NCF1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The neutrophil cytosolic factor 1 (NCF1) gene encodes the 47 kDa cytosolic subunit of neutrophil NADPH oxidase, which produces superoxide anion. The NCF1 gene is located in close proximity to two highly similar, multi-exon pseudogenes at chromosome 7q11.23, corresponding to this gene record and GeneID:654816. The two pseudogenes contain a dinucleotide deletion (delta-GT) in exon 2 that results in a frameshift and truncation of the open reading frame, and neither pseudogene is likely to express a protein. Recombination events between the pseudogenes and the functional NCF1 gene can inactivate the NCF1 gene and result in chronic granulomatous disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.92495569
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.92495569
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.66349219
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.66349219
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.66349219
6modulation by symbiont of host immune response (GO:0052553)5.66349219
7positive regulation by symbiont of host defense response (GO:0052509)5.66349219
8modulation by symbiont of host defense response (GO:0052031)5.66349219
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.64882863
10positive regulation of gamma-delta T cell activation (GO:0046645)5.50401937
11antigen processing and presentation of endogenous antigen (GO:0019883)5.42802772
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33933536
13neutrophil activation involved in immune response (GO:0002283)5.29905942
14detection of other organism (GO:0098543)5.13183068
15detection of bacterium (GO:0016045)5.06055252
16macrophage activation involved in immune response (GO:0002281)4.91816661
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87469379
18regulation of B cell receptor signaling pathway (GO:0050855)4.84328238
19response to peptidoglycan (GO:0032494)4.81175629
20immunoglobulin mediated immune response (GO:0016064)4.70480439
21negative regulation of interleukin-12 production (GO:0032695)4.49191729
22regulation of interferon-beta biosynthetic process (GO:0045357)4.47374330
23leukocyte aggregation (GO:0070486)4.36652373
24respiratory burst (GO:0045730)4.30120481
25detection of external biotic stimulus (GO:0098581)4.27139514
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15426600
27type I interferon signaling pathway (GO:0060337)4.07977072
28cellular response to type I interferon (GO:0071357)4.07977072
29response to type I interferon (GO:0034340)4.04252279
30neutrophil activation (GO:0042119)4.03504175
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93288900
32regulation of gamma-delta T cell activation (GO:0046643)3.92875671
33B cell receptor signaling pathway (GO:0050853)3.92583290
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.89127892
35response to host immune response (GO:0052572)3.89127892
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.88493600
37detection of molecule of bacterial origin (GO:0032490)3.84790386
38granulocyte activation (GO:0036230)3.82294577
39cellular extravasation (GO:0045123)3.80015470
40leukocyte migration involved in inflammatory response (GO:0002523)3.77775920
41detection of biotic stimulus (GO:0009595)3.72853740
42interferon-gamma-mediated signaling pathway (GO:0060333)3.72248182
43B cell mediated immunity (GO:0019724)3.70776019
44regulation of mast cell degranulation (GO:0043304)3.68389715
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.65190930
46defense response to protozoan (GO:0042832)3.64495529
47myeloid cell activation involved in immune response (GO:0002275)3.64355874
48response to host (GO:0075136)3.54348694
49response to host defenses (GO:0052200)3.54348694
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.54348694
51microglial cell activation (GO:0001774)3.51144853
52negative regulation of leukocyte mediated immunity (GO:0002704)3.49167972
53germinal center formation (GO:0002467)3.49160332
54response to interleukin-15 (GO:0070672)3.48732401
55production of molecular mediator involved in inflammatory response (GO:0002532)3.46380866
56regulation of antigen processing and presentation (GO:0002577)3.40870168
57neutrophil mediated immunity (GO:0002446)3.40089488
58macrophage activation (GO:0042116)3.39602930
59regulation of mast cell activation involved in immune response (GO:0033006)3.37843181
60positive regulation of interferon-alpha production (GO:0032727)3.35942595
61response to muramyl dipeptide (GO:0032495)3.33537340
62negative regulation of T cell mediated immunity (GO:0002710)3.30867887
63positive regulation of mast cell activation (GO:0033005)3.30477924
64lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29955077
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.29545962
66response to protozoan (GO:0001562)3.29380782
67regulation of interferon-alpha production (GO:0032647)3.27316262
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23527474
69cellular response to interleukin-15 (GO:0071350)3.23345616
70positive regulation of B cell differentiation (GO:0045579)3.22095652
71regulation of T cell tolerance induction (GO:0002664)3.20225955
72regulation of gamma-delta T cell differentiation (GO:0045586)3.19974567
73regulation of B cell differentiation (GO:0045577)3.19287603
74regulation of mast cell activation (GO:0033003)3.18106775
75regulation of leukocyte degranulation (GO:0043300)3.17824820
76positive regulation of antigen processing and presentation (GO:0002579)3.16760985
77NIK/NF-kappaB signaling (GO:0038061)3.16744958
78regulation of T-helper 2 cell differentiation (GO:0045628)3.14901299
79negative regulation of phagocytosis (GO:0050765)3.11343375
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07803172
81positive regulation of type 2 immune response (GO:0002830)3.05991093
82negative regulation of cytokine production involved in immune response (GO:0002719)3.04750982
83T-helper 1 type immune response (GO:0042088)3.04086405
84T cell migration (GO:0072678)3.02548764
85positive thymic T cell selection (GO:0045059)3.01766748
86regulation of tolerance induction (GO:0002643)3.00588123
87leukocyte degranulation (GO:0043299)3.00561848
88antigen processing and presentation via MHC class Ib (GO:0002475)2.99941176
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99755566
90regulation of T cell mediated cytotoxicity (GO:0001914)2.95819834
91regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92312143
92myeloid leukocyte mediated immunity (GO:0002444)2.91489078
93negative regulation of innate immune response (GO:0045824)2.91197545
94negative regulation of alpha-beta T cell activation (GO:0046636)2.90731368
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.90104550
96positive regulation of mast cell degranulation (GO:0043306)2.90104550
97myeloid dendritic cell differentiation (GO:0043011)2.87774629
98negative regulation of interleukin-6 production (GO:0032715)2.87552582
99regulation of alpha-beta T cell proliferation (GO:0046640)2.86081086
100hydrogen peroxide biosynthetic process (GO:0050665)2.86067822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.10769345
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.54571289
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.46952084
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57860606
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37574417
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23441930
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.20319796
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19638966
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16889086
10VDR_21846776_ChIP-Seq_THP-1_Human2.98375974
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84854841
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84844889
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79903896
14SPI1_23547873_ChIP-Seq_NB4_Human2.70480012
15MYC_22102868_ChIP-Seq_BL_Human2.68850371
16VDR_24763502_ChIP-Seq_THP-1_Human2.68438544
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60169235
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59349330
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52871053
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49044585
21SPI1_23127762_ChIP-Seq_K562_Human2.48315107
22MAF_26560356_Chip-Seq_TH1_Human2.43546069
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37109396
24RUNX_20019798_ChIP-Seq_JUKART_Human2.34071360
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31715262
26MYB_26560356_Chip-Seq_TH2_Human2.22539629
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.19947694
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18032135
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14957055
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.14222886
31UTX_26944678_Chip-Seq_JUKART_Human2.13990812
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08448485
33SCL_19346495_ChIP-Seq_HPC-7_Human2.05890423
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98735871
35MYB_26560356_Chip-Seq_TH1_Human1.94791625
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93369361
37TCF7_22412390_ChIP-Seq_EML_Mouse1.90247289
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87132891
39MAF_26560356_Chip-Seq_TH2_Human1.81752054
40KDM2B_26808549_Chip-Seq_DND41_Human1.70873349
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70736674
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63512212
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62657683
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62604503
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62533654
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62430912
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62287130
48VDR_24787735_ChIP-Seq_THP-1_Human1.60423972
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56916288
50GATA3_27048872_Chip-Seq_THYMUS_Human1.53360121
51LXR_22292898_ChIP-Seq_THP-1_Human1.53277820
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50418854
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48300364
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47883023
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.45715372
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.44714635
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43689904
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36692348
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34618346
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33973446
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32269326
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.31018353
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30831321
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29242477
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28518679
66BCL6_27268052_Chip-Seq_Bcells_Human1.27995683
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27750161
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27398191
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24521217
70PU_27001747_Chip-Seq_BMDM_Mouse1.24302883
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21863119
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21832583
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21554145
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19642089
75GATA3_26560356_Chip-Seq_TH2_Human1.19401409
76GATA1_22025678_ChIP-Seq_K562_Human1.18997117
77BCOR_27268052_Chip-Seq_Bcells_Human1.17924506
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17634133
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17135052
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16700345
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16063311
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14299353
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13751386
84GATA1_19941826_ChIP-Seq_K562_Human1.10980194
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.05445171
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02386569
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01949503
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95585838
89CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94937615
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93611452
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92988832
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.92961204
93NCOR1_26117541_ChIP-Seq_K562_Human0.91883092
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91697217
95SPI1_20517297_ChIP-Seq_HL60_Human0.87586607
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86436765
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85946495
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.83918148
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.82840710
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79097826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.33075830
2MP0003436_decreased_susceptibility_to4.22775032
3MP0003303_peritoneal_inflammation4.19492693
4MP0001835_abnormal_antigen_presentation3.97663503
5MP0001790_abnormal_immune_system3.37714522
6MP0005387_immune_system_phenotype3.37714522
7MP0005671_abnormal_response_to3.28507470
8MP0009785_altered_susceptibility_to3.19785864
9MP0001800_abnormal_humoral_immune3.18373692
10MP0002419_abnormal_innate_immunity3.16506033
11MP0005000_abnormal_immune_tolerance3.09486484
12MP0000685_abnormal_immune_system3.08459253
13MP0005025_abnormal_response_to3.02351626
14MP0002723_abnormal_immune_serum2.78054936
15MP0002452_abnormal_antigen_presenting2.75643159
16MP0006082_CNS_inflammation2.74734433
17MP0002148_abnormal_hypersensitivity_rea2.67719723
18MP0002420_abnormal_adaptive_immunity2.65302594
19MP0001819_abnormal_immune_cell2.62670497
20MP0003300_gastrointestinal_ulcer2.44510418
21MP0001533_abnormal_skeleton_physiology2.11643024
22MP0003191_abnormal_cellular_cholesterol2.07848587
23MP0003763_abnormal_thymus_physiology2.02683948
24MP0002405_respiratory_system_inflammati2.01207462
25MP0002398_abnormal_bone_marrow1.97221277
26MP0000716_abnormal_immune_system1.96722518
27MP0003172_abnormal_lysosome_physiology1.95823522
28MP0010155_abnormal_intestine_physiology1.91530252
29MP0001845_abnormal_inflammatory_respons1.89829909
30MP0003183_abnormal_peptide_metabolism1.87131978
31MP0005464_abnormal_platelet_physiology1.84212978
32MP0004510_myositis1.80164496
33MP0004947_skin_inflammation1.74295749
34MP0009278_abnormal_bone_marrow1.69434603
35MP0008260_abnormal_autophagy1.66559254
36MP0000689_abnormal_spleen_morphology1.66124131
37MP0005451_abnormal_body_composition1.62941794
38MP0005058_abnormal_lysosome_morphology1.60455294
39MP0009764_decreased_sensitivity_to1.59412355
40MP0005310_abnormal_salivary_gland1.59065922
41MP0008469_abnormal_protein_level1.58610810
42MP0009333_abnormal_splenocyte_physiolog1.56684152
43MP0002722_abnormal_immune_system1.55719317
44MP0002429_abnormal_blood_cell1.55397760
45MP0000465_gastrointestinal_hemorrhage1.43260238
46MP0003075_altered_response_to1.41603344
47MP0002132_abnormal_respiratory_system1.38622365
48MP0003866_abnormal_defecation1.31606304
49MP0003828_pulmonary_edema1.30306553
50MP0000858_altered_metastatic_potential1.28027473
51MP0002138_abnormal_hepatobiliary_system1.26921423
52MP0000703_abnormal_thymus_morphology1.24030689
53MP0002998_abnormal_bone_remodeling1.20258487
54MP0002277_abnormal_respiratory_mucosa1.20008102
55MP0001545_abnormal_hematopoietic_system1.19922702
56MP0005397_hematopoietic_system_phenotyp1.19922702
57MP0002396_abnormal_hematopoietic_system1.19167985
58MP0000343_altered_response_to1.15760472
59MP0004883_abnormal_blood_vessel1.14255762
60MP0003806_abnormal_nucleotide_metabolis1.10821565
61MP0001853_heart_inflammation1.08723262
62MP0005166_decreased_susceptibility_to1.07681749
63MP0001851_eye_inflammation1.06578232
64MP0003690_abnormal_glial_cell1.03152138
65MP0008004_abnormal_stomach_pH1.02349439
66MP0004381_abnormal_hair_follicle0.99338912
67MP0001873_stomach_inflammation0.97061593
68MP0005164_abnormal_response_to0.89869532
69MP0003448_altered_tumor_morphology0.89528335
70MP0000490_abnormal_crypts_of0.87906127
71MP0009763_increased_sensitivity_to0.87549925
72MP0002166_altered_tumor_susceptibility0.86959944
73MP0001663_abnormal_digestive_system0.86431336
74MP0000604_amyloidosis0.85944091
75MP0009840_abnormal_foam_cell0.85648460
76MP0005390_skeleton_phenotype0.83479058
77MP0002933_joint_inflammation0.74986201
78MP0003045_fibrosis0.73199776
79MP0008874_decreased_physiological_sensi0.70418436
80MP0005075_abnormal_melanosome_morpholog0.68508332
81MP0003656_abnormal_erythrocyte_physiolo0.67814323
82MP0004808_abnormal_hematopoietic_stem0.67537967
83MP0009765_abnormal_xenobiotic_induced0.65618655
84MP0003795_abnormal_bone_structure0.63005569
85MP0000249_abnormal_blood_vessel0.62374254
86MP0002332_abnormal_exercise_endurance0.59656181
87MP0003453_abnormal_keratinocyte_physiol0.59052742
88MP0005167_abnormal_blood-brain_barrier0.58927127
89MP0005319_abnormal_enzyme/_coenzyme0.57413337
90MP0002254_reproductive_system_inflammat0.56757104
91MP0003091_abnormal_cell_migration0.55379631
92MP0002006_tumorigenesis0.55175327
93MP0000015_abnormal_ear_pigmentation0.54594555
94MP0002693_abnormal_pancreas_physiology0.49537511
95MP0003221_abnormal_cardiomyocyte_apopto0.49105294
96MP0005381_digestive/alimentary_phenotyp0.48838566
97MP0002928_abnormal_bile_duct0.48370088
98MP0002019_abnormal_tumor_incidence0.47508762
99MP0001986_abnormal_taste_sensitivity0.47469244
100MP0000609_abnormal_liver_physiology0.46309553

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.10908593
2Recurrent bacterial skin infections (HP:0005406)6.19571826
3Recurrent abscess formation (HP:0002722)6.17200813
4Abnormality of macrophages (HP:0004311)5.83624829
5Recurrent gram-negative bacterial infections (HP:0005420)5.45583530
6Myositis (HP:0100614)5.31505885
7Orchitis (HP:0100796)5.13296715
8Optic neuritis (HP:0100653)4.90385008
9Retrobulbar optic neuritis (HP:0100654)4.90385008
10Mediastinal lymphadenopathy (HP:0100721)4.81375012
11Meningitis (HP:0001287)4.56981600
12Stomatitis (HP:0010280)4.55852617
13Obstructive lung disease (HP:0006536)4.45709983
14Chronic obstructive pulmonary disease (HP:0006510)4.45709983
15Recurrent fungal infections (HP:0002841)4.19696014
16Elevated erythrocyte sedimentation rate (HP:0003565)4.16838970
17Cellulitis (HP:0100658)4.03573193
18Recurrent skin infections (HP:0001581)3.93004521
19Vasculitis (HP:0002633)3.84814997
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.84135295
21Gastrointestinal infarctions (HP:0005244)3.83123416
22Urticaria (HP:0001025)3.67355510
23Encephalitis (HP:0002383)3.63098807
24Increased IgE level (HP:0003212)3.60770498
25Gingivitis (HP:0000230)3.51960131
26Keratoconjunctivitis sicca (HP:0001097)3.51477619
27Hypochromic microcytic anemia (HP:0004840)3.44463721
28Agammaglobulinemia (HP:0004432)3.33651075
29Spontaneous hematomas (HP:0007420)3.32800247
30Recurrent cutaneous fungal infections (HP:0011370)3.32450625
31Chronic mucocutaneous candidiasis (HP:0002728)3.32450625
32Keratoconjunctivitis (HP:0001096)3.23760584
33Gastrointestinal stroma tumor (HP:0100723)3.19614375
34Pulmonary infiltrates (HP:0002113)3.11887188
35Osteomyelitis (HP:0002754)3.08312592
36Hypochromic anemia (HP:0001931)3.08303049
37Recurrent viral infections (HP:0004429)3.06975378
38Inflammation of the large intestine (HP:0002037)2.96450931
39Hemoptysis (HP:0002105)2.94788253
40Chest pain (HP:0100749)2.90568275
41Increased IgM level (HP:0003496)2.88872337
42Lymphopenia (HP:0001888)2.88083726
43Gastrointestinal inflammation (HP:0004386)2.86865568
44Prolonged bleeding time (HP:0003010)2.85478706
45Recurrent pneumonia (HP:0006532)2.84587866
46Episodic fever (HP:0001954)2.76548872
47Recurrent bronchitis (HP:0002837)2.74369803
48Sepsis (HP:0100806)2.73519538
49Petechiae (HP:0000967)2.72665148
50Panhypogammaglobulinemia (HP:0003139)2.69550692
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.67025629
52Colitis (HP:0002583)2.65885161
53Recurrent sinusitis (HP:0011108)2.63203739
54T lymphocytopenia (HP:0005403)2.59444043
55Anorexia (HP:0002039)2.58787689
56Abnormality of liposaccharide metabolism (HP:0010968)2.58179348
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.58179348
58Abnormality of glycolipid metabolism (HP:0010969)2.58179348
59Leukocytosis (HP:0001974)2.53378872
60Abnormality of T cell number (HP:0011839)2.53117323
61Pulmonary embolism (HP:0002204)2.50987109
62Arterial thrombosis (HP:0004420)2.48540474
63Recurrent lower respiratory tract infections (HP:0002783)2.48406691
64Gingival bleeding (HP:0000225)2.45525873
65Abnormality of T cells (HP:0002843)2.43857186
66Abnormality of the pleura (HP:0002103)2.42123491
67Epistaxis (HP:0000421)2.41159112
68Pustule (HP:0200039)2.38196141
69Hypergammaglobulinemia (HP:0010702)2.37686300
70Purpura (HP:0000979)2.36690139
71Gangrene (HP:0100758)2.35828332
72Increased cerebral lipofuscin (HP:0011813)2.35611076
73IgM deficiency (HP:0002850)2.34775916
74Amyloidosis (HP:0011034)2.34544683
75Restrictive lung disease (HP:0002091)2.33383895
76Granulocytopenia (HP:0001913)2.32923634
77Loss of speech (HP:0002371)2.25734250
78Hepatosplenomegaly (HP:0001433)2.25210555
79Abnormality of T cell physiology (HP:0011840)2.24652801
80Premature loss of primary teeth (HP:0006323)2.23946465
81Microcytic anemia (HP:0001935)2.22941380
82Skin ulcer (HP:0200042)2.19821565
83Abnormality of the peritoneum (HP:0002585)2.19774127
84Increased serum ferritin (HP:0003281)2.19706004
85Systemic lupus erythematosus (HP:0002725)2.17376498
86Verrucae (HP:0200043)2.16607492
87Papilloma (HP:0012740)2.16607492
88Peritonitis (HP:0002586)2.14448008
89Chronic otitis media (HP:0000389)2.09598403
90Skin rash (HP:0000988)2.08418155
91Emphysema (HP:0002097)2.07346329
92Dysostosis multiplex (HP:0000943)2.06734809
93Glomerulopathy (HP:0100820)2.04152937
94Abnormality of the endocardium (HP:0004306)2.02809405
95Abnormality of the pericardium (HP:0001697)2.02161441
96Abnormality of iron homeostasis (HP:0011031)2.02108339
97Autoimmune thrombocytopenia (HP:0001973)1.99928291
98Arthralgia (HP:0002829)1.98400730
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96787969
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.94836635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.92249519
2MAP4K13.98392866
3IRAK43.87646942
4BLK3.44058501
5ERN13.10964676
6TYK22.90212854
7MAP2K32.65674807
8CSK2.57474895
9PRPF4B2.31250756
10TNK22.28511001
11FES2.14549147
12GRK62.08956572
13TAOK12.00327653
14MAP3K141.97024167
15MAP3K111.92568006
16SYK1.88202861
17BTK1.84732472
18FGR1.82640955
19TBK11.81552468
20IKBKE1.81367250
21JAK31.80884097
22ZAP701.78678117
23MAP3K31.74066721
24EPHB11.63096476
25HCK1.61711783
26SIK31.55405760
27LYN1.55366806
28TXK1.54282913
29MAP3K131.43765964
30CSF1R1.40036155
31TAOK21.38589843
32JAK11.30746537
33KIT1.29641344
34JAK21.27634200
35TESK21.25530847
36IKBKB1.24906811
37MATK1.21716331
38MAP3K11.19893735
39LCK1.17087068
40SIK21.15909442
41BMPR21.10520555
42MARK31.06911729
43KSR21.03219583
44IRAK30.96147127
45PRKD20.95136944
46YES10.92092396
47MARK20.86362721
48ITK0.85196243
49STK100.84800194
50TAOK30.84785472
51TRIB30.83282204
52SMG10.82942065
53CDK190.80907554
54PDK10.80586500
55IRAK10.79803556
56CDC42BPA0.79504241
57IRAK20.76407937
58TEC0.69939367
59PDPK10.69604240
60FYN0.68710238
61GRK70.68144736
62TGFBR20.67952734
63PTK60.65696179
64SIK10.64004135
65MAPK120.63352624
66PRKCQ0.59071422
67FGFR40.58970723
68MAP3K50.58057144
69LRRK20.51595520
70PIM10.51484928
71MAPK70.50420372
72HIPK20.48545454
73RPS6KC10.44956191
74RPS6KL10.44956191
75DYRK1B0.42965615
76STK110.40315268
77MAPKAPK20.39701990
78MAP3K60.38401060
79CHUK0.37573679
80PTK2B0.37489570
81EPHA30.37291122
82MAP3K80.37164165
83FGFR30.36840600
84RPS6KA60.36133259
85MAP3K70.36021556
86MAP2K60.34983339
87PRKCD0.34230129
88MOS0.34052688
89PRKCZ0.31552165
90DAPK20.31159118
91RAF10.30948056
92ALK0.30907989
93MAP2K40.30858727
94MAPK40.30774642
95PRKCH0.29987448
96MAPK110.28891434
97PRKG20.27440641
98ABL10.27064048
99SGK30.25602198
100CAMKK10.24647142

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.20029378
2Allograft rejection_Homo sapiens_hsa053303.14490378
3Staphylococcus aureus infection_Homo sapiens_hsa051503.05102169
4Graft-versus-host disease_Homo sapiens_hsa053322.99226269
5Osteoclast differentiation_Homo sapiens_hsa043802.96959092
6Autoimmune thyroid disease_Homo sapiens_hsa053202.85554788
7B cell receptor signaling pathway_Homo sapiens_hsa046622.53504468
8Primary immunodeficiency_Homo sapiens_hsa053402.52638552
9Type I diabetes mellitus_Homo sapiens_hsa049402.34218980
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.30964432
11Asthma_Homo sapiens_hsa053102.27754877
12Tuberculosis_Homo sapiens_hsa051522.22851060
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22204180
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19503710
15Antigen processing and presentation_Homo sapiens_hsa046122.01462410
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99649482
17Malaria_Homo sapiens_hsa051441.91795549
18Viral myocarditis_Homo sapiens_hsa054161.90566004
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89879032
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.88982047
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72469917
22Hematopoietic cell lineage_Homo sapiens_hsa046401.72226293
23Measles_Homo sapiens_hsa051621.69815280
24Toxoplasmosis_Homo sapiens_hsa051451.65122780
25Influenza A_Homo sapiens_hsa051641.64940349
26Herpes simplex infection_Homo sapiens_hsa051681.58856605
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55987903
28Chemokine signaling pathway_Homo sapiens_hsa040621.55402000
29Rheumatoid arthritis_Homo sapiens_hsa053231.55401646
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51585181
31Phagosome_Homo sapiens_hsa041451.48995364
32African trypanosomiasis_Homo sapiens_hsa051431.45194136
33Legionellosis_Homo sapiens_hsa051341.44099546
34Acute myeloid leukemia_Homo sapiens_hsa052211.43889722
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39943239
36Other glycan degradation_Homo sapiens_hsa005111.39036220
37T cell receptor signaling pathway_Homo sapiens_hsa046601.37700801
38TNF signaling pathway_Homo sapiens_hsa046681.36821402
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25753879
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.20600553
41Pertussis_Homo sapiens_hsa051331.17810208
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10134989
43Hepatitis C_Homo sapiens_hsa051601.08690560
44Hepatitis B_Homo sapiens_hsa051611.07844060
45Salmonella infection_Homo sapiens_hsa051321.07756203
46Shigellosis_Homo sapiens_hsa051311.02466243
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.02146324
48Lysosome_Homo sapiens_hsa041420.99262687
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96385823
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96260640
51Apoptosis_Homo sapiens_hsa042100.90039763
52Epstein-Barr virus infection_Homo sapiens_hsa051690.88078235
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85256465
54Non-small cell lung cancer_Homo sapiens_hsa052230.81001791
55Platelet activation_Homo sapiens_hsa046110.80574771
56Pancreatic cancer_Homo sapiens_hsa052120.73427556
57VEGF signaling pathway_Homo sapiens_hsa043700.72749426
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70983091
59Chronic myeloid leukemia_Homo sapiens_hsa052200.68709534
60Viral carcinogenesis_Homo sapiens_hsa052030.65744342
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.63474263
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.63375586
63Prolactin signaling pathway_Homo sapiens_hsa049170.63365143
64Endocytosis_Homo sapiens_hsa041440.62906106
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.62386814
66HTLV-I infection_Homo sapiens_hsa051660.62294578
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.61817595
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59806234
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58291835
70Systemic lupus erythematosus_Homo sapiens_hsa053220.55862677
71Renal cell carcinoma_Homo sapiens_hsa052110.54261952
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52586897
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.48132464
74Amoebiasis_Homo sapiens_hsa051460.47614370
75Notch signaling pathway_Homo sapiens_hsa043300.46687323
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44429037
77FoxO signaling pathway_Homo sapiens_hsa040680.43469809
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42806967
79HIF-1 signaling pathway_Homo sapiens_hsa040660.39037445
80GnRH signaling pathway_Homo sapiens_hsa049120.37146335
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36702517
82Type II diabetes mellitus_Homo sapiens_hsa049300.35299087
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35254916
84MAPK signaling pathway_Homo sapiens_hsa040100.34634309
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33872028
86Choline metabolism in cancer_Homo sapiens_hsa052310.33114881
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31646026
88Collecting duct acid secretion_Homo sapiens_hsa049660.31414553
89Endometrial cancer_Homo sapiens_hsa052130.30658123
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29913897
91Insulin resistance_Homo sapiens_hsa049310.29004531
92Bladder cancer_Homo sapiens_hsa052190.28112988
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.27200964
94Colorectal cancer_Homo sapiens_hsa052100.25932201
95Rap1 signaling pathway_Homo sapiens_hsa040150.25606017
96Dorso-ventral axis formation_Homo sapiens_hsa043200.23825191
97mTOR signaling pathway_Homo sapiens_hsa041500.23238212
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22443030
99Inositol phosphate metabolism_Homo sapiens_hsa005620.20704528
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20016956

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