronal synaptic plasticity (GO:0048168)5.18193346
11glutamate secretion (GO:0014047)5.18088303
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.16608877
13regulation of synapse structural plasticity (GO:0051823)5.08198485
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.07999621
15cerebellar granule cell differentiation (GO:0021707)5.06569027
16exploration behavior (GO:0035640)5.03873977
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.96571481
18regulation of synaptic vesicle exocytosis (GO:2000300)4.95278753
19amino acid import (GO:0043090)4.72707425
20protein localization to synapse (GO:0035418)4.68037698
21regulation of synaptic vesicle transport (GO:1902803)4.52504704
22neuronal action potential propagation (GO:0019227)4.51528572
23neurotransmitter secretion (GO:0007269)4.43901992
24long-term memory (GO:0007616)4.42301405
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40762311
26dendritic spine morphogenesis (GO:0060997)4.33522620
27potassium ion homeostasis (GO:0055075)4.29974173
28synaptic transmission, glutamatergic (GO:0035249)4.28917859
29neurotransmitter-gated ion channel clustering (GO:0072578)4.22245875
30glutamate receptor signaling pathway (GO:0007215)4.19271670
31regulation of dendritic spine morphogenesis (GO:0061001)4.13663625
32positive regulation of membrane potential (GO:0045838)4.13054250
33cellular potassium ion homeostasis (GO:0030007)4.10748513
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09600652
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.09024956
36sodium ion export (GO:0071436)4.03632651
37potassium ion import (GO:0010107)4.03171435
38* regulation of synaptic plasticity (GO:0048167)4.01952396
39negative regulation of dendrite morphogenesis (GO:0050774)3.99338044
40layer formation in cerebral cortex (GO:0021819)3.96993743
41regulation of synapse maturation (GO:0090128)3.96679471
42central nervous system myelination (GO:0022010)3.95834252
43axon ensheathment in central nervous system (GO:0032291)3.95834252
44neuromuscular process controlling balance (GO:0050885)3.95765326
45neuron-neuron synaptic transmission (GO:0007270)3.95550867
46regulation of voltage-gated calcium channel activity (GO:1901385)3.95207675
47postsynaptic membrane organization (GO:0001941)3.88557537
48positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.83829491
49positive regulation of synapse maturation (GO:0090129)3.82454554
50gamma-aminobutyric acid transport (GO:0015812)3.80675231
51regulation of postsynaptic membrane potential (GO:0060078)3.79366916
52proline transport (GO:0015824)3.76248296
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.74581506
54neuron cell-cell adhesion (GO:0007158)3.69969445
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.68997227
56long-term synaptic potentiation (GO:0060291)3.66895896
57activation of protein kinase A activity (GO:0034199)3.65750339
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65615165
59neuromuscular process controlling posture (GO:0050884)3.62874377
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54223258
61dendritic spine organization (GO:0097061)3.52444848
62neurotransmitter transport (GO:0006836)3.50617321
63cell communication by electrical coupling (GO:0010644)3.48699742
64behavioral defense response (GO:0002209)3.46091177
65behavioral fear response (GO:0001662)3.46091177
66prepulse inhibition (GO:0060134)3.45075500
67neuronal ion channel clustering (GO:0045161)3.43985194
68auditory behavior (GO:0031223)3.43739142
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.43734120
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.41976994
71acidic amino acid transport (GO:0015800)3.41039608
72synaptic vesicle endocytosis (GO:0048488)3.39051536
73transmission of nerve impulse (GO:0019226)3.38855013
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38842494
75positive regulation of dendritic spine development (GO:0060999)3.37483218
76regulation of neurotransmitter levels (GO:0001505)3.34964534
77regulation of neurotransmitter secretion (GO:0046928)3.34757033
78vesicle docking involved in exocytosis (GO:0006904)3.34363603
79glycine transport (GO:0015816)3.33153194
80regulation of dendritic spine development (GO:0060998)3.32041685
81L-amino acid import (GO:0043092)3.31206162
82positive regulation of neurotransmitter transport (GO:0051590)3.30848206
83positive regulation of neurotransmitter secretion (GO:0001956)3.29829692
84regulation of vesicle fusion (GO:0031338)3.29758915
85regulation of ARF protein signal transduction (GO:0032012)3.27357593
86response to auditory stimulus (GO:0010996)3.26226599
87neurotransmitter uptake (GO:0001504)3.24332001
88vesicle transport along microtubule (GO:0047496)3.23480668
89establishment of synaptic vesicle localization (GO:0097480)3.22470244
90synaptic vesicle transport (GO:0048489)3.22470244
91membrane depolarization (GO:0051899)3.20900173
92chemosensory behavior (GO:0007635)3.20736191
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18637792
94learning (GO:0007612)3.16910075
95positive regulation of synaptic transmission (GO:0050806)3.16778435
96regulation of neurotransmitter transport (GO:0051588)3.15002368
97innervation (GO:0060384)3.13700419
98neuron recognition (GO:0008038)3.13642152
99* regulation of synaptic transmission (GO:0050804)3.12522067
100neuromuscular process (GO:0050905)3.12447728
101fear response (GO:0042596)3.11810942
102cellular sodium ion homeostasis (GO:0006883)3.11464040
103neuromuscular synaptic transmission (GO:0007274)3.09903357
104regulation of female receptivity (GO:0045924)3.08875738
105dicarboxylic acid transport (GO:0006835)3.08062838
106cell differentiation in hindbrain (GO:0021533)3.07874991
107cell communication involved in cardiac conduction (GO:0086065)3.07874806
108vesicle docking (GO:0048278)3.07584265
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06395753
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05707709
111signal complex assembly (GO:0007172)3.05535377
112membrane depolarization during action potential (GO:0086010)3.05430190
113dendrite morphogenesis (GO:0048813)3.04732067
114cerebellar Purkinje cell differentiation (GO:0021702)3.03241888
115positive regulation of dendrite development (GO:1900006)3.03093350
116regulation of exocytosis (GO:0017157)3.02256668
117membrane hyperpolarization (GO:0060081)3.00825752
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96965227
119response to histamine (GO:0034776)2.96920261
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.96547831
121synaptic transmission (GO:0007268)2.96443952
122cerebellar Purkinje cell layer development (GO:0021680)2.95907841
123visual learning (GO:0008542)2.93924350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02402681
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.30609542
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19780989
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16854796
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14887010
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90569299
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90569299
8REST_21632747_ChIP-Seq_MESCs_Mouse2.88093209
9GBX2_23144817_ChIP-Seq_PC3_Human2.85860710
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84327284
11DROSHA_22980978_ChIP-Seq_HELA_Human2.78397367
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70760854
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68079629
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.67909278
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64611675
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55895498
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.52875108
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49610022
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.49342144
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.47040396
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.44677385
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.40147859
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40116761
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.30394171
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.20551664
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13134083
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.84793044
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81328687
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79891011
30AR_21572438_ChIP-Seq_LNCaP_Human1.69908756
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62540453
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50701074
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49469038
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47501070
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.46240150
36KDM2B_26808549_Chip-Seq_K562_Human1.41424574
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41072819
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38211660
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.38062612
40SMAD4_21799915_ChIP-Seq_A2780_Human1.36697524
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32718277
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31599084
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29806310
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28198535
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27720274
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26465034
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26453833
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25947356
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25879778
50* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24452426
51ZNF274_21170338_ChIP-Seq_K562_Hela1.20902858
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.19465471
53AR_19668381_ChIP-Seq_PC3_Human1.19085789
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.19041150
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18551598
56* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17265432
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15762891
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12578687
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09240030
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08994550
61KDM2B_26808549_Chip-Seq_DND41_Human1.08810783
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08452869
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08375375
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08280951
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.07817887
66OCT4_19829295_ChIP-Seq_ESCs_Human1.06956050
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06406683
68AR_25329375_ChIP-Seq_VCAP_Human1.06217954
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04636627
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04539352
71* CTCF_27219007_Chip-Seq_Bcells_Human1.04142986
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03687252
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.03687146
74* CREB1_26743006_Chip-Seq_LNCaP_Human1.03201952
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01945280
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00887226
77STAT3_23295773_ChIP-Seq_U87_Human0.99925865
78* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98005037
79P68_20966046_ChIP-Seq_HELA_Human0.97819174
80DPY_21335234_ChIP-Seq_ESCs_Mouse0.97007430
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96563419
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96458592
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95901641
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95029419
85SMAD3_21741376_ChIP-Seq_HESCs_Human0.94895747
86P300_19829295_ChIP-Seq_ESCs_Human0.93886919
87* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93565858
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92664504
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92030998
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.91967040
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.90580560
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90520975
93TAF15_26573619_Chip-Seq_HEK293_Human0.89890679
94RXR_22108803_ChIP-Seq_LS180_Human0.89598008
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89245684
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.88939215
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88296567
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87867391
99KLF4_19829295_ChIP-Seq_ESCs_Human0.87502815
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.87332538
101TET1_21451524_ChIP-Seq_MESCs_Mouse0.87320576
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86939141
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86314688
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85756719
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.84364360
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.84355137
107TCF4_23295773_ChIP-Seq_U87_Human0.84349851
108MYC_19915707_ChIP-ChIP_AK7_Human0.84002179
109TP53_23651856_ChIP-Seq_MEFs_Mouse0.83684637
110* LXR_22292898_ChIP-Seq_THP-1_Human0.83472223
111SMC4_20622854_ChIP-Seq_HELA_Human0.83339009
112RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83325633
113AHR_22903824_ChIP-Seq_MCF-7_Human0.83144247
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83102530
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83018225
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.82471943
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82107199
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82081190
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81847425
120SMAD4_21741376_ChIP-Seq_ESCs_Human0.81096749
121RNF2_27304074_Chip-Seq_NSC_Mouse0.80679493
122EGR1_19032775_ChIP-ChIP_M12_Human0.80528451
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80390100
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78878637
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78296237
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77701688
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77426269
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.76878062
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.76668203
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.75821899
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74477394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.10451181
2MP0003880_abnormal_central_pattern4.92741763
3* MP0003635_abnormal_synaptic_transmissio4.44886438
4MP0002822_catalepsy4.07126394
5MP0004270_analgesia3.72272248
6* MP0002063_abnormal_learning/memory/cond3.57258175
7* MP0009745_abnormal_behavioral_response3.56790662
8* MP0002064_seizures3.25619100
9MP0009046_muscle_twitch2.88741635
10MP0002572_abnormal_emotion/affect_behav2.85575929
11MP0001968_abnormal_touch/_nociception2.77087308
12MP0005423_abnormal_somatic_nervous2.69958763
13MP0002272_abnormal_nervous_system2.61629435
14MP0001486_abnormal_startle_reflex2.56323546
15MP0002734_abnormal_mechanical_nocicepti2.38603725
16MP0001501_abnormal_sleep_pattern2.32094860
17MP0002735_abnormal_chemical_nociception2.11606996
18MP0003329_amyloid_beta_deposits2.11263536
19MP0002736_abnormal_nociception_after2.06254124
20MP0004858_abnormal_nervous_system2.01631670
21MP0008569_lethality_at_weaning1.96690097
22MP0009780_abnormal_chondrocyte_physiolo1.94967248
23MP0001440_abnormal_grooming_behavior1.94635901
24MP0004811_abnormal_neuron_physiology1.91771058
25MP0002909_abnormal_adrenal_gland1.89587946
26MP0001970_abnormal_pain_threshold1.87101245
27MP0002733_abnormal_thermal_nociception1.86047785
28MP0005646_abnormal_pituitary_gland1.70260543
29MP0002067_abnormal_sensory_capabilities1.69681925
30MP0002557_abnormal_social/conspecific_i1.64513616
31MP0004924_abnormal_behavior1.61504462
32MP0005386_behavior/neurological_phenoty1.61504462
33MP0003075_altered_response_to1.60123366
34MP0002184_abnormal_innervation1.57664198
35MP0003879_abnormal_hair_cell1.51913180
36MP0000955_abnormal_spinal_cord1.51479699
37MP0004885_abnormal_endolymph1.50406502
38MP0000778_abnormal_nervous_system1.48632308
39MP0003787_abnormal_imprinting1.48351909
40MP0003633_abnormal_nervous_system1.46529255
41* MP0002066_abnormal_motor_capabilities/c1.38980483
42MP0002882_abnormal_neuron_morphology1.35358024
43MP0001984_abnormal_olfaction1.29836262
44MP0001905_abnormal_dopamine_level1.23671866
45MP0001529_abnormal_vocalization1.22570136
46MP0003631_nervous_system_phenotype1.21555798
47MP0010234_abnormal_vibrissa_follicle1.18513557
48MP0001348_abnormal_lacrimal_gland1.17515962
49MP0006276_abnormal_autonomic_nervous1.16871957
50MP0001502_abnormal_circadian_rhythm1.08670423
51MP0008874_decreased_physiological_sensi1.07880401
52MP0003690_abnormal_glial_cell1.06062956
53MP0008872_abnormal_physiological_respon1.05273529
54MP0004142_abnormal_muscle_tone1.05174958
55MP0000604_amyloidosis1.03693351
56MP0001177_atelectasis1.02058938
57* MP0002152_abnormal_brain_morphology1.01098524
58MP0008961_abnormal_basal_metabolism1.00443911
59MP0000751_myopathy0.99383899
60MP0005645_abnormal_hypothalamus_physiol0.99137043
61MP0003283_abnormal_digestive_organ0.98932203
62MP0005167_abnormal_blood-brain_barrier0.97797650
63MP0002069_abnormal_eating/drinking_beha0.96530708
64MP0003122_maternal_imprinting0.93892766
65MP0005535_abnormal_body_temperature0.89216670
66MP0000920_abnormal_myelination0.88834383
67MP0000013_abnormal_adipose_tissue0.88247522
68MP0002229_neurodegeneration0.87444811
69MP0000569_abnormal_digit_pigmentation0.84796070
70MP0004085_abnormal_heartbeat0.83732290
71MP0004147_increased_porphyrin_level0.82640420
72MP0003632_abnormal_nervous_system0.82422376
73MP0004510_myositis0.78342712
74MP0002090_abnormal_vision0.76378085
75* MP0003634_abnormal_glial_cell0.75684428
76MP0003172_abnormal_lysosome_physiology0.73154338
77MP0000579_abnormal_nail_morphology0.68921480
78MP0005499_abnormal_olfactory_system0.68134656
79MP0005394_taste/olfaction_phenotype0.68134656
80MP0005409_darkened_coat_color0.67364347
81MP0010386_abnormal_urinary_bladder0.66638871
82MP0001963_abnormal_hearing_physiology0.64269370
83MP0005166_decreased_susceptibility_to0.64167797
84MP0004145_abnormal_muscle_electrophysio0.63859695
85MP0001188_hyperpigmentation0.63812772
86MP0001986_abnormal_taste_sensitivity0.62632546
87MP0005623_abnormal_meninges_morphology0.62248161
88MP0003137_abnormal_impulse_conducting0.62152336
89MP0005551_abnormal_eye_electrophysiolog0.60698763
90MP0002638_abnormal_pupillary_reflex0.59461212
91MP0004484_altered_response_of0.58792153
92MP0001664_abnormal_digestion0.57906903
93MP0004233_abnormal_muscle_weight0.57316587
94MP0002752_abnormal_somatic_nervous0.56458802
95MP0010768_mortality/aging0.55855242
96MP0004215_abnormal_myocardial_fiber0.55350593
97MP0002082_postnatal_lethality0.53443260
98MP0010770_preweaning_lethality0.53443260
99MP0004742_abnormal_vestibular_system0.51866276
100MP0002249_abnormal_larynx_morphology0.51703038
101MP0003123_paternal_imprinting0.51531400
102MP0003861_abnormal_nervous_system0.50766551
103MP0001485_abnormal_pinna_reflex0.50516268
104MP0000631_abnormal_neuroendocrine_gland0.49893644
105MP0002089_abnormal_postnatal_growth/wei0.49457477
106MP0004043_abnormal_pH_regulation0.49121952
107MP0010769_abnormal_survival0.48785674
108MP0003956_abnormal_body_size0.48625471
109MP0001299_abnormal_eye_distance/0.48535529
110MP0004130_abnormal_muscle_cell0.47486023
111MP0001943_abnormal_respiration0.47465335
112MP0008877_abnormal_DNA_methylation0.47251269
113MP0002873_normal_phenotype0.46344849
114MP0001765_abnormal_ion_homeostasis0.45414884
115MP0002169_no_abnormal_phenotype0.44712633
116MP0001731_abnormal_postnatal_growth0.44263309
117MP0000747_muscle_weakness0.42146605

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.68143798
2Focal motor seizures (HP:0011153)7.84253335
3Focal seizures (HP:0007359)5.92009957
4Visual hallucinations (HP:0002367)5.59916701
5Action tremor (HP:0002345)4.48118028
6Epileptic encephalopathy (HP:0200134)4.37485971
7Progressive cerebellar ataxia (HP:0002073)4.07663123
8Atonic seizures (HP:0010819)4.05608354
9Febrile seizures (HP:0002373)3.96263730
10Absence seizures (HP:0002121)3.89218026
11Supranuclear gaze palsy (HP:0000605)3.88154894
12Impaired vibration sensation in the lower limbs (HP:0002166)3.83945144
13Generalized tonic-clonic seizures (HP:0002069)3.82730452
14Ankle clonus (HP:0011448)3.79304908
15Depression (HP:0000716)3.77475692
16Abnormality of the lower motor neuron (HP:0002366)3.74393608
17Dialeptic seizures (HP:0011146)3.62637121
18Cerebral hypomyelination (HP:0006808)3.58936366
19Poor eye contact (HP:0000817)3.48198653
20Anxiety (HP:0000739)3.46205442
21Annular pancreas (HP:0001734)3.46047843
22Postural instability (HP:0002172)3.42478315
23Dysmetria (HP:0001310)3.34987384
24Torticollis (HP:0000473)3.34932669
25Dysdiadochokinesis (HP:0002075)3.23179448
26Mutism (HP:0002300)3.22276513
27Abnormal social behavior (HP:0012433)3.18893835
28Impaired social interactions (HP:0000735)3.18893835
29Urinary bladder sphincter dysfunction (HP:0002839)3.18225749
30Focal dystonia (HP:0004373)3.18132107
31Broad-based gait (HP:0002136)3.16843797
32Gaze-evoked nystagmus (HP:0000640)3.16652241
33Papilledema (HP:0001085)3.13729591
34Abnormal eating behavior (HP:0100738)3.07649239
35Ventricular fibrillation (HP:0001663)3.00708547
36Urinary urgency (HP:0000012)2.92567130
37Akinesia (HP:0002304)2.92298616
38Truncal ataxia (HP:0002078)2.89343652
39Intention tremor (HP:0002080)2.85631271
40Amblyopia (HP:0000646)2.82489015
41Craniofacial dystonia (HP:0012179)2.79865931
42Hemiplegia (HP:0002301)2.78080676
43Stereotypic behavior (HP:0000733)2.77666580
44Bradykinesia (HP:0002067)2.75758486
45Pointed chin (HP:0000307)2.70160866
46Spastic gait (HP:0002064)2.68494489
47Cerebral inclusion bodies (HP:0100314)2.67854337
48Peripheral hypomyelination (HP:0007182)2.66791565
49Impaired smooth pursuit (HP:0007772)2.66416205
50Neurofibrillary tangles (HP:0002185)2.63498394
51Megalencephaly (HP:0001355)2.62582426
52Sleep apnea (HP:0010535)2.54543868
53Impaired vibratory sensation (HP:0002495)2.54308021
54Bundle branch block (HP:0011710)2.50475259
55Genetic anticipation (HP:0003743)2.48416734
56Insomnia (HP:0100785)2.46399103
57Scanning speech (HP:0002168)2.44916714
58Hemiparesis (HP:0001269)2.36296550
59Dysmetric saccades (HP:0000641)2.34549571
60Abnormality of ocular smooth pursuit (HP:0000617)2.33459460
61Progressive inability to walk (HP:0002505)2.32658264
62Hyperventilation (HP:0002883)2.31451627
63Resting tremor (HP:0002322)2.30721909
64Ankyloglossia (HP:0010296)2.27994592
65Diplopia (HP:0000651)2.27928767
66Abnormality of binocular vision (HP:0011514)2.27928767
67Spastic tetraparesis (HP:0001285)2.26943974
68Excessive salivation (HP:0003781)2.24768134
69Drooling (HP:0002307)2.24768134
70Choreoathetosis (HP:0001266)2.23980179
71Lower limb muscle weakness (HP:0007340)2.22647875
72CNS hypomyelination (HP:0003429)2.21264067
73Epileptiform EEG discharges (HP:0011182)2.20628542
74Obstructive sleep apnea (HP:0002870)2.18755017
75Incomplete penetrance (HP:0003829)2.18276173
76Lower limb asymmetry (HP:0100559)2.16489997
77Distal upper limb amyotrophy (HP:0007149)2.16037553
78Upper limb amyotrophy (HP:0009129)2.16037553
79Termporal pattern (HP:0011008)2.15132500
80Insidious onset (HP:0003587)2.15132500
81Delusions (HP:0000746)2.15020618
82Hand muscle atrophy (HP:0009130)2.14191580
83EEG with generalized epileptiform discharges (HP:0011198)2.12567511
84Status epilepticus (HP:0002133)2.12280411
85Rapidly progressive (HP:0003678)2.11989937
86Abnormal EKG (HP:0003115)2.09240403
87Hypsarrhythmia (HP:0002521)2.07062620
88Generalized myoclonic seizures (HP:0002123)2.07046003
89Clonus (HP:0002169)2.06909445
90Apathy (HP:0000741)2.06799856
91Fetal akinesia sequence (HP:0001989)2.04595645
92Lower limb amyotrophy (HP:0007210)2.00492887
93Rigidity (HP:0002063)1.99262997
94Aplasia involving bones of the upper limbs (HP:0009823)1.98633463
95Aplasia of the phalanges of the hand (HP:0009802)1.98633463
96Aplasia involving bones of the extremities (HP:0009825)1.98633463
97Gait ataxia (HP:0002066)1.92584229
98Abnormality of saccadic eye movements (HP:0000570)1.92292130
99Spinal canal stenosis (HP:0003416)1.89844285
100Neuronal loss in central nervous system (HP:0002529)1.89834264
101Abnormality of the periventricular white matter (HP:0002518)1.89631372
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88953766
103Degeneration of the lateral corticospinal tracts (HP:0002314)1.88953766
104Morphological abnormality of the pyramidal tract (HP:0002062)1.87960474
105Abnormality of the corticospinal tract (HP:0002492)1.84923386
106Bronchomalacia (HP:0002780)1.82847170
107Tetraplegia (HP:0002445)1.82461351
108Diminished motivation (HP:0000745)1.80272370
109Anosmia (HP:0000458)1.78449479
110Slow saccadic eye movements (HP:0000514)1.78047854
111Heart block (HP:0012722)1.77470305
112Absent speech (HP:0001344)1.76636860
113Limb dystonia (HP:0002451)1.76352975
114Slow progression (HP:0003677)1.75818432
115Deep palmar crease (HP:0006191)1.75427066
116Pheochromocytoma (HP:0002666)1.75017360
117Polyphagia (HP:0002591)1.74135142
118Amyotrophic lateral sclerosis (HP:0007354)1.73947800
119Distal sensory impairment (HP:0002936)1.73037083
120Dementia (HP:0000726)1.72142089
121Psychosis (HP:0000709)1.72072440
122Increased circulating renin level (HP:0000848)1.70250312
123Agitation (HP:0000713)1.69573386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.40501260
2NTRK34.82166628
3MAP3K94.37389248
4KSR23.02260374
5PRKD32.84582984
6MINK12.70995146
7DAPK22.48821537
8PAK62.39220586
9ARAF2.27745262
10MAP3K42.27281949
11MAP3K132.20674404
12CAMKK12.03636567
13MARK12.03065248
14KSR11.89688986
15RIPK41.88349386
16NTRK11.84321761
17NTRK21.81434668
18MAP2K71.68966689
19FES1.63491078
20CDK51.61424030
21PRPF4B1.59375460
22STK381.55097067
23DAPK11.49130409
24MAP3K121.45578357
25MAP2K41.45545336
26MAP3K21.44690144
27RAF11.28952951
28TYRO31.25671498
29GRK51.25579849
30TNIK1.25233838
31PTK2B1.19894075
32TAOK11.19078516
33PRKCG1.15351001
34CAMK11.14695449
35SIK21.11953573
36PLK21.06784299
37UHMK11.05318008
38LMTK21.02574883
39PRKCH1.01764272
40PINK10.95631802
41CDK190.95431469
42ALK0.94232715
43CDK180.93520919
44CDK150.92834156
45MAP3K10.90393942
46MAPK120.89028557
47CAMK2A0.87838701
48CDK140.87270551
49LATS20.87247044
50PDK10.86731249
51MAPK130.85358021
52CAMK2B0.82971644
53SGK2230.82507983
54SGK4940.82507983
55CDK11A0.81188099
56MAP3K110.80721153
57STK110.79901664
58NEK10.79082691
59LIMK10.79000449
60PDPK10.78724738
61TESK10.76348495
62RET0.75902427
63PAK30.72417486
64PHKG20.71919539
65PHKG10.71919539
66MAP3K70.68725596
67TNK20.66282779
68SGK30.66167621
69MARK20.65753349
70CAMKK20.64294767
71SGK10.62500003
72SGK20.59697508
73PKN10.59217624
74PNCK0.57832419
75MAP2K10.57201175
76DYRK1A0.56461537
77FER0.56285398
78MOS0.55545939
79BRSK10.54861164
80BMPR20.54707955
81CAMK40.54135501
82NME10.52495896
83NEK60.52178564
84WNK10.51787893
85ROCK20.51261535
86RPS6KA30.49882356
87BRAF0.48944375
88RIPK10.48649006
89ICK0.47438469
90PRKCZ0.46889736
91FYN0.46301451
92MAPK100.44118935
93DMPK0.43945948
94DDR20.42665136
95DAPK30.42466556
96CDC42BPA0.42389420
97FGFR20.42276862
98TRIB30.42189064
99CAMK2G0.42007878
100PRKG20.41930901
101FGR0.41434592
102OXSR10.39085254
103CAMK2D0.38839472
104SCYL20.37419395
105PRKD20.35293466
106IRAK20.35090083
107CSNK1G20.32290246
108PRKCE0.31702460
109ROCK10.31196087
110CAMK1G0.29835148
111MAPK80.28846895
112PRKCB0.28375349
113CCNB10.28341674
114PRKCA0.27755597
115CASK0.27605823
116RPS6KA20.26925574
117SRC0.25491696
118TAOK20.24831002
119MAP2K60.24239468

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.27527518
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18637049
3Olfactory transduction_Homo sapiens_hsa047403.16821176
4Long-term potentiation_Homo sapiens_hsa047202.85570571
5Circadian entrainment_Homo sapiens_hsa047132.76587967
6Amphetamine addiction_Homo sapiens_hsa050312.60190671
7GABAergic synapse_Homo sapiens_hsa047272.59128354
8Glutamatergic synapse_Homo sapiens_hsa047242.51996742
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45592736
10Morphine addiction_Homo sapiens_hsa050322.37837286
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33450421
12Salivary secretion_Homo sapiens_hsa049702.20624431
13Dopaminergic synapse_Homo sapiens_hsa047282.13159205
14Gastric acid secretion_Homo sapiens_hsa049712.05810629
15Insulin secretion_Homo sapiens_hsa049112.02441412
16Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01824338
17Cholinergic synapse_Homo sapiens_hsa047252.00052056
18Vitamin B6 metabolism_Homo sapiens_hsa007501.75374095
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75325705
20Oxytocin signaling pathway_Homo sapiens_hsa049211.75258073
21Nitrogen metabolism_Homo sapiens_hsa009101.72995197
22Cocaine addiction_Homo sapiens_hsa050301.66685795
23Calcium signaling pathway_Homo sapiens_hsa040201.64632085
24GnRH signaling pathway_Homo sapiens_hsa049121.63513324
25Renin secretion_Homo sapiens_hsa049241.60042233
26Long-term depression_Homo sapiens_hsa047301.57725059
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57062105
28Taste transduction_Homo sapiens_hsa047421.45067368
29Serotonergic synapse_Homo sapiens_hsa047261.43369989
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41627604
31Glioma_Homo sapiens_hsa052141.37396901
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37243352
33Gap junction_Homo sapiens_hsa045401.34646851
34cAMP signaling pathway_Homo sapiens_hsa040241.32926080
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24681087
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18339497
37Estrogen signaling pathway_Homo sapiens_hsa049151.18065023
38Type II diabetes mellitus_Homo sapiens_hsa049301.15587895
39Collecting duct acid secretion_Homo sapiens_hsa049661.11102207
40Melanogenesis_Homo sapiens_hsa049161.08751404
41ErbB signaling pathway_Homo sapiens_hsa040121.07775145
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05373207
43Oocyte meiosis_Homo sapiens_hsa041140.98164579
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.96164214
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.95952062
46Axon guidance_Homo sapiens_hsa043600.93400414
47Dorso-ventral axis formation_Homo sapiens_hsa043200.92423580
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91051733
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87603995
50Pancreatic secretion_Homo sapiens_hsa049720.83205661
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81425406
52Thyroid hormone synthesis_Homo sapiens_hsa049180.81120695
53VEGF signaling pathway_Homo sapiens_hsa043700.79528804
54Cardiac muscle contraction_Homo sapiens_hsa042600.79461593
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78824324
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78590369
57Choline metabolism in cancer_Homo sapiens_hsa052310.78009495
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.76439810
59Vibrio cholerae infection_Homo sapiens_hsa051100.71380445
60Dilated cardiomyopathy_Homo sapiens_hsa054140.69661122
61MAPK signaling pathway_Homo sapiens_hsa040100.67665165
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66794744
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66240273
64Glucagon signaling pathway_Homo sapiens_hsa049220.63702659
65Rap1 signaling pathway_Homo sapiens_hsa040150.62951698
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61449279
67Non-small cell lung cancer_Homo sapiens_hsa052230.61428470
68Endocytosis_Homo sapiens_hsa041440.59608010
69Bile secretion_Homo sapiens_hsa049760.58835657
70mTOR signaling pathway_Homo sapiens_hsa041500.57829189
71Prion diseases_Homo sapiens_hsa050200.56574733
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.55775883
73Ras signaling pathway_Homo sapiens_hsa040140.55016444
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53659733
75Phototransduction_Homo sapiens_hsa047440.53373849
76Type I diabetes mellitus_Homo sapiens_hsa049400.52177646
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52059830
78Alcoholism_Homo sapiens_hsa050340.50136051
79Arginine and proline metabolism_Homo sapiens_hsa003300.48481343
80Inositol phosphate metabolism_Homo sapiens_hsa005620.46589058
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45648788
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45286315
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44878788
84Endometrial cancer_Homo sapiens_hsa052130.43785940
85Chemokine signaling pathway_Homo sapiens_hsa040620.41021404
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40859337
87African trypanosomiasis_Homo sapiens_hsa051430.40097531
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40062198
89Insulin signaling pathway_Homo sapiens_hsa049100.38095833
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37454296
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37002757
92Renal cell carcinoma_Homo sapiens_hsa052110.35990340
93Wnt signaling pathway_Homo sapiens_hsa043100.35225814
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34518773
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34065898
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34000643
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33573988
98AMPK signaling pathway_Homo sapiens_hsa041520.31369575
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31141357
100Arginine biosynthesis_Homo sapiens_hsa002200.30983735
101HIF-1 signaling pathway_Homo sapiens_hsa040660.30323607
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30321412
103Fatty acid biosynthesis_Homo sapiens_hsa000610.30241722
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27534631
105Tight junction_Homo sapiens_hsa045300.26401838
106Circadian rhythm_Homo sapiens_hsa047100.26320236
107Ovarian steroidogenesis_Homo sapiens_hsa049130.26261513
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.25272656
109Platelet activation_Homo sapiens_hsa046110.25169881
110Mineral absorption_Homo sapiens_hsa049780.23308102
111Hippo signaling pathway_Homo sapiens_hsa043900.20158919

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