NCOA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)7.58906839
2ear development (GO:0043583)5.02911051
3striated muscle atrophy (GO:0014891)4.94420124
4positive regulation of Cdc42 GTPase activity (GO:0043089)4.80742822
5regulation of establishment of cell polarity (GO:2000114)4.77021466
6intestinal epithelial cell development (GO:0060576)4.59668759
7regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.46789724
8skeletal muscle adaptation (GO:0043501)4.41717677
9regulation of establishment or maintenance of cell polarity (GO:0032878)4.32866094
10muscle atrophy (GO:0014889)4.31381633
11embryonic camera-type eye morphogenesis (GO:0048596)3.92740894
12regulation of centriole replication (GO:0046599)3.87249832
13nuclear pore complex assembly (GO:0051292)3.71195224
14TOR signaling (GO:0031929)3.69559819
15nuclear pore organization (GO:0006999)3.68882552
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.66082088
17positive regulation of gamma-delta T cell activation (GO:0046645)3.65159021
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53652002
19negative regulation of organelle assembly (GO:1902116)3.48748511
20cellular response to interferon-alpha (GO:0035457)3.44289316
21pore complex assembly (GO:0046931)3.36524198
22immunoglobulin mediated immune response (GO:0016064)3.34961246
23embryonic eye morphogenesis (GO:0048048)3.34057413
24interferon-gamma secretion (GO:0072643)3.30278195
25NIK/NF-kappaB signaling (GO:0038061)3.25914193
26regulation of cell proliferation involved in kidney development (GO:1901722)3.25579935
27CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.22986554
28COPI coating of Golgi vesicle (GO:0048205)3.14884716
29Golgi transport vesicle coating (GO:0048200)3.14884716
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.14833163
31regulation of B cell receptor signaling pathway (GO:0050855)3.11930683
32ER overload response (GO:0006983)3.11757977
33regulation of interleukin-13 production (GO:0032656)3.11594226
34insulin-like growth factor receptor signaling pathway (GO:0048009)3.05597206
35B cell mediated immunity (GO:0019724)3.04322000
36cell differentiation involved in embryonic placenta development (GO:0060706)3.01550781
37antigen processing and presentation of endogenous antigen (GO:0019883)2.98605283
38positive regulation of translational initiation (GO:0045948)2.96239287
39positive regulation of B cell differentiation (GO:0045579)2.95508110
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94956407
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94956407
42positive regulation by organism of defense response of other organism involved in symbiotic interact2.94956407
43modulation by symbiont of host immune response (GO:0052553)2.94956407
44positive regulation by symbiont of host defense response (GO:0052509)2.94956407
45modulation by symbiont of host defense response (GO:0052031)2.94956407
46CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.94305843
47T-helper cell differentiation (GO:0042093)2.94305843
48regulation of interferon-beta biosynthetic process (GO:0045357)2.94218565
49trophectodermal cell differentiation (GO:0001829)2.92210590
50histone H3-K4 trimethylation (GO:0080182)2.91810911
51negative thymic T cell selection (GO:0045060)2.91436845
52regulation of interleukin-12 biosynthetic process (GO:0045075)2.91284148
53positive regulation of interferon-alpha production (GO:0032727)2.90132713
54regulation of fatty acid beta-oxidation (GO:0031998)2.90058746
55regulation of interferon-alpha production (GO:0032647)2.86464220
56positive regulation of antigen processing and presentation (GO:0002579)2.84427474
57mitotic metaphase plate congression (GO:0007080)2.84027114
58negative regulation of DNA repair (GO:0045738)2.83342532
59protein localization to kinetochore (GO:0034501)2.82556416
60negative T cell selection (GO:0043383)2.82060811
61regulation of water loss via skin (GO:0033561)2.81717688
62positive thymic T cell selection (GO:0045059)2.79627448
63regulation of gamma-delta T cell differentiation (GO:0045586)2.77840506
64mammary gland epithelial cell proliferation (GO:0033598)2.77696044
65COPII vesicle coating (GO:0048208)2.77422791
66regulation of gamma-delta T cell activation (GO:0046643)2.77187560
67positive regulation of interleukin-4 production (GO:0032753)2.75919327
68regulation of B cell differentiation (GO:0045577)2.75884891
69mitotic nuclear envelope disassembly (GO:0007077)2.75344618
70regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73328230
71uterus development (GO:0060065)2.73313752
72embryonic process involved in female pregnancy (GO:0060136)2.70143364
73B cell homeostasis (GO:0001782)2.68297192
74positive regulation of nitric-oxide synthase activity (GO:0051000)2.67143053
75oocyte development (GO:0048599)2.66067636
76cell-substrate adherens junction assembly (GO:0007045)2.65706928
77focal adhesion assembly (GO:0048041)2.65706928
78T cell lineage commitment (GO:0002360)2.65576624
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.65231322
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65231322
81production of molecular mediator involved in inflammatory response (GO:0002532)2.63760199
82regulation of spindle organization (GO:0090224)2.63644007
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.63227143
84regulation of mitotic spindle organization (GO:0060236)2.62954258
85positive regulation of interferon-beta production (GO:0032728)2.62106065
86post-embryonic morphogenesis (GO:0009886)2.60032880
87negative regulation of interleukin-12 production (GO:0032695)2.59986497
88maternal placenta development (GO:0001893)2.59531760
89* positive regulation of keratinocyte differentiation (GO:0045618)2.59011140
90protein localization to chromosome, centromeric region (GO:0071459)2.58862398
91natural killer cell mediated cytotoxicity (GO:0042267)2.57654294
92natural killer cell mediated immunity (GO:0002228)2.57654294
93B cell receptor signaling pathway (GO:0050853)2.56859540
94negative regulation of B cell proliferation (GO:0030889)2.56554496
95negative regulation of granulocyte differentiation (GO:0030853)2.56476534
96neutrophil activation involved in immune response (GO:0002283)2.55802193
97negative regulation of histone methylation (GO:0031061)2.54831968
98lymphoid progenitor cell differentiation (GO:0002320)2.54477411
99regulation of RNA export from nucleus (GO:0046831)2.51825733
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.51795422
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.51795422
102positive regulation of mitotic sister chromatid separation (GO:1901970)2.51795422
103metaphase plate congression (GO:0051310)2.51396126
104activation of Rac GTPase activity (GO:0032863)2.51088615
105peptidyl-lysine trimethylation (GO:0018023)2.50842515
106nuclear envelope disassembly (GO:0051081)2.50410638
107membrane disassembly (GO:0030397)2.50410638
108determination of adult lifespan (GO:0008340)2.49189265
109protein K6-linked ubiquitination (GO:0085020)2.49094129
110pinocytosis (GO:0006907)2.48781924
111meiotic chromosome segregation (GO:0045132)2.48715300
112DNA replication checkpoint (GO:0000076)2.48349527
113spliceosomal tri-snRNP complex assembly (GO:0000244)2.48031144
114positive regulation of chromosome segregation (GO:0051984)2.47415969
115thymic T cell selection (GO:0045061)2.47381407
116mitotic sister chromatid cohesion (GO:0007064)2.47180788
117desmosome organization (GO:0002934)2.47085284
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45995292
119leukocyte aggregation (GO:0070486)2.45138347
120regulation of integrin activation (GO:0033623)2.44481782
121T cell differentiation involved in immune response (GO:0002292)2.44218829
122alpha-beta T cell differentiation involved in immune response (GO:0002293)2.44218829
123alpha-beta T cell activation involved in immune response (GO:0002287)2.44218829
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43894149
125myeloid dendritic cell activation (GO:0001773)2.42403373
126peptidyl-lysine dimethylation (GO:0018027)2.42176379
127establishment of chromosome localization (GO:0051303)2.41869614
128positive regulation of hormone metabolic process (GO:0032352)2.41732999
129response to interferon-alpha (GO:0035455)2.40735581
130cardiac right ventricle morphogenesis (GO:0003215)2.40559969
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40545732
132peptidyl-lysine methylation (GO:0018022)2.40242945
133regulation of histone H3-K27 methylation (GO:0061085)2.40094117
134corticosteroid receptor signaling pathway (GO:0031958)2.39676185
135intracellular estrogen receptor signaling pathway (GO:0030520)2.38618583
136inner cell mass cell proliferation (GO:0001833)2.38263750
137regulation of posttranscriptional gene silencing (GO:0060147)2.38240236
138regulation of gene silencing by miRNA (GO:0060964)2.38240236
139regulation of gene silencing by RNA (GO:0060966)2.38240236
140norepinephrine metabolic process (GO:0042415)2.38115199
141tolerance induction (GO:0002507)2.37904813
142cell proliferation involved in metanephros development (GO:0072203)2.37889090
143regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37867143
144neutrophil activation (GO:0042119)2.37711195
145germinal center formation (GO:0002467)2.37485549
146activation of Rho GTPase activity (GO:0032862)2.37238251
147DNA replication initiation (GO:0006270)2.36226161
148positive regulation of protein import into nucleus, translocation (GO:0033160)2.35605735
149regulation of antigen processing and presentation (GO:0002577)2.35394270
150response to muramyl dipeptide (GO:0032495)2.35388787
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.35379924
152somatic diversification of immune receptors via somatic mutation (GO:0002566)2.35379924
153chondrocyte development (GO:0002063)2.34795184
154interferon-gamma production (GO:0032609)2.34569339
155T cell selection (GO:0045058)2.34069857
156histone lysine demethylation (GO:0070076)2.33779705
157response to peptidoglycan (GO:0032494)2.33732598
158activation of Ras GTPase activity (GO:0032856)2.33701831
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33627932
160maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.33356393
161histone H3-K4 methylation (GO:0051568)2.33039028
162negative regulation of cell size (GO:0045792)2.32893055
163regulation of centrosome duplication (GO:0010824)2.32692380
164regulation of protein polyubiquitination (GO:1902914)2.32641075
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32593356
166regulation of RIG-I signaling pathway (GO:0039535)2.31908125
167mitotic sister chromatid segregation (GO:0000070)2.29552274
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.29454226
169regulation of T cell tolerance induction (GO:0002664)2.28267624
170regulation of histone H3-K9 methylation (GO:0051570)2.28035151
171histone H3-K36 demethylation (GO:0070544)2.27722648
172negative regulation of DNA-dependent DNA replication (GO:2000104)2.26979395
173regulation of chromatin silencing (GO:0031935)2.26782736
174mitotic chromosome condensation (GO:0007076)2.26372057
175telomere maintenance via recombination (GO:0000722)2.25927013
176positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25579784
177regulation of response to interferon-gamma (GO:0060330)2.25503177
178histone H4-K12 acetylation (GO:0043983)2.25349307
179granulocyte activation (GO:0036230)2.24666994
180regulation of telomere maintenance via telomerase (GO:0032210)2.24551424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79684229
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.85093288
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.07436456
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.87521432
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.81214680
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.45739706
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.45407268
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.32479501
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.32302696
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.28870591
11ESR1_15608294_ChIP-ChIP_MCF-7_Human3.19531874
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02034488
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.93375492
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69280852
15* AHR_22903824_ChIP-Seq_MCF-7_Human2.62321344
16* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.62107159
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56258629
18* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.43386944
19* RUNX1_27514584_Chip-Seq_MCF-7_Human2.41073107
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40369228
21MYC_22102868_ChIP-Seq_BL_Human2.37146739
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29483062
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24145205
24PKCTHETA_26484144_Chip-Seq_BREAST_Human2.23153181
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.16408872
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14028728
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13958364
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07899895
29* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06785332
30* ARNT_22903824_ChIP-Seq_MCF-7_Human2.01001726
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.97874303
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92952804
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87274774
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86454308
35* ER_23166858_ChIP-Seq_MCF-7_Human1.85817803
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85473495
37GATA1_22025678_ChIP-Seq_K562_Human1.81775664
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77049009
39SPI1_23547873_ChIP-Seq_NB4_Human1.75739377
40VDR_21846776_ChIP-Seq_THP-1_Human1.69867117
41MYB_26560356_Chip-Seq_TH2_Human1.69413598
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69195535
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68700320
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68484168
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68374446
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68374446
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68374446
48* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67956016
49* MYB_26560356_Chip-Seq_TH1_Human1.67732344
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67270314
51* RACK7_27058665_Chip-Seq_MCF-7_Human1.65129516
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.64972305
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61154737
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.61069543
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60004139
56* MAF_26560356_Chip-Seq_TH1_Human1.58195123
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56554644
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54247492
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.53971797
60* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53875029
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.51469324
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49862245
63ZNF263_19887448_ChIP-Seq_K562_Human1.49113298
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48992176
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48863487
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.47085072
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47048234
68SCL_19346495_ChIP-Seq_HPC-7_Human1.44846058
69* E2F1_21310950_ChIP-Seq_MCF-7_Human1.44477237
70* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44196547
71RUNX_20019798_ChIP-Seq_JUKART_Human1.43995825
72* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40496335
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40407948
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35657146
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34320742
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33639147
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.33136223
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32685849
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32569313
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32463133
81GATA6_25053715_ChIP-Seq_YYC3_Human1.31468745
82* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30782363
83* CIITA_25753668_ChIP-Seq_RAJI_Human1.29670941
84VDR_23849224_ChIP-Seq_CD4+_Human1.29623202
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28461833
86* TCF7_22412390_ChIP-Seq_EML_Mouse1.26671699
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25765690
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25531022
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25515756
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25515756
91TFEB_21752829_ChIP-Seq_HELA_Human1.23234949
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22520998
93UTX_26944678_Chip-Seq_JUKART_Human1.22445129
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21834758
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21663378
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21135443
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20504916
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20026150
99* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19874960
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19241566
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17932484
102VDR_24763502_ChIP-Seq_THP-1_Human1.17418066
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14620708
104SPI1_23127762_ChIP-Seq_K562_Human1.13477722
105PU_27001747_Chip-Seq_BMDM_Mouse1.12674871
106CHD1_26751641_Chip-Seq_LNCaP_Human1.10859441
107* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10342267
108* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09713567
109KDM5A_27292631_Chip-Seq_BREAST_Human1.09503617
110* ELF5_23300383_ChIP-Seq_T47D_Human1.09042643
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.07885367
112FOXP3_21729870_ChIP-Seq_TREG_Human1.07612264
113* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07519381
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07352867
115AR_21909140_ChIP-Seq_LNCAP_Human1.07206050
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06719544
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05379567
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04346777
119* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04114795
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02928590
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02503023
122MAF_26560356_Chip-Seq_TH2_Human1.02163295
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01433452
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00175561
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99996806
126MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99128689
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.98914740
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98830864
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98268315
130KDM2B_26808549_Chip-Seq_DND41_Human0.97807216
131ELK1_19687146_ChIP-ChIP_HELA_Human0.97206649
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97178825
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97171863
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92562393
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92312907
136MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91315591
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90887638
138* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90283003
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88919533
140E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88112570
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87928144
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87794324
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87331366
144GATA3_27048872_Chip-Seq_THYMUS_Human0.86749128
145* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86386012
146* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85733931
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83278011
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83182504
149XRN2_22483619_ChIP-Seq_HELA_Human0.82653016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle3.49901117
2MP0004264_abnormal_extraembryonic_tissu3.48620005
3MP0001835_abnormal_antigen_presentation3.48233251
4MP0008057_abnormal_DNA_replication2.90847444
5MP0005451_abnormal_body_composition2.84855010
6MP0002396_abnormal_hematopoietic_system2.50227797
7MP0003111_abnormal_nucleus_morphology2.50202015
8MP0001800_abnormal_humoral_immune2.49512706
9MP0002796_impaired_skin_barrier2.48371541
10MP0003693_abnormal_embryo_hatching2.47590167
11MP0010094_abnormal_chromosome_stability2.45970571
12MP0000383_abnormal_hair_follicle2.45240405
13MP0005671_abnormal_response_to2.42885705
14MP0003705_abnormal_hypodermis_morpholog2.41354070
15MP0010234_abnormal_vibrissa_follicle2.39391051
16MP0002877_abnormal_melanocyte_morpholog2.35996205
17MP0001790_abnormal_immune_system2.35109826
18MP0005387_immune_system_phenotype2.35109826
19MP0003077_abnormal_cell_cycle2.31622678
20MP0010678_abnormal_skin_adnexa2.25942273
21MP0003763_abnormal_thymus_physiology2.25267325
22MP0000685_abnormal_immune_system2.25175706
23MP0003303_peritoneal_inflammation2.24583737
24MP0002452_abnormal_antigen_presenting2.22080207
25MP0003436_decreased_susceptibility_to2.12292636
26MP0005000_abnormal_immune_tolerance2.09570002
27MP0010307_abnormal_tumor_latency2.08300823
28MP0003191_abnormal_cellular_cholesterol2.08280500
29MP0005408_hypopigmentation2.03495158
30MP0009780_abnormal_chondrocyte_physiolo2.02736075
31MP0002723_abnormal_immune_serum2.02040217
32MP0002148_abnormal_hypersensitivity_rea1.97432660
33MP0002420_abnormal_adaptive_immunity1.96291090
34MP0001819_abnormal_immune_cell1.95733745
35MP0004233_abnormal_muscle_weight1.95602599
36MP0002398_abnormal_bone_marrow1.94557147
37MP0002166_altered_tumor_susceptibility1.89473862
38MP0009333_abnormal_splenocyte_physiolog1.88541054
39MP0008007_abnormal_cellular_replicative1.81558668
40MP0008058_abnormal_DNA_repair1.79415946
41MP0002419_abnormal_innate_immunity1.79238666
42MP0000689_abnormal_spleen_morphology1.76515648
43MP0000716_abnormal_immune_system1.73953812
44MP0000427_abnormal_hair_cycle1.73167766
45MP0003183_abnormal_peptide_metabolism1.72772711
46MP0005025_abnormal_response_to1.70754730
47MP0004510_myositis1.69504205
48MP0002006_tumorigenesis1.67924817
49MP0002405_respiratory_system_inflammati1.66783996
50MP0002722_abnormal_immune_system1.65101448
51MP0004957_abnormal_blastocyst_morpholog1.64487716
52MP0004808_abnormal_hematopoietic_stem1.62711656
53MP0005501_abnormal_skin_physiology1.62221326
54MP0006082_CNS_inflammation1.61843767
55MP0010352_gastrointestinal_tract_polyps1.60128815
56MP0002098_abnormal_vibrissa_morphology1.56938814
57MP0009278_abnormal_bone_marrow1.55261750
58MP0000569_abnormal_digit_pigmentation1.54341183
59MP0009785_altered_susceptibility_to1.52224068
60MP0005397_hematopoietic_system_phenotyp1.51446837
61MP0001545_abnormal_hematopoietic_system1.51446837
62MP0000490_abnormal_crypts_of1.50326481
63MP0001873_stomach_inflammation1.49958939
64MP0005310_abnormal_salivary_gland1.49157544
65MP0002429_abnormal_blood_cell1.48847768
66MP0000703_abnormal_thymus_morphology1.43948898
67MP0000377_abnormal_hair_follicle1.43534601
68MP0002138_abnormal_hepatobiliary_system1.35886143
69MP0010155_abnormal_intestine_physiology1.35149097
70MP0002009_preneoplasia1.35012908
71MP0001853_heart_inflammation1.34742657
72MP0005464_abnormal_platelet_physiology1.34390511
73MP0003448_altered_tumor_morphology1.33498563
74MP0005409_darkened_coat_color1.30709182
75* MP0000350_abnormal_cell_proliferation1.30322892
76MP0003828_pulmonary_edema1.25284533
77MP0004185_abnormal_adipocyte_glucose1.25246441
78MP0002277_abnormal_respiratory_mucosa1.24078045
79MP0004782_abnormal_surfactant_physiolog1.22903250
80MP0003786_premature_aging1.20154812
81* MP0000627_abnormal_mammary_gland1.20011766
82MP0001845_abnormal_inflammatory_respons1.19321705
83MP0000371_diluted_coat_color1.18901171
84* MP0005076_abnormal_cell_differentiation1.18534468
85MP0001727_abnormal_embryo_implantation1.17282020
86MP0004947_skin_inflammation1.15522287
87MP0001348_abnormal_lacrimal_gland1.13839718
88MP0003724_increased_susceptibility_to1.13817926
89MP0000462_abnormal_digestive_system1.13733567
90MP0005075_abnormal_melanosome_morpholog1.13565492
91MP0003566_abnormal_cell_adhesion1.12907043
92* MP0002019_abnormal_tumor_incidence1.12425364
93MP0001216_abnormal_epidermal_layer1.09840087
94MP0000015_abnormal_ear_pigmentation1.08562780
95MP0001730_embryonic_growth_arrest1.08515550
96MP0000858_altered_metastatic_potential1.06933076
97MP0005058_abnormal_lysosome_morphology1.06486522
98MP0003300_gastrointestinal_ulcer1.06464839
99MP0000465_gastrointestinal_hemorrhage1.05000891
100MP0005380_embryogenesis_phenotype1.04644521
101MP0001672_abnormal_embryogenesis/_devel1.04644521
102MP0001881_abnormal_mammary_gland1.03831979
103MP0009672_abnormal_birth_weight1.02379862
104MP0000470_abnormal_stomach_morphology0.98944021
105MP0000313_abnormal_cell_death0.98524044
106MP0005174_abnormal_tail_pigmentation0.96245442
107MP0003984_embryonic_growth_retardation0.95927305
108MP0002088_abnormal_embryonic_growth/wei0.95364265
109MP0008260_abnormal_autophagy0.94721797
110MP0001666_abnormal_nutrient_absorption0.93880748
111MP0002086_abnormal_extraembryonic_tissu0.93650802
112MP0008877_abnormal_DNA_methylation0.92782503
113MP0003941_abnormal_skin_development0.92676245
114MP0008995_early_reproductive_senescence0.92443346
115MP0005023_abnormal_wound_healing0.91851658
116MP0004883_abnormal_blood_vessel0.91639067
117MP0001533_abnormal_skeleton_physiology0.90480685
118MP0003221_abnormal_cardiomyocyte_apopto0.88408815
119MP0002075_abnormal_coat/hair_pigmentati0.88132184
120MP0003787_abnormal_imprinting0.88017067
121MP0001186_pigmentation_phenotype0.87492286
122MP0003718_maternal_effect0.87123152
123MP0003123_paternal_imprinting0.85543760
124MP0002254_reproductive_system_inflammat0.84537099
125MP0003172_abnormal_lysosome_physiology0.84320915
126MP0009840_abnormal_foam_cell0.83707883
127MP0001915_intracranial_hemorrhage0.83178981
128MP0002933_joint_inflammation0.81370216
129MP0008932_abnormal_embryonic_tissue0.80586361
130MP0009703_decreased_birth_body0.79024834
131* MP0001697_abnormal_embryo_size0.78309636
132MP0008469_abnormal_protein_level0.77076832
133MP0009931_abnormal_skin_appearance0.76328841
134* MP0005621_abnormal_cell_physiology0.74558289
135MP0000767_abnormal_smooth_muscle0.73949542
136MP0005367_renal/urinary_system_phenotyp0.73176734
137MP0000516_abnormal_urinary_system0.73176734
138MP0003567_abnormal_fetal_cardiomyocyte0.72205278
139MP0003091_abnormal_cell_migration0.71294665
140MP0003453_abnormal_keratinocyte_physiol0.71034379

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)5.87962766
2Asymmetry of the thorax (HP:0001555)5.72110604
3Absent frontal sinuses (HP:0002688)5.20943599
4Micronodular cirrhosis (HP:0001413)4.50888694
5Microglossia (HP:0000171)4.17209824
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.09015531
7Recurrent abscess formation (HP:0002722)4.03072119
8Abnormality of the fingertips (HP:0001211)3.92213312
9Deformed sella turcica (HP:0002681)3.88651720
10Papillary thyroid carcinoma (HP:0002895)3.86627643
11Septate vagina (HP:0001153)3.85456418
12Chromsome breakage (HP:0040012)3.68712945
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68083693
14Curly hair (HP:0002212)3.56939305
15Recurrent bacterial skin infections (HP:0005406)3.50185365
16Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.48759674
17Abnormality of the frontal sinuses (HP:0002687)3.46111685
18Eczematoid dermatitis (HP:0000976)3.36500482
19Macroorchidism (HP:0000053)3.17012945
20Thyroid carcinoma (HP:0002890)3.16826380
21Recurrent fungal infections (HP:0002841)3.14737478
22Breast carcinoma (HP:0003002)3.11915325
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.11269733
24Spinal cord lesions (HP:0100561)3.09521175
25Syringomyelia (HP:0003396)3.09521175
26Testicular neoplasm (HP:0010788)3.08339670
27Autoimmune thrombocytopenia (HP:0001973)3.07968062
28Agnosia (HP:0010524)3.03560035
29Recurrent viral infections (HP:0004429)3.03197097
30Germ cell neoplasia (HP:0100728)3.00326878
31Pustule (HP:0200039)2.96706281
32Myositis (HP:0100614)2.93304477
33Birth length less than 3rd percentile (HP:0003561)2.92709637
34Cutaneous melanoma (HP:0012056)2.89040520
35Deep philtrum (HP:0002002)2.89035422
36Esophageal varix (HP:0002040)2.85036794
37Abnormality of the sella turcica (HP:0002679)2.83469108
38Optic neuritis (HP:0100653)2.81153449
39Retrobulbar optic neuritis (HP:0100654)2.81153449
40Intestinal fistula (HP:0100819)2.80332344
41Prostate neoplasm (HP:0100787)2.79155957
42IgM deficiency (HP:0002850)2.75767521
43Nephroblastoma (Wilms tumor) (HP:0002667)2.72196801
44Ectopic kidney (HP:0000086)2.71379477
45Mediastinal lymphadenopathy (HP:0100721)2.68750858
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.68435397
47Abnormality of chromosome stability (HP:0003220)2.58719372
48Hyperacusis (HP:0010780)2.55360744
49Orchitis (HP:0100796)2.55283621
50Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.52945395
51Amaurosis fugax (HP:0100576)2.52607072
52Impulsivity (HP:0100710)2.52072184
53Embryonal renal neoplasm (HP:0011794)2.51669204
54Flat acetabular roof (HP:0003180)2.46813629
55Agammaglobulinemia (HP:0004432)2.44634606
56Clubbing of toes (HP:0100760)2.43650701
57Leiomyosarcoma (HP:0100243)2.42483009
58Uterine leiomyosarcoma (HP:0002891)2.42483009
59Meckel diverticulum (HP:0002245)2.41743220
60Chronic mucocutaneous candidiasis (HP:0002728)2.40548015
61Recurrent cutaneous fungal infections (HP:0011370)2.40548015
62Transitional cell carcinoma of the bladder (HP:0006740)2.38763803
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.37387798
64Myelodysplasia (HP:0002863)2.36812996
65Cellulitis (HP:0100658)2.35161989
66Gastrointestinal stroma tumor (HP:0100723)2.33434571
67Chronic otitis media (HP:0000389)2.32505466
68Panhypogammaglobulinemia (HP:0003139)2.31375256
69Abnormality of the ileum (HP:0001549)2.30639524
70Meningitis (HP:0001287)2.30602661
71Leukopenia (HP:0001882)2.30360711
72Bladder carcinoma (HP:0002862)2.29629597
73Bladder neoplasm (HP:0009725)2.29629597
74Stomatitis (HP:0010280)2.29590502
75Abnormality of T cell number (HP:0011839)2.27792265
76IgA deficiency (HP:0002720)2.27771716
77Eosinophilia (HP:0001880)2.27288353
78Termporal pattern (HP:0011008)2.26600724
79Insidious onset (HP:0003587)2.26600724
80Recurrent skin infections (HP:0001581)2.24805769
81Abnormality of the preputium (HP:0100587)2.22985936
82Leukocytosis (HP:0001974)2.21610972
83Acute myeloid leukemia (HP:0004808)2.20931218
84Abnormality of macrophages (HP:0004311)2.20359515
85Hypopigmentation of the fundus (HP:0007894)2.19351058
86Arterial thrombosis (HP:0004420)2.18765132
87Obstructive lung disease (HP:0006536)2.18748556
88Chronic obstructive pulmonary disease (HP:0006510)2.18748556
89Vasculitis (HP:0002633)2.18213350
90Lymphoma (HP:0002665)2.18209125
91Viral hepatitis (HP:0006562)2.17258823
92T lymphocytopenia (HP:0005403)2.16705221
93Heterotopia (HP:0002282)2.16467007
94Sparse lateral eyebrow (HP:0005338)2.15648518
95Neoplasm of the thyroid gland (HP:0100031)2.15641973
96Subacute progressive viral hepatitis (HP:0006572)2.15463328
97Menstrual irregularities (HP:0000858)2.14725551
98Hematochezia (HP:0002573)2.13280964
99Colitis (HP:0002583)2.13037170
100Periodontitis (HP:0000704)2.12646186
101Abdominal distention (HP:0003270)2.11501386
102Abnormality of T cells (HP:0002843)2.11441461
103Recurrent bronchitis (HP:0002837)2.10567060
104Coarse hair (HP:0002208)2.08622040
105Concave nail (HP:0001598)2.07713839
106Rectal fistula (HP:0100590)2.05297475
107Rectovaginal fistula (HP:0000143)2.05297475
108Medulloblastoma (HP:0002885)2.04956491
109Abnormality of the prostate (HP:0008775)2.04423256
110Granulocytopenia (HP:0001913)2.04036916
111Elevated erythrocyte sedimentation rate (HP:0003565)2.03814216
112Renal cell carcinoma (HP:0005584)2.03524924
113IgG deficiency (HP:0004315)2.02998583
114Gingivitis (HP:0000230)2.00666448
115Anal stenosis (HP:0002025)1.99769454
116Systemic lupus erythematosus (HP:0002725)1.99436744
117Urethral obstruction (HP:0000796)1.99063439
118Bone marrow hypocellularity (HP:0005528)1.98936125
119Abnormality of T cell physiology (HP:0011840)1.98919205
120Inflammation of the large intestine (HP:0002037)1.96718591
121Breast hypoplasia (HP:0003187)1.95735247
122Pulmonary infiltrates (HP:0002113)1.94863619
123Malignant gastrointestinal tract tumors (HP:0006749)1.94168130
124Gastrointestinal carcinoma (HP:0002672)1.94168130
125Carpal bone hypoplasia (HP:0001498)1.93423742
126Autoimmune hemolytic anemia (HP:0001890)1.93235395
127Prominent nose (HP:0000448)1.92249437
128Abnormality of eosinophils (HP:0001879)1.90331173
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.89781562
130Spontaneous hematomas (HP:0007420)1.89780486
131Verrucae (HP:0200043)1.88624572
132Papilloma (HP:0012740)1.88624572
133Basal cell carcinoma (HP:0002671)1.87896928
134Abnormality of glycolipid metabolism (HP:0010969)1.87763578
135Abnormality of liposaccharide metabolism (HP:0010968)1.87763578
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.87763578
137Ependymoma (HP:0002888)1.87432100
138Patellar aplasia (HP:0006443)1.87147039
139Thyroiditis (HP:0100646)1.86946097
140Lymphopenia (HP:0001888)1.86932331
141Chronic diarrhea (HP:0002028)1.86130895
142Abnormality of the gastric mucosa (HP:0004295)1.85993836
143Enlarged penis (HP:0000040)1.85471747
144Keratoconjunctivitis sicca (HP:0001097)1.85042185
145Depressed nasal tip (HP:0000437)1.85023262
146Absent radius (HP:0003974)1.83923550
147Abnormality of DNA repair (HP:0003254)1.83912019
148Encephalitis (HP:0002383)1.82131392
149Osteomyelitis (HP:0002754)1.81828784
150Broad face (HP:0000283)1.81594199
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80963466
152Fatigue (HP:0012378)1.80810231
153Hepatitis (HP:0012115)1.80791357
154Thin bony cortex (HP:0002753)1.79027272
155High pitched voice (HP:0001620)1.78885116
156Gastrointestinal inflammation (HP:0004386)1.78355653
157Emphysema (HP:0002097)1.77462412
158Lip pit (HP:0100267)1.77091543
159Recurrent gram-negative bacterial infections (HP:0005420)1.75672415
160Long eyelashes (HP:0000527)1.75485870
161Long toe (HP:0010511)1.71265919
162Hyporeflexia of lower limbs (HP:0002600)1.70633740
163Deep venous thrombosis (HP:0002625)1.69777484
164Cafe-au-lait spot (HP:0000957)1.66654094
165Distal lower limb muscle weakness (HP:0009053)1.65677540
166Slow saccadic eye movements (HP:0000514)1.65265472
167Cystic hygroma (HP:0000476)1.60702132
168Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59951388
169Abnormal foot bone ossification (HP:0010675)1.56343385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.88590104
2SCYL24.57868255
3PIK3CA3.67462066
4CDK123.57874923
5MAP4K13.48725229
6PKN23.33043453
7SIK13.25570089
8MAP3K142.88156963
9NEK62.71517742
10SMG12.59645668
11JAK32.46993955
12SIK32.42674126
13TYK22.41936254
14TXK2.40124032
15STK102.24827309
16MAPKAPK32.07807744
17IRAK32.01730468
18PIM11.94371426
19IRAK41.86307095
20KIT1.72322654
21NEK21.71431536
22* IKBKB1.70762953
23STK41.63151060
24ZAP701.59952505
25ZAK1.59493977
26BRD41.57475339
27IKBKE1.55596691
28MKNK21.54858326
29CSF1R1.53101880
30WEE11.52251179
31AKT31.50077544
32SRPK11.49088678
33CDC71.47352523
34TGFBR21.47282469
35JAK11.46827082
36BLK1.45011486
37MAP3K121.43215426
38MAP2K21.39382367
39* CHUK1.34951615
40TTK1.34706751
41TSSK61.33584649
42MKNK11.33406399
43CLK11.32859479
44ERN11.27692042
45BUB11.25556303
46STK31.25024326
47EPHA21.22815783
48CDK41.22404213
49RPS6KB11.20644373
50FGFR31.14841172
51LATS11.14026705
52BMPR21.13322225
53MARK31.12334418
54CSK1.10832023
55TEC1.10032120
56ATR1.09539830
57ICK1.07115394
58PLK41.06693441
59EIF2AK31.06206626
60TBK11.06080132
61BTK1.05792582
62LCK1.04075470
63MUSK1.02765984
64HCK1.02667540
65NLK0.98755106
66PLK10.98070896
67SYK0.97745347
68STK38L0.96457122
69RPS6KA40.96126440
70NEK90.96011160
71TAF10.94489720
72PDPK10.92729233
73PDK10.92695353
74CAMK1D0.90631676
75CDK70.90621734
76CHEK20.90320776
77MAP3K90.89523600
78STK240.89013719
79FGFR40.86926451
80RET0.86149432
81EEF2K0.85968806
82CDK60.85278586
83MAP2K10.84617728
84EIF2AK20.84265746
85MAP2K30.83328053
86ITK0.82404081
87YES10.79499446
88BRSK20.78545706
89MAP3K80.78433277
90MAP3K20.76484244
91CHEK10.75869181
92LRRK20.75171699
93PLK30.74479949
94PTK60.74270836
95AURKB0.73756753
96FLT30.72249759
97PRPF4B0.71354855
98MELK0.71154056
99MAPK110.70722644
100EPHB10.70138805
101TAOK30.70002180
102JAK20.69546312
103EIF2AK10.69531431
104TRIM280.69435844
105MAPKAPK20.69298449
106LYN0.68767762
107ALK0.68647089
108RIPK40.68629267
109PRKCI0.68451186
110MAP3K130.67346428
111ATM0.66569353
112FGFR20.66132871
113NUAK10.65230510
114TTN0.64707286
115KSR10.64108575
116ACVR1B0.63819916
117RPS6KA20.62380527
118VRK10.60884019
119TRPM70.60479842
120RPS6KB20.60333368
121SGK30.60006518
122RPS6KA50.58466828
123GRK60.58354694
124SGK20.58016135
125TLK10.57516740
126CDK90.57201607
127IRAK20.56149489
128PDGFRA0.54285658
129CDK20.54024924
130ILK0.51187599
131MAP3K30.50025804
132KSR20.49925468
133NME20.49721371
134PAK40.47102723
135PIM20.46921123
136MTOR0.44387411
137HIPK20.41941385
138* ABL10.41055651
139MAP3K100.40566373
140PASK0.37777598
141MST40.37048133
142TESK20.33638400
143RPS6KC10.30009638
144RPS6KL10.30009638
145MAP3K10.29263538
146PRKD10.28008982
147PBK0.25120860

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.36569544
2Primary immunodeficiency_Homo sapiens_hsa053402.34651004
3DNA replication_Homo sapiens_hsa030302.29514636
4Mismatch repair_Homo sapiens_hsa034302.28647337
5Endometrial cancer_Homo sapiens_hsa052132.27658161
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22521743
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.04482143
8Measles_Homo sapiens_hsa051621.95413097
9Base excision repair_Homo sapiens_hsa034101.86772891
10Leishmaniasis_Homo sapiens_hsa051401.85985164
11Renal cell carcinoma_Homo sapiens_hsa052111.85967053
12Homologous recombination_Homo sapiens_hsa034401.85250557
13Herpes simplex infection_Homo sapiens_hsa051681.83466410
14Antigen processing and presentation_Homo sapiens_hsa046121.76193167
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75954827
16B cell receptor signaling pathway_Homo sapiens_hsa046621.75337479
17Fanconi anemia pathway_Homo sapiens_hsa034601.73742347
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73358757
19Allograft rejection_Homo sapiens_hsa053301.73194426
20Cell cycle_Homo sapiens_hsa041101.65483432
21One carbon pool by folate_Homo sapiens_hsa006701.62453064
22RNA transport_Homo sapiens_hsa030131.62392607
23Osteoclast differentiation_Homo sapiens_hsa043801.60222130
24p53 signaling pathway_Homo sapiens_hsa041151.59167205
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59083853
26RNA polymerase_Homo sapiens_hsa030201.49404062
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46948312
28ErbB signaling pathway_Homo sapiens_hsa040121.46802586
29Spliceosome_Homo sapiens_hsa030401.46106479
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44753103
31* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.44631509
32Glioma_Homo sapiens_hsa052141.43873023
33Influenza A_Homo sapiens_hsa051641.43688831
34Hematopoietic cell lineage_Homo sapiens_hsa046401.43283343
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.42979418
36VEGF signaling pathway_Homo sapiens_hsa043701.40915717
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.40843724
38Staphylococcus aureus infection_Homo sapiens_hsa051501.39810002
39Other glycan degradation_Homo sapiens_hsa005111.36753081
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36133181
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34364920
42Choline metabolism in cancer_Homo sapiens_hsa052311.33604231
43Apoptosis_Homo sapiens_hsa042101.32292510
44Epstein-Barr virus infection_Homo sapiens_hsa051691.31853153
45Nucleotide excision repair_Homo sapiens_hsa034201.31179404
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.30793312
47Non-homologous end-joining_Homo sapiens_hsa034501.30128417
48Toxoplasmosis_Homo sapiens_hsa051451.29646426
49Insulin resistance_Homo sapiens_hsa049311.29207523
50Autoimmune thyroid disease_Homo sapiens_hsa053201.23441309
51T cell receptor signaling pathway_Homo sapiens_hsa046601.21280527
52Bladder cancer_Homo sapiens_hsa052191.19404292
53Basal transcription factors_Homo sapiens_hsa030221.16299216
54Graft-versus-host disease_Homo sapiens_hsa053321.15882378
55Asthma_Homo sapiens_hsa053101.15641599
56RNA degradation_Homo sapiens_hsa030181.14767043
57Insulin signaling pathway_Homo sapiens_hsa049101.14248049
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13259553
59Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11142862
60Legionellosis_Homo sapiens_hsa051341.10641073
61AMPK signaling pathway_Homo sapiens_hsa041521.10162847
62Viral carcinogenesis_Homo sapiens_hsa052031.08325691
63Viral myocarditis_Homo sapiens_hsa054161.08047607
64Hepatitis B_Homo sapiens_hsa051611.06897582
65Tuberculosis_Homo sapiens_hsa051521.05786944
66Small cell lung cancer_Homo sapiens_hsa052221.04402281
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03474380
68Acute myeloid leukemia_Homo sapiens_hsa052211.03461660
69Proteoglycans in cancer_Homo sapiens_hsa052051.02258816
70Estrogen signaling pathway_Homo sapiens_hsa049151.02083366
71Sphingolipid signaling pathway_Homo sapiens_hsa040711.01759812
72HTLV-I infection_Homo sapiens_hsa051661.01119532
73Notch signaling pathway_Homo sapiens_hsa043300.99466943
74MicroRNAs in cancer_Homo sapiens_hsa052060.99129509
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98583273
76Chemokine signaling pathway_Homo sapiens_hsa040620.97023962
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95603715
78mRNA surveillance pathway_Homo sapiens_hsa030150.95397553
79TNF signaling pathway_Homo sapiens_hsa046680.90521413
80Chronic myeloid leukemia_Homo sapiens_hsa052200.88710408
81Shigellosis_Homo sapiens_hsa051310.86868737
82Pentose phosphate pathway_Homo sapiens_hsa000300.83300097
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83001245
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82826952
85Pertussis_Homo sapiens_hsa051330.82624088
86Pyrimidine metabolism_Homo sapiens_hsa002400.80607831
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.80468038
88Melanoma_Homo sapiens_hsa052180.79384413
89Malaria_Homo sapiens_hsa051440.79081255
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.78488768
91Type I diabetes mellitus_Homo sapiens_hsa049400.76465480
92Lysosome_Homo sapiens_hsa041420.73918036
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73647457
94Pancreatic cancer_Homo sapiens_hsa052120.71758347
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71008724
96Adherens junction_Homo sapiens_hsa045200.70236130
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68304605
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68241591
99Hepatitis C_Homo sapiens_hsa051600.65088382
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64798951
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63498939
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.62988496
103Prostate cancer_Homo sapiens_hsa052150.62512301
104Dorso-ventral axis formation_Homo sapiens_hsa043200.61252018
105Lysine degradation_Homo sapiens_hsa003100.60518578
106Colorectal cancer_Homo sapiens_hsa052100.59532610
107Systemic lupus erythematosus_Homo sapiens_hsa053220.58790298
108FoxO signaling pathway_Homo sapiens_hsa040680.58447370
109Prolactin signaling pathway_Homo sapiens_hsa049170.58276194
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.58271067
111Endocytosis_Homo sapiens_hsa041440.58185454
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57275360
113Salmonella infection_Homo sapiens_hsa051320.56765098
114Type II diabetes mellitus_Homo sapiens_hsa049300.56247764
115Pathways in cancer_Homo sapiens_hsa052000.55438604
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54180125
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53637586
118Inositol phosphate metabolism_Homo sapiens_hsa005620.52017482
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51203010
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51135401
121Vitamin B6 metabolism_Homo sapiens_hsa007500.49694951
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48621577
123Platelet activation_Homo sapiens_hsa046110.48487941
124TGF-beta signaling pathway_Homo sapiens_hsa043500.48034808
125N-Glycan biosynthesis_Homo sapiens_hsa005100.46396601
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.45341179
127Thyroid cancer_Homo sapiens_hsa052160.44810076
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44487950
129HIF-1 signaling pathway_Homo sapiens_hsa040660.44477624
130Regulation of autophagy_Homo sapiens_hsa041400.43205437
131GnRH signaling pathway_Homo sapiens_hsa049120.42016559
132Rheumatoid arthritis_Homo sapiens_hsa053230.39842291
133Non-small cell lung cancer_Homo sapiens_hsa052230.38472089
134mTOR signaling pathway_Homo sapiens_hsa041500.38261527

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »