NCKIPSD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25935352
2synaptic vesicle maturation (GO:0016188)5.92320363
3synaptic vesicle exocytosis (GO:0016079)5.62006971
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38634153
5locomotory exploration behavior (GO:0035641)5.33551422
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30773052
7glutamate secretion (GO:0014047)5.28400434
8vocalization behavior (GO:0071625)5.18281874
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14835425
10regulation of glutamate receptor signaling pathway (GO:1900449)4.94793990
11regulation of synaptic vesicle exocytosis (GO:2000300)4.91201772
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.79930992
13neuronal action potential propagation (GO:0019227)4.79536189
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.75902981
15regulation of synaptic vesicle transport (GO:1902803)4.61745037
16protein localization to synapse (GO:0035418)4.57651114
17neurotransmitter secretion (GO:0007269)4.47253006
18neuron cell-cell adhesion (GO:0007158)4.46578794
19regulation of neuronal synaptic plasticity (GO:0048168)4.35897802
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32111243
21synaptic transmission, glutamatergic (GO:0035249)4.30858134
22exploration behavior (GO:0035640)4.26154830
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.23438990
24cytoskeletal anchoring at plasma membrane (GO:0007016)4.18930194
25glutamate receptor signaling pathway (GO:0007215)4.11589969
26regulation of synapse structural plasticity (GO:0051823)4.09599394
27neuron-neuron synaptic transmission (GO:0007270)4.09278010
28neurotransmitter-gated ion channel clustering (GO:0072578)4.01354927
29long-term memory (GO:0007616)3.96819587
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79061403
31transmission of nerve impulse (GO:0019226)3.77533720
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76358795
33synaptic vesicle endocytosis (GO:0048488)3.68669725
34neurotransmitter transport (GO:0006836)3.68472776
35gamma-aminobutyric acid transport (GO:0015812)3.68297051
36cellular potassium ion homeostasis (GO:0030007)3.67715015
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63709494
38positive regulation of membrane potential (GO:0045838)3.62794025
39proline transport (GO:0015824)3.60662839
40long-term synaptic potentiation (GO:0060291)3.54384323
41regulation of synaptic plasticity (GO:0048167)3.53521699
42glycine transport (GO:0015816)3.51012253
43regulation of early endosome to late endosome transport (GO:2000641)3.49983227
44positive regulation of synapse maturation (GO:0090129)3.48959876
45amino acid import (GO:0043090)3.47445308
46layer formation in cerebral cortex (GO:0021819)3.46081286
47regulation of postsynaptic membrane potential (GO:0060078)3.44844582
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.44741226
49neuron recognition (GO:0008038)3.44566150
50neuromuscular process controlling posture (GO:0050884)3.40531460
51regulation of neurotransmitter secretion (GO:0046928)3.39073646
52regulation of ARF protein signal transduction (GO:0032012)3.38834837
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38751665
54proline biosynthetic process (GO:0006561)3.37922536
55regulation of neurotransmitter levels (GO:0001505)3.37894682
56regulation of vesicle fusion (GO:0031338)3.36134786
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34329396
58cerebellar Purkinje cell differentiation (GO:0021702)3.33333109
59protein retention in ER lumen (GO:0006621)3.32360222
60adult walking behavior (GO:0007628)3.31927831
61postsynaptic membrane organization (GO:0001941)3.31567555
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30934465
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.27849452
64axonal fasciculation (GO:0007413)3.25815078
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25139105
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22822756
67protein maturation by protein folding (GO:0022417)3.19010666
68regulation of mammary gland epithelial cell proliferation (GO:0033599)3.16160734
69membrane depolarization (GO:0051899)3.15257073
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15033729
71membrane depolarization during action potential (GO:0086010)3.14055394
72potassium ion homeostasis (GO:0055075)3.13712499
73neuromuscular process controlling balance (GO:0050885)3.13588482
74cellular sodium ion homeostasis (GO:0006883)3.12662708
75presynaptic membrane assembly (GO:0097105)3.12607276
76regulation of neurotransmitter transport (GO:0051588)3.12597546
77regulation of dendritic spine morphogenesis (GO:0061001)3.11299130
78regulation of voltage-gated calcium channel activity (GO:1901385)3.10396681
79cell-cell junction maintenance (GO:0045217)3.10313047
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09831423
81sodium ion export (GO:0071436)3.08848812
82negative regulation of microtubule polymerization (GO:0031115)3.08705138
83membrane hyperpolarization (GO:0060081)3.08072678
84dendritic spine morphogenesis (GO:0060997)3.08071368
85negative regulation of dendrite morphogenesis (GO:0050774)3.07430514
86cerebellar Purkinje cell layer development (GO:0021680)3.05636152
87activation of protein kinase A activity (GO:0034199)3.05268889
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05164373
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05098711
90protein localization to endosome (GO:0036010)3.01902574
91regulation of synapse maturation (GO:0090128)3.01724965
92positive regulation of synaptic transmission (GO:0050806)3.01346329
93vesicle transport along microtubule (GO:0047496)3.01326435
94regulation of synaptic transmission (GO:0050804)3.01177819
95L-amino acid import (GO:0043092)3.00512645
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00300219
97presynaptic membrane organization (GO:0097090)3.00060261
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98628479
99positive regulation of neurotransmitter secretion (GO:0001956)2.97748684
100negative regulation of amino acid transport (GO:0051956)2.97431846
101mating behavior (GO:0007617)2.96589423
102synaptic transmission (GO:0007268)2.95906715
103behavioral fear response (GO:0001662)2.95854269
104behavioral defense response (GO:0002209)2.95854269
105neuronal ion channel clustering (GO:0045161)2.95786800
106positive regulation of dendritic spine development (GO:0060999)2.95576550
107cell migration in hindbrain (GO:0021535)2.95173314
108learning (GO:0007612)2.95068450
109adherens junction assembly (GO:0034333)2.94496216
110positive regulation of neurotransmitter transport (GO:0051590)2.93401300
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92524147
112regulation of glutamate secretion (GO:0014048)2.91388904
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89950955
114response to histamine (GO:0034776)2.89465284
115cell communication by electrical coupling (GO:0010644)2.88355776
116innervation (GO:0060384)2.87520488
117establishment of synaptic vesicle localization (GO:0097480)2.86426054
118synaptic vesicle transport (GO:0048489)2.86426054
119COPI coating of Golgi vesicle (GO:0048205)2.82530373
120Golgi transport vesicle coating (GO:0048200)2.82530373
121cerebellar granule cell differentiation (GO:0021707)2.81967019
122activation of Rac GTPase activity (GO:0032863)2.81585400
123proline metabolic process (GO:0006560)2.78486632
124myelination in peripheral nervous system (GO:0022011)2.70892378
125peripheral nervous system axon ensheathment (GO:0032292)2.70892378
126regulation of cholesterol biosynthetic process (GO:0045540)2.66528616
127heterochromatin organization (GO:0070828)2.65508280
128glycolytic process (GO:0006096)2.65289729
129adenosine receptor signaling pathway (GO:0001973)2.64413002
130axon ensheathment in central nervous system (GO:0032291)2.63186947
131central nervous system myelination (GO:0022010)2.63186947
132cell-substrate adherens junction assembly (GO:0007045)2.61362289
133focal adhesion assembly (GO:0048041)2.61362289
134protein targeting to plasma membrane (GO:0072661)2.59938018
135gluconeogenesis (GO:0006094)2.57091960
136positive regulation of protein dephosphorylation (GO:0035307)2.57004342
137positive regulation of dendritic spine morphogenesis (GO:0061003)2.55897032
138positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54641174
139vesicle docking involved in exocytosis (GO:0006904)2.54640186
140activation of MAPKKK activity (GO:0000185)2.53513922
141negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.51332585
142glucose 6-phosphate metabolic process (GO:0051156)2.50654292
143establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49424511
144mitochondrion transport along microtubule (GO:0047497)2.49424511
145myelin maintenance (GO:0043217)2.48598854
146establishment of mitochondrion localization (GO:0051654)2.48571770
147regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.47703392
148dendritic spine organization (GO:0097061)2.47529841
149mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.43217465
150dopamine receptor signaling pathway (GO:0007212)2.43102649
151cellular protein complex localization (GO:0034629)2.42442580
152protein insertion into membrane (GO:0051205)2.41665179
153dicarboxylic acid transport (GO:0006835)2.38884287
154cellular component maintenance (GO:0043954)2.35872869
155regulation of NFAT protein import into nucleus (GO:0051532)2.34735216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.64523119
2GBX2_23144817_ChIP-Seq_PC3_Human3.45963140
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26872706
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12535021
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11486506
6IKZF1_21737484_ChIP-ChIP_HCT116_Human3.02134514
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85961077
8REST_21632747_ChIP-Seq_MESCs_Mouse2.85856363
9* LXR_22292898_ChIP-Seq_THP-1_Human2.83021762
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80917400
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80917400
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76568261
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.74433784
14DROSHA_22980978_ChIP-Seq_HELA_Human2.68696125
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64787702
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62344779
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59702175
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58961462
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.43519082
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.36656412
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36528808
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35948786
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.35388507
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35360471
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.31037359
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24464524
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.14028752
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12100396
29SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05670256
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05535329
31RACK7_27058665_Chip-Seq_MCF-7_Human1.95434635
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.92030876
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88787268
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.84263756
35ZNF263_19887448_ChIP-Seq_K562_Human1.82439856
36P68_20966046_ChIP-Seq_HELA_Human1.82044724
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81606507
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80919476
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75586959
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.75579767
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74548865
42KDM2B_26808549_Chip-Seq_DND41_Human1.72168968
43E2F7_22180533_ChIP-Seq_HELA_Human1.71183912
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69700654
45* TET1_21451524_ChIP-Seq_MESCs_Mouse1.64967311
46AR_21572438_ChIP-Seq_LNCaP_Human1.63975277
47MYC_22102868_ChIP-Seq_BL_Human1.63951246
48VDR_21846776_ChIP-Seq_THP-1_Human1.63454212
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.63270824
50SMC4_20622854_ChIP-Seq_HELA_Human1.57848149
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56065555
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55733135
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54561537
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51003191
55SMAD4_21799915_ChIP-Seq_A2780_Human1.49320675
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47324032
57CREB1_26743006_Chip-Seq_LNCaP_Human1.46289390
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45835086
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.43837773
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43822613
61TCF7_22412390_ChIP-Seq_EML_Mouse1.43332909
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43035142
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42427959
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42165969
65* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40757715
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40663537
67IGF1R_20145208_ChIP-Seq_DFB_Human1.39750217
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39611296
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38961578
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36366974
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36303061
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36138418
73TAF15_26573619_Chip-Seq_HEK293_Human1.35862168
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.35135828
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34594937
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.33678702
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.33643560
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33517575
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33138204
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30406127
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30325454
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30230294
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30071222
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28034674
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27780412
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27050484
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26314838
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24314947
89CLOCK_20551151_ChIP-Seq_293T_Human1.23265105
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23137756
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22647885
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.21363334
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.18280116
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17918411
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16711420
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16543616
97P300_19829295_ChIP-Seq_ESCs_Human1.15983450
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15943725
99KDM2B_26808549_Chip-Seq_K562_Human1.15148517
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14651540
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13925510
102AR_25329375_ChIP-Seq_VCAP_Human1.13811356
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13429227
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13207093
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11198363
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11081820
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.11030596
108* AR_19668381_ChIP-Seq_PC3_Human1.10936542
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10905829
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10361680
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.09861810
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09344525
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.08901744
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08570403
115* STAT3_23295773_ChIP-Seq_U87_Human1.07369549
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.06262932
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.06120291
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05711925
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04737473
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04639934
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04060734
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03642957
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03279763
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02819155
125AHR_22903824_ChIP-Seq_MCF-7_Human1.01816438
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99972787
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99436260
128OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98928989
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98683010
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98426139
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97673578
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97657965
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96700745
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96483901
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96254619
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95810718
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.94928520
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.94823702
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93921582
140CTCF_27219007_Chip-Seq_Bcells_Human0.93313317
141TCF4_23295773_ChIP-Seq_U87_Human0.93143203
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91936750
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90870170
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90229288
145RNF2_27304074_Chip-Seq_NSC_Mouse0.90023454
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.89448187
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88405001
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.87435697
149ZNF274_21170338_ChIP-Seq_K562_Hela0.86458443
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.86290894
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.86231841
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.85788743
153TET1_21490601_ChIP-Seq_MESCs_Mouse0.85745672
154YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85334147
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83625725
156* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82436107
157* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82004821
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81605252
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81491969
160RUNX2_22187159_ChIP-Seq_PCA_Human0.80944819
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80181081
162KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78745339
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78522095
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.78158036
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.77775316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.48070459
2MP0003880_abnormal_central_pattern5.14012139
3MP0003635_abnormal_synaptic_transmissio4.16103423
4MP0009745_abnormal_behavioral_response3.57242270
5MP0002064_seizures3.38124227
6MP0009046_muscle_twitch3.35269796
7MP0001968_abnormal_touch/_nociception3.30188265
8MP0002063_abnormal_learning/memory/cond3.26595159
9MP0004270_analgesia3.21604345
10MP0002736_abnormal_nociception_after2.81520335
11MP0003705_abnormal_hypodermis_morpholog2.80855722
12MP0002572_abnormal_emotion/affect_behav2.76234194
13MP0002272_abnormal_nervous_system2.71635031
14MP0005423_abnormal_somatic_nervous2.68840852
15MP0001501_abnormal_sleep_pattern2.65763801
16MP0002822_catalepsy2.53477884
17MP0002734_abnormal_mechanical_nocicepti2.47601387
18MP0002735_abnormal_chemical_nociception2.43976491
19MP0001486_abnormal_startle_reflex2.39089235
20MP0001440_abnormal_grooming_behavior2.17067364
21MP0002733_abnormal_thermal_nociception2.10657265
22MP0004858_abnormal_nervous_system2.08306973
23MP0001970_abnormal_pain_threshold2.05922033
24MP0005646_abnormal_pituitary_gland2.05485048
25MP0002067_abnormal_sensory_capabilities2.05478488
26MP0005058_abnormal_lysosome_morphology2.05004417
27MP0006276_abnormal_autonomic_nervous1.93371667
28MP0008569_lethality_at_weaning1.92386486
29MP0000566_synostosis1.80563767
30MP0001849_ear_inflammation1.78637290
31MP0002557_abnormal_social/conspecific_i1.78575256
32MP0010030_abnormal_orbit_morphology1.77058718
33MP0005623_abnormal_meninges_morphology1.76406752
34MP0001984_abnormal_olfaction1.72676509
35MP0004811_abnormal_neuron_physiology1.71544202
36MP0001348_abnormal_lacrimal_gland1.70544836
37MP0002089_abnormal_postnatal_growth/wei1.69128022
38MP0002184_abnormal_innervation1.67044252
39MP0004924_abnormal_behavior1.63375665
40MP0005386_behavior/neurological_phenoty1.63375665
41MP0002909_abnormal_adrenal_gland1.61819094
42MP0000678_abnormal_parathyroid_gland1.59048599
43MP0000778_abnormal_nervous_system1.56730601
44MP0003787_abnormal_imprinting1.55323784
45MP0003122_maternal_imprinting1.53716172
46MP0003329_amyloid_beta_deposits1.53567190
47MP0000955_abnormal_spinal_cord1.50895628
48MP0004142_abnormal_muscle_tone1.49523939
49MP0001502_abnormal_circadian_rhythm1.48861338
50MP0005645_abnormal_hypothalamus_physiol1.44453038
51MP0002249_abnormal_larynx_morphology1.44389215
52MP0003633_abnormal_nervous_system1.40397755
53MP0002066_abnormal_motor_capabilities/c1.40132242
54* MP0002882_abnormal_neuron_morphology1.38352041
55MP0003690_abnormal_glial_cell1.38052531
56MP0001346_abnormal_lacrimal_gland1.36611789
57MP0001905_abnormal_dopamine_level1.34676707
58MP0003879_abnormal_hair_cell1.34108737
59MP0008260_abnormal_autophagy1.27872642
60MP0009780_abnormal_chondrocyte_physiolo1.27528065
61MP0005257_abnormal_intraocular_pressure1.27137430
62MP0006292_abnormal_olfactory_placode1.25622483
63MP0003075_altered_response_to1.24327199
64MP0001529_abnormal_vocalization1.19651703
65MP0000579_abnormal_nail_morphology1.16535578
66MP0005666_abnormal_adipose_tissue1.16407607
67MP0009672_abnormal_birth_weight1.15846462
68MP0000751_myopathy1.15151626
69MP0005670_abnormal_white_adipose1.14080498
70MP0003631_nervous_system_phenotype1.14015661
71* MP0003566_abnormal_cell_adhesion1.12313152
72MP0004185_abnormal_adipocyte_glucose1.10823494
73MP0004510_myositis1.10673855
74MP0005464_abnormal_platelet_physiology1.06526048
75MP0002229_neurodegeneration1.02504577
76MP0004272_abnormal_basement_membrane1.00335913
77MP0008872_abnormal_physiological_respon0.99982105
78MP0001188_hyperpigmentation0.98178218
79MP0002877_abnormal_melanocyte_morpholog0.97638834
80MP0008874_decreased_physiological_sensi0.96804432
81MP0009840_abnormal_foam_cell0.95820454
82MP0002152_abnormal_brain_morphology0.95681458
83MP0000569_abnormal_digit_pigmentation0.93853701
84MP0001730_embryonic_growth_arrest0.93100904
85MP0005394_taste/olfaction_phenotype0.92262006
86MP0005499_abnormal_olfactory_system0.92262006
87MP0010386_abnormal_urinary_bladder0.92157373
88MP0004885_abnormal_endolymph0.92085088
89MP0000003_abnormal_adipose_tissue0.91990159
90MP0004742_abnormal_vestibular_system0.91492664
91MP0002069_abnormal_eating/drinking_beha0.90714993
92MP0005535_abnormal_body_temperature0.90662548
93MP0003861_abnormal_nervous_system0.89416678
94MP0005167_abnormal_blood-brain_barrier0.89252936
95MP0001299_abnormal_eye_distance/0.89007605
96MP0001177_atelectasis0.87420414
97MP0000747_muscle_weakness0.86334034
98MP0001963_abnormal_hearing_physiology0.86053093
99MP0005375_adipose_tissue_phenotype0.85161814
100MP0003634_abnormal_glial_cell0.83598714
101MP0000013_abnormal_adipose_tissue0.82720295
102MP0005076_abnormal_cell_differentiation0.78380472
103MP0000920_abnormal_myelination0.76839962
104MP0000537_abnormal_urethra_morphology0.76061861
105MP0003938_abnormal_ear_development0.75265773
106MP0003183_abnormal_peptide_metabolism0.74231661
107MP0004130_abnormal_muscle_cell0.73576632
108MP0003172_abnormal_lysosome_physiology0.73200667
109MP0003632_abnormal_nervous_system0.72809890
110MP0002876_abnormal_thyroid_physiology0.72287433
111MP0005551_abnormal_eye_electrophysiolog0.71986397
112MP0008961_abnormal_basal_metabolism0.71901394
113MP0000604_amyloidosis0.71112064
114MP0002090_abnormal_vision0.70423658
115MP0004145_abnormal_muscle_electrophysio0.69544698
116MP0003111_abnormal_nucleus_morphology0.69364828
117MP0002752_abnormal_somatic_nervous0.69189309
118MP0005501_abnormal_skin_physiology0.69138757
119MP0003453_abnormal_keratinocyte_physiol0.69122684
120MP0003942_abnormal_urinary_system0.69036009
121MP0010234_abnormal_vibrissa_follicle0.66661124
122MP0001664_abnormal_digestion0.66430393
123MP0008932_abnormal_embryonic_tissue0.64730025
124MP0003283_abnormal_digestive_organ0.63380593
125MP0004087_abnormal_muscle_fiber0.63235506
126MP0005171_absent_coat_pigmentation0.63057248
127MP0010630_abnormal_cardiac_muscle0.61764011
128MP0000759_abnormal_skeletal_muscle0.60175273
129MP0001986_abnormal_taste_sensitivity0.60076456
130MP0004085_abnormal_heartbeat0.58165459
131MP0004484_altered_response_of0.54825729
132MP0005409_darkened_coat_color0.54581149
133MP0003123_paternal_imprinting0.52952215
134MP0002638_abnormal_pupillary_reflex0.51389078
135MP0005310_abnormal_salivary_gland0.50810552
136MP0000631_abnormal_neuroendocrine_gland0.50746743
137MP0003137_abnormal_impulse_conducting0.49073943
138MP0001943_abnormal_respiration0.47791106
139MP0003956_abnormal_body_size0.47326986
140MP0010769_abnormal_survival0.46779142
141MP0002837_dystrophic_cardiac_calcinosis0.46205582
142MP0004233_abnormal_muscle_weight0.46205383

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.30149746
2Myokymia (HP:0002411)7.16471647
3Focal seizures (HP:0007359)5.82249142
4Visual hallucinations (HP:0002367)5.48715292
5Febrile seizures (HP:0002373)5.03292297
6Atonic seizures (HP:0010819)4.89389376
7Epileptic encephalopathy (HP:0200134)4.80241855
8Supranuclear gaze palsy (HP:0000605)4.50635288
9Absence seizures (HP:0002121)4.18867209
10Generalized tonic-clonic seizures (HP:0002069)4.13757590
11Dialeptic seizures (HP:0011146)3.89809571
12Progressive cerebellar ataxia (HP:0002073)3.86422902
13Obstructive sleep apnea (HP:0002870)3.73475620
14Ankle clonus (HP:0011448)3.72843028
15Action tremor (HP:0002345)3.69548785
16Insomnia (HP:0100785)3.56748609
17Impaired vibration sensation in the lower limbs (HP:0002166)3.48796754
18Hyperacusis (HP:0010780)3.45009412
19Abnormal gallbladder physiology (HP:0012438)3.40028994
20Cholecystitis (HP:0001082)3.40028994
21Depression (HP:0000716)3.27522843
22Abnormal eating behavior (HP:0100738)3.24800244
23Mutism (HP:0002300)3.23146794
24Distal upper limb amyotrophy (HP:0007149)3.21504577
25Upper limb amyotrophy (HP:0009129)3.21504577
26Broad-based gait (HP:0002136)3.18657741
27Anxiety (HP:0000739)3.05504377
28Spastic gait (HP:0002064)3.04543164
29Poor eye contact (HP:0000817)3.04054769
30Gaze-evoked nystagmus (HP:0000640)3.03350818
31Urinary bladder sphincter dysfunction (HP:0002839)3.03187798
32Dysmetria (HP:0001310)2.96495462
33Postural instability (HP:0002172)2.95372816
34Failure to thrive in infancy (HP:0001531)2.90216008
35Hyperventilation (HP:0002883)2.89291470
36Abnormality of glycolysis (HP:0004366)2.87429446
37Hand muscle atrophy (HP:0009130)2.86751544
38Dysdiadochokinesis (HP:0002075)2.81843655
39Abnormal social behavior (HP:0012433)2.74740185
40Impaired social interactions (HP:0000735)2.74740185
41Lower limb amyotrophy (HP:0007210)2.73577464
42Amblyopia (HP:0000646)2.73080297
43Distal lower limb amyotrophy (HP:0008944)2.71297513
44Pointed chin (HP:0000307)2.69623444
45Abnormality of the Achilles tendon (HP:0005109)2.65737934
46Abnormality of binocular vision (HP:0011514)2.65013925
47Diplopia (HP:0000651)2.65013925
48Hemiparesis (HP:0001269)2.63478375
49Urinary urgency (HP:0000012)2.62496700
50Progressive inability to walk (HP:0002505)2.62022296
51Achilles tendon contracture (HP:0001771)2.61793348
52Abnormality of the lower motor neuron (HP:0002366)2.59929897
53Truncal ataxia (HP:0002078)2.59176535
54Hemiplegia (HP:0002301)2.58065053
55Tetraplegia (HP:0002445)2.53197838
56Ventricular fibrillation (HP:0001663)2.51610589
57Agitation (HP:0000713)2.47300350
58Bradykinesia (HP:0002067)2.46642566
59Drooling (HP:0002307)2.42963820
60Excessive salivation (HP:0003781)2.42963820
61Polyphagia (HP:0002591)2.39794972
62Increased connective tissue (HP:0009025)2.38100596
63Peripheral hypomyelination (HP:0007182)2.37976193
64Torticollis (HP:0000473)2.34833390
65Lower limb muscle weakness (HP:0007340)2.34010078
66Turricephaly (HP:0000262)2.34007968
67Abnormality of the aortic arch (HP:0012303)2.33852295
68Limb dystonia (HP:0002451)2.30785698
69Status epilepticus (HP:0002133)2.30766879
70Psychosis (HP:0000709)2.30311171
71Neurofibrillary tangles (HP:0002185)2.30226905
72Long palpebral fissure (HP:0000637)2.27260922
73Fetal akinesia sequence (HP:0001989)2.27008762
74Aplasia involving bones of the upper limbs (HP:0009823)2.26921338
75Aplasia of the phalanges of the hand (HP:0009802)2.26921338
76Aplasia involving bones of the extremities (HP:0009825)2.26921338
77Menorrhagia (HP:0000132)2.24366753
78Impaired smooth pursuit (HP:0007772)2.24302481
79Papilledema (HP:0001085)2.23890681
80Abnormality of the corticospinal tract (HP:0002492)2.23576511
81Incomplete penetrance (HP:0003829)2.22822890
82Focal dystonia (HP:0004373)2.20952842
83Intention tremor (HP:0002080)2.20685812
84Scanning speech (HP:0002168)2.18572863
85Genetic anticipation (HP:0003743)2.17653506
86Increased serum pyruvate (HP:0003542)2.16950327
87Stereotypic behavior (HP:0000733)2.15403151
88Cerebral inclusion bodies (HP:0100314)2.15335316
89Pheochromocytoma (HP:0002666)2.15289253
90Abnormal hair whorl (HP:0010721)2.15206361
91Shallow orbits (HP:0000586)2.11846304
92Neuronal loss in central nervous system (HP:0002529)2.11259622
93Distal lower limb muscle weakness (HP:0009053)2.11210500
94Absent speech (HP:0001344)2.09423636
95Narrow nasal bridge (HP:0000446)2.08547214
96Epileptiform EEG discharges (HP:0011182)2.08509704
97Inability to walk (HP:0002540)2.08089427
98Overriding aorta (HP:0002623)2.07019285
99Axonal loss (HP:0003447)2.05203941
100Dysmetric saccades (HP:0000641)2.03425708
101Impaired vibratory sensation (HP:0002495)2.03333563
102Craniofacial dystonia (HP:0012179)2.00807048
103Rapidly progressive (HP:0003678)2.00610210
104Apathy (HP:0000741)2.00326257
105Generalized myoclonic seizures (HP:0002123)1.99359654
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.99255714
107Spinal canal stenosis (HP:0003416)1.99238190
108Bronchomalacia (HP:0002780)1.97373158
109Purpura (HP:0000979)1.97065974
110EEG with generalized epileptiform discharges (HP:0011198)1.96736293
111Annular pancreas (HP:0001734)1.96391888
112Impaired pain sensation (HP:0007328)1.96367529
113Abnormality of pain sensation (HP:0010832)1.96367529
114Neuroendocrine neoplasm (HP:0100634)1.95679044
115Distal sensory impairment (HP:0002936)1.95452542
116Cerebral hypomyelination (HP:0006808)1.93561654
117Renal duplication (HP:0000075)1.93075119
118Abnormality of ocular smooth pursuit (HP:0000617)1.93047508
119Stridor (HP:0010307)1.91646284
120Rigidity (HP:0002063)1.90376542
121Sleep apnea (HP:0010535)1.90137193
122Nuclear cataract (HP:0100018)1.89463324
123Akinesia (HP:0002304)1.89462851
124Cerebral aneurysm (HP:0004944)1.89299792
125Specific learning disability (HP:0001328)1.88762058
126Athetosis (HP:0002305)1.88596427
127Abnormal EKG (HP:0003115)1.88561223
128Upper limb muscle weakness (HP:0003484)1.87492271
129Insidious onset (HP:0003587)1.86421658
130Termporal pattern (HP:0011008)1.86421658
131Hypsarrhythmia (HP:0002521)1.86100543
132Hypercortisolism (HP:0001578)1.85999197
133Hyperparathyroidism (HP:0000843)1.85403758
134Megalencephaly (HP:0001355)1.84189148
135Abnormality of liposaccharide metabolism (HP:0010968)1.83444243
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.83444243
137Abnormality of glycolipid metabolism (HP:0010969)1.83444243
138Hyperthyroidism (HP:0000836)1.82349137
139Hammertoe (HP:0001765)1.81533704
140Gait imbalance (HP:0002141)1.81375484
141Gait ataxia (HP:0002066)1.81200088
142Protruding tongue (HP:0010808)1.79800819
143Protrusio acetabuli (HP:0003179)1.79758975
144Neonatal death (HP:0003811)1.79609558
145Increased mean platelet volume (HP:0011877)1.79556558
146Abnormality of salivation (HP:0100755)1.79344852
147Premature rupture of membranes (HP:0001788)1.78711148
148Elfin facies (HP:0004428)1.78611128
149Hypoventilation (HP:0002791)1.78489342
150Disproportionate tall stature (HP:0001519)1.77432501
151Bundle branch block (HP:0011710)1.77323248
152Resting tremor (HP:0002322)1.77245454
153Diminished motivation (HP:0000745)1.75895016
154Deep palmar crease (HP:0006191)1.71699406
155Ulnar bowing (HP:0003031)1.70866360
156Vertebral compression fractures (HP:0002953)1.69213257
157Increased nuchal translucency (HP:0010880)1.68096473
158Precocious puberty (HP:0000826)1.67006681
159Ragged-red muscle fibers (HP:0003200)1.65006751
160Truncus arteriosus (HP:0001660)1.64987924
161Clonus (HP:0002169)1.64934657
162Xanthomatosis (HP:0000991)1.64584254
163Foot dorsiflexor weakness (HP:0009027)1.59451902
164Increased variability in muscle fiber diameter (HP:0003557)1.58831181
165Broad distal phalanx of finger (HP:0009836)1.58538892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67717132
2EPHA44.11814788
3MAP3K93.78159341
4TAOK23.38014097
5TRIB33.02881800
6RIPK42.71296123
7INSRR2.61348086
8MINK12.57260970
9SMG12.53389993
10ICK2.52133831
11MAP3K42.48411303
12MAP3K122.42444414
13MAP2K72.28855844
14EEF2K2.27844212
15RIPK12.27758491
16DAPK22.26627348
17KSR22.25857916
18CASK2.13361755
19PAK62.05481129
20SIK11.94879158
21MARK11.90154791
22CAMKK11.88938892
23NTRK11.84784083
24ARAF1.78699745
25GRK51.76135838
26PRKD31.68511007
27MAP3K131.67954008
28TNIK1.67916385
29CDK121.65080408
30NTRK21.60529037
31FES1.56754442
32DAPK11.55684511
33MAP2K41.55479768
34KSR11.52745668
35CDK51.45255003
36BRAF1.45152105
37STK381.41855345
38CAMKK21.40903996
39IRAK31.40091059
40PRPF4B1.33975804
41PLK21.33421373
42MAP3K21.29737381
43MAP3K111.24663001
44BMX1.24562138
45CDK191.23344536
46TESK11.22265462
47PRKCG1.20357612
48MAPK131.19947577
49MAP2K61.18507610
50SIK21.14478930
51BRSK11.10594413
52TNK21.09933115
53UHMK11.09602183
54CAMK11.08705571
55NME21.08702551
56PTK21.03661767
57PKN20.99061219
58PTK2B0.97359476
59BMPR20.96489789
60CAMK2A0.96032461
61FGFR40.95136024
62CAMK1D0.94588754
63EPHA20.93680685
64PDGFRA0.93345264
65PHKG10.89812777
66PHKG20.89812777
67RAF10.86629734
68ERN10.85347543
69MAP3K80.84904443
70PRKCH0.83492230
71TTN0.82920575
72MAP3K70.82911365
73AURKA0.82677310
74CAMK40.80165247
75MAP3K10.77832045
76CDK180.77721561
77PRKD20.76765095
78PNCK0.76653427
79SGK2230.76579307
80SGK4940.76579307
81ALK0.75576047
82MARK20.75367418
83CDK150.74185389
84LMTK20.73786439
85CDK140.73770327
86MTOR0.73762118
87CAMK2B0.72752641
88IRAK20.72675638
89PINK10.72056619
90SGK20.70982567
91PAK10.68260369
92STK110.67842980
93PDPK10.66559068
94PKN10.65214545
95SGK30.65090212
96TESK20.64704918
97NEK60.64536137
98RET0.63419066
99CDK11A0.63060285
100PDK10.62935409
101CAMK1G0.62807846
102OXSR10.61903485
103GRK70.61888608
104CDC42BPA0.58584043
105PRKCE0.58182872
106RPS6KA20.58135991
107SGK10.57100364
108PAK30.57029456
109PAK40.56512745
110TAOK10.55649392
111NME10.55092989
112SIK30.52725052
113MAPK120.50676343
114WNK10.50529228
115CAMK2G0.50495773
116TYRO30.48671536
117MAP2K10.48594058
118FER0.47892153
119DAPK30.47634105
120CAMK2D0.47312296
121ILK0.47183985
122PIM20.46559340
123PRKG20.45480156
124EPHB10.45392811
125PAK20.45032257
126PRKCZ0.43455512
127AKT20.43052418
128FGR0.42797355
129LIMK10.41371028
130MAP3K50.40112886
131ADRBK20.39816678
132HIPK20.38273805
133DYRK1A0.37793599
134LATS20.37709147
135RPS6KA30.37453419
136DMPK0.36265485
137MAPK100.36161772
138MAPK110.35743361
139MAPK70.35524374
140SYK0.34655850
141TLK10.33604803
142FYN0.33579583
143ROCK20.32831744
144CDK70.27332481

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70442935
2Synaptic vesicle cycle_Homo sapiens_hsa047213.67215582
3Olfactory transduction_Homo sapiens_hsa047402.81068153
4Circadian entrainment_Homo sapiens_hsa047132.69714127
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60439643
6GABAergic synapse_Homo sapiens_hsa047272.59970493
7Morphine addiction_Homo sapiens_hsa050322.58640972
8Long-term potentiation_Homo sapiens_hsa047202.50074135
9Glutamatergic synapse_Homo sapiens_hsa047242.48269514
10Amphetamine addiction_Homo sapiens_hsa050312.32054964
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15616741
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14953269
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09973031
14Salivary secretion_Homo sapiens_hsa049702.04388801
15Biosynthesis of amino acids_Homo sapiens_hsa012302.03445780
16Dopaminergic synapse_Homo sapiens_hsa047282.01053236
17Collecting duct acid secretion_Homo sapiens_hsa049661.98647435
18Vitamin B6 metabolism_Homo sapiens_hsa007501.97601900
19Insulin secretion_Homo sapiens_hsa049111.94967763
20Taste transduction_Homo sapiens_hsa047421.86073933
21Cholinergic synapse_Homo sapiens_hsa047251.85415324
22Gastric acid secretion_Homo sapiens_hsa049711.79883231
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69260513
24Serotonergic synapse_Homo sapiens_hsa047261.68267678
25Oxytocin signaling pathway_Homo sapiens_hsa049211.66114442
26Long-term depression_Homo sapiens_hsa047301.61032116
27Calcium signaling pathway_Homo sapiens_hsa040201.58880951
28Pentose phosphate pathway_Homo sapiens_hsa000301.57967798
29Renin secretion_Homo sapiens_hsa049241.55822870
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53434481
31Cocaine addiction_Homo sapiens_hsa050301.49349162
32GnRH signaling pathway_Homo sapiens_hsa049121.45888648
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43897860
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43425707
35Arginine biosynthesis_Homo sapiens_hsa002201.37241897
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32659285
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31430413
38Gap junction_Homo sapiens_hsa045401.27123624
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.26793419
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24586200
41cAMP signaling pathway_Homo sapiens_hsa040241.23475453
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20334646
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18913882
44Cardiac muscle contraction_Homo sapiens_hsa042601.18210649
45Sulfur relay system_Homo sapiens_hsa041221.16579111
46Type II diabetes mellitus_Homo sapiens_hsa049301.15024730
47Carbon metabolism_Homo sapiens_hsa012001.13776065
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11745746
49Vibrio cholerae infection_Homo sapiens_hsa051101.11344076
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11185765
51Fructose and mannose metabolism_Homo sapiens_hsa000511.09425077
52Arginine and proline metabolism_Homo sapiens_hsa003301.09140498
53Glioma_Homo sapiens_hsa052141.08406129
54Estrogen signaling pathway_Homo sapiens_hsa049151.07848830
55Galactose metabolism_Homo sapiens_hsa000521.01567659
56Notch signaling pathway_Homo sapiens_hsa043301.00014179
57ErbB signaling pathway_Homo sapiens_hsa040120.99760179
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97471545
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96860872
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96668079
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.96562142
62Axon guidance_Homo sapiens_hsa043600.94502325
63Dorso-ventral axis formation_Homo sapiens_hsa043200.92821641
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90091354
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89160627
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89060735
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.86430451
68AMPK signaling pathway_Homo sapiens_hsa041520.85995566
69Bile secretion_Homo sapiens_hsa049760.85714890
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.84912374
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.83439283
72Melanogenesis_Homo sapiens_hsa049160.82952325
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79535167
74Type I diabetes mellitus_Homo sapiens_hsa049400.79455344
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78934374
76Choline metabolism in cancer_Homo sapiens_hsa052310.77291923
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.76981050
78MAPK signaling pathway_Homo sapiens_hsa040100.76254620
79ECM-receptor interaction_Homo sapiens_hsa045120.74134030
80Pancreatic secretion_Homo sapiens_hsa049720.73726187
81Chronic myeloid leukemia_Homo sapiens_hsa052200.73523667
82Bladder cancer_Homo sapiens_hsa052190.72481435
83Dilated cardiomyopathy_Homo sapiens_hsa054140.67308053
84HIF-1 signaling pathway_Homo sapiens_hsa040660.67039385
85Focal adhesion_Homo sapiens_hsa045100.65243387
86Prion diseases_Homo sapiens_hsa050200.64603656
87Rheumatoid arthritis_Homo sapiens_hsa053230.63724071
88Alzheimers disease_Homo sapiens_hsa050100.63242830
89Phototransduction_Homo sapiens_hsa047440.62822809
90African trypanosomiasis_Homo sapiens_hsa051430.62387428
91Phenylalanine metabolism_Homo sapiens_hsa003600.60750583
92Thyroid cancer_Homo sapiens_hsa052160.59664933
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59632354
94Inositol phosphate metabolism_Homo sapiens_hsa005620.59371268
95Oocyte meiosis_Homo sapiens_hsa041140.58892437
96Endocytosis_Homo sapiens_hsa041440.58760501
97Other glycan degradation_Homo sapiens_hsa005110.57832643
98Chemokine signaling pathway_Homo sapiens_hsa040620.57457156
99Oxidative phosphorylation_Homo sapiens_hsa001900.57043735
100DNA replication_Homo sapiens_hsa030300.56365207
101Renal cell carcinoma_Homo sapiens_hsa052110.56303188
102Ras signaling pathway_Homo sapiens_hsa040140.55719014
103Thyroid hormone synthesis_Homo sapiens_hsa049180.54184998
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53912952
105VEGF signaling pathway_Homo sapiens_hsa043700.53698567
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52672232
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52105396
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52076930
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52066134
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51444677
111Hippo signaling pathway_Homo sapiens_hsa043900.50556739
112Rap1 signaling pathway_Homo sapiens_hsa040150.48400373
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47776453
114Phagosome_Homo sapiens_hsa041450.46654618
115Wnt signaling pathway_Homo sapiens_hsa043100.46494962
116Adherens junction_Homo sapiens_hsa045200.46485435
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46464749
118Proteoglycans in cancer_Homo sapiens_hsa052050.46239420
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.45187900
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44190086
121mTOR signaling pathway_Homo sapiens_hsa041500.42134605
122Non-small cell lung cancer_Homo sapiens_hsa052230.41816006
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40720608
124Salmonella infection_Homo sapiens_hsa051320.39581563
125Parkinsons disease_Homo sapiens_hsa050120.39070690
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38864138
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37884715
128Alcoholism_Homo sapiens_hsa050340.37731969
129Circadian rhythm_Homo sapiens_hsa047100.37205036
130Tuberculosis_Homo sapiens_hsa051520.35994204
131Insulin signaling pathway_Homo sapiens_hsa049100.35829403
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35330480
133Lysosome_Homo sapiens_hsa041420.35010696
134Glucagon signaling pathway_Homo sapiens_hsa049220.32843177
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32197411
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32184549
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31616402
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31539964
139Endometrial cancer_Homo sapiens_hsa052130.31047255

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »