NCOA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Rap protein signal transduction (GO:0032486)4.34785016
2synaptic vesicle exocytosis (GO:0016079)4.33621903
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.19381203
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.09482189
5regulation of synaptic vesicle exocytosis (GO:2000300)3.98426394
6neuronal action potential propagation (GO:0019227)3.98147092
7positive regulation of synaptic transmission, GABAergic (GO:0032230)3.92072870
8synaptic vesicle maturation (GO:0016188)3.88334792
9negative regulation of complement activation (GO:0045916)3.85863328
10neuron cell-cell adhesion (GO:0007158)3.75426746
11glutamate secretion (GO:0014047)3.74914311
12negative regulation of dendrite morphogenesis (GO:0050774)3.73720092
13vocalization behavior (GO:0071625)3.70742917
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63928482
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54705429
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.54388143
17protein localization to synapse (GO:0035418)3.53137396
18locomotory exploration behavior (GO:0035641)3.51136548
19regulation of synaptic vesicle transport (GO:1902803)3.45538918
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41743233
21regulation of glutamate receptor signaling pathway (GO:1900449)3.41491977
22proline transport (GO:0015824)3.38057205
23negative regulation of protein activation cascade (GO:2000258)3.36779883
24neurotransmitter secretion (GO:0007269)3.24156985
25positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23094035
26negative regulation of humoral immune response (GO:0002921)3.19939331
27glutamate receptor signaling pathway (GO:0007215)3.14405832
28protein K11-linked deubiquitination (GO:0035871)3.13831569
29regulation of germinal center formation (GO:0002634)3.10143030
30exploration behavior (GO:0035640)3.08127416
31regulation of T-helper 1 cell differentiation (GO:0045625)3.07946172
32regulation of vesicle fusion (GO:0031338)3.07220800
33transepithelial transport (GO:0070633)3.03107632
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00828995
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.00609413
36gamma-aminobutyric acid signaling pathway (GO:0007214)2.94101128
37cerebellar Purkinje cell differentiation (GO:0021702)2.93308876
38neuron-neuron synaptic transmission (GO:0007270)2.90272586
39regulation of neuronal synaptic plasticity (GO:0048168)2.89995278
40synaptic transmission, glutamatergic (GO:0035249)2.89616417
41regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88297194
42cellular potassium ion homeostasis (GO:0030007)2.85986312
43negative regulation of T-helper cell differentiation (GO:0045623)2.84559995
44negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84559995
45membrane depolarization during action potential (GO:0086010)2.83089213
46cellular response to ethanol (GO:0071361)2.80092454
47long-term memory (GO:0007616)2.79936019
48regulation of postsynaptic membrane potential (GO:0060078)2.79718849
49synaptic vesicle endocytosis (GO:0048488)2.78967356
50presynaptic membrane assembly (GO:0097105)2.77508513
51cellular response to exogenous dsRNA (GO:0071360)2.75208021
52neurotransmitter transport (GO:0006836)2.74111190
53negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74074278
54regulation of neurotransmitter secretion (GO:0046928)2.72363011
55negative regulation of dendrite development (GO:2000171)2.71687635
56response to pain (GO:0048265)2.70376908
57regulation of synaptic transmission, GABAergic (GO:0032228)2.69751527
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69028970
59negative regulation of calcium ion transport into cytosol (GO:0010523)2.68787886
60postsynaptic membrane organization (GO:0001941)2.68079079
61membrane depolarization (GO:0051899)2.67507232
62positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.64710960
63regulation of memory T cell differentiation (GO:0043380)2.64252265
64regulation of interleukin-12 biosynthetic process (GO:0045075)2.64141085
65negative regulation of cell killing (GO:0031342)2.62425831
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62425831
67positive regulation of membrane potential (GO:0045838)2.60936268
68activation of protein kinase A activity (GO:0034199)2.60575473
69regulation of voltage-gated calcium channel activity (GO:1901385)2.59712813
70positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.58596407
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58139229
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.58045660
73detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.57820108
74detection of temperature stimulus involved in sensory perception (GO:0050961)2.57820108
75negative regulation of heart rate (GO:0010459)2.57488724
76regulation of protein kinase A signaling (GO:0010738)2.57404095
77regulation of synapse structural plasticity (GO:0051823)2.56593163
78interleukin-6-mediated signaling pathway (GO:0070102)2.56131297
79neuronal action potential (GO:0019228)2.55637337
80transmission of nerve impulse (GO:0019226)2.55104783
81cellular biogenic amine catabolic process (GO:0042402)2.55054578
82amine catabolic process (GO:0009310)2.55054578
83positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54266814
84regulation of T-helper cell differentiation (GO:0045622)2.53589801
85neuron recognition (GO:0008038)2.52581706
86interferon-gamma-mediated signaling pathway (GO:0060333)2.52577604
87vesicle transport along microtubule (GO:0047496)2.52555776
88regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.52547878
89synapse assembly (GO:0007416)2.52541533
90peripheral nervous system neuron development (GO:0048935)2.52483385
91natural killer cell activation involved in immune response (GO:0002323)2.51762173
92inositol phosphate-mediated signaling (GO:0048016)2.51731351
93gamma-aminobutyric acid transport (GO:0015812)2.51505665
94regulation of alpha-beta T cell proliferation (GO:0046640)2.51399479
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.50997280
96behavioral response to ethanol (GO:0048149)2.48735704
97synaptic vesicle transport (GO:0048489)2.48000114
98establishment of synaptic vesicle localization (GO:0097480)2.48000114
99regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.47400793
100presynaptic membrane organization (GO:0097090)2.47108799
101neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.47018555
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45979737
103regulation of amyloid precursor protein catabolic process (GO:1902991)2.45645198
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45634834
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45043686
106regulation of regulatory T cell differentiation (GO:0045589)2.44934558
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.44893832
108immunoglobulin mediated immune response (GO:0016064)2.43594537
109long-term synaptic potentiation (GO:0060291)2.43539383
110regulation of axon regeneration (GO:0048679)2.43380389
111regulation of neuron projection regeneration (GO:0070570)2.43380389
112positive regulation of transforming growth factor beta production (GO:0071636)2.42712779
113synaptic transmission (GO:0007268)2.42489843
114regulation of activation of Janus kinase activity (GO:0010533)2.41625046
115regulation of cell communication by electrical coupling (GO:0010649)2.41499126
116behavioral response to pain (GO:0048266)2.41448703
117regulation of synaptic plasticity (GO:0048167)2.41096865
118regulation of neurotransmitter transport (GO:0051588)2.41029390
119response to interferon-beta (GO:0035456)2.40979595
120regulation of neurotransmitter levels (GO:0001505)2.40344243
121positive regulation of neurotransmitter secretion (GO:0001956)2.40074037
122establishment of endothelial barrier (GO:0061028)2.40022708
123detection of calcium ion (GO:0005513)2.39561458
124innervation (GO:0060384)2.39532569
125positive regulation of T-helper cell differentiation (GO:0045624)2.39415773
126transferrin transport (GO:0033572)2.39414492
127positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.38956302
128cell migration in hindbrain (GO:0021535)2.38692129
129negative regulation of interleukin-17 production (GO:0032700)2.38339989
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38243289
131positive regulation of action potential (GO:0045760)2.37919747
132regulation of calcium ion-dependent exocytosis (GO:0017158)2.37372276
133calcium ion-dependent exocytosis (GO:0017156)2.37223998
134histamine transport (GO:0051608)2.36968044
135sensory perception of pain (GO:0019233)2.36191649
136negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.33370353
137negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.32916702
138production of molecular mediator of immune response (GO:0002440)2.32669250
139iron ion import (GO:0097286)2.32585307
140cellular response to interleukin-15 (GO:0071350)2.32026036
141regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.31280170
142CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.29027006
143T-helper cell differentiation (GO:0042093)2.29027006
144positive regulation of defense response to virus by host (GO:0002230)2.27917412
145histamine secretion (GO:0001821)2.27591791
146regulation of MHC class I biosynthetic process (GO:0045343)2.27243343
147positive regulation of toll-like receptor signaling pathway (GO:0034123)2.26870881
148regulation of interferon-alpha production (GO:0032647)2.26803662
149regulation of T-helper 1 type immune response (GO:0002825)2.26747947
150response to type I interferon (GO:0034340)2.26421502
151regulation of cellular extravasation (GO:0002691)2.25745946
152ER overload response (GO:0006983)2.24343726
153cytokine biosynthetic process (GO:0042089)2.24224391
154type I interferon signaling pathway (GO:0060337)2.23810366
155cellular response to type I interferon (GO:0071357)2.23810366
156positive regulation of protein autophosphorylation (GO:0031954)2.23682861
157response to interleukin-15 (GO:0070672)2.23513408
158positive regulation of macrophage differentiation (GO:0045651)2.22014823
159negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.21981905
160positive regulation of interferon-alpha production (GO:0032727)2.21584195
161sleep (GO:0030431)2.21338491
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.20835547
163regulation of gamma-delta T cell differentiation (GO:0045586)2.20675041
164lymph node development (GO:0048535)2.20664956
165negative regulation of bone resorption (GO:0045779)2.20405965
166negative regulation of cytokine secretion (GO:0050710)2.17832461
167positive regulation of interleukin-12 production (GO:0032735)2.16958742
168negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.16021993
169regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.15191542
170keratinocyte development (GO:0003334)2.14694254
171regulation of T cell receptor signaling pathway (GO:0050856)2.13859085
172regulation of macrophage chemotaxis (GO:0010758)2.13351247
173negative regulation of lipid storage (GO:0010888)2.13110686
174germinal center formation (GO:0002467)2.12896905
175regulation of transforming growth factor beta1 production (GO:0032908)2.12371864
176phospholipid translocation (GO:0045332)2.11974992
177lipid translocation (GO:0034204)2.11974992
178tryptophan catabolic process (GO:0006569)2.11839442
179indole-containing compound catabolic process (GO:0042436)2.11839442
180indolalkylamine catabolic process (GO:0046218)2.11839442
181regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.10041936
182negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.09141519
183nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.06991082
184retinal metabolic process (GO:0042574)2.06804164
185antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.05772123
186lipopolysaccharide-mediated signaling pathway (GO:0031663)2.05617324
187tolerance induction (GO:0002507)2.05265015
188cellular response to interferon-gamma (GO:0071346)2.05099711
189calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.05076869
190megakaryocyte development (GO:0035855)2.03896597
191response to muramyl dipeptide (GO:0032495)2.03046233
192antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.02998659
193I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.02933970
194regulation of T cell mediated cytotoxicity (GO:0001914)2.01990071
195positive regulation of type 2 immune response (GO:0002830)2.01283556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40554629
2GBX2_23144817_ChIP-Seq_PC3_Human3.63914499
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79228141
4TAF15_26573619_Chip-Seq_HEK293_Human2.66706150
5GATA1_22025678_ChIP-Seq_K562_Human2.59019530
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56798944
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56457275
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.48490944
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40780087
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.34500311
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.33277053
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29804984
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28795517
14IGF1R_20145208_ChIP-Seq_DFB_Human2.24804032
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23426387
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23137527
17REST_21632747_ChIP-Seq_MESCs_Mouse2.18734045
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17355447
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16962733
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13018870
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12226102
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10608735
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08191757
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08191757
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08075770
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01203379
27* P300_19829295_ChIP-Seq_ESCs_Human1.98635253
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.96009049
29SMAD4_21799915_ChIP-Seq_A2780_Human1.95374620
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90997956
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.86260953
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85541652
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.85298171
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.83872210
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83870734
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82743536
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80873312
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78245563
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.76593689
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75632849
41DROSHA_22980978_ChIP-Seq_HELA_Human1.73628965
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66508032
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.65642462
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.64380327
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.63683391
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61676335
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59969143
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.58345163
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.56961771
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56535386
51* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55478809
52* CJUN_26792858_Chip-Seq_BT549_Human1.53817312
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53282371
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53043355
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51832078
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51208622
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.47414684
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47210257
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46532733
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.45878474
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44785563
62AR_25329375_ChIP-Seq_VCAP_Human1.44159919
63VDR_24787735_ChIP-Seq_THP-1_Human1.43474694
64AR_21572438_ChIP-Seq_LNCaP_Human1.43373898
65TP53_16413492_ChIP-PET_HCT116_Human1.43031519
66* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42081111
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36245647
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35911171
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35911171
70* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35608786
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35364796
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35104861
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.35097330
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.34813444
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32487799
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.32077173
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.30940364
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30780203
79* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30346958
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29963706
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.28996356
82STAT3_23295773_ChIP-Seq_U87_Human1.28851428
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.27839329
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27437812
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27053662
86* PRDM14_20953172_ChIP-Seq_ESCs_Human1.25611081
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24352851
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23976819
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23777072
90SOX2_20726797_ChIP-Seq_SW620_Human1.21789094
91ER_23166858_ChIP-Seq_MCF-7_Human1.21371993
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.21285240
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20336015
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19977539
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19786128
96MYB_26560356_Chip-Seq_TH2_Human1.19722121
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19661665
98GATA4_25053715_ChIP-Seq_YYC3_Human1.19229509
99TP53_18474530_ChIP-ChIP_U2OS_Human1.19217948
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.19007727
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18783941
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18516121
103SCL_19346495_ChIP-Seq_HPC-7_Human1.18109880
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17957054
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17783790
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17498775
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.16971354
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16638548
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.16524253
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.16247716
111LXR_22158963_ChIP-Seq_LIVER_Mouse1.15832168
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15822410
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13857669
114RNF2_27304074_Chip-Seq_NSC_Mouse1.13801207
115* GATA3_26560356_Chip-Seq_TH2_Human1.13699461
116CDX2_22108803_ChIP-Seq_LS180_Human1.11075149
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11062129
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09757855
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.09140031
120RUNX2_22187159_ChIP-Seq_PCA_Human1.08055786
121AHR_22903824_ChIP-Seq_MCF-7_Human1.07888765
122TCF4_23295773_ChIP-Seq_U87_Human1.07628449
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07492355
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07071127
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.06824967
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05982987
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.05948833
128* TP63_23658742_ChIP-Seq_EP156T_Human1.05295184
129* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05090614
130* EZH2_27294783_Chip-Seq_NPCs_Mouse1.05055603
131KDM2B_26808549_Chip-Seq_REH_Human1.04576311
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03215495
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02430885
134SMRT_27268052_Chip-Seq_Bcells_Human1.02337677
135* FUS_26573619_Chip-Seq_HEK293_Human1.01758425
136VDR_22108803_ChIP-Seq_LS180_Human1.01711138
137JUN_21703547_ChIP-Seq_K562_Human1.01478872
138EP300_21415370_ChIP-Seq_HL-1_Mouse1.01187374
139NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01092731
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00999520
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00085187
142* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00056998
143RUNX_20019798_ChIP-Seq_JUKART_Human0.99217095
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98996286
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98446218
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.97982705
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.97226741
148RXR_22108803_ChIP-Seq_LS180_Human0.97134663
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97046674
150P53_22387025_ChIP-Seq_ESCs_Mouse0.97035068
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96541173
152SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96324111
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96212105
154* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95953268
155FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95074313
156NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94749420
157MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94701898
158STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94497092
159SOX2_18555785_Chip-Seq_ESCs_Mouse0.94448285
160KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94417733
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93941398
162JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93824432
163* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93223593
164* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93223593
165BCAT_22108803_ChIP-Seq_LS180_Human0.93154818
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92882635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.34936751
2MP0003880_abnormal_central_pattern3.96642797
3MP0002735_abnormal_chemical_nociception3.75233270
4MP0001968_abnormal_touch/_nociception3.56911764
5MP0003300_gastrointestinal_ulcer3.48050562
6MP0004270_analgesia3.46565437
7MP0003635_abnormal_synaptic_transmissio3.20118834
8MP0002736_abnormal_nociception_after2.90681351
9MP0009745_abnormal_behavioral_response2.86052835
10MP0002734_abnormal_mechanical_nocicepti2.85517538
11MP0010386_abnormal_urinary_bladder2.67524954
12MP0009046_muscle_twitch2.61324798
13MP0002064_seizures2.56031161
14MP0003303_peritoneal_inflammation2.51050792
15MP0002063_abnormal_learning/memory/cond2.49750140
16MP0002733_abnormal_thermal_nociception2.39059038
17MP0006276_abnormal_autonomic_nervous2.37790091
18MP0003950_abnormal_plasma_membrane2.37627053
19MP0001970_abnormal_pain_threshold2.35541564
20MP0002572_abnormal_emotion/affect_behav2.32249628
21MP0002272_abnormal_nervous_system2.31324622
22MP0001501_abnormal_sleep_pattern2.31162385
23MP0001986_abnormal_taste_sensitivity2.25953852
24MP0005423_abnormal_somatic_nervous2.18466877
25MP0001873_stomach_inflammation2.14605363
26MP0005670_abnormal_white_adipose2.14380544
27MP0003436_decreased_susceptibility_to2.11424169
28MP0001440_abnormal_grooming_behavior2.05376204
29MP0002822_catalepsy1.93587552
30MP0002067_abnormal_sensory_capabilities1.93193717
31MP0008004_abnormal_stomach_pH1.88291393
32MP0004858_abnormal_nervous_system1.85303876
33MP0001800_abnormal_humoral_immune1.76004888
34MP0003195_calcinosis1.72654447
35MP0004510_myositis1.71391598
36MP0010352_gastrointestinal_tract_polyps1.70906666
37MP0004043_abnormal_pH_regulation1.70024008
38MP0002184_abnormal_innervation1.66056425
39MP0001188_hyperpigmentation1.66019586
40MP0003252_abnormal_bile_duct1.64813551
41MP0001486_abnormal_startle_reflex1.64722056
42MP0004782_abnormal_surfactant_physiolog1.62588564
43MP0004924_abnormal_behavior1.61434815
44MP0005386_behavior/neurological_phenoty1.61434815
45MP0005166_decreased_susceptibility_to1.60908473
46MP0008875_abnormal_xenobiotic_pharmacok1.59319858
47MP0009764_decreased_sensitivity_to1.57997473
48MP0001348_abnormal_lacrimal_gland1.57603634
49MP0002163_abnormal_gland_morphology1.56334703
50MP0000569_abnormal_digit_pigmentation1.54135406
51MP0004947_skin_inflammation1.54020549
52MP0002452_abnormal_antigen_presenting1.52062774
53MP0010155_abnormal_intestine_physiology1.51412661
54MP0008569_lethality_at_weaning1.50108554
55MP0005025_abnormal_response_to1.44760316
56MP0009780_abnormal_chondrocyte_physiolo1.43014664
57MP0003656_abnormal_erythrocyte_physiolo1.41992246
58MP0001905_abnormal_dopamine_level1.41734684
59MP0003763_abnormal_thymus_physiology1.41196724
60MP0009840_abnormal_foam_cell1.40062382
61MP0003787_abnormal_imprinting1.39523211
62MP0004811_abnormal_neuron_physiology1.37613830
63MP0001835_abnormal_antigen_presentation1.37394079
64MP0002557_abnormal_social/conspecific_i1.36381792
65MP0008057_abnormal_DNA_replication1.35095367
66MP0000465_gastrointestinal_hemorrhage1.34847163
67MP0003879_abnormal_hair_cell1.32715631
68MP0005083_abnormal_biliary_tract1.31088138
69MP0001851_eye_inflammation1.29979409
70MP0005310_abnormal_salivary_gland1.29709973
71MP0005379_endocrine/exocrine_gland_phen1.29385586
72MP0001533_abnormal_skeleton_physiology1.28440834
73MP0001845_abnormal_inflammatory_respons1.28240396
74MP0001984_abnormal_olfaction1.28168074
75MP0002148_abnormal_hypersensitivity_rea1.26810598
76MP0005023_abnormal_wound_healing1.26576567
77MP0003183_abnormal_peptide_metabolism1.26351494
78MP0009785_altered_susceptibility_to1.26005008
79MP0005671_abnormal_response_to1.25527255
80MP0000613_abnormal_salivary_gland1.25444187
81MP0002405_respiratory_system_inflammati1.24219247
82MP0005365_abnormal_bile_salt1.19239731
83MP0001666_abnormal_nutrient_absorption1.18653559
84MP0002909_abnormal_adrenal_gland1.16622202
85MP0001529_abnormal_vocalization1.16232568
86MP0001502_abnormal_circadian_rhythm1.15221836
87MP0005164_abnormal_response_to1.13164899
88MP0003633_abnormal_nervous_system1.13161106
89MP0000778_abnormal_nervous_system1.12885530
90MP0005645_abnormal_hypothalamus_physiol1.12415025
91MP0000955_abnormal_spinal_cord1.10929793
92MP0002139_abnormal_hepatobiliary_system1.09377824
93MP0005535_abnormal_body_temperature1.07967961
94MP0000015_abnormal_ear_pigmentation1.07563384
95MP0001853_heart_inflammation1.06743369
96MP0002066_abnormal_motor_capabilities/c1.03062481
97MP0002638_abnormal_pupillary_reflex1.02534917
98MP0002882_abnormal_neuron_morphology1.01330348
99MP0005000_abnormal_immune_tolerance1.01017092
100MP0008872_abnormal_physiological_respon1.00451340
101MP0003724_increased_susceptibility_to1.00427534
102MP0003868_abnormal_feces_composition1.00211577
103MP0001545_abnormal_hematopoietic_system0.99847690
104MP0005397_hematopoietic_system_phenotyp0.99847690
105MP0005220_abnormal_exocrine_pancreas0.98626028
106MP0004147_increased_porphyrin_level0.98254300
107MP0005646_abnormal_pituitary_gland0.96552699
108MP0004742_abnormal_vestibular_system0.95152447
109MP0002132_abnormal_respiratory_system0.94492754
110MP0000716_abnormal_immune_system0.92744484
111MP0001790_abnormal_immune_system0.92417507
112MP0005387_immune_system_phenotype0.92417507
113MP0004142_abnormal_muscle_tone0.92370784
114MP0005464_abnormal_platelet_physiology0.92121167
115MP0003828_pulmonary_edema0.91931337
116MP0009765_abnormal_xenobiotic_induced0.91151818
117MP0003122_maternal_imprinting0.91078791
118MP0008961_abnormal_basal_metabolism0.90147223
119MP0003631_nervous_system_phenotype0.90033834
120MP0002168_other_aberrant_phenotype0.89624854
121MP0002751_abnormal_autonomic_nervous0.89222559
122MP0008874_decreased_physiological_sensi0.88419245
123MP0008469_abnormal_protein_level0.88205334
124MP0006082_CNS_inflammation0.88020605
125MP0009379_abnormal_foot_pigmentation0.87998035
126MP0002398_abnormal_bone_marrow0.86754401
127MP0001756_abnormal_urination0.86126925
128MP0003075_altered_response_to0.85246564
129MP0002928_abnormal_bile_duct0.84572049
130MP0008873_increased_physiological_sensi0.82751383
131MP0003045_fibrosis0.81832490
132MP0009643_abnormal_urine_homeostasis0.81753272
133MP0002998_abnormal_bone_remodeling0.81739302
134MP0005409_darkened_coat_color0.81682723
135MP0002136_abnormal_kidney_physiology0.81086846
136MP0003329_amyloid_beta_deposits0.81034744
137MP0000343_altered_response_to0.80560009
138MP0000920_abnormal_myelination0.79523149
139MP0005410_abnormal_fertilization0.78891110
140MP0002876_abnormal_thyroid_physiology0.78821729
141MP0003091_abnormal_cell_migration0.77433313
142MP0005165_increased_susceptibility_to0.76803104
143MP0001663_abnormal_digestive_system0.75765646
144MP0003448_altered_tumor_morphology0.73475977
145MP0003866_abnormal_defecation0.73359520
146MP0005167_abnormal_blood-brain_barrier0.71636480
147MP0002009_preneoplasia0.71070145
148MP0002723_abnormal_immune_serum0.69809655
149MP0002229_neurodegeneration0.68249475
150MP0005171_absent_coat_pigmentation0.68192560
151MP0000685_abnormal_immune_system0.66328367
152MP0002006_tumorigenesis0.65446805
153MP0000538_abnormal_urinary_bladder0.65158343
154MP0005174_abnormal_tail_pigmentation0.64984547
155MP0001765_abnormal_ion_homeostasis0.63651236
156MP0002138_abnormal_hepatobiliary_system0.62194033
157MP0001819_abnormal_immune_cell0.61796639
158MP0002277_abnormal_respiratory_mucosa0.60765834
159MP0002166_altered_tumor_susceptibility0.60300895
160MP0002069_abnormal_eating/drinking_beha0.60265442
161MP0004484_altered_response_of0.60200004
162MP0002420_abnormal_adaptive_immunity0.60112559
163MP0004883_abnormal_blood_vessel0.58178176
164MP0004885_abnormal_endolymph0.57953997
165MP0002419_abnormal_innate_immunity0.57928418

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.22400058
2Myokymia (HP:0002411)5.59341221
3Visual hallucinations (HP:0002367)4.79284902
4Atonic seizures (HP:0010819)4.73315621
5Febrile seizures (HP:0002373)4.71896428
6Focal seizures (HP:0007359)4.69147846
7Stomach cancer (HP:0012126)4.46965552
8Progressive cerebellar ataxia (HP:0002073)4.21933702
9Epileptic encephalopathy (HP:0200134)4.20595053
10Hypothermia (HP:0002045)3.89206489
11Absence seizures (HP:0002121)3.78283568
12Alopecia of scalp (HP:0002293)3.55231576
13Alveolar cell carcinoma (HP:0006519)3.55214222
14Dialeptic seizures (HP:0011146)3.53137479
15Neoplasm of the tracheobronchial system (HP:0100552)3.35593225
16Generalized tonic-clonic seizures (HP:0002069)3.25070158
17Action tremor (HP:0002345)3.20587740
18Hypokalemic alkalosis (HP:0001949)3.15263557
19Retrobulbar optic neuritis (HP:0100654)3.14818560
20Optic neuritis (HP:0100653)3.14818560
21Stomatitis (HP:0010280)3.12591658
22Papilledema (HP:0001085)3.07363528
23Elevated erythrocyte sedimentation rate (HP:0003565)3.03288743
24Abnormality of chloride homeostasis (HP:0011422)3.00910603
25Steatorrhea (HP:0002570)3.00127397
26Exocrine pancreatic insufficiency (HP:0001738)2.99943510
27Amblyopia (HP:0000646)2.97561363
28Neuroendocrine neoplasm (HP:0100634)2.94957977
29Peripheral hypomyelination (HP:0007182)2.88940392
30Abnormal hair whorl (HP:0010721)2.88684451
31Follicular hyperkeratosis (HP:0007502)2.85783486
32Pheochromocytoma (HP:0002666)2.84623013
33Supranuclear gaze palsy (HP:0000605)2.82513757
34Progressive inability to walk (HP:0002505)2.80197842
35Autoimmune hemolytic anemia (HP:0001890)2.72938251
36Truncal ataxia (HP:0002078)2.70089634
37Gaze-evoked nystagmus (HP:0000640)2.63600091
38Interstitial pulmonary disease (HP:0006530)2.62716914
39Metabolic alkalosis (HP:0200114)2.62297249
40Limb dystonia (HP:0002451)2.61550186
41Anxiety (HP:0000739)2.59714819
42Facial shape deformation (HP:0011334)2.59037899
43Potter facies (HP:0002009)2.59037899
44Orchitis (HP:0100796)2.54040095
45Abnormality of the prostate (HP:0008775)2.53388602
46Abnormality of dental color (HP:0011073)2.50482711
47Widely spaced teeth (HP:0000687)2.50025298
48Prostate neoplasm (HP:0100787)2.47104373
49Depression (HP:0000716)2.44346917
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.42510237
51Abnormality of the nasal septum (HP:0000419)2.42406368
52Hyperventilation (HP:0002883)2.41078034
53Scanning speech (HP:0002168)2.40997556
54Fat malabsorption (HP:0002630)2.39161319
55Broad-based gait (HP:0002136)2.38642772
56Ulnar claw (HP:0001178)2.35494551
57Recurrent bronchitis (HP:0002837)2.33535688
58Increased IgM level (HP:0003496)2.31185280
59Dysmetric saccades (HP:0000641)2.31121474
60Abnormal eating behavior (HP:0100738)2.30055720
61Slow saccadic eye movements (HP:0000514)2.28465370
62Myositis (HP:0100614)2.27706367
63Joint swelling (HP:0001386)2.25487953
64Abnormality of the renal cortex (HP:0011035)2.25420542
65Hypoproteinemia (HP:0003075)2.23916549
66Erythema (HP:0010783)2.23252526
67Hyperaldosteronism (HP:0000859)2.22888675
68Autoimmune thrombocytopenia (HP:0001973)2.20121717
69Failure to thrive in infancy (HP:0001531)2.20084833
70Abnormality of binocular vision (HP:0011514)2.19979666
71Diplopia (HP:0000651)2.19979666
72Agitation (HP:0000713)2.19764406
73Gait imbalance (HP:0002141)2.18881660
74Impaired smooth pursuit (HP:0007772)2.17491072
75Anhidrosis (HP:0000970)2.17125811
76Vascular calcification (HP:0004934)2.16921202
77Poor eye contact (HP:0000817)2.14556556
78Chronic diarrhea (HP:0002028)2.11287890
79Urinary bladder sphincter dysfunction (HP:0002839)2.11287301
80Increased CSF protein (HP:0002922)2.11274803
81Decreased circulating renin level (HP:0003351)2.10895568
82Abnormality of B cell number (HP:0010975)2.10885741
83Glomerulonephritis (HP:0000099)2.10769002
84Chronic otitis media (HP:0000389)2.10751728
85Abnormality of the right ventricle (HP:0001707)2.10446882
86Menstrual irregularities (HP:0000858)2.10101566
87Genetic anticipation (HP:0003743)2.09678024
88Hyperactive renin-angiotensin system (HP:0000841)2.09462816
89Neoplasm of the peripheral nervous system (HP:0100007)2.08218536
90Heterochromia iridis (HP:0001100)2.07465603
91Dysautonomia (HP:0002459)2.07124595
92Cerebral hemorrhage (HP:0001342)2.06115564
93Dysmetria (HP:0001310)2.05975638
94Hypercortisolism (HP:0001578)2.05851981
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05788505
96Psychosis (HP:0000709)2.05661556
97Abnormal autonomic nervous system physiology (HP:0012332)2.02731978
98Abnormality of the corticospinal tract (HP:0002492)2.01745897
99Hypoventilation (HP:0002791)2.00966798
100Protruding tongue (HP:0010808)2.00332449
101Azoospermia (HP:0000027)2.00245209
102Fair hair (HP:0002286)1.99847495
103Abnormality of T cell number (HP:0011839)1.99743563
104Nephritis (HP:0000123)1.99504823
105Abnormality of the periventricular white matter (HP:0002518)1.98338140
106Blue irides (HP:0000635)1.97466671
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.97436472
108Ankle clonus (HP:0011448)1.95566493
109Inability to walk (HP:0002540)1.95499100
110Cardiovascular calcification (HP:0011915)1.95362894
111Absent/shortened dynein arms (HP:0200106)1.95139132
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.95139132
113Genital tract atresia (HP:0001827)1.94599912
114Thyroid carcinoma (HP:0002890)1.94277470
115Impaired vibration sensation in the lower limbs (HP:0002166)1.94096574
116Metaphyseal dysplasia (HP:0100255)1.93975185
117Inappropriate behavior (HP:0000719)1.93722145
118Systemic lupus erythematosus (HP:0002725)1.93500103
119Abnormality of renin-angiotensin system (HP:0000847)1.93397621
120Alkalosis (HP:0001948)1.93123100
121Abnormality of male internal genitalia (HP:0000022)1.92991892
122Mutism (HP:0002300)1.92123685
123Cone-rod dystrophy (HP:0000548)1.91860456
124Bradykinesia (HP:0002067)1.90976669
125Drooling (HP:0002307)1.90917362
126Excessive salivation (HP:0003781)1.90917362
127Congenital primary aphakia (HP:0007707)1.90632369
128Hemiparesis (HP:0001269)1.89227685
129Abnormality of calcium-phosphate metabolism (HP:0100530)1.88665429
130Vaginal atresia (HP:0000148)1.88642290
131Ileus (HP:0002595)1.87911948
132Abnormality of T cell physiology (HP:0011840)1.87677463
133Spinal canal stenosis (HP:0003416)1.87563303
134Medial flaring of the eyebrow (HP:0010747)1.87149958
135Keratoconjunctivitis sicca (HP:0001097)1.86680733
136Glucose intolerance (HP:0000833)1.85940406
137Petechiae (HP:0000967)1.85627617
138Absent speech (HP:0001344)1.85382723
139Stereotypic behavior (HP:0000733)1.84892458
140Polyphagia (HP:0002591)1.84494540
141Generalized hypopigmentation of hair (HP:0011358)1.84431543
142Vasculitis (HP:0002633)1.84161985
143Myotonia (HP:0002486)1.83081586
144Conical tooth (HP:0000698)1.82526994
145Nephrogenic diabetes insipidus (HP:0009806)1.82384964
146Increased circulating renin level (HP:0000848)1.81995620
147Dysdiadochokinesis (HP:0002075)1.80985264
148Abnormality of salivation (HP:0100755)1.80136264
149Pulmonary fibrosis (HP:0002206)1.79504924
150Pancreatitis (HP:0001733)1.79399701
151Abnormality of saccadic eye movements (HP:0000570)1.78545978
152Keratitis (HP:0000491)1.78229680
153Tubulointerstitial fibrosis (HP:0005576)1.78089984
154Sparse eyelashes (HP:0000653)1.77543378
155Abnormal biliary tract morphology (HP:0012440)1.77203930
156Arterial tortuosity (HP:0005116)1.77197490
157Epileptiform EEG discharges (HP:0011182)1.75610979
158Abnormality of the pleura (HP:0002103)1.75512925
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75447401
160Abnormal social behavior (HP:0012433)1.74651352
161Impaired social interactions (HP:0000735)1.74651352
162Renal salt wasting (HP:0000127)1.74535021
163Orthostatic hypotension (HP:0001278)1.73868869
164Subacute progressive viral hepatitis (HP:0006572)1.73314807
165Lip pit (HP:0100267)1.73110543
166Prolonged bleeding time (HP:0003010)1.72858154
167Pulmonary infiltrates (HP:0002113)1.71862677
168Akinesia (HP:0002304)1.71802945
169Fetal akinesia sequence (HP:0001989)1.71619005
170Hypomagnesemia (HP:0002917)1.69679467
171Keratoconjunctivitis (HP:0001096)1.69067500
172Termporal pattern (HP:0011008)1.68026398
173Insidious onset (HP:0003587)1.68026398
174Specific learning disability (HP:0001328)1.64825393
175Recurrent abscess formation (HP:0002722)1.64389464
176Urinary urgency (HP:0000012)1.63785785
177Nuclear cataract (HP:0100018)1.62922926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.43494552
2NTRK34.03790956
3MAP3K123.86989631
4RIPK43.52719667
5TAOK33.02964510
6STK392.73684579
7MINK12.53849991
8MAP2K72.43382538
9EPHA22.36689562
10CASK2.28012899
11GRK52.26495930
12MAP3K42.21245159
13MAP3K92.16277391
14NTRK12.14997676
15GRK12.09305651
16EIF2AK32.06725984
17BMPR22.03220084
18KSR22.00225135
19MAP3K141.96194305
20MAP3K21.91178474
21BRSK21.81987735
22EPHA41.78669861
23SIK31.72832828
24PLK21.69323725
25MARK11.67906559
26DAPK21.66962889
27MAPK131.60434300
28DAPK11.60406196
29SIK21.52920265
30PTK2B1.50758463
31BMPR1B1.49703376
32MAP2K41.49448884
33ADRBK21.48327474
34STK38L1.43004554
35CAMKK21.40272810
36FES1.37474837
37PIK3CA1.35487864
38TNIK1.31500911
39RET1.31352096
40ARAF1.25744957
41STK31.24965941
42TXK1.21564557
43CDK191.20626832
44MAP3K131.19687106
45ITK1.18739799
46SGK21.17657289
47CHUK1.15608731
48STK381.15268768
49RIPK11.15038670
50TGFBR21.14077631
51CDK51.13390927
52MAP3K31.11013141
53NTRK21.09344633
54MATK1.07945623
55TYK21.06805872
56KIT1.06227319
57MST41.04754731
58SYK1.04061967
59BTK1.01915233
60MST1R1.01576022
61WNK10.99899152
62TRPM70.99540846
63FRK0.99301095
64TNK20.98791265
65PNCK0.97857914
66IRAK10.97193637
67PRKG20.96242756
68SGK2230.92873322
69SGK4940.92873322
70IKBKE0.92030028
71OXSR10.91819363
72PRKCE0.87775628
73MAP3K10.86167516
74PAK60.85435098
75GRK70.82705774
76EIF2AK20.82534664
77UHMK10.82154330
78PDK20.81206739
79GRK60.80597840
80MET0.80590235
81CAMKK10.79593542
82JAK10.79161021
83MAPKAPK30.78677823
84JAK30.77533662
85TBK10.77087880
86WNK30.76673716
87STK100.76582413
88SGK30.73484877
89CAMK2A0.72127472
90WNK40.70426938
91MAPKAPK50.67716185
92FGFR30.67233704
93ADRBK10.66961143
94PRKCG0.66599791
95PRPF4B0.66102114
96RPS6KA20.63264598
97ZAP700.61389895
98IKBKB0.61234606
99NUAK10.60700206
100NEK60.58855221
101YES10.58524017
102KSR10.58318331
103PINK10.57686451
104ABL10.57185355
105NLK0.56675333
106MAPK70.56459301
107LIMK10.56021218
108AKT30.55615907
109TRIM280.55249056
110EPHA30.55028533
111INSRR0.54574246
112CDK80.53956004
113HIPK20.52918649
114HCK0.52497257
115SGK10.52376469
116FGR0.51940167
117MAPK110.51185393
118MAP4K10.51167522
119RAF10.51017294
120LATS10.49720219
121MAP2K10.48995975
122PAK30.48495865
123BCR0.48272214
124CAMK2B0.46809174
125CDK140.45396303
126MAP3K70.45187852
127PDK10.44141654
128PRKAA20.42672406
129CDK180.42176124
130MELK0.41660048
131ERBB30.41609169
132FER0.40989187
133PRKCH0.40722174
134BLK0.40611701
135MAP2K60.39672382
136IGF1R0.39613674
137MAP2K20.38989801
138PRKCQ0.38646524
139STK240.37800156
140CAMK10.37639671
141JAK20.36059705
142MAPK40.35896404
143MYLK0.34902347
144ERN10.33897962
145CDK150.33615024
146PRKCD0.33592797
147CAMK2D0.33342631
148TEC0.32239103
149FYN0.32008687
150LCK0.31728672
151STK110.30900912
152PRKD30.29349873
153SCYL20.29023741

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.67145340
2Nicotine addiction_Homo sapiens_hsa050332.63288879
3Long-term potentiation_Homo sapiens_hsa047202.08910253
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07340590
5Asthma_Homo sapiens_hsa053101.97987093
6Collecting duct acid secretion_Homo sapiens_hsa049661.97780514
7Circadian entrainment_Homo sapiens_hsa047131.97027439
8Morphine addiction_Homo sapiens_hsa050321.92331870
9Olfactory transduction_Homo sapiens_hsa047401.87057389
10GABAergic synapse_Homo sapiens_hsa047271.87041032
11Glutamatergic synapse_Homo sapiens_hsa047241.84378683
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84011190
13Circadian rhythm_Homo sapiens_hsa047101.81096680
14Amphetamine addiction_Homo sapiens_hsa050311.78428090
15Taste transduction_Homo sapiens_hsa047421.78248438
16Dopaminergic synapse_Homo sapiens_hsa047281.67238099
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67183900
18Type I diabetes mellitus_Homo sapiens_hsa049401.67131759
19Cholinergic synapse_Homo sapiens_hsa047251.62881059
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.62173582
21Salivary secretion_Homo sapiens_hsa049701.60548339
22Serotonergic synapse_Homo sapiens_hsa047261.59885399
23Insulin secretion_Homo sapiens_hsa049111.57384839
24Renin secretion_Homo sapiens_hsa049241.50484663
25Hepatitis C_Homo sapiens_hsa051601.46346905
26Long-term depression_Homo sapiens_hsa047301.43330360
27Gastric acid secretion_Homo sapiens_hsa049711.40059254
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.37185683
29Staphylococcus aureus infection_Homo sapiens_hsa051501.36983570
30Rheumatoid arthritis_Homo sapiens_hsa053231.36676693
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35284498
32Allograft rejection_Homo sapiens_hsa053301.32686107
33Nitrogen metabolism_Homo sapiens_hsa009101.31584373
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31443870
35Type II diabetes mellitus_Homo sapiens_hsa049301.29394104
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28814166
37Cocaine addiction_Homo sapiens_hsa050301.24350856
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24053136
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19741487
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18617711
41Vibrio cholerae infection_Homo sapiens_hsa051101.18103698
42Oxytocin signaling pathway_Homo sapiens_hsa049211.17977837
43African trypanosomiasis_Homo sapiens_hsa051431.16251966
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13471737
45Hematopoietic cell lineage_Homo sapiens_hsa046401.12360319
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12295093
47Calcium signaling pathway_Homo sapiens_hsa040201.09162742
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09092835
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08247981
50GnRH signaling pathway_Homo sapiens_hsa049121.06472280
51Mineral absorption_Homo sapiens_hsa049781.04172209
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.03464962
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01165978
54Malaria_Homo sapiens_hsa051440.99751537
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.98353905
56Graft-versus-host disease_Homo sapiens_hsa053320.97986028
57cAMP signaling pathway_Homo sapiens_hsa040240.97475248
58Linoleic acid metabolism_Homo sapiens_hsa005910.97143310
59Legionellosis_Homo sapiens_hsa051340.97100908
60Estrogen signaling pathway_Homo sapiens_hsa049150.96227272
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94945374
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94804331
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93334790
64Glioma_Homo sapiens_hsa052140.92950931
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92262063
66Sphingolipid metabolism_Homo sapiens_hsa006000.92155548
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91710286
68Chemokine signaling pathway_Homo sapiens_hsa040620.90799466
69Herpes simplex infection_Homo sapiens_hsa051680.90287966
70Caffeine metabolism_Homo sapiens_hsa002320.90179040
71Complement and coagulation cascades_Homo sapiens_hsa046100.89115989
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88590038
73Prolactin signaling pathway_Homo sapiens_hsa049170.88509148
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.87886499
75Chemical carcinogenesis_Homo sapiens_hsa052040.87425761
76ErbB signaling pathway_Homo sapiens_hsa040120.84530339
77Osteoclast differentiation_Homo sapiens_hsa043800.84236067
78Leishmaniasis_Homo sapiens_hsa051400.84218435
79Salmonella infection_Homo sapiens_hsa051320.84119952
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83799429
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83788297
82Dorso-ventral axis formation_Homo sapiens_hsa043200.83679421
83Gap junction_Homo sapiens_hsa045400.83676902
84ABC transporters_Homo sapiens_hsa020100.82088341
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80750839
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79691322
87Primary immunodeficiency_Homo sapiens_hsa053400.79635537
88TNF signaling pathway_Homo sapiens_hsa046680.78823403
89Retinol metabolism_Homo sapiens_hsa008300.78627480
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77757765
91MAPK signaling pathway_Homo sapiens_hsa040100.77609858
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76995691
93Alzheimers disease_Homo sapiens_hsa050100.75308184
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74607494
95Phagosome_Homo sapiens_hsa041450.74393359
96Arachidonic acid metabolism_Homo sapiens_hsa005900.73491144
97Oxidative phosphorylation_Homo sapiens_hsa001900.73100877
98Bile secretion_Homo sapiens_hsa049760.72253939
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71845467
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71107680
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71047380
102Tuberculosis_Homo sapiens_hsa051520.70629844
103Tryptophan metabolism_Homo sapiens_hsa003800.69465185
104Pertussis_Homo sapiens_hsa051330.69184516
105T cell receptor signaling pathway_Homo sapiens_hsa046600.68892023
106Histidine metabolism_Homo sapiens_hsa003400.68174355
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.66843904
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66228934
109Cardiac muscle contraction_Homo sapiens_hsa042600.66133049
110B cell receptor signaling pathway_Homo sapiens_hsa046620.65896365
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65626836
112Pancreatic secretion_Homo sapiens_hsa049720.65472292
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.65401104
114VEGF signaling pathway_Homo sapiens_hsa043700.64990662
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64654842
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64625902
117Autoimmune thyroid disease_Homo sapiens_hsa053200.63575088
118Choline metabolism in cancer_Homo sapiens_hsa052310.62681551
119Sulfur metabolism_Homo sapiens_hsa009200.62124993
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61542463
121Axon guidance_Homo sapiens_hsa043600.61356796
122Platelet activation_Homo sapiens_hsa046110.61097141
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60585923
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.58789377
125Melanogenesis_Homo sapiens_hsa049160.58552548
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.58009287
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57677533
128Ras signaling pathway_Homo sapiens_hsa040140.57409675
129Thyroid hormone synthesis_Homo sapiens_hsa049180.57111228
130Inositol phosphate metabolism_Homo sapiens_hsa005620.56805389
131Antigen processing and presentation_Homo sapiens_hsa046120.56725268
132Toxoplasmosis_Homo sapiens_hsa051450.56175773
133Measles_Homo sapiens_hsa051620.53374607
134Parkinsons disease_Homo sapiens_hsa050120.52847749
135Influenza A_Homo sapiens_hsa051640.52343332
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51350050
137Hepatitis B_Homo sapiens_hsa051610.50764857
138Ether lipid metabolism_Homo sapiens_hsa005650.50185096
139Glycerolipid metabolism_Homo sapiens_hsa005610.47029581
140Amoebiasis_Homo sapiens_hsa051460.46829123
141Protein digestion and absorption_Homo sapiens_hsa049740.45543915
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44565656
143Acute myeloid leukemia_Homo sapiens_hsa052210.42996412

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