NCOA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.05291846
2protoporphyrinogen IX biosynthetic process (GO:0006782)4.71214086
3negative regulation of cell killing (GO:0031342)4.57882172
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.57882172
5positive regulation by symbiont of host defense response (GO:0052509)4.48655149
6modulation by symbiont of host defense response (GO:0052031)4.48655149
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48655149
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48655149
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.48655149
10modulation by symbiont of host immune response (GO:0052553)4.48655149
11cellular extravasation (GO:0045123)4.45399360
12detection of molecule of bacterial origin (GO:0032490)4.17392260
13valine metabolic process (GO:0006573)4.14993920
14microglial cell activation (GO:0001774)4.13264220
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09827854
16alpha-linolenic acid metabolic process (GO:0036109)4.09474531
17neutrophil activation (GO:0042119)4.02157957
18regulation of B cell receptor signaling pathway (GO:0050855)3.94770409
19leukocyte migration involved in inflammatory response (GO:0002523)3.90963312
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.88396600
21regulation of platelet aggregation (GO:0090330)3.87971566
22detection of other organism (GO:0098543)3.87807381
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81228933
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81228933
25granulocyte activation (GO:0036230)3.69404822
26response to peptidoglycan (GO:0032494)3.68258891
27cysteine metabolic process (GO:0006534)3.67258205
28detection of external biotic stimulus (GO:0098581)3.65490086
29macrophage activation involved in immune response (GO:0002281)3.65227444
30negative regulation of erythrocyte differentiation (GO:0045647)3.65004148
31sulfur amino acid catabolic process (GO:0000098)3.64475542
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59957230
33regulation of triglyceride catabolic process (GO:0010896)3.59272975
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.57953897
35killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.57953897
36positive regulation of mast cell activation (GO:0033005)3.57146413
37regulation of gamma-delta T cell activation (GO:0046643)3.57097781
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.53582885
39L-phenylalanine catabolic process (GO:0006559)3.53582885
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.51016864
41plasma lipoprotein particle assembly (GO:0034377)3.50256404
42regulation of mast cell degranulation (GO:0043304)3.49171531
43urea cycle (GO:0000050)3.48913383
44urea metabolic process (GO:0019627)3.48913383
45lysine metabolic process (GO:0006553)3.45630879
46lysine catabolic process (GO:0006554)3.45630879
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44171600
48macrophage activation (GO:0042116)3.41823220
49detection of bacterium (GO:0016045)3.41650707
50pentose-phosphate shunt (GO:0006098)3.41557683
51regulation of gamma-delta T cell differentiation (GO:0045586)3.39596201
52L-phenylalanine metabolic process (GO:0006558)3.36367893
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36367893
54positive regulation of B cell differentiation (GO:0045579)3.34742144
55neutrophil mediated immunity (GO:0002446)3.32878920
56response to host immune response (GO:0052572)3.32471385
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32471385
58NADPH regeneration (GO:0006740)3.32367873
59myeloid cell activation involved in immune response (GO:0002275)3.26019164
60negative regulation of interleukin-12 production (GO:0032695)3.24364403
61regulation of mast cell activation involved in immune response (GO:0033006)3.23851910
62regulation of platelet activation (GO:0010543)3.23777234
63reverse cholesterol transport (GO:0043691)3.22496390
64protein-lipid complex assembly (GO:0065005)3.22471664
65phospholipid efflux (GO:0033700)3.19412259
66high-density lipoprotein particle remodeling (GO:0034375)3.19004988
67antigen processing and presentation of endogenous antigen (GO:0019883)3.18815049
68aromatic amino acid family catabolic process (GO:0009074)3.18448745
69positive regulation of cellular amide metabolic process (GO:0034250)3.18228643
70nitrogen cycle metabolic process (GO:0071941)3.16795655
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16403646
72complement activation, alternative pathway (GO:0006957)3.15665395
73amino-acid betaine metabolic process (GO:0006577)3.14716192
74detection of biotic stimulus (GO:0009595)3.14682828
75plasma lipoprotein particle remodeling (GO:0034369)3.14251077
76protein-lipid complex remodeling (GO:0034368)3.14251077
77macromolecular complex remodeling (GO:0034367)3.14251077
78regulation of leukocyte degranulation (GO:0043300)3.10984048
79phospholipid homeostasis (GO:0055091)3.10608940
80megakaryocyte development (GO:0035855)3.10102630
81plasma lipoprotein particle organization (GO:0071827)3.09496196
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08495184
83heme biosynthetic process (GO:0006783)3.07224372
84hepatocyte apoptotic process (GO:0097284)3.06747193
85regulation of mast cell activation (GO:0033003)3.05629886
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05602465
87response to host (GO:0075136)3.05602465
88response to host defenses (GO:0052200)3.05602465
89B cell receptor signaling pathway (GO:0050853)3.03337387
90negative regulation of lymphocyte mediated immunity (GO:0002707)3.02696324
91positive regulation of granulocyte differentiation (GO:0030854)3.02561397
92glyoxylate metabolic process (GO:0046487)3.02292929
93porphyrin-containing compound biosynthetic process (GO:0006779)3.01718600
94respiratory burst (GO:0045730)2.99112796
952-oxoglutarate metabolic process (GO:0006103)2.98258261
96very-low-density lipoprotein particle assembly (GO:0034379)2.97793767
97low-density lipoprotein particle remodeling (GO:0034374)2.97491671
98protein-lipid complex subunit organization (GO:0071825)2.95992812
99leukocyte degranulation (GO:0043299)2.95276894
100cholesterol efflux (GO:0033344)2.94837253
101peptidyl-glutamic acid carboxylation (GO:0017187)2.91738800
102protein carboxylation (GO:0018214)2.91738800
103bile acid biosynthetic process (GO:0006699)2.91477733
104negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91421423
105regulation of interferon-beta biosynthetic process (GO:0045357)2.90698880
106tryptophan metabolic process (GO:0006568)2.90069286
107ethanol oxidation (GO:0006069)2.89366338
108plasma lipoprotein particle clearance (GO:0034381)2.89121358
109killing of cells of other organism (GO:0031640)2.88304035
110disruption of cells of other organism (GO:0044364)2.88304035
111regulation of protein activation cascade (GO:2000257)2.88285969
112tryptophan catabolic process (GO:0006569)2.86989846
113indole-containing compound catabolic process (GO:0042436)2.86989846
114indolalkylamine catabolic process (GO:0046218)2.86989846
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.86820284
116heme metabolic process (GO:0042168)2.86329962
117positive regulation of receptor recycling (GO:0001921)2.84380893
118kynurenine metabolic process (GO:0070189)2.84267205
119tricarboxylic acid metabolic process (GO:0072350)2.84039912
120negative regulation of interleukin-17 production (GO:0032700)2.83573211
121homocysteine metabolic process (GO:0050667)2.82727623
122fatty acid beta-oxidation (GO:0006635)2.82000461
123angiotensin maturation (GO:0002003)2.81354719
124low-density lipoprotein particle clearance (GO:0034383)2.80191563
125porphyrin-containing compound metabolic process (GO:0006778)2.79529121
126fatty acid oxidation (GO:0019395)2.79049386
127positive regulation of mast cell activation involved in immune response (GO:0033008)2.77756510
128positive regulation of mast cell degranulation (GO:0043306)2.77756510
129carnitine metabolic process (GO:0009437)2.77290001
130response to interleukin-15 (GO:0070672)2.77145000
131negative regulation of T cell mediated immunity (GO:0002710)2.76085904
132UDP-N-acetylglucosamine metabolic process (GO:0006047)2.75107499
133regulation of complement activation (GO:0030449)2.74864929
134lipid oxidation (GO:0034440)2.74656896
135necroptotic process (GO:0070266)2.74457861
136regulation of cholesterol esterification (GO:0010872)2.74064227
137negative regulation of fibrinolysis (GO:0051918)2.74031334
138negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73269274
139G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.72939327
140negative regulation of phagocytosis (GO:0050765)2.72134032
141myeloid leukocyte mediated immunity (GO:0002444)2.71898304
142definitive hemopoiesis (GO:0060216)2.71748008
143positive regulation of gamma-delta T cell activation (GO:0046645)2.70720081
144immunoglobulin mediated immune response (GO:0016064)2.70306286
145myeloid cell development (GO:0061515)2.69319146
146thrombin receptor signaling pathway (GO:0070493)2.69269876
147negative regulation of leukocyte mediated immunity (GO:0002704)2.68320521
148regulation of B cell differentiation (GO:0045577)2.66703131
149dendritic cell migration (GO:0036336)2.66310747
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66249687
151negative regulation of T-helper cell differentiation (GO:0045623)2.66249687
152defense response to fungus (GO:0050832)2.64702869
153NADP metabolic process (GO:0006739)2.63992369
154drug transmembrane transport (GO:0006855)2.63942474
155neutrophil activation involved in immune response (GO:0002283)2.63770335
156oxaloacetate metabolic process (GO:0006107)2.63629839
157positive regulation of hemostasis (GO:1900048)2.63470178
158positive regulation of blood coagulation (GO:0030194)2.63470178
159leukocyte aggregation (GO:0070486)2.62537588
160positive regulation of macrophage differentiation (GO:0045651)2.62060519
161platelet aggregation (GO:0070527)2.60527697
162positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.60506289
163tetrapyrrole biosynthetic process (GO:0033014)2.60441317
164peptide catabolic process (GO:0043171)2.60221883
165lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59657949
166Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59483991
167antigen processing and presentation via MHC class Ib (GO:0002475)2.58480192
168regulation of T-helper 2 cell differentiation (GO:0045628)2.58295502
169fatty acid catabolic process (GO:0009062)2.57994608
170cellular modified amino acid catabolic process (GO:0042219)2.57696504
171positive regulation of lipid catabolic process (GO:0050996)2.57413453
172myeloid leukocyte activation (GO:0002274)2.55861047
173drug transport (GO:0015893)2.54864417
174oxygen transport (GO:0015671)2.54672975
175regulation of regulated secretory pathway (GO:1903305)2.53666410
176mannose metabolic process (GO:0006013)2.53640755
177regulation of cholesterol storage (GO:0010885)2.53307598
178regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53258800
179regulation of cholesterol metabolic process (GO:0090181)2.53002362
180dendritic cell chemotaxis (GO:0002407)2.52963034
181regulation of regulatory T cell differentiation (GO:0045589)2.52819346
182bile acid metabolic process (GO:0008206)2.51263515
183cellular response to thyroid hormone stimulus (GO:0097067)2.51192227
184regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51039440
185regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.50955850
186urate metabolic process (GO:0046415)2.50491431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.31800526
2E2F7_22180533_ChIP-Seq_HELA_Human4.10883416
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.54371626
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45067800
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.38615077
6GATA1_22025678_ChIP-Seq_K562_Human3.38288143
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25693343
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.09566264
9SCL_19346495_ChIP-Seq_HPC-7_Human2.91614087
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.90366478
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.83188980
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73632228
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.59568889
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59485436
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.48497572
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30444780
17SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.28917646
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28196548
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.25528740
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24725373
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19374641
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09980025
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.08342818
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06209240
25* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.02192904
26* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99090928
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.91945138
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91403134
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87084592
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.85590176
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83367085
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82037595
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80076201
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77946467
35VDR_21846776_ChIP-Seq_THP-1_Human1.76396219
36CLOCK_20551151_ChIP-Seq_293T_Human1.75883389
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73220343
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.71909348
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67203771
40VDR_24787735_ChIP-Seq_THP-1_Human1.66139351
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65978595
42AR_21909140_ChIP-Seq_LNCAP_Human1.65545117
43* GATA1_19941826_ChIP-Seq_K562_Human1.65297577
44SPI1_23547873_ChIP-Seq_NB4_Human1.64805062
45* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64565345
46* GATA1_19941827_ChIP-Seq_MEL_Mouse1.63457322
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62907627
48* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62029422
49* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60886481
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57200810
51MYB_26560356_Chip-Seq_TH2_Human1.51275683
52VDR_24763502_ChIP-Seq_THP-1_Human1.50188886
53* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46941176
54* RUNX1_22412390_ChIP-Seq_EML_Mouse1.43402607
55MYC_22102868_ChIP-Seq_BL_Human1.36892183
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36196766
57* GATA2_19941826_ChIP-Seq_K562_Human1.36150549
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34774062
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34426452
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34228167
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.33834554
62MAF_26560356_Chip-Seq_TH1_Human1.33560205
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32577341
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32471346
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31514046
66MYB_26560356_Chip-Seq_TH1_Human1.31426473
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31008920
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29535166
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26012417
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25237740
71* NCOR1_26117541_ChIP-Seq_K562_Human1.24396025
72* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23959707
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23280000
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.17364216
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17237921
76UTX_26944678_Chip-Seq_JUKART_Human1.16559857
77GATA1_19941827_ChIP-Seq_MEL86_Mouse1.16405425
78RUNX_20019798_ChIP-Seq_JUKART_Human1.16044789
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12968153
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12817814
81PU_27001747_Chip-Seq_BMDM_Mouse1.12332458
82* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12029093
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11458423
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09209632
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08228279
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05440540
87* TCF7_22412390_ChIP-Seq_EML_Mouse1.05030925
88* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04506153
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04340055
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04036410
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03460601
92SPI1_23127762_ChIP-Seq_K562_Human1.03427554
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02781339
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01996864
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01341616
96GATA3_27048872_Chip-Seq_THYMUS_Human0.99444239
97TFEB_21752829_ChIP-Seq_HELA_Human0.98876098
98* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98668758
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96491538
100* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95986052
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95739298
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92838165
103GATA4_25053715_ChIP-Seq_YYC3_Human0.92217814
104* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92058926
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91343118
106GATA3_26560356_Chip-Seq_TH2_Human0.91207037
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.90934364
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90893832
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.90485897
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90334506
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90264889
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.90257255
113KDM2B_26808549_Chip-Seq_DND41_Human0.89597750
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87943146
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.86793815
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86612188
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86437522
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86373710
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86290339
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85783127
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85340521
122MAF_26560356_Chip-Seq_TH2_Human0.85203360
123* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84749334
124* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83456297
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83145629
126ZNF263_19887448_ChIP-Seq_K562_Human0.81420905
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81331735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.98764498
2MP0002139_abnormal_hepatobiliary_system3.82082642
3MP0003656_abnormal_erythrocyte_physiolo3.54580685
4MP0005365_abnormal_bile_salt3.11480376
5MP0004147_increased_porphyrin_level3.04514400
6MP0003191_abnormal_cellular_cholesterol2.93888942
7MP0009840_abnormal_foam_cell2.76545992
8MP0005085_abnormal_gallbladder_physiolo2.74532294
9MP0008260_abnormal_autophagy2.59843555
10MP0008875_abnormal_xenobiotic_pharmacok2.50178261
11MP0005058_abnormal_lysosome_morphology2.46256015
12MP0010329_abnormal_lipoprotein_level2.41344005
13MP0005464_abnormal_platelet_physiology2.26859056
14MP0003828_pulmonary_edema2.25299122
15MP0005451_abnormal_body_composition2.23519535
16MP0008004_abnormal_stomach_pH2.14326290
17MP0003300_gastrointestinal_ulcer2.03169185
18MP0002166_altered_tumor_susceptibility1.98202927
19MP0002396_abnormal_hematopoietic_system1.97783280
20MP0001835_abnormal_antigen_presentation1.97762541
21MP0000465_gastrointestinal_hemorrhage1.92490973
22MP0001666_abnormal_nutrient_absorption1.89407098
23MP0003806_abnormal_nucleotide_metabolis1.84779552
24MP0003252_abnormal_bile_duct1.83501960
25MP0003172_abnormal_lysosome_physiology1.83169317
26MP0002419_abnormal_innate_immunity1.75963675
27MP0003436_decreased_susceptibility_to1.74402995
28MP0000609_abnormal_liver_physiology1.73951118
29MP0002132_abnormal_respiratory_system1.68620741
30MP0003763_abnormal_thymus_physiology1.54696966
31MP0003186_abnormal_redox_activity1.54438107
32MP0005332_abnormal_amino_acid1.54334842
33MP0000858_altered_metastatic_potential1.51436324
34MP0005083_abnormal_biliary_tract1.48591626
35MP0005025_abnormal_response_to1.46011741
36MP0002006_tumorigenesis1.44792779
37MP0003303_peritoneal_inflammation1.43817283
38MP0005319_abnormal_enzyme/_coenzyme1.43112933
39MP0009643_abnormal_urine_homeostasis1.42660935
40MP0005397_hematopoietic_system_phenotyp1.41644638
41MP0001545_abnormal_hematopoietic_system1.41644638
42MP0009785_altered_susceptibility_to1.41470838
43MP0005584_abnormal_enzyme/coenzyme_acti1.41189683
44MP0004883_abnormal_blood_vessel1.41132583
45MP0006054_spinal_hemorrhage1.40279764
46MP0009764_decreased_sensitivity_to1.39481452
47MP0002118_abnormal_lipid_homeostasis1.39473886
48MP0000685_abnormal_immune_system1.38205376
49MP0008469_abnormal_protein_level1.37005522
50MP0003183_abnormal_peptide_metabolism1.33622488
51MP0001853_heart_inflammation1.31710592
52MP0003866_abnormal_defecation1.31292721
53MP0004130_abnormal_muscle_cell1.31020178
54MP0001873_stomach_inflammation1.29681050
55MP0001851_eye_inflammation1.29311176
56MP0001764_abnormal_homeostasis1.26693002
57MP0002138_abnormal_hepatobiliary_system1.26069763
58MP0004510_myositis1.24943277
59MP0001845_abnormal_inflammatory_respons1.24748920
60MP0009278_abnormal_bone_marrow1.23268337
61MP0000598_abnormal_liver_morphology1.23068750
62MP0000604_amyloidosis1.23031532
63MP0005164_abnormal_response_to1.22681801
64MP0009333_abnormal_splenocyte_physiolog1.21895232
65MP0002998_abnormal_bone_remodeling1.20143750
66MP0002452_abnormal_antigen_presenting1.19514210
67MP0003724_increased_susceptibility_to1.18829954
68MP0000015_abnormal_ear_pigmentation1.18505158
69MP0005636_abnormal_mineral_homeostasis1.17940624
70MP0010352_gastrointestinal_tract_polyps1.17442043
71MP0004808_abnormal_hematopoietic_stem1.16227034
72MP0000689_abnormal_spleen_morphology1.15746772
73MP0005310_abnormal_salivary_gland1.15726188
74MP0010155_abnormal_intestine_physiology1.15403808
75MP0010307_abnormal_tumor_latency1.14866647
76MP0002398_abnormal_bone_marrow1.14304533
77MP0001800_abnormal_humoral_immune1.13529465
78MP0002420_abnormal_adaptive_immunity1.11170812
79MP0002723_abnormal_immune_serum1.10403002
80MP0001819_abnormal_immune_cell1.10385553
81MP0004381_abnormal_hair_follicle1.08792478
82MP0000703_abnormal_thymus_morphology1.08527973
83MP0009763_increased_sensitivity_to1.07132350
84MP0004264_abnormal_extraembryonic_tissu1.07111447
85MP0002722_abnormal_immune_system1.06933117
86MP0005387_immune_system_phenotype1.06822193
87MP0001790_abnormal_immune_system1.06822193
88MP0000569_abnormal_digit_pigmentation1.05209088
89MP0009697_abnormal_copulation1.04372642
90MP0005000_abnormal_immune_tolerance1.04200797
91MP0010234_abnormal_vibrissa_follicle1.03369605
92MP0002405_respiratory_system_inflammati1.03263911
93MP0002429_abnormal_blood_cell1.01922095
94MP0005671_abnormal_response_to1.01675529
95MP0000716_abnormal_immune_system1.00299231
96MP0004019_abnormal_vitamin_homeostasis0.99320330
97MP0000249_abnormal_blood_vessel0.99084242
98MP0000343_altered_response_to0.98659699
99MP0005409_darkened_coat_color0.98019102
100MP0003221_abnormal_cardiomyocyte_apopto0.96328059
101MP0004947_skin_inflammation0.95903572
102MP0002148_abnormal_hypersensitivity_rea0.94175261
103MP0001533_abnormal_skeleton_physiology0.93059371
104MP0001756_abnormal_urination0.92870507
105MP0004484_altered_response_of0.92783401
106MP0003091_abnormal_cell_migration0.91988929
107MP0002877_abnormal_melanocyte_morpholog0.91837105
108MP0005167_abnormal_blood-brain_barrier0.91288292
109MP0002136_abnormal_kidney_physiology0.90425412
110MP0002971_abnormal_brown_adipose0.89389401
111MP0003075_altered_response_to0.88465115
112MP0009765_abnormal_xenobiotic_induced0.87129729
113MP0004185_abnormal_adipocyte_glucose0.86886089
114MP0003448_altered_tumor_morphology0.86442638
115MP0003868_abnormal_feces_composition0.86185010
116MP0003690_abnormal_glial_cell0.84870619
117MP0003705_abnormal_hypodermis_morpholog0.84722456
118MP0000490_abnormal_crypts_of0.84336301
119MP0005647_abnormal_sex_gland0.83903406
120MP0003566_abnormal_cell_adhesion0.80999821
121MP0005666_abnormal_adipose_tissue0.80941824
122MP0005166_decreased_susceptibility_to0.80913628
123MP0006036_abnormal_mitochondrial_physio0.80808068
124MP0003453_abnormal_keratinocyte_physiol0.80239952
125MP0001915_intracranial_hemorrhage0.79741672
126MP0009115_abnormal_fat_cell0.79664216
127MP0002254_reproductive_system_inflammat0.78140618
128MP0008874_decreased_physiological_sensi0.78133651
129MP0006082_CNS_inflammation0.77484855
130MP0003195_calcinosis0.77127303
131MP0009642_abnormal_blood_homeostasis0.76721912
132MP0002332_abnormal_exercise_endurance0.74953647
133MP0001663_abnormal_digestive_system0.72958547
134MP0003795_abnormal_bone_structure0.66411791

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)4.60172143
2Acanthocytosis (HP:0001927)4.16341495
3Deep venous thrombosis (HP:0002625)3.67756268
4Abnormality of the heme biosynthetic pathway (HP:0010472)3.57606890
5Orchitis (HP:0100796)3.56721369
6Hypochromic microcytic anemia (HP:0004840)3.43133357
7Gastrointestinal infarctions (HP:0005244)3.43122124
8Retrobulbar optic neuritis (HP:0100654)3.41901515
9Optic neuritis (HP:0100653)3.41901515
10Xanthomatosis (HP:0000991)3.39726702
11Recurrent gram-negative bacterial infections (HP:0005420)3.32174936
12Vacuolated lymphocytes (HP:0001922)3.29966362
13Petechiae (HP:0000967)3.29067663
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23378227
15Hypobetalipoproteinemia (HP:0003563)3.23107890
16Complement deficiency (HP:0004431)3.19721021
17Intrahepatic cholestasis (HP:0001406)3.16918547
18Obstructive lung disease (HP:0006536)3.12208332
19Chronic obstructive pulmonary disease (HP:0006510)3.12208332
20Thrombocytosis (HP:0001894)3.10730094
21Abnormal platelet volume (HP:0011876)3.09300606
22Recurrent bacterial skin infections (HP:0005406)3.09082513
23Stomatitis (HP:0010280)3.09082143
24Increased mean platelet volume (HP:0011877)3.08914542
25Gingival bleeding (HP:0000225)3.08680656
26Increased cerebral lipofuscin (HP:0011813)3.04423406
27Recurrent abscess formation (HP:0002722)3.03688372
28Abnormality of the common coagulation pathway (HP:0010990)3.03335244
29Hyperbilirubinemia (HP:0002904)2.99489878
30Arterial thrombosis (HP:0004420)2.95519329
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94005861
32Abnormality of fatty-acid metabolism (HP:0004359)2.87157056
33Gingivitis (HP:0000230)2.85892485
34Autoimmune thrombocytopenia (HP:0001973)2.85261858
35Abnormal platelet function (HP:0011869)2.83183300
36Impaired platelet aggregation (HP:0003540)2.83183300
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81234542
38T lymphocytopenia (HP:0005403)2.79250695
39Eczematoid dermatitis (HP:0000976)2.79133559
40Cholelithiasis (HP:0001081)2.77245984
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.77158439
42Joint hemorrhage (HP:0005261)2.76250072
43Epistaxis (HP:0000421)2.74370174
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74341288
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71783774
46Encephalitis (HP:0002383)2.71440833
47Keratoconjunctivitis sicca (HP:0001097)2.71377309
48Elevated erythrocyte sedimentation rate (HP:0003565)2.70981097
49Chest pain (HP:0100749)2.70907243
50Prolonged bleeding time (HP:0003010)2.70114811
51Abnormality of the intrinsic pathway (HP:0010989)2.67813642
52Hyperammonemia (HP:0001987)2.66269906
53Abnormality of T cell number (HP:0011839)2.62337163
54Purpura (HP:0000979)2.60266725
55Abnormal gallbladder morphology (HP:0012437)2.59772109
56Urinary glycosaminoglycan excretion (HP:0003541)2.59118405
57Mucopolysacchariduria (HP:0008155)2.59118405
58Prolonged partial thromboplastin time (HP:0003645)2.58725147
59Systemic lupus erythematosus (HP:0002725)2.58263345
60Hypoglycemic coma (HP:0001325)2.56139277
61Meningitis (HP:0001287)2.53540313
62Menorrhagia (HP:0000132)2.51859156
63Vasculitis (HP:0002633)2.51190312
64Hypolipoproteinemia (HP:0010981)2.50511286
65Ketosis (HP:0001946)2.50144527
66Recurrent viral infections (HP:0004429)2.49544384
67Fat malabsorption (HP:0002630)2.49096520
68Hyperlipoproteinemia (HP:0010980)2.48775437
69Conjunctival telangiectasia (HP:0000524)2.48170978
70Spontaneous hematomas (HP:0007420)2.47920222
71IgM deficiency (HP:0002850)2.47595424
72Myocardial infarction (HP:0001658)2.47560786
73Abnormality of macrophages (HP:0004311)2.47438292
74Episodic fever (HP:0001954)2.44497260
75Abnormality of sulfur amino acid metabolism (HP:0004339)2.43201489
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43090002
77Keratoconjunctivitis (HP:0001096)2.41065685
78Peritonitis (HP:0002586)2.41004607
79Pulmonary embolism (HP:0002204)2.37107998
80Mediastinal lymphadenopathy (HP:0100721)2.36415039
81Dysostosis multiplex (HP:0000943)2.35003685
82Thrombophlebitis (HP:0004418)2.34679613
83Hyperglycinuria (HP:0003108)2.34470216
84Cellulitis (HP:0100658)2.33522125
85Leukocytosis (HP:0001974)2.32784494
86Abnormality of complement system (HP:0005339)2.30670533
87Hypercholesterolemia (HP:0003124)2.29390277
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27333531
89Abnormality of polysaccharide metabolism (HP:0011012)2.27333531
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27333531
91Recurrent skin infections (HP:0001581)2.26324465
92Bruising susceptibility (HP:0000978)2.25763238
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25744048
94Amyloidosis (HP:0011034)2.24307486
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.23345349
96Reticulocytosis (HP:0001923)2.23337392
97Inflammation of the large intestine (HP:0002037)2.21817245
98Epidermoid cyst (HP:0200040)2.21681987
99Abnormality of glycine metabolism (HP:0010895)2.21512439
100Abnormality of serine family amino acid metabolism (HP:0010894)2.21512439
101Osteomyelitis (HP:0002754)2.21050533
102Recurrent fungal infections (HP:0002841)2.20539157
103Chronic mucocutaneous candidiasis (HP:0002728)2.18345767
104Recurrent cutaneous fungal infections (HP:0011370)2.18345767
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18312950
106Autoimmune hemolytic anemia (HP:0001890)2.16762975
107Hypochromic anemia (HP:0001931)2.16757934
108Hepatosplenomegaly (HP:0001433)2.16225343
109Hepatocellular carcinoma (HP:0001402)2.15764755
110Hypertriglyceridemia (HP:0002155)2.15742978
111Periodontitis (HP:0000704)2.15720552
112Joint swelling (HP:0001386)2.14406722
113Increased serum ferritin (HP:0003281)2.13789736
114Microcytic anemia (HP:0001935)2.13413541
115Hypoalphalipoproteinemia (HP:0003233)2.10574989
116Nausea (HP:0002018)2.10077205
117Hemoptysis (HP:0002105)2.08997981
118Polycythemia (HP:0001901)2.08920694
119Pulmonary infiltrates (HP:0002113)2.08330648
120Gastrointestinal inflammation (HP:0004386)2.08261518
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07713138
122Urticaria (HP:0001025)2.06790301
123Abnormality of purine metabolism (HP:0004352)2.06013579
124Acute hepatic failure (HP:0006554)2.05938284
125Myositis (HP:0100614)2.05583356
126Abnormality of iron homeostasis (HP:0011031)2.05375884
127Granulocytopenia (HP:0001913)2.04424692
128Anorexia (HP:0002039)2.04400847
129Steatorrhea (HP:0002570)2.03947789
130Abnormal gallbladder physiology (HP:0012438)2.03603222
131Cholecystitis (HP:0001082)2.03603222
132Increased IgE level (HP:0003212)2.03213254
133Generalized aminoaciduria (HP:0002909)2.02511915
134Spastic diplegia (HP:0001264)2.02156930
135Hematochezia (HP:0002573)2.01151736
136Abnormality of the gallbladder (HP:0005264)2.00687832
137Pustule (HP:0200039)2.00108109
138Fatigue (HP:0012378)1.99753279
139Gangrene (HP:0100758)1.99625306
140Abnormality of transition element cation homeostasis (HP:0011030)1.99437956
141Spontaneous abortion (HP:0005268)1.98691679
142Chronic otitis media (HP:0000389)1.98212645
143Abnormality of nucleobase metabolism (HP:0010932)1.98027078
144Glomerulopathy (HP:0100820)1.95724883
145Nonimmune hydrops fetalis (HP:0001790)1.95165410
146Abnormality of T cells (HP:0002843)1.93935140
147Metabolic acidosis (HP:0001942)1.92832056
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.90374664
149Osteolytic defects of the hand bones (HP:0009699)1.90374664
150Vertigo (HP:0002321)1.90312751
151Paralysis (HP:0003470)1.89641232
152Hydroxyprolinuria (HP:0003080)1.89490084
153Increased IgM level (HP:0003496)1.88046394
154Slow saccadic eye movements (HP:0000514)1.82317615
155Colitis (HP:0002583)1.80351332
156Abnormality of glycosphingolipid metabolism (HP:0004343)1.79490689
157Abnormality of glycolipid metabolism (HP:0010969)1.79490689
158Abnormality of liposaccharide metabolism (HP:0010968)1.79490689
159Subacute progressive viral hepatitis (HP:0006572)1.77630357
160Eosinophilia (HP:0001880)1.76384355
161Viral hepatitis (HP:0006562)1.75455299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.01799423
2TAOK33.62992854
3EEF2K2.83686136
4ERN12.68557585
5TRIB32.59224430
6MAP4K12.55700307
7BCKDK2.53721305
8PKN22.51830397
9KIT2.25861232
10FLT32.25410492
11PRPF4B2.25054905
12STK102.23640835
13SCYL22.21331109
14FGR2.06250194
15TYK22.02587029
16NEK91.97058680
17EIF2AK11.95158992
18BMPR21.94515646
19FRK1.90571879
20JAK31.82419476
21LRRK21.72300677
22CAMK1D1.70265398
23OXSR11.67102752
24BTK1.65366051
25TGFBR21.61627966
26MAP2K31.58670239
27KSR21.56249657
28EPHB11.54662690
29CSF1R1.47926451
30FGFR41.39238485
31MAP3K11.39223261
32TEC1.37462442
33BMX1.36750095
34STK391.36394329
35IRAK41.34616744
36MAPK111.31972131
37YES11.30885176
38JAK21.29659966
39TBK11.29444635
40PTK2B1.28607206
41TAOK11.28405281
42ZAP701.25702970
43BRSK21.22077684
44TRPM71.22008373
45MAPKAPK31.19852106
46SYK1.18544193
47JAK11.18437475
48SIK11.18132914
49RIPK11.17448267
50MST41.16868433
51MATK1.15592874
52GRK61.14257092
53STK41.11510423
54MAP3K51.09929703
55TAOK21.09460379
56PTK61.06389803
57TGFBR11.04274577
58IRAK11.01383068
59MAP3K81.00036059
60CDK60.99595502
61TNK20.97474187
62MAP3K110.95921466
63PIM10.93914337
64MAP3K140.92309694
65PIK3CG0.91586006
66TTN0.91019454
67SGK20.88754512
68ITK0.85930758
69IKBKE0.85902327
70BLK0.85839873
71FES0.84369178
72MAP3K130.84356540
73PRKAA20.83555956
74EPHA30.82904392
75FGFR30.82752075
76CSK0.82608820
77RPS6KB20.81958386
78MARK30.81873939
79MAP3K60.81207372
80WNK10.76147235
81PAK40.74832435
82GRK50.74527095
83LMTK20.73841839
84PDK30.73005313
85PDK40.73005313
86ACVR1B0.69955504
87PDK10.69509282
88DYRK1B0.69420397
89STK30.68868053
90KSR10.68751387
91CDC70.67935803
92CAMKK20.66251571
93LYN0.65849468
94MARK20.64912193
95IRAK20.64089167
96CAMK1G0.63761097
97LCK0.63472096
98TESK20.62336764
99RET0.61116849
100MAPK120.59843195
101NEK20.59797991
102CDK120.58813734
103CDK40.58558613
104MAPKAPK50.58501138
105KDR0.57987382
106IRAK30.54726391
107FYN0.54281699
108HCK0.51063967
109HIPK20.49682990
110TIE10.49237902
111PDPK10.49177456
112PDK20.48861630
113PIM20.48855724
114NLK0.48599444
115EIF2AK30.46765608
116CDK90.46717298
117WEE10.44661096
118IKBKB0.43986257
119MYLK0.43530480
120ERBB20.42799933
121SIK30.41561890
122RPS6KA60.41412437
123PDGFRB0.41304124
124MAPK40.40035385
125MAP3K20.39650829
126CHUK0.39202203
127MAP3K30.38746714
128MAP2K40.37798991
129TXK0.37289702
130RPS6KA40.36974684
131EGFR0.36654682
132STK240.36526942
133RAF10.35849185
134MAPKAPK20.35559077
135PRKD10.35192808
136SGK30.34615549
137PRKCQ0.32464257

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.21558569
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.79065800
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52649287
4Fatty acid degradation_Homo sapiens_hsa000712.47503524
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.26665315
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16659007
7Caffeine metabolism_Homo sapiens_hsa002322.16383774
8Complement and coagulation cascades_Homo sapiens_hsa046102.16337959
9Propanoate metabolism_Homo sapiens_hsa006402.10587478
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99615852
11Staphylococcus aureus infection_Homo sapiens_hsa051501.99612590
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99217425
13Arginine biosynthesis_Homo sapiens_hsa002201.96887493
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95854955
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91834740
16Tryptophan metabolism_Homo sapiens_hsa003801.87480516
17PPAR signaling pathway_Homo sapiens_hsa033201.83993355
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83775721
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80373025
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78248533
21Selenocompound metabolism_Homo sapiens_hsa004501.76418648
22Peroxisome_Homo sapiens_hsa041461.73133401
23Fatty acid metabolism_Homo sapiens_hsa012121.71823705
24Non-small cell lung cancer_Homo sapiens_hsa052231.71405695
25Vitamin B6 metabolism_Homo sapiens_hsa007501.65673913
26Chemokine signaling pathway_Homo sapiens_hsa040621.62027994
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61976040
28Renin-angiotensin system_Homo sapiens_hsa046141.57206067
29Other glycan degradation_Homo sapiens_hsa005111.56230147
30ABC transporters_Homo sapiens_hsa020101.53553123
31T cell receptor signaling pathway_Homo sapiens_hsa046601.47222138
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45741906
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43803613
34Pyruvate metabolism_Homo sapiens_hsa006201.43245533
35Pentose phosphate pathway_Homo sapiens_hsa000301.42979773
36Starch and sucrose metabolism_Homo sapiens_hsa005001.42092403
37Carbon metabolism_Homo sapiens_hsa012001.39446494
38beta-Alanine metabolism_Homo sapiens_hsa004101.39000439
39Phagosome_Homo sapiens_hsa041451.35432924
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.34746218
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.33874520
42Histidine metabolism_Homo sapiens_hsa003401.33589391
43Graft-versus-host disease_Homo sapiens_hsa053321.31650260
44Chronic myeloid leukemia_Homo sapiens_hsa052201.31274862
45Allograft rejection_Homo sapiens_hsa053301.28645261
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.27727431
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.25243371
48Sulfur metabolism_Homo sapiens_hsa009201.23808764
49Lysosome_Homo sapiens_hsa041421.21877090
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19346943
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18832438
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.17520505
53Biosynthesis of amino acids_Homo sapiens_hsa012301.17417794
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16873555
55Autoimmune thyroid disease_Homo sapiens_hsa053201.13492946
56Folate biosynthesis_Homo sapiens_hsa007901.13158349
57Fat digestion and absorption_Homo sapiens_hsa049751.11549097
58Hepatitis B_Homo sapiens_hsa051611.09770997
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09469848
60Renal cell carcinoma_Homo sapiens_hsa052111.07258019
61Butanoate metabolism_Homo sapiens_hsa006501.04952987
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03334668
63TNF signaling pathway_Homo sapiens_hsa046681.03113258
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00540887
65Shigellosis_Homo sapiens_hsa051311.00233304
66Endometrial cancer_Homo sapiens_hsa052130.99787588
67Vitamin digestion and absorption_Homo sapiens_hsa049770.96106412
68Leishmaniasis_Homo sapiens_hsa051400.95064702
69Systemic lupus erythematosus_Homo sapiens_hsa053220.93502105
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93345274
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91639097
72VEGF signaling pathway_Homo sapiens_hsa043700.90107453
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89891917
74Primary immunodeficiency_Homo sapiens_hsa053400.89596918
75Viral myocarditis_Homo sapiens_hsa054160.86726080
76Amoebiasis_Homo sapiens_hsa051460.86667488
77Bile secretion_Homo sapiens_hsa049760.85798866
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84978454
79Chemical carcinogenesis_Homo sapiens_hsa052040.84822043
80Prolactin signaling pathway_Homo sapiens_hsa049170.84803076
81Fatty acid elongation_Homo sapiens_hsa000620.84185949
82Endocytosis_Homo sapiens_hsa041440.83601647
83Antigen processing and presentation_Homo sapiens_hsa046120.83502005
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83448790
85FoxO signaling pathway_Homo sapiens_hsa040680.83135980
86African trypanosomiasis_Homo sapiens_hsa051430.82159442
87Glutathione metabolism_Homo sapiens_hsa004800.81254505
88Type I diabetes mellitus_Homo sapiens_hsa049400.81063955
89Salmonella infection_Homo sapiens_hsa051320.80958560
90Glycerolipid metabolism_Homo sapiens_hsa005610.80299339
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.79190223
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78963330
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78639752
94Lysine degradation_Homo sapiens_hsa003100.77701590
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75725663
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74697321
97Sulfur relay system_Homo sapiens_hsa041220.73904468
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73756864
99Asthma_Homo sapiens_hsa053100.72490204
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.71598220
101Choline metabolism in cancer_Homo sapiens_hsa052310.70706465
102HIF-1 signaling pathway_Homo sapiens_hsa040660.70349333
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.70167415
104Insulin resistance_Homo sapiens_hsa049310.69507623
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.67869324
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67476117
107Inositol phosphate metabolism_Homo sapiens_hsa005620.66650742
108Osteoclast differentiation_Homo sapiens_hsa043800.66038476
109Rheumatoid arthritis_Homo sapiens_hsa053230.65736476
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65650213
111Fatty acid biosynthesis_Homo sapiens_hsa000610.64923888
112Fructose and mannose metabolism_Homo sapiens_hsa000510.64446550
113Galactose metabolism_Homo sapiens_hsa000520.64065139
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.63888078
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63867327
116mTOR signaling pathway_Homo sapiens_hsa041500.63677707
117Glioma_Homo sapiens_hsa052140.62629731
118Legionellosis_Homo sapiens_hsa051340.61731325
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60059486
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59397472
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59213218
122Phenylalanine metabolism_Homo sapiens_hsa003600.59030691
123Retinol metabolism_Homo sapiens_hsa008300.58860994
124N-Glycan biosynthesis_Homo sapiens_hsa005100.58260324
125B cell receptor signaling pathway_Homo sapiens_hsa046620.57880507
126Hematopoietic cell lineage_Homo sapiens_hsa046400.57121534
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.56992262
128Toxoplasmosis_Homo sapiens_hsa051450.55773397
129Prostate cancer_Homo sapiens_hsa052150.54621621
130One carbon pool by folate_Homo sapiens_hsa006700.54405158
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54307996
132Dorso-ventral axis formation_Homo sapiens_hsa043200.53263472
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52636957
134Small cell lung cancer_Homo sapiens_hsa052220.52372792
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51974736
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51321094
137Arachidonic acid metabolism_Homo sapiens_hsa005900.51009779
138GnRH signaling pathway_Homo sapiens_hsa049120.49874021
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48965841
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.48905432
141Platelet activation_Homo sapiens_hsa046110.47984910
142Measles_Homo sapiens_hsa051620.47831639
143Insulin signaling pathway_Homo sapiens_hsa049100.47412456
144ErbB signaling pathway_Homo sapiens_hsa040120.46817073
145Pertussis_Homo sapiens_hsa051330.45934439
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44555853
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42184784
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.41754571
149Tuberculosis_Homo sapiens_hsa051520.41264566
150Pancreatic cancer_Homo sapiens_hsa052120.41084830
151Apoptosis_Homo sapiens_hsa042100.40733025
152DNA replication_Homo sapiens_hsa030300.37812340
153Hepatitis C_Homo sapiens_hsa051600.37740313
154Influenza A_Homo sapiens_hsa051640.37115463
155Acute myeloid leukemia_Homo sapiens_hsa052210.36622363
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36228420
157Tyrosine metabolism_Homo sapiens_hsa003500.35544995
158Herpes simplex infection_Homo sapiens_hsa051680.35161228
159Viral carcinogenesis_Homo sapiens_hsa052030.35137288
160Malaria_Homo sapiens_hsa051440.34743189
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32972431

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