NCEH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.85027141
2protein localization to endosome (GO:0036010)5.60754042
3cell adhesion mediated by integrin (GO:0033627)5.51089160
4glycosphingolipid catabolic process (GO:0046479)5.39349716
5oligosaccharide catabolic process (GO:0009313)5.35256695
6glycolipid catabolic process (GO:0019377)4.88080201
7membrane raft organization (GO:0031579)4.71097840
8barbed-end actin filament capping (GO:0051016)4.46844753
9apoptotic cell clearance (GO:0043277)4.37106075
10iron ion import (GO:0097286)4.34544171
11skin morphogenesis (GO:0043589)4.20546172
12ceramide catabolic process (GO:0046514)4.19249529
13COPI coating of Golgi vesicle (GO:0048205)4.10496704
14Golgi transport vesicle coating (GO:0048200)4.10496704
15regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.71448311
16cellular copper ion homeostasis (GO:0006878)3.55028367
17membrane lipid catabolic process (GO:0046466)3.51451520
18substrate-dependent cell migration (GO:0006929)3.45905763
19amino sugar catabolic process (GO:0046348)3.44383921
20dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.42592172
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.40928600
22ATP hydrolysis coupled proton transport (GO:0015991)3.40928600
23hypotonic response (GO:0006971)3.39176418
24synaptic vesicle exocytosis (GO:0016079)3.36838784
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.33951268
26sphingolipid catabolic process (GO:0030149)3.33320242
27regulation of mononuclear cell migration (GO:0071675)3.30192501
28regulation of early endosome to late endosome transport (GO:2000641)3.29299660
29positive regulation of extracellular matrix organization (GO:1903055)3.27833234
30regulation of cholesterol storage (GO:0010885)3.26071996
31cellular potassium ion homeostasis (GO:0030007)3.23130064
32eosinophil chemotaxis (GO:0048245)3.20691497
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19297158
34hemidesmosome assembly (GO:0031581)3.17857465
35decidualization (GO:0046697)3.17250525
36osteoclast differentiation (GO:0030316)3.16973254
37cortical actin cytoskeleton organization (GO:0030866)3.15319178
38pinocytosis (GO:0006907)3.13602626
39phagosome maturation (GO:0090382)3.12501081
40transferrin transport (GO:0033572)3.11882705
41hyaluronan catabolic process (GO:0030214)3.11643170
42positive regulation of leukocyte degranulation (GO:0043302)3.11340236
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06422648
44regulation of metalloenzyme activity (GO:0048552)3.05735224
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00527751
46neuronal action potential propagation (GO:0019227)2.99994180
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97477263
48negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.95243230
49regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95097191
50trivalent inorganic cation transport (GO:0072512)2.93099632
51ferric iron transport (GO:0015682)2.93099632
52ionotropic glutamate receptor signaling pathway (GO:0035235)2.91965923
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91822682
54vocalization behavior (GO:0071625)2.91764688
55positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91313716
56negative regulation of protein localization to plasma membrane (GO:1903077)2.90984875
57glutamate secretion (GO:0014047)2.90920516
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90917277
59cellular response to arsenic-containing substance (GO:0071243)2.89748277
60keratan sulfate catabolic process (GO:0042340)2.87917736
61regulation of macrophage chemotaxis (GO:0010758)2.87675789
62endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.86461586
63regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85764784
64negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.85309776
65regulation of synaptic vesicle exocytosis (GO:2000300)2.84909578
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.84588898
67regulation of glutamate receptor signaling pathway (GO:1900449)2.84460175
68eosinophil migration (GO:0072677)2.84337685
69positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81624478
70regulation of transforming growth factor beta1 production (GO:0032908)2.78222260
71gamma-aminobutyric acid signaling pathway (GO:0007214)2.78132401
72regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77703812
73protein retention in ER lumen (GO:0006621)2.77633074
74cortical cytoskeleton organization (GO:0030865)2.77468345
75regulation of cell communication by electrical coupling (GO:0010649)2.77162921
76positive regulation of monocyte chemotaxis (GO:0090026)2.76522110
77retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76123241
78positive regulation of bone remodeling (GO:0046852)2.76010353
79positive regulation of bone resorption (GO:0045780)2.76010353
80synaptic vesicle maturation (GO:0016188)2.75431822
81stress fiber assembly (GO:0043149)2.74812695
82membrane protein ectodomain proteolysis (GO:0006509)2.73981819
83regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.73838317
84locomotory exploration behavior (GO:0035641)2.73816576
85relaxation of cardiac muscle (GO:0055119)2.72566349
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72383074
87positive regulation by organism of defense response of other organism involved in symbiotic interact2.72383074
88modulation by symbiont of host immune response (GO:0052553)2.72383074
89positive regulation by symbiont of host defense response (GO:0052509)2.72383074
90modulation by symbiont of host defense response (GO:0052031)2.72383074
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72383074
92sphingosine metabolic process (GO:0006670)2.72211353
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71667488
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71415959
95regulation of synaptic vesicle transport (GO:1902803)2.70006053
96sodium ion export (GO:0071436)2.69998227
97glutamate receptor signaling pathway (GO:0007215)2.68928642
98regulation of integrin-mediated signaling pathway (GO:2001044)2.68715430
99epithelial cell-cell adhesion (GO:0090136)2.66732710
100detection of calcium ion (GO:0005513)2.66643899
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.65381203
102glucosamine-containing compound catabolic process (GO:1901072)2.64584114
103negative regulation of nitric oxide biosynthetic process (GO:0045019)2.63851190
104positive regulation of receptor recycling (GO:0001921)2.61784541
105cellular response to vitamin D (GO:0071305)2.58783689
106regulation of superoxide anion generation (GO:0032928)2.58521629
107regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58017853
108positive regulation of macrophage cytokine production (GO:0060907)2.55749653
109wound healing, spreading of epidermal cells (GO:0035313)2.54628939
110regulation of synapse structural plasticity (GO:0051823)2.54609265
111actin filament depolymerization (GO:0030042)2.54414181
112regulation of voltage-gated calcium channel activity (GO:1901385)2.54015460
113activation of Rac GTPase activity (GO:0032863)2.53902197
114cellular ketone body metabolic process (GO:0046950)2.53323900
115mesodermal cell differentiation (GO:0048333)2.53094811
116lysine metabolic process (GO:0006553)2.53056860
117lysine catabolic process (GO:0006554)2.53056860
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53029251
119tricarboxylic acid cycle (GO:0006099)2.52889105
120positive regulation of actin filament depolymerization (GO:0030836)2.52783357
121potassium ion import (GO:0010107)2.52402204
122regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51582837
123low-density lipoprotein particle clearance (GO:0034383)2.51209153
124positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.50962332
125negative regulation of response to reactive oxygen species (GO:1901032)2.50869550
126cell-substrate junction assembly (GO:0007044)2.50603581
127neuron-neuron synaptic transmission (GO:0007270)2.50404120
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50059087
129regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49743525
130copper ion homeostasis (GO:0055070)2.49163153
131aspartate family amino acid catabolic process (GO:0009068)2.48028992
132regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.48017567
133response to histamine (GO:0034776)2.47743356
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46331605
135mammary gland epithelial cell proliferation (GO:0033598)2.45378476
136protein maturation by protein folding (GO:0022417)2.45192324
137response to peptidoglycan (GO:0032494)2.45024411
138NADH metabolic process (GO:0006734)2.44772227
139vesicle coating (GO:0006901)2.44593901
140positive regulation of endothelial cell apoptotic process (GO:2000353)2.43681602
141cell communication by electrical coupling (GO:0010644)2.42944320
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.42745736
143neurotransmitter secretion (GO:0007269)2.42314578
144L-amino acid import (GO:0043092)2.41639888
145succinate metabolic process (GO:0006105)2.41355324
146lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41142729
147nucleobase-containing small molecule interconversion (GO:0015949)2.39318512
148positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.38387419
149neuron cell-cell adhesion (GO:0007158)2.38253131
150peptide catabolic process (GO:0043171)2.37758399
151proline transport (GO:0015824)2.37703821
152positive regulation of tissue remodeling (GO:0034105)2.37197679
153response to progesterone (GO:0032570)2.36837850
154synaptic transmission, glutamatergic (GO:0035249)2.36569362
155positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.36452232
156protein hydroxylation (GO:0018126)2.35866956
157regulation of protein localization to plasma membrane (GO:1903076)2.35551301
158neuromuscular process controlling posture (GO:0050884)2.35508512
159ketone body metabolic process (GO:1902224)2.35347146
160cellular response to thyroid hormone stimulus (GO:0097067)2.33920766
161regulation of excitatory postsynaptic membrane potential (GO:0060079)2.31668161
162regulation of calcium ion transmembrane transporter activity (GO:1901019)2.30552368
163regulation of calcium ion transmembrane transport (GO:1903169)2.30552368
164mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.30185315
165positive regulation of potassium ion transmembrane transport (GO:1901381)2.29487971
166protein localization to synapse (GO:0035418)2.27553179
167positive regulation of protein localization to plasma membrane (GO:1903078)2.26901698
168ganglioside metabolic process (GO:0001573)2.26828931
169activation of protein kinase A activity (GO:0034199)2.26338141
170neurotransmitter transport (GO:0006836)2.26122373
171gamma-aminobutyric acid transport (GO:0015812)2.25427105
172regulation of long-term neuronal synaptic plasticity (GO:0048169)2.21842287
173long-term synaptic potentiation (GO:0060291)2.21137524
174regulation of interferon-beta biosynthetic process (GO:0045357)2.21090666
175regulation of relaxation of muscle (GO:1901077)2.19599296
176neurotransmitter-gated ion channel clustering (GO:0072578)2.19234681
177regulation of neuronal synaptic plasticity (GO:0048168)2.19230157
178positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.19219077
179positive regulation of membrane potential (GO:0045838)2.18824982
180regulation of postsynaptic membrane potential (GO:0060078)2.18395647
181regulation of cardiac muscle cell contraction (GO:0086004)2.17860432
182regulation of acyl-CoA biosynthetic process (GO:0050812)2.17354501
183short-chain fatty acid metabolic process (GO:0046459)2.17327763
184oxaloacetate metabolic process (GO:0006107)2.15624527
1852-oxoglutarate metabolic process (GO:0006103)2.14626015
186long-term memory (GO:0007616)2.14587006
187drug transmembrane transport (GO:0006855)2.13630113
188regulation of actin filament-based movement (GO:1903115)2.13191152
189macrophage activation involved in immune response (GO:0002281)2.12929627
190glycosylceramide metabolic process (GO:0006677)2.12037076
191membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.11795276
192sarcoplasmic reticulum calcium ion transport (GO:0070296)2.11726073
193response to thyroid hormone (GO:0097066)2.11418240
194adult walking behavior (GO:0007628)2.10742056
195exploration behavior (GO:0035640)2.10490691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.04471134
2GBX2_23144817_ChIP-Seq_PC3_Human3.56092846
3EZH2_22144423_ChIP-Seq_EOC_Human3.50500005
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.42499831
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.40092535
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.32771496
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.10389851
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87734534
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66048275
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.61168555
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.61168555
12SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.57224465
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34070527
14CLOCK_20551151_ChIP-Seq_293T_Human2.33783541
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.33560505
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32841341
17GATA1_22025678_ChIP-Seq_K562_Human2.18621630
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.16541225
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.14534510
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.07724107
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06073248
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06050254
23ZNF263_19887448_ChIP-Seq_K562_Human2.03316561
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.02881865
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00802718
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.00327271
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97148771
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96629036
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95934786
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95837470
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94362888
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92787141
33AR_21909140_ChIP-Seq_LNCAP_Human1.89858336
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89048359
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88318304
36DROSHA_22980978_ChIP-Seq_HELA_Human1.86894529
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86467229
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.84871022
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.84534596
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82854780
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82182054
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79241482
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79241482
44* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77825434
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74200406
46BRD4_25478319_ChIP-Seq_HGPS_Human1.73818763
47TFEB_21752829_ChIP-Seq_HELA_Human1.72046285
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71904006
49* TAF15_26573619_Chip-Seq_HEK293_Human1.68371019
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67349056
51REST_21632747_ChIP-Seq_MESCs_Mouse1.66608413
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65027628
53JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63020520
54ATF3_27146783_Chip-Seq_COLON_Human1.62734576
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62229209
56SOX2_20726797_ChIP-Seq_SW620_Human1.61626027
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.58887352
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57998157
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57074035
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.56572728
61* CJUN_26792858_Chip-Seq_BT549_Human1.53367920
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50695761
63SMAD4_21799915_ChIP-Seq_A2780_Human1.50272100
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46056971
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45581924
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45107124
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.44993613
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.43511190
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43446880
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42254906
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41872114
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39508019
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39508019
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39033321
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38922200
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38359565
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38198925
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.37686052
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.36912594
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36638553
81* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36042657
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35392932
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.34048731
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34007804
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32764359
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32321345
87P300_19829295_ChIP-Seq_ESCs_Human1.30359833
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.30207000
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.29201002
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28796818
91AR_21572438_ChIP-Seq_LNCaP_Human1.28316692
92VDR_22108803_ChIP-Seq_LS180_Human1.28095151
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27485912
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27461505
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26928468
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.25642987
97* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24524516
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23902120
99AR_25329375_ChIP-Seq_VCAP_Human1.23648907
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22345651
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.21224014
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19035466
103* IRF8_27001747_Chip-Seq_BMDM_Mouse1.18740115
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18579584
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18301656
106* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18162058
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.17578143
108* SPI1_23127762_ChIP-Seq_K562_Human1.17109193
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16509019
110RACK7_27058665_Chip-Seq_MCF-7_Human1.14898753
111* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14817085
112EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14698230
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.13775141
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.13552466
115* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13530724
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11775306
117TBX20_22080862_ChIP-Seq_HEART_Mouse1.11755222
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.11755222
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11577374
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11488490
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.11317452
122* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10276685
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09221407
124* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08899927
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08681954
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08591333
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08508666
128RXR_22108803_ChIP-Seq_LS180_Human1.08310160
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07157767
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06739939
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06459192
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05570934
133ER_23166858_ChIP-Seq_MCF-7_Human1.05131442
134AHR_22903824_ChIP-Seq_MCF-7_Human1.05005554
135GATA2_21666600_ChIP-Seq_HMVEC_Human1.04863303
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04613860
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.04092927
138PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03951881
139SMAD_19615063_ChIP-ChIP_OVARY_Human1.03041546
140MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02786297
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02510217
142IRF8_22096565_ChIP-ChIP_GC-B_Human1.02413992
143NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00641059
144GATA1_19941826_ChIP-Seq_K562_Human1.00580455
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00479606
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99968249
147* RXR_22158963_ChIP-Seq_LIVER_Mouse0.99689782
148TP53_16413492_ChIP-PET_HCT116_Human0.98813623
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.98771065
150TP53_18474530_ChIP-ChIP_U2OS_Human0.98106949
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97787656
152STAT3_23295773_ChIP-Seq_U87_Human0.97764539
153IGF1R_20145208_ChIP-Seq_DFB_Human0.97740542
154BCAT_22108803_ChIP-Seq_LS180_Human0.97384646
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96321796
156GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96290884
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95472160
158CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95208562
159UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94734486
160THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94718211
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94348015
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93069676
163VDR_24787735_ChIP-Seq_THP-1_Human0.92233846
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91650623
165PU_27001747_Chip-Seq_BMDM_Mouse0.90620778
166FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90536677
167TCF4_23295773_ChIP-Seq_U87_Human0.90127726
168NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89942568
169GATA2_19941826_ChIP-Seq_K562_Human0.89868882
170MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88423318
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88086081
172ERG_21242973_ChIP-ChIP_JURKAT_Human0.87950415
173TP53_22127205_ChIP-Seq_IMR90_Human0.87778325
174P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86775935
175LXR_22158963_ChIP-Seq_LIVER_Mouse0.85527055
176SMAD3_21741376_ChIP-Seq_HESCs_Human0.83519151
177NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82930889
178NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81158694
179KDM2B_26808549_Chip-Seq_REH_Human0.81056752
180AR_19668381_ChIP-Seq_PC3_Human0.81031972
181ESR2_21235772_ChIP-Seq_MCF-7_Human0.80085165
182SMAD4_21741376_ChIP-Seq_HESCs_Human0.79399979
183TCF4_22108803_ChIP-Seq_LS180_Human0.78878551
184NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78615857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.22688175
2MP0004859_abnormal_synaptic_plasticity4.03849575
3MP0003950_abnormal_plasma_membrane3.66626124
4MP0003880_abnormal_central_pattern3.57887858
5MP0005058_abnormal_lysosome_morphology3.00006448
6MP0003566_abnormal_cell_adhesion2.92228180
7MP0002837_dystrophic_cardiac_calcinosis2.84611002
8MP0003635_abnormal_synaptic_transmissio2.59179311
9MP0003705_abnormal_hypodermis_morpholog2.57548368
10* MP0003191_abnormal_cellular_cholesterol2.53082731
11MP0002064_seizures2.51240602
12MP0009745_abnormal_behavioral_response2.43442441
13MP0010234_abnormal_vibrissa_follicle2.41993481
14MP0009046_muscle_twitch2.38796107
15MP0003656_abnormal_erythrocyte_physiolo2.37972034
16MP0004043_abnormal_pH_regulation2.29942162
17MP0005257_abnormal_intraocular_pressure2.28476521
18MP0008438_abnormal_cutaneous_collagen2.22284619
19MP0010352_gastrointestinal_tract_polyps2.19495490
20MP0003172_abnormal_lysosome_physiology2.17113071
21MP0003091_abnormal_cell_migration2.17026627
22MP0000751_myopathy2.15599198
23MP0003300_gastrointestinal_ulcer2.12590249
24MP0003195_calcinosis2.10914996
25MP0004270_analgesia2.06259058
26MP0003646_muscle_fatigue2.06100985
27MP0005023_abnormal_wound_healing2.06074073
28MP0002063_abnormal_learning/memory/cond2.03667930
29MP0003690_abnormal_glial_cell2.01412160
30MP0001968_abnormal_touch/_nociception2.00381659
31MP0003806_abnormal_nucleotide_metabolis1.97311095
32MP0005451_abnormal_body_composition1.95769664
33MP0004510_myositis1.94550219
34MP0003329_amyloid_beta_deposits1.89269566
35MP0002272_abnormal_nervous_system1.85537728
36MP0001501_abnormal_sleep_pattern1.83901054
37MP0003453_abnormal_keratinocyte_physiol1.83783548
38MP0002736_abnormal_nociception_after1.83458473
39MP0002572_abnormal_emotion/affect_behav1.82532667
40MP0000604_amyloidosis1.81948958
41MP0001853_heart_inflammation1.77082771
42MP0000920_abnormal_myelination1.75330437
43MP0005623_abnormal_meninges_morphology1.70139013
44MP0002735_abnormal_chemical_nociception1.69239647
45MP0004484_altered_response_of1.68771512
46MP0004215_abnormal_myocardial_fiber1.67562644
47MP0005360_urolithiasis1.66312147
48MP0004272_abnormal_basement_membrane1.64634706
49MP0004130_abnormal_muscle_cell1.63392539
50MP0004036_abnormal_muscle_relaxation1.61440265
51MP0001440_abnormal_grooming_behavior1.60970825
52MP0000858_altered_metastatic_potential1.60411436
53MP0004084_abnormal_cardiac_muscle1.57133607
54MP0002822_catalepsy1.55713290
55MP0002998_abnormal_bone_remodeling1.55288168
56MP0008260_abnormal_autophagy1.51035762
57MP0005164_abnormal_response_to1.49007565
58MP0003075_altered_response_to1.48661752
59MP0001486_abnormal_startle_reflex1.48005147
60MP0001765_abnormal_ion_homeostasis1.47630255
61MP0002067_abnormal_sensory_capabilities1.47595768
62MP0002148_abnormal_hypersensitivity_rea1.46651237
63MP0003828_pulmonary_edema1.46226239
64MP0003448_altered_tumor_morphology1.42321170
65MP0003879_abnormal_hair_cell1.42162912
66MP0003633_abnormal_nervous_system1.41478605
67MP0009780_abnormal_chondrocyte_physiolo1.41277423
68MP0002734_abnormal_mechanical_nocicepti1.39349671
69MP0006054_spinal_hemorrhage1.39205399
70MP0004233_abnormal_muscle_weight1.38215402
71MP0003279_aneurysm1.34482832
72MP0005332_abnormal_amino_acid1.34414548
73MP0002896_abnormal_bone_mineralization1.32692472
74MP0001970_abnormal_pain_threshold1.30418352
75MP0004947_skin_inflammation1.29935201
76MP0010386_abnormal_urinary_bladder1.27650821
77MP0005386_behavior/neurological_phenoty1.27077321
78MP0004924_abnormal_behavior1.27077321
79* MP0002419_abnormal_innate_immunity1.26706605
80MP0005535_abnormal_body_temperature1.26298757
81MP0003436_decreased_susceptibility_to1.25534308
82MP0002090_abnormal_vision1.23353422
83MP0002909_abnormal_adrenal_gland1.22524508
84MP0002733_abnormal_thermal_nociception1.21992121
85MP0005167_abnormal_blood-brain_barrier1.20901966
86MP0008569_lethality_at_weaning1.19855325
87MP0005464_abnormal_platelet_physiology1.18763750
88MP0006082_CNS_inflammation1.18246353
89MP0002972_abnormal_cardiac_muscle1.17347417
90MP0002229_neurodegeneration1.13506338
91MP0001905_abnormal_dopamine_level1.10010346
92MP0004858_abnormal_nervous_system1.08542558
93MP0001533_abnormal_skeleton_physiology1.08467889
94MP0003631_nervous_system_phenotype1.08037175
95MP0004142_abnormal_muscle_tone1.07432663
96MP0008874_decreased_physiological_sensi1.07322875
97MP0000749_muscle_degeneration1.06912412
98MP0005584_abnormal_enzyme/coenzyme_acti1.06080870
99MP0003634_abnormal_glial_cell1.05285558
100MP0010678_abnormal_skin_adnexa1.05066452
101MP0005330_cardiomyopathy1.04398465
102MP0002060_abnormal_skin_morphology1.04368093
103MP0003303_peritoneal_inflammation1.03027457
104MP0005166_decreased_susceptibility_to1.02517680
105MP0000230_abnormal_systemic_arterial1.01793580
106MP0000747_muscle_weakness0.99587444
107MP0002066_abnormal_motor_capabilities/c0.98540329
108MP0009840_abnormal_foam_cell0.98213661
109MP0009785_altered_susceptibility_to0.97895000
110MP0001542_abnormal_bone_strength0.97863295
111MP0004085_abnormal_heartbeat0.97151203
112MP0006036_abnormal_mitochondrial_physio0.96278793
113MP0001529_abnormal_vocalization0.96268459
114MP0002139_abnormal_hepatobiliary_system0.95590625
115MP0005310_abnormal_salivary_gland0.93788920
116MP0001849_ear_inflammation0.93557565
117* MP0008875_abnormal_xenobiotic_pharmacok0.92097331
118MP0005620_abnormal_muscle_contractility0.91923251
119MP0009643_abnormal_urine_homeostasis0.90353529
120MP0001216_abnormal_epidermal_layer0.89186513
121MP0002876_abnormal_thyroid_physiology0.89107007
122MP0004885_abnormal_endolymph0.88177853
123MP0000343_altered_response_to0.87927300
124MP0001243_abnormal_dermal_layer0.87039547
125MP0005621_abnormal_cell_physiology0.86799280
126MP0008775_abnormal_heart_ventricle0.86360761
127MP0005165_increased_susceptibility_to0.86225441
128MP0005595_abnormal_vascular_smooth0.85546323
129MP0001756_abnormal_urination0.84175038
130MP0005636_abnormal_mineral_homeostasis0.83611408
131MP0004883_abnormal_blood_vessel0.83472696
132MP0004019_abnormal_vitamin_homeostasis0.82909824
133MP0003183_abnormal_peptide_metabolism0.82833052
134MP0001958_emphysema0.82805277
135MP0002332_abnormal_exercise_endurance0.82006254
136MP0005197_abnormal_uvea_morphology0.81746435
137MP0001984_abnormal_olfaction0.81653922
138MP0005076_abnormal_cell_differentiation0.79993748
139MP0003795_abnormal_bone_structure0.79567222
140MP0003137_abnormal_impulse_conducting0.77676642
141MP0001502_abnormal_circadian_rhythm0.77641337
142MP0004811_abnormal_neuron_physiology0.77290413
143MP0002557_abnormal_social/conspecific_i0.77274694
144MP0005646_abnormal_pituitary_gland0.77006769
145MP0005171_absent_coat_pigmentation0.76038737
146MP0004185_abnormal_adipocyte_glucose0.75615040
147MP0000733_abnormal_muscle_development0.75601363
148MP0010368_abnormal_lymphatic_system0.74800561
149MP0000003_abnormal_adipose_tissue0.74608108
150MP0003045_fibrosis0.74272812
151MP0003632_abnormal_nervous_system0.74083153
152MP0000767_abnormal_smooth_muscle0.73224894
153MP0005385_cardiovascular_system_phenoty0.72923204
154MP0001544_abnormal_cardiovascular_syste0.72923204
155MP0005083_abnormal_biliary_tract0.72765242
156MP0001915_intracranial_hemorrhage0.72176282
157MP0001545_abnormal_hematopoietic_system0.71836736
158MP0005397_hematopoietic_system_phenotyp0.71836736
159MP0008469_abnormal_protein_level0.70970014
160MP0000681_abnormal_thyroid_gland0.70961374
161MP0000249_abnormal_blood_vessel0.69688109
162MP0001348_abnormal_lacrimal_gland0.69206795
163MP0005365_abnormal_bile_salt0.68879907
164MP0001845_abnormal_inflammatory_respons0.68593485
165MP0000013_abnormal_adipose_tissue0.67993045
166MP0010307_abnormal_tumor_latency0.65875672
167MP0009764_decreased_sensitivity_to0.65146534
168MP0005025_abnormal_response_to0.64555715
169MP0000358_abnormal_cell_content/0.62574296
170MP0002269_muscular_atrophy0.62334839
171MP0000371_diluted_coat_color0.62210201
172MP0005384_cellular_phenotype0.62018508

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.65542993
2Increased cerebral lipofuscin (HP:0011813)3.99528241
3Increased circulating renin level (HP:0000848)3.78155646
4Myocardial infarction (HP:0001658)3.75840934
5Osteolytic defects of the hand bones (HP:0009699)3.69752368
6Osteolytic defects of the phalanges of the hand (HP:0009771)3.69752368
7Vacuolated lymphocytes (HP:0001922)3.43802488
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.38246964
9Vertebral compression fractures (HP:0002953)3.34130855
10Metabolic alkalosis (HP:0200114)3.20904691
11Myokymia (HP:0002411)3.15063757
12Focal seizures (HP:0007359)3.11830204
13Hyperactive renin-angiotensin system (HP:0000841)3.11445225
14Dysostosis multiplex (HP:0000943)3.09641379
15Premature rupture of membranes (HP:0001788)3.07798927
16Atonic seizures (HP:0010819)3.06039280
17Hypokalemic alkalosis (HP:0001949)2.98377540
18Axonal loss (HP:0003447)2.97677481
19Nuclear cataract (HP:0100018)2.97394813
20Neurofibrillary tangles (HP:0002185)2.96926247
21Supranuclear gaze palsy (HP:0000605)2.94624097
22Visual hallucinations (HP:0002367)2.89151258
23Short nail (HP:0001799)2.87299182
24Gout (HP:0001997)2.87212448
25Hypomagnesemia (HP:0002917)2.85550473
26Apathy (HP:0000741)2.84400143
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.80532192
28Epileptic encephalopathy (HP:0200134)2.67487797
29Diminished motivation (HP:0000745)2.66436546
30Distal lower limb muscle weakness (HP:0009053)2.65990048
31Hyperaldosteronism (HP:0000859)2.65142147
32Absence seizures (HP:0002121)2.64920765
33Dialeptic seizures (HP:0011146)2.64755806
34Ketoacidosis (HP:0001993)2.62875076
35Cerebral inclusion bodies (HP:0100314)2.62544140
36Hyperventilation (HP:0002883)2.61390535
37Distal lower limb amyotrophy (HP:0008944)2.59383818
38Upper motor neuron abnormality (HP:0002127)2.56397020
39Tetraparesis (HP:0002273)2.55917193
40Sudden death (HP:0001699)2.55169210
41Abnormal eating behavior (HP:0100738)2.54553905
42Arterial tortuosity (HP:0005116)2.53894572
43Urinary glycosaminoglycan excretion (HP:0003541)2.53672574
44Mucopolysacchariduria (HP:0008155)2.53672574
45Pheochromocytoma (HP:0002666)2.52553086
46Polyuria (HP:0000103)2.51653068
47Loss of speech (HP:0002371)2.51382747
48Febrile seizures (HP:0002373)2.51037794
49Generalized tonic-clonic seizures (HP:0002069)2.48654057
50Abnormality of macrophages (HP:0004311)2.48029044
51Skin nodule (HP:0200036)2.47766216
52Abnormality of renin-angiotensin system (HP:0000847)2.46775532
53Tetany (HP:0001281)2.45585236
54Mitral stenosis (HP:0001718)2.44119893
55Polydipsia (HP:0001959)2.41704535
56Abnormal drinking behavior (HP:0030082)2.41704535
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41702411
58Abnormality of polysaccharide metabolism (HP:0011012)2.41702411
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41702411
60Disinhibition (HP:0000734)2.41191510
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.40412305
62Abnormality of glycolipid metabolism (HP:0010969)2.40412305
63Abnormality of liposaccharide metabolism (HP:0010968)2.40412305
64Abnormal urine output (HP:0012590)2.39665516
65Interstitial pulmonary disease (HP:0006530)2.39478982
66Abnormality of magnesium homeostasis (HP:0004921)2.37188512
67Abnormality of chloride homeostasis (HP:0011422)2.36758771
68Neuronal loss in central nervous system (HP:0002529)2.34328815
69Asymmetric septal hypertrophy (HP:0001670)2.31270430
70Vascular tortuosity (HP:0004948)2.30290723
71Syncope (HP:0001279)2.29000727
72Neuroendocrine neoplasm (HP:0100634)2.28117961
73Cardiovascular calcification (HP:0011915)2.28047693
74Polyphagia (HP:0002591)2.27912572
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.27718907
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27718907
77Acute encephalopathy (HP:0006846)2.25172124
78Spondylolisthesis (HP:0003302)2.24381706
79Cerebral hemorrhage (HP:0001342)2.24319939
80Abnormal mitochondria in muscle tissue (HP:0008316)2.24099657
81Protrusio acetabuli (HP:0003179)2.23837297
82Mutism (HP:0002300)2.23420827
83Acute necrotizing encephalopathy (HP:0006965)2.21084366
84Progressive inability to walk (HP:0002505)2.20869512
85Abnormality of renal excretion (HP:0011036)2.19785988
86Vascular calcification (HP:0004934)2.19181798
87Distal upper limb amyotrophy (HP:0007149)2.18921598
88Upper limb amyotrophy (HP:0009129)2.18921598
89Reduced subcutaneous adipose tissue (HP:0003758)2.16992271
90Hypokinesia (HP:0002375)2.14649699
91Lower limb amyotrophy (HP:0007210)2.12741729
92Global brain atrophy (HP:0002283)2.12475122
93J-shaped sella turcica (HP:0002680)2.11816308
94Dysmetria (HP:0001310)2.11400250
95Ketosis (HP:0001946)2.10559840
96Cervical subluxation (HP:0003308)2.07493357
97Xanthomatosis (HP:0000991)2.07364551
98Bone pain (HP:0002653)2.07341727
99Increased purine levels (HP:0004368)2.06893551
100Hyperuricemia (HP:0002149)2.06893551
101Hepatocellular necrosis (HP:0001404)2.03843959
102Atrial fibrillation (HP:0005110)2.03833667
103Hepatosplenomegaly (HP:0001433)2.03501154
104Sensorimotor neuropathy (HP:0007141)2.01838672
105Calf muscle hypertrophy (HP:0008981)2.01640234
106Exercise-induced muscle cramps (HP:0003710)2.01319297
107Diplopia (HP:0000651)2.01193530
108Abnormality of binocular vision (HP:0011514)2.01193530
109Multiple lipomas (HP:0001012)2.00538066
110Status epilepticus (HP:0002133)2.00527010
111Atrophic scars (HP:0001075)1.99197496
112Achilles tendon contracture (HP:0001771)1.98316557
113Progressive macrocephaly (HP:0004481)1.97525027
114Renal salt wasting (HP:0000127)1.96651951
115Insomnia (HP:0100785)1.95282077
116Mitochondrial inheritance (HP:0001427)1.94553341
117Recurrent abscess formation (HP:0002722)1.93596406
118Anxiety (HP:0000739)1.92933806
119Abnormality of the corticospinal tract (HP:0002492)1.92775935
120Decreased circulating renin level (HP:0003351)1.92182450
121Muscle hypertrophy of the lower extremities (HP:0008968)1.91840018
122Primary atrial arrhythmia (HP:0001692)1.90820641
123Exercise-induced myalgia (HP:0003738)1.90258215
124Abnormality of the distal phalanges of the toes (HP:0010182)1.90134496
125Progressive neurologic deterioration (HP:0002344)1.88635592
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.88122367
127Hepatic necrosis (HP:0002605)1.88072693
128Systemic lupus erythematosus (HP:0002725)1.87979151
129Cardiomegaly (HP:0001640)1.87172084
130Action tremor (HP:0002345)1.86888441
131Glucose intolerance (HP:0000833)1.86490126
132Abnormality of fatty-acid metabolism (HP:0004359)1.86011119
133Psychosis (HP:0000709)1.85579524
134Dysdiadochokinesis (HP:0002075)1.84408410
135Postural instability (HP:0002172)1.84011387
136Broad-based gait (HP:0002136)1.83118734
137Increased connective tissue (HP:0009025)1.81778495
138Pathologic fracture (HP:0002756)1.79549492
139Wormian bones (HP:0002645)1.79145701
140Orthostatic hypotension (HP:0001278)1.78663114
141Abnormality of the Achilles tendon (HP:0005109)1.78303559
142Abnormality of purine metabolism (HP:0004352)1.78098501
143Impaired social interactions (HP:0000735)1.77990442
144Abnormal social behavior (HP:0012433)1.77990442
145Recurrent gram-negative bacterial infections (HP:0005420)1.76982604
146Progressive cerebellar ataxia (HP:0002073)1.76636025
147Termporal pattern (HP:0011008)1.76599318
148Spinal rigidity (HP:0003306)1.74680146
149Hand muscle atrophy (HP:0009130)1.74656097
150Subacute progressive viral hepatitis (HP:0006572)1.72967778
151Hyperacusis (HP:0010780)1.72420543
152Prolonged neonatal jaundice (HP:0006579)1.71252972
153Upper limb muscle weakness (HP:0003484)1.69697632
154Ovoid vertebral bodies (HP:0003300)1.69511160
155Scanning speech (HP:0002168)1.68310852
156Neoplasm of head and neck (HP:0012288)1.68308640
157Esophageal neoplasm (HP:0100751)1.68308640
158Thick nail (HP:0001805)1.67578995
159Protuberant abdomen (HP:0001538)1.67226411
160Personality changes (HP:0000751)1.64379549
161Centrally nucleated skeletal muscle fibers (HP:0003687)1.63174713
162Insidious onset (HP:0003587)1.62203597
163Abnormal glucose tolerance (HP:0001952)1.61371681
164Autoimmune thrombocytopenia (HP:0001973)1.60381907
165Dementia (HP:0000726)1.60213350
166Focal segmental glomerulosclerosis (HP:0000097)1.60058645
167Rough bone trabeculation (HP:0100670)1.59682522
168Fragile skin (HP:0001030)1.59649687
169Broad face (HP:0000283)1.57976046
170Amyloidosis (HP:0011034)1.57710257
171Spinal muscular atrophy (HP:0007269)1.57383677
172Generalized amyotrophy (HP:0003700)1.56288354
173Ankle contracture (HP:0006466)1.55977310
174Recurrent bacterial skin infections (HP:0005406)1.55475433
175Abnormality of the periventricular white matter (HP:0002518)1.55117105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.47221995
2IRAK33.71212718
3RIPK43.64548847
4EPHA23.42696972
5EPHA43.39543551
6OXSR13.30753338
7NTRK32.84541190
8MAP3K92.70931856
9LIMK12.53663438
10ERBB42.43220100
11MET2.42127297
12NME22.37147627
13MAP3K122.32663971
14TESK12.29920485
15PAK42.17386139
16WNK42.15985544
17DAPK22.13298505
18WNK32.09996832
19MAP3K42.07048607
20LATS22.01315305
21KSR21.97553692
22PTK21.96618871
23MAP2K71.89024301
24ARAF1.86551110
25MAP3K131.73645183
26CDK191.73365753
27MAP3K31.71981939
28STK391.71855150
29GRK71.67131466
30PBK1.67127438
31MAP2K41.66831852
32NEK91.61438406
33CAMKK21.59676469
34EIF2AK11.58725116
35CASK1.55464962
36FES1.53587997
37PDGFRA1.51131366
38MST41.50931285
39TAOK21.49409347
40NTRK11.47286694
41MINK11.44614699
42RIPK11.44258025
43TNIK1.43452051
44STK101.41517851
45TRPM71.39205483
46BMPR21.37455709
47PAK61.35748793
48PLK21.32728264
49CAMKK11.28579252
50DAPK11.22626089
51MAP2K31.20476579
52CAMK2A1.17035618
53GRK51.16986748
54SGK4941.15359435
55SGK2231.15359435
56KIT1.14054977
57CAMK2D1.13844643
58MYLK1.11219116
59LMTK21.09877999
60ICK1.09869464
61PINK11.08544281
62TTN1.07585236
63FGR1.07190535
64ERN11.06445091
65MOS1.05902761
66EIF2AK31.05383226
67PDPK11.05086969
68MAP3K141.04257209
69PDK41.01989692
70PDK31.01989692
71MUSK1.01077462
72CDK51.00476112
73STK380.99676526
74NEK10.97903266
75PDK20.96632051
76SIK30.96015588
77MAP3K80.95784371
78CAMK2B0.95763808
79PHKG20.95725436
80PHKG10.95725436
81PTK2B0.95273563
82PDK10.94917135
83PRKG20.94898474
84DDR20.92479952
85TESK20.89240477
86SGK20.86462116
87WNK10.85645407
88MAP3K10.84084872
89MAP3K20.83872602
90BMX0.81435523
91PAK20.81414588
92SGK30.81209946
93PRKCE0.80053845
94BUB10.73242579
95EPHB10.72735701
96PRKCG0.72706010
97SGK10.72432698
98PRKCH0.71517780
99CAMK10.71187114
100CAMK2G0.70580940
101RAF10.70220298
102PRPF4B0.69094843
103ZAP700.68241098
104BRSK10.66736860
105SCYL20.66209946
106DMPK0.65060075
107DAPK30.63368357
108ERBB30.62701893
109PAK30.62512524
110LATS10.60858247
111BCKDK0.60792795
112TRIB30.59253738
113RET0.58664233
114TAOK30.58614253
115PRKCQ0.57399761
116SIK10.57052032
117MAPK120.55865291
118FYN0.54563758
119MAP3K70.54329446
120NTRK20.53724851
121TGFBR20.53137964
122PIM20.52370244
123PKN10.51824477
124BLK0.51764645
125MAP3K60.51499357
126KSR10.51194107
127SYK0.50542348
128TBK10.50407894
129CDC42BPA0.50065796
130TYK20.49072932
131PDGFRB0.48391706
132MAPKAPK50.47518493
133CAMK40.47406055
134BRAF0.46955112
135ABL20.45442538
136ROCK20.43792402
137EPHB20.43791167
138ROCK10.42769067
139MELK0.42633693
140PAK10.41834733
141MAP3K110.41559043
142CDK80.41443886
143PRKACA0.40028558
144PRKD10.39858681
145CDK180.39051052
146TIE10.38608935
147JAK20.37932646
148MAP3K50.37587277
149MAP2K10.37232341
150PRKCD0.36810636
151PRKCA0.36732643
152CDK120.36655386
153PRKACG0.36090117
154JAK10.36045099
155PRKACB0.35985345
156NEK60.34710413
157STK30.34689275
158CDK150.34448619
159CSNK1G20.34342417
160STK240.33881395
161CDK140.31739796
162RPS6KA20.31294913
163CLK10.29995181

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.32838351
2Collecting duct acid secretion_Homo sapiens_hsa049663.09975443
3Synaptic vesicle cycle_Homo sapiens_hsa047212.67182206
4Nicotine addiction_Homo sapiens_hsa050332.23899478
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97706962
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.96704251
7Oxidative phosphorylation_Homo sapiens_hsa001901.94123755
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87101820
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86013763
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.84430257
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76532879
12Lysosome_Homo sapiens_hsa041421.71253637
13GABAergic synapse_Homo sapiens_hsa047271.70142333
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69334153
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69034835
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65549482
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63160108
18Circadian entrainment_Homo sapiens_hsa047131.61442146
19Butanoate metabolism_Homo sapiens_hsa006501.61262512
20Salmonella infection_Homo sapiens_hsa051321.58365284
21Galactose metabolism_Homo sapiens_hsa000521.57869371
22Morphine addiction_Homo sapiens_hsa050321.56264071
23Vibrio cholerae infection_Homo sapiens_hsa051101.50959623
24Long-term potentiation_Homo sapiens_hsa047201.48705122
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46944727
26Salivary secretion_Homo sapiens_hsa049701.45017211
27Glutamatergic synapse_Homo sapiens_hsa047241.44564724
28Bladder cancer_Homo sapiens_hsa052191.43727040
29Gastric acid secretion_Homo sapiens_hsa049711.43416379
30Olfactory transduction_Homo sapiens_hsa047401.41535981
31Proteoglycans in cancer_Homo sapiens_hsa052051.36816668
32Pentose phosphate pathway_Homo sapiens_hsa000301.35870476
33Cardiac muscle contraction_Homo sapiens_hsa042601.35791496
34Alzheimers disease_Homo sapiens_hsa050101.33582898
35Renin secretion_Homo sapiens_hsa049241.32412025
36Shigellosis_Homo sapiens_hsa051311.31939889
37Rheumatoid arthritis_Homo sapiens_hsa053231.30397197
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30333563
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29734105
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29385811
41Propanoate metabolism_Homo sapiens_hsa006401.27350541
42Parkinsons disease_Homo sapiens_hsa050121.25168748
43Vitamin B6 metabolism_Homo sapiens_hsa007501.21983425
44Malaria_Homo sapiens_hsa051441.20041013
45Amphetamine addiction_Homo sapiens_hsa050311.19884063
46Pertussis_Homo sapiens_hsa051331.19232763
47Prion diseases_Homo sapiens_hsa050201.19155850
48Focal adhesion_Homo sapiens_hsa045101.19041845
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.16228041
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.15240963
51TNF signaling pathway_Homo sapiens_hsa046681.12990760
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11729485
53Phagosome_Homo sapiens_hsa041451.11678899
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11103098
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10120870
56Dopaminergic synapse_Homo sapiens_hsa047281.07950257
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07791971
58Insulin secretion_Homo sapiens_hsa049111.06571224
59Calcium signaling pathway_Homo sapiens_hsa040201.06033682
60Other glycan degradation_Homo sapiens_hsa005111.04596449
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03889032
62Pyruvate metabolism_Homo sapiens_hsa006201.03566971
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03246807
64Legionellosis_Homo sapiens_hsa051341.02152272
65Amoebiasis_Homo sapiens_hsa051461.00358840
66Taste transduction_Homo sapiens_hsa047421.00246337
67ECM-receptor interaction_Homo sapiens_hsa045121.00050269
68Serotonergic synapse_Homo sapiens_hsa047260.99795001
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98034416
70Long-term depression_Homo sapiens_hsa047300.97636841
71Fructose and mannose metabolism_Homo sapiens_hsa000510.97250576
72Fatty acid degradation_Homo sapiens_hsa000710.96436007
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96414642
74Cholinergic synapse_Homo sapiens_hsa047250.95949764
75Toxoplasmosis_Homo sapiens_hsa051450.95775144
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95217440
77Fatty acid elongation_Homo sapiens_hsa000620.94674770
78Renal cell carcinoma_Homo sapiens_hsa052110.94248505
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.94067469
80Apoptosis_Homo sapiens_hsa042100.92853579
81Pancreatic cancer_Homo sapiens_hsa052120.92388859
82Adherens junction_Homo sapiens_hsa045200.91752965
83Oxytocin signaling pathway_Homo sapiens_hsa049210.91302515
84Leishmaniasis_Homo sapiens_hsa051400.90899679
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90501116
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88067483
87Endocytosis_Homo sapiens_hsa041440.88035868
88Dilated cardiomyopathy_Homo sapiens_hsa054140.86456683
89Fatty acid metabolism_Homo sapiens_hsa012120.85826677
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84993958
91Complement and coagulation cascades_Homo sapiens_hsa046100.84949676
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81191047
93Peroxisome_Homo sapiens_hsa041460.79536353
94Chronic myeloid leukemia_Homo sapiens_hsa052200.79253603
95Small cell lung cancer_Homo sapiens_hsa052220.78642490
96N-Glycan biosynthesis_Homo sapiens_hsa005100.78083353
97* Bile secretion_Homo sapiens_hsa049760.77328288
98cAMP signaling pathway_Homo sapiens_hsa040240.76038738
99Hepatitis C_Homo sapiens_hsa051600.74024338
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73720798
101HIF-1 signaling pathway_Homo sapiens_hsa040660.73503936
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73474802
103GnRH signaling pathway_Homo sapiens_hsa049120.72227978
104Influenza A_Homo sapiens_hsa051640.71831284
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70045584
106Cocaine addiction_Homo sapiens_hsa050300.69497111
107Type II diabetes mellitus_Homo sapiens_hsa049300.69300033
108Tuberculosis_Homo sapiens_hsa051520.68811552
109Pancreatic secretion_Homo sapiens_hsa049720.68109408
110Carbon metabolism_Homo sapiens_hsa012000.67999911
111Thyroid cancer_Homo sapiens_hsa052160.67120802
112Arginine biosynthesis_Homo sapiens_hsa002200.66365672
113Mineral absorption_Homo sapiens_hsa049780.64674193
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64003661
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.63815147
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62723133
117Viral myocarditis_Homo sapiens_hsa054160.62635468
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62385560
119Nitrogen metabolism_Homo sapiens_hsa009100.62286665
120Proteasome_Homo sapiens_hsa030500.62156297
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61662167
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58402547
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.55655089
124Huntingtons disease_Homo sapiens_hsa050160.55536273
125Non-small cell lung cancer_Homo sapiens_hsa052230.55373926
126Gap junction_Homo sapiens_hsa045400.54699852
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54509677
128Antigen processing and presentation_Homo sapiens_hsa046120.54282762
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.54241704
130Hepatitis B_Homo sapiens_hsa051610.53517087
131beta-Alanine metabolism_Homo sapiens_hsa004100.52858922
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52205101
133PPAR signaling pathway_Homo sapiens_hsa033200.51989519
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.51899455
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51714006
136Thyroid hormone synthesis_Homo sapiens_hsa049180.51544139
137Staphylococcus aureus infection_Homo sapiens_hsa051500.50649272
138Glutathione metabolism_Homo sapiens_hsa004800.50378513
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49578873
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48596071
141Sphingolipid metabolism_Homo sapiens_hsa006000.48441297
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47803783
143Sulfur metabolism_Homo sapiens_hsa009200.46751190
144VEGF signaling pathway_Homo sapiens_hsa043700.44211645
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44071331
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.44054261
147African trypanosomiasis_Homo sapiens_hsa051430.43563593
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42845541
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41809941
150Inositol phosphate metabolism_Homo sapiens_hsa005620.41771148
151Estrogen signaling pathway_Homo sapiens_hsa049150.41303943
152ErbB signaling pathway_Homo sapiens_hsa040120.40752283
153Steroid biosynthesis_Homo sapiens_hsa001000.39609044
154Starch and sucrose metabolism_Homo sapiens_hsa005000.39251212
155Hematopoietic cell lineage_Homo sapiens_hsa046400.38796771
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.38196860
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38151549
158Osteoclast differentiation_Homo sapiens_hsa043800.37881011
159Glioma_Homo sapiens_hsa052140.37804440
160Ovarian steroidogenesis_Homo sapiens_hsa049130.36857863
161MicroRNAs in cancer_Homo sapiens_hsa052060.35981222
162Tryptophan metabolism_Homo sapiens_hsa003800.35923198

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »