NCOA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.26486397
2locomotory exploration behavior (GO:0035641)4.80329150
3vocalization behavior (GO:0071625)4.72731820
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.65709001
5synaptic vesicle maturation (GO:0016188)4.52562305
6synaptic vesicle exocytosis (GO:0016079)4.41553152
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39979880
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.38537446
9regulation of synaptic vesicle exocytosis (GO:2000300)4.33886090
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33230747
11glutamate secretion (GO:0014047)4.20901383
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19944441
13regulation of glutamate receptor signaling pathway (GO:1900449)4.18994010
14neuron cell-cell adhesion (GO:0007158)4.10095787
15protein localization to synapse (GO:0035418)3.99540264
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.97075087
17neurotransmitter-gated ion channel clustering (GO:0072578)3.96190061
18regulation of synaptic vesicle transport (GO:1902803)3.89477498
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88281250
20negative regulation of cell killing (GO:0031342)3.88281250
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76735655
22glutamate receptor signaling pathway (GO:0007215)3.69702037
23regulation of neuronal synaptic plasticity (GO:0048168)3.66547319
24synaptic transmission, glutamatergic (GO:0035249)3.64784659
25positive regulation of gamma-delta T cell activation (GO:0046645)3.61721905
26neurotransmitter secretion (GO:0007269)3.61511484
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59757463
28exploration behavior (GO:0035640)3.58137344
29gamma-aminobutyric acid transport (GO:0015812)3.55183242
30neuronal action potential propagation (GO:0019227)3.54694250
31regulation of B cell receptor signaling pathway (GO:0050855)3.47357401
32neuron-neuron synaptic transmission (GO:0007270)3.46290068
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43866490
34activated T cell proliferation (GO:0050798)3.42641921
35cellular potassium ion homeostasis (GO:0030007)3.40188434
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39993496
37presynaptic membrane assembly (GO:0097105)3.38733016
38microglial cell activation (GO:0001774)3.38674499
39long-term memory (GO:0007616)3.37923232
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37904224
41long-term synaptic potentiation (GO:0060291)3.37702494
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33661690
43regulation of postsynaptic membrane potential (GO:0060078)3.26056174
44regulation of synapse structural plasticity (GO:0051823)3.24382892
45cerebellar Purkinje cell differentiation (GO:0021702)3.22150239
46activation of protein kinase A activity (GO:0034199)3.21326072
47synaptic vesicle endocytosis (GO:0048488)3.18870326
48presynaptic membrane organization (GO:0097090)3.17410829
49macrophage activation involved in immune response (GO:0002281)3.16739204
50innervation (GO:0060384)3.14428877
51regulation of synaptic plasticity (GO:0048167)3.14071280
52layer formation in cerebral cortex (GO:0021819)3.13915165
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11107448
54postsynaptic membrane organization (GO:0001941)3.06222198
55positive regulation of membrane potential (GO:0045838)3.06059957
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05574502
57positive regulation by symbiont of host defense response (GO:0052509)3.05472945
58modulation by symbiont of host defense response (GO:0052031)3.05472945
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05472945
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05472945
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.05472945
62modulation by symbiont of host immune response (GO:0052553)3.05472945
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.01848413
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.01378300
65striatum development (GO:0021756)3.01094912
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00920511
67detection of molecule of bacterial origin (GO:0032490)3.00554962
68startle response (GO:0001964)2.99367545
69regulation of neurotransmitter secretion (GO:0046928)2.96427685
70detection of calcium ion (GO:0005513)2.95986808
71negative regulation of neurotransmitter secretion (GO:0046929)2.95051746
72neuron recognition (GO:0008038)2.93540059
73positive regulation of synapse maturation (GO:0090129)2.91846670
74neurotransmitter transport (GO:0006836)2.91786700
75transmission of nerve impulse (GO:0019226)2.90240116
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89247401
77proline transport (GO:0015824)2.89038796
78membrane depolarization during action potential (GO:0086010)2.87432551
79cellular response to interleukin-15 (GO:0071350)2.86345382
80sodium ion export (GO:0071436)2.86032151
81cellular extravasation (GO:0045123)2.85740455
82dendritic spine morphogenesis (GO:0060997)2.85341973
83cell communication by electrical coupling (GO:0010644)2.84941885
84response to interleukin-15 (GO:0070672)2.83452023
85negative regulation of T cell mediated immunity (GO:0002710)2.82206012
86cerebellar granule cell differentiation (GO:0021707)2.82110449
87dendrite morphogenesis (GO:0048813)2.82000248
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80934891
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79604295
90response to auditory stimulus (GO:0010996)2.79288822
91negative regulation of neurotransmitter transport (GO:0051589)2.78284133
92regulation of vesicle fusion (GO:0031338)2.78167249
93auditory behavior (GO:0031223)2.77878839
94membrane depolarization (GO:0051899)2.77554495
95regulation of gamma-delta T cell activation (GO:0046643)2.77004188
96chemosensory behavior (GO:0007635)2.76640393
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76227814
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.75961578
99positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.75937322
100macrophage activation (GO:0042116)2.75493054
101regulation of dendritic spine morphogenesis (GO:0061001)2.73728451
102synapse assembly (GO:0007416)2.73435003
103regulation of neurotransmitter transport (GO:0051588)2.72308374
104membrane hyperpolarization (GO:0060081)2.72107580
105positive regulation of Rap GTPase activity (GO:0032854)2.71949925
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70709985
107positive regulation of synaptic transmission (GO:0050806)2.70663458
108axonal fasciculation (GO:0007413)2.70509281
109response to histamine (GO:0034776)2.69954895
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69872987
111learning (GO:0007612)2.68315287
112positive regulation of neurotransmitter transport (GO:0051590)2.67566019
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67528149
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66543567
115nerve growth factor signaling pathway (GO:0038180)2.65260212
116behavioral fear response (GO:0001662)2.64992361
117behavioral defense response (GO:0002209)2.64992361
118regulation of voltage-gated calcium channel activity (GO:1901385)2.64314335
119regulation of Rap GTPase activity (GO:0032317)2.64197503
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.63264929
121regulation of neurotransmitter levels (GO:0001505)2.62824904
122negative regulation of dendrite morphogenesis (GO:0050774)2.62740501
123growth hormone receptor signaling pathway (GO:0060396)2.62686056
124negative regulation of lymphocyte mediated immunity (GO:0002707)2.61567985
125regulation of ARF protein signal transduction (GO:0032012)2.61031812
126long term synaptic depression (GO:0060292)2.60785536
127regulation of gamma-delta T cell differentiation (GO:0045586)2.59454244
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.59291338
129vesicle transport along microtubule (GO:0047496)2.59112293
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.58691894
131negative regulation of dendrite development (GO:2000171)2.58588445
132synaptic transmission (GO:0007268)2.58228657
133interkinetic nuclear migration (GO:0022027)2.58220040
134positive regulation of cellular amide metabolic process (GO:0034250)2.58122315
135regulation of synaptic transmission (GO:0050804)2.57956756
136positive regulation of neurotransmitter secretion (GO:0001956)2.57892936
137neutrophil mediated immunity (GO:0002446)2.57715890
138regulation of beta-amyloid formation (GO:1902003)2.56649488
139positive T cell selection (GO:0043368)2.54120141
140positive regulation of mast cell activation (GO:0033005)2.52601534
141neutrophil activation involved in immune response (GO:0002283)2.52335802
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51167421
143germinal center formation (GO:0002467)2.48708596
144B cell receptor signaling pathway (GO:0050853)2.48227984
145negative regulation of T-helper cell differentiation (GO:0045623)2.46703602
146negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46703602
147detection of other organism (GO:0098543)2.45046318
148histone H3-K9 demethylation (GO:0033169)2.43471159
149histone H3-K4 trimethylation (GO:0080182)2.42665150
150myeloid leukocyte mediated immunity (GO:0002444)2.41991929
151cellular response to epinephrine stimulus (GO:0071872)2.40468842
152cellular response to growth hormone stimulus (GO:0071378)2.39305189
153detection of external biotic stimulus (GO:0098581)2.37123515
154regulation of germinal center formation (GO:0002634)2.36279891
155neutrophil activation (GO:0042119)2.34840451
156L-amino acid import (GO:0043092)2.34269112
157antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29377875
158negative thymic T cell selection (GO:0045060)2.28612998
159establishment of protein localization to Golgi (GO:0072600)2.27520497
160cell differentiation in hindbrain (GO:0021533)2.27509273
161potassium ion import (GO:0010107)2.27507335
162negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.27205902
163regulation of interferon-beta biosynthetic process (GO:0045357)2.26130359
164negative T cell selection (GO:0043383)2.25577548
165response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25081388
166response to host immune response (GO:0052572)2.25081388
167histone H3-K36 demethylation (GO:0070544)2.23865892
168retrograde transport, vesicle recycling within Golgi (GO:0000301)2.23806275
169interferon-gamma production (GO:0032609)2.22030876
170positive thymic T cell selection (GO:0045059)2.20992223
171antigen processing and presentation of endogenous antigen (GO:0019883)2.20243104
172protein targeting to Golgi (GO:0000042)2.19931381
173piRNA metabolic process (GO:0034587)2.19009057
174negative regulation of erythrocyte differentiation (GO:0045647)2.18131988
175myeloid cell activation involved in immune response (GO:0002275)2.16114884
176detection of biotic stimulus (GO:0009595)2.14592125
177leukocyte migration involved in inflammatory response (GO:0002523)2.14112643
178nucleus localization (GO:0051647)2.13896322
179negative regulation of leukocyte mediated immunity (GO:0002704)2.13161461
180negative regulation of cAMP-mediated signaling (GO:0043951)2.10992255
181response to epinephrine (GO:0071871)2.09099807
182positive regulation of mast cell degranulation (GO:0043306)2.08962649
183positive regulation of mast cell activation involved in immune response (GO:0033008)2.08962649
184regulation of mast cell activation (GO:0033003)2.08361863
185negative regulation of interleukin-12 production (GO:0032695)2.07951443
186granulocyte activation (GO:0036230)2.07860547
187detection of bacterium (GO:0016045)2.05419262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25793281
2GBX2_23144817_ChIP-Seq_PC3_Human3.68215923
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73063916
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69042076
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66835548
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58363215
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55560614
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35224938
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35224938
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30295266
11DROSHA_22980978_ChIP-Seq_HELA_Human2.26889169
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23874646
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19745284
14REST_21632747_ChIP-Seq_MESCs_Mouse2.18375363
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17158966
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16829030
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13967353
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.09353490
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.02190246
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.01472352
21RUNX_20019798_ChIP-Seq_JUKART_Human1.98692330
22* RARB_27405468_Chip-Seq_BRAIN_Mouse1.98592442
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.87308797
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.86865938
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.85820958
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85621770
27AR_21572438_ChIP-Seq_LNCaP_Human1.79973520
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.79446083
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77391742
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77158171
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.76579284
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75639061
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71667847
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.63841088
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59990944
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59754328
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59639142
38TAF15_26573619_Chip-Seq_HEK293_Human1.57387923
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56860138
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56342224
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54240658
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.53598801
43P300_19829295_ChIP-Seq_ESCs_Human1.53523351
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52646653
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.50352853
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48586826
47AHR_22903824_ChIP-Seq_MCF-7_Human1.44920964
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.43146220
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39839305
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38729502
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.38334192
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36894210
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.36173261
54VDR_24787735_ChIP-Seq_THP-1_Human1.35543665
55STAT3_23295773_ChIP-Seq_U87_Human1.35520029
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34825529
57AR_25329375_ChIP-Seq_VCAP_Human1.34709769
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34645485
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34490224
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33689753
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30257690
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.29487095
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28859327
64SCL_19346495_ChIP-Seq_HPC-7_Human1.28718268
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28179484
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27619750
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27317014
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26899126
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25158665
70* AR_19668381_ChIP-Seq_PC3_Human1.22848995
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22054505
72TCF4_23295773_ChIP-Seq_U87_Human1.21749394
73* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20911412
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20904078
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20862700
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20371559
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20255930
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19753877
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19537955
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19182122
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17992731
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.16781775
83IGF1R_20145208_ChIP-Seq_DFB_Human1.16730066
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16691512
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14202475
86BCAT_22108803_ChIP-Seq_LS180_Human1.12465220
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.11957160
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10508674
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10342100
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10342100
91RXR_22108803_ChIP-Seq_LS180_Human1.09611999
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09334112
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07870776
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.06623562
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06511021
96RUNX2_22187159_ChIP-Seq_PCA_Human1.06079837
97SPI1_23127762_ChIP-Seq_K562_Human1.05942017
98ER_23166858_ChIP-Seq_MCF-7_Human1.05726542
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05123063
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04433469
101RNF2_27304074_Chip-Seq_NSC_Mouse1.03604169
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03015862
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.02728858
104* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02595332
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02512502
106TP53_16413492_ChIP-PET_HCT116_Human1.02292076
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00927452
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00812003
109* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99624669
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98412669
111* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98143503
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97769212
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97611955
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.97184441
115VDR_22108803_ChIP-Seq_LS180_Human0.96958579
116* FLI1_21867929_ChIP-Seq_TH2_Mouse0.95930983
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95780745
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.95442539
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94865141
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94682130
121FUS_26573619_Chip-Seq_HEK293_Human0.93684068
122* TP53_18474530_ChIP-ChIP_U2OS_Human0.93369166
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92593245
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92544595
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91691535
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91138374
127KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90445059
128P53_22387025_ChIP-Seq_ESCs_Mouse0.89876454
129RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89875806
130* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89811401
131* KDM2B_26808549_Chip-Seq_REH_Human0.88797603
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88335509
133GATA3_27048872_Chip-Seq_THYMUS_Human0.87961741
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.87713572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.74345624
2MP0003724_increased_susceptibility_to3.93338476
3MP0003635_abnormal_synaptic_transmissio3.79457892
4MP0003880_abnormal_central_pattern3.74256737
5MP0004270_analgesia3.55881482
6MP0009745_abnormal_behavioral_response3.08102825
7MP0001984_abnormal_olfaction3.05749413
8* MP0002063_abnormal_learning/memory/cond3.05140604
9MP0008877_abnormal_DNA_methylation2.92080826
10MP0009046_muscle_twitch2.81703378
11MP0002064_seizures2.78802634
12MP0003303_peritoneal_inflammation2.64025545
13MP0009780_abnormal_chondrocyte_physiolo2.63447874
14MP0002572_abnormal_emotion/affect_behav2.61659110
15MP0001486_abnormal_startle_reflex2.54932323
16MP0002734_abnormal_mechanical_nocicepti2.50340206
17MP0002822_catalepsy2.50192793
18MP0002272_abnormal_nervous_system2.47008991
19MP0001968_abnormal_touch/_nociception2.31361628
20MP0005423_abnormal_somatic_nervous2.23538889
21MP0005646_abnormal_pituitary_gland2.18057731
22MP0001501_abnormal_sleep_pattern2.17840757
23MP0005645_abnormal_hypothalamus_physiol2.10999286
24MP0005551_abnormal_eye_electrophysiolog1.99414460
25MP0002909_abnormal_adrenal_gland1.99411324
26MP0001835_abnormal_antigen_presentation1.96401579
27MP0008569_lethality_at_weaning1.95416584
28MP0002735_abnormal_chemical_nociception1.95370640
29MP0003787_abnormal_imprinting1.93126854
30MP0002067_abnormal_sensory_capabilities1.91226577
31MP0005671_abnormal_response_to1.84590783
32MP0005394_taste/olfaction_phenotype1.83903423
33MP0005499_abnormal_olfactory_system1.83903423
34MP0002557_abnormal_social/conspecific_i1.82653379
35MP0002184_abnormal_innervation1.81027070
36MP0003436_decreased_susceptibility_to1.75273905
37MP0003656_abnormal_erythrocyte_physiolo1.74676411
38MP0000778_abnormal_nervous_system1.74317619
39MP0001800_abnormal_humoral_immune1.71380990
40MP0004885_abnormal_endolymph1.70144998
41MP0002736_abnormal_nociception_after1.69677623
42MP0001440_abnormal_grooming_behavior1.68203584
43MP0001970_abnormal_pain_threshold1.67094691
44MP0004858_abnormal_nervous_system1.66012519
45MP0001502_abnormal_circadian_rhythm1.65775591
46MP0002733_abnormal_thermal_nociception1.59831758
47MP0003763_abnormal_thymus_physiology1.53404213
48MP0000569_abnormal_digit_pigmentation1.53093467
49MP0005000_abnormal_immune_tolerance1.52728793
50MP0004924_abnormal_behavior1.52166169
51MP0005386_behavior/neurological_phenoty1.52166169
52MP0004811_abnormal_neuron_physiology1.51426863
53MP0003879_abnormal_hair_cell1.48498988
54* MP0002882_abnormal_neuron_morphology1.46422008
55MP0001790_abnormal_immune_system1.46049508
56MP0005387_immune_system_phenotype1.46049508
57MP0003045_fibrosis1.37037369
58MP0002723_abnormal_immune_serum1.36048714
59MP0002419_abnormal_innate_immunity1.35545071
60MP0001188_hyperpigmentation1.35165335
61MP0006276_abnormal_autonomic_nervous1.34919121
62MP0003172_abnormal_lysosome_physiology1.33719881
63MP0000955_abnormal_spinal_cord1.33564815
64MP0008789_abnormal_olfactory_epithelium1.32845749
65MP0005167_abnormal_blood-brain_barrier1.30270052
66MP0003300_gastrointestinal_ulcer1.28139517
67MP0004381_abnormal_hair_follicle1.27449142
68MP0002420_abnormal_adaptive_immunity1.26853700
69MP0010386_abnormal_urinary_bladder1.24119983
70MP0003828_pulmonary_edema1.23784513
71MP0003633_abnormal_nervous_system1.23329542
72MP0001819_abnormal_immune_cell1.23296917
73MP0003329_amyloid_beta_deposits1.22223906
74MP0005025_abnormal_response_to1.22050727
75MP0000685_abnormal_immune_system1.20644287
76MP0000920_abnormal_myelination1.20187540
77* MP0002066_abnormal_motor_capabilities/c1.19598887
78MP0006072_abnormal_retinal_apoptosis1.16590912
79MP0002638_abnormal_pupillary_reflex1.15898969
80MP0003866_abnormal_defecation1.15067868
81MP0005174_abnormal_tail_pigmentation1.14955056
82MP0002229_neurodegeneration1.14166096
83MP0002653_abnormal_ependyma_morphology1.12890138
84MP0006082_CNS_inflammation1.12450603
85MP0002452_abnormal_antigen_presenting1.10954449
86MP0002837_dystrophic_cardiac_calcinosis1.09721099
87MP0005464_abnormal_platelet_physiology1.08162761
88MP0008004_abnormal_stomach_pH1.07579806
89MP0004085_abnormal_heartbeat1.07487355
90MP0004145_abnormal_muscle_electrophysio1.06416603
91MP0002277_abnormal_respiratory_mucosa1.05326479
92MP0001177_atelectasis1.04179270
93MP0000015_abnormal_ear_pigmentation1.04048335
94MP0001851_eye_inflammation1.03354183
95MP0005253_abnormal_eye_physiology1.03323538
96MP0002405_respiratory_system_inflammati1.01226488
97* MP0002152_abnormal_brain_morphology1.00587783
98MP0003631_nervous_system_phenotype0.99736113
99MP0000013_abnormal_adipose_tissue0.98081483
100MP0002752_abnormal_somatic_nervous0.96651364
101MP0005310_abnormal_salivary_gland0.96570700
102MP0004484_altered_response_of0.95092153
103MP0002398_abnormal_bone_marrow0.93832679
104MP0000631_abnormal_neuroendocrine_gland0.91837773
105MP0002876_abnormal_thyroid_physiology0.91651581
106MP0001963_abnormal_hearing_physiology0.90920475
107MP0002069_abnormal_eating/drinking_beha0.90024730
108MP0009785_altered_susceptibility_to0.89770537
109MP0005535_abnormal_body_temperature0.86824872
110MP0000716_abnormal_immune_system0.86280195
111MP0003011_delayed_dark_adaptation0.86075066
112MP0004215_abnormal_myocardial_fiber0.84951249
113MP0000465_gastrointestinal_hemorrhage0.84559822
114MP0002090_abnormal_vision0.84282818
115MP0008260_abnormal_autophagy0.83552878
116MP0000751_myopathy0.83536544
117MP0002332_abnormal_exercise_endurance0.83252873
118MP0002971_abnormal_brown_adipose0.82985248
119MP0001485_abnormal_pinna_reflex0.82885565
120MP0004742_abnormal_vestibular_system0.82774432
121MP0003634_abnormal_glial_cell0.81715406
122MP0002148_abnormal_hypersensitivity_rea0.81474170
123MP0004883_abnormal_blood_vessel0.81357607
124MP0001533_abnormal_skeleton_physiology0.80904341
125MP0004043_abnormal_pH_regulation0.79375497
126MP0009115_abnormal_fat_cell0.79355447
127MP0003690_abnormal_glial_cell0.78883991
128MP0004142_abnormal_muscle_tone0.76306342
129MP0002138_abnormal_hepatobiliary_system0.76152451
130MP0004130_abnormal_muscle_cell0.75558436
131MP0000703_abnormal_thymus_morphology0.75238030
132MP0001905_abnormal_dopamine_level0.72723153
133MP0008961_abnormal_basal_metabolism0.69971082
134MP0003183_abnormal_peptide_metabolism0.69753262
135MP0003632_abnormal_nervous_system0.68477225
136MP0005171_absent_coat_pigmentation0.67684259
137MP0008874_decreased_physiological_sensi0.67137073
138MP0003646_muscle_fatigue0.66066044
139MP0005195_abnormal_posterior_eye0.65334677
140MP0005409_darkened_coat_color0.64977767
141MP0003122_maternal_imprinting0.64087971
142MP0002877_abnormal_melanocyte_morpholog0.63507488
143MP0000026_abnormal_inner_ear0.63366494
144MP0001986_abnormal_taste_sensitivity0.63347737
145MP0000003_abnormal_adipose_tissue0.62404011
146MP0001299_abnormal_eye_distance/0.59623406
147MP0005187_abnormal_penis_morphology0.58867106
148MP0003137_abnormal_impulse_conducting0.58286828
149MP0002009_preneoplasia0.55861781
150MP0004510_myositis0.53980961
151MP0006292_abnormal_olfactory_placode0.53763354

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.11618142
2Febrile seizures (HP:0002373)5.13123731
3Focal seizures (HP:0007359)4.95151357
4Epileptic encephalopathy (HP:0200134)4.64865109
5Myokymia (HP:0002411)4.56972797
6Atonic seizures (HP:0010819)4.45848154
7Visual hallucinations (HP:0002367)4.05318996
8Progressive cerebellar ataxia (HP:0002073)4.00868044
9Hyperventilation (HP:0002883)3.95029688
10Absence seizures (HP:0002121)3.75234899
11Optic neuritis (HP:0100653)3.62872068
12Retrobulbar optic neuritis (HP:0100654)3.62872068
13Eczematoid dermatitis (HP:0000976)3.54149148
14Action tremor (HP:0002345)3.49274814
15Dialeptic seizures (HP:0011146)3.45253002
16Gaze-evoked nystagmus (HP:0000640)3.29119332
17Generalized tonic-clonic seizures (HP:0002069)3.27215554
18Orchitis (HP:0100796)3.27118086
19Broad-based gait (HP:0002136)3.22594813
20Myositis (HP:0100614)3.21564011
21Recurrent bacterial skin infections (HP:0005406)3.10816309
22Genetic anticipation (HP:0003743)3.00620086
23Difficulty running (HP:0009046)2.96936811
24Gastrointestinal infarctions (HP:0005244)2.92337044
25Dysdiadochokinesis (HP:0002075)2.86050023
26Stomatitis (HP:0010280)2.83415460
27Spontaneous hematomas (HP:0007420)2.83246940
28Keratoconjunctivitis sicca (HP:0001097)2.82169097
29Truncal ataxia (HP:0002078)2.80943162
30Central scotoma (HP:0000603)2.69192564
31Drooling (HP:0002307)2.66482388
32Excessive salivation (HP:0003781)2.66482388
33Abnormality of macular pigmentation (HP:0008002)2.66310645
34Gait imbalance (HP:0002141)2.66134685
35Keratoconjunctivitis (HP:0001096)2.64838451
36Recurrent abscess formation (HP:0002722)2.63446276
37Muscle fiber splitting (HP:0003555)2.59406127
38Poor eye contact (HP:0000817)2.53868065
39Absent speech (HP:0001344)2.53633505
40Hypochromic microcytic anemia (HP:0004840)2.53233629
41Abnormal eating behavior (HP:0100738)2.52929238
42Depression (HP:0000716)2.51587796
43T lymphocytopenia (HP:0005403)2.51550225
44Dysmetric saccades (HP:0000641)2.51463494
45Urinary bladder sphincter dysfunction (HP:0002839)2.47990587
46Supranuclear gaze palsy (HP:0000605)2.47259032
47Impaired social interactions (HP:0000735)2.47044118
48Abnormal social behavior (HP:0012433)2.47044118
49Congenital stationary night blindness (HP:0007642)2.46723431
50Abnormality of T cell number (HP:0011839)2.46660944
51Bony spicule pigmentary retinopathy (HP:0007737)2.43240614
52Epileptiform EEG discharges (HP:0011182)2.42099642
53Anxiety (HP:0000739)2.40893410
54Truncal obesity (HP:0001956)2.40362229
55Congenital primary aphakia (HP:0007707)2.38474901
56Medial flaring of the eyebrow (HP:0010747)2.36512871
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35265678
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.35077096
59Impaired vibration sensation in the lower limbs (HP:0002166)2.33909957
60Stereotypic behavior (HP:0000733)2.33334942
61Impaired smooth pursuit (HP:0007772)2.32224351
62Dysmetria (HP:0001310)2.32028341
63Ankle clonus (HP:0011448)2.30780521
64Recurrent fungal infections (HP:0002841)2.30592816
65Prolonged bleeding time (HP:0003010)2.29725515
66EEG with generalized epileptiform discharges (HP:0011198)2.29466847
67Amblyopia (HP:0000646)2.28392154
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.28152984
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28152984
70Postural instability (HP:0002172)2.27232966
71Megalencephaly (HP:0001355)2.25569586
72Chest pain (HP:0100749)2.24863301
73Scanning speech (HP:0002168)2.23950861
74Blue irides (HP:0000635)2.23445000
75Leukocytosis (HP:0001974)2.21798882
76Nephrogenic diabetes insipidus (HP:0009806)2.21686125
77Abnormality of macrophages (HP:0004311)2.21326959
78Stomach cancer (HP:0012126)2.20087363
79Pulmonary infiltrates (HP:0002113)2.18729380
80Encephalitis (HP:0002383)2.18466823
81Hemoptysis (HP:0002105)2.18411225
82Recurrent gram-negative bacterial infections (HP:0005420)2.17272664
83Aplasia involving bones of the extremities (HP:0009825)2.17070303
84Aplasia involving bones of the upper limbs (HP:0009823)2.17070303
85Aplasia of the phalanges of the hand (HP:0009802)2.17070303
86Prolonged QT interval (HP:0001657)2.16910460
87Gingivitis (HP:0000230)2.14798397
88Hypsarrhythmia (HP:0002521)2.14542150
89Protruding tongue (HP:0010808)2.10766849
90Gingival bleeding (HP:0000225)2.10764671
91Vasculitis (HP:0002633)2.10687012
92Neoplasm of the heart (HP:0100544)2.09196932
93Vertigo (HP:0002321)2.08384632
94Distal arthrogryposis (HP:0005684)2.07624352
95Meningitis (HP:0001287)2.04694782
96Hyporeflexia of lower limbs (HP:0002600)2.04292152
97Hemiparesis (HP:0001269)2.03569420
98Diplopia (HP:0000651)2.03360780
99Abnormality of binocular vision (HP:0011514)2.03360780
100Retinal dysplasia (HP:0007973)2.02735967
101Abnormality of the corticospinal tract (HP:0002492)2.01544733
102Abnormality of salivation (HP:0100755)2.00144662
103Progressive inability to walk (HP:0002505)1.99906302
104Aqueductal stenosis (HP:0002410)1.98681390
105Elevated erythrocyte sedimentation rate (HP:0003565)1.98176427
106Recurrent skin infections (HP:0001581)1.96219995
107Amyotrophic lateral sclerosis (HP:0007354)1.95861365
108Hemiplegia (HP:0002301)1.95762293
109Genital tract atresia (HP:0001827)1.95744121
110Dyschromatopsia (HP:0007641)1.95608357
111Abnormal rod and cone electroretinograms (HP:0008323)1.94212392
112Abnormality of ocular smooth pursuit (HP:0000617)1.93832265
113Abnormality of the left ventricular outflow tract (HP:0011103)1.92774421
114Subaortic stenosis (HP:0001682)1.92774421
115Widely spaced teeth (HP:0000687)1.91980099
116Mediastinal lymphadenopathy (HP:0100721)1.90953347
117Pulmonary embolism (HP:0002204)1.90623715
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90481887
119Abnormal EKG (HP:0003115)1.90413034
120Recurrent cutaneous fungal infections (HP:0011370)1.90149193
121Chronic mucocutaneous candidiasis (HP:0002728)1.90149193
122Scotoma (HP:0000575)1.89286086
123Fetal akinesia sequence (HP:0001989)1.87838051
124Arterial thrombosis (HP:0004420)1.87805015
125Pheochromocytoma (HP:0002666)1.87331728
126Syncope (HP:0001279)1.87232994
127Abnormality of the fingertips (HP:0001211)1.87113677
128Osteomalacia (HP:0002749)1.86985295
129Poor coordination (HP:0002370)1.86125326
130Vaginal atresia (HP:0000148)1.85588895
131Neoplasm of the tracheobronchial system (HP:0100552)1.85479062
132Abnormality of incisor morphology (HP:0011063)1.85436925
133Bradycardia (HP:0001662)1.84779389
134Papillary thyroid carcinoma (HP:0002895)1.84705205
135Torticollis (HP:0000473)1.82880384
136Agitation (HP:0000713)1.82543467
137Intention tremor (HP:0002080)1.82523041
138Obstructive sleep apnea (HP:0002870)1.81355692
139Bradykinesia (HP:0002067)1.81179949
140Abnormal hair whorl (HP:0010721)1.80249010
141Increased IgE level (HP:0003212)1.80203648
142Impaired vibratory sensation (HP:0002495)1.79721947
143Ventricular fibrillation (HP:0001663)1.79469236
144Hyperkalemia (HP:0002153)1.79458684
145Polyphagia (HP:0002591)1.78126128
146Specific learning disability (HP:0001328)1.76627930
147Peritonitis (HP:0002586)1.75769897
148Thickened helices (HP:0000391)1.75740575
149Choroideremia (HP:0001139)1.75391754
150Spastic gait (HP:0002064)1.74710328
151Inability to walk (HP:0002540)1.72565342
152Abnormality of eosinophils (HP:0001879)1.72304495
153Inappropriate behavior (HP:0000719)1.70410218
154Anosmia (HP:0000458)1.68746218
155Eosinophilia (HP:0001880)1.68652086
156Focal dystonia (HP:0004373)1.68385625
157Papilledema (HP:0001085)1.67986674
158Status epilepticus (HP:0002133)1.67861074
159Peripheral hypomyelination (HP:0007182)1.67757055
160Absent eyebrow (HP:0002223)1.67170808
161Thyroid carcinoma (HP:0002890)1.66808944
162Macroorchidism (HP:0000053)1.63537267
163Spinal canal stenosis (HP:0003416)1.60864050
164Narrow nasal bridge (HP:0000446)1.60347697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.82331310
2EPHA43.25218546
3CASK2.76470154
4MAP3K42.75777866
5MAP2K72.61039539
6MAP3K92.45743482
7MARK12.27765175
8PRPF4B2.17684236
9SGK22.15991587
10PRKD32.12139670
11MINK12.08004764
12DAPK21.91418920
13AKT31.91391336
14TAOK31.86145273
15RIPK41.83069295
16NTRK21.80399426
17SGK31.78215485
18SGK2231.78111328
19SGK4941.78111328
20BLK1.66183427
21TXK1.64045159
22MAP2K41.61682581
23MAPK131.60304713
24MAP3K121.59839445
25PHKG21.59036356
26PHKG11.59036356
27EPHA31.56629989
28PAK61.52243290
29INSRR1.46897523
30CSK1.46350382
31PLK21.45380717
32SIK21.42113841
33MAP4K11.41064172
34BMPR21.40437769
35STK381.37328238
36CAMKK11.36231253
37CAMK1G1.34580908
38CDK51.33617413
39KSR11.32571718
40MAP3K21.31698955
41PRKCH1.25704241
42SYK1.23201279
43IRAK41.22984867
44SIK31.22797444
45JAK11.21973965
46EPHB11.21771168
47PIK3CG1.21449790
48NLK1.20275703
49OBSCN1.19532938
50IRAK11.18761566
51DAPK11.17368103
52PRKCG1.16598813
53NTRK11.15000093
54IKBKE1.11130579
55KSR21.10268704
56TNIK1.09579286
57ZAP701.06709795
58JAK21.06019261
59MAP2K31.05605460
60YES11.04683589
61GRK51.02539151
62ACVR1B1.02156833
63IRAK21.01896329
64ERBB31.01539120
65CDK190.99930484
66TYK20.99215675
67DYRK1A0.97213026
68FES0.96519430
69BTK0.95543379
70PINK10.94609622
71HCK0.92196725
72SGK10.91618915
73CAMK2A0.91173139
74FGR0.89835007
75TNK20.87691989
76GRK60.82876433
77CAMK10.81849900
78PRKCE0.81801602
79STK110.78491664
80MUSK0.77781958
81LMTK20.75831673
82CAMKK20.75205641
83DMPK0.74568728
84PNCK0.74372614
85TEC0.73536769
86CAMK2B0.72252112
87ITK0.71214978
88MARK30.71086088
89FRK0.70770844
90MAP3K130.70371468
91CAMK1D0.69771762
92MARK20.68824896
93LCK0.68488952
94TYRO30.67151185
95OXSR10.66626845
96CAMK40.65839637
97HIPK20.65787229
98LYN0.65552216
99JAK30.65479831
100BMPR1B0.64185989
101FER0.62898751
102PAK30.62805502
103PDGFRB0.62772052
104MAP3K70.62384859
105WNK10.61394829
106CDC42BPA0.60269422
107RAF10.57995110
108CSF1R0.57979764
109CAMK2D0.57433905
110NEK60.56833233
111CDK30.56421902
112PDK10.56027517
113PRKCQ0.55758552
114RIPK10.55459818
115PRKCZ0.55433589
116RET0.53792337
117CSNK1G20.53744916
118RPS6KA20.51556569
119RPS6KA30.51059216
120UHMK10.50964006
121MAP3K10.50730021
122PTK2B0.49494416
123FGFR20.49422396
124ARAF0.49316185
125PDPK10.49021047
126FGFR30.48398522
127MAPK100.45623757
128CAMK2G0.45409058
129TAOK10.44643381
130MAPK120.43681437
131MAPK70.43025677
132RPS6KB10.41968686
133MAP3K60.41319058
134CDK180.40331920
135FYN0.37465328
136GRK10.37268057
137PRKCB0.36909695
138BCR0.35676607
139PRKACA0.34971580

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.07597141
2Olfactory transduction_Homo sapiens_hsa047403.06133516
3Synaptic vesicle cycle_Homo sapiens_hsa047212.66180858
4Circadian entrainment_Homo sapiens_hsa047132.56151142
5GABAergic synapse_Homo sapiens_hsa047272.48974198
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46027952
7Morphine addiction_Homo sapiens_hsa050322.41959380
8Long-term potentiation_Homo sapiens_hsa047202.40811545
9Phototransduction_Homo sapiens_hsa047442.36247736
10Glutamatergic synapse_Homo sapiens_hsa047242.34813153
11Insulin secretion_Homo sapiens_hsa049112.17085451
12Amphetamine addiction_Homo sapiens_hsa050312.13237717
13Dopaminergic synapse_Homo sapiens_hsa047281.94534740
14Salivary secretion_Homo sapiens_hsa049701.91560233
15Cholinergic synapse_Homo sapiens_hsa047251.85199280
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79319619
17Gastric acid secretion_Homo sapiens_hsa049711.76648041
18Taste transduction_Homo sapiens_hsa047421.72452108
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70967129
20Osteoclast differentiation_Homo sapiens_hsa043801.63431456
21Renin secretion_Homo sapiens_hsa049241.61754252
22B cell receptor signaling pathway_Homo sapiens_hsa046621.55343358
23Serotonergic synapse_Homo sapiens_hsa047261.49588680
24Calcium signaling pathway_Homo sapiens_hsa040201.49083254
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48777824
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46536244
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45780517
28Leishmaniasis_Homo sapiens_hsa051401.45306432
29Long-term depression_Homo sapiens_hsa047301.45161750
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43483794
31Oxytocin signaling pathway_Homo sapiens_hsa049211.43465679
32Cocaine addiction_Homo sapiens_hsa050301.42476660
33T cell receptor signaling pathway_Homo sapiens_hsa046601.41005017
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34346231
35GnRH signaling pathway_Homo sapiens_hsa049121.33317220
36cAMP signaling pathway_Homo sapiens_hsa040241.33069991
37Type II diabetes mellitus_Homo sapiens_hsa049301.32383832
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29313637
39Collecting duct acid secretion_Homo sapiens_hsa049661.23275338
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22314936
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20763942
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18954207
43Platelet activation_Homo sapiens_hsa046111.18179514
44Staphylococcus aureus infection_Homo sapiens_hsa051501.17216281
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15353331
46Tuberculosis_Homo sapiens_hsa051521.11040807
47Graft-versus-host disease_Homo sapiens_hsa053321.08151720
48Estrogen signaling pathway_Homo sapiens_hsa049151.08117071
49Glioma_Homo sapiens_hsa052141.07441568
50Gap junction_Homo sapiens_hsa045401.06543865
51Melanogenesis_Homo sapiens_hsa049161.04747237
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04222512
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.03436468
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99015680
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98298574
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98253279
57ErbB signaling pathway_Homo sapiens_hsa040120.98007531
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96012002
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94374039
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94292506
61Allograft rejection_Homo sapiens_hsa053300.93951401
62Circadian rhythm_Homo sapiens_hsa047100.92168807
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.91515360
64Pancreatic secretion_Homo sapiens_hsa049720.90601730
65Dorso-ventral axis formation_Homo sapiens_hsa043200.89458636
66Acute myeloid leukemia_Homo sapiens_hsa052210.88140883
67Autoimmune thyroid disease_Homo sapiens_hsa053200.88106384
68Dilated cardiomyopathy_Homo sapiens_hsa054140.87321343
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85699248
70Measles_Homo sapiens_hsa051620.85489751
71Axon guidance_Homo sapiens_hsa043600.84040822
72Vibrio cholerae infection_Homo sapiens_hsa051100.82309136
73Thyroid hormone synthesis_Homo sapiens_hsa049180.81704402
74Toxoplasmosis_Homo sapiens_hsa051450.81071365
75Malaria_Homo sapiens_hsa051440.77744893
76Nitrogen metabolism_Homo sapiens_hsa009100.76584269
77Regulation of autophagy_Homo sapiens_hsa041400.76083506
78MAPK signaling pathway_Homo sapiens_hsa040100.76009348
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75928413
80Glucagon signaling pathway_Homo sapiens_hsa049220.73748081
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.72841261
82TNF signaling pathway_Homo sapiens_hsa046680.70609046
83Influenza A_Homo sapiens_hsa051640.70205074
84* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69929096
85Choline metabolism in cancer_Homo sapiens_hsa052310.67983712
86Endometrial cancer_Homo sapiens_hsa052130.67894182
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67552507
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.67504846
89Pancreatic cancer_Homo sapiens_hsa052120.67180821
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66815999
91Notch signaling pathway_Homo sapiens_hsa043300.66743154
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66561506
93Inositol phosphate metabolism_Homo sapiens_hsa005620.66427185
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.66298778
95Type I diabetes mellitus_Homo sapiens_hsa049400.66015802
96Hematopoietic cell lineage_Homo sapiens_hsa046400.64902630
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64216396
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.63281471
99Insulin resistance_Homo sapiens_hsa049310.62766827
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62279162
101Ras signaling pathway_Homo sapiens_hsa040140.62195704
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62082551
103Hepatitis C_Homo sapiens_hsa051600.62050244
104Cardiac muscle contraction_Homo sapiens_hsa042600.61756720
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.61171022
106Chronic myeloid leukemia_Homo sapiens_hsa052200.60757228
107Rap1 signaling pathway_Homo sapiens_hsa040150.60283484
108Primary immunodeficiency_Homo sapiens_hsa053400.59897592
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54467417
110mTOR signaling pathway_Homo sapiens_hsa041500.53310604
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53096185
112Ovarian steroidogenesis_Homo sapiens_hsa049130.50392059
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50243270
114Wnt signaling pathway_Homo sapiens_hsa043100.49974959
115Chemokine signaling pathway_Homo sapiens_hsa040620.49624594
116Insulin signaling pathway_Homo sapiens_hsa049100.49407935
117Non-small cell lung cancer_Homo sapiens_hsa052230.49311640
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47380830
119Fatty acid biosynthesis_Homo sapiens_hsa000610.47245143
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44559799
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44472704
122Oocyte meiosis_Homo sapiens_hsa041140.43240885
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41854327
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.41838046
125Prolactin signaling pathway_Homo sapiens_hsa049170.41213508
126Renal cell carcinoma_Homo sapiens_hsa052110.41194511
127VEGF signaling pathway_Homo sapiens_hsa043700.40601935
128Bile secretion_Homo sapiens_hsa049760.37985483
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37203313
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35189898
131Melanoma_Homo sapiens_hsa052180.34902000
132Endocytosis_Homo sapiens_hsa041440.33795392
133Alcoholism_Homo sapiens_hsa050340.32395417
134FoxO signaling pathway_Homo sapiens_hsa040680.32377694
135African trypanosomiasis_Homo sapiens_hsa051430.31863619
136Colorectal cancer_Homo sapiens_hsa052100.30926261

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