NCOA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.72282904
2cytoplasmic mRNA processing body assembly (GO:0033962)4.44950248
3cell migration in hindbrain (GO:0021535)3.93741540
4pre-miRNA processing (GO:0031054)3.59079015
5regulation of clathrin-mediated endocytosis (GO:2000369)3.55422950
6histone H3-K4 trimethylation (GO:0080182)3.51745470
7NLS-bearing protein import into nucleus (GO:0006607)3.42468128
8regulation of RNA export from nucleus (GO:0046831)3.40879858
9histone H3-K4 methylation (GO:0051568)3.34823463
10positive regulation of CREB transcription factor activity (GO:0032793)3.20364926
11establishment of nucleus localization (GO:0040023)3.20197593
12regulation of glycogen (starch) synthase activity (GO:2000465)3.05059638
13regulation of nucleobase-containing compound transport (GO:0032239)3.03988880
14embryonic retina morphogenesis in camera-type eye (GO:0060059)3.01328450
15retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94517376
16neuron recognition (GO:0008038)2.87955130
17regulation of NFAT protein import into nucleus (GO:0051532)2.87584578
18interkinetic nuclear migration (GO:0022027)2.85542905
19nucleus localization (GO:0051647)2.85390888
20stress granule assembly (GO:0034063)2.83890935
21histone lysine methylation (GO:0034968)2.83493046
22regulation of ARF protein signal transduction (GO:0032012)2.83051235
23olfactory bulb development (GO:0021772)2.82620315
24monoubiquitinated protein deubiquitination (GO:0035520)2.82492372
25positive regulation of histone deacetylation (GO:0031065)2.79502109
26protein targeting to Golgi (GO:0000042)2.78180609
27regulation of axon extension involved in axon guidance (GO:0048841)2.77072521
28positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76019284
29regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76019284
30axonal fasciculation (GO:0007413)2.75475370
31insulin-like growth factor receptor signaling pathway (GO:0048009)2.73829475
32central nervous system projection neuron axonogenesis (GO:0021952)2.73797370
33nuclear pore complex assembly (GO:0051292)2.73343301
34establishment of protein localization to Golgi (GO:0072600)2.73174530
35cerebral cortex radially oriented cell migration (GO:0021799)2.72770006
36hippo signaling (GO:0035329)2.72034045
37N-terminal protein amino acid acetylation (GO:0006474)2.70710157
38peptidyl-threonine phosphorylation (GO:0018107)2.68031318
39cell-cell junction maintenance (GO:0045217)2.66881211
40peptidyl-lysine trimethylation (GO:0018023)2.65026167
41regulation of axon guidance (GO:1902667)2.63385355
42postsynaptic membrane organization (GO:0001941)2.61475231
43regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.60457994
44positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.59311248
45regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.59311248
46layer formation in cerebral cortex (GO:0021819)2.59178486
47synapse assembly (GO:0007416)2.59121184
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59093033
49regulation of sister chromatid cohesion (GO:0007063)2.58974899
50histone H3-K9 demethylation (GO:0033169)2.58838645
51positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.55331548
52growth hormone receptor signaling pathway (GO:0060396)2.55113678
53negative regulation of sodium ion transport (GO:0010766)2.51830310
54* glucocorticoid receptor signaling pathway (GO:0042921)2.49936057
55cell junction maintenance (GO:0034331)2.49852865
56peptidyl-threonine modification (GO:0018210)2.49646238
57negative regulation of cAMP-mediated signaling (GO:0043951)2.48364854
58locomotory exploration behavior (GO:0035641)2.47989676
59vesicle transport along microtubule (GO:0047496)2.47770290
60* corticosteroid receptor signaling pathway (GO:0031958)2.44759623
61phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44692890
62peptidyl-lysine dimethylation (GO:0018027)2.43228645
63regulation of acrosome reaction (GO:0060046)2.41984128
64auditory behavior (GO:0031223)2.40969566
65axon extension (GO:0048675)2.40773010
66central nervous system neuron axonogenesis (GO:0021955)2.40061212
67sodium ion export (GO:0071436)2.39580761
68positive regulation of gene expression, epigenetic (GO:0045815)2.39256232
69presynaptic membrane assembly (GO:0097105)2.39177919
70histone H4-K16 acetylation (GO:0043984)2.37919560
71negative regulation of histone methylation (GO:0031061)2.37453848
72heart morphogenesis (GO:0003007)2.37385090
73protein demethylation (GO:0006482)2.37190928
74protein dealkylation (GO:0008214)2.37190928
75histone H3-K9 modification (GO:0061647)2.35248808
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.33885059
77positive regulation by host of viral transcription (GO:0043923)2.32886666
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.32119033
79gastrulation with mouth forming second (GO:0001702)2.31322687
80regulation of fatty acid beta-oxidation (GO:0031998)2.31124502
81DNA alkylation (GO:0006305)2.28747121
82DNA methylation (GO:0006306)2.28747121
83neuron projection extension (GO:1990138)2.28719676
84auditory receptor cell differentiation (GO:0042491)2.28029288
85synaptic vesicle maturation (GO:0016188)2.27577759
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.25592305
87limb bud formation (GO:0060174)2.25436538
88negative regulation of cell killing (GO:0031342)2.24759560
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24759560
90histone methylation (GO:0016571)2.24640871
91histone H3-K36 demethylation (GO:0070544)2.24163071
92Golgi to endosome transport (GO:0006895)2.24052314
93semaphorin-plexin signaling pathway (GO:0071526)2.22223246
94cerebellar Purkinje cell differentiation (GO:0021702)2.21026530
95dendrite development (GO:0016358)2.20437356
96adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.20319779
97sister chromatid cohesion (GO:0007062)2.19988288
98cellular response to growth hormone stimulus (GO:0071378)2.19672470
99gene silencing by RNA (GO:0031047)2.18620058
100protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.18133593
101morphogenesis of an epithelial sheet (GO:0002011)2.17750544
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.17182353
103cerebral cortex development (GO:0021987)2.16968279
104histone lysine demethylation (GO:0070076)2.16446896
105positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.16049211
106positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.16049211
107positive regulation of mitotic sister chromatid separation (GO:1901970)2.16049211
108establishment of spindle localization (GO:0051293)2.15095765
109cerebral cortex cell migration (GO:0021795)2.13866385
110neurotransmitter-gated ion channel clustering (GO:0072578)2.13805790
111transmission of nerve impulse (GO:0019226)2.13294084
112spinal cord development (GO:0021510)2.13270185
113regulation of transforming growth factor beta2 production (GO:0032909)2.13256199
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.12880848
115regulation of translation, ncRNA-mediated (GO:0045974)2.12880848
116negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.12880848
117developmental cell growth (GO:0048588)2.12639309
118coronary vasculature morphogenesis (GO:0060977)2.12535892
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.12306607
120RNA stabilization (GO:0043489)2.12260882
121mRNA stabilization (GO:0048255)2.12260882
122regulation of female gonad development (GO:2000194)2.12041117
123mechanosensory behavior (GO:0007638)2.11990538
124ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.11964030
125vocalization behavior (GO:0071625)2.11844268
126negative regulation of circadian rhythm (GO:0042754)2.11577521
127regulation of protein deacetylation (GO:0090311)2.11082657
128positive regulation of mRNA catabolic process (GO:0061014)2.11028568
129pyrimidine nucleobase catabolic process (GO:0006208)2.10858754
130suckling behavior (GO:0001967)2.10643009
131dendrite morphogenesis (GO:0048813)2.09776823
132regulation of histone deacetylation (GO:0031063)2.09764281
133nuclear pore organization (GO:0006999)2.09728891
134peptidyl-lysine methylation (GO:0018022)2.09130126
135cerebellar granule cell differentiation (GO:0021707)2.08815320
136negative regulation of dendrite development (GO:2000171)2.08771477
137regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.08572006
138presynaptic membrane organization (GO:0097090)2.08041487
139dendritic spine morphogenesis (GO:0060997)2.07058166
140regulation of short-term neuronal synaptic plasticity (GO:0048172)2.05990732
141regulation of DNA endoreduplication (GO:0032875)2.05110388
142embryonic body morphogenesis (GO:0010172)2.03974004
143G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.02958460
144negative regulation of vascular permeability (GO:0043116)2.01346726
145histone acetylation (GO:0016573)2.01056255
146embryonic viscerocranium morphogenesis (GO:0048703)2.00704597
147histone H2A monoubiquitination (GO:0035518)1.99065052
148body morphogenesis (GO:0010171)1.98870736
149internal peptidyl-lysine acetylation (GO:0018393)1.98842920
150histone demethylation (GO:0016577)1.98820432
151regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.97796763
152negative regulation of fatty acid transport (GO:2000192)1.97537803
153gene silencing (GO:0016458)1.96895363
154positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.96828067
155mitotic chromosome condensation (GO:0007076)1.96382149
156nerve growth factor signaling pathway (GO:0038180)1.95459865
157cardiac myofibril assembly (GO:0055003)1.95038781
158negative regulation of histone modification (GO:0031057)1.94634475
159histone H3-K9 methylation (GO:0051567)1.94225200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87812470
2EZH2_22144423_ChIP-Seq_EOC_Human2.58274139
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.58147247
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38595205
5TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.21003083
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12319228
7DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.11354105
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.06314919
9SALL1_21062744_ChIP-ChIP_HESCs_Human1.99424372
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98596345
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94675645
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.88451145
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83174226
14REST_21632747_ChIP-Seq_MESCs_Mouse1.82125995
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81882924
16TCF7_22412390_ChIP-Seq_EML_Mouse1.80126442
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79572637
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78990600
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.75589023
20KDM2B_26808549_Chip-Seq_DND41_Human1.74310902
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.74055106
22* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70372469
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69537889
24DROSHA_22980978_ChIP-Seq_HELA_Human1.69101860
25MYC_22102868_ChIP-Seq_BL_Human1.65873472
26FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.65438041
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64944841
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63717792
29TP53_16413492_ChIP-PET_HCT116_Human1.61138214
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60978872
31KDM2B_26808549_Chip-Seq_K562_Human1.60915994
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58975040
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.58291868
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53905434
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52830796
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.52711450
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.52690384
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52571363
39WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50379360
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46714783
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.45462971
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43091592
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.42303241
44AHR_22903824_ChIP-Seq_MCF-7_Human1.41608796
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41414591
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40291678
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39341246
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38656307
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37817322
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37757390
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37577344
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.36913950
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36554409
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.36369056
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35328437
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34439172
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.32230000
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32183625
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31816323
60AR_19668381_ChIP-Seq_PC3_Human1.31756268
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30617181
62RNF2_27304074_Chip-Seq_NSC_Mouse1.26656358
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26187357
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24301114
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23372891
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22759872
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22665901
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21684914
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21398870
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21335343
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20429855
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20187737
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.19588744
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18958252
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17785140
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17082806
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.17001620
78* STAT3_23295773_ChIP-Seq_U87_Human1.16996431
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16820702
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.15327267
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.15035210
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14638556
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14319454
84AR_25329375_ChIP-Seq_VCAP_Human1.14272478
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13550277
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13550277
87SMAD4_21799915_ChIP-Seq_A2780_Human1.13444795
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13258548
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12628544
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10242554
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.10158791
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09167218
93RXR_22108803_ChIP-Seq_LS180_Human1.08687091
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07862353
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07771108
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.07517870
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07285840
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.05364542
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05196267
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05119270
101* BRD4_25478319_ChIP-Seq_HGPS_Human1.03625748
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03619656
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03619656
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02238470
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01985642
106SPI1_23127762_ChIP-Seq_K562_Human1.01900101
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.01647421
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00327087
109TCF4_23295773_ChIP-Seq_U87_Human1.00258316
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00234209
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00125520
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99896944
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98998749
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.98455337
115RING1B_27294783_Chip-Seq_ESCs_Mouse0.98427562
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98085524
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97979727
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96682367
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.95219403
120ER_23166858_ChIP-Seq_MCF-7_Human0.94566878
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94565629
122GBX2_23144817_ChIP-Seq_PC3_Human0.94483512
123AR_21572438_ChIP-Seq_LNCaP_Human0.94279737
124VDR_24787735_ChIP-Seq_THP-1_Human0.93443553
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92866109
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.92574874
127KDM2B_26808549_Chip-Seq_REH_Human0.92028440
128ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91828632
129* RUNX2_22187159_ChIP-Seq_PCA_Human0.91770391
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91527457
131JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89942825
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.88169930
133ZNF274_21170338_ChIP-Seq_K562_Hela0.87351402
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.86869105
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.85753419
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85669655
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82993512
138RUNX_20019798_ChIP-Seq_JUKART_Human0.82874337
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82827244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.27088340
2MP0005076_abnormal_cell_differentiation3.38502550
3MP0005409_darkened_coat_color3.24914314
4MP0004859_abnormal_synaptic_plasticity2.78491240
5MP0003787_abnormal_imprinting2.75007445
6MP0003705_abnormal_hypodermis_morpholog2.47009838
7MP0005423_abnormal_somatic_nervous2.21089862
8MP0002909_abnormal_adrenal_gland2.19905074
9MP0003121_genomic_imprinting2.13925839
10MP0005187_abnormal_penis_morphology2.03999453
11MP0010352_gastrointestinal_tract_polyps2.00852351
12MP0008961_abnormal_basal_metabolism1.97862768
13MP0009780_abnormal_chondrocyte_physiolo1.90764986
14MP0003300_gastrointestinal_ulcer1.89366236
15MP0005248_abnormal_Harderian_gland1.82422625
16MP0000566_synostosis1.79583729
17MP0002822_catalepsy1.76001423
18MP0000733_abnormal_muscle_development1.72767809
19MP0000631_abnormal_neuroendocrine_gland1.64450808
20MP0002184_abnormal_innervation1.62447534
21MP0010368_abnormal_lymphatic_system1.61913229
22MP0002064_seizures1.60549879
23MP0002572_abnormal_emotion/affect_behav1.58426560
24MP0005386_behavior/neurological_phenoty1.55063833
25MP0004924_abnormal_behavior1.55063833
26MP0000537_abnormal_urethra_morphology1.54586170
27MP0004185_abnormal_adipocyte_glucose1.53629685
28MP0000955_abnormal_spinal_cord1.53429185
29MP0008877_abnormal_DNA_methylation1.52431436
30MP0001486_abnormal_startle_reflex1.52356577
31MP0010307_abnormal_tumor_latency1.50778563
32MP0002557_abnormal_social/conspecific_i1.50626679
33MP0003890_abnormal_embryonic-extraembry1.49498092
34* MP0003935_abnormal_craniofacial_develop1.49164700
35MP0003122_maternal_imprinting1.47081407
36MP0002734_abnormal_mechanical_nocicepti1.46733352
37MP0003091_abnormal_cell_migration1.46597510
38MP0001299_abnormal_eye_distance/1.45666996
39MP0001849_ear_inflammation1.45089941
40MP0009046_muscle_twitch1.45039901
41MP0004808_abnormal_hematopoietic_stem1.44924614
42MP0009278_abnormal_bone_marrow1.43952262
43MP0005670_abnormal_white_adipose1.43498561
44MP0002249_abnormal_larynx_morphology1.42913408
45MP0004381_abnormal_hair_follicle1.42788985
46MP0003303_peritoneal_inflammation1.42610201
47MP0003123_paternal_imprinting1.41969049
48MP0004233_abnormal_muscle_weight1.41847082
49MP0008057_abnormal_DNA_replication1.40729151
50MP0000534_abnormal_ureter_morphology1.40085642
51MP0001502_abnormal_circadian_rhythm1.39908841
52MP0002877_abnormal_melanocyte_morpholog1.39809724
53MP0009745_abnormal_behavioral_response1.38684685
54MP0002084_abnormal_developmental_patter1.37358505
55MP0005646_abnormal_pituitary_gland1.36135553
56MP0000428_abnormal_craniofacial_morphol1.35032313
57MP0003115_abnormal_respiratory_system1.34339079
58* MP0002925_abnormal_cardiovascular_devel1.31876534
59MP0002272_abnormal_nervous_system1.29497671
60* MP0003984_embryonic_growth_retardation1.29001967
61MP0002653_abnormal_ependyma_morphology1.28477614
62* MP0002882_abnormal_neuron_morphology1.27736204
63* MP0002088_abnormal_embryonic_growth/wei1.27190194
64MP0001944_abnormal_pancreas_morphology1.27160757
65MP0004270_analgesia1.26105181
66MP0002876_abnormal_thyroid_physiology1.26104142
67MP0000778_abnormal_nervous_system1.25369759
68MP0003385_abnormal_body_wall1.24468540
69MP0004197_abnormal_fetal_growth/weight/1.23467933
70MP0002735_abnormal_chemical_nociception1.23433995
71MP0003635_abnormal_synaptic_transmissio1.23336981
72MP0004510_myositis1.21909139
73MP0004142_abnormal_muscle_tone1.20791836
74MP0002067_abnormal_sensory_capabilities1.20652829
75MP0010030_abnormal_orbit_morphology1.19478738
76MP0002085_abnormal_embryonic_tissue1.18952208
77MP0001970_abnormal_pain_threshold1.17126838
78MP0003880_abnormal_central_pattern1.17012193
79* MP0009703_decreased_birth_body1.16908034
80* MP0002086_abnormal_extraembryonic_tissu1.16385853
81MP0003879_abnormal_hair_cell1.15613913
82MP0003045_fibrosis1.15361476
83MP0003172_abnormal_lysosome_physiology1.15313862
84MP0002733_abnormal_thermal_nociception1.15081252
85* MP0001672_abnormal_embryogenesis/_devel1.14383173
86* MP0005380_embryogenesis_phenotype1.14383173
87MP0004885_abnormal_endolymph1.14332770
88MP0003950_abnormal_plasma_membrane1.12235572
89MP0003937_abnormal_limbs/digits/tail_de1.11835045
90* MP0003861_abnormal_nervous_system1.11263079
91MP0000015_abnormal_ear_pigmentation1.09157242
92MP0004043_abnormal_pH_regulation1.07525706
93MP0005645_abnormal_hypothalamus_physiol1.06588029
94MP0001984_abnormal_olfaction1.06469971
95MP0002116_abnormal_craniofacial_bone1.05171468
96MP0001730_embryonic_growth_arrest1.04566751
97* MP0010630_abnormal_cardiac_muscle1.04237939
98* MP0003755_abnormal_palate_morphology1.03700581
99MP0002063_abnormal_learning/memory/cond1.02627851
100MP0000003_abnormal_adipose_tissue1.01071631
101MP0005174_abnormal_tail_pigmentation1.01068310
102MP0002009_preneoplasia1.00881088
103MP0005623_abnormal_meninges_morphology1.00576157
104MP0002098_abnormal_vibrissa_morphology1.00553928
105* MP0000350_abnormal_cell_proliferation0.99878298
106* MP0001697_abnormal_embryo_size0.98022466
107* MP0000266_abnormal_heart_morphology0.97507595
108MP0005367_renal/urinary_system_phenotyp0.97443887
109MP0000516_abnormal_urinary_system0.97443887
110MP0001501_abnormal_sleep_pattern0.95820122
111MP0005448_abnormal_energy_balance0.95247227
112MP0009115_abnormal_fat_cell0.95202790
113MP0000432_abnormal_head_morphology0.94040297
114MP0005379_endocrine/exocrine_gland_phen0.94021155
115MP0004134_abnormal_chest_morphology0.93229337
116MP0000427_abnormal_hair_cycle0.92754722
117MP0003632_abnormal_nervous_system0.90747391
118MP0003183_abnormal_peptide_metabolism0.90262818
119MP0003566_abnormal_cell_adhesion0.89467687
120MP0006292_abnormal_olfactory_placode0.89163880
121MP0009053_abnormal_anal_canal0.89096330
122MP0009250_abnormal_appendicular_skeleto0.88387838
123MP0005499_abnormal_olfactory_system0.88015668
124MP0005394_taste/olfaction_phenotype0.88015668
125MP0001348_abnormal_lacrimal_gland0.87132862
126MP0001270_distended_abdomen0.86787855
127MP0005551_abnormal_eye_electrophysiolog0.86457135
128MP0004087_abnormal_muscle_fiber0.86368630
129* MP0002152_abnormal_brain_morphology0.85791753
130MP0004130_abnormal_muscle_cell0.85403598
131MP0004145_abnormal_muscle_electrophysio0.85118560
132MP0004858_abnormal_nervous_system0.84806210
133MP0008569_lethality_at_weaning0.84075077
134* MP0009672_abnormal_birth_weight0.83878584
135MP0006072_abnormal_retinal_apoptosis0.83694192
136MP0010678_abnormal_skin_adnexa0.83389159
137MP0002752_abnormal_somatic_nervous0.82979986
138MP0002166_altered_tumor_susceptibility0.82581362
139MP0001943_abnormal_respiration0.82004421
140MP0002066_abnormal_motor_capabilities/c0.81740802
141MP0000383_abnormal_hair_follicle0.79691407
142MP0001915_intracranial_hemorrhage0.78653959
143* MP0001784_abnormal_fluid_regulation0.78037852
144MP0005375_adipose_tissue_phenotype0.77720357
145MP0003942_abnormal_urinary_system0.77550679
146MP0002092_abnormal_eye_morphology0.76465162
147MP0005666_abnormal_adipose_tissue0.76438708
148MP0002396_abnormal_hematopoietic_system0.76390825
149MP0000767_abnormal_smooth_muscle0.75377445
150MP0004811_abnormal_neuron_physiology0.74395225
151MP0003828_pulmonary_edema0.73564880
152MP0002928_abnormal_bile_duct0.73341781
153MP0005397_hematopoietic_system_phenotyp0.73114252
154MP0001545_abnormal_hematopoietic_system0.73114252
155MP0001293_anophthalmia0.72643087
156MP0001346_abnormal_lacrimal_gland0.72590877
157MP0008770_decreased_survivor_rate0.72466957
158MP0003077_abnormal_cell_cycle0.72128083
159MP0010234_abnormal_vibrissa_follicle0.71142021
160MP0003119_abnormal_digestive_system0.70426418
161MP0002081_perinatal_lethality0.69524272

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.75074530
2Abnormality of the fingertips (HP:0001211)3.73481776
3Genetic anticipation (HP:0003743)3.53624952
4Short 4th metacarpal (HP:0010044)3.53316091
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53316091
6Hyperventilation (HP:0002883)3.47121378
7Macroorchidism (HP:0000053)3.43081162
8Long eyelashes (HP:0000527)3.08409245
9Obstructive sleep apnea (HP:0002870)3.07496050
10Narrow palate (HP:0000189)2.96847039
11Papillary thyroid carcinoma (HP:0002895)2.83089834
12Trigonocephaly (HP:0000243)2.78763420
13Shallow orbits (HP:0000586)2.74357107
14Urethral obstruction (HP:0000796)2.69335974
15Laryngomalacia (HP:0001601)2.59740204
16Abnormality of the 4th metacarpal (HP:0010012)2.58374098
17Obsessive-compulsive behavior (HP:0000722)2.49118311
18Abnormality of the aortic arch (HP:0012303)2.45895885
19Shawl scrotum (HP:0000049)2.30558647
20Abnormality of the phalanges of the hallux (HP:0010057)2.29183120
21Increased nuchal translucency (HP:0010880)2.27949500
22Truncal obesity (HP:0001956)2.26170898
23Hyperacusis (HP:0010780)2.25415598
24Heterotopia (HP:0002282)2.24322017
25Absent speech (HP:0001344)2.23577899
26Midline defect of the nose (HP:0004122)2.18322552
27EEG with generalized epileptiform discharges (HP:0011198)2.14730000
28Tapered finger (HP:0001182)2.14399208
29Hypsarrhythmia (HP:0002521)2.12789173
30Abnormality of the intervertebral disk (HP:0005108)2.12056391
31Broad thumb (HP:0011304)2.11851611
32Abnormality of chromosome segregation (HP:0002916)2.11692850
33Epileptiform EEG discharges (HP:0011182)2.11427484
34Tented upper lip vermilion (HP:0010804)2.11314849
35Aqueductal stenosis (HP:0002410)2.10183193
36Germ cell neoplasia (HP:0100728)2.09437991
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.09397292
38Hypoplastic nipples (HP:0002557)2.08020939
39Dysmetric saccades (HP:0000641)2.06931171
40Exotropia (HP:0000577)2.06865061
41Enlarged penis (HP:0000040)2.06677007
42Epileptic encephalopathy (HP:0200134)2.06112367
43Focal seizures (HP:0007359)2.04631213
44Elfin facies (HP:0004428)2.03182860
45Tibial bowing (HP:0002982)2.02575989
46Lip pit (HP:0100267)2.02370111
47Thick eyebrow (HP:0000574)1.98482575
48Broad-based gait (HP:0002136)1.98222863
49Renovascular hypertension (HP:0100817)1.96752420
50Abnormality of the nasal septum (HP:0000419)1.96546678
51Excessive salivation (HP:0003781)1.94401444
52Drooling (HP:0002307)1.94401444
53Sacral dimple (HP:0000960)1.92465410
54Absent frontal sinuses (HP:0002688)1.91758760
55Renal duplication (HP:0000075)1.90590024
56Abnormality of the pubic bones (HP:0003172)1.89178659
57Transitional cell carcinoma of the bladder (HP:0006740)1.87190612
58Deep palmar crease (HP:0006191)1.86167937
59Hypoplasia of the maxilla (HP:0000327)1.85903794
60Protruding tongue (HP:0010808)1.85815081
61Chorioretinal atrophy (HP:0000533)1.83443198
62Acute myeloid leukemia (HP:0004808)1.82441326
63Oligodontia (HP:0000677)1.81130183
64Hepatoblastoma (HP:0002884)1.80121069
65Blue irides (HP:0000635)1.79739590
66Neoplasm of the adrenal cortex (HP:0100641)1.79510063
67Short phalanx of the thumb (HP:0009660)1.78596886
68Prominent nose (HP:0000448)1.78325659
69Inappropriate behavior (HP:0000719)1.76075865
70Pointed chin (HP:0000307)1.76036274
71Febrile seizures (HP:0002373)1.75770857
72Gastroesophageal reflux (HP:0002020)1.75761246
73Progressive cerebellar ataxia (HP:0002073)1.75039862
74Low posterior hairline (HP:0002162)1.74844574
75Overriding aorta (HP:0002623)1.74761382
76Gaze-evoked nystagmus (HP:0000640)1.74323217
77Broad alveolar ridges (HP:0000187)1.73435176
78Deep philtrum (HP:0002002)1.73361440
79Short 1st metacarpal (HP:0010034)1.73065038
80Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73065038
81Hemiparesis (HP:0001269)1.72851677
82Abnormality of the astrocytes (HP:0100707)1.72683239
83Astrocytoma (HP:0009592)1.72683239
84Hypoplastic labia majora (HP:0000059)1.72525871
85Neoplasm of the heart (HP:0100544)1.72464708
86Broad face (HP:0000283)1.72145317
87Oligodactyly (HP:0012165)1.71738865
88Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71332180
89Abnormality of the ischium (HP:0003174)1.71123208
90Subacute progressive viral hepatitis (HP:0006572)1.69872007
91Lymphangioma (HP:0100764)1.68542090
92Impulsivity (HP:0100710)1.68256741
93Septate vagina (HP:0001153)1.67965317
94Facial hemangioma (HP:0000329)1.67932408
95Urinary bladder sphincter dysfunction (HP:0002839)1.67766853
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67405119
97Abnormality of the distal phalanx of the thumb (HP:0009617)1.67305662
98Synophrys (HP:0000664)1.67248386
99Bladder neoplasm (HP:0009725)1.66742242
100Bladder carcinoma (HP:0002862)1.66742242
101Hypoplastic ischia (HP:0003175)1.64963845
102Neoplasm of the oral cavity (HP:0100649)1.64506549
103Cubitus valgus (HP:0002967)1.63923131
104Focal motor seizures (HP:0011153)1.63844529
105Broad phalanges of the hand (HP:0009768)1.63027181
106Attention deficit hyperactivity disorder (HP:0007018)1.62613843
107Oligodactyly (hands) (HP:0001180)1.62313062
108Highly arched eyebrow (HP:0002553)1.62198274
109Disproportionate tall stature (HP:0001519)1.61760689
110Exostoses (HP:0100777)1.61393865
111Disinhibition (HP:0000734)1.61055478
112Deviation of the hallux (HP:0010051)1.60962893
113Hyperkalemia (HP:0002153)1.60851187
114Supernumerary ribs (HP:0005815)1.60655591
115Alacrima (HP:0000522)1.60500730
116Leiomyosarcoma (HP:0100243)1.60403094
117Uterine leiomyosarcoma (HP:0002891)1.60403094
118Megalencephaly (HP:0001355)1.60262595
119Cerebral aneurysm (HP:0004944)1.60149690
120Aortic aneurysm (HP:0004942)1.60013418
121Spinal cord lesions (HP:0100561)1.58377182
122Syringomyelia (HP:0003396)1.58377182
123Hallux valgus (HP:0001822)1.58221573
124Ankyloglossia (HP:0010296)1.57868126
125Lissencephaly (HP:0001339)1.57803034
126Low anterior hairline (HP:0000294)1.57351654
127Mitral valve prolapse (HP:0001634)1.57275623
128Overgrowth (HP:0001548)1.57146859
129Anteriorly placed anus (HP:0001545)1.57014163
130Deviation of the thumb (HP:0009603)1.56653086
131Broad finger (HP:0001500)1.55767545
132Anal stenosis (HP:0002025)1.55476570
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55328180
134Pachygyria (HP:0001302)1.55183338
135Smooth philtrum (HP:0000319)1.54466968
136Action tremor (HP:0002345)1.54448074
137Abnormality of the 1st metacarpal (HP:0010009)1.54403524
138Fair hair (HP:0002286)1.54374102
139Sporadic (HP:0003745)1.54354228
140Widely spaced teeth (HP:0000687)1.54287630
141Stereotypic behavior (HP:0000733)1.54091398
142Aneurysm (HP:0002617)1.53655181
143Open mouth (HP:0000194)1.53454753
144Dislocated radial head (HP:0003083)1.53432900
145Flat acetabular roof (HP:0003180)1.53161106
146Cutis marmorata (HP:0000965)1.53132685
147Sandal gap (HP:0001852)1.53070595
148Skin tags (HP:0010609)1.53043308
149Rectal prolapse (HP:0002035)1.52117942
150Depressed nasal tip (HP:0000437)1.52027356
151Spondylolisthesis (HP:0003302)1.51613534
152Impaired smooth pursuit (HP:0007772)1.51613176
153Abnormality of the labia majora (HP:0012881)1.51527957
154Dental malocclusion (HP:0000689)1.51432770
155Termporal pattern (HP:0011008)1.50919115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.04211591
2LATS14.03039197
3CAMK1G3.10552731
4CAMK1D2.63292593
5CASK2.46400502
6TRIB32.15315679
7MAP3K42.14316632
8DMPK2.12482071
9PRKD31.90982058
10LATS21.88900586
11CAMKK21.81915602
12BRD41.78515174
13TAOK11.72999287
14SIK21.68999188
15STK31.68190930
16AKT31.60766310
17MAP3K91.56962185
18TYRO31.54140496
19RIPK11.49911204
20MAPK131.37539184
21ICK1.36379438
22FGFR21.34572279
23TNIK1.31900400
24PDGFRB1.31797907
25NTRK31.30794054
26RET1.30092344
27SGK31.29843738
28MAP3K61.29064917
29PAK61.29023654
30PDGFRA1.28964277
31MTOR1.27018138
32EPHA31.24585159
33SIK31.22130562
34KSR11.21525646
35CDC71.18601057
36SIK11.16174370
37PKN21.15631899
38STK381.14359022
39MAP2K41.11681107
40CDK61.11018095
41MAP3K101.10744516
42PTK61.08264330
43FGFR41.04640128
44WNK41.03970210
45MARK11.03711487
46NTRK21.00743927
47MARK20.99726188
48EEF2K0.98458979
49PNCK0.97771464
50NEK20.97108320
51WNK10.95664963
52CDK90.93642588
53TAOK30.93357853
54SGK20.92820777
55KSR20.91850290
56PRKCH0.91196574
57ALK0.91043376
58NUAK10.89758771
59FGFR30.87328887
60CDC42BPA0.81848067
61YES10.81739753
62PINK10.79533223
63PTK20.77933410
64NLK0.77533642
65PRKCZ0.75729616
66ERN10.75257587
67CAMKK10.75153041
68PRKAA20.75112707
69PRPF4B0.74109886
70BCR0.73742433
71MAP3K70.72077142
72CDK40.71612708
73STK390.69194575
74CSNK1A1L0.68207593
75FGFR10.67016918
76MARK30.66503934
77MAPK100.66365539
78STK110.65719286
79UHMK10.65686812
80HIPK20.65673932
81CAMK40.63149804
82MAP2K70.62390225
83CHEK10.61468637
84BMX0.60681526
85DYRK1B0.60607423
86ERBB20.60180247
87MELK0.60129975
88MINK10.58981750
89EPHA40.57426541
90MAPK140.54381785
91GSK3B0.54275453
92DAPK20.54103867
93PTK2B0.53963188
94DDR20.53335990
95SGK10.53089219
96ATM0.52580965
97TTN0.51593123
98EPHB10.51544236
99FER0.51147472
100PLK20.51126310
101DYRK1A0.51092833
102MET0.51046034
103MAP3K20.51029880
104CHEK20.50662391
105PRKD20.50499621
106MAPK110.49577407
107CDK20.48908130
108PHKG10.48438988
109PHKG20.48438988
110PRKAA10.48167125
111ERBB30.47749825
112STK38L0.47748001
113IRAK10.46929167
114RPS6KA20.46894232
115CSNK1D0.46648535
116TRIM280.46010103
117RIPK40.44817396
118SGK2230.43695108
119SGK4940.43695108
120FRK0.43658165
121MAPK80.43223192
122TNK20.42313553
123JAK10.42213129
124INSRR0.41997712
125CDK10.41933486
126PAK30.41755223
127CHUK0.40710104
128CAMK10.40304487
129CDK50.40292812
130RPS6KA30.39054555
131LMTK20.35681797
132RPS6KB10.35384791
133MAP3K130.34944409
134CSNK1E0.33961159

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050331.87120374
2Dorso-ventral axis formation_Homo sapiens_hsa043201.60304252
3Thyroid hormone signaling pathway_Homo sapiens_hsa049191.52430395
4Type II diabetes mellitus_Homo sapiens_hsa049301.51973351
5Fatty acid biosynthesis_Homo sapiens_hsa000611.47912562
6mTOR signaling pathway_Homo sapiens_hsa041501.46367917
7Lysine degradation_Homo sapiens_hsa003101.46291006
8Long-term potentiation_Homo sapiens_hsa047201.42952742
9Adherens junction_Homo sapiens_hsa045201.39772831
10Chronic myeloid leukemia_Homo sapiens_hsa052201.38383003
11Glioma_Homo sapiens_hsa052141.36216992
12Endometrial cancer_Homo sapiens_hsa052131.35521552
13Phototransduction_Homo sapiens_hsa047441.34914527
14Pancreatic cancer_Homo sapiens_hsa052121.34309934
15Colorectal cancer_Homo sapiens_hsa052101.31049942
16MicroRNAs in cancer_Homo sapiens_hsa052061.28447129
17Non-small cell lung cancer_Homo sapiens_hsa052231.28132031
18ErbB signaling pathway_Homo sapiens_hsa040121.24950814
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23830342
20Circadian entrainment_Homo sapiens_hsa047131.23294184
21Dopaminergic synapse_Homo sapiens_hsa047281.21048145
22Renal cell carcinoma_Homo sapiens_hsa052111.20507102
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.17128581
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16145418
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15610436
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14564344
27Glutamatergic synapse_Homo sapiens_hsa047241.14450399
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13967251
29GnRH signaling pathway_Homo sapiens_hsa049121.12964607
30Estrogen signaling pathway_Homo sapiens_hsa049151.12907209
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12682725
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11054217
33Cholinergic synapse_Homo sapiens_hsa047251.09016754
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08436372
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08022929
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06581902
37Proteoglycans in cancer_Homo sapiens_hsa052051.06475597
38VEGF signaling pathway_Homo sapiens_hsa043701.06249148
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06142978
40Choline metabolism in cancer_Homo sapiens_hsa052311.05816746
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05051439
42Oxytocin signaling pathway_Homo sapiens_hsa049211.04627368
43cAMP signaling pathway_Homo sapiens_hsa040241.03166265
44Axon guidance_Homo sapiens_hsa043601.02282129
45Wnt signaling pathway_Homo sapiens_hsa043101.01255741
46Prolactin signaling pathway_Homo sapiens_hsa049171.00462820
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00111890
48Renin secretion_Homo sapiens_hsa049240.99681505
49Notch signaling pathway_Homo sapiens_hsa043300.99097082
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.98374063
51Insulin secretion_Homo sapiens_hsa049110.97234472
52Insulin resistance_Homo sapiens_hsa049310.97205468
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96607958
54Focal adhesion_Homo sapiens_hsa045100.96377230
55Amphetamine addiction_Homo sapiens_hsa050310.95320384
56Viral myocarditis_Homo sapiens_hsa054160.93648351
57Dilated cardiomyopathy_Homo sapiens_hsa054140.93385081
58Olfactory transduction_Homo sapiens_hsa047400.92886895
59ABC transporters_Homo sapiens_hsa020100.92584353
60Oocyte meiosis_Homo sapiens_hsa041140.92158412
61Prostate cancer_Homo sapiens_hsa052150.91944815
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91577789
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91464148
64Hippo signaling pathway_Homo sapiens_hsa043900.91183070
65Morphine addiction_Homo sapiens_hsa050320.90746082
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90738177
67MAPK signaling pathway_Homo sapiens_hsa040100.90716482
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90715931
69FoxO signaling pathway_Homo sapiens_hsa040680.90665796
70Long-term depression_Homo sapiens_hsa047300.89178900
71Cocaine addiction_Homo sapiens_hsa050300.88697269
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.88258232
73Gastric acid secretion_Homo sapiens_hsa049710.87771478
74Salivary secretion_Homo sapiens_hsa049700.86860655
75Melanogenesis_Homo sapiens_hsa049160.86453357
76Basal cell carcinoma_Homo sapiens_hsa052170.86249117
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86246975
78Osteoclast differentiation_Homo sapiens_hsa043800.86098486
79Small cell lung cancer_Homo sapiens_hsa052220.85786131
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85633048
81Ovarian steroidogenesis_Homo sapiens_hsa049130.85366516
82TGF-beta signaling pathway_Homo sapiens_hsa043500.84533456
83Platelet activation_Homo sapiens_hsa046110.82900800
84B cell receptor signaling pathway_Homo sapiens_hsa046620.82664186
85Synaptic vesicle cycle_Homo sapiens_hsa047210.82112255
86Taste transduction_Homo sapiens_hsa047420.81511566
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80669166
88Thyroid cancer_Homo sapiens_hsa052160.80558755
89Circadian rhythm_Homo sapiens_hsa047100.80010084
90Chemokine signaling pathway_Homo sapiens_hsa040620.79991652
91Rap1 signaling pathway_Homo sapiens_hsa040150.79420452
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79221269
93Serotonergic synapse_Homo sapiens_hsa047260.79091043
94T cell receptor signaling pathway_Homo sapiens_hsa046600.78592222
95GABAergic synapse_Homo sapiens_hsa047270.78472771
96Thyroid hormone synthesis_Homo sapiens_hsa049180.78339100
97Insulin signaling pathway_Homo sapiens_hsa049100.77883888
98Gap junction_Homo sapiens_hsa045400.76714920
99Hedgehog signaling pathway_Homo sapiens_hsa043400.76632612
100Toxoplasmosis_Homo sapiens_hsa051450.76428731
101Glucagon signaling pathway_Homo sapiens_hsa049220.75767579
102Acute myeloid leukemia_Homo sapiens_hsa052210.75526105
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75145374
104Hepatitis B_Homo sapiens_hsa051610.75020560
105AMPK signaling pathway_Homo sapiens_hsa041520.72091686
106Pathways in cancer_Homo sapiens_hsa052000.72030250
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71910364
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71702823
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.70393241
110Calcium signaling pathway_Homo sapiens_hsa040200.70000711
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69604044
112Ras signaling pathway_Homo sapiens_hsa040140.69172418
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.69041357
114Inositol phosphate metabolism_Homo sapiens_hsa005620.67993939
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67774493
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.62398625
117Melanoma_Homo sapiens_hsa052180.57998961
118Pancreatic secretion_Homo sapiens_hsa049720.52841213
119Ether lipid metabolism_Homo sapiens_hsa005650.52144241
120Sphingolipid metabolism_Homo sapiens_hsa006000.52141632
121Bile secretion_Homo sapiens_hsa049760.51334916

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