NCOA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter secretion (GO:0046929)4.52017408
2neuron remodeling (GO:0016322)4.47742042
3histone H3-K36 demethylation (GO:0070544)4.46748963
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.10202302
5histone H3-K9 demethylation (GO:0033169)4.05538751
6regulation of mitotic spindle organization (GO:0060236)3.87620642
7cellular response to ethanol (GO:0071361)3.80494013
8histone H3-K4 trimethylation (GO:0080182)3.72512503
9regulation of transforming growth factor beta2 production (GO:0032909)3.68808294
10detection of molecule of bacterial origin (GO:0032490)3.68628604
11regulation of B cell receptor signaling pathway (GO:0050855)3.57405516
12cytoplasmic mRNA processing body assembly (GO:0033962)3.52392922
13positive thymic T cell selection (GO:0045059)3.42645218
14positive T cell selection (GO:0043368)3.40562389
15negative T cell selection (GO:0043383)3.35566565
16negative thymic T cell selection (GO:0045060)3.33688449
17macrophage activation involved in immune response (GO:0002281)3.32618815
18negative regulation of neurotransmitter transport (GO:0051589)3.31939117
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30319891
20histone H3-K4 methylation (GO:0051568)3.27517641
21positive regulation of gamma-delta T cell activation (GO:0046645)3.24490840
22nuclear pore complex assembly (GO:0051292)3.16461359
23thymic T cell selection (GO:0045061)3.14814034
24cellular extravasation (GO:0045123)3.14337736
25regulation of ARF protein signal transduction (GO:0032012)3.11357430
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.10318430
27regulation of gamma-delta T cell differentiation (GO:0045586)3.08507403
28T cell selection (GO:0045058)3.08081258
29embryonic process involved in female pregnancy (GO:0060136)3.07685676
30histone lysine demethylation (GO:0070076)3.03896822
31positive regulation by symbiont of host defense response (GO:0052509)3.03444604
32modulation by symbiont of host defense response (GO:0052031)3.03444604
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03444604
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03444604
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.03444604
36modulation by symbiont of host immune response (GO:0052553)3.03444604
37growth hormone receptor signaling pathway (GO:0060396)3.01567679
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99283472
39genitalia morphogenesis (GO:0035112)2.98765913
40germinal center formation (GO:0002467)2.97402634
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94572329
42negative regulation of cell killing (GO:0031342)2.94572329
43positive regulation of histone deacetylation (GO:0031065)2.93333809
44regulation of short-term neuronal synaptic plasticity (GO:0048172)2.92804280
45definitive hemopoiesis (GO:0060216)2.92198085
46mRNA modification (GO:0016556)2.91383425
47positive regulation of Rap GTPase activity (GO:0032854)2.90784580
48histone demethylation (GO:0016577)2.90346900
49detection of external biotic stimulus (GO:0098581)2.88255666
50polyol transport (GO:0015791)2.85012359
51detection of other organism (GO:0098543)2.82561743
52regulation of gamma-delta T cell activation (GO:0046643)2.82233967
53mitotic sister chromatid cohesion (GO:0007064)2.77815164
54cerebellar Purkinje cell differentiation (GO:0021702)2.76766171
55regulation of Rap GTPase activity (GO:0032317)2.73810032
56substrate-dependent cell migration (GO:0006929)2.73805554
57B cell receptor signaling pathway (GO:0050853)2.73315290
58hepatocyte apoptotic process (GO:0097284)2.72600342
59sodium ion export (GO:0071436)2.72562779
60neutrophil mediated immunity (GO:0002446)2.70657561
61myeloid leukocyte mediated immunity (GO:0002444)2.67479301
62intestinal epithelial cell development (GO:0060576)2.67342095
63protein dealkylation (GO:0008214)2.63431731
64protein demethylation (GO:0006482)2.63431731
65histone lysine methylation (GO:0034968)2.62924846
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.62041571
67regulation of spindle organization (GO:0090224)2.61562416
68regulation of clathrin-mediated endocytosis (GO:2000369)2.60802340
69regulation of RNA export from nucleus (GO:0046831)2.60749150
70embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59964740
71positive regulation of gene expression, epigenetic (GO:0045815)2.59763290
72nuclear pore organization (GO:0006999)2.59393896
73protein K48-linked deubiquitination (GO:0071108)2.59033017
74macrophage activation (GO:0042116)2.58167040
75peptidyl-lysine trimethylation (GO:0018023)2.57666608
76synaptic vesicle maturation (GO:0016188)2.56262545
77microglial cell activation (GO:0001774)2.55272987
78cellular response to growth hormone stimulus (GO:0071378)2.54817387
79regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.54340109
80positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.54340109
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53804822
82peptidyl-threonine phosphorylation (GO:0018107)2.53526110
83corticosteroid receptor signaling pathway (GO:0031958)2.52813902
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52140981
85positive regulation of granulocyte differentiation (GO:0030854)2.52014393
86regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.49008747
87positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.49008747
88negative regulation of immunoglobulin mediated immune response (GO:0002890)2.48726596
89negative regulation of B cell mediated immunity (GO:0002713)2.48726596
90glucocorticoid receptor signaling pathway (GO:0042921)2.47527977
91detection of biotic stimulus (GO:0009595)2.46479359
92leukocyte migration involved in inflammatory response (GO:0002523)2.46206026
93retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44341165
94positive regulation of T cell differentiation in thymus (GO:0033089)2.43800732
95protein export from nucleus (GO:0006611)2.43727443
96protein targeting to vacuole (GO:0006623)2.43236340
97protein targeting to lysosome (GO:0006622)2.43236340
98establishment of protein localization to vacuole (GO:0072666)2.43236340
99regulation of histone deacetylation (GO:0031063)2.41874856
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.41531791
101negative regulation of T-helper cell differentiation (GO:0045623)2.41398668
102negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.41398668
103peptidyl-threonine modification (GO:0018210)2.39937820
104detection of bacterium (GO:0016045)2.39746722
105embryonic hemopoiesis (GO:0035162)2.38573673
106histone H4-K16 acetylation (GO:0043984)2.37096755
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.36401940
108interkinetic nuclear migration (GO:0022027)2.36350792
109positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.36225794
110CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.36181456
111negative regulation of T cell mediated immunity (GO:0002710)2.35505645
112protein K11-linked deubiquitination (GO:0035871)2.35332150
113response to host immune response (GO:0052572)2.31648629
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.31648629
115phospholipid translocation (GO:0045332)2.30681126
116lipid translocation (GO:0034204)2.30681126
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.30625766
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29983291
119response to host (GO:0075136)2.29983291
120response to host defenses (GO:0052200)2.29983291
121negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.29746407
122negative regulation of translation, ncRNA-mediated (GO:0040033)2.29746407
123regulation of translation, ncRNA-mediated (GO:0045974)2.29746407
124pre-miRNA processing (GO:0031054)2.27220657
125megakaryocyte development (GO:0035855)2.27191796
126retinal cone cell development (GO:0046549)2.26736966
127positive regulation of mRNA catabolic process (GO:0061014)2.26039303
128response to interleukin-15 (GO:0070672)2.25526362
129regulation of NFAT protein import into nucleus (GO:0051532)2.25490298
130nerve growth factor signaling pathway (GO:0038180)2.23210263
131peptidyl-lysine dimethylation (GO:0018027)2.21849250
132locomotory exploration behavior (GO:0035641)2.21437357
133synaptic vesicle docking involved in exocytosis (GO:0016081)2.21145050
134NLS-bearing protein import into nucleus (GO:0006607)2.19964238
135positive regulation of CREB transcription factor activity (GO:0032793)2.19715888
136establishment of nucleus localization (GO:0040023)2.18221611
137protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.15024744
138nucleus localization (GO:0051647)2.14341351
139regulation of mRNA catabolic process (GO:0061013)2.13463212
140dicarboxylic acid biosynthetic process (GO:0043650)2.13396465
141macroautophagy (GO:0016236)2.11382808
142presynaptic membrane organization (GO:0097090)2.11223018
143protein targeting to Golgi (GO:0000042)2.09919566
144regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.08946899
145regulation of protein deacetylation (GO:0090311)2.07890066
146embryonic camera-type eye morphogenesis (GO:0048596)2.06504699
147stress granule assembly (GO:0034063)2.06009528
148establishment of protein localization to Golgi (GO:0072600)2.05480346
149cellular potassium ion homeostasis (GO:0030007)2.05451835
150regulation of T cell tolerance induction (GO:0002664)2.04536024
151regulation of protein polyubiquitination (GO:1902914)2.04437791
152peptidyl-lysine methylation (GO:0018022)2.03287045
153negative regulation of circadian rhythm (GO:0042754)2.01562711
154regulation of ARF GTPase activity (GO:0032312)2.00346013
155positive regulation of fatty acid beta-oxidation (GO:0032000)1.99424409
156cellular response to interleukin-15 (GO:0071350)1.99241536
157antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.98063079
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.98063079
159gonadal mesoderm development (GO:0007506)1.97936149
160potassium ion import (GO:0010107)1.95339505
161relaxation of cardiac muscle (GO:0055119)1.94551945
162cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.92961443
163positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.92502862
164histone H3-K9 methylation (GO:0051567)1.92239971
165histone methylation (GO:0016571)1.91265482
166CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)1.89638969
167T-helper cell differentiation (GO:0042093)1.89638969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34060783
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16492066
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.50162090
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39891631
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18198738
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11685290
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09009194
8RUNX_20019798_ChIP-Seq_JUKART_Human2.03352214
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02645580
10EZH2_22144423_ChIP-Seq_EOC_Human2.00843292
11DROSHA_22980978_ChIP-Seq_HELA_Human1.91819508
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89555776
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83411215
14AR_21572438_ChIP-Seq_LNCaP_Human1.82760440
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82076440
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74551526
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.72042723
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67575369
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64273490
20* TCF7_22412390_ChIP-Seq_EML_Mouse1.61457229
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60832290
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60189995
23TAF15_26573619_Chip-Seq_HEK293_Human1.59652744
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57658667
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54226097
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53826517
27* GBX2_23144817_ChIP-Seq_PC3_Human1.53791685
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51236080
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.49118219
30* KDM2B_26808549_Chip-Seq_DND41_Human1.48582186
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.47890793
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46812420
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45721508
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41043808
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40215983
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38643405
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.38393638
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.31671971
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30912390
40* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30796333
41SMAD4_21799915_ChIP-Seq_A2780_Human1.30692793
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30292709
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28393871
44* KDM2B_26808549_Chip-Seq_K562_Human1.28273674
45MYC_22102868_ChIP-Seq_BL_Human1.26239357
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26008851
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24693018
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24304301
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23881992
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23665638
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22407106
52STAT3_23295773_ChIP-Seq_U87_Human1.21597138
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21363614
54TP53_16413492_ChIP-PET_HCT116_Human1.21356118
55* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20499845
56* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18988013
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.18930663
58* ARNT_22903824_ChIP-Seq_MCF-7_Human1.18638175
59* AHR_22903824_ChIP-Seq_MCF-7_Human1.18582376
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17641018
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17627672
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.17401710
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17386070
64* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16707303
65SCL_19346495_ChIP-Seq_HPC-7_Human1.16391222
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.15573954
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15240439
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.14826752
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14009882
70* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13963268
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13826712
72* AR_19668381_ChIP-Seq_PC3_Human1.13507359
73* PU_27001747_Chip-Seq_BMDM_Mouse1.12911898
74* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12743032
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12229439
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.12095482
77* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11755484
78GATA3_27048872_Chip-Seq_THYMUS_Human1.10226025
79* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10024781
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09988115
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09723559
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08691051
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08691051
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.08542997
85* TCF4_23295773_ChIP-Seq_U87_Human1.08145955
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07655535
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07300546
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07133174
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06516979
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06084302
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06084302
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.06013573
93GATA1_22025678_ChIP-Seq_K562_Human1.05448298
94IGF1R_20145208_ChIP-Seq_DFB_Human1.05186356
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04586756
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04258668
97* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04113441
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03653297
99EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03653297
100* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02586678
101* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02567833
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00897381
103* LXR_22158963_ChIP-Seq_LIVER_Mouse1.00589453
104* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00469446
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.99557726
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99282836
107* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99213162
108* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98988497
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98690155
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98631512
111PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98438218
112BCAT_22108803_ChIP-Seq_LS180_Human0.98180945
113* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97797340
114VDR_24763502_ChIP-Seq_THP-1_Human0.97407038
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97353773
116SPI1_23127762_ChIP-Seq_K562_Human0.97172568
117* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97139781
118* NFE2_27457419_Chip-Seq_LIVER_Mouse0.96935264
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96660163
120* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96073627
121* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95612945
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95548179
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.95403485
124VDR_24787735_ChIP-Seq_THP-1_Human0.95376473
125MYB_26560356_Chip-Seq_TH1_Human0.94506412
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94285408
127* FLI1_27457419_Chip-Seq_LIVER_Mouse0.92836882
128* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92611148
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92551297
130* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92390228
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.92349775
132GATA2_19941826_ChIP-Seq_K562_Human0.91967373
133* AR_25329375_ChIP-Seq_VCAP_Human0.91179590
134UTX_26944678_Chip-Seq_JUKART_Human0.90733468
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.90532148
136MYB_26560356_Chip-Seq_TH2_Human0.90429516
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89740762
138* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89501633
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89191634
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88926080
141MAF_26560356_Chip-Seq_TH1_Human0.88785989
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88186120
143RXR_22108803_ChIP-Seq_LS180_Human0.86851818
144GATA1_19941826_ChIP-Seq_K562_Human0.86639197
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86633510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.19925537
2MP0003303_peritoneal_inflammation3.88616806
3MP0003300_gastrointestinal_ulcer3.82720135
4MP0008057_abnormal_DNA_replication3.45767714
5MP0002009_preneoplasia3.18739410
6MP0002166_altered_tumor_susceptibility3.04326526
7MP0002877_abnormal_melanocyte_morpholog2.89190252
8MP0003724_increased_susceptibility_to2.76596877
9MP0003787_abnormal_imprinting2.70496630
10MP0004859_abnormal_synaptic_plasticity2.62467094
11MP0003183_abnormal_peptide_metabolism2.61853657
12MP0008961_abnormal_basal_metabolism2.46199994
13MP0003828_pulmonary_edema2.45654364
14MP0005551_abnormal_eye_electrophysiolog2.27301906
15MP0003045_fibrosis2.25411430
16MP0004510_myositis2.23948978
17MP0005076_abnormal_cell_differentiation2.22968375
18MP0008877_abnormal_DNA_methylation2.22051564
19MP0005248_abnormal_Harderian_gland2.20905976
20MP0002396_abnormal_hematopoietic_system2.20072836
21MP0003763_abnormal_thymus_physiology2.12934011
22MP0005464_abnormal_platelet_physiology2.11145583
23MP0003705_abnormal_hypodermis_morpholog2.03097813
24MP0002006_tumorigenesis2.00797262
25MP0010234_abnormal_vibrissa_follicle1.99840748
26MP0003656_abnormal_erythrocyte_physiolo1.96892007
27MP0004130_abnormal_muscle_cell1.88770590
28MP0008995_early_reproductive_senescence1.87637834
29MP0004808_abnormal_hematopoietic_stem1.80638777
30MP0003172_abnormal_lysosome_physiology1.80225932
31MP0003436_decreased_susceptibility_to1.66363000
32MP0005423_abnormal_somatic_nervous1.65939790
33MP0003252_abnormal_bile_duct1.64957958
34MP0008260_abnormal_autophagy1.63813028
35MP0002138_abnormal_hepatobiliary_system1.55853335
36MP0001915_intracranial_hemorrhage1.55047368
37MP0005187_abnormal_penis_morphology1.54298157
38MP0005409_darkened_coat_color1.53245464
39MP0001873_stomach_inflammation1.53123095
40MP0005451_abnormal_body_composition1.51883104
41MP0003690_abnormal_glial_cell1.48344062
42MP0003868_abnormal_feces_composition1.47458184
43MP0009278_abnormal_bone_marrow1.45655848
44MP0004264_abnormal_extraembryonic_tissu1.45590698
45MP0002405_respiratory_system_inflammati1.44582550
46MP0002419_abnormal_innate_immunity1.38048571
47MP0003635_abnormal_synaptic_transmissio1.36221803
48MP0008569_lethality_at_weaning1.33799580
49MP0002928_abnormal_bile_duct1.32317077
50MP0005025_abnormal_response_to1.31650918
51MP0004885_abnormal_endolymph1.31205913
52MP0001800_abnormal_humoral_immune1.30258511
53MP0000703_abnormal_thymus_morphology1.29728099
54MP0002095_abnormal_skin_pigmentation1.24503814
55MP0005671_abnormal_response_to1.23559091
56MP0010678_abnormal_skin_adnexa1.22612120
57MP0010155_abnormal_intestine_physiology1.19820970
58MP0004381_abnormal_hair_follicle1.19168188
59MP0009780_abnormal_chondrocyte_physiolo1.18945531
60MP0005310_abnormal_salivary_gland1.18450320
61MP0003866_abnormal_defecation1.17353354
62MP0000689_abnormal_spleen_morphology1.16901197
63MP0004134_abnormal_chest_morphology1.16213094
64MP0002722_abnormal_immune_system1.14713265
65MP0002398_abnormal_bone_marrow1.14251072
66MP0005253_abnormal_eye_physiology1.12739150
67MP0005174_abnormal_tail_pigmentation1.08510864
68MP0001545_abnormal_hematopoietic_system1.07972396
69MP0005397_hematopoietic_system_phenotyp1.07972396
70MP0000685_abnormal_immune_system1.06828672
71MP0004883_abnormal_blood_vessel1.05890886
72MP0001502_abnormal_circadian_rhythm1.05447819
73MP0005085_abnormal_gallbladder_physiolo1.04801197
74MP0005000_abnormal_immune_tolerance1.04666282
75MP0005365_abnormal_bile_salt1.04489168
76MP0006072_abnormal_retinal_apoptosis1.02335365
77MP0005387_immune_system_phenotype1.01146541
78MP0001790_abnormal_immune_system1.01146541
79MP0001270_distended_abdomen1.01116331
80MP0004484_altered_response_of0.99621419
81MP0002063_abnormal_learning/memory/cond0.99368265
82MP0005164_abnormal_response_to0.95856728
83MP0009115_abnormal_fat_cell0.94026187
84MP0000383_abnormal_hair_follicle0.92428757
85MP0000470_abnormal_stomach_morphology0.92144401
86MP0000015_abnormal_ear_pigmentation0.91743913
87MP0003011_delayed_dark_adaptation0.90362305
88MP0000427_abnormal_hair_cycle0.90272133
89MP0003191_abnormal_cellular_cholesterol0.90234228
90MP0000465_gastrointestinal_hemorrhage0.90189457
91MP0001486_abnormal_startle_reflex0.89831922
92MP0004185_abnormal_adipocyte_glucose0.88634328
93MP0003943_abnormal_hepatobiliary_system0.88391818
94MP0003632_abnormal_nervous_system0.87900743
95MP0002822_catalepsy0.87382456
96MP0009333_abnormal_splenocyte_physiolog0.87355455
97MP0002090_abnormal_vision0.86823179
98MP0010368_abnormal_lymphatic_system0.86150835
99MP0001188_hyperpigmentation0.85765805
100MP0003091_abnormal_cell_migration0.85407869
101MP0004036_abnormal_muscle_relaxation0.84466973
102MP0010352_gastrointestinal_tract_polyps0.84118924
103MP0001346_abnormal_lacrimal_gland0.83261848
104MP0002133_abnormal_respiratory_system0.82983555
105MP0005388_respiratory_system_phenotype0.82983555
106MP0002429_abnormal_blood_cell0.82260363
107MP0009703_decreased_birth_body0.82067625
108MP0009672_abnormal_birth_weight0.82010629
109MP0003890_abnormal_embryonic-extraembry0.81772719
110MP0003453_abnormal_keratinocyte_physiol0.81590609
111MP0000733_abnormal_muscle_development0.81366516
112MP0000716_abnormal_immune_system0.80469842
113MP0005075_abnormal_melanosome_morpholog0.79026551
114MP0000371_diluted_coat_color0.78472761
115MP0001845_abnormal_inflammatory_respons0.77658768
116MP0000003_abnormal_adipose_tissue0.77655622
117MP0003221_abnormal_cardiomyocyte_apopto0.77048738
118MP0002420_abnormal_adaptive_immunity0.75684806
119MP0001324_abnormal_eye_pigmentation0.75548161
120MP0004147_increased_porphyrin_level0.75529396
121MP0002723_abnormal_immune_serum0.75304932
122MP0009745_abnormal_behavioral_response0.74887604
123MP0001819_abnormal_immune_cell0.74553802
124MP0002572_abnormal_emotion/affect_behav0.74507662
125* MP0002086_abnormal_extraembryonic_tissu0.73281619
126MP0002168_other_aberrant_phenotype0.72993735
127MP0001835_abnormal_antigen_presentation0.72982032
128MP0005670_abnormal_white_adipose0.72834482
129MP0002139_abnormal_hepatobiliary_system0.72314985
130MP0002254_reproductive_system_inflammat0.72277775
131MP0005375_adipose_tissue_phenotype0.71940538
132MP0001661_extended_life_span0.71937535
133MP0009785_altered_susceptibility_to0.71533106
134MP0003633_abnormal_nervous_system0.71276754
135MP0003935_abnormal_craniofacial_develop0.70507527
136MP0001663_abnormal_digestive_system0.70147101
137MP0002452_abnormal_antigen_presenting0.69652172
138MP0006082_CNS_inflammation0.69535083
139MP0006138_congestive_heart_failure0.69346282
140MP0003115_abnormal_respiratory_system0.69285226
141MP0002925_abnormal_cardiovascular_devel0.69228767
142MP0004947_skin_inflammation0.69071681
143MP0002909_abnormal_adrenal_gland0.68203907
144MP0010630_abnormal_cardiac_muscle0.68025234
145MP0005666_abnormal_adipose_tissue0.67392504
146MP0003121_genomic_imprinting0.66798422
147MP0005646_abnormal_pituitary_gland0.66526854
148MP0001851_eye_inflammation0.65865419
149MP0001784_abnormal_fluid_regulation0.65313065
150MP0004811_abnormal_neuron_physiology0.64134661
151MP0000858_altered_metastatic_potential0.63920202
152MP0005621_abnormal_cell_physiology0.63866044
153MP0005195_abnormal_posterior_eye0.63786836

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.09444721
2Menstrual irregularities (HP:0000858)3.81639345
3Spontaneous hematomas (HP:0007420)3.66488042
4Hyperinsulinemic hypoglycemia (HP:0000825)3.41401729
5Eczematoid dermatitis (HP:0000976)3.33021735
6Gonadotropin excess (HP:0000837)3.31498907
7Resting tremor (HP:0002322)3.28082241
8Macroorchidism (HP:0000053)3.27741362
9Curly hair (HP:0002212)3.20125243
10Congenital stationary night blindness (HP:0007642)3.07690338
11Thickened helices (HP:0000391)2.82056298
12Narrow palate (HP:0000189)2.80310765
13Dysmetric saccades (HP:0000641)2.75042314
14Action tremor (HP:0002345)2.73943441
15Chest pain (HP:0100749)2.72200137
16Gingival bleeding (HP:0000225)2.71981108
17Volvulus (HP:0002580)2.69266601
18Trigonocephaly (HP:0000243)2.63875303
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61692739
20Submucous cleft hard palate (HP:0000176)2.60549363
21Neonatal hypoglycemia (HP:0001998)2.60157569
22Long eyelashes (HP:0000527)2.60073631
23Hyperacusis (HP:0010780)2.58204195
24Genetic anticipation (HP:0003743)2.53605758
25Central scotoma (HP:0000603)2.52917897
26Leiomyosarcoma (HP:0100243)2.52680290
27Uterine leiomyosarcoma (HP:0002891)2.52680290
28Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.46647526
29Obstructive sleep apnea (HP:0002870)2.44979831
30Malignant gastrointestinal tract tumors (HP:0006749)2.42468242
31Gastrointestinal carcinoma (HP:0002672)2.42468242
32Bony spicule pigmentary retinopathy (HP:0007737)2.42421634
33Renovascular hypertension (HP:0100817)2.42079303
34Neoplasm of the tracheobronchial system (HP:0100552)2.35117531
35Papillary thyroid carcinoma (HP:0002895)2.33973920
36Disinhibition (HP:0000734)2.33127380
37Short 4th metacarpal (HP:0010044)2.31949399
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31949399
39Chorioretinal atrophy (HP:0000533)2.30501269
40Optic neuritis (HP:0100653)2.30219469
41Retrobulbar optic neuritis (HP:0100654)2.30219469
42Cystic hygroma (HP:0000476)2.29837212
43Pigmentary retinal degeneration (HP:0001146)2.29091771
44Orchitis (HP:0100796)2.27628575
45Recurrent bacterial skin infections (HP:0005406)2.27281447
46Flat acetabular roof (HP:0003180)2.26961744
47Absent frontal sinuses (HP:0002688)2.25601734
48Abnormality of chromosome segregation (HP:0002916)2.25176372
49Neoplasm of the adrenal cortex (HP:0100641)2.24383653
50Elfin facies (HP:0004428)2.24355986
51Wide nose (HP:0000445)2.23721841
52Recurrent gram-negative bacterial infections (HP:0005420)2.22056581
53Truncal obesity (HP:0001956)2.19448433
54Subacute progressive viral hepatitis (HP:0006572)2.17019168
55Prolonged bleeding time (HP:0003010)2.16425920
56Obsessive-compulsive behavior (HP:0000722)2.13213145
57Myositis (HP:0100614)2.09922110
58Thrombophlebitis (HP:0004418)2.09631785
59Gingivitis (HP:0000230)2.09484780
60Abnormal platelet volume (HP:0011876)2.08872740
61Recurrent abscess formation (HP:0002722)2.07398253
62Epistaxis (HP:0000421)2.07367704
63Lower limb amyotrophy (HP:0007210)2.07090317
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06483708
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.06019980
66Stomatitis (HP:0010280)2.04762941
67Midline defect of the nose (HP:0004122)2.03898277
68Abnormal platelet function (HP:0011869)2.03795981
69Impaired platelet aggregation (HP:0003540)2.03795981
70Acute myeloid leukemia (HP:0004808)2.02756440
71Conjunctival telangiectasia (HP:0000524)2.01247811
72Heterotopia (HP:0002282)2.00912747
73Thyroid carcinoma (HP:0002890)1.98996010
74Abnormality of the nasal septum (HP:0000419)1.97277829
75Abnormality of the axillary hair (HP:0100134)1.96847460
76Abnormality of secondary sexual hair (HP:0009888)1.96847460
77Abnormal foot bone ossification (HP:0010675)1.95973973
78Transitional cell carcinoma of the bladder (HP:0006740)1.94382560
79Inappropriate behavior (HP:0000719)1.93880006
80Petechiae (HP:0000967)1.93692338
81Dyschromatopsia (HP:0007641)1.93144865
82Increased mean platelet volume (HP:0011877)1.93056282
83Deep philtrum (HP:0002002)1.92797872
84Increased CSF protein (HP:0002922)1.92368441
85Mask-like facies (HP:0000298)1.91304285
86Amaurosis fugax (HP:0100576)1.90456497
87Impaired vibratory sensation (HP:0002495)1.89716653
88Fatigue (HP:0012378)1.89609473
89Vitreoretinal degeneration (HP:0000655)1.88825355
90Thick eyebrow (HP:0000574)1.88336496
91Keratoconjunctivitis sicca (HP:0001097)1.86779780
92Cutis marmorata (HP:0000965)1.86268048
93Urinary bladder sphincter dysfunction (HP:0002839)1.85653393
94Recurrent fungal infections (HP:0002841)1.85165091
95Febrile seizures (HP:0002373)1.84978626
96Alveolar cell carcinoma (HP:0006519)1.84351831
97Scotoma (HP:0000575)1.83898758
98Pulmonary embolism (HP:0002204)1.83451857
99Partial agenesis of the corpus callosum (HP:0001338)1.83449925
100Coarse hair (HP:0002208)1.83023347
101Agammaglobulinemia (HP:0004432)1.82320077
102Bladder carcinoma (HP:0002862)1.82088615
103Bladder neoplasm (HP:0009725)1.82088615
104Distal lower limb amyotrophy (HP:0008944)1.81875310
105Lip pit (HP:0100267)1.80984233
106Pointed chin (HP:0000307)1.80414973
107Fair hair (HP:0002286)1.79902224
108Progressive cerebellar ataxia (HP:0002073)1.79862680
109Thickened calvaria (HP:0002684)1.77656434
110Polycythemia (HP:0001901)1.76520872
111Deep palmar crease (HP:0006191)1.75466586
112Depressed nasal tip (HP:0000437)1.74686466
113Hypochromic microcytic anemia (HP:0004840)1.74031296
114Pendular nystagmus (HP:0012043)1.73194937
115Osteomyelitis (HP:0002754)1.73062920
116Cerebral aneurysm (HP:0004944)1.72383637
117Impaired smooth pursuit (HP:0007772)1.72151207
118Neoplasm of the heart (HP:0100544)1.72003523
119Panhypogammaglobulinemia (HP:0003139)1.71821634
120Rectal prolapse (HP:0002035)1.71286252
121Viral hepatitis (HP:0006562)1.71194403
122Abnormality of the 4th metacarpal (HP:0010012)1.69808066
123Absent eyebrow (HP:0002223)1.69543011
124Scanning speech (HP:0002168)1.67436374
125Tapered finger (HP:0001182)1.66692638
126Gastrointestinal infarctions (HP:0005244)1.66344352
127Urethral obstruction (HP:0000796)1.65979370
128Hemiplegia (HP:0002301)1.65927324
129Syringomyelia (HP:0003396)1.65812508
130Spinal cord lesions (HP:0100561)1.65812508
131Overriding aorta (HP:0002623)1.65335446
132Micronodular cirrhosis (HP:0001413)1.64161593
133Tented upper lip vermilion (HP:0010804)1.64144625
134Relative macrocephaly (HP:0004482)1.63846595
135Stomach cancer (HP:0012126)1.63772915
136Renal cell carcinoma (HP:0005584)1.63653345
137Myocardial infarction (HP:0001658)1.63598809
138Arterial thrombosis (HP:0004420)1.63457216
139Hepatoblastoma (HP:0002884)1.62226255
140Abnormal rod and cone electroretinograms (HP:0008323)1.62212668
141Supernumerary ribs (HP:0005815)1.62062371
142Acanthocytosis (HP:0001927)1.61853704
143Germ cell neoplasia (HP:0100728)1.59551379
144Vertebral arch anomaly (HP:0008438)1.59332123
145Difficulty running (HP:0009046)1.59103321
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.58934157
147T lymphocytopenia (HP:0005403)1.58742528
148Recurrent viral infections (HP:0004429)1.58227417
149Hemoptysis (HP:0002105)1.58193987
150Abnormality of T cell number (HP:0011839)1.57947564
151Facial diplegia (HP:0001349)1.57055579
152Aqueductal stenosis (HP:0002410)1.56693910
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56598520
154Macular degeneration (HP:0000608)1.56345861
155Sandal gap (HP:0001852)1.55734739
156Synophrys (HP:0000664)1.55367212
157Abnormality of the common coagulation pathway (HP:0010990)1.54885617
158Gaze-evoked nystagmus (HP:0000640)1.54869963
159Widely spaced teeth (HP:0000687)1.54615812
160Open mouth (HP:0000194)1.53985852
161Papilledema (HP:0001085)1.53981545
162Oligodontia (HP:0000677)1.53327041
163Asymmetry of the thorax (HP:0001555)1.53140277
164Flat cornea (HP:0007720)1.51843181
165Abnormality of the lower motor neuron (HP:0002366)1.51196138
166Abnormality of macular pigmentation (HP:0008002)1.51078777
167Type II diabetes mellitus (HP:0005978)1.51077310
168Retinal atrophy (HP:0001105)1.50407496
169Hematochezia (HP:0002573)1.49892052
170Mitral valve prolapse (HP:0001634)1.49668913
171Absent speech (HP:0001344)1.49649693
172Drooling (HP:0002307)1.48876901
173Excessive salivation (HP:0003781)1.48876901
174Abnormality of ocular smooth pursuit (HP:0000617)1.48853015
175Insomnia (HP:0100785)1.48397467
176Abnormality of the parietal bone (HP:0002696)1.48386125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.94934125
2TNIK4.75638677
3BRD43.74386438
4PNCK3.46668806
5CDK122.83580650
6CAMK1G2.46474198
7MAP3K102.30246408
8RIPK42.29764442
9LATS12.09340834
10PIK3CG2.09164627
11TAOK31.96487831
12EEF2K1.90646703
13FGFR31.90327478
14PRKD31.90043854
15CAMK1D1.84323167
16SGK31.73528424
17FGFR21.66260381
18SGK21.63258580
19MAP3K71.60252738
20TXK1.58458003
21MAP3K41.55426110
22FES1.48372304
23TAOK11.46047372
24SIK21.45326758
25WNK11.45029285
26JAK11.44866893
27MAP4K11.41439264
28TRIB31.34558882
29DMPK1.32128744
30RIPK11.31489813
31BRAF1.28543029
32CAMKK11.28389300
33PRKCH1.27438061
34FGFR41.25990892
35JAK31.24342391
36GRK11.21792280
37STK111.17244604
38EPHA31.14775763
39YES11.13778907
40TYRO31.12086227
41IRAK41.10669779
42INSRR1.09838313
43ITK1.09521702
44PRKD21.08899286
45MARK21.08246641
46BLK1.03258216
47NTRK21.00553881
48FRK1.00050108
49RET0.99770268
50PRPF4B0.99452881
51SGK2230.99241943
52SGK4940.99241943
53NTRK30.98367311
54PTK60.95834660
55TNK20.95526095
56ICK0.94684314
57TAF10.94236720
58MAP3K140.94140834
59MAP3K130.90392620
60FGR0.89758108
61HIPK20.89696249
62PRKAA20.89639213
63CDK60.88733091
64PDGFRB0.88293770
65CHUK0.87197854
66MAP2K30.86870076
67SMG10.86198122
68EPHB10.85584070
69CAMK40.84159122
70NUAK10.83997478
71ALK0.83554338
72CSNK1A1L0.83271143
73DAPK20.83115480
74PKN20.82331771
75MTOR0.81815430
76SGK10.80730543
77STK380.79900143
78HCK0.79618058
79GRK60.75969571
80TTK0.75659523
81* CDK90.75627593
82PDGFRA0.73645824
83SIK10.73605552
84PAK60.70757135
85CAMK10.70127244
86MAP2K40.69327179
87NEK90.69068275
88IRAK10.67189449
89JAK20.66675901
90DYRK1A0.66522495
91IKBKE0.66223345
92PDK10.65516715
93CDK40.64873244
94KSR20.62508520
95TYK20.61429091
96MAP3K60.61087666
97CSK0.60479660
98MAP3K10.60278123
99SYK0.59491491
100CDC42BPA0.59475100
101RPS6KB10.59371369
102PRKAA10.58350445
103MINK10.58274675
104ACVR1B0.57932829
105FER0.56569917
106MELK0.55610219
107ZAP700.54296082
108CAMKK20.52680082
109MAP3K20.52613996
110MAP3K90.52286817
111KSR10.50814511
112KIT0.49334730
113LYN0.48417850
114TEC0.48402271
115BTK0.47247837
116STK30.46948949
117LCK0.46891241
118ERBB20.46724673
119CSNK1D0.46610566
120RPS6KA30.46554949
121RPS6KA20.46538019
122CLK10.46304115
123MAPK100.46200690
124PRKCQ0.46032538
125NLK0.46032486
126MAPK80.45909106
127FGFR10.45837104
128EPHA40.45517614
129PDPK10.45081884
130GSK3B0.43641667
131IRAK20.42666547
132NEK60.40633340
133MAP2K20.40506694
134DYRK30.39683253
135CSF1R0.39251142
136PRKCE0.37683845
137BRSK20.37635812
138MAPK70.34575272
139PIK3CA0.31121613

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.29310268
2Phototransduction_Homo sapiens_hsa047441.97478408
3Lysine degradation_Homo sapiens_hsa003101.91831774
4Nitrogen metabolism_Homo sapiens_hsa009101.89060250
5Dorso-ventral axis formation_Homo sapiens_hsa043201.52151760
6T cell receptor signaling pathway_Homo sapiens_hsa046601.43675682
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39641336
8Type II diabetes mellitus_Homo sapiens_hsa049301.39543167
9Olfactory transduction_Homo sapiens_hsa047401.36420945
10Primary immunodeficiency_Homo sapiens_hsa053401.35527221
11B cell receptor signaling pathway_Homo sapiens_hsa046621.30725360
12* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25406181
13Circadian entrainment_Homo sapiens_hsa047131.25154549
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24242463
15Long-term potentiation_Homo sapiens_hsa047201.23487881
16Renin secretion_Homo sapiens_hsa049241.20692640
17Non-small cell lung cancer_Homo sapiens_hsa052231.19984660
18Endometrial cancer_Homo sapiens_hsa052131.19367717
19Glioma_Homo sapiens_hsa052141.18905255
20Chronic myeloid leukemia_Homo sapiens_hsa052201.18191853
21Caffeine metabolism_Homo sapiens_hsa002321.17800965
22Staphylococcus aureus infection_Homo sapiens_hsa051501.15056705
23Hepatitis C_Homo sapiens_hsa051601.13713624
24mTOR signaling pathway_Homo sapiens_hsa041501.11431334
25Glutamatergic synapse_Homo sapiens_hsa047241.11224301
26cAMP signaling pathway_Homo sapiens_hsa040241.09119448
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.06463102
28Morphine addiction_Homo sapiens_hsa050321.04549020
29Tuberculosis_Homo sapiens_hsa051521.03329438
30Insulin secretion_Homo sapiens_hsa049111.03236451
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02842252
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02612612
33Insulin resistance_Homo sapiens_hsa049311.02514208
34Oxytocin signaling pathway_Homo sapiens_hsa049211.02474437
35Osteoclast differentiation_Homo sapiens_hsa043801.02369246
36Cholinergic synapse_Homo sapiens_hsa047251.02305591
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.01272160
38Salivary secretion_Homo sapiens_hsa049701.01099324
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01081075
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99244794
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98087998
42Prolactin signaling pathway_Homo sapiens_hsa049170.97671493
43ErbB signaling pathway_Homo sapiens_hsa040120.97318878
44Pancreatic cancer_Homo sapiens_hsa052120.96948888
45Circadian rhythm_Homo sapiens_hsa047100.96325213
46Influenza A_Homo sapiens_hsa051640.95608854
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95160335
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93691776
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92867665
50Fatty acid biosynthesis_Homo sapiens_hsa000610.92509560
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91661000
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90669595
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90126469
54Chemokine signaling pathway_Homo sapiens_hsa040620.89907813
55GnRH signaling pathway_Homo sapiens_hsa049120.88802203
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.88719851
57Long-term depression_Homo sapiens_hsa047300.88632057
58GABAergic synapse_Homo sapiens_hsa047270.88366474
59Gastric acid secretion_Homo sapiens_hsa049710.87508944
60Dopaminergic synapse_Homo sapiens_hsa047280.86023976
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85440675
62Acute myeloid leukemia_Homo sapiens_hsa052210.85311637
63Amphetamine addiction_Homo sapiens_hsa050310.84664856
64MAPK signaling pathway_Homo sapiens_hsa040100.84387125
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84060702
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83987592
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.83948530
68Toxoplasmosis_Homo sapiens_hsa051450.83361972
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.82639908
70Choline metabolism in cancer_Homo sapiens_hsa052310.81678101
71Platelet activation_Homo sapiens_hsa046110.81393645
72Estrogen signaling pathway_Homo sapiens_hsa049150.81318222
73Nicotine addiction_Homo sapiens_hsa050330.79886009
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78804517
75Viral myocarditis_Homo sapiens_hsa054160.78719549
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.77250410
77FoxO signaling pathway_Homo sapiens_hsa040680.76471423
78Cocaine addiction_Homo sapiens_hsa050300.76245813
79ABC transporters_Homo sapiens_hsa020100.76085913
80Inositol phosphate metabolism_Homo sapiens_hsa005620.75837278
81Glucagon signaling pathway_Homo sapiens_hsa049220.75723345
82Colorectal cancer_Homo sapiens_hsa052100.75561488
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71864105
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71781251
85Notch signaling pathway_Homo sapiens_hsa043300.71486674
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70990227
87Measles_Homo sapiens_hsa051620.70384160
88Viral carcinogenesis_Homo sapiens_hsa052030.69350090
89Hepatitis B_Homo sapiens_hsa051610.68541187
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.68533315
91VEGF signaling pathway_Homo sapiens_hsa043700.67867117
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67387165
93MicroRNAs in cancer_Homo sapiens_hsa052060.67129428
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66776533
95Dilated cardiomyopathy_Homo sapiens_hsa054140.66512469
96Amoebiasis_Homo sapiens_hsa051460.65751063
97Bile secretion_Homo sapiens_hsa049760.65404806
98Insulin signaling pathway_Homo sapiens_hsa049100.65372847
99Small cell lung cancer_Homo sapiens_hsa052220.64765050
100Complement and coagulation cascades_Homo sapiens_hsa046100.63455320
101TNF signaling pathway_Homo sapiens_hsa046680.63443524
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63236855
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62844905
104Rap1 signaling pathway_Homo sapiens_hsa040150.62570742
105AMPK signaling pathway_Homo sapiens_hsa041520.62416138
106Ras signaling pathway_Homo sapiens_hsa040140.61718243
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60952370
108Renal cell carcinoma_Homo sapiens_hsa052110.60064216
109Prostate cancer_Homo sapiens_hsa052150.59993368
110Leishmaniasis_Homo sapiens_hsa051400.59376105
111Thyroid hormone synthesis_Homo sapiens_hsa049180.58425170
112Axon guidance_Homo sapiens_hsa043600.58172337
113Wnt signaling pathway_Homo sapiens_hsa043100.58116764
114Proteoglycans in cancer_Homo sapiens_hsa052050.58091936
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57396004
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.57214580
117Ovarian steroidogenesis_Homo sapiens_hsa049130.57001738
118Melanogenesis_Homo sapiens_hsa049160.55983788
119Adherens junction_Homo sapiens_hsa045200.55634545
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55378039
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.55042291
122Tight junction_Homo sapiens_hsa045300.51728837
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51572205
124Basal cell carcinoma_Homo sapiens_hsa052170.50907181
125HIF-1 signaling pathway_Homo sapiens_hsa040660.50370957
126Pathways in cancer_Homo sapiens_hsa052000.48439030
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47254371
128Focal adhesion_Homo sapiens_hsa045100.47075739
129Endocytosis_Homo sapiens_hsa041440.46841779

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