NCF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.74103976
2leukocyte aggregation (GO:0070486)5.66969657
3response to peptidoglycan (GO:0032494)5.66460047
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.24285960
5respiratory burst (GO:0045730)5.13610708
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.93898636
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.93898636
8modulation by symbiont of host immune response (GO:0052553)4.93898636
9positive regulation by symbiont of host defense response (GO:0052509)4.93898636
10modulation by symbiont of host defense response (GO:0052031)4.93898636
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.93898636
12regulation of B cell receptor signaling pathway (GO:0050855)4.88870072
13positive regulation of gamma-delta T cell activation (GO:0046645)4.72149510
14immunoglobulin mediated immune response (GO:0016064)4.64136450
15antigen processing and presentation of endogenous antigen (GO:0019883)4.57284958
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34583393
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34583393
18neutrophil mediated immunity (GO:0002446)4.27291024
19detection of external biotic stimulus (GO:0098581)4.27242427
20neutrophil activation (GO:0042119)4.23170513
21granulocyte activation (GO:0036230)4.07398617
22cellular extravasation (GO:0045123)3.95526001
23detection of molecule of bacterial origin (GO:0032490)3.93572167
24macrophage activation involved in immune response (GO:0002281)3.92502091
25regulation of B cell differentiation (GO:0045577)3.84778601
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.84393523
27positive regulation of antigen processing and presentation (GO:0002579)3.83130685
28regulation of interferon-beta biosynthetic process (GO:0045357)3.82874318
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.82546750
30positive regulation of B cell differentiation (GO:0045579)3.76745209
31cellular response to zinc ion (GO:0071294)3.74549547
32detection of biotic stimulus (GO:0009595)3.74031184
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69250052
34response to fungus (GO:0009620)3.64810644
35B cell receptor signaling pathway (GO:0050853)3.63689258
36negative regulation of leukocyte mediated immunity (GO:0002704)3.63069861
37B cell mediated immunity (GO:0019724)3.62840763
38myeloid cell activation involved in immune response (GO:0002275)3.61657511
39response to host immune response (GO:0052572)3.61086491
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61086491
41positive regulation of mast cell activation (GO:0033005)3.60132844
42response to interleukin-15 (GO:0070672)3.59750008
43microglial cell activation (GO:0001774)3.58798694
44reactive oxygen species biosynthetic process (GO:1903409)3.57161480
45negative regulation of erythrocyte differentiation (GO:0045647)3.55712839
46hydrogen peroxide biosynthetic process (GO:0050665)3.54825265
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52028718
48negative regulation of cell killing (GO:0031342)3.50348103
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.50348103
50response to muramyl dipeptide (GO:0032495)3.47048076
51macrophage activation (GO:0042116)3.46084881
52leukocyte mediated cytotoxicity (GO:0001909)3.45417077
53defense response to protozoan (GO:0042832)3.45294301
54positive regulation of interferon-alpha production (GO:0032727)3.44977164
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.44087764
56negative regulation of interleukin-12 production (GO:0032695)3.43474137
57regulation of mast cell degranulation (GO:0043304)3.39269450
58regulation of mast cell activation (GO:0033003)3.38845031
59production of molecular mediator involved in inflammatory response (GO:0002532)3.38072570
60negative regulation of phagocytosis (GO:0050765)3.37672955
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.36271714
62leukocyte migration involved in inflammatory response (GO:0002523)3.33705463
63superoxide anion generation (GO:0042554)3.32283072
64regulation of interferon-alpha production (GO:0032647)3.31440161
65myeloid leukocyte mediated immunity (GO:0002444)3.28950541
66response to host (GO:0075136)3.28551162
67response to host defenses (GO:0052200)3.28551162
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28551162
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27704439
70cellular response to interleukin-15 (GO:0071350)3.26813829
71positive regulation of mast cell degranulation (GO:0043306)3.26643280
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.26643280
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26473816
74regulation of antigen processing and presentation (GO:0002577)3.26473243
75interferon-gamma-mediated signaling pathway (GO:0060333)3.24599211
76negative regulation of T cell mediated immunity (GO:0002710)3.23409944
77germinal center formation (GO:0002467)3.23026179
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19474335
79modulation of growth of symbiont involved in interaction with host (GO:0044144)3.19312671
80regulation of growth of symbiont in host (GO:0044126)3.19312671
81negative regulation of growth of symbiont in host (GO:0044130)3.19312671
82negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.19312671
83response to protozoan (GO:0001562)3.18541061
84NIK/NF-kappaB signaling (GO:0038061)3.17968197
85leukocyte cell-cell adhesion (GO:0007159)3.16962627
86lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16433404
87regulation of T cell tolerance induction (GO:0002664)3.15136800
88mast cell activation (GO:0045576)3.14634910
89regulation of mast cell activation involved in immune response (GO:0033006)3.14298735
90neutrophil chemotaxis (GO:0030593)3.13950315
91defense response to fungus (GO:0050832)3.12724683
92disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.12597191
93killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.12597191
94regulation of gamma-delta T cell activation (GO:0046643)3.11751646
95detection of other organism (GO:0098543)3.10281946
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10250187
97regulation of tolerance induction (GO:0002643)3.09939923
98negative regulation of myeloid cell apoptotic process (GO:0033033)3.09575050
99negative regulation of cytokine production involved in immune response (GO:0002719)3.08611879
100T cell migration (GO:0072678)3.08281104
101regulation of regulated secretory pathway (GO:1903305)3.07993113
102regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07300414
103neutrophil migration (GO:1990266)3.04937473
104positive thymic T cell selection (GO:0045059)3.04634837
105natural killer cell mediated cytotoxicity (GO:0042267)3.01081937
106natural killer cell mediated immunity (GO:0002228)3.01081937
107type I interferon signaling pathway (GO:0060337)2.99689769
108cellular response to type I interferon (GO:0071357)2.99689769
109antigen processing and presentation via MHC class Ib (GO:0002475)2.99680281
110response to type I interferon (GO:0034340)2.98694743
111negative regulation of interleukin-6 production (GO:0032715)2.98114577
112regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97796429
113regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96846615
114myeloid dendritic cell activation (GO:0001773)2.96335145
115leukocyte degranulation (GO:0043299)2.96057712
116actin nucleation (GO:0045010)2.95670177
117regulation of gamma-delta T cell differentiation (GO:0045586)2.95296515
118negative regulation of innate immune response (GO:0045824)2.92664261
119regulation of leukocyte degranulation (GO:0043300)2.90141216
120detection of bacterium (GO:0016045)2.88696404
121regulation of T-helper 2 cell differentiation (GO:0045628)2.88457021
122positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84908728
123myeloid leukocyte activation (GO:0002274)2.84430368
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.82944951
125negative thymic T cell selection (GO:0045060)2.82872433
126regulation of T cell mediated cytotoxicity (GO:0001914)2.80046917
127myeloid dendritic cell differentiation (GO:0043011)2.80046280
128regulation of alpha-beta T cell proliferation (GO:0046640)2.80029834
129positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79610363
130regulation of chemokine biosynthetic process (GO:0045073)2.78911943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.73665126
2* IRF8_22096565_ChIP-ChIP_GC-B_Human5.17781069
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.76314786
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.88709088
5E2F7_22180533_ChIP-Seq_HELA_Human3.83437589
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72722138
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.68767508
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52341078
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44960822
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.37341045
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26527262
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.25363381
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12749694
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96086609
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.94116084
16* SPI1_23547873_ChIP-Seq_NB4_Human2.69679110
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.63531890
18VDR_21846776_ChIP-Seq_THP-1_Human2.61888784
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56810537
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52801769
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50921108
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.48726345
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39033151
24SCL_19346495_ChIP-Seq_HPC-7_Human2.35579116
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27950135
26MYB_26560356_Chip-Seq_TH2_Human2.22529963
27* VDR_24763502_ChIP-Seq_THP-1_Human2.21144259
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.16967747
29MYC_22102868_ChIP-Seq_BL_Human2.14918229
30MAF_26560356_Chip-Seq_TH1_Human2.14696021
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04360361
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03573899
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02777891
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97687396
35MYB_26560356_Chip-Seq_TH1_Human1.89272350
36* SPI1_23127762_ChIP-Seq_K562_Human1.84886295
37UTX_26944678_Chip-Seq_JUKART_Human1.84284435
38RUNX_20019798_ChIP-Seq_JUKART_Human1.84200688
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81465054
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74497793
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73270209
42PU_27001747_Chip-Seq_BMDM_Mouse1.63258505
43* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62413634
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57177134
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56361449
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.56163039
47* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55515562
48* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52907076
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47842301
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46650581
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45407907
52TCF7_22412390_ChIP-Seq_EML_Mouse1.43165511
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39598871
54MAF_26560356_Chip-Seq_TH2_Human1.34855435
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33540275
56* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32043540
57* GATA3_27048872_Chip-Seq_THYMUS_Human1.31585298
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30118879
59* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29720026
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29139483
61* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26517641
62* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25177566
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21148280
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20549560
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20104331
66BCOR_27268052_Chip-Seq_Bcells_Human1.18850690
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18769024
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18226922
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17789799
70GATA3_26560356_Chip-Seq_TH2_Human1.16314884
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15687079
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15029807
73VDR_24787735_ChIP-Seq_THP-1_Human1.13400190
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12085984
75* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12072287
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11520530
77* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09935519
78* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08809562
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08465453
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06519621
81* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04350560
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.04163975
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03964551
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.03414810
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.02639031
86* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00863284
87* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00108389
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99974718
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99809816
90NCOR1_26117541_ChIP-Seq_K562_Human0.99613695
91* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98571364
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98545141
93GATA1_22025678_ChIP-Seq_K562_Human0.97637121
94TFEB_21752829_ChIP-Seq_HELA_Human0.97211672
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.95268515
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.92922198
97* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92158753
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91031225
99KDM2B_26808549_Chip-Seq_DND41_Human0.90659083
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89393672
101CIITA_25753668_ChIP-Seq_RAJI_Human0.86614465
102* SPI1_20517297_ChIP-Seq_HL60_Human0.84190189
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83522751
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80055327
105BCL6_27268052_Chip-Seq_Bcells_Human0.78567574
106VDR_23849224_ChIP-Seq_CD4+_Human0.71302230
107* LXR_22292898_ChIP-Seq_THP-1_Human0.71035544
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70080479
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.69804989
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.69734311
111GATA2_19941826_ChIP-Seq_K562_Human0.69441421
112GATA1_19941826_ChIP-Seq_K562_Human0.68433593
113P300_27268052_Chip-Seq_Bcells_Human0.67963701
114* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66648933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.58932696
2MP0003436_decreased_susceptibility_to3.87591115
3MP0003303_peritoneal_inflammation3.76840903
4MP0009785_altered_susceptibility_to3.73379844
5* MP0002419_abnormal_innate_immunity3.24861953
6MP0005000_abnormal_immune_tolerance3.18748578
7MP0000685_abnormal_immune_system3.07810635
8MP0002148_abnormal_hypersensitivity_rea3.06202874
9MP0005387_immune_system_phenotype3.00935009
10MP0001790_abnormal_immune_system3.00935009
11* MP0005025_abnormal_response_to3.00679075
12MP0005671_abnormal_response_to3.00020637
13MP0001800_abnormal_humoral_immune2.98870411
14MP0002452_abnormal_antigen_presenting2.88833255
15MP0002723_abnormal_immune_serum2.67740558
16* MP0002420_abnormal_adaptive_immunity2.61787373
17* MP0001819_abnormal_immune_cell2.60686373
18MP0006082_CNS_inflammation2.42280155
19MP0005058_abnormal_lysosome_morphology2.36150190
20MP0005464_abnormal_platelet_physiology2.31818801
21MP0002405_respiratory_system_inflammati2.30780942
22MP0003724_increased_susceptibility_to2.25101514
23MP0001853_heart_inflammation2.09871167
24MP0002398_abnormal_bone_marrow2.09364896
25MP0003172_abnormal_lysosome_physiology2.04409710
26MP0000716_abnormal_immune_system2.03928798
27MP0001845_abnormal_inflammatory_respons1.99670397
28MP0001533_abnormal_skeleton_physiology1.98048278
29MP0004510_myositis1.95240129
30MP0009278_abnormal_bone_marrow1.93782846
31MP0009333_abnormal_splenocyte_physiolog1.84342264
32MP0000689_abnormal_spleen_morphology1.82866693
33MP0010155_abnormal_intestine_physiology1.81509014
34MP0003183_abnormal_peptide_metabolism1.80622467
35MP0003763_abnormal_thymus_physiology1.78259530
36MP0004947_skin_inflammation1.76972524
37MP0002396_abnormal_hematopoietic_system1.72644039
38MP0002429_abnormal_blood_cell1.70821498
39MP0002722_abnormal_immune_system1.69811592
40MP0002132_abnormal_respiratory_system1.65633656
41MP0005397_hematopoietic_system_phenotyp1.62909814
42MP0001545_abnormal_hematopoietic_system1.62909814
43MP0003300_gastrointestinal_ulcer1.62727999
44MP0002166_altered_tumor_susceptibility1.61869951
45MP0000343_altered_response_to1.58260034
46MP0000858_altered_metastatic_potential1.57046729
47MP0002006_tumorigenesis1.56799978
48MP0003448_altered_tumor_morphology1.55418416
49MP0008469_abnormal_protein_level1.55345390
50MP0005310_abnormal_salivary_gland1.53313564
51MP0005174_abnormal_tail_pigmentation1.45860379
52MP0009764_decreased_sensitivity_to1.43445319
53MP0003806_abnormal_nucleotide_metabolis1.42473030
54MP0001873_stomach_inflammation1.38897018
55MP0000465_gastrointestinal_hemorrhage1.35131766
56MP0003191_abnormal_cellular_cholesterol1.33366597
57MP0004808_abnormal_hematopoietic_stem1.31574901
58MP0005451_abnormal_body_composition1.28869689
59MP0002933_joint_inflammation1.28734748
60MP0000569_abnormal_digit_pigmentation1.28509552
61MP0003075_altered_response_to1.21351730
62MP0010307_abnormal_tumor_latency1.15684189
63MP0000703_abnormal_thymus_morphology1.14074693
64MP0000490_abnormal_crypts_of1.12880699
65MP0001851_eye_inflammation1.05427544
66MP0002998_abnormal_bone_remodeling1.03415303
67MP0003866_abnormal_defecation1.00174384
68MP0009840_abnormal_foam_cell0.98779720
69MP0005166_decreased_susceptibility_to0.97138404
70MP0000015_abnormal_ear_pigmentation0.95679016
71MP0003656_abnormal_erythrocyte_physiolo0.95597516
72MP0000604_amyloidosis0.94840232
73MP0008004_abnormal_stomach_pH0.91872083
74MP0005076_abnormal_cell_differentiation0.91598460
75MP0009763_increased_sensitivity_to0.90439841
76MP0004381_abnormal_hair_follicle0.89784084
77MP0003828_pulmonary_edema0.87787424
78MP0002019_abnormal_tumor_incidence0.86891789
79MP0005167_abnormal_blood-brain_barrier0.86640013
80MP0005390_skeleton_phenotype0.84028339
81MP0003566_abnormal_cell_adhesion0.79330899
82MP0003186_abnormal_redox_activity0.74085292
83MP0002277_abnormal_respiratory_mucosa0.73608704
84MP0001663_abnormal_digestive_system0.71016941
85MP0008260_abnormal_autophagy0.70771812
86MP0000249_abnormal_blood_vessel0.68655819
87MP0005164_abnormal_response_to0.68439854
88MP0003693_abnormal_embryo_hatching0.67521998
89MP0003045_fibrosis0.67150687
90MP0005023_abnormal_wound_healing0.67073023
91MP0000371_diluted_coat_color0.65775603
92MP0001986_abnormal_taste_sensitivity0.65703578
93MP0003795_abnormal_bone_structure0.62921216
94MP0008057_abnormal_DNA_replication0.62856603
95MP0005319_abnormal_enzyme/_coenzyme0.62713645
96MP0004782_abnormal_surfactant_physiolog0.60379393
97MP0008874_decreased_physiological_sensi0.58586861
98MP0010352_gastrointestinal_tract_polyps0.56771053
99MP0002136_abnormal_kidney_physiology0.56600677
100MP0005075_abnormal_melanosome_morpholog0.55733595
101MP0004883_abnormal_blood_vessel0.55668626
102MP0008873_increased_physiological_sensi0.54931191
103MP0003329_amyloid_beta_deposits0.53749430
104MP0002095_abnormal_skin_pigmentation0.53565957
105MP0000920_abnormal_myelination0.51814226
106MP0003453_abnormal_keratinocyte_physiol0.51057018
107MP0000313_abnormal_cell_death0.50982276
108MP0000609_abnormal_liver_physiology0.50521583
109MP0009765_abnormal_xenobiotic_induced0.50044378
110MP0003077_abnormal_cell_cycle0.48764332
111MP0003690_abnormal_glial_cell0.47471069
112MP0003221_abnormal_cardiomyocyte_apopto0.47224587
113MP0005083_abnormal_biliary_tract0.46899014
114MP0005381_digestive/alimentary_phenotyp0.46126755
115MP0006054_spinal_hemorrhage0.44732283
116MP0002138_abnormal_hepatobiliary_system0.44552807
117MP0002693_abnormal_pancreas_physiology0.42523969
118MP0005584_abnormal_enzyme/coenzyme_acti0.41904977

Predicted human phenotypes

RankGene SetZ-score
1* Recurrent abscess formation (HP:0002722)7.32358331
2Eczematoid dermatitis (HP:0000976)7.19854671
3Recurrent bacterial skin infections (HP:0005406)6.95188184
4Recurrent gram-negative bacterial infections (HP:0005420)5.93070759
5Abnormality of macrophages (HP:0004311)5.02723821
6Recurrent skin infections (HP:0001581)4.54585889
7Elevated erythrocyte sedimentation rate (HP:0003565)4.54290228
8* Mediastinal lymphadenopathy (HP:0100721)4.46315281
9Myositis (HP:0100614)4.45170968
10Recurrent fungal infections (HP:0002841)4.41473119
11* Chronic obstructive pulmonary disease (HP:0006510)4.20217244
12* Obstructive lung disease (HP:0006536)4.20217244
13Cellulitis (HP:0100658)3.99578407
14Vacuolated lymphocytes (HP:0001922)3.78762737
15Recurrent viral infections (HP:0004429)3.72858916
16* Gingivitis (HP:0000230)3.64055113
17IgM deficiency (HP:0002850)3.57153917
18* Meningitis (HP:0001287)3.56565569
19Orchitis (HP:0100796)3.52205180
20Vasculitis (HP:0002633)3.50776687
21Autoimmune thrombocytopenia (HP:0001973)3.48970253
22Chronic mucocutaneous candidiasis (HP:0002728)3.47736487
23Recurrent cutaneous fungal infections (HP:0011370)3.47736487
24Increased cerebral lipofuscin (HP:0011813)3.42848599
25Retrobulbar optic neuritis (HP:0100654)3.36878798
26Optic neuritis (HP:0100653)3.36878798
27Prolonged bleeding time (HP:0003010)3.35315864
28Pustule (HP:0200039)3.35189502
29Chronic otitis media (HP:0000389)3.32735553
30Systemic lupus erythematosus (HP:0002725)3.23362874
31Recurrent bronchitis (HP:0002837)3.17667363
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.16146124
33Hypochromic microcytic anemia (HP:0004840)3.10713596
34Periodontitis (HP:0000704)3.05223695
35Recurrent pneumonia (HP:0006532)3.01849391
36Agammaglobulinemia (HP:0004432)2.97640425
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.94488752
38Osteomyelitis (HP:0002754)2.93094668
39Hypochromic anemia (HP:0001931)2.91545906
40Pulmonary infiltrates (HP:0002113)2.88247976
41Petechiae (HP:0000967)2.88202411
42Inflammation of the large intestine (HP:0002037)2.85910559
43* Urticaria (HP:0001025)2.79823191
44Leukocytosis (HP:0001974)2.79216536
45Interstitial pulmonary disease (HP:0006530)2.77935805
46Episodic fever (HP:0001954)2.75960624
47Gastrointestinal inflammation (HP:0004386)2.74370123
48Thrombocytosis (HP:0001894)2.74234864
49Colitis (HP:0002583)2.71884411
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70709819
51Dysostosis multiplex (HP:0000943)2.69210804
52Recurrent lower respiratory tract infections (HP:0002783)2.67019195
53Abnormality of T cell physiology (HP:0011840)2.64573203
54Purpura (HP:0000979)2.64170027
55Amyloidosis (HP:0011034)2.63970708
56Lymphopenia (HP:0001888)2.63922550
57Loss of speech (HP:0002371)2.63524688
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.62758459
59Pulmonary embolism (HP:0002204)2.57436323
60Abnormality of T cells (HP:0002843)2.56266744
61Spontaneous hematomas (HP:0007420)2.56257017
62Thyroiditis (HP:0100646)2.55167962
63Basal ganglia calcification (HP:0002135)2.52714161
64Increased serum ferritin (HP:0003281)2.51339018
65Gastrointestinal stroma tumor (HP:0100723)2.50435222
66Anorexia (HP:0002039)2.47551007
67* Stomatitis (HP:0010280)2.46890610
68Abnormality of glycolipid metabolism (HP:0010969)2.46085984
69Abnormality of liposaccharide metabolism (HP:0010968)2.46085984
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.46085984
71Agnosia (HP:0010524)2.45167495
72Abnormality of T cell number (HP:0011839)2.43655881
73Disinhibition (HP:0000734)2.43438314
74Hemoptysis (HP:0002105)2.42563870
75Eosinophilia (HP:0001880)2.41756740
76Keratoconjunctivitis sicca (HP:0001097)2.34300947
77Abnormality of iron homeostasis (HP:0011031)2.33898588
78Microcytic anemia (HP:0001935)2.32114794
79T lymphocytopenia (HP:0005403)2.31717082
80Abnormality of the pleura (HP:0002103)2.30637176
81Arterial thrombosis (HP:0004420)2.30109082
82Hypergammaglobulinemia (HP:0010702)2.28698262
83Nasal polyposis (HP:0100582)2.28468945
84Chest pain (HP:0100749)2.28040802
85* Sepsis (HP:0100806)2.26696635
86Panhypogammaglobulinemia (HP:0003139)2.26094982
87Mucopolysacchariduria (HP:0008155)2.24727195
88Urinary glycosaminoglycan excretion (HP:0003541)2.24727195
89Glomerulonephritis (HP:0000099)2.23930337
90* Skin ulcer (HP:0200042)2.23078811
91Abnormality of the prostate (HP:0008775)2.22914189
92Increased IgM level (HP:0003496)2.22523598
93Hepatosplenomegaly (HP:0001433)2.22321666
94Keratoconjunctivitis (HP:0001096)2.21992542
95Granulocytopenia (HP:0001913)2.20815325
96Axonal loss (HP:0003447)2.20403669
97Abnormality of eosinophils (HP:0001879)2.20225257
98Gingival bleeding (HP:0000225)2.20216493
99Gangrene (HP:0100758)2.19228800
100Increased IgE level (HP:0003212)2.17340534
101Encephalitis (HP:0002383)2.16319009
102Gastrointestinal infarctions (HP:0005244)2.15876352
103Combined immunodeficiency (HP:0005387)2.15778224
104Restrictive lung disease (HP:0002091)2.15220777
105Epistaxis (HP:0000421)2.14718844
106Peritonitis (HP:0002586)2.13216305
107Abnormality of the heme biosynthetic pathway (HP:0010472)2.12071617
108IgG deficiency (HP:0004315)2.10452019
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09873446
110Abnormality of polysaccharide metabolism (HP:0011012)2.09873446
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09873446
112Severe combined immunodeficiency (HP:0004430)2.07776027
113Autoimmune hemolytic anemia (HP:0001890)2.07636510
114IgA deficiency (HP:0002720)2.05762450
115Glomerulopathy (HP:0100820)2.05559942
116Abnormality of the peritoneum (HP:0002585)2.05044286
117Hematochezia (HP:0002573)2.02927350
118Chronic diarrhea (HP:0002028)2.02900295
119Polyneuropathy (HP:0001271)2.01668808
120Abnormality of the nasal mucosa (HP:0000433)2.01488703
121Premature loss of primary teeth (HP:0006323)2.00547547
122Vertigo (HP:0002321)1.97416180
123Skin rash (HP:0000988)1.97413053
124Acute hepatic failure (HP:0006554)1.93564090
125Abnormality of transition element cation homeostasis (HP:0011030)1.92723485
126Acne (HP:0001061)1.88668770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.34077137
2BLK4.13095321
3IRAK43.87862006
4RIPK43.34553279
5MAP3K143.03015895
6TYK22.63795300
7TBK12.60741894
8KIT2.47077391
9TXK2.43893485
10IRAK32.42054944
11BTK2.23833684
12IKBKE2.19688897
13PRPF4B2.15274403
14JAK32.11376274
15CSF1R2.07832416
16ERN12.01678924
17ZAP701.99687625
18SYK1.96676648
19FES1.81211227
20CSK1.80377193
21IKBKB1.79400771
22TEC1.77360743
23STK101.70872347
24HCK1.63148196
25MAP2K31.53254467
26JAK11.51584436
27TAOK31.49553232
28GRK61.49104263
29LYN1.45941296
30NME21.41167034
31MAP3K101.40303180
32LCK1.35331564
33MAP3K131.33327739
34CLK11.33323565
35TESK21.30697166
36MAP3K11.23222689
37EPHB11.23100255
38ITK1.21432683
39FGR1.18095523
40PIM11.14797326
41LRRK21.10896870
42PIM21.06672557
43RPS6KA41.05010979
44TRPM71.02381343
45KDR0.98757058
46MAP3K120.96880694
47TGFBR20.94484579
48NEK90.91401174
49KSR20.89852251
50SMG10.89518207
51CHUK0.89383870
52MATK0.88795611
53JAK20.87475253
54MAP3K110.83660726
55MARK20.82569300
56IRAK20.81172188
57STK40.79785411
58MARK30.79689873
59IRAK10.78883325
60TESK10.76733289
61PRKD20.76548314
62SIK20.74395308
63CDK190.70059530
64PBK0.69962423
65MAP3K60.68560320
66EIF2AK30.68311866
67PDPK10.67155197
68FLT30.65998249
69MAPK120.63263923
70ABL10.58017155
71PKN20.57827234
72YES10.57173930
73TRIB30.56994292
74MAP2K60.56022403
75* PRKCD0.55886145
76MST40.54538325
77PAK40.53847922
78TTN0.53719346
79NEK20.52569981
80RPS6KA60.52272603
81EIF2AK20.51284742
82TNK20.50786347
83CDC42BPA0.50106551
84EEF2K0.50069408
85MAPK40.48730281
86MAP3K70.48165240
87CAMKK20.47781499
88PIK3CG0.47760911
89HIPK20.47347503
90MAP3K30.46928566
91DAPK20.46693171
92MAPKAPK20.46647773
93EGFR0.46221311
94PRKCQ0.46071729
95CDK40.46040887
96MAP2K40.45787411
97SCYL20.44416408
98MAP3K80.43336555
99RPS6KL10.42652996
100RPS6KC10.42652996
101FGFR30.40510494
102FGFR40.40441416
103STK110.40322096
104FYN0.40151239
105MAPK70.38939740
106GRK70.38220162
107DYRK1B0.38123778
108RAF10.36587368
109PTK60.35630787
110ABL20.35316644
111PDK10.35218880
112SIK30.35123697
113CAMKK10.31483924
114MAP3K50.31286709
115ALK0.31269739
116EIF2AK10.30140649
117TAOK10.28729053
118MAP2K20.27978402
119ERBB30.27332468
120RET0.27329205
121PTK2B0.26700242
122CDK60.26536623
123PRKG20.26304207
124MAPK110.24707621
125ACVR1B0.24659022
126STK240.24335796
127TAOK20.23596889
128BMPR20.23516289
129SIK10.21313105
130RPS6KA10.20889440

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051403.32525061
2Staphylococcus aureus infection_Homo sapiens_hsa051502.89750687
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.53569798
4B cell receptor signaling pathway_Homo sapiens_hsa046622.50139496
5Primary immunodeficiency_Homo sapiens_hsa053402.48369281
6* Osteoclast differentiation_Homo sapiens_hsa043802.45471391
7Graft-versus-host disease_Homo sapiens_hsa053322.32100495
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30124778
9Legionellosis_Homo sapiens_hsa051342.22147303
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.13205568
11Pertussis_Homo sapiens_hsa051332.10876693
12Tuberculosis_Homo sapiens_hsa051522.10574308
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09957048
14Measles_Homo sapiens_hsa051622.07924842
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07577035
16Allograft rejection_Homo sapiens_hsa053302.00612591
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98738891
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98299732
19Hematopoietic cell lineage_Homo sapiens_hsa046401.97148047
20Other glycan degradation_Homo sapiens_hsa005111.95976190
21Antigen processing and presentation_Homo sapiens_hsa046121.91804942
22Asthma_Homo sapiens_hsa053101.87629353
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87354840
24Malaria_Homo sapiens_hsa051441.82751114
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82121067
26Lysosome_Homo sapiens_hsa041421.77729732
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.67481773
28Salmonella infection_Homo sapiens_hsa051321.56686200
29Shigellosis_Homo sapiens_hsa051311.53888232
30Herpes simplex infection_Homo sapiens_hsa051681.52550314
31Chemokine signaling pathway_Homo sapiens_hsa040621.48305585
32TNF signaling pathway_Homo sapiens_hsa046681.47887212
33Toxoplasmosis_Homo sapiens_hsa051451.46870879
34Influenza A_Homo sapiens_hsa051641.46649526
35Apoptosis_Homo sapiens_hsa042101.45729171
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43787640
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42545984
38Rheumatoid arthritis_Homo sapiens_hsa053231.34901598
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.30280183
40* Phagosome_Homo sapiens_hsa041451.29192466
41* Leukocyte transendothelial migration_Homo sapiens_hsa046701.27710805
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27161212
43T cell receptor signaling pathway_Homo sapiens_hsa046601.24673158
44DNA replication_Homo sapiens_hsa030301.22627243
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18877810
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18160614
47Viral myocarditis_Homo sapiens_hsa054161.15374771
48Hepatitis B_Homo sapiens_hsa051611.15180398
49Type I diabetes mellitus_Homo sapiens_hsa049401.12468295
50African trypanosomiasis_Homo sapiens_hsa051431.07130606
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03980033
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94594714
53Acute myeloid leukemia_Homo sapiens_hsa052210.93937240
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88556163
55Autoimmune thyroid disease_Homo sapiens_hsa053200.86971711
56Platelet activation_Homo sapiens_hsa046110.82531792
57Base excision repair_Homo sapiens_hsa034100.81846419
58Pancreatic cancer_Homo sapiens_hsa052120.80563008
59Epstein-Barr virus infection_Homo sapiens_hsa051690.80315865
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76581840
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75861371
62Hepatitis C_Homo sapiens_hsa051600.75192167
63Chronic myeloid leukemia_Homo sapiens_hsa052200.74970716
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73235359
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.70695382
66Pentose phosphate pathway_Homo sapiens_hsa000300.64211947
67Mismatch repair_Homo sapiens_hsa034300.63996899
68Caffeine metabolism_Homo sapiens_hsa002320.60530875
69Viral carcinogenesis_Homo sapiens_hsa052030.58303952
70Amoebiasis_Homo sapiens_hsa051460.57291313
71VEGF signaling pathway_Homo sapiens_hsa043700.56370911
72Homologous recombination_Homo sapiens_hsa034400.53606555
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52256653
74Collecting duct acid secretion_Homo sapiens_hsa049660.51437553
75p53 signaling pathway_Homo sapiens_hsa041150.50222910
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.48855136
77Renal cell carcinoma_Homo sapiens_hsa052110.48472719
78HTLV-I infection_Homo sapiens_hsa051660.48315022
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.47632240
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44022150
81Regulation of autophagy_Homo sapiens_hsa041400.42988596
82Non-homologous end-joining_Homo sapiens_hsa034500.40493125
83Non-small cell lung cancer_Homo sapiens_hsa052230.39898314
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38808948
85HIF-1 signaling pathway_Homo sapiens_hsa040660.38078722
86Small cell lung cancer_Homo sapiens_hsa052220.37796561
87Prolactin signaling pathway_Homo sapiens_hsa049170.37771157
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37413334
89Endocytosis_Homo sapiens_hsa041440.37121929
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37083943
91FoxO signaling pathway_Homo sapiens_hsa040680.36425227
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.36280267
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35677729
94GnRH signaling pathway_Homo sapiens_hsa049120.34292867
95Renin-angiotensin system_Homo sapiens_hsa046140.33815268
96Complement and coagulation cascades_Homo sapiens_hsa046100.33403621
97Choline metabolism in cancer_Homo sapiens_hsa052310.32475205
98Systemic lupus erythematosus_Homo sapiens_hsa053220.32316580
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32015857
100Ribosome_Homo sapiens_hsa030100.31720221
101Proteasome_Homo sapiens_hsa030500.31345023
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31308123
103mTOR signaling pathway_Homo sapiens_hsa041500.31182694
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30578100
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28491946
106MAPK signaling pathway_Homo sapiens_hsa040100.28107878
107Bladder cancer_Homo sapiens_hsa052190.27339412
108Endometrial cancer_Homo sapiens_hsa052130.26993810
109Type II diabetes mellitus_Homo sapiens_hsa049300.26214242
110Dorso-ventral axis formation_Homo sapiens_hsa043200.23576094
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22945314
112Colorectal cancer_Homo sapiens_hsa052100.22222182
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.21743581
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20470292
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20322960
116Nucleotide excision repair_Homo sapiens_hsa034200.19219210
117Notch signaling pathway_Homo sapiens_hsa043300.18437789
118Insulin resistance_Homo sapiens_hsa049310.17693922
119Sphingolipid metabolism_Homo sapiens_hsa006000.15789402

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »