NCOA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)4.93287448
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.80321343
3pre-miRNA processing (GO:0031054)4.80231165
4negative regulation of RNA splicing (GO:0033119)4.20875148
5peptidyl-lysine dimethylation (GO:0018027)3.95379655
6COPI coating of Golgi vesicle (GO:0048205)3.91726245
7Golgi transport vesicle coating (GO:0048200)3.91726245
8negative regulation of mRNA processing (GO:0050686)3.84131701
9DNA topological change (GO:0006265)3.79894608
10protein-DNA complex disassembly (GO:0032986)3.78123593
11nucleosome disassembly (GO:0006337)3.78123593
12establishment of integrated proviral latency (GO:0075713)3.71864885
13negative regulation of histone methylation (GO:0031061)3.68144662
14mRNA stabilization (GO:0048255)3.63528285
15RNA stabilization (GO:0043489)3.63528285
16regulation of NFAT protein import into nucleus (GO:0051532)3.58320817
17regulation of translational fidelity (GO:0006450)3.58068528
18glucocorticoid receptor signaling pathway (GO:0042921)3.57685179
19dosage compensation (GO:0007549)3.55471384
20negative regulation of mRNA metabolic process (GO:1903312)3.52310181
21histone H3-K36 demethylation (GO:0070544)3.49254391
22DNA unwinding involved in DNA replication (GO:0006268)3.48893113
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.39191638
24mitotic metaphase plate congression (GO:0007080)3.36337095
253-UTR-mediated mRNA stabilization (GO:0070935)3.35494655
26establishment of viral latency (GO:0019043)3.21394641
27heterochromatin organization (GO:0070828)3.20130411
28regulation of RNA export from nucleus (GO:0046831)3.18638729
29protein complex localization (GO:0031503)3.18623676
30mitotic sister chromatid cohesion (GO:0007064)3.14764596
31positive regulation of RNA splicing (GO:0033120)3.13273526
32RNA localization (GO:0006403)3.12635192
33layer formation in cerebral cortex (GO:0021819)3.08349637
34cellular protein complex localization (GO:0034629)3.07150433
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.06706939
36regulation of transcription from RNA polymerase I promoter (GO:0006356)3.03638132
37intracellular estrogen receptor signaling pathway (GO:0030520)3.01719577
38NLS-bearing protein import into nucleus (GO:0006607)2.99070103
39peptidyl-arginine omega-N-methylation (GO:0035247)2.98355433
40protein localization to microtubule (GO:0035372)2.96723922
41pore complex assembly (GO:0046931)2.96565144
42cellular hyperosmotic response (GO:0071474)2.95467585
43regulation of chromatin binding (GO:0035561)2.94519268
44positive regulation of histone deacetylation (GO:0031065)2.93304788
45regulation of sister chromatid cohesion (GO:0007063)2.92168385
46protein localization to chromosome (GO:0034502)2.90685505
47histone H2B ubiquitination (GO:0033523)2.89293287
48mRNA splice site selection (GO:0006376)2.86525758
49regulation of mRNA stability (GO:0043488)2.86115331
50translesion synthesis (GO:0019985)2.85754273
51regulation of histone H3-K9 methylation (GO:0051570)2.85136281
52corticosteroid receptor signaling pathway (GO:0031958)2.85059121
53peptidyl-arginine methylation (GO:0018216)2.84256105
54peptidyl-arginine N-methylation (GO:0035246)2.84256105
55planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83715579
56histone arginine methylation (GO:0034969)2.82310023
57regulation of spindle organization (GO:0090224)2.81569108
58protein localization to endosome (GO:0036010)2.81303708
59negative regulation of gene expression, epigenetic (GO:0045814)2.80769241
60negative regulation of cell size (GO:0045792)2.80590004
61nuclear envelope organization (GO:0006998)2.80421456
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80356027
63mitotic G1 DNA damage checkpoint (GO:0031571)2.79895625
64positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.79402785
65DNA strand elongation (GO:0022616)2.78666858
66V(D)J recombination (GO:0033151)2.77682751
67negative regulation of microtubule polymerization (GO:0031115)2.76514384
68DNA duplex unwinding (GO:0032508)2.75450636
69chromosome condensation (GO:0030261)2.75013665
70glial cell proliferation (GO:0014009)2.73758635
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73001484
72DNA strand elongation involved in DNA replication (GO:0006271)2.72656895
73regulation of mitotic spindle organization (GO:0060236)2.72650889
74regulation of RNA stability (GO:0043487)2.72177403
75nuclear pore complex assembly (GO:0051292)2.70925937
76DNA geometric change (GO:0032392)2.70269314
77gene silencing (GO:0016458)2.69063793
78protein localization to chromosome, centromeric region (GO:0071459)2.67858552
79protein localization to kinetochore (GO:0034501)2.67857782
80sister chromatid segregation (GO:0000819)2.67667825
81RNA splicing, via transesterification reactions (GO:0000375)2.64781910
82stress granule assembly (GO:0034063)2.64488568
83NIK/NF-kappaB signaling (GO:0038061)2.64044312
84regulation of nucleobase-containing compound transport (GO:0032239)2.62072937
85positive regulation of chromosome segregation (GO:0051984)2.61904634
86positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.61376072
87regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.61376072
88chromatin silencing (GO:0006342)2.60038480
89positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.59919189
90cell migration in hindbrain (GO:0021535)2.58612504
91gene silencing by RNA (GO:0031047)2.58069014
92regulation of translational termination (GO:0006449)2.57059415
93nuclear pore organization (GO:0006999)2.56083333
94regulation of DNA damage checkpoint (GO:2000001)2.55294194
95histone H2A monoubiquitination (GO:0035518)2.54783748
96cytoplasmic mRNA processing body assembly (GO:0033962)2.54372497
97mitotic nuclear envelope disassembly (GO:0007077)2.53741543
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53692391
99membrane disassembly (GO:0030397)2.53230621
100nuclear envelope disassembly (GO:0051081)2.53230621
101mRNA export from nucleus (GO:0006406)2.52786530
102DNA replication initiation (GO:0006270)2.51109953
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48314556
104negative regulation of erythrocyte differentiation (GO:0045647)2.47068335
105cellular response to epidermal growth factor stimulus (GO:0071364)2.46855483
106negative regulation of histone modification (GO:0031057)2.46443833
107histone H4-K16 acetylation (GO:0043984)2.46155944
108adherens junction assembly (GO:0034333)2.44892699
109negative regulation of cell killing (GO:0031342)2.44159265
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44159265
111metaphase plate congression (GO:0051310)2.44049895
112activation of Rac GTPase activity (GO:0032863)2.42599355
113positive regulation of DNA-templated transcription, elongation (GO:0032786)2.42233277
114establishment of nucleus localization (GO:0040023)2.41759406
115establishment of chromosome localization (GO:0051303)2.40724120
116termination of RNA polymerase II transcription (GO:0006369)2.40582796
117apoptotic process involved in morphogenesis (GO:0060561)2.40536137
118RNA export from nucleus (GO:0006405)2.40458887
119trophoblast giant cell differentiation (GO:0060707)2.39846990
120negative regulation of histone acetylation (GO:0035067)2.38475119
121alternative mRNA splicing, via spliceosome (GO:0000380)2.37956457
122chromatin assembly (GO:0031497)2.37579354
123regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.37482418
124regulation of double-strand break repair (GO:2000779)2.37445995
125histone H4-K8 acetylation (GO:0043982)2.36589742
126histone H4-K5 acetylation (GO:0043981)2.36589742
127positive regulation of synapse maturation (GO:0090129)2.35261623
128positive regulation of gene expression, epigenetic (GO:0045815)2.34802574
129maternal placenta development (GO:0001893)2.32428810
130mRNA cleavage (GO:0006379)2.32399026
131ectodermal placode formation (GO:0060788)2.32295100
132signal complex assembly (GO:0007172)2.30643313
133activation of JUN kinase activity (GO:0007257)2.30305930
134regulation of protein heterodimerization activity (GO:0043497)2.30262163
135positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.29789975
136regulation of ARF GTPase activity (GO:0032312)2.28601711
137histone mRNA catabolic process (GO:0071044)2.28301656
138G1 DNA damage checkpoint (GO:0044783)2.25076047
139mRNA transport (GO:0051028)2.24128065
140RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.23874254
141mRNA splicing, via spliceosome (GO:0000398)2.23874254
142regulation of gamma-delta T cell differentiation (GO:0045586)2.23855069
143regulation of histone H3-K4 methylation (GO:0051569)2.22769649
144nodal signaling pathway (GO:0038092)2.22714143
145mitotic sister chromatid segregation (GO:0000070)2.21961609
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.20771184
147morphogenesis of an endothelium (GO:0003159)2.20706226
148endothelial tube morphogenesis (GO:0061154)2.20706226
149insulin-like growth factor receptor signaling pathway (GO:0048009)2.17643417
150negative regulation of chromatin modification (GO:1903309)2.17332467
151mitotic G1/S transition checkpoint (GO:0044819)2.16696984
152body morphogenesis (GO:0010171)2.16649935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.38054679
2MYC_22102868_ChIP-Seq_BL_Human4.25225662
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.89472780
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.88829101
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23825318
6VDR_21846776_ChIP-Seq_THP-1_Human3.09332680
7KDM2B_26808549_Chip-Seq_DND41_Human2.65263935
8TCF7_22412390_ChIP-Seq_EML_Mouse2.65165563
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.45113532
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41967563
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41609826
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.40081225
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.31268474
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26031986
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19993857
16* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18190238
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14698260
18CIITA_25753668_ChIP-Seq_RAJI_Human2.04730839
19ZFP281_27345836_Chip-Seq_ESCs_Mouse2.03417580
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99402343
21KDM2B_26808549_Chip-Seq_JURKAT_Human1.92376091
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.90956929
23LXR_22292898_ChIP-Seq_THP-1_Human1.90357445
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.86780033
25UTX_26944678_Chip-Seq_JUKART_Human1.85288616
26AR_21909140_ChIP-Seq_LNCAP_Human1.82995134
27* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75594355
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73674725
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71613814
30KDM2B_26808549_Chip-Seq_K562_Human1.70766815
31MAF_26560356_Chip-Seq_TH1_Human1.70536597
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.68174008
33VDR_24763502_ChIP-Seq_THP-1_Human1.62185161
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61555127
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58104027
36* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57805047
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55898348
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54332439
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54014170
40* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53749229
41* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52128485
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52126811
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50630153
44* MYC_18555785_ChIP-Seq_MESCs_Mouse1.50243288
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49948591
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47797521
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.47297292
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45914938
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44911750
50* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44581841
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43248938
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41250859
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41068031
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.39273707
55CLOCK_20551151_ChIP-Seq_293T_Human1.37705772
56* GABP_19822575_ChIP-Seq_HepG2_Human1.37304419
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.36971190
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35393296
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34745528
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33942069
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32186363
62* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31143352
63XRN2_22483619_ChIP-Seq_HELA_Human1.30890457
64DCP1A_22483619_ChIP-Seq_HELA_Human1.30449268
65MAF_26560356_Chip-Seq_TH2_Human1.29120740
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27929336
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27550332
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27277557
69SCL_19346495_ChIP-Seq_HPC-7_Human1.26546741
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25997955
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25617635
72CREB1_26743006_Chip-Seq_LNCaP_Human1.25341475
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.23620230
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23485814
75RACK7_27058665_Chip-Seq_MCF-7_Human1.21218056
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20232961
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20211687
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19178516
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18872223
80NCOR1_26117541_ChIP-Seq_K562_Human1.17551630
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15540934
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15476416
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15415985
84TFEB_21752829_ChIP-Seq_HELA_Human1.15258761
85KDM5A_27292631_Chip-Seq_BREAST_Human1.14961926
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14885385
87ZNF263_19887448_ChIP-Seq_K562_Human1.13071003
88P68_20966046_ChIP-Seq_HELA_Human1.12575355
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12284015
90MYB_26560356_Chip-Seq_TH1_Human1.11343450
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10839670
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10507895
93SPI1_23127762_ChIP-Seq_K562_Human1.09884803
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09401823
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09144283
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09054935
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09037705
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09005726
99* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08342352
100CHD1_26751641_Chip-Seq_LNCaP_Human1.07960390
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07467952
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07114763
103* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06894911
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06470346
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06469942
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06197759
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05425739
108* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05286683
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.05174793
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.04566757
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04113359
112MYB_26560356_Chip-Seq_TH2_Human1.02866544
113* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02336133
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02290395
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.01514755
116TP53_22127205_ChIP-Seq_IMR90_Human1.00754747
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00591051
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00194307
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.99814593
120* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99710092
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99136256
122TTF2_22483619_ChIP-Seq_HELA_Human0.98535538
123JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98219095
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97840575
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97319121
126SMC4_20622854_ChIP-Seq_HELA_Human0.96371456
127* ATF3_27146783_Chip-Seq_COLON_Human0.95416418
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95203380
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94296474
130* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93648127
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92777449
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92612300
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92097420
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91784113
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.91254575
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91130207
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88649540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.14079045
2MP0003123_paternal_imprinting3.04061101
3MP0009278_abnormal_bone_marrow2.83586830
4MP0005076_abnormal_cell_differentiation2.82002533
5MP0000537_abnormal_urethra_morphology2.63251718
6MP0003705_abnormal_hypodermis_morpholog2.61348755
7MP0010352_gastrointestinal_tract_polyps2.47568741
8MP0000569_abnormal_digit_pigmentation2.34696746
9MP0008961_abnormal_basal_metabolism2.13649220
10MP0001346_abnormal_lacrimal_gland2.11886449
11MP0003111_abnormal_nucleus_morphology2.04477318
12MP0003303_peritoneal_inflammation2.00470380
13MP0004808_abnormal_hematopoietic_stem1.99730866
14MP0003300_gastrointestinal_ulcer1.99621766
15MP0004859_abnormal_synaptic_plasticity1.97242127
16MP0004185_abnormal_adipocyte_glucose1.97160746
17MP0003121_genomic_imprinting1.90762709
18MP0002653_abnormal_ependyma_morphology1.84928826
19MP0010094_abnormal_chromosome_stability1.83269880
20MP0003119_abnormal_digestive_system1.79166045
21MP0003077_abnormal_cell_cycle1.78556028
22MP0002009_preneoplasia1.78237250
23MP0004264_abnormal_extraembryonic_tissu1.72014674
24MP0003283_abnormal_digestive_organ1.69132245
25MP0000350_abnormal_cell_proliferation1.62052725
26MP0004197_abnormal_fetal_growth/weight/1.61384673
27MP0008057_abnormal_DNA_replication1.60773875
28MP0001730_embryonic_growth_arrest1.60286014
29MP0008932_abnormal_embryonic_tissue1.59463037
30MP0002084_abnormal_developmental_patter1.59075059
31MP0003787_abnormal_imprinting1.58700230
32MP0008260_abnormal_autophagy1.53926572
33MP0002877_abnormal_melanocyte_morpholog1.52760106
34MP0003122_maternal_imprinting1.50287483
35MP0005397_hematopoietic_system_phenotyp1.49748973
36MP0001545_abnormal_hematopoietic_system1.49748973
37MP0005058_abnormal_lysosome_morphology1.49013163
38MP0001348_abnormal_lacrimal_gland1.48489535
39MP0010307_abnormal_tumor_latency1.47202470
40MP0000685_abnormal_immune_system1.46191537
41MP0004957_abnormal_blastocyst_morpholog1.45791969
42MP0008058_abnormal_DNA_repair1.44411138
43MP0004858_abnormal_nervous_system1.42573190
44MP0000703_abnormal_thymus_morphology1.41454675
45MP0002085_abnormal_embryonic_tissue1.40939072
46MP0000428_abnormal_craniofacial_morphol1.38519318
47MP0003693_abnormal_embryo_hatching1.36532043
48MP0002086_abnormal_extraembryonic_tissu1.36184650
49MP0001849_ear_inflammation1.34426700
50MP0005380_embryogenesis_phenotype1.32812350
51MP0001672_abnormal_embryogenesis/_devel1.32812350
52MP0001697_abnormal_embryo_size1.32607560
53MP0004233_abnormal_muscle_weight1.31545720
54MP0002396_abnormal_hematopoietic_system1.31463316
55MP0002234_abnormal_pharynx_morphology1.31391735
56MP0003453_abnormal_keratinocyte_physiol1.28888504
57MP0005174_abnormal_tail_pigmentation1.28723841
58MP0002088_abnormal_embryonic_growth/wei1.26453272
59MP0000733_abnormal_muscle_development1.25174556
60MP0002080_prenatal_lethality1.25036301
61MP0003984_embryonic_growth_retardation1.24891016
62MP0009333_abnormal_splenocyte_physiolog1.23708683
63MP0008007_abnormal_cellular_replicative1.23478686
64MP0003861_abnormal_nervous_system1.22779642
65MP0009053_abnormal_anal_canal1.22458600
66MP0008877_abnormal_DNA_methylation1.18220930
67MP0001293_anophthalmia1.18023762
68MP0002398_abnormal_bone_marrow1.17978624
69MP0005621_abnormal_cell_physiology1.17433354
70MP0008770_decreased_survivor_rate1.14241231
71MP0005187_abnormal_penis_morphology1.13839457
72MP0003942_abnormal_urinary_system1.12695848
73MP0003943_abnormal_hepatobiliary_system1.11426328
74MP0003763_abnormal_thymus_physiology1.11275240
75MP0003115_abnormal_respiratory_system1.11089786
76MP0005623_abnormal_meninges_morphology1.11018705
77MP0000490_abnormal_crypts_of1.10361397
78MP0003935_abnormal_craniofacial_develop1.09775105
79MP0002089_abnormal_postnatal_growth/wei1.09374626
80MP0004811_abnormal_neuron_physiology1.09347622
81MP0010030_abnormal_orbit_morphology1.08976552
82MP0001216_abnormal_epidermal_layer1.08774543
83MP0005501_abnormal_skin_physiology1.08533143
84MP0002796_impaired_skin_barrier1.08462937
85MP0003436_decreased_susceptibility_to1.07007934
86MP0002249_abnormal_larynx_morphology1.05044729
87MP0003566_abnormal_cell_adhesion1.03672564
88MP0004947_skin_inflammation1.02781460
89MP0003315_abnormal_perineum_morphology1.02081589
90MP0003191_abnormal_cellular_cholesterol1.01801163
91MP0009703_decreased_birth_body0.99710099
92MP0005384_cellular_phenotype0.98800275
93MP0000313_abnormal_cell_death0.98703403
94MP0006054_spinal_hemorrhage0.97347670
95MP0000858_altered_metastatic_potential0.96110848
96MP0009672_abnormal_birth_weight0.94987619
97MP0005310_abnormal_salivary_gland0.94886916
98MP0002925_abnormal_cardiovascular_devel0.94837502
99MP0003221_abnormal_cardiomyocyte_apopto0.91386886
100MP0003567_abnormal_fetal_cardiomyocyte0.91235848
101MP0005394_taste/olfaction_phenotype0.91150162
102MP0005499_abnormal_olfactory_system0.91150162
103MP0003385_abnormal_body_wall0.89953579
104MP0002098_abnormal_vibrissa_morphology0.89310266
105MP0002932_abnormal_joint_morphology0.88529948
106MP0000534_abnormal_ureter_morphology0.88255079
107MP0000377_abnormal_hair_follicle0.88240878
108MP0002092_abnormal_eye_morphology0.88184404
109MP0010234_abnormal_vibrissa_follicle0.87418543
110MP0000566_synostosis0.86892687
111MP0004510_myositis0.86797427
112MP0003890_abnormal_embryonic-extraembry0.86280862
113MP0002019_abnormal_tumor_incidence0.84480940
114MP0002152_abnormal_brain_morphology0.84307658
115MP0002722_abnormal_immune_system0.84151469
116MP0003091_abnormal_cell_migration0.83920194
117MP0002909_abnormal_adrenal_gland0.83889408
118MP0001727_abnormal_embryo_implantation0.83749342
119MP0001915_intracranial_hemorrhage0.82751212
120MP0006072_abnormal_retinal_apoptosis0.82018284
121MP0000678_abnormal_parathyroid_gland0.81954096
122MP0002081_perinatal_lethality0.81692347
123MP0003938_abnormal_ear_development0.79326592
124MP0000003_abnormal_adipose_tissue0.78508531
125MP0002111_abnormal_tail_morphology0.78446071
126MP0002166_altered_tumor_susceptibility0.78370267
127MP0002116_abnormal_craniofacial_bone0.76568049
128MP0002970_abnormal_white_adipose0.75929882
129MP0000432_abnormal_head_morphology0.75578236
130MP0005257_abnormal_intraocular_pressure0.74989055
131MP0000778_abnormal_nervous_system0.74758327
132MP0000689_abnormal_spleen_morphology0.74718339
133MP0000955_abnormal_spinal_cord0.74645897
134MP0002282_abnormal_trachea_morphology0.74541203
135MP0008789_abnormal_olfactory_epithelium0.73670403
136MP0002405_respiratory_system_inflammati0.72958959
137MP0001270_distended_abdomen0.72012103
138MP0010630_abnormal_cardiac_muscle0.71600027

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.25253281
2Cortical dysplasia (HP:0002539)3.73262566
3High anterior hairline (HP:0009890)3.66229391
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.37455491
5Short 4th metacarpal (HP:0010044)3.37455491
6Renal duplication (HP:0000075)3.36120262
7Elfin facies (HP:0004428)3.18743554
8Insomnia (HP:0100785)3.03562137
9Subacute progressive viral hepatitis (HP:0006572)3.01913427
10Renovascular hypertension (HP:0100817)2.86952000
11Shoulder girdle muscle weakness (HP:0003547)2.83704389
12Pointed chin (HP:0000307)2.83683208
13Abnormality of the distal phalanx of the thumb (HP:0009617)2.83288530
14Long palpebral fissure (HP:0000637)2.78169687
15Overriding aorta (HP:0002623)2.70377800
16Macroorchidism (HP:0000053)2.68742197
17Abnormality of the 4th metacarpal (HP:0010012)2.68428651
18Abnormality of the lower motor neuron (HP:0002366)2.67399977
19Abnormality of the phalanges of the hallux (HP:0010057)2.63873330
20Increased nuchal translucency (HP:0010880)2.60897556
21Cerebral aneurysm (HP:0004944)2.59829164
22Shallow orbits (HP:0000586)2.55398895
23Ependymoma (HP:0002888)2.50701973
24Abnormality of the astrocytes (HP:0100707)2.45991890
25Astrocytoma (HP:0009592)2.45991890
26Bowel diverticulosis (HP:0005222)2.44866967
27Heterotopia (HP:0002282)2.39856922
28Annular pancreas (HP:0001734)2.39781780
29Short nail (HP:0001799)2.37914894
30Microvesicular hepatic steatosis (HP:0001414)2.37428399
31Pelvic girdle muscle weakness (HP:0003749)2.33623210
32Increased density of long bones (HP:0006392)2.32894158
33Ankyloglossia (HP:0010296)2.25796847
34Flat cornea (HP:0007720)2.21215896
35Viral hepatitis (HP:0006562)2.17723529
36Asymmetry of the thorax (HP:0001555)2.16038732
37Back pain (HP:0003418)2.14851717
38Abnormality of the musculature of the pelvis (HP:0001469)2.14799014
39Abnormality of the hip-girdle musculature (HP:0001445)2.14799014
40Amyotrophic lateral sclerosis (HP:0007354)2.13522144
41Deep philtrum (HP:0002002)2.13424103
42Progressive muscle weakness (HP:0003323)2.12987473
43Papilledema (HP:0001085)2.12647835
44Peripheral hypomyelination (HP:0007182)2.11809834
45Abnormality of oral frenula (HP:0000190)2.07184614
46Septate vagina (HP:0001153)2.06540030
47Colon cancer (HP:0003003)2.06325628
48Hallux valgus (HP:0001822)2.04158696
49Trigonocephaly (HP:0000243)2.03988858
50Abnormality of the fingertips (HP:0001211)2.03922450
51Overlapping toe (HP:0001845)2.03273564
52Fibrous tissue neoplasm (HP:0012316)2.02148895
53Basal cell carcinoma (HP:0002671)2.02144299
54Neoplasm of the heart (HP:0100544)2.00391912
55Deviation of the hallux (HP:0010051)2.00287574
56Medulloblastoma (HP:0002885)1.99541465
57Obsessive-compulsive behavior (HP:0000722)1.99317141
58Bicuspid aortic valve (HP:0001647)1.96665102
59Volvulus (HP:0002580)1.96070413
60Long eyelashes (HP:0000527)1.95955049
61Fibroma (HP:0010614)1.94332314
62Sacral dimple (HP:0000960)1.94206127
63Ulnar bowing (HP:0003031)1.93281011
64Sparse lateral eyebrow (HP:0005338)1.91915193
65Progressive external ophthalmoplegia (HP:0000590)1.91703351
66High pitched voice (HP:0001620)1.91364208
67Megalocornea (HP:0000485)1.90355883
68Abnormality of the distal phalanges of the toes (HP:0010182)1.90298117
69Flattened epiphyses (HP:0003071)1.89297634
70Acute lymphatic leukemia (HP:0006721)1.88634007
71Abnormality of the intervertebral disk (HP:0005108)1.87830662
72Enlarged penis (HP:0000040)1.87820994
73Radial bowing (HP:0002986)1.86637014
74Bladder diverticulum (HP:0000015)1.86290540
75Broad palm (HP:0001169)1.85030193
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84806319
77Broad thumb (HP:0011304)1.83574576
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.83397306
79Spastic diplegia (HP:0001264)1.83205330
80Spina bifida occulta (HP:0003298)1.82945124
81Abnormality of chromosome segregation (HP:0002916)1.81975454
82Deep palmar crease (HP:0006191)1.81491728
83Insidious onset (HP:0003587)1.81355115
84Termporal pattern (HP:0011008)1.81355115
85Mitral valve prolapse (HP:0001634)1.79456593
86Abnormality of the radial head (HP:0003995)1.78656568
87Abnormality of the diencephalon (HP:0010662)1.78481098
88Generalized hypotonia (HP:0001290)1.77821258
89Hepatoblastoma (HP:0002884)1.77647282
90Dislocated radial head (HP:0003083)1.76942091
91Glioma (HP:0009733)1.76766685
92Anal stenosis (HP:0002025)1.75779107
93Somatic mutation (HP:0001428)1.75109447
94Disproportionate tall stature (HP:0001519)1.74422024
95Micronodular cirrhosis (HP:0001413)1.74273263
96Flat acetabular roof (HP:0003180)1.73708269
97Progressive hearing impairment (HP:0001730)1.73661566
98Genu recurvatum (HP:0002816)1.73483596
99Bowing of the arm (HP:0006488)1.72886199
100Bowed forearm bones (HP:0003956)1.72886199
101Radioulnar synostosis (HP:0002974)1.72809595
102Unilateral renal agenesis (HP:0000122)1.72730669
103Ankle contracture (HP:0006466)1.72715194
104Apathy (HP:0000741)1.72706351
105Patellar dislocation (HP:0002999)1.72035178
106Hand muscle atrophy (HP:0009130)1.71487837
107Urethral obstruction (HP:0000796)1.71377220
108Facial hemangioma (HP:0000329)1.70249973
109Broad phalanges of the hand (HP:0009768)1.69031648
110Broad distal phalanx of finger (HP:0009836)1.68914229
111Abnormality of the metopic suture (HP:0005556)1.68731316
112Diminished motivation (HP:0000745)1.68464055
113Hypercortisolism (HP:0001578)1.68429086
11411 pairs of ribs (HP:0000878)1.67397562
115Transitional cell carcinoma of the bladder (HP:0006740)1.66466126
116Skull defect (HP:0001362)1.66373686
117Selective tooth agenesis (HP:0001592)1.66015963
118Vertebral arch anomaly (HP:0008438)1.65833227
119Distal upper limb amyotrophy (HP:0007149)1.65008394
120Upper limb amyotrophy (HP:0009129)1.65008394
121Cerebral inclusion bodies (HP:0100314)1.64405567
122Tented upper lip vermilion (HP:0010804)1.63790452
123Cutis marmorata (HP:0000965)1.63612030
124Broad face (HP:0000283)1.63470459
125Skin tags (HP:0010609)1.63051329
126Abnormal number of incisors (HP:0011064)1.63018057
127Short 5th finger (HP:0009237)1.62734195
128Malignant gastrointestinal tract tumors (HP:0006749)1.62203764
129Gastrointestinal carcinoma (HP:0002672)1.62203764
130Vertebral compression fractures (HP:0002953)1.61584112
131Thin bony cortex (HP:0002753)1.61562436
132Supernumerary ribs (HP:0005815)1.61304730
133Dilatation of the ascending aorta (HP:0005111)1.61101903
134Pseudobulbar signs (HP:0002200)1.60873950
135Abnormal ossification of hand bones (HP:0005921)1.60760064
136Bladder carcinoma (HP:0002862)1.60275573
137Bladder neoplasm (HP:0009725)1.60275573
138Capillary hemangiomas (HP:0005306)1.59883345
139Angiofibromas (HP:0010615)1.59268737
140Adenoma sebaceum (HP:0009720)1.59268737
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59147435
142Protrusio acetabuli (HP:0003179)1.58700596
143Nasal polyposis (HP:0100582)1.57733043
144Broad alveolar ridges (HP:0000187)1.56998153
145Leiomyosarcoma (HP:0100243)1.55932032
146Uterine leiomyosarcoma (HP:0002891)1.55932032
147Personality changes (HP:0000751)1.55722668
148Turricephaly (HP:0000262)1.55665172
149Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.55296386
150Neoplasm of striated muscle (HP:0009728)1.55260238
151Intellectual disability, profound (HP:0002187)1.55236838
152Abnormality of the thoracic spine (HP:0100711)1.55120789
153Proximal placement of thumb (HP:0009623)1.54847434
154Missing ribs (HP:0000921)1.54725635
155Broad finger (HP:0001500)1.54433580
156Deviation of the thumb (HP:0009603)1.54179449
157Neoplasm of the adrenal cortex (HP:0100641)1.54129983
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.52635485
159Germ cell neoplasia (HP:0100728)1.51590562
160Progressive sensorineural hearing impairment (HP:0000408)1.50939340
161Wide cranial sutures (HP:0010537)1.50721996
162Neuronal loss in central nervous system (HP:0002529)1.48827634
163Growth hormone excess (HP:0000845)1.47216022
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.46482842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.34710653
2EEF2K4.20963717
3MAP3K104.12690850
4SMG14.01272415
5PKN22.89329079
6PRPF4B2.72883538
7CDK122.69458415
8ICK2.66402653
9RIPK12.32200050
10SIK22.20144501
11CDC72.16138763
12LMTK21.99954540
13PTK61.80807349
14IRAK31.79550362
15PDGFRA1.77284670
16ALK1.75953948
17VRK21.73639756
18TYRO31.66242335
19NEK21.66207526
20TSSK61.57297700
21FGFR41.54723365
22SCYL21.54628510
23LRRK21.46194557
24SIK31.43116125
25DDR21.38482975
26TTK1.37533124
27MAP3K91.34047915
28PRKD31.33058564
29CDK61.30825626
30MAP4K11.29613612
31MARK11.29607816
32BMX1.28069039
33TAOK11.25571889
34TAF11.22728600
35CDK41.18651799
36BUB11.15916226
37BRD41.15712280
38MTOR1.15086380
39TTN1.13609236
40MAP3K141.10332223
41DAPK11.10275950
42DYRK1B1.07338465
43PAK41.07333368
44ERN11.05015616
45HIPK21.03482722
46PASK1.02759884
47DYRK31.00407370
48CAMKK10.97356790
49STK100.96662642
50MAP3K40.96528285
51KSR10.95932257
52TGFBR10.95008955
53RET0.94807335
54CAMK1G0.92686213
55PRKD20.91075616
56UHMK10.90905236
57MAPK110.85876799
58ATR0.84194071
59NTRK20.83179978
60RPS6KB20.82844384
61KSR20.82599119
62MAP3K60.80345410
63ILK0.79521142
64LATS20.75456333
65SIK10.75178040
66MAP2K20.74519397
67PAK60.72795499
68CLK10.72045972
69GRK60.71812620
70CHEK10.71309204
71PAK20.71202195
72RPS6KA40.68969927
73PLK40.68817436
74MARK20.68167072
75MAP3K80.67518693
76PDGFRB0.67513527
77CDK20.65542757
78CSF1R0.64950476
79RPS6KA20.63526628
80CDK90.63032536
81CDK70.62661233
82WEE10.62316131
83EPHB10.61327168
84MAP2K70.61087836
85MAP3K70.59164815
86DAPK20.58599128
87AURKA0.57331053
88NEK10.57123790
89EPHA20.57092311
90FGFR10.56830065
91PRKCH0.55281758
92CDK150.54844220
93CDC42BPA0.54764206
94TAOK20.53648223
95TESK10.52957572
96CDK11A0.52433520
97CAMK1D0.51154429
98RPS6KA10.51090249
99KIT0.50926776
100FGFR30.50359495
101NME20.49191466
102CDK180.48203630
103CDK80.48156069
104MKNK10.48001959
105RAF10.47642110
106HCK0.47619135
107BRAF0.47537116
108JAK30.46880150
109PLK10.46756207
110MAP2K30.46442548
111AURKB0.46149068
112PTK20.44625824
113CDK140.44622581
114FGR0.44352515
115MELK0.43633753
116MAPK90.43236515
117BTK0.42898489
118TESK20.42717861
119SGK30.41959286
120STK40.41650883
121FES0.41422659
122MATK0.41411737
123RPS6KB10.41295708
124MINK10.41006833
125CHEK20.40697673
126RPS6KC10.39925333
127RPS6KL10.39925333
128IRAK20.38040478
129ATM0.37479651
130MAP3K110.37020073
131STK380.36970430
132EPHB20.36784107
133ERBB30.36551565
134CDK10.36294769
135PRKDC0.36022428
136NEK90.35992146
137SRPK10.35750501

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.04319981
2Non-homologous end-joining_Homo sapiens_hsa034501.79929290
3mRNA surveillance pathway_Homo sapiens_hsa030151.79794267
4Colorectal cancer_Homo sapiens_hsa052101.75438274
5mTOR signaling pathway_Homo sapiens_hsa041501.67837249
6Endometrial cancer_Homo sapiens_hsa052131.62584109
7Neurotrophin signaling pathway_Homo sapiens_hsa047221.55948044
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53044756
9DNA replication_Homo sapiens_hsa030301.50406870
10Non-small cell lung cancer_Homo sapiens_hsa052231.49474709
11Spliceosome_Homo sapiens_hsa030401.46185659
12Glioma_Homo sapiens_hsa052141.45056343
13VEGF signaling pathway_Homo sapiens_hsa043701.42648879
14Notch signaling pathway_Homo sapiens_hsa043301.42204476
15B cell receptor signaling pathway_Homo sapiens_hsa046621.39238216
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36071172
17Base excision repair_Homo sapiens_hsa034101.34347243
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28574474
19Pancreatic cancer_Homo sapiens_hsa052121.28306741
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27661759
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25272005
22Acute myeloid leukemia_Homo sapiens_hsa052211.25103428
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24064159
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23796871
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22817750
26MicroRNAs in cancer_Homo sapiens_hsa052061.21965477
27RNA transport_Homo sapiens_hsa030131.19960219
28Hepatitis C_Homo sapiens_hsa051601.19253524
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18728544
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15231162
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.14326455
32Estrogen signaling pathway_Homo sapiens_hsa049151.12839971
33Basal cell carcinoma_Homo sapiens_hsa052171.12828282
34Cell cycle_Homo sapiens_hsa041101.11861056
35HTLV-I infection_Homo sapiens_hsa051661.11390509
36Oocyte meiosis_Homo sapiens_hsa041141.10654108
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08903807
38Dorso-ventral axis formation_Homo sapiens_hsa043201.08874328
39Viral myocarditis_Homo sapiens_hsa054161.08839094
40Bladder cancer_Homo sapiens_hsa052191.08721398
41Proteoglycans in cancer_Homo sapiens_hsa052051.07918470
42Other glycan degradation_Homo sapiens_hsa005111.06786562
43Mismatch repair_Homo sapiens_hsa034301.06480002
44Small cell lung cancer_Homo sapiens_hsa052221.04523938
45Hippo signaling pathway_Homo sapiens_hsa043901.02594337
46Hepatitis B_Homo sapiens_hsa051611.01138214
47ErbB signaling pathway_Homo sapiens_hsa040121.00804241
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00612602
49Viral carcinogenesis_Homo sapiens_hsa052030.99890898
50T cell receptor signaling pathway_Homo sapiens_hsa046600.99681435
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97773211
52Prolactin signaling pathway_Homo sapiens_hsa049170.97051960
53Long-term potentiation_Homo sapiens_hsa047200.96906090
54Type II diabetes mellitus_Homo sapiens_hsa049300.96341139
55Antigen processing and presentation_Homo sapiens_hsa046120.95179575
56Thyroid cancer_Homo sapiens_hsa052160.95014632
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.94760318
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94661751
59Hedgehog signaling pathway_Homo sapiens_hsa043400.94052705
60Influenza A_Homo sapiens_hsa051640.91626368
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91437411
62Vibrio cholerae infection_Homo sapiens_hsa051100.91156001
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90781408
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89609285
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89196226
66Wnt signaling pathway_Homo sapiens_hsa043100.88226700
67Adherens junction_Homo sapiens_hsa045200.88062652
68Shigellosis_Homo sapiens_hsa051310.87540355
69Renal cell carcinoma_Homo sapiens_hsa052110.86982388
70Insulin signaling pathway_Homo sapiens_hsa049100.86895520
71Gap junction_Homo sapiens_hsa045400.86619056
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85949305
73Lysine degradation_Homo sapiens_hsa003100.85380970
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82796792
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82328782
76Osteoclast differentiation_Homo sapiens_hsa043800.82038899
77Prion diseases_Homo sapiens_hsa050200.81498177
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80440609
79TNF signaling pathway_Homo sapiens_hsa046680.80237086
80Focal adhesion_Homo sapiens_hsa045100.79986870
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79221618
82GnRH signaling pathway_Homo sapiens_hsa049120.78856324
83Primary immunodeficiency_Homo sapiens_hsa053400.78261177
84Herpes simplex infection_Homo sapiens_hsa051680.77099726
85FoxO signaling pathway_Homo sapiens_hsa040680.76007752
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75866999
87Platelet activation_Homo sapiens_hsa046110.75819857
88Nucleotide excision repair_Homo sapiens_hsa034200.75730025
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75408131
90Apoptosis_Homo sapiens_hsa042100.75162510
91MAPK signaling pathway_Homo sapiens_hsa040100.74101533
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73391218
93Toxoplasmosis_Homo sapiens_hsa051450.72248075
94Dopaminergic synapse_Homo sapiens_hsa047280.71779953
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71255592
96Endocytosis_Homo sapiens_hsa041440.71137851
97Biosynthesis of amino acids_Homo sapiens_hsa012300.70841135
98Insulin resistance_Homo sapiens_hsa049310.70824395
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70692604
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70287224
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.68676010
102Choline metabolism in cancer_Homo sapiens_hsa052310.68183320
103Pathways in cancer_Homo sapiens_hsa052000.66832329
104Measles_Homo sapiens_hsa051620.66708665
105Salmonella infection_Homo sapiens_hsa051320.66124342
106Leishmaniasis_Homo sapiens_hsa051400.66100047
107Oxytocin signaling pathway_Homo sapiens_hsa049210.65808732
108Melanoma_Homo sapiens_hsa052180.65338593
109Cholinergic synapse_Homo sapiens_hsa047250.65042499
110Prostate cancer_Homo sapiens_hsa052150.64923696
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64808431
112Alcoholism_Homo sapiens_hsa050340.64038331
113Chemokine signaling pathway_Homo sapiens_hsa040620.63908937
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.63321002
115HIF-1 signaling pathway_Homo sapiens_hsa040660.63193902
116Epstein-Barr virus infection_Homo sapiens_hsa051690.62955350
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62829083
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.62751472
119Olfactory transduction_Homo sapiens_hsa047400.62672770
120p53 signaling pathway_Homo sapiens_hsa041150.62614917
121Melanogenesis_Homo sapiens_hsa049160.61370995
122AMPK signaling pathway_Homo sapiens_hsa041520.61301311
123Glucagon signaling pathway_Homo sapiens_hsa049220.61232525
124Axon guidance_Homo sapiens_hsa043600.61067124
125N-Glycan biosynthesis_Homo sapiens_hsa005100.60829377
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60601131
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58401074
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.57905119
129Steroid biosynthesis_Homo sapiens_hsa001000.54289250
130Fanconi anemia pathway_Homo sapiens_hsa034600.53265149
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52137101
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50630628

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