NCMAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte development (GO:0002063)9.28543864
2keratan sulfate catabolic process (GO:0042340)9.02303622
3notochord development (GO:0030903)8.52098320
4limb bud formation (GO:0060174)7.58983555
5collagen fibril organization (GO:0030199)7.46942025
6sphingomyelin metabolic process (GO:0006684)6.99602846
7positive regulation of extracellular matrix organization (GO:1903055)6.51627158
8negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.35541636
9cell-cell junction maintenance (GO:0045217)6.21755549
10cartilage development (GO:0051216)5.93084162
11nucleotide-sugar biosynthetic process (GO:0009226)5.76573094
12proteoglycan metabolic process (GO:0006029)5.18859264
13collagen catabolic process (GO:0030574)5.16510028
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.00529938
15chondrocyte differentiation (GO:0002062)4.91326674
16collagen metabolic process (GO:0032963)4.91065118
17behavioral response to nicotine (GO:0035095)4.89301519
18protein retention in ER lumen (GO:0006621)4.83686977
19embryonic skeletal joint morphogenesis (GO:0060272)4.80815828
20positive regulation of chondrocyte differentiation (GO:0032332)4.77988126
21regulation of extracellular matrix disassembly (GO:0010715)4.67713473
22multicellular organismal catabolic process (GO:0044243)4.67498145
23replacement ossification (GO:0036075)4.64986318
24endochondral ossification (GO:0001958)4.64986318
25chondroitin sulfate biosynthetic process (GO:0030206)4.60985216
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.57668573
27skeletal system development (GO:0001501)4.57170237
28multicellular organismal macromolecule metabolic process (GO:0044259)4.53584190
29male sex determination (GO:0030238)4.53046182
30cell junction maintenance (GO:0034331)4.46086281
31neuronal action potential propagation (GO:0019227)4.40229003
32regulation of extracellular matrix organization (GO:1903053)4.32384505
33fucose catabolic process (GO:0019317)4.31035721
34L-fucose metabolic process (GO:0042354)4.31035721
35L-fucose catabolic process (GO:0042355)4.31035721
36multicellular organismal metabolic process (GO:0044236)4.30550596
37cellular response to BMP stimulus (GO:0071773)4.29433201
38response to BMP (GO:0071772)4.29433201
39hypotonic response (GO:0006971)4.20648565
40cellular glucuronidation (GO:0052695)4.20081891
41endocardial cushion morphogenesis (GO:0003203)4.16852181
42positive regulation of cartilage development (GO:0061036)4.09712817
43keratan sulfate biosynthetic process (GO:0018146)4.07335921
44response to gravity (GO:0009629)4.06969191
45extracellular matrix disassembly (GO:0022617)4.03883878
46UDP-N-acetylglucosamine metabolic process (GO:0006047)3.97466282
47tryptophan catabolic process (GO:0006569)3.97133114
48indole-containing compound catabolic process (GO:0042436)3.97133114
49indolalkylamine catabolic process (GO:0046218)3.97133114
50detection of mechanical stimulus involved in sensory perception (GO:0050974)3.96816783
51uronic acid metabolic process (GO:0006063)3.90995582
52glucuronate metabolic process (GO:0019585)3.90995582
53regulation of transforming growth factor beta2 production (GO:0032909)3.88287425
54water-soluble vitamin biosynthetic process (GO:0042364)3.87798098
55lipopolysaccharide biosynthetic process (GO:0009103)3.87354565
56iron ion import (GO:0097286)3.79530789
57endothelial cell morphogenesis (GO:0001886)3.79409720
58indolalkylamine metabolic process (GO:0006586)3.78376904
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70831402
60DNA deamination (GO:0045006)3.69592378
61peripheral nervous system development (GO:0007422)3.66405789
62connective tissue development (GO:0061448)3.64899152
63respiratory chain complex IV assembly (GO:0008535)3.61339827
64response to pheromone (GO:0019236)3.58654581
65mesenchyme morphogenesis (GO:0072132)3.58013979
66peptidyl-proline hydroxylation (GO:0019511)3.56974959
67detection of light stimulus involved in sensory perception (GO:0050962)3.52367645
68detection of light stimulus involved in visual perception (GO:0050908)3.52367645
69negative regulation of gluconeogenesis (GO:0045721)3.51654788
70kynurenine metabolic process (GO:0070189)3.48423741
71peripheral nervous system axon ensheathment (GO:0032292)3.46254405
72myelination in peripheral nervous system (GO:0022011)3.46254405
73extracellular matrix organization (GO:0030198)3.44164308
74cellular ketone body metabolic process (GO:0046950)3.44076294
75cholesterol biosynthetic process (GO:0006695)3.43805490
76extracellular structure organization (GO:0043062)3.43510549
77protein complex biogenesis (GO:0070271)3.42616916
78tryptophan metabolic process (GO:0006568)3.39368331
79regulation of glucokinase activity (GO:0033131)3.39166879
80regulation of hexokinase activity (GO:1903299)3.39166879
81chondrocyte proliferation (GO:0035988)3.38568948
82platelet dense granule organization (GO:0060155)3.35038682
83negative regulation of glycogen biosynthetic process (GO:0045719)3.34351975
84axoneme assembly (GO:0035082)3.32147228
85type B pancreatic cell development (GO:0003323)3.30631527
86regulation of chondrocyte differentiation (GO:0032330)3.29200527
87nucleotide-sugar metabolic process (GO:0009225)3.26310040
88regulation of cell maturation (GO:1903429)3.25384077
89kidney morphogenesis (GO:0060993)3.24590777
90Golgi transport vesicle coating (GO:0048200)3.24546616
91COPI coating of Golgi vesicle (GO:0048205)3.24546616
92short-term memory (GO:0007614)3.24418500
93glycoprotein metabolic process (GO:0009100)3.24076453
94cytochrome complex assembly (GO:0017004)3.23576431
95negative regulation of smooth muscle cell differentiation (GO:0051151)3.21415344
96negative regulation of glycogen metabolic process (GO:0070874)3.20616473
97regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.20462514
98ER overload response (GO:0006983)3.20373297
99epithelial cilium movement (GO:0003351)3.18991257
100somite development (GO:0061053)3.18549672
101lipopolysaccharide metabolic process (GO:0008653)3.17927345
102mitochondrial respiratory chain complex assembly (GO:0033108)3.17848050
103cellular biogenic amine catabolic process (GO:0042402)3.16484970
104amine catabolic process (GO:0009310)3.16484970
105COPII vesicle coating (GO:0048208)3.14849327
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14077606
107mitochondrial respiratory chain complex I assembly (GO:0032981)3.14077606
108NADH dehydrogenase complex assembly (GO:0010257)3.14077606
109nephron epithelium morphogenesis (GO:0072088)3.13602557
110nephron tubule morphogenesis (GO:0072078)3.13602557
111sterol biosynthetic process (GO:0016126)3.13116310
112preassembly of GPI anchor in ER membrane (GO:0016254)3.13024329
113nonmotile primary cilium assembly (GO:0035058)3.12830569
114axon ensheathment (GO:0008366)3.12555606
115ensheathment of neurons (GO:0007272)3.12555606
116keratan sulfate metabolic process (GO:0042339)3.10590220
117limb development (GO:0060173)3.10404995
118appendage development (GO:0048736)3.10404995
119regulation of plasminogen activation (GO:0010755)3.10120853
120ketone body metabolic process (GO:1902224)3.09467362
121response to follicle-stimulating hormone (GO:0032354)3.08671702
122glycosaminoglycan biosynthetic process (GO:0006024)3.05194607
123aminoglycan biosynthetic process (GO:0006023)3.00086894
124indole-containing compound metabolic process (GO:0042430)2.99930460
125reflex (GO:0060004)2.99835702
126endodermal cell differentiation (GO:0035987)2.99589802
127positive regulation of hormone biosynthetic process (GO:0046886)2.98804559
128protein polyglutamylation (GO:0018095)2.97900790
129piRNA metabolic process (GO:0034587)2.97805046
130mannosylation (GO:0097502)2.96721179
131protein-cofactor linkage (GO:0018065)2.96510089
132regulation of energy homeostasis (GO:2000505)2.96099607
133photoreceptor cell differentiation (GO:0046530)2.95647094
134eye photoreceptor cell differentiation (GO:0001754)2.95647094
135negative regulation of chemokine production (GO:0032682)2.95466646
136negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.95021596
137glycerophospholipid catabolic process (GO:0046475)2.92918894
138regulation of metalloenzyme activity (GO:0048552)2.92757497
139regulation of bone mineralization (GO:0030500)2.89451248
140regulation of cartilage development (GO:0061035)2.89238085
141negative regulation of NF-kappaB import into nucleus (GO:0042347)2.88808272
142dopamine transport (GO:0015872)2.86399750
143negative regulation of telomere maintenance (GO:0032205)2.84209289
144regulation of cilium movement (GO:0003352)2.83256675
145retinal cone cell development (GO:0046549)2.79544796
146S-adenosylmethionine metabolic process (GO:0046500)2.78514513
147aromatic amino acid family catabolic process (GO:0009074)2.77320881
148transepithelial transport (GO:0070633)2.76189240
149primary amino compound metabolic process (GO:1901160)2.73810402
150sulfation (GO:0051923)2.72338147
151cilium morphogenesis (GO:0060271)2.71973881
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71582605
153auditory receptor cell stereocilium organization (GO:0060088)2.69462243
154signal peptide processing (GO:0006465)2.67066249
155cilium movement (GO:0003341)2.66295865
156neuronal action potential (GO:0019228)2.64172915
157photoreceptor cell maintenance (GO:0045494)2.63413570
158DNA methylation involved in gamete generation (GO:0043046)2.63292249
159cornea development in camera-type eye (GO:0061303)2.62779472
160regulation of hippo signaling (GO:0035330)2.59979970
161cilium organization (GO:0044782)2.59584077
162amino acid salvage (GO:0043102)2.59118540
163L-methionine salvage (GO:0071267)2.59118540
164L-methionine biosynthetic process (GO:0071265)2.59118540
165benzene-containing compound metabolic process (GO:0042537)2.57236676
166protein K11-linked deubiquitination (GO:0035871)2.56662176
167gamma-aminobutyric acid transport (GO:0015812)2.56647846
168protein localization to cilium (GO:0061512)2.54108826
169C4-dicarboxylate transport (GO:0015740)2.53962314
170oxidative demethylation (GO:0070989)2.53896402
171regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53602752
172purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53388109
1733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53388109
174serotonin metabolic process (GO:0042428)2.51849582
175regulation of meiosis I (GO:0060631)2.51389517
176cilium assembly (GO:0042384)2.51204686
177rhodopsin mediated signaling pathway (GO:0016056)2.50619187
178regulation of action potential (GO:0098900)2.49207945
179adaptation of signaling pathway (GO:0023058)2.48544364
180renal tubule morphogenesis (GO:0061333)2.48277930
181neural tube formation (GO:0001841)2.46654215
182mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46265931
183photoreceptor cell development (GO:0042461)2.45204966
184phosphatidylinositol acyl-chain remodeling (GO:0036149)2.44779359
185GPI anchor metabolic process (GO:0006505)2.44457204
186drug catabolic process (GO:0042737)2.44194150
187behavioral response to ethanol (GO:0048149)2.43429826
188basic amino acid transport (GO:0015802)2.41912978
189thyroid hormone metabolic process (GO:0042403)2.41325375
190polyol catabolic process (GO:0046174)2.39902424
191pseudouridine synthesis (GO:0001522)2.37989813
192startle response (GO:0001964)2.36126295
193ubiquinone biosynthetic process (GO:0006744)2.35676559
194nucleobase catabolic process (GO:0046113)2.34088280
195inner ear receptor stereocilium organization (GO:0060122)2.33822627
196reciprocal DNA recombination (GO:0035825)2.32611051
197cartilage development involved in endochondral bone morphogenesis (GO:0060351)11.8603646
198cartilage condensation (GO:0001502)10.4957720
199cell aggregation (GO:0098743)10.4957720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.34044370
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.20502145
3AR_21572438_ChIP-Seq_LNCaP_Human4.06850294
4ZNF274_21170338_ChIP-Seq_K562_Hela3.89949037
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.83460888
6VDR_22108803_ChIP-Seq_LS180_Human3.21838572
7GATA1_22025678_ChIP-Seq_K562_Human3.14119143
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.88120200
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.56574708
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46112984
11IGF1R_20145208_ChIP-Seq_DFB_Human2.39109129
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.30467666
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23632412
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.14644280
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.14549091
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06994106
17FUS_26573619_Chip-Seq_HEK293_Human2.06248897
18EZH2_22144423_ChIP-Seq_EOC_Human2.06218739
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05615734
20EWS_26573619_Chip-Seq_HEK293_Human2.02121944
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99578439
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98266430
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.97123253
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.94017295
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89707257
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89322703
27CJUN_26792858_Chip-Seq_BT549_Human1.85028804
28TAF15_26573619_Chip-Seq_HEK293_Human1.84625992
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80429821
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79259033
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.77311955
32GBX2_23144817_ChIP-Seq_PC3_Human1.77242147
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72637615
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70009600
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66794963
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66309533
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63439825
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62383665
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62383665
40BCAT_22108803_ChIP-Seq_LS180_Human1.61285762
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59788087
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.59528499
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58004083
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.57771373
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56250912
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55499107
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54549957
48TP53_22573176_ChIP-Seq_HFKS_Human1.53902231
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.53839186
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.52303958
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49470236
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48821012
53CBP_20019798_ChIP-Seq_JUKART_Human1.48821012
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48049446
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47703497
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47146758
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46580020
58AR_25329375_ChIP-Seq_VCAP_Human1.45989030
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44833694
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44662469
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44258228
62IRF1_19129219_ChIP-ChIP_H3396_Human1.43478937
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42228971
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42209560
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.41401665
66TCF4_23295773_ChIP-Seq_U87_Human1.41283125
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40624116
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40093944
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39574873
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.39574873
71NANOG_19829295_ChIP-Seq_ESCs_Human1.39545433
72SOX2_19829295_ChIP-Seq_ESCs_Human1.39545433
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38750188
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.38010138
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37831883
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37629427
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36991607
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36854064
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35730923
80P300_19829295_ChIP-Seq_ESCs_Human1.34153078
81SOX2_20726797_ChIP-Seq_SW620_Human1.33539236
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33080064
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33080064
84P53_22387025_ChIP-Seq_ESCs_Mouse1.31835431
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30439033
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.28489191
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.28318744
88SMAD4_21799915_ChIP-Seq_A2780_Human1.28142459
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27876865
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27787025
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27765938
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26727473
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.26618150
94REST_21632747_ChIP-Seq_MESCs_Mouse1.25755298
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25430113
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24733200
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.24264799
98GATA3_21878914_ChIP-Seq_MCF-7_Human1.24024198
99RUNX2_22187159_ChIP-Seq_PCA_Human1.23761369
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23645016
101MYC_18940864_ChIP-ChIP_HL60_Human1.23563301
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22637391
103AR_20517297_ChIP-Seq_VCAP_Human1.22270378
104GF1B_26923725_Chip-Seq_HPCs_Mouse1.22142782
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21481707
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.20873019
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20718425
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.20302948
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19536050
110NCOR_22424771_ChIP-Seq_293T_Human1.19248263
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.17897450
112CDX2_22108803_ChIP-Seq_LS180_Human1.17248568
113ER_23166858_ChIP-Seq_MCF-7_Human1.17005206
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16984673
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16394485
116P300_18555785_Chip-Seq_ESCs_Mouse1.15800826
117NMYC_18555785_Chip-Seq_ESCs_Mouse1.15765707
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15610833
119HOXB7_26014856_ChIP-Seq_BT474_Human1.15085828
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15048663
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.15003323
122SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14857688
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14811715
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14478893
125PHF8_20622853_ChIP-Seq_HELA_Human1.13421172
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12783201
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12156600
128CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11544891
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11227267
130ELK1_22589737_ChIP-Seq_MCF10A_Human1.11209283
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.10841196
132STAT3_23295773_ChIP-Seq_U87_Human1.10669088
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08505664
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07956453
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.07509069
136RNF2_27304074_Chip-Seq_NSC_Mouse1.07107267
137GATA2_21666600_ChIP-Seq_HMVEC_Human1.06849843
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06772371
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06446707
140NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05924391
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05924391
142MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05760907
143SOX2_18555785_Chip-Seq_ESCs_Mouse1.05736006
144TP53_18474530_ChIP-ChIP_U2OS_Human1.05409189
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05355342
146JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05218383
147TBL1_22424771_ChIP-Seq_293T_Human1.03416618
148OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03013874
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02560059
150ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02266933
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01855284
152ELK1_19687146_ChIP-ChIP_HELA_Human1.01823972
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01477121
154TCF4_22108803_ChIP-Seq_LS180_Human1.00508073
155SMAD1_18555785_Chip-Seq_ESCs_Mouse1.00239448
156FOXH1_21741376_ChIP-Seq_EPCs_Human0.95868272
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95514417
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95224173
159MYC_19829295_ChIP-Seq_ESCs_Human0.94221578
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93284140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004134_abnormal_chest_morphology5.94044369
2MP0002933_joint_inflammation5.32804068
3MP0005503_abnormal_tendon_morphology5.10152303
4MP0002282_abnormal_trachea_morphology4.01593464
5MP0004272_abnormal_basement_membrane3.49546812
6MP0000163_abnormal_cartilage_morphology3.48118925
7MP0009250_abnormal_appendicular_skeleto3.40000713
8MP0003646_muscle_fatigue3.18598686
9MP0009780_abnormal_chondrocyte_physiolo3.04191568
10MP0000569_abnormal_digit_pigmentation2.81807167
11MP0002089_abnormal_postnatal_growth/wei2.77606726
12MP0008877_abnormal_DNA_methylation2.76053988
13MP0002115_abnormal_skeleton_extremities2.73025599
14MP0008438_abnormal_cutaneous_collagen2.62278685
15MP0002102_abnormal_ear_morphology2.51093095
16MP0000751_myopathy2.50459145
17MP0005551_abnormal_eye_electrophysiolog2.50368172
18MP0002876_abnormal_thyroid_physiology2.48393235
19MP0001299_abnormal_eye_distance/2.47701833
20MP0008260_abnormal_autophagy2.44895502
21MP0001542_abnormal_bone_strength2.42406996
22MP0000762_abnormal_tongue_morphology2.41859680
23MP0001270_distended_abdomen2.31497668
24MP0002113_abnormal_skeleton_development2.28355681
25MP0005508_abnormal_skeleton_morphology2.26075590
26MP0008875_abnormal_xenobiotic_pharmacok2.22426228
27MP0003123_paternal_imprinting2.20740251
28MP0002896_abnormal_bone_mineralization2.19035846
29MP0001968_abnormal_touch/_nociception2.10698257
30MP0002837_dystrophic_cardiac_calcinosis2.09123216
31MP0002909_abnormal_adrenal_gland2.04204493
32MP0002735_abnormal_chemical_nociception2.01630411
33MP0005390_skeleton_phenotype2.01212609
34MP0004043_abnormal_pH_regulation1.98241599
35MP0002109_abnormal_limb_morphology1.96439136
36MP0006072_abnormal_retinal_apoptosis1.96056096
37MP0008872_abnormal_physiological_respon1.95572515
38MP0003011_delayed_dark_adaptation1.95160947
39MP0004147_increased_porphyrin_level1.91165880
40MP0001533_abnormal_skeleton_physiology1.91067433
41MP0002163_abnormal_gland_morphology1.90970429
42MP0009046_muscle_twitch1.89099214
43MP0003136_yellow_coat_color1.88585793
44MP0005275_abnormal_skin_tensile1.84096593
45MP0003283_abnormal_digestive_organ1.83807075
46MP0002108_abnormal_muscle_morphology1.81764809
47MP0000920_abnormal_myelination1.80992407
48MP0001986_abnormal_taste_sensitivity1.71483513
49MP0005084_abnormal_gallbladder_morpholo1.68838017
50MP0005253_abnormal_eye_physiology1.67670752
51MP0006292_abnormal_olfactory_placode1.65309970
52MP0004885_abnormal_endolymph1.61782084
53MP0004142_abnormal_muscle_tone1.61325625
54MP0002138_abnormal_hepatobiliary_system1.60016947
55MP0009384_cardiac_valve_regurgitation1.58392758
56MP0001485_abnormal_pinna_reflex1.56828524
57MP0009745_abnormal_behavioral_response1.56075023
58MP0005365_abnormal_bile_salt1.56054798
59MP0005085_abnormal_gallbladder_physiolo1.56050578
60MP0000749_muscle_degeneration1.55142568
61MP0001501_abnormal_sleep_pattern1.54743557
62MP0002653_abnormal_ependyma_morphology1.54191953
63MP0010386_abnormal_urinary_bladder1.49714471
64MP0004133_heterotaxia1.49417435
65MP0003795_abnormal_bone_structure1.45700816
66MP0003787_abnormal_imprinting1.44462664
67MP0003755_abnormal_palate_morphology1.44454831
68MP0002638_abnormal_pupillary_reflex1.44327213
69MP0002734_abnormal_mechanical_nocicepti1.44304520
70MP0003045_fibrosis1.42835583
71MP0002116_abnormal_craniofacial_bone1.42600836
72MP0000427_abnormal_hair_cycle1.42276704
73MP0003878_abnormal_ear_physiology1.41529845
74MP0005377_hearing/vestibular/ear_phenot1.41529845
75MP0000631_abnormal_neuroendocrine_gland1.38304401
76MP0001984_abnormal_olfaction1.37257539
77MP0001486_abnormal_startle_reflex1.37236868
78MP0000049_abnormal_middle_ear1.37226124
79MP0003656_abnormal_erythrocyte_physiolo1.35968459
80MP0000566_synostosis1.34702081
81MP0010329_abnormal_lipoprotein_level1.33987526
82MP0008004_abnormal_stomach_pH1.30819121
83MP0005174_abnormal_tail_pigmentation1.30174578
84MP0000462_abnormal_digestive_system1.27575646
85MP0000372_irregular_coat_pigmentation1.27369348
86MP0002160_abnormal_reproductive_system1.26132218
87MP0006276_abnormal_autonomic_nervous1.25693200
88MP0005389_reproductive_system_phenotype1.24476162
89MP0003315_abnormal_perineum_morphology1.24347675
90MP0002557_abnormal_social/conspecific_i1.22714324
91MP0002928_abnormal_bile_duct1.21849144
92MP0003252_abnormal_bile_duct1.18224073
93MP0002938_white_spotting1.18071777
94MP0005332_abnormal_amino_acid1.17752529
95MP0004019_abnormal_vitamin_homeostasis1.16728156
96MP0003880_abnormal_central_pattern1.16337956
97MP0005381_digestive/alimentary_phenotyp1.15923688
98MP0001963_abnormal_hearing_physiology1.13459119
99MP0005360_urolithiasis1.13281715
100MP0001529_abnormal_vocalization1.13032247
101MP0002572_abnormal_emotion/affect_behav1.11652199
102MP0008995_early_reproductive_senescence1.10923451
103MP0003718_maternal_effect1.10521506
104MP0002233_abnormal_nose_morphology1.09033623
105MP0005623_abnormal_meninges_morphology1.08444538
106MP0003195_calcinosis1.06452427
107MP0002751_abnormal_autonomic_nervous1.05286723
108MP0003937_abnormal_limbs/digits/tail_de1.04222966
109MP0002877_abnormal_melanocyte_morpholog1.03121833
110MP0002064_seizures1.03012589
111MP0005195_abnormal_posterior_eye1.02187844
112MP0004742_abnormal_vestibular_system1.02123485
113MP0002254_reproductive_system_inflammat1.01441349
114MP0009697_abnormal_copulation1.01271917
115MP0002733_abnormal_thermal_nociception1.00946110
116MP0000432_abnormal_head_morphology1.00788777
117MP0001188_hyperpigmentation1.00616339
118MP0002693_abnormal_pancreas_physiology0.98215827
119MP0001663_abnormal_digestive_system0.97474361
120MP0001919_abnormal_reproductive_system0.97079758
121MP0002736_abnormal_nociception_after0.95277786
122MP0001944_abnormal_pancreas_morphology0.93490677
123MP0005636_abnormal_mineral_homeostasis0.92892033
124MP0004924_abnormal_behavior0.92659809
125MP0005386_behavior/neurological_phenoty0.92659809
126MP0002277_abnormal_respiratory_mucosa0.92050017
127MP0005410_abnormal_fertilization0.91971838
128MP0001764_abnormal_homeostasis0.91255363
129MP0005167_abnormal_blood-brain_barrier0.90921313
130MP0001873_stomach_inflammation0.90657748
131MP0004381_abnormal_hair_follicle0.90523199
132MP0002139_abnormal_hepatobiliary_system0.90270669
133MP0001756_abnormal_urination0.89236526
134MP0005379_endocrine/exocrine_gland_phen0.87778253
135MP0000747_muscle_weakness0.87611388
136MP0001905_abnormal_dopamine_level0.87017300
137MP0001324_abnormal_eye_pigmentation0.86776497
138MP0001502_abnormal_circadian_rhythm0.86034584
139MP0005220_abnormal_exocrine_pancreas0.85164741
140MP0003698_abnormal_male_reproductive0.84799452
141MP0002229_neurodegeneration0.84570284
142MP0002998_abnormal_bone_remodeling0.81294570
143MP0000647_abnormal_sebaceous_gland0.81237152
144MP0003634_abnormal_glial_cell0.80883498
145MP0000383_abnormal_hair_follicle0.79350926
146MP0002114_abnormal_axial_skeleton0.79011042
147MP0002111_abnormal_tail_morphology0.78462229
148MP0002095_abnormal_skin_pigmentation0.78039255
149MP0003935_abnormal_craniofacial_develop0.77786724
150MP0001661_extended_life_span0.76030864
151MP0000538_abnormal_urinary_bladder0.75661218
152MP0001970_abnormal_pain_threshold0.75089153
153MP0000013_abnormal_adipose_tissue0.74832609
154MP0010030_abnormal_orbit_morphology0.70574957
155MP0002249_abnormal_larynx_morphology0.63966478
156MP0003121_genomic_imprinting0.63578842
157MP0003279_aneurysm0.63081982
158MP0002067_abnormal_sensory_capabilities0.62550329
159MP0005164_abnormal_response_to0.59268450
160MP0003436_decreased_susceptibility_to0.58791642
161MP0005646_abnormal_pituitary_gland0.58547865
162MP0004145_abnormal_muscle_electrophysio0.56717671
163MP0001943_abnormal_respiration0.56301260
164MP0000026_abnormal_inner_ear0.56067943
165MP0005645_abnormal_hypothalamus_physiol0.53786007
166MP0002168_other_aberrant_phenotype0.51589969
167MP0001958_emphysema0.50159617
168MP0004484_altered_response_of0.49571847
169MP0005023_abnormal_wound_healing0.49351390
170MP0001286_abnormal_eye_development0.48982494
171MP0003091_abnormal_cell_migration0.48559089
172MP0002272_abnormal_nervous_system0.47743988
173MP0003122_maternal_imprinting0.46344595
174MP0005171_absent_coat_pigmentation0.46152429
175MP0005408_hypopigmentation0.45151124
176MP0003385_abnormal_body_wall0.44221907
177MP0000343_altered_response_to0.43301457

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)8.99942141
2Epiphyseal dysplasia (HP:0002656)8.97933925
3Vitreoretinal degeneration (HP:0000655)7.14244133
4Ulnar claw (HP:0001178)6.62799607
5Small epiphyses (HP:0010585)6.51830629
6Abnormal tarsal ossification (HP:0008369)5.80689714
7Hypoplastic ischia (HP:0003175)5.70529683
8Segmental peripheral demyelination/remyelination (HP:0003481)5.59581184
9Cupped ribs (HP:0000887)5.54278457
10Flat capital femoral epiphysis (HP:0003370)5.47767655
11Delayed epiphyseal ossification (HP:0002663)5.24773068
12Abnormality of the ischium (HP:0003174)5.05988042
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.98688996
14Genu varum (HP:0002970)4.92228611
15Flat acetabular roof (HP:0003180)4.59544262
16Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.49424267
17Abnormality of femoral epiphyses (HP:0006499)4.49424267
18Impaired proprioception (HP:0010831)4.47971369
19Pancreatic cysts (HP:0001737)4.45575421
20Neonatal short-limb short stature (HP:0008921)4.24320022
21Abnormal foot bone ossification (HP:0010675)4.21440012
22Abnormality of the vertebral endplates (HP:0005106)4.14049248
23Absent epiphyses (HP:0010577)4.13764447
24Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.13764447
25Flattened epiphyses (HP:0003071)4.10683057
26Abnormality of midbrain morphology (HP:0002418)4.08510600
27Molar tooth sign on MRI (HP:0002419)4.08510600
28Metaphyseal cupping (HP:0003021)4.08382957
29Abnormality of the epiphysis of the femoral head (HP:0010574)4.07508813
30Pancreatic fibrosis (HP:0100732)4.04032430
31Congenital stationary night blindness (HP:0007642)4.01366019
32Arthropathy (HP:0003040)4.01227836
33Insidious onset (HP:0003587)3.97227545
34Termporal pattern (HP:0011008)3.97227545
35Short femoral neck (HP:0100864)3.96011485
36True hermaphroditism (HP:0010459)3.93028433
37Mild short stature (HP:0003502)3.86510412
38Abnormality of the femoral head (HP:0003368)3.77798422
39Metaphyseal dysplasia (HP:0100255)3.77007033
40Osteoarthritis (HP:0002758)3.74760784
41Irregular vertebral endplates (HP:0003301)3.63260161
42Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.58292806
43Type II lissencephaly (HP:0007260)3.55880003
44Metaphyseal irregularity (HP:0003025)3.49919754
45Upper limb muscle weakness (HP:0003484)3.34614192
46Nephronophthisis (HP:0000090)3.34243102
47Abnormality of the renal cortex (HP:0011035)3.23633061
48Action tremor (HP:0002345)3.22317394
49Medial flaring of the eyebrow (HP:0010747)3.01155896
50Abnormality of the renal medulla (HP:0100957)2.96158996
51Coxa vara (HP:0002812)2.94327833
52Abnormality of alanine metabolism (HP:0010916)2.93240322
53Hyperalaninemia (HP:0003348)2.93240322
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93240322
55Carpal bone hypoplasia (HP:0001498)2.92641574
56Abnormality of carpal bone ossification (HP:0006257)2.87775947
57Barrel-shaped chest (HP:0001552)2.86809136
58Protuberant abdomen (HP:0001538)2.85772637
59Limited hip movement (HP:0008800)2.80457401
60Platyspondyly (HP:0000926)2.79641841
61Abnormal vertebral ossification (HP:0100569)2.79129196
62Abnormality of the pubic bones (HP:0003172)2.78690611
63Beaking of vertebral bodies (HP:0004568)2.78248852
64Attenuation of retinal blood vessels (HP:0007843)2.78033601
65Thoracolumbar scoliosis (HP:0002944)2.77751137
66Abolished electroretinogram (ERG) (HP:0000550)2.77305030
67Abnormal rod and cone electroretinograms (HP:0008323)2.76372861
68Chronic hepatic failure (HP:0100626)2.73719379
69Aplasia/hypoplasia of the femur (HP:0005613)2.73575822
70Cystic liver disease (HP:0006706)2.72961827
71Increased CSF protein (HP:0002922)2.71944600
72Tubular atrophy (HP:0000092)2.68918627
73Abnormal drinking behavior (HP:0030082)2.66899050
74Polydipsia (HP:0001959)2.66899050
75Waddling gait (HP:0002515)2.66802152
76Pendular nystagmus (HP:0012043)2.63964562
77Abnormality of the proximal phalanges of the hand (HP:0009834)2.63191963
78Limited elbow extension (HP:0001377)2.60531380
79Hyperventilation (HP:0002883)2.59896684
80Ovoid vertebral bodies (HP:0003300)2.59880894
81Enlarged epiphyses (HP:0010580)2.58415954
82Cerebellar dysplasia (HP:0007033)2.56392117
83Large for gestational age (HP:0001520)2.55023932
84Hypothermia (HP:0002045)2.51478420
85Vertebral clefting (HP:0008428)2.50104826
86Decreased circulating renin level (HP:0003351)2.50044184
87Lumbar hyperlordosis (HP:0002938)2.48204887
88Abnormality of the phalanges of the 2nd finger (HP:0009541)2.47577927
89Abnormality of the vocal cords (HP:0008777)2.47238288
90Peripheral hypomyelination (HP:0007182)2.44928938
91Abnormality of incisor morphology (HP:0011063)2.44593182
92Renal cortical cysts (HP:0000803)2.44544330
93Steppage gait (HP:0003376)2.43133291
94Stillbirth (HP:0003826)2.42323912
95Bile duct proliferation (HP:0001408)2.41589326
96Abnormal biliary tract physiology (HP:0012439)2.41589326
97Acute necrotizing encephalopathy (HP:0006965)2.41165017
98Onion bulb formation (HP:0003383)2.38398029
99Methylmalonic acidemia (HP:0002912)2.38367244
100Lissencephaly (HP:0001339)2.34143750
101Ketoacidosis (HP:0001993)2.32906928
102Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.32111286
103Congenital, generalized hypertrichosis (HP:0004540)2.31329792
104Cervical subluxation (HP:0003308)2.31127963
105Gait imbalance (HP:0002141)2.30199942
106Increased corneal curvature (HP:0100692)2.29340819
107Keratoconus (HP:0000563)2.29340819
108Hip contracture (HP:0003273)2.27514076
109Decreased central vision (HP:0007663)2.27010746
110Progressive macrocephaly (HP:0004481)2.26798052
111Increased CSF lactate (HP:0002490)2.25464759
112Congenital primary aphakia (HP:0007707)2.25243203
113Hammertoe (HP:0001765)2.24807540
114Furrowed tongue (HP:0000221)2.24649496
115Abnormal hand bone ossification (HP:0010660)2.23231573
116Abnormality of the vitreous humor (HP:0004327)2.23173181
117Mitochondrial inheritance (HP:0001427)2.22506191
118Thin ribs (HP:0000883)2.22210481
119Sclerocornea (HP:0000647)2.20491278
120Hypoplasia of the odontoid process (HP:0003311)2.18892419
121Gaze-evoked nystagmus (HP:0000640)2.18662728
122Acute encephalopathy (HP:0006846)2.18119593
123Foot dorsiflexor weakness (HP:0009027)2.17588018
124Glossoptosis (HP:0000162)2.16711345
125Spinal cord compression (HP:0002176)2.16516365
126Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12821185
127Abnormal ossification of hand bones (HP:0005921)2.11750298
128Fibular hypoplasia (HP:0003038)2.11275502
129Hypoplastic pelvis (HP:0008839)2.10669004
130Ketosis (HP:0001946)2.10388988
131Polyuria (HP:0000103)2.10068924
132Nephrogenic diabetes insipidus (HP:0009806)2.10014996
133Abnormality of the lumbar spine (HP:0100712)2.09832345
134Aplasia/Hypoplasia of the tongue (HP:0010295)2.08697283
135Abnormality of the pons (HP:0007361)2.08147906
136Hypomagnesemia (HP:0002917)2.07599325
137Inability to walk (HP:0002540)2.06957824
138Male pseudohermaphroditism (HP:0000037)2.04278051
139Mesomelia (HP:0003027)2.04204740
140Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03682534
141Methylmalonic aciduria (HP:0012120)2.02933572
142Congenital sensorineural hearing impairment (HP:0008527)2.02533064
143Micromelia (HP:0002983)2.02450473
144Exostoses (HP:0100777)2.01808788
145Anencephaly (HP:0002323)2.01747630
146Hypoplastic ilia (HP:0000946)2.00723920
147Absent/shortened dynein arms (HP:0200106)2.00537764
148Dynein arm defect of respiratory motile cilia (HP:0012255)2.00537764
149Congenital hepatic fibrosis (HP:0002612)2.00267791
150Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.99567753
151Abnormal pupillary function (HP:0007686)1.99055924
152Aplasia/Hypoplasia of the spleen (HP:0010451)1.98579544
153Intestinal atresia (HP:0011100)1.98159252
154Abnormal mitochondria in muscle tissue (HP:0008316)1.96684267
155Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96633608
156Abnormality of the foot musculature (HP:0001436)1.94825085
157Genital tract atresia (HP:0001827)1.94375103
158Hypoplasia of the pons (HP:0012110)1.94001260
159Disproportionate short-trunk short stature (HP:0003521)1.93879487
160Absent frontal sinuses (HP:0002688)1.93308422
161Severe muscular hypotonia (HP:0006829)1.92300099
162Bony spicule pigmentary retinopathy (HP:0007737)1.91838207
163Relative macrocephaly (HP:0004482)1.90666370
164Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.90482578
165Optic nerve hypoplasia (HP:0000609)1.89848077
166Febrile seizures (HP:0002373)1.89692481
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88615305
168Hepatic necrosis (HP:0002605)1.87327017
169Progressive cerebellar ataxia (HP:0002073)1.86339825
170Abnormal respiratory epithelium morphology (HP:0012253)1.86279660
171Abnormal respiratory motile cilium morphology (HP:0005938)1.86279660
172Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86180031
173Vertebral hypoplasia (HP:0008417)1.86180031
174Vaginal atresia (HP:0000148)1.85695307
175Long clavicles (HP:0000890)1.85407254
176Progressive inability to walk (HP:0002505)1.85272820
177Abnormality of macular pigmentation (HP:0008002)1.84827408
178Aplasia/hypoplasia of the uterus (HP:0008684)1.83943524
179Tachypnea (HP:0002789)1.83573884
180Abnormality of vitamin B metabolism (HP:0004340)1.82303566
181Optic disc pallor (HP:0000543)1.81701325
182Chorioretinal atrophy (HP:0000533)1.81435119
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81379398
184Short middle phalanx of finger (HP:0005819)1.80837266
185Abnormal sex determination (HP:0012244)1.80388823
186Sex reversal (HP:0012245)1.80388823
187Postaxial foot polydactyly (HP:0001830)1.79942303
188Fair hair (HP:0002286)1.79721825
189Asplenia (HP:0001746)1.78151276
190Abnormal urine output (HP:0012590)1.77884065
191Pachygyria (HP:0001302)1.77631482
192Hyperglycinuria (HP:0003108)1.76793809
193Hemiparesis (HP:0001269)1.76590459
194Broad-based gait (HP:0002136)1.76419399
195Glycosuria (HP:0003076)1.76333445
196Abnormality of urine glucose concentration (HP:0011016)1.76333445
197Abnormality of the labia minora (HP:0012880)1.74823064
198Hepatocellular necrosis (HP:0001404)1.73707256
199Abnormality of renin-angiotensin system (HP:0000847)1.73414779
200Absent speech (HP:0001344)1.73067225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.03815893
2DDR25.55899368
3MAP3K35.45316616
4STK38L4.92440504
5STK244.03695343
6NME13.92965411
7MST43.20661215
8PRKG23.14233329
9MAP4K23.13711461
10GRK12.82154621
11ACVR1B2.61361906
12WNK32.26834452
13LATS12.26194324
14IRAK22.22676124
15STK392.16305518
16ERBB32.10682686
17PLK22.09871745
18TAOK32.07357954
19NUAK11.91764995
20IRAK11.88635596
21PIM21.87940116
22INSRR1.85904091
23OXSR11.74208096
24DAPK21.71767844
25TXK1.68189306
26TLK11.63114871
27MKNK21.62705376
28WNK41.58615973
29MAPK131.55127658
30EPHA31.52405285
31MAP3K41.49510695
32STK31.49068055
33BCR1.44153245
34TNIK1.40680822
35BRSK21.37183038
36BUB11.37054164
37BMPR1B1.36808029
38TRPM71.35141129
39PAK31.33464835
40MARK31.28434857
41DYRK1A1.28401631
42NEK61.21788082
43LIMK11.20911834
44PNCK1.20422751
45EIF2AK31.18292811
46EPHA21.14217922
47DYRK21.11671574
48PBK1.11575542
49ADRBK11.10770847
50FGFR21.07278230
51CDK81.06664553
52NLK1.04585673
53PRKCG1.01214884
54NME20.97999863
55LMTK20.95928321
56ARAF0.93042104
57LATS20.91033285
58EPHB10.90707173
59TIE10.90023372
60TGFBR10.88885645
61NTRK30.87925477
62CAMKK20.84832341
63FGFR30.84811611
64CSNK1G20.84518100
65PLK30.83075953
66MELK0.80480738
67CSNK1G30.79069846
68MAPK150.77902753
69MUSK0.77115093
70ROCK10.76027499
71MAP2K60.75444702
72MAPKAPK30.73439194
73AKT30.73359352
74BCKDK0.71598424
75CSNK1A1L0.71265038
76TRIM280.70744113
77MARK10.70653726
78PIK3CA0.70364947
79STK160.70358463
80BMPR20.70138025
81VRK10.68810857
82MAP2K70.68095213
83PRKD30.67924522
84ERBB40.67441397
85MAPKAPK50.62837427
86CDK90.62509497
87GSK3A0.62459738
88PTK2B0.62007819
89ZAK0.57854622
90PRKCI0.56599174
91MAP3K140.54527254
92IRAK30.53664119
93BRSK10.53117470
94CAMK2A0.52844447
95WEE10.51498646
96PIM10.50531634
97MET0.50113733
98SIK30.49108389
99EIF2AK10.48539796
100NEK90.48221347
101SGK2230.47472672
102SGK4940.47472672
103NTRK20.45128867
104YES10.44066084
105STK110.43883236
106EIF2AK20.42381093
107RPS6KA50.41865577
108MKNK10.41300971
109CSK0.40786788
110MAPK40.40771555
111EPHA40.40266548
112TEC0.40091047
113ADRBK20.40021299
114PRKAA20.39903211
115MAP3K20.39242271
116CSNK1D0.38962182
117PRKCE0.38635680
118VRK20.38451563
119PRKCA0.37472171
120PRKAA10.37281526
121PRKCZ0.36305433
122PLK40.35849995
123PTK20.34554022
124GRK70.32171952
125MAPK100.31996955
126CAMK10.31240684
127PKN10.30719711
128CAMK2D0.30128722
129UHMK10.30082806
130PRKCQ0.28805186
131ERBB20.28511232
132PLK10.28101459
133MAPK70.27699638
134RET0.27389993
135ITK0.26932069
136SIK20.26344241
137IKBKB0.26204603
138KSR10.26106450
139FER0.25117922
140PHKG20.25099638
141PHKG10.25099638
142CHUK0.24642037
143PDK20.24204761
144PINK10.23790131
145PRKACA0.23714877
146PRKG10.23496791
147WNK10.22763892
148IGF1R0.21630217
149MAPK120.20771049
150EPHB20.19875116
151MAPK30.19850503
152PRKACG0.19158113
153RPS6KB10.18832805
154CASK0.18787100
155SGK20.17712321
156ROCK20.17599975
157MAP2K10.17197592
158CSNK1G10.16944284
159SIK10.16314561
160FGFR10.15360112
161CSNK1A10.14808614

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.30821465
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005325.84033727
3Protein digestion and absorption_Homo sapiens_hsa049745.17615087
4Steroid biosynthesis_Homo sapiens_hsa001003.40154949
5Sphingolipid metabolism_Homo sapiens_hsa006003.14861629
6Protein export_Homo sapiens_hsa030603.09098736
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.83764146
8Butanoate metabolism_Homo sapiens_hsa006502.55041440
9Phototransduction_Homo sapiens_hsa047442.49743548
10Nitrogen metabolism_Homo sapiens_hsa009102.48286087
11Sulfur metabolism_Homo sapiens_hsa009202.46493186
12Linoleic acid metabolism_Homo sapiens_hsa005912.43492147
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36651411
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34824757
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33038843
16Oxidative phosphorylation_Homo sapiens_hsa001902.22234786
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.17128506
18Focal adhesion_Homo sapiens_hsa045102.12766405
19Tryptophan metabolism_Homo sapiens_hsa003801.94724361
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91214861
21Caffeine metabolism_Homo sapiens_hsa002321.83552689
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.75814678
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64175900
24Olfactory transduction_Homo sapiens_hsa047401.62463213
25Nicotine addiction_Homo sapiens_hsa050331.61252067
26Propanoate metabolism_Homo sapiens_hsa006401.60850110
27TGF-beta signaling pathway_Homo sapiens_hsa043501.54219507
28Malaria_Homo sapiens_hsa051441.50338354
29Parkinsons disease_Homo sapiens_hsa050121.47697108
30Hedgehog signaling pathway_Homo sapiens_hsa043401.47533509
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46631335
32Peroxisome_Homo sapiens_hsa041461.46242883
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43238904
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.39907136
35Chemical carcinogenesis_Homo sapiens_hsa052041.37156350
36Fat digestion and absorption_Homo sapiens_hsa049751.36774540
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.36734002
38Homologous recombination_Homo sapiens_hsa034401.32829649
39Folate biosynthesis_Homo sapiens_hsa007901.31398484
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29607339
41Retinol metabolism_Homo sapiens_hsa008301.27107727
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26563431
43ABC transporters_Homo sapiens_hsa020101.26048374
44Fanconi anemia pathway_Homo sapiens_hsa034601.24980665
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24934507
46One carbon pool by folate_Homo sapiens_hsa006701.20037678
47Basal transcription factors_Homo sapiens_hsa030221.19955534
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19886940
49Starch and sucrose metabolism_Homo sapiens_hsa005001.14334984
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13439994
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13081392
52Collecting duct acid secretion_Homo sapiens_hsa049661.09822790
53Taste transduction_Homo sapiens_hsa047421.09437642
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07379166
55Hippo signaling pathway_Homo sapiens_hsa043901.03864151
56Histidine metabolism_Homo sapiens_hsa003401.03055349
57beta-Alanine metabolism_Homo sapiens_hsa004101.01799652
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98758718
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97515710
60Alzheimers disease_Homo sapiens_hsa050100.97352738
61Huntingtons disease_Homo sapiens_hsa050160.95178168
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94218415
63RNA degradation_Homo sapiens_hsa030180.92679498
64Mineral absorption_Homo sapiens_hsa049780.91656002
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90153327
66Arginine and proline metabolism_Homo sapiens_hsa003300.89643414
67Autoimmune thyroid disease_Homo sapiens_hsa053200.88275667
68Dorso-ventral axis formation_Homo sapiens_hsa043200.88227633
69Morphine addiction_Homo sapiens_hsa050320.87964862
70Vibrio cholerae infection_Homo sapiens_hsa051100.86834479
71Cardiac muscle contraction_Homo sapiens_hsa042600.86817360
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83789714
73Fatty acid degradation_Homo sapiens_hsa000710.83419264
74Long-term depression_Homo sapiens_hsa047300.81248261
75Circadian rhythm_Homo sapiens_hsa047100.80040526
76N-Glycan biosynthesis_Homo sapiens_hsa005100.78606127
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76979481
78Phagosome_Homo sapiens_hsa041450.76881838
79Metabolic pathways_Homo sapiens_hsa011000.76507161
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.76342422
81Glycerolipid metabolism_Homo sapiens_hsa005610.75385813
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74343394
83Axon guidance_Homo sapiens_hsa043600.70869156
84GABAergic synapse_Homo sapiens_hsa047270.68871672
85Glutamatergic synapse_Homo sapiens_hsa047240.68546680
86Dilated cardiomyopathy_Homo sapiens_hsa054140.67924906
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66721706
88Thyroid cancer_Homo sapiens_hsa052160.65545335
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.64875703
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63910961
91Fatty acid biosynthesis_Homo sapiens_hsa000610.63425804
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63133275
93Hematopoietic cell lineage_Homo sapiens_hsa046400.62494878
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61995672
95Fatty acid metabolism_Homo sapiens_hsa012120.61830091
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60823587
97Arachidonic acid metabolism_Homo sapiens_hsa005900.59934041
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.59329952
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58836649
100Proteasome_Homo sapiens_hsa030500.57439214
101Purine metabolism_Homo sapiens_hsa002300.57333455
102Non-homologous end-joining_Homo sapiens_hsa034500.57010191
103Salivary secretion_Homo sapiens_hsa049700.56446845
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.55598418
105Basal cell carcinoma_Homo sapiens_hsa052170.55124229
106RNA polymerase_Homo sapiens_hsa030200.54984793
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54024003
108Asthma_Homo sapiens_hsa053100.53622705
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52905360
110Proteoglycans in cancer_Homo sapiens_hsa052050.52399604
111Ovarian steroidogenesis_Homo sapiens_hsa049130.51914328
112Tight junction_Homo sapiens_hsa045300.51698482
113Ether lipid metabolism_Homo sapiens_hsa005650.51663828
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50395717
115Small cell lung cancer_Homo sapiens_hsa052220.49897540
116Viral myocarditis_Homo sapiens_hsa054160.49764684
117Pancreatic secretion_Homo sapiens_hsa049720.47059443
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.46656685
119Thyroid hormone synthesis_Homo sapiens_hsa049180.46208065
120Selenocompound metabolism_Homo sapiens_hsa004500.46172043
121Allograft rejection_Homo sapiens_hsa053300.45631437
122Amoebiasis_Homo sapiens_hsa051460.44210133
123Prostate cancer_Homo sapiens_hsa052150.41993418
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41487077
125Complement and coagulation cascades_Homo sapiens_hsa046100.40940314
126Bile secretion_Homo sapiens_hsa049760.40274803
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39009790
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38471083
129T cell receptor signaling pathway_Homo sapiens_hsa046600.37434155
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36286508
131Cocaine addiction_Homo sapiens_hsa050300.35696223
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35597318
133Pyrimidine metabolism_Homo sapiens_hsa002400.34396209
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34260702
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33742733
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33455732
137Serotonergic synapse_Homo sapiens_hsa047260.33124342
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32956356
139Regulation of autophagy_Homo sapiens_hsa041400.32844369
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.32719863
141Toxoplasmosis_Homo sapiens_hsa051450.32681895
142Cholinergic synapse_Homo sapiens_hsa047250.32523089
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31038293
144Adherens junction_Homo sapiens_hsa045200.30861891
145Melanogenesis_Homo sapiens_hsa049160.30755019
146Melanoma_Homo sapiens_hsa052180.30417429
147Ras signaling pathway_Homo sapiens_hsa040140.30259322
148Cell cycle_Homo sapiens_hsa041100.29670556
149Insulin secretion_Homo sapiens_hsa049110.28945093
150Fatty acid elongation_Homo sapiens_hsa000620.27453110
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.26937736
152Vitamin B6 metabolism_Homo sapiens_hsa007500.26912102
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26264364
154Circadian entrainment_Homo sapiens_hsa047130.25851177
155Gap junction_Homo sapiens_hsa045400.25255713
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24464550
157Vitamin digestion and absorption_Homo sapiens_hsa049770.24242231
158Pathways in cancer_Homo sapiens_hsa052000.23633479
159Wnt signaling pathway_Homo sapiens_hsa043100.23302650
160Bladder cancer_Homo sapiens_hsa052190.22664218
161Other glycan degradation_Homo sapiens_hsa005110.22120524
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19037167
163Hepatitis C_Homo sapiens_hsa051600.18645667
164Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18630384

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