NCK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88382949
2neutrophil activation involved in immune response (GO:0002283)4.47069083
3regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.24468584
4response to peptidoglycan (GO:0032494)4.23716921
5proteasome assembly (GO:0043248)4.17559680
6positive regulation of interferon-alpha production (GO:0032727)4.13579134
7T-helper 1 type immune response (GO:0042088)4.01118497
8production of molecular mediator involved in inflammatory response (GO:0002532)3.92299257
9piRNA metabolic process (GO:0034587)3.91766866
10positive regulation of gamma-delta T cell activation (GO:0046645)3.91574917
11response to type I interferon (GO:0034340)3.91451056
12cellular response to type I interferon (GO:0071357)3.90268942
13type I interferon signaling pathway (GO:0060337)3.90268942
14negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.89444472
15regulation of interferon-alpha production (GO:0032647)3.86771129
16response to interferon-beta (GO:0035456)3.86667246
17regulation of T-helper 1 cell differentiation (GO:0045625)3.80425618
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76133864
19mannosylation (GO:0097502)3.73994872
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73889752
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73889752
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.72126614
23positive regulation of natural killer cell differentiation (GO:0032825)3.71697692
24regulation of interleukin-12 biosynthetic process (GO:0045075)3.71647826
25detection of molecule of bacterial origin (GO:0032490)3.67448231
26cellular response to interferon-beta (GO:0035458)3.66863060
27platelet dense granule organization (GO:0060155)3.64136051
28positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.61980547
29antigen processing and presentation of endogenous antigen (GO:0019883)3.61466907
30response to interferon-alpha (GO:0035455)3.54961360
31negative regulation of interleukin-17 production (GO:0032700)3.53893348
32detection of other organism (GO:0098543)3.51051634
33nucleotide transmembrane transport (GO:1901679)3.48585084
34positive regulation of interleukin-12 production (GO:0032735)3.48026617
35neural tube formation (GO:0001841)3.45917300
36DNA deamination (GO:0045006)3.43538782
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42582036
38positive regulation of interferon-beta production (GO:0032728)3.39143345
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.36563494
40modulation by symbiont of host immune response (GO:0052553)3.36563494
41positive regulation by symbiont of host defense response (GO:0052509)3.36563494
42modulation by symbiont of host defense response (GO:0052031)3.36563494
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36563494
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36563494
45immunoglobulin mediated immune response (GO:0016064)3.34363096
46negative regulation of viral genome replication (GO:0045071)3.29482143
47neutrophil activation (GO:0042119)3.27325323
48regulation of meiosis I (GO:0060631)3.26688513
49myeloid dendritic cell activation (GO:0001773)3.25878966
50positive regulation of alpha-beta T cell proliferation (GO:0046641)3.25835601
51myeloid dendritic cell differentiation (GO:0043011)3.24187962
52regulation of alpha-beta T cell proliferation (GO:0046640)3.23275458
53granulocyte activation (GO:0036230)3.22545781
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.22211999
55regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.20178686
56regulation of interferon-beta biosynthetic process (GO:0045357)3.19393872
57regulation of activation of Janus kinase activity (GO:0010533)3.19277666
58superoxide anion generation (GO:0042554)3.18486378
59positive regulation of NF-kappaB import into nucleus (GO:0042346)3.18238892
60hydrogen peroxide biosynthetic process (GO:0050665)3.17578284
61interferon-gamma-mediated signaling pathway (GO:0060333)3.14165030
62cellular response to zinc ion (GO:0071294)3.14083852
63regulation of RIG-I signaling pathway (GO:0039535)3.12397943
64detection of external biotic stimulus (GO:0098581)3.11925293
65NIK/NF-kappaB signaling (GO:0038061)3.07401285
66regulation of fever generation (GO:0031620)3.07096258
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04476490
68GPI anchor metabolic process (GO:0006505)3.03810278
69regulation of natural killer cell differentiation (GO:0032823)3.03044354
70GPI anchor biosynthetic process (GO:0006506)2.98986559
71Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98720769
72preassembly of GPI anchor in ER membrane (GO:0016254)2.97819199
73positive regulation of heat generation (GO:0031652)2.97167157
74regulation of chemokine biosynthetic process (GO:0045073)2.97151646
75membrane budding (GO:0006900)2.95037766
76negative regulation of nitric oxide biosynthetic process (GO:0045019)2.94634279
77leukocyte aggregation (GO:0070486)2.94122596
78positive regulation of chemokine biosynthetic process (GO:0045080)2.93600107
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92335635
80isotype switching (GO:0045190)2.92335635
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92335635
82regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.91135885
83protein K11-linked deubiquitination (GO:0035871)2.90380151
84response to muramyl dipeptide (GO:0032495)2.88371442
85B cell mediated immunity (GO:0019724)2.87903908
86regulation of interleukin-17 production (GO:0032660)2.87337693
87reactive oxygen species biosynthetic process (GO:1903409)2.86739885
88interferon-gamma production (GO:0032609)2.86638008
89negative regulation of acute inflammatory response (GO:0002674)2.85396978
90synapsis (GO:0007129)2.85363170
91regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.84711491
92respiratory burst (GO:0045730)2.83260096
93C-terminal protein lipidation (GO:0006501)2.78961510
94regulation of mitotic spindle checkpoint (GO:1903504)2.78934891
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78934891
96sequestering of actin monomers (GO:0042989)2.77753398
97positive regulation of interleukin-2 production (GO:0032743)2.77612907
98positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.73908643
99regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.73826644
100regulation of fibroblast apoptotic process (GO:2000269)2.71909002
101positive regulation of antigen processing and presentation (GO:0002579)2.71505947
102positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69807104
103detection of biotic stimulus (GO:0009595)2.69774163
104peptidyl-histidine modification (GO:0018202)2.69374279
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67762718
106regulation of interleukin-12 production (GO:0032655)2.67180781
107macrophage activation involved in immune response (GO:0002281)2.67109194
108prenylation (GO:0097354)2.66083809
109protein prenylation (GO:0018342)2.66083809
110natural killer cell mediated cytotoxicity (GO:0042267)2.65382557
111natural killer cell mediated immunity (GO:0002228)2.65382557
112I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.65217665
113positive regulation of humoral immune response (GO:0002922)2.64505453
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63843425
115negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63101837
116cullin deneddylation (GO:0010388)2.62996563
117signal peptide processing (GO:0006465)2.62564649
118regulation of interleukin-2 biosynthetic process (GO:0045076)2.62532937
119antigen processing and presentation via MHC class Ib (GO:0002475)2.61885670
120regulation of gamma-delta T cell activation (GO:0046643)2.60879817
121RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60874472
122tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60874472
123regulation of natural killer cell activation (GO:0032814)2.60718726
124natural killer cell activation (GO:0030101)2.60082452
125positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59942809
126ribonucleoprotein complex disassembly (GO:0032988)2.59863353
127positive regulation of cytokine biosynthetic process (GO:0042108)2.59336718
128dendritic cell differentiation (GO:0097028)2.58814589
129cellular response to exogenous dsRNA (GO:0071360)2.58525994
130defense response to protozoan (GO:0042832)2.58485478
131positive regulation of B cell differentiation (GO:0045579)2.57571111
132regulation of T cell receptor signaling pathway (GO:0050856)2.56708611
133positive regulation of T-helper cell differentiation (GO:0045624)2.55746570
134positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.54685541
135histone H2A ubiquitination (GO:0033522)2.54588294
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54555434
137wound healing, spreading of epidermal cells (GO:0035313)2.54221030
138negative regulation of signal transduction by p53 class mediator (GO:1901797)2.53536435
139positive regulation of response to biotic stimulus (GO:0002833)2.53145082
140adenosine metabolic process (GO:0046085)2.52678650
141DNA double-strand break processing (GO:0000729)2.48177305
142B cell activation involved in immune response (GO:0002312)2.47100614
143positive regulation of prostaglandin secretion (GO:0032308)2.46843570
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.46552972
145purine-containing compound salvage (GO:0043101)2.46289065
146regulation of protein glycosylation (GO:0060049)2.44518421
147protein deneddylation (GO:0000338)2.44050521
148tryptophan metabolic process (GO:0006568)2.42686792
149C-terminal protein amino acid modification (GO:0018410)2.41966186
150tryptophan catabolic process (GO:0006569)2.40754048
151indole-containing compound catabolic process (GO:0042436)2.40754048
152indolalkylamine catabolic process (GO:0046218)2.40754048
153positive regulation of vasculogenesis (GO:2001214)2.40617512
154protein neddylation (GO:0045116)2.40602490
155respiratory chain complex IV assembly (GO:0008535)2.37392241
156regulation of glucokinase activity (GO:0033131)2.36756464
157regulation of hexokinase activity (GO:1903299)2.36756464
158nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35728178
159negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.34920605
160lactate metabolic process (GO:0006089)2.34817714
161histamine secretion (GO:0001821)2.30803469
162negative regulation of glycoprotein biosynthetic process (GO:0010561)2.27704599
163regulation of B cell receptor signaling pathway (GO:0050855)2.25740126
164kynurenine metabolic process (GO:0070189)2.25087579
165germ cell migration (GO:0008354)2.23508253
166ribosome assembly (GO:0042255)2.23290119
167indolalkylamine metabolic process (GO:0006586)2.23163972
168protein targeting to Golgi (GO:0000042)2.22090887
169purine nucleotide salvage (GO:0032261)2.22001859
170negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.20322225
171inositol phosphate dephosphorylation (GO:0046855)2.20131448
172phosphorylated carbohydrate dephosphorylation (GO:0046838)2.20131448
173cytochrome complex assembly (GO:0017004)2.20053724
174positive regulation of DNA recombination (GO:0045911)2.18444760
175dendritic cell migration (GO:0036336)2.18030698
176histone mRNA metabolic process (GO:0008334)2.17855258
177male meiosis I (GO:0007141)2.17634698
178blood vessel maturation (GO:0001955)2.17349748
179protein K11-linked ubiquitination (GO:0070979)2.17328459
180negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.16152890
181inositol phosphate catabolic process (GO:0071545)2.15233379
182intra-Golgi vesicle-mediated transport (GO:0006891)2.14945209
183exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.14833392
184protein K6-linked ubiquitination (GO:0085020)2.14540974
185positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.14488449
186regulation of prostaglandin secretion (GO:0032306)2.14107697
187mast cell activation (GO:0045576)2.13455500
188dopamine transport (GO:0015872)2.12972176
189glycolipid biosynthetic process (GO:0009247)2.12366857
190regulation of interleukin-8 secretion (GO:2000482)2.12074400
191G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.11870169
192ether lipid metabolic process (GO:0046485)2.10818714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.49748209
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.23272560
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.19464089
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.47486043
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40044197
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.81323313
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.17561546
8GATA1_22025678_ChIP-Seq_K562_Human3.08672755
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06794735
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03069141
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91606553
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88720398
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85680296
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75958624
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.72927146
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70090393
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.69556523
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60407124
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.55292010
20VDR_22108803_ChIP-Seq_LS180_Human2.47733993
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.33692638
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.27140254
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.25103584
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.17811565
25ZNF274_21170338_ChIP-Seq_K562_Hela2.15128345
26* SPI1_23547873_ChIP-Seq_NB4_Human2.05854756
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01783450
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.97435094
29TAF15_26573619_Chip-Seq_HEK293_Human1.96915908
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.88232798
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87393036
32MYB_26560356_Chip-Seq_TH2_Human1.87151868
33FUS_26573619_Chip-Seq_HEK293_Human1.86690777
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86616264
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.85537798
36EWS_26573619_Chip-Seq_HEK293_Human1.82101217
37RUNX_20019798_ChIP-Seq_JUKART_Human1.78908644
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72843908
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68774798
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68488723
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66898383
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65957854
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64268963
44ELK1_19687146_ChIP-ChIP_HELA_Human1.63886788
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.60396246
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60273421
47P300_19829295_ChIP-Seq_ESCs_Human1.60036443
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57277036
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55616890
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54189331
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51901284
52MYB_26560356_Chip-Seq_TH1_Human1.49140264
53PU_27001747_Chip-Seq_BMDM_Mouse1.47174370
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45586604
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45105714
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45038851
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.41762028
58IGF1R_20145208_ChIP-Seq_DFB_Human1.39441405
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37102252
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36458254
61CDX2_22108803_ChIP-Seq_LS180_Human1.35760703
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34934653
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34765969
64GATA3_26560356_Chip-Seq_TH2_Human1.33972892
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33316168
66ER_23166858_ChIP-Seq_MCF-7_Human1.32445297
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32120943
68NANOG_19829295_ChIP-Seq_ESCs_Human1.32071839
69SOX2_19829295_ChIP-Seq_ESCs_Human1.32071839
70FOXP3_21729870_ChIP-Seq_TREG_Human1.31426930
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31139774
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30750740
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30409732
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30120638
75GBX2_23144817_ChIP-Seq_PC3_Human1.29888097
76* GATA2_21666600_ChIP-Seq_HMVEC_Human1.28068788
77GATA3_27048872_Chip-Seq_THYMUS_Human1.27006561
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25616579
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25588575
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.20841955
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20426551
82VDR_24787735_ChIP-Seq_THP-1_Human1.18886700
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18290080
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18251407
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17720887
86SCL_19346495_ChIP-Seq_HPC-7_Human1.16794724
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16563740
88* CBP_20019798_ChIP-Seq_JUKART_Human1.16430254
89* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16430254
90SOX2_20726797_ChIP-Seq_SW620_Human1.16001852
91* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15937925
92SALL4_22934838_ChIP-ChIP_CD34+_Human1.15164456
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.14950250
94* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14542978
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14195214
96BCAT_22108803_ChIP-Seq_LS180_Human1.14169165
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13392870
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13174749
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12728236
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12143676
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12135915
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11705229
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10620453
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09593860
105ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09473705
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09182881
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08997384
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.08907789
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08684071
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08628899
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08587556
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07798783
113P300_18555785_Chip-Seq_ESCs_Mouse1.07431820
114P53_22387025_ChIP-Seq_ESCs_Mouse1.07362047
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.06818835
116MAF_26560356_Chip-Seq_TH1_Human1.05319481
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05044726
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.05044726
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.04833228
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03907842
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03855278
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03275172
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03275172
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03192747
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02602112
126TCF4_22108803_ChIP-Seq_LS180_Human1.02499402
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.02214978
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02138345
129E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02022895
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01988857
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01786786
132GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01407931
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01217327
134ETS1_20019798_ChIP-Seq_JURKAT_Human0.99897464
135* SMAD4_21799915_ChIP-Seq_A2780_Human0.99850124
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98693233
137VDR_24763502_ChIP-Seq_THP-1_Human0.98675919
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.98607085
139E2F7_22180533_ChIP-Seq_HELA_Human0.97663716
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96771205
141SRF_21415370_ChIP-Seq_HL-1_Mouse0.94110663
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93930640
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93930640
144FLI1_27457419_Chip-Seq_LIVER_Mouse0.93116148
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91184437
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.90368946
147SPI1_23127762_ChIP-Seq_K562_Human0.89507496
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89107427
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86783311
150VDR_23849224_ChIP-Seq_CD4+_Human0.83928440
151CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83531236
152CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82646077
153CJUN_26792858_Chip-Seq_BT549_Human0.80825480
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80342580
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80114716
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79619761
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79434042
158KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.79358758
159TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76891576
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76043940
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75674949
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.69631653
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.69588185
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68253440
165UTX_26944678_Chip-Seq_JUKART_Human0.67565356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.28624731
2MP0001835_abnormal_antigen_presentation4.13876607
3MP0009785_altered_susceptibility_to3.86504623
4MP0002148_abnormal_hypersensitivity_rea3.23538647
5MP0000685_abnormal_immune_system3.04309277
6MP0003436_decreased_susceptibility_to2.92627042
7MP0005671_abnormal_response_to2.71891235
8MP0005000_abnormal_immune_tolerance2.70556959
9MP0005025_abnormal_response_to2.61472347
10MP0001790_abnormal_immune_system2.60974280
11MP0005387_immune_system_phenotype2.60974280
12MP0002419_abnormal_innate_immunity2.60592664
13MP0006082_CNS_inflammation2.57099752
14MP0003950_abnormal_plasma_membrane2.52524940
15MP0002006_tumorigenesis2.45386436
16MP0002452_abnormal_antigen_presenting2.27155757
17MP0002166_altered_tumor_susceptibility2.24411859
18MP0002723_abnormal_immune_serum2.19128022
19MP0001800_abnormal_humoral_immune2.17660652
20MP0001819_abnormal_immune_cell2.04166955
21MP0008877_abnormal_DNA_methylation2.02993299
22MP0002420_abnormal_adaptive_immunity2.01648258
23MP0009764_decreased_sensitivity_to1.93770943
24MP0003806_abnormal_nucleotide_metabolis1.88456942
25MP0008058_abnormal_DNA_repair1.80912525
26MP0002877_abnormal_melanocyte_morpholog1.79677865
27MP0001853_heart_inflammation1.79649820
28MP0002138_abnormal_hepatobiliary_system1.78445636
29MP0001533_abnormal_skeleton_physiology1.77952355
30MP0004947_skin_inflammation1.74971446
31MP0010234_abnormal_vibrissa_follicle1.71587566
32MP0006072_abnormal_retinal_apoptosis1.71170260
33MP0002405_respiratory_system_inflammati1.70620744
34MP0002254_reproductive_system_inflammat1.69456414
35MP0001845_abnormal_inflammatory_respons1.69364216
36MP0003763_abnormal_thymus_physiology1.63960124
37MP0003252_abnormal_bile_duct1.62175778
38MP0002102_abnormal_ear_morphology1.60339404
39MP0010155_abnormal_intestine_physiology1.57157156
40MP0009333_abnormal_splenocyte_physiolog1.56327877
41MP0002139_abnormal_hepatobiliary_system1.56134652
42MP0000858_altered_metastatic_potential1.56032140
43MP0003448_altered_tumor_morphology1.54982655
44MP0008469_abnormal_protein_level1.54212260
45MP0010678_abnormal_skin_adnexa1.49641612
46MP0006054_spinal_hemorrhage1.48557903
47MP0005075_abnormal_melanosome_morpholog1.48553822
48MP0000716_abnormal_immune_system1.48322005
49MP0001879_abnormal_lymphatic_vessel1.48235706
50MP0004510_myositis1.47544599
51MP0005084_abnormal_gallbladder_morpholo1.46661974
52MP0008057_abnormal_DNA_replication1.45050144
53MP0002398_abnormal_bone_marrow1.44966773
54MP0005464_abnormal_platelet_physiology1.40958584
55MP0002876_abnormal_thyroid_physiology1.38127731
56MP0000343_altered_response_to1.36935889
57MP0003191_abnormal_cellular_cholesterol1.36550576
58MP0003828_pulmonary_edema1.36376206
59MP0004782_abnormal_surfactant_physiolog1.34034094
60MP0002837_dystrophic_cardiac_calcinosis1.29599175
61MP0003186_abnormal_redox_activity1.26907999
62MP0002132_abnormal_respiratory_system1.25742449
63MP0002277_abnormal_respiratory_mucosa1.23899577
64MP0003656_abnormal_erythrocyte_physiolo1.22298914
65MP0001545_abnormal_hematopoietic_system1.22028532
66MP0005397_hematopoietic_system_phenotyp1.22028532
67MP0006036_abnormal_mitochondrial_physio1.19505850
68MP0002429_abnormal_blood_cell1.19021070
69MP0003303_peritoneal_inflammation1.17322537
70MP0005310_abnormal_salivary_gland1.17274883
71MP0002163_abnormal_gland_morphology1.16541327
72MP0002998_abnormal_bone_remodeling1.16478602
73MP0000689_abnormal_spleen_morphology1.16340962
74MP0005058_abnormal_lysosome_morphology1.16284997
75MP0001873_stomach_inflammation1.15899911
76MP0002722_abnormal_immune_system1.12490254
77MP0005253_abnormal_eye_physiology1.11589580
78MP0010386_abnormal_urinary_bladder1.08511462
79MP0003718_maternal_effect1.08075314
80MP0005367_renal/urinary_system_phenotyp1.05727541
81MP0000516_abnormal_urinary_system1.05727541
82MP0002095_abnormal_skin_pigmentation1.04827842
83MP0005164_abnormal_response_to1.04648171
84MP0000569_abnormal_digit_pigmentation1.03906754
85MP0004484_altered_response_of1.03559858
86MP0000465_gastrointestinal_hemorrhage1.03280758
87MP0002933_joint_inflammation1.02539206
88MP0003786_premature_aging1.00878773
89MP0009278_abnormal_bone_marrow0.98975568
90MP0004808_abnormal_hematopoietic_stem0.98945660
91MP0000427_abnormal_hair_cycle0.98856692
92MP0005167_abnormal_blood-brain_barrier0.97487983
93MP0000767_abnormal_smooth_muscle0.97215127
94MP0005390_skeleton_phenotype0.97164817
95MP0002396_abnormal_hematopoietic_system0.96620570
96MP0001851_eye_inflammation0.96091943
97MP0005410_abnormal_fertilization0.95470850
98MP0010368_abnormal_lymphatic_system0.94848425
99MP0002693_abnormal_pancreas_physiology0.93872324
100MP0005166_decreased_susceptibility_to0.93624742
101MP0006035_abnormal_mitochondrial_morpho0.92830182
102MP0008007_abnormal_cellular_replicative0.92273772
103MP0005275_abnormal_skin_tensile0.91541546
104MP0000249_abnormal_blood_vessel0.91014555
105MP0000383_abnormal_hair_follicle0.90227529
106MP0002009_preneoplasia0.88724182
107MP0003300_gastrointestinal_ulcer0.87645961
108MP0009763_increased_sensitivity_to0.86529977
109MP0005379_endocrine/exocrine_gland_phen0.86189970
110MP0004147_increased_porphyrin_level0.85659146
111MP0000372_irregular_coat_pigmentation0.81081352
112MP0001764_abnormal_homeostasis0.80436542
113MP0009780_abnormal_chondrocyte_physiolo0.80322502
114MP0004134_abnormal_chest_morphology0.78809777
115MP0008260_abnormal_autophagy0.78356028
116MP0003183_abnormal_peptide_metabolism0.78022521
117MP0003566_abnormal_cell_adhesion0.77539484
118MP0000703_abnormal_thymus_morphology0.77367210
119MP0003075_altered_response_to0.76969149
120MP0004215_abnormal_myocardial_fiber0.76860487
121MP0001881_abnormal_mammary_gland0.76039955
122MP0003195_calcinosis0.71961303
123MP0004883_abnormal_blood_vessel0.71095827
124MP0003795_abnormal_bone_structure0.70933609
125MP0001191_abnormal_skin_condition0.69518922
126MP0009697_abnormal_copulation0.67067752
127MP0010352_gastrointestinal_tract_polyps0.64146699
128MP0003453_abnormal_keratinocyte_physiol0.63333041
129MP0008438_abnormal_cutaneous_collagen0.63265680
130MP0003045_fibrosis0.62707711
131MP0005174_abnormal_tail_pigmentation0.61353368
132MP0000015_abnormal_ear_pigmentation0.60336665
133MP0005408_hypopigmentation0.58623868
134MP0002019_abnormal_tumor_incidence0.58571981
135MP0000627_abnormal_mammary_gland0.58010139
136MP0003866_abnormal_defecation0.57374599

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.76282419
2Recurrent abscess formation (HP:0002722)5.36433783
3Myositis (HP:0100614)4.87202254
4Orchitis (HP:0100796)4.76198465
5Recurrent bacterial skin infections (HP:0005406)4.72917957
6Retrobulbar optic neuritis (HP:0100654)4.66095608
7Optic neuritis (HP:0100653)4.66095608
8Elevated erythrocyte sedimentation rate (HP:0003565)4.58226021
9Recurrent gram-negative bacterial infections (HP:0005420)4.36485196
10Mediastinal lymphadenopathy (HP:0100721)3.80689516
11Increased IgM level (HP:0003496)3.60578822
12Abnormality of macrophages (HP:0004311)3.58846131
13Recurrent fungal infections (HP:0002841)3.53796553
14Autoimmune thrombocytopenia (HP:0001973)3.45266995
15Vacuolated lymphocytes (HP:0001922)3.28431921
16Metaphyseal dysplasia (HP:0100255)3.18361584
17Recurrent skin infections (HP:0001581)3.17193309
18Vasculitis (HP:0002633)3.16410952
19Recurrent viral infections (HP:0004429)3.14189792
20Type I transferrin isoform profile (HP:0003642)3.11016662
21Eosinophilia (HP:0001880)3.05907025
22Periodontitis (HP:0000704)3.01652544
23Keratoconjunctivitis sicca (HP:0001097)3.00853209
24Pulmonary infiltrates (HP:0002113)2.94795760
25Stomatitis (HP:0010280)2.93241479
26Vertebral compression fractures (HP:0002953)2.92897387
27Hypergammaglobulinemia (HP:0010702)2.92809751
28Abnormality of the prostate (HP:0008775)2.91584950
29Hemoptysis (HP:0002105)2.90593271
30Gingivitis (HP:0000230)2.86814735
31Abnormal protein glycosylation (HP:0012346)2.83922726
32Abnormal glycosylation (HP:0012345)2.83922726
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.83922726
34Abnormal protein N-linked glycosylation (HP:0012347)2.83922726
35Keratoconjunctivitis (HP:0001096)2.83797216
36Stomach cancer (HP:0012126)2.81367965
37Arterial thrombosis (HP:0004420)2.80531475
38Basal ganglia calcification (HP:0002135)2.79687347
39Interstitial pulmonary disease (HP:0006530)2.78920923
40Methylmalonic acidemia (HP:0002912)2.75048696
41Abnormality of liposaccharide metabolism (HP:0010968)2.68790741
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.68790741
43Abnormality of glycolipid metabolism (HP:0010969)2.68790741
44Volvulus (HP:0002580)2.64627701
45Granulocytopenia (HP:0001913)2.63438565
46Gastrointestinal infarctions (HP:0005244)2.62083031
47Recurrent cutaneous fungal infections (HP:0011370)2.61243235
48Chronic mucocutaneous candidiasis (HP:0002728)2.61243235
49Obstructive lung disease (HP:0006536)2.59398322
50Chronic obstructive pulmonary disease (HP:0006510)2.59398322
51Leukocytosis (HP:0001974)2.59017063
52Joint swelling (HP:0001386)2.54444551
53Systemic lupus erythematosus (HP:0002725)2.54348745
54Abnormality of eosinophils (HP:0001879)2.50696450
553-Methylglutaconic aciduria (HP:0003535)2.48946884
56Abnormality of T cell number (HP:0011839)2.47349129
57Syringomyelia (HP:0003396)2.46008893
58Spinal cord lesions (HP:0100561)2.46008893
59Meningitis (HP:0001287)2.43578827
60Renal cortical cysts (HP:0000803)2.39543919
61Autoimmune hemolytic anemia (HP:0001890)2.38105203
62Tetraparesis (HP:0002273)2.34164031
63Progressive macrocephaly (HP:0004481)2.32376881
64Thyroiditis (HP:0100646)2.32359066
65Thrombocytosis (HP:0001894)2.29143904
66Methylmalonic aciduria (HP:0012120)2.28149814
67Aplastic anemia (HP:0001915)2.27562675
68Spontaneous hematomas (HP:0007420)2.24772385
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.24548632
70Increased CSF lactate (HP:0002490)2.20858551
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.19269896
72Abnormality of the nasal mucosa (HP:0000433)2.18616058
73Gangrene (HP:0100758)2.18042678
74Encephalitis (HP:0002383)2.17824925
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16141951
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16141951
77Urticaria (HP:0001025)2.15647149
78IgM deficiency (HP:0002850)2.14098473
79Progressive inability to walk (HP:0002505)2.14046702
80Severe combined immunodeficiency (HP:0004430)2.12169467
81Osteomyelitis (HP:0002754)2.12019790
82Recurrent pneumonia (HP:0006532)2.11857744
83Abnormality of T cells (HP:0002843)2.11123966
84T lymphocytopenia (HP:0005403)2.10377378
85Chronic otitis media (HP:0000389)2.09151337
86Petechiae (HP:0000967)2.09029282
87Mitochondrial inheritance (HP:0001427)2.08685894
88Abnormal spermatogenesis (HP:0008669)2.08355105
89Acute necrotizing encephalopathy (HP:0006965)2.08212331
90Anorexia (HP:0002039)2.06929694
91Anhidrosis (HP:0000970)2.06664595
92Increased IgE level (HP:0003212)2.05517663
93Abnormality of T cell physiology (HP:0011840)2.05270998
94Abnormality of the renal cortex (HP:0011035)2.04509745
95Parakeratosis (HP:0001036)2.02365820
96Hypothermia (HP:0002045)2.01302298
97Recurrent bronchitis (HP:0002837)2.01080568
98Attenuation of retinal blood vessels (HP:0007843)2.00920280
99Abnormality of B cell number (HP:0010975)2.00497676
100B lymphocytopenia (HP:0010976)2.00497676
101Abnormality of the pericardium (HP:0001697)2.00118732
102Constricted visual fields (HP:0001133)1.99712753
103Short tibia (HP:0005736)1.99242747
104Cellulitis (HP:0100658)1.98743845
105Abnormality of methionine metabolism (HP:0010901)1.97215260
106Thyroid-stimulating hormone excess (HP:0002925)1.97166640
107Purpura (HP:0000979)1.96661589
108Myocardial infarction (HP:0001658)1.95646222
109Molar tooth sign on MRI (HP:0002419)1.95520493
110Abnormality of midbrain morphology (HP:0002418)1.95520493
111Pustule (HP:0200039)1.95311942
112Spondylolisthesis (HP:0003302)1.95280803
113Keratitis (HP:0000491)1.94221138
114Nasal polyposis (HP:0100582)1.93509111
115Combined immunodeficiency (HP:0005387)1.93068728
116Abnormality of the axillary hair (HP:0100134)1.92153396
117Abnormality of secondary sexual hair (HP:0009888)1.92153396
118Increased hepatocellular lipid droplets (HP:0006565)1.92151745
119Hypoproteinemia (HP:0003075)1.91689347
120Median cleft lip (HP:0000161)1.91593701
121Increased cerebral lipofuscin (HP:0011813)1.91086264
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.90949483
123Osteolytic defects of the hand bones (HP:0009699)1.90366195
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.90366195
125Prostate neoplasm (HP:0100787)1.90296302
126Reduced antithrombin III activity (HP:0001976)1.89005144
127Medial flaring of the eyebrow (HP:0010747)1.88957974
128IgG deficiency (HP:0004315)1.88783859
129Cerebral edema (HP:0002181)1.88691918
130Abnormality of the pleura (HP:0002103)1.87540741
131Short middle phalanx of the 5th finger (HP:0004220)1.87442695
132Chronic diarrhea (HP:0002028)1.87433566
133Azoospermia (HP:0000027)1.87098299
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86832135
135Neonatal respiratory distress (HP:0002643)1.86368089
136Poor head control (HP:0002421)1.85619374
137Hepatic necrosis (HP:0002605)1.85488743
138Facial diplegia (HP:0001349)1.84887717
139Esophageal neoplasm (HP:0100751)1.84482909
140Neoplasm of head and neck (HP:0012288)1.84482909
141Reduced subcutaneous adipose tissue (HP:0003758)1.84313508
142Alveolar cell carcinoma (HP:0006519)1.83794895
143Cutaneous melanoma (HP:0012056)1.83500750
144Recurrent lower respiratory tract infections (HP:0002783)1.83287717
145Neutropenia (HP:0001875)1.82969750
146Hematochezia (HP:0002573)1.82350963
147Glomerulopathy (HP:0100820)1.82312002
148Fair hair (HP:0002286)1.80920367
149Absent speech (HP:0001344)1.80692117
150Hypoplasia of the thymus (HP:0000778)1.80086728
151Hepatocellular necrosis (HP:0001404)1.79622380
152Pancreatic cysts (HP:0001737)1.78557534
153Abnormality of vitamin B metabolism (HP:0004340)1.77910120
154Skin ulcer (HP:0200042)1.77739981
155Arthralgia (HP:0002829)1.77260538
156Abnormal mitochondria in muscle tissue (HP:0008316)1.77209565
157Intestinal atresia (HP:0011100)1.76798473
158Increased serum lactate (HP:0002151)1.74469224
159Abnormality of chromosome stability (HP:0003220)1.73005801
160Conjunctival hamartoma (HP:0100780)1.71612586
161Acute encephalopathy (HP:0006846)1.70984063
162Widely spaced teeth (HP:0000687)1.70953612
163Abolished electroretinogram (ERG) (HP:0000550)1.69722115
164Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69111706
165Lipid accumulation in hepatocytes (HP:0006561)1.68489829
166Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.68228995
167Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67702775
168Congenital, generalized hypertrichosis (HP:0004540)1.66937581
169Pancreatic islet-cell hyperplasia (HP:0004510)1.66665674
170Albinism (HP:0001022)1.65992419
171Patchy hypopigmentation of hair (HP:0011365)1.64904039
172Neoplasm of the tracheobronchial system (HP:0100552)1.64283426
173Abnormality of the vitamin B12 metabolism (HP:0004341)1.64164703
174Hyperalaninemia (HP:0003348)1.63435674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.48790361
2TXK3.30327251
3JAK33.05169559
4TYK22.87831124
5MAP4K22.69203626
6MST42.41569648
7TBK12.40414868
8IKBKE2.34553913
9IRAK32.22433242
10MAP4K12.17481653
11EIF2AK32.10357572
12IRAK42.04249407
13TRIM282.00540502
14IKBKB1.97553836
15KDR1.88386614
16JAK11.84450549
17RIPK41.84161218
18PIM21.83476190
19PINK11.80420670
20ZAP701.80157913
21KIT1.78346216
22PLK41.74729199
23FLT31.72780032
24TGFBR21.72266510
25BLK1.69903908
26ERN11.67786124
27BCKDK1.65698103
28EPHA31.60135899
29CHUK1.57180105
30TEC1.56119895
31ACVR1B1.55001145
32GRK11.53371840
33PLK21.46923987
34PBK1.44258834
35FGFR41.42505279
36TIE11.41379992
37WNK31.41294199
38PIK3CG1.35047857
39NLK1.34210959
40BMPR21.32662521
41EIF2AK21.32438061
42NEK91.31524162
43BTK1.28400799
44TAOK31.26538182
45ERBB31.25044626
46FGFR31.22571444
47CSK1.22497361
48MAP3K31.20713007
49SYK1.13704248
50MAP3K131.11838598
51TGFBR11.09649495
52NUAK11.06241762
53MAP3K121.04400641
54LCK1.01420938
55RPS6KA40.99328216
56EPHB10.99104827
57STK38L0.98452164
58NME20.97766826
59YES10.97282818
60FER0.94420233
61BUB10.93909114
62LYN0.93477394
63PIM10.92340345
64STK100.88446833
65INSRR0.85127006
66PRKCE0.84980705
67RIPK10.83900542
68HCK0.83567955
69STK390.82034058
70JAK20.81933944
71CSNK1G10.81141815
72PDK20.80584988
73PLK30.79114120
74MUSK0.78973114
75MYLK0.78651346
76NEK10.77794055
77ITK0.77615070
78STK240.77076233
79SRPK10.76536619
80FRK0.75059982
81OXSR10.73444442
82TNIK0.73067296
83MKNK10.72398881
84PTK60.71970545
85CSF1R0.70976640
86BRSK20.70360426
87PRKG20.69940214
88MARK30.67515532
89CSNK1G30.64985307
90TESK10.64966165
91STK30.64673875
92CAMKK20.63146962
93BCR0.62765943
94IRAK10.62012872
95CSNK1G20.60545200
96MATK0.60048769
97PRKCD0.58609838
98MST1R0.57443657
99GRK60.57320803
100TRPM70.57172231
101MKNK20.56938149
102ADRBK20.56934877
103ZAK0.56400838
104MAPK130.54153279
105RPS6KA50.53731940
106GRK70.53047503
107BMPR1B0.52576919
108DYRK30.51360501
109ADRBK10.50649234
110PRKCQ0.50177281
111MAPKAPK50.49398536
112CDK80.49374506
113PASK0.49341562
114VRK10.49318651
115MAPKAPK30.48078828
116MAPKAPK20.47874388
117EGFR0.46844225
118IGF1R0.46122060
119EIF2AK10.45233275
120* ABL10.45187351
121STK40.44335931
122NEK60.41564493
123OBSCN0.41563498
124FES0.38439154
125CDK60.36101851
126SIK30.35779032
127CSNK1A1L0.33662645
128CDK190.32953548
129ATM0.32213123
130WEE10.31652557
131MAP2K30.29300055
132LRRK20.26745615
133ABL20.26126456
134EPHA20.25845119
135PTK2B0.25025791
136MOS0.25019416

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.84443023
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.00185455
3Allograft rejection_Homo sapiens_hsa053302.90272215
4Legionellosis_Homo sapiens_hsa051342.86647122
5Leishmaniasis_Homo sapiens_hsa051402.82282861
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.77753554
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58245106
8Type I diabetes mellitus_Homo sapiens_hsa049402.53331100
9Malaria_Homo sapiens_hsa051442.41164756
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.40097161
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38591389
12Measles_Homo sapiens_hsa051622.38508768
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33127156
14Rheumatoid arthritis_Homo sapiens_hsa053232.26633852
15Staphylococcus aureus infection_Homo sapiens_hsa051502.18917612
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.18292856
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.17387554
18Sulfur metabolism_Homo sapiens_hsa009202.10081262
19Propanoate metabolism_Homo sapiens_hsa006402.09812815
20Antigen processing and presentation_Homo sapiens_hsa046122.08938630
21Pertussis_Homo sapiens_hsa051332.04269912
22Proteasome_Homo sapiens_hsa030501.84959838
23Osteoclast differentiation_Homo sapiens_hsa043801.82001501
24Protein export_Homo sapiens_hsa030601.81854443
25Influenza A_Homo sapiens_hsa051641.79554716
26Primary immunodeficiency_Homo sapiens_hsa053401.78819381
27Herpes simplex infection_Homo sapiens_hsa051681.77926084
28TNF signaling pathway_Homo sapiens_hsa046681.76512923
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74187175
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74058664
31Regulation of autophagy_Homo sapiens_hsa041401.69402029
32Homologous recombination_Homo sapiens_hsa034401.67666598
33Tuberculosis_Homo sapiens_hsa051521.67275778
34Nitrogen metabolism_Homo sapiens_hsa009101.65606165
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63683791
36Fatty acid elongation_Homo sapiens_hsa000621.62023674
37Oxidative phosphorylation_Homo sapiens_hsa001901.61011422
38Hematopoietic cell lineage_Homo sapiens_hsa046401.60991412
39African trypanosomiasis_Homo sapiens_hsa051431.59811540
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58089499
41Autoimmune thyroid disease_Homo sapiens_hsa053201.57897179
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56742828
43Phototransduction_Homo sapiens_hsa047441.51086020
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.48561354
45Fanconi anemia pathway_Homo sapiens_hsa034601.47980285
46Toxoplasmosis_Homo sapiens_hsa051451.42235122
47Circadian rhythm_Homo sapiens_hsa047101.38762070
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34239546
49Asthma_Homo sapiens_hsa053101.33320944
50Salmonella infection_Homo sapiens_hsa051321.33317249
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32823223
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31291868
53RNA degradation_Homo sapiens_hsa030181.30803893
54Phagosome_Homo sapiens_hsa041451.25935544
55Apoptosis_Homo sapiens_hsa042101.20753732
56Nucleotide excision repair_Homo sapiens_hsa034201.19320208
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18790130
58Parkinsons disease_Homo sapiens_hsa050121.18176788
59Hepatitis B_Homo sapiens_hsa051611.17458691
60Shigellosis_Homo sapiens_hsa051311.15111777
61Butanoate metabolism_Homo sapiens_hsa006501.11124982
62Tryptophan metabolism_Homo sapiens_hsa003801.11105426
63Viral myocarditis_Homo sapiens_hsa054161.10709362
64Steroid biosynthesis_Homo sapiens_hsa001001.06193930
65RNA polymerase_Homo sapiens_hsa030201.05597373
66Collecting duct acid secretion_Homo sapiens_hsa049661.04026025
67Mismatch repair_Homo sapiens_hsa034301.03786362
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01998998
69* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01383274
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.98806009
71Chemokine signaling pathway_Homo sapiens_hsa040620.96440450
72Selenocompound metabolism_Homo sapiens_hsa004500.95771654
73Other glycan degradation_Homo sapiens_hsa005110.95671244
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94008604
75Lysosome_Homo sapiens_hsa041420.92665552
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91380820
77Hepatitis C_Homo sapiens_hsa051600.91143842
78Ether lipid metabolism_Homo sapiens_hsa005650.90869021
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.89913527
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87188504
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86465026
82B cell receptor signaling pathway_Homo sapiens_hsa046620.80140931
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78439906
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73944995
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73912797
86Linoleic acid metabolism_Homo sapiens_hsa005910.71523857
87Epstein-Barr virus infection_Homo sapiens_hsa051690.70968930
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.70813800
89Peroxisome_Homo sapiens_hsa041460.70430118
90RNA transport_Homo sapiens_hsa030130.70357446
91Chemical carcinogenesis_Homo sapiens_hsa052040.69804479
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.63335194
93Acute myeloid leukemia_Homo sapiens_hsa052210.61308209
94Amoebiasis_Homo sapiens_hsa051460.61224522
95Retinol metabolism_Homo sapiens_hsa008300.59765606
96p53 signaling pathway_Homo sapiens_hsa041150.59764194
97Glutathione metabolism_Homo sapiens_hsa004800.59275887
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58869405
99Complement and coagulation cascades_Homo sapiens_hsa046100.56908034
100Caffeine metabolism_Homo sapiens_hsa002320.56510792
101Fatty acid degradation_Homo sapiens_hsa000710.55971840
102* T cell receptor signaling pathway_Homo sapiens_hsa046600.55401037
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54518221
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54375818
105Prolactin signaling pathway_Homo sapiens_hsa049170.54257972
106Non-homologous end-joining_Homo sapiens_hsa034500.53785283
107Alzheimers disease_Homo sapiens_hsa050100.53306425
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50905422
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50548308
110Thyroid cancer_Homo sapiens_hsa052160.49012481
111Viral carcinogenesis_Homo sapiens_hsa052030.48913490
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48254062
113Folate biosynthesis_Homo sapiens_hsa007900.47959709
114Platelet activation_Homo sapiens_hsa046110.47828977
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47423606
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46496903
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.44511406
118HTLV-I infection_Homo sapiens_hsa051660.44188074
119Small cell lung cancer_Homo sapiens_hsa052220.43871184
120Metabolic pathways_Homo sapiens_hsa011000.43518218
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.43321994
122Purine metabolism_Homo sapiens_hsa002300.42472791
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41664741
124Arachidonic acid metabolism_Homo sapiens_hsa005900.41313909
125Huntingtons disease_Homo sapiens_hsa050160.40877047
126Spliceosome_Homo sapiens_hsa030400.39022435
127Vibrio cholerae infection_Homo sapiens_hsa051100.38569940
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38186457
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36964422
130Sphingolipid metabolism_Homo sapiens_hsa006000.36627202
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33496789
132Ribosome_Homo sapiens_hsa030100.33267001
133HIF-1 signaling pathway_Homo sapiens_hsa040660.32225196
134Prion diseases_Homo sapiens_hsa050200.32107215
135Basal transcription factors_Homo sapiens_hsa030220.30243834
136DNA replication_Homo sapiens_hsa030300.24583193
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24564738
138Pyrimidine metabolism_Homo sapiens_hsa002400.24019839
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22838984
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21781737
141Pancreatic cancer_Homo sapiens_hsa052120.21578471
142Base excision repair_Homo sapiens_hsa034100.18706294
143Adherens junction_Homo sapiens_hsa045200.18277543
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.17649910
145Galactose metabolism_Homo sapiens_hsa000520.15572941
146Insulin resistance_Homo sapiens_hsa049310.14486798
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13179824
148Chronic myeloid leukemia_Homo sapiens_hsa052200.13027352
149N-Glycan biosynthesis_Homo sapiens_hsa005100.12220889
150FoxO signaling pathway_Homo sapiens_hsa040680.11931493
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11790415

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