NCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1megakaryocyte development (GO:0035855)4.58396876
2positive regulation of gamma-delta T cell activation (GO:0046645)4.03152814
3diterpenoid biosynthetic process (GO:0016102)3.92826043
4negative regulation of cell killing (GO:0031342)3.80982368
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.80982368
6endocardial cushion morphogenesis (GO:0003203)3.77818006
7RNA localization (GO:0006403)3.72921142
8mesenchyme morphogenesis (GO:0072132)3.67041582
9negative regulation of erythrocyte differentiation (GO:0045647)3.61831391
10heart valve formation (GO:0003188)3.59819542
11neural crest cell development (GO:0014032)3.52672617
12metanephric mesenchyme development (GO:0072075)3.45261731
13ganglion development (GO:0061548)3.44266597
14heart valve morphogenesis (GO:0003179)3.43369345
15negative regulation of keratinocyte proliferation (GO:0010839)3.42446544
16cardiac right ventricle morphogenesis (GO:0003215)3.41094365
17regulation of gamma-delta T cell activation (GO:0046643)3.36403888
18tolerance induction (GO:0002507)3.34942852
19neutrophil activation involved in immune response (GO:0002283)3.34904413
20regulation of gamma-delta T cell differentiation (GO:0045586)3.30725431
21platelet formation (GO:0030220)3.30688307
22Notch signaling involved in heart development (GO:0061314)3.28524530
23regulation of male gonad development (GO:2000018)3.28521653
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.24639445
25modulation by symbiont of host immune response (GO:0052553)3.24639445
26positive regulation by symbiont of host defense response (GO:0052509)3.24639445
27modulation by symbiont of host defense response (GO:0052031)3.24639445
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24639445
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24639445
30positive regulation of macrophage differentiation (GO:0045651)3.18711258
31mesenchymal cell development (GO:0014031)3.18074236
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15162421
33thrombin receptor signaling pathway (GO:0070493)3.12177453
34regulation of platelet aggregation (GO:0090330)3.11935510
35kidney mesenchyme development (GO:0072074)3.11555333
36angiogenesis involved in wound healing (GO:0060055)3.11032478
37thymic T cell selection (GO:0045061)3.06489077
38glomerulus development (GO:0032835)3.04768748
39positive regulation of mast cell activation (GO:0033005)3.03596614
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03138106
41positive regulation of male gonad development (GO:2000020)3.01478424
42regulation of cardioblast proliferation (GO:0003264)3.00799700
43regulation of secondary heart field cardioblast proliferation (GO:0003266)3.00799700
44adenosine receptor signaling pathway (GO:0001973)2.96956583
45macrophage activation involved in immune response (GO:0002281)2.93426575
46cell differentiation involved in metanephros development (GO:0072202)2.87217945
47regulation of necroptotic process (GO:0060544)2.86653210
48cellular extravasation (GO:0045123)2.86208178
49desmosome organization (GO:0002934)2.82955713
50negative regulation of homotypic cell-cell adhesion (GO:0034111)2.77016395
51antigen processing and presentation of endogenous antigen (GO:0019883)2.76587700
52regulation of heart morphogenesis (GO:2000826)2.76158803
53sympathetic nervous system development (GO:0048485)2.73079105
54atrioventricular valve morphogenesis (GO:0003181)2.73034530
55stem cell development (GO:0048864)2.72693866
56negative regulation of cell fate specification (GO:0009996)2.70338442
57B cell receptor signaling pathway (GO:0050853)2.70179994
58response to prostaglandin E (GO:0034695)2.69121660
59proximal/distal pattern formation (GO:0009954)2.68928520
60response to muramyl dipeptide (GO:0032495)2.67719798
61negative regulation of T cell mediated immunity (GO:0002710)2.67640615
62regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.67517591
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64487481
64negative thymic T cell selection (GO:0045060)2.63233548
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61836746
66negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61430007
67myoblast migration (GO:0051451)2.61058929
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60082335
69* signal complex assembly (GO:0007172)2.59717233
70dendritic cell chemotaxis (GO:0002407)2.59152245
71detection of other organism (GO:0098543)2.58506404
72positive regulation of mast cell activation involved in immune response (GO:0033008)2.57913051
73positive regulation of mast cell degranulation (GO:0043306)2.57913051
74germinal center formation (GO:0002467)2.57549931
75terpenoid biosynthetic process (GO:0016114)2.57042440
76detection of bacterium (GO:0016045)2.55934990
77atrial septum morphogenesis (GO:0060413)2.54848704
78neutrophil activation (GO:0042119)2.53946426
79regulation of B cell differentiation (GO:0045577)2.53889215
80CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.53662722
81T-helper cell differentiation (GO:0042093)2.53662722
82regulation of T-helper 1 cell differentiation (GO:0045625)2.51501126
83limb bud formation (GO:0060174)2.50791423
84dendritic cell migration (GO:0036336)2.50150062
85kidney morphogenesis (GO:0060993)2.49586299
86face development (GO:0060324)2.48998955
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47790755
88activation of JUN kinase activity (GO:0007257)2.45856575
89regulation of mast cell degranulation (GO:0043304)2.45759177
90ventricular trabecula myocardium morphogenesis (GO:0003222)2.45424037
91regulation of cell proliferation involved in kidney development (GO:1901722)2.45395985
92fat-soluble vitamin catabolic process (GO:0042363)2.45241608
93vitamin catabolic process (GO:0009111)2.45241608
94glomerular visceral epithelial cell development (GO:0072015)2.44795408
95G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.43835821
96regulation of regulatory T cell differentiation (GO:0045589)2.43710100
97leukocyte aggregation (GO:0070486)2.42556820
98regulation of early endosome to late endosome transport (GO:2000641)2.42520592
99positive regulation of type 2 immune response (GO:0002830)2.42458693
100regulation of necrotic cell death (GO:0010939)2.41618753
101histone H3-K36 demethylation (GO:0070544)2.40988540
102regulation of NFAT protein import into nucleus (GO:0051532)2.40610839
103positive thymic T cell selection (GO:0045059)2.40568019
104negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40495896
105cell surface receptor signaling pathway involved in heart development (GO:0061311)2.40153057
106outer ear morphogenesis (GO:0042473)2.39613658
107regulation of chemokine biosynthetic process (GO:0045073)2.39536930
108response to laminar fluid shear stress (GO:0034616)2.38894363
109positive regulation of T-helper cell differentiation (GO:0045624)2.38463808
110modulation by symbiont of host cellular process (GO:0044068)2.38316268
111T-helper 1 type immune response (GO:0042088)2.36460429
112regulation of leukocyte degranulation (GO:0043300)2.35619176
113production of molecular mediator involved in inflammatory response (GO:0002532)2.34701212
114positive regulation of histone deacetylation (GO:0031065)2.33580669
115G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.32977221
116lipoxygenase pathway (GO:0019372)2.32842980
117regulation of T cell chemotaxis (GO:0010819)2.32822933
118positive regulation of T cell chemotaxis (GO:0010820)2.32822933
119mammary gland development (GO:0030879)2.32514025
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.31286336
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31109811
122positive regulation of natural killer cell differentiation (GO:0032825)2.30896796
123aorta morphogenesis (GO:0035909)2.30375484
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30015202
125negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.26895194
126positive regulation of leukocyte degranulation (GO:0043302)2.26792548
127negative T cell selection (GO:0043383)2.25985562
128regulation of T cell tolerance induction (GO:0002664)2.25802125
129response to peptidoglycan (GO:0032494)2.25368427
130regulation of extracellular matrix disassembly (GO:0010715)2.25273175
131regulation of tolerance induction (GO:0002643)2.24986086
132positive regulation of myoblast differentiation (GO:0045663)2.24467407
133T cell migration (GO:0072678)2.24107676
134regulation of B cell receptor signaling pathway (GO:0050855)2.24019672
135hepatocyte apoptotic process (GO:0097284)2.23064180
136stress fiber assembly (GO:0043149)2.22932426
137microglial cell activation (GO:0001774)2.22788265
138dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22599091
139regulation of homotypic cell-cell adhesion (GO:0034110)2.22441188
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.22422077
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.21930454
142negative regulation of stem cell proliferation (GO:2000647)2.21519031
143cardiac ventricle morphogenesis (GO:0003208)2.21395160
144positive regulation of tolerance induction (GO:0002645)2.21102313
145modulation by virus of host process (GO:0019054)2.21055047
146regulation of platelet activation (GO:0010543)2.20569686
147regulation of T-helper 2 cell differentiation (GO:0045628)2.20373246
148regulation of cell fate specification (GO:0042659)2.20050245
149fibril organization (GO:0097435)2.19378418
150morphogenesis of an epithelial sheet (GO:0002011)2.18914003
151establishment of skin barrier (GO:0061436)2.18899090
152cellular response to vitamin D (GO:0071305)2.18528556
153embryonic camera-type eye development (GO:0031076)2.18286781
154cell-cell junction maintenance (GO:0045217)2.18056675
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.17765798
156positive regulation of isotype switching (GO:0045830)2.17558820
157positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.17379740
158negative regulation of stress fiber assembly (GO:0051497)2.17235420
159glomerular epithelial cell development (GO:0072310)2.16775349
160myeloid cell development (GO:0061515)2.15954331
161regulation of natural killer cell mediated immunity (GO:0002715)2.15864003
162regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.15864003
163positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.14608798
164macrophage activation (GO:0042116)2.14484515
165negative regulation of striated muscle cell apoptotic process (GO:0010664)2.13510575
166regulation of glomerulus development (GO:0090192)2.13405797
167regulation of water loss via skin (GO:0033561)2.13367800
168facial nerve structural organization (GO:0021612)2.12867308
169T cell differentiation involved in immune response (GO:0002292)2.11923263
170alpha-beta T cell differentiation involved in immune response (GO:0002293)2.11923263
171alpha-beta T cell activation involved in immune response (GO:0002287)2.11923263
172T cell selection (GO:0045058)2.11620344
173epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.11527070
174cardiac chamber formation (GO:0003207)2.11063017
175cardiac ventricle formation (GO:0003211)2.10828753
176regulation of cardioblast differentiation (GO:0051890)2.10709718
177cardiac septum morphogenesis (GO:0060411)2.10143091
178cell proliferation involved in kidney development (GO:0072111)2.09640737
179lung secretory cell differentiation (GO:0061140)2.09541911
180auditory receptor cell differentiation (GO:0042491)2.08809306
181respiratory tube development (GO:0030323)2.08531516
182granulocyte activation (GO:0036230)2.08154531
183response to prostaglandin (GO:0034694)2.07977733
184regulation of mesenchymal cell proliferation (GO:0010464)2.07609947
185cellular response to prostaglandin stimulus (GO:0071379)2.07505659
186cardiac chamber morphogenesis (GO:0003206)2.07257753
187inner ear receptor cell differentiation (GO:0060113)2.06414048
188cell differentiation involved in kidney development (GO:0061005)2.06076705
189embryonic camera-type eye morphogenesis (GO:0048596)2.05847206
190positive regulation of mesenchymal cell proliferation (GO:0002053)2.04878089
191positive regulation of protein homooligomerization (GO:0032464)2.04136412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.18211044
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52972768
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97149539
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.87664751
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.74635381
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.54892483
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28431906
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27600732
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23796343
10TCF7_22412390_ChIP-Seq_EML_Mouse2.21235803
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13331134
12KDM2B_26808549_Chip-Seq_DND41_Human2.12568661
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12426068
14ZNF217_24962896_ChIP-Seq_MCF-7_Human2.07607477
15LXR_22292898_ChIP-Seq_THP-1_Human2.07250665
16MYC_22102868_ChIP-Seq_BL_Human2.03048949
17TP53_18474530_ChIP-ChIP_U2OS_Human2.02407027
18* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01901317
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97393266
20VDR_21846776_ChIP-Seq_THP-1_Human1.96835918
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.94538870
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.93252484
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.89271813
24SCL_19346495_ChIP-Seq_HPC-7_Human1.84937699
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84285712
26* KDM2B_26808549_Chip-Seq_K562_Human1.83177451
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80000507
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79973972
29RUNX_20019798_ChIP-Seq_JUKART_Human1.78066951
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76964374
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75528320
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.74228043
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72354178
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70255991
35* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69962024
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.68192637
37* VDR_24763502_ChIP-Seq_THP-1_Human1.65781842
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64482832
39AHR_22903824_ChIP-Seq_MCF-7_Human1.64414671
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.61992888
41MAF_26560356_Chip-Seq_TH1_Human1.60483789
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58954895
43* GATA1_19941827_ChIP-Seq_MEL_Mouse1.58155233
44SPI1_23127762_ChIP-Seq_K562_Human1.58048636
45EZH2_22144423_ChIP-Seq_EOC_Human1.57596442
46* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57564120
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56863193
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56306590
49CJUN_26792858_Chip-Seq_BT549_Human1.56033355
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.53778154
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.53574353
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53296133
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53216259
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52847544
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52731529
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52679033
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52476555
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52442101
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.52180440
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51904165
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51778248
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50638149
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50486341
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.49870246
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48122354
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48122354
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.47252207
68* TCF4_18268006_ChIP-ChIP_LS174T_Human1.45692830
69GATA1_19941826_ChIP-Seq_K562_Human1.45072017
70UTX_26944678_Chip-Seq_JUKART_Human1.44672616
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43809068
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43244369
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41329584
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.40885067
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39691103
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39605963
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.38656859
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38434036
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.37571542
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.37312374
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36991846
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.36572547
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36291336
84RNF2_27304074_Chip-Seq_NSC_Mouse1.36224860
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36166673
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36166673
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34983231
88FUS_26573619_Chip-Seq_HEK293_Human1.34293680
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33305123
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33175591
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32928559
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32325764
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31939711
94SOX2_20726797_ChIP-Seq_SW620_Human1.31822479
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.30891289
96* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28651785
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27421985
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27161608
99* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27072308
100* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26929304
101P300_19829295_ChIP-Seq_ESCs_Human1.26820741
102AR_21572438_ChIP-Seq_LNCaP_Human1.26790110
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.25882538
104IRF8_27001747_Chip-Seq_BMDM_Mouse1.25768299
105DROSHA_22980978_ChIP-Seq_HELA_Human1.25254958
106* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25084289
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24714178
108* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24281923
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23254949
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22638094
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22253547
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21806394
113* NANOG_18555785_Chip-Seq_ESCs_Mouse1.20752234
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19751642
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19593757
116EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19593757
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19358116
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.18410183
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17983448
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17968794
121* FLI1_27457419_Chip-Seq_LIVER_Mouse1.17788014
122* VDR_24787735_ChIP-Seq_THP-1_Human1.17335327
123GBX2_23144817_ChIP-Seq_PC3_Human1.17220865
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17138299
125RXR_22108803_ChIP-Seq_LS180_Human1.16586094
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16257251
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16193138
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15392333
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15338234
130BRD4_25478319_ChIP-Seq_HGPS_Human1.15303217
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.14426302
132MAF_26560356_Chip-Seq_TH2_Human1.14201276
133EWS_26573619_Chip-Seq_HEK293_Human1.13455571
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13211220
135* E2F1_18555785_Chip-Seq_ESCs_Mouse1.12834399
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12821132
137SA1_27219007_Chip-Seq_ERYTHROID_Human1.12744774
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12492467
139* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12173613
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11119451
141JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10742844
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.10389598
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10179373
144* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10007516
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09446925
146* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08673244
147P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08662615
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08643845
149SMC4_20622854_ChIP-Seq_HELA_Human1.08250909
150* P53_22387025_ChIP-Seq_ESCs_Mouse1.08077807
151GATA2_21666600_ChIP-Seq_HMVEC_Human1.07793804
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07653052
153GATA2_19941826_ChIP-Seq_K562_Human1.06796753
154GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06347537
155PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06334695
156* NFE2_27457419_Chip-Seq_LIVER_Mouse1.05433217
157DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04253257
158ER_23166858_ChIP-Seq_MCF-7_Human1.04198067
159IRF8_21731497_ChIP-ChIP_J774_Mouse1.04108288
160STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03903242
161SMAD3_21741376_ChIP-Seq_EPCs_Human1.03891563
162RUNX1_27514584_Chip-Seq_MCF-7_Human1.03357796
163RING1B_27294783_Chip-Seq_NPCs_Mouse1.02948681
164* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02683122
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01976207
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01976207
167* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01689784
168SALL1_21062744_ChIP-ChIP_HESCs_Human1.01474289
169FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01389452
170LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01052402
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00534488
172CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00530092
173* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00344440
174MYB_26560356_Chip-Seq_TH1_Human0.99902957
175NCOR1_26117541_ChIP-Seq_K562_Human0.98099448
176TP63_22573176_ChIP-Seq_HFKS_Human0.97101550
177PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96994428
178CREB1_26743006_Chip-Seq_LNCaP_Human0.95731851
179* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95487809
180CTCF_27219007_Chip-Seq_Bcells_Human0.95341964
181NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95217149
182LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92804451
183EGR1_19032775_ChIP-ChIP_M12_Human0.92317847
184* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91915110
185P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90241801
186* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89781421
187GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89778764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.96735699
2MP0005464_abnormal_platelet_physiology3.78896647
3MP0003303_peritoneal_inflammation3.50694323
4MP0003436_decreased_susceptibility_to3.32913877
5MP0001346_abnormal_lacrimal_gland3.27366594
6MP0008004_abnormal_stomach_pH3.15250835
7MP0003300_gastrointestinal_ulcer3.01097650
8MP0010234_abnormal_vibrissa_follicle2.84465621
9MP0003724_increased_susceptibility_to2.65671484
10MP0002877_abnormal_melanocyte_morpholog2.58814747
11MP0003941_abnormal_skin_development2.49911903
12MP0003787_abnormal_imprinting2.46417051
13MP0005623_abnormal_meninges_morphology2.32479083
14MP0008789_abnormal_olfactory_epithelium2.32249620
15MP0000566_synostosis2.24767908
16MP0002163_abnormal_gland_morphology2.23911232
17MP0009333_abnormal_splenocyte_physiolog2.22537071
18MP0004381_abnormal_hair_follicle2.22341460
19MP0005275_abnormal_skin_tensile2.18564180
20MP0005409_darkened_coat_color2.16644551
21MP0010030_abnormal_orbit_morphology2.14661980
22MP0004947_skin_inflammation2.14145969
23MP0005000_abnormal_immune_tolerance2.08076452
24MP0005083_abnormal_biliary_tract2.07285017
25MP0003705_abnormal_hypodermis_morpholog2.05433033
26MP0000465_gastrointestinal_hemorrhage2.03221727
27MP0000678_abnormal_parathyroid_gland1.99697195
28MP0010155_abnormal_intestine_physiology1.99582782
29MP0002166_altered_tumor_susceptibility1.97350005
30MP0001800_abnormal_humoral_immune1.96826793
31MP0009278_abnormal_bone_marrow1.90160870
32MP0004130_abnormal_muscle_cell1.89721569
33MP0003091_abnormal_cell_migration1.86113116
34MP0005499_abnormal_olfactory_system1.84604669
35MP0005394_taste/olfaction_phenotype1.84604669
36MP0001533_abnormal_skeleton_physiology1.77738563
37MP0005451_abnormal_body_composition1.75991567
38MP0002006_tumorigenesis1.74187096
39MP0002723_abnormal_immune_serum1.68792994
40MP0002419_abnormal_innate_immunity1.67217561
41MP0005171_absent_coat_pigmentation1.64900716
42MP0002452_abnormal_antigen_presenting1.64651731
43MP0004272_abnormal_basement_membrane1.64474100
44MP0002420_abnormal_adaptive_immunity1.63196480
45MP0002998_abnormal_bone_remodeling1.63129031
46MP0001819_abnormal_immune_cell1.62547667
47MP0000762_abnormal_tongue_morphology1.61250147
48MP0000858_altered_metastatic_potential1.60286504
49MP0005025_abnormal_response_to1.58817021
50MP0000537_abnormal_urethra_morphology1.56668373
51MP0003879_abnormal_hair_cell1.55220460
52MP0005248_abnormal_Harderian_gland1.54740345
53MP0001879_abnormal_lymphatic_vessel1.53704195
54MP0005058_abnormal_lysosome_morphology1.52981967
55MP0001851_eye_inflammation1.52880649
56MP0002249_abnormal_larynx_morphology1.52861836
57MP0005076_abnormal_cell_differentiation1.52705569
58MP0000049_abnormal_middle_ear1.52066882
59MP0003121_genomic_imprinting1.50431231
60MP0002098_abnormal_vibrissa_morphology1.50064926
61MP0001348_abnormal_lacrimal_gland1.47435898
62MP0005367_renal/urinary_system_phenotyp1.47363137
63MP0000516_abnormal_urinary_system1.47363137
64MP0003122_maternal_imprinting1.45730477
65MP0003385_abnormal_body_wall1.42805205
66MP0010678_abnormal_skin_adnexa1.42038704
67MP0002398_abnormal_bone_marrow1.39201111
68MP0005666_abnormal_adipose_tissue1.35879679
69MP0003866_abnormal_defecation1.34033035
70MP0000685_abnormal_immune_system1.32987718
71MP0004185_abnormal_adipocyte_glucose1.32902589
72MP0002282_abnormal_trachea_morphology1.31322538
73MP0009250_abnormal_appendicular_skeleto1.30059258
74MP0008260_abnormal_autophagy1.28821638
75MP0003942_abnormal_urinary_system1.28702975
76MP0000716_abnormal_immune_system1.26806943
77MP0002148_abnormal_hypersensitivity_rea1.26092079
78MP0000383_abnormal_hair_follicle1.26054143
79MP0005377_hearing/vestibular/ear_phenot1.25347725
80MP0003878_abnormal_ear_physiology1.25347725
81MP0009840_abnormal_foam_cell1.24637510
82MP0002233_abnormal_nose_morphology1.24481116
83MP0005023_abnormal_wound_healing1.21032883
84MP0003566_abnormal_cell_adhesion1.20913230
85MP0005375_adipose_tissue_phenotype1.20828075
86MP0000343_altered_response_to1.20311866
87MP0006292_abnormal_olfactory_placode1.16545252
88MP0005503_abnormal_tendon_morphology1.15653287
89MP0004510_myositis1.15462530
90MP0003937_abnormal_limbs/digits/tail_de1.13471129
91MP0000703_abnormal_thymus_morphology1.13177259
92MP0003183_abnormal_peptide_metabolism1.13018666
93MP0003755_abnormal_palate_morphology1.09916718
94MP0004264_abnormal_extraembryonic_tissu1.09778801
95MP0001188_hyperpigmentation1.09124386
96MP0004134_abnormal_chest_morphology1.06923818
97MP0001845_abnormal_inflammatory_respons1.06777874
98MP0006138_congestive_heart_failure1.06450781
99MP0001835_abnormal_antigen_presentation1.06273675
100MP0001849_ear_inflammation1.06132902
101MP0006082_CNS_inflammation1.05642446
102MP0000534_abnormal_ureter_morphology1.05049369
103MP0005310_abnormal_salivary_gland1.04743353
104MP0003279_aneurysm1.03301315
105MP0003448_altered_tumor_morphology1.02810947
106MP0002938_white_spotting1.02022453
107MP0000613_abnormal_salivary_gland1.01099760
108MP0002277_abnormal_respiratory_mucosa1.00478532
109MP0004858_abnormal_nervous_system1.00032684
110MP0000249_abnormal_blood_vessel0.99855002
111MP0002751_abnormal_autonomic_nervous0.99195072
112MP0005390_skeleton_phenotype0.99166500
113MP0002405_respiratory_system_inflammati0.99140177
114MP0002177_abnormal_outer_ear0.98875166
115MP0000767_abnormal_smooth_muscle0.98489471
116MP0002116_abnormal_craniofacial_bone0.98225980
117MP0001663_abnormal_digestive_system0.98108766
118MP0000428_abnormal_craniofacial_morphol0.97901525
119MP0002089_abnormal_postnatal_growth/wei0.97873229
120MP0002429_abnormal_blood_cell0.97422945
121MP0002722_abnormal_immune_system0.97312466
122MP0001286_abnormal_eye_development0.97135450
123MP0003567_abnormal_fetal_cardiomyocyte0.96695075
124MP0008874_decreased_physiological_sensi0.94246939
125MP0005501_abnormal_skin_physiology0.93568995
126MP0005508_abnormal_skeleton_morphology0.92594714
127MP0003045_fibrosis0.91962732
128MP0003763_abnormal_thymus_physiology0.91598559
129MP0003935_abnormal_craniofacial_develop0.89366980
130MP0002138_abnormal_hepatobiliary_system0.88438916
131MP0002060_abnormal_skin_morphology0.87883288
132MP0010386_abnormal_urinary_bladder0.86617151
133MP0000163_abnormal_cartilage_morphology0.86124622
134MP0009785_altered_susceptibility_to0.85965438
135MP0005166_decreased_susceptibility_to0.84932651
136MP0000681_abnormal_thyroid_gland0.84586042
137MP0004036_abnormal_muscle_relaxation0.83979793
138MP0008438_abnormal_cutaneous_collagen0.83351255
139MP0003943_abnormal_hepatobiliary_system0.83284669
140MP0005387_immune_system_phenotype0.82892707
141MP0001790_abnormal_immune_system0.82892707
142MP0005379_endocrine/exocrine_gland_phen0.81278933
143MP0000689_abnormal_spleen_morphology0.80959934
144MP0003828_pulmonary_edema0.80765120
145MP0005671_abnormal_response_to0.80415748
146MP0003638_abnormal_response/metabolism_0.80337660
147MP0005381_digestive/alimentary_phenotyp0.79889008
148MP0003646_muscle_fatigue0.79693383
149MP0001919_abnormal_reproductive_system0.79389058
150MP0000627_abnormal_mammary_gland0.78290491
151MP0002932_abnormal_joint_morphology0.78126922
152MP0002796_impaired_skin_barrier0.77605657
153MP0003453_abnormal_keratinocyte_physiol0.77181416
154MP0000432_abnormal_head_morphology0.76706003
155MP0000538_abnormal_urinary_bladder0.76252616
156MP0002109_abnormal_limb_morphology0.75708262
157MP0009764_decreased_sensitivity_to0.75621384
158MP0009780_abnormal_chondrocyte_physiolo0.75499175
159MP0000778_abnormal_nervous_system0.75466362
160MP0004808_abnormal_hematopoietic_stem0.74473783
161MP0001873_stomach_inflammation0.74059537
162MP0000026_abnormal_inner_ear0.73683094
163MP0005257_abnormal_intraocular_pressure0.73307547
164MP0000490_abnormal_crypts_of0.73297508
165MP0000579_abnormal_nail_morphology0.71194792
166MP0008569_lethality_at_weaning0.71145899
167MP0002933_joint_inflammation0.69847491
168MP0003119_abnormal_digestive_system0.68464470
169MP0002971_abnormal_brown_adipose0.68334996
170MP0000015_abnormal_ear_pigmentation0.68324849
171MP0000003_abnormal_adipose_tissue0.67911453
172MP0004084_abnormal_cardiac_muscle0.67760687
173MP0002254_reproductive_system_inflammat0.67242982
174MP0003075_altered_response_to0.66788239
175MP0001216_abnormal_epidermal_layer0.64980340
176MP0004782_abnormal_surfactant_physiolog0.63845363
177MP0003115_abnormal_respiratory_system0.63602548

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.15292358
2Abnormal platelet volume (HP:0011876)4.51718611
3Increased mean platelet volume (HP:0011877)4.43873995
4Purpura (HP:0000979)4.36572719
5Menorrhagia (HP:0000132)4.29107599
6Epistaxis (HP:0000421)3.69454260
7Petechiae (HP:0000967)3.68241513
8Spontaneous hematomas (HP:0007420)3.52840643
9Eczematoid dermatitis (HP:0000976)3.48271568
10Lip pit (HP:0100267)3.31345131
11Gingival bleeding (HP:0000225)3.14375072
12Stomach cancer (HP:0012126)3.13796250
13Papillary thyroid carcinoma (HP:0002895)3.13779898
14Increased IgM level (HP:0003496)2.97489707
15Onycholysis (HP:0001806)2.86794213
16Obstructive sleep apnea (HP:0002870)2.80146331
17Right ventricular cardiomyopathy (HP:0011663)2.74520886
18Recurrent bacterial skin infections (HP:0005406)2.70918873
19Abnormality of macrophages (HP:0004311)2.70386237
20Occipital encephalocele (HP:0002085)2.58718984
2111 pairs of ribs (HP:0000878)2.55261447
22Impaired platelet aggregation (HP:0003540)2.50655515
23Abnormal platelet function (HP:0011869)2.50655515
24Alveolar cell carcinoma (HP:0006519)2.49945597
25Gastrointestinal infarctions (HP:0005244)2.46060971
26Abnormality of skeletal muscle fiber size (HP:0012084)2.44797317
27Increased variability in muscle fiber diameter (HP:0003557)2.43865285
28True hermaphroditism (HP:0010459)2.41382459
29Humeroradial synostosis (HP:0003041)2.37519648
30Synostosis involving the elbow (HP:0003938)2.37519648
31Asymmetry of the thorax (HP:0001555)2.35814544
32Hypercortisolism (HP:0001578)2.35350368
33Abnormal hair whorl (HP:0010721)2.34559502
34Atrophic scars (HP:0001075)2.34144015
35Pulmonary artery stenosis (HP:0004415)2.33189758
36Recurrent abscess formation (HP:0002722)2.31505145
37Eosinophilia (HP:0001880)2.31366119
38Optic neuritis (HP:0100653)2.30770530
39Retrobulbar optic neuritis (HP:0100654)2.30770530
40Subacute progressive viral hepatitis (HP:0006572)2.29617865
41Muscle fiber splitting (HP:0003555)2.27273311
42Curly hair (HP:0002212)2.21000310
43Thyroid carcinoma (HP:0002890)2.20948462
44Increased IgE level (HP:0003212)2.20919113
45Germ cell neoplasia (HP:0100728)2.18233694
46Peritonitis (HP:0002586)2.17511464
47Bilateral sensorineural hearing impairment (HP:0008619)2.16416664
48Stomatitis (HP:0010280)2.16080712
49Neonatal short-limb short stature (HP:0008921)2.15748030
50Abnormality of the nasal septum (HP:0000419)2.15421319
51Absent eyebrow (HP:0002223)2.15043290
52Obstructive lung disease (HP:0006536)2.14209118
53Chronic obstructive pulmonary disease (HP:0006510)2.14209118
54Elevated erythrocyte sedimentation rate (HP:0003565)2.13756153
55Neoplasm of the tracheobronchial system (HP:0100552)2.10872683
56Distal lower limb amyotrophy (HP:0008944)2.10859993
57Micronodular cirrhosis (HP:0001413)2.10624717
58Vasculitis (HP:0002633)2.10614294
59Exercise-induced myalgia (HP:0003738)2.10510698
60Difficulty running (HP:0009046)2.09049500
61Hyperlipoproteinemia (HP:0010980)2.08270537
62Morphological abnormality of the middle ear (HP:0008609)2.06550668
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.06036655
64Milia (HP:0001056)2.05371244
65Distal lower limb muscle weakness (HP:0009053)2.01713274
66Popliteal pterygium (HP:0009756)2.01267852
67Cutaneous finger syndactyly (HP:0010554)2.00621446
68Hepatoblastoma (HP:0002884)1.99737273
69Chest pain (HP:0100749)1.99313476
70Cellulitis (HP:0100658)1.96582590
71Renal tubular acidosis (HP:0001947)1.96205707
72Gastrointestinal inflammation (HP:0004386)1.93579021
73Sprengel anomaly (HP:0000912)1.93328300
74Abnormality of the gastric mucosa (HP:0004295)1.93110680
75Palpebral edema (HP:0100540)1.92817014
76Peripheral hypomyelination (HP:0007182)1.92606753
77Prostate neoplasm (HP:0100787)1.92190309
78Colitis (HP:0002583)1.92073267
79Heterochromia iridis (HP:0001100)1.91945396
80Sparse scalp hair (HP:0002209)1.90495424
81Orchitis (HP:0100796)1.90019103
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.89426953
83Aplasia cutis congenita (HP:0001057)1.89342190
84Hyporeflexia of lower limbs (HP:0002600)1.89057729
85Inflammation of the large intestine (HP:0002037)1.87753683
86Bruising susceptibility (HP:0000978)1.87279624
87Periauricular skin pits (HP:0100277)1.86463168
88Preauricular pit (HP:0004467)1.86463168
89Cutaneous syndactyly (HP:0012725)1.85074941
90Abnormal pancreas size (HP:0012094)1.84716813
91Meningitis (HP:0001287)1.84008293
92Gingivitis (HP:0000230)1.82321611
93Ventricular fibrillation (HP:0001663)1.82293730
94Mediastinal lymphadenopathy (HP:0100721)1.82252980
95Easy fatigability (HP:0003388)1.81722484
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81481652
97Thin bony cortex (HP:0002753)1.79711848
98Increased connective tissue (HP:0009025)1.79531995
99Arterial thrombosis (HP:0004420)1.79492289
100Progressive sensorineural hearing impairment (HP:0000408)1.77391169
101Hip dysplasia (HP:0001385)1.76963509
102Increased density of long bones (HP:0006392)1.76221292
103Onion bulb formation (HP:0003383)1.76018414
104Amyloidosis (HP:0011034)1.75262537
105Nasal polyposis (HP:0100582)1.75157735
106Abnormality of incisor morphology (HP:0011063)1.75155387
107Malnutrition (HP:0004395)1.75002210
108Gastrointestinal stroma tumor (HP:0100723)1.73201445
109Natal tooth (HP:0000695)1.72785480
110Cerebral aneurysm (HP:0004944)1.72062579
111Deep philtrum (HP:0002002)1.71577244
112Abnormality of the nasolacrimal system (HP:0000614)1.71181120
113Fragile nails (HP:0001808)1.70409012
114Bulbar palsy (HP:0001283)1.69251271
115Long palpebral fissure (HP:0000637)1.69165902
116Ulnar deviation of the wrist (HP:0003049)1.68802300
117Pustule (HP:0200039)1.68287370
118Pulmonary embolism (HP:0002204)1.67843383
119Deep palmar crease (HP:0006191)1.67730264
120Neoplasm of the adrenal cortex (HP:0100641)1.67433573
121Abnormality of the nasal mucosa (HP:0000433)1.67090890
122Syringomyelia (HP:0003396)1.66687540
123Spinal cord lesions (HP:0100561)1.66687540
124Hypoplasia of the iris (HP:0007676)1.66646440
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.66111587
126Renal dysplasia (HP:0000110)1.64274452
127Abnormality of the lacrimal duct (HP:0011481)1.64108575
128Abnormal sex determination (HP:0012244)1.63498881
129Sex reversal (HP:0012245)1.63498881
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63055955
131Abnormality of the fingertips (HP:0001211)1.62815692
132Encephalitis (HP:0002383)1.61273397
133Granulocytopenia (HP:0001913)1.60209347
134Abnormality of T cell number (HP:0011839)1.59753831
135Hemorrhage of the eye (HP:0011885)1.59370376
136Bronchomalacia (HP:0002780)1.58691721
137Myopathic facies (HP:0002058)1.58483669
138Cerebral inclusion bodies (HP:0100314)1.58429702
139Neonatal hypoglycemia (HP:0001998)1.58233355
140Long nose (HP:0003189)1.58146095
141Aortic aneurysm (HP:0004942)1.57945710
142Genu recurvatum (HP:0002816)1.57657479
143Recurrent gram-negative bacterial infections (HP:0005420)1.57554300
144Abnormality of eosinophils (HP:0001879)1.56957336
145Gangrene (HP:0100758)1.56643406
146Mesomelia (HP:0003027)1.55778285
147Thick nail (HP:0001805)1.55402000
148Emphysema (HP:0002097)1.55046604
149Fibular hypoplasia (HP:0003038)1.55009450
150Segmental peripheral demyelination/remyelination (HP:0003481)1.54850447
151Neurofibrillary tangles (HP:0002185)1.54808896
152Flat acetabular roof (HP:0003180)1.54715576
153Skin pits (HP:0100276)1.54178020
154Episodic fever (HP:0001954)1.53920785
155Optic nerve coloboma (HP:0000588)1.53764623
156Aplasia/Hypoplasia of the scapulae (HP:0006713)1.53762874
157Hypoplastic scapulae (HP:0000882)1.53762874
158Abnormality of the humeroradial joint (HP:0100744)1.53717968
159Keratoconjunctivitis sicca (HP:0001097)1.53655907
160Abnormality of the right ventricle (HP:0001707)1.53573434
161Missing ribs (HP:0000921)1.53115573
162Osteomalacia (HP:0002749)1.52973394
163T lymphocytopenia (HP:0005403)1.52787841
164Thoracic kyphosis (HP:0002942)1.52748297
165Neoplasm of the lung (HP:0100526)1.52129079
166Myositis (HP:0100614)1.51764025
167Hypothermia (HP:0002045)1.51032596
168Thickened helices (HP:0000391)1.50167052
169Pulmonary infiltrates (HP:0002113)1.49957560
170Renal hypoplasia (HP:0000089)1.49703997
171Short hallux (HP:0010109)1.49660983
172Ridged nail (HP:0001807)1.49558621
173Nephroblastoma (Wilms tumor) (HP:0002667)1.48586326
174Polygenic inheritance (HP:0010982)1.48335143
175Dilatation of the ascending aorta (HP:0005111)1.48054086
176Keratoconjunctivitis (HP:0001096)1.48038910
177Advanced eruption of teeth (HP:0006288)1.47949450
178Scapular winging (HP:0003691)1.47702553
179Overgrowth (HP:0001548)1.47471442
180Metaphyseal cupping (HP:0003021)1.47241318
181Type 1 muscle fiber predominance (HP:0003803)1.47112082
182Woolly hair (HP:0002224)1.45877291
183Absent eyelashes (HP:0000561)1.45824460
184Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.45406098
185Hypergammaglobulinemia (HP:0010702)1.45276303
186Vertebral hypoplasia (HP:0008417)1.44139425
187Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.44139425
188Autoimmune hemolytic anemia (HP:0001890)1.43095192
189Tarsal synostosis (HP:0008368)1.42790523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK16.39793650
2MAP3K143.93546524
3ZAK3.92847569
4BCR3.64579943
5MAP4K13.19902213
6BMPR23.16031060
7ERBB33.12639139
8CASK3.01107701
9RIPK42.88490808
10TRIB32.83722442
11MST42.62152417
12STK242.55019475
13NUAK12.47392732
14FRK2.46184187
15FER2.18446282
16ERN12.10883507
17CHUK2.09472065
18SIK32.05544748
19BMPR1B1.93273436
20AKT31.76057063
21YES11.75986514
22TRPM71.73399262
23MAP3K101.72427326
24CSK1.71047991
25STK38L1.61336807
26EPHB21.59357006
27IKBKB1.58953104
28SIK11.58691068
29PDPK11.54288999
30MARK21.52331210
31EPHA31.51345769
32PLK21.48160549
33PTK61.47032767
34PIK3CA1.45198315
35ZAP701.43350191
36TYRO31.42254339
37TXK1.39402016
38SGK21.38654562
39SMG11.37830062
40BMX1.37136691
41CDK121.34473043
42MYLK1.34315158
43BTK1.30130889
44EPHA21.28377046
45MKNK21.26433249
46RPS6KC11.22053433
47RPS6KL11.22053433
48FGR1.21899469
49TAOK11.20573403
50IRAK31.20399389
51FGFR41.19287847
52NLK1.18990430
53RPS6KA21.18496649
54PIM21.17996508
55RPS6KA61.17650663
56CDC42BPA1.16808217
57MKNK11.16442512
58MAP2K31.13556832
59NME11.12527388
60STK381.11816112
61ICK1.10809955
62GRK61.06263164
63TESK11.05944082
64INSRR1.05205872
65BLK1.04859069
66KSR21.04602962
67LATS21.04510570
68MAP3K11.04419493
69STK31.04374687
70TTN1.04043524
71ARAF1.02998283
72PRKCE1.01555440
73SYK1.01542910
74JAK31.00606461
75HCK0.97583855
76EPHB10.96692307
77PRPF4B0.93707362
78SGK30.92703387
79FES0.92375417
80CAMKK10.90624093
81CLK10.90466336
82DMPK0.87637883
83PKN10.86337453
84ROCK10.84983382
85MAPK120.83443951
86TAOK20.82413039
87SIK20.81795174
88MAP3K110.80323084
89HIPK20.79851255
90PIM10.78583411
91MAP3K70.78506068
92IKBKE0.77630439
93EIF2AK20.76743986
94MOS0.76505523
95IRAK20.74736668
96CSF1R0.73924710
97LATS10.73773681
98MAPK130.73495154
99DDR20.72118370
100LRRK20.71022315
101PRKD20.70463104
102CAMK1D0.70336882
103MAP3K90.69624669
104MARK30.68870357
105PDK10.67993700
106IRAK40.67913488
107PAK30.67879745
108SGK2230.65481279
109SGK4940.65481279
110IRAK10.65024967
111SRPK10.64980742
112LCK0.63163867
113ITK0.63100220
114EEF2K0.62833741
115MAPKAPK20.61824373
116TBK10.61383481
117CAMK1G0.60006797
118PKN20.59719193
119MTOR0.59659939
120MAP3K30.59008279
121DAPK30.56706276
122RET0.55915835
123FYN0.55886655
124MST1R0.55790760
125RPS6KB20.54901589
126JAK10.53898316
127TEC0.53572703
128MAP3K20.53518960
129MAP2K70.51404489
130DYRK1B0.51170621
131MATK0.50499082
132LYN0.49713064
133PTK2B0.49556299
134PTK20.48454585
135FGFR30.47827427
136NEK60.47677578
137MAPK70.46501878
138MAPK150.45553332
139MAP2K10.44761876
140GSK3A0.44622085
141PRKCQ0.44432935
142PDGFRB0.44238260
143SGK10.42680028
144LIMK10.40250920
145RPS6KA10.40194928
146MAP3K130.39755705
147NEK90.39362219
148RPS6KB10.37780065
149PRKCI0.36414723
150PDGFRA0.36216670
151ILK0.35936959
152AKT10.34763717
153MAP2K20.34632137
154CDK30.34494883
155MAPK30.33685055
156MUSK0.33208962
157TNK20.33038989
158STK40.29801061
159MAP3K120.29371169
160RPS6KA50.28961681
161TYK20.28789723
162INSR0.27947925
163PRKG20.27801405

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.55447195
2Autoimmune thyroid disease_Homo sapiens_hsa053202.06555969
3Graft-versus-host disease_Homo sapiens_hsa053322.04850098
4Platelet activation_Homo sapiens_hsa046111.88976769
5B cell receptor signaling pathway_Homo sapiens_hsa046621.88872959
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.82104087
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73318396
8Adherens junction_Homo sapiens_hsa045201.60530881
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53007983
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50251455
11Viral myocarditis_Homo sapiens_hsa054161.41698520
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41329375
13Basal cell carcinoma_Homo sapiens_hsa052171.38645192
14VEGF signaling pathway_Homo sapiens_hsa043701.38203177
15TNF signaling pathway_Homo sapiens_hsa046681.34414176
16Type I diabetes mellitus_Homo sapiens_hsa049401.30476829
17Hippo signaling pathway_Homo sapiens_hsa043901.29546740
18Toxoplasmosis_Homo sapiens_hsa051451.28645987
19Measles_Homo sapiens_hsa051621.28507671
20Rheumatoid arthritis_Homo sapiens_hsa053231.27145339
21Phospholipase D signaling pathway_Homo sapiens_hsa040721.26709253
22Endometrial cancer_Homo sapiens_hsa052131.24293027
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.23081154
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22884537
25Small cell lung cancer_Homo sapiens_hsa052221.19039977
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14158010
27Choline metabolism in cancer_Homo sapiens_hsa052311.13443418
28Renal cell carcinoma_Homo sapiens_hsa052111.12924746
29Leishmaniasis_Homo sapiens_hsa051401.12541594
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11893519
31Prostate cancer_Homo sapiens_hsa052151.10875731
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10631189
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09100482
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07853538
35Tight junction_Homo sapiens_hsa045301.06519010
36ECM-receptor interaction_Homo sapiens_hsa045121.06292275
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.06026970
38Proteoglycans in cancer_Homo sapiens_hsa052051.05718242
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.05411211
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05154068
41MicroRNAs in cancer_Homo sapiens_hsa052061.05054840
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04600489
43Focal adhesion_Homo sapiens_hsa045101.03832225
44* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03418707
45Influenza A_Homo sapiens_hsa051641.03037431
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02467309
47mTOR signaling pathway_Homo sapiens_hsa041501.02272410
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02003713
49Prolactin signaling pathway_Homo sapiens_hsa049171.01486861
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01071522
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00899328
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00850473
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00835592
54Sulfur metabolism_Homo sapiens_hsa009200.98628685
55Thyroid cancer_Homo sapiens_hsa052160.98361063
56Tuberculosis_Homo sapiens_hsa051520.97660269
57TGF-beta signaling pathway_Homo sapiens_hsa043500.97200318
58HTLV-I infection_Homo sapiens_hsa051660.94916215
59Melanoma_Homo sapiens_hsa052180.93790005
60Notch signaling pathway_Homo sapiens_hsa043300.93750410
61Colorectal cancer_Homo sapiens_hsa052100.92472376
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91535768
63Insulin signaling pathway_Homo sapiens_hsa049100.90918201
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90678173
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90392565
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90287929
67Long-term potentiation_Homo sapiens_hsa047200.89974807
68Gap junction_Homo sapiens_hsa045400.89269268
69Pathways in cancer_Homo sapiens_hsa052000.88953914
70Dilated cardiomyopathy_Homo sapiens_hsa054140.88831018
71Herpes simplex infection_Homo sapiens_hsa051680.88220342
72Chronic myeloid leukemia_Homo sapiens_hsa052200.88042928
73Primary immunodeficiency_Homo sapiens_hsa053400.87939108
74GnRH signaling pathway_Homo sapiens_hsa049120.87878148
75Wnt signaling pathway_Homo sapiens_hsa043100.86708549
76Hedgehog signaling pathway_Homo sapiens_hsa043400.86141246
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85873827
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.85270466
79Asthma_Homo sapiens_hsa053100.84916089
80Apoptosis_Homo sapiens_hsa042100.83725928
81Chemokine signaling pathway_Homo sapiens_hsa040620.83676154
82Hepatitis B_Homo sapiens_hsa051610.83462827
83Melanogenesis_Homo sapiens_hsa049160.82318370
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81894374
85* T cell receptor signaling pathway_Homo sapiens_hsa046600.81234040
86Pancreatic cancer_Homo sapiens_hsa052120.80942619
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80702704
88Insulin resistance_Homo sapiens_hsa049310.80625881
89Shigellosis_Homo sapiens_hsa051310.80070529
90Endocytosis_Homo sapiens_hsa041440.79832127
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79798332
92Staphylococcus aureus infection_Homo sapiens_hsa051500.79320155
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.79164824
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.79024184
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78665752
96Acute myeloid leukemia_Homo sapiens_hsa052210.78044475
97Antigen processing and presentation_Homo sapiens_hsa046120.78038864
98* Axon guidance_Homo sapiens_hsa043600.77665956
99Estrogen signaling pathway_Homo sapiens_hsa049150.77503109
100African trypanosomiasis_Homo sapiens_hsa051430.77194503
101Salmonella infection_Homo sapiens_hsa051320.76642879
102HIF-1 signaling pathway_Homo sapiens_hsa040660.75815178
103Osteoclast differentiation_Homo sapiens_hsa043800.74274991
104FoxO signaling pathway_Homo sapiens_hsa040680.73701324
105Amoebiasis_Homo sapiens_hsa051460.73370992
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72953896
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.71336347
108Collecting duct acid secretion_Homo sapiens_hsa049660.70981261
109Hepatitis C_Homo sapiens_hsa051600.70557460
110Pertussis_Homo sapiens_hsa051330.69932036
111Protein export_Homo sapiens_hsa030600.69766522
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68953065
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68843986
114p53 signaling pathway_Homo sapiens_hsa041150.67660132
115Non-homologous end-joining_Homo sapiens_hsa034500.66700700
116Dorso-ventral axis formation_Homo sapiens_hsa043200.65815062
117Vibrio cholerae infection_Homo sapiens_hsa051100.65464017
118Legionellosis_Homo sapiens_hsa051340.64137116
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64121918
120Inositol phosphate metabolism_Homo sapiens_hsa005620.61819026
121Rap1 signaling pathway_Homo sapiens_hsa040150.61716503
122Hematopoietic cell lineage_Homo sapiens_hsa046400.61362272
123Malaria_Homo sapiens_hsa051440.58957351
124Prion diseases_Homo sapiens_hsa050200.57734918
125Oxytocin signaling pathway_Homo sapiens_hsa049210.57609054
126* ErbB signaling pathway_Homo sapiens_hsa040120.57188808
127Pancreatic secretion_Homo sapiens_hsa049720.56130404
128MAPK signaling pathway_Homo sapiens_hsa040100.55663345
129Type II diabetes mellitus_Homo sapiens_hsa049300.55599083
130Viral carcinogenesis_Homo sapiens_hsa052030.55027168
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54692193
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54620805
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53728331
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51951986
135Ras signaling pathway_Homo sapiens_hsa040140.51899142
136Glioma_Homo sapiens_hsa052140.51312583
137Epstein-Barr virus infection_Homo sapiens_hsa051690.51279673
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49531360
139Non-small cell lung cancer_Homo sapiens_hsa052230.49014842

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