NCOR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)6.48131317
2cellular extravasation (GO:0045123)5.28281874
3regulation of MHC class II biosynthetic process (GO:0045346)5.04438327
4N-acetylneuraminate metabolic process (GO:0006054)4.71983726
5mitotic sister chromatid cohesion (GO:0007064)4.67818576
6centriole assembly (GO:0098534)4.43554585
7cytoplasmic mRNA processing body assembly (GO:0033962)4.36063712
8histone H3-K4 trimethylation (GO:0080182)4.32384827
9protoporphyrinogen IX biosynthetic process (GO:0006782)4.21768786
10negative regulation of cell killing (GO:0031342)4.13567681
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.13567681
12retrograde transport, vesicle recycling within Golgi (GO:0000301)4.13488349
13protein targeting to Golgi (GO:0000042)3.93287765
14establishment of protein localization to Golgi (GO:0072600)3.74272286
15histone H3-K4 methylation (GO:0051568)3.71469690
16nuclear pore complex assembly (GO:0051292)3.65956560
17microglial cell activation (GO:0001774)3.65395731
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.65179743
19regulation of DNA endoreduplication (GO:0032875)3.64819551
20regulation of RNA export from nucleus (GO:0046831)3.58299794
21DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.53352980
22peptidyl-lysine trimethylation (GO:0018023)3.48647743
23behavioral response to nicotine (GO:0035095)3.47945068
24purine deoxyribonucleotide catabolic process (GO:0009155)3.47733439
25protoporphyrinogen IX metabolic process (GO:0046501)3.39270195
26regulation of nucleobase-containing compound transport (GO:0032239)3.37086338
27glucocorticoid receptor signaling pathway (GO:0042921)3.36552562
28negative regulation of histone methylation (GO:0031061)3.30155163
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.26587746
30regulation of translation, ncRNA-mediated (GO:0045974)3.26587746
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.26587746
32neutrophil mediated immunity (GO:0002446)3.25160348
33regulation of establishment or maintenance of cell polarity (GO:0032878)3.25006477
34positive regulation of granulocyte differentiation (GO:0030854)3.21214529
35histone lysine methylation (GO:0034968)3.21062984
36regulation of hippo signaling (GO:0035330)3.19875773
37pre-miRNA processing (GO:0031054)3.19177231
38histone H3-K9 demethylation (GO:0033169)3.18345554
39base-excision repair, AP site formation (GO:0006285)3.17806284
40positive regulation of gamma-delta T cell activation (GO:0046645)3.15111242
41histone H3-K36 demethylation (GO:0070544)3.12736630
42regulation of gamma-delta T cell differentiation (GO:0045586)3.08782359
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07462639
44early endosome to late endosome transport (GO:0045022)3.06298932
45reciprocal DNA recombination (GO:0035825)3.05472335
46reciprocal meiotic recombination (GO:0007131)3.05472335
47response to folic acid (GO:0051593)3.04151654
48monoubiquitinated protein deubiquitination (GO:0035520)3.04146090
49* positive regulation of histone deacetylation (GO:0031065)3.02270886
50* positive regulation of protein deacetylation (GO:0090312)3.00061530
51DNA damage response, signal transduction resulting in transcription (GO:0042772)2.98681531
52positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.98543892
53regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.98543892
54nuclear pore organization (GO:0006999)2.97156758
55positive T cell selection (GO:0043368)2.90779777
56corticosteroid receptor signaling pathway (GO:0031958)2.85976829
57regulation of establishment of cell polarity (GO:2000114)2.85783834
58killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.84799633
59disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.84799633
60peptidyl-lysine methylation (GO:0018022)2.84252472
61positive regulation of erythrocyte differentiation (GO:0045648)2.83196656
62stress granule assembly (GO:0034063)2.81154454
63regulation of histone H3-K4 methylation (GO:0051569)2.80411894
64positive regulation of gene expression, epigenetic (GO:0045815)2.76997492
65peptidyl-threonine phosphorylation (GO:0018107)2.76475725
66regulation of gamma-delta T cell activation (GO:0046643)2.75018345
67regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.71814368
68positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.71814368
69coronary vasculature morphogenesis (GO:0060977)2.71678890
70rRNA catabolic process (GO:0016075)2.71424943
71peptidyl-threonine modification (GO:0018210)2.70205958
72insulin-like growth factor receptor signaling pathway (GO:0048009)2.70138554
73centrosome duplication (GO:0051298)2.69974250
74response to misfolded protein (GO:0051788)2.69827760
75T cell selection (GO:0045058)2.68096522
76fucose catabolic process (GO:0019317)2.66572508
77L-fucose metabolic process (GO:0042354)2.66572508
78L-fucose catabolic process (GO:0042355)2.66572508
79regulation of histone H3-K9 methylation (GO:0051570)2.65199103
80negative T cell selection (GO:0043383)2.62388137
81positive regulation of mRNA catabolic process (GO:0061014)2.62006939
82protein K48-linked deubiquitination (GO:0071108)2.61096588
83thymic T cell selection (GO:0045061)2.60915746
84interkinetic nuclear migration (GO:0022027)2.59827074
85histone methylation (GO:0016571)2.59808809
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59509571
87microtubule anchoring (GO:0034453)2.58971118
88regulation of mRNA catabolic process (GO:0061013)2.57746299
89pore complex assembly (GO:0046931)2.57585121
90regulation of histone methylation (GO:0031060)2.57248473
91peptidyl-lysine dimethylation (GO:0018027)2.57067346
92positive thymic T cell selection (GO:0045059)2.56962354
93microtubule organizing center organization (GO:0031023)2.56934383
94NLS-bearing protein import into nucleus (GO:0006607)2.56392086
95myeloid leukocyte mediated immunity (GO:0002444)2.56383869
96reactive oxygen species biosynthetic process (GO:1903409)2.55400149
97histone lysine demethylation (GO:0070076)2.55174479
98definitive hemopoiesis (GO:0060216)2.54484136
99regulation of pigment cell differentiation (GO:0050932)2.53505967
100DNA alkylation (GO:0006305)2.53445202
101DNA methylation (GO:0006306)2.53445202
102regulation of telomere maintenance (GO:0032204)2.53441204
103regulation of ARF protein signal transduction (GO:0032012)2.52665953
104vesicle transport along microtubule (GO:0047496)2.52432853
105histone H4-K16 acetylation (GO:0043984)2.51240687
106mRNA splice site selection (GO:0006376)2.49541088
107negative thymic T cell selection (GO:0045060)2.49106738
108embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48037784
109embryonic camera-type eye morphogenesis (GO:0048596)2.48013627
110DNA topological change (GO:0006265)2.47629320
111alkaloid metabolic process (GO:0009820)2.47246713
112angiotensin maturation (GO:0002003)2.46875594
113protein targeting to vacuole (GO:0006623)2.46330084
114protein targeting to lysosome (GO:0006622)2.46330084
115establishment of protein localization to vacuole (GO:0072666)2.46330084
116V(D)J recombination (GO:0033151)2.44910722
117histone H3-K9 methylation (GO:0051567)2.44760103
118regulation of histone H3-K27 methylation (GO:0061085)2.43683433
119cerebellar Purkinje cell differentiation (GO:0021702)2.43401804
120somatic diversification of immunoglobulins (GO:0016445)2.42714945
121DNA modification (GO:0006304)2.41104062
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.40172808
123positive regulation of developmental pigmentation (GO:0048087)2.40103305
124seminiferous tubule development (GO:0072520)2.39743466
125positive regulation of chemokine biosynthetic process (GO:0045080)2.39270545
126histone demethylation (GO:0016577)2.38366030
127modulation of growth of symbiont involved in interaction with host (GO:0044144)2.37906142
128regulation of growth of symbiont in host (GO:0044126)2.37906142
129negative regulation of growth of symbiont in host (GO:0044130)2.37906142
130negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.37906142
131histone H3-K9 modification (GO:0061647)2.37872410
132pyrimidine dimer repair (GO:0006290)2.37312914
133neural tube formation (GO:0001841)2.36638251
134regulation of mitotic spindle organization (GO:0060236)2.36598866
135regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36478725
136positive regulation of histone H3-K4 methylation (GO:0051571)2.35479317
137negative regulation of histone acetylation (GO:0035067)2.35229063
138ventricular system development (GO:0021591)2.34790046
139locomotory exploration behavior (GO:0035641)2.34580181
140positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.32262134
141cellular response to exogenous dsRNA (GO:0071360)2.30904360
142positive regulation of DNA-templated transcription, initiation (GO:2000144)2.30729626
143nerve growth factor signaling pathway (GO:0038180)2.30678268
144centrosome organization (GO:0051297)2.29943935
145DNA methylation or demethylation (GO:0044728)2.29919262
146RNA stabilization (GO:0043489)2.28759917
147mRNA stabilization (GO:0048255)2.28759917
148antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.27370347
149response to interleukin-15 (GO:0070672)2.26329796
150regulation of ARF GTPase activity (GO:0032312)2.23449603
151embryonic hemopoiesis (GO:0035162)2.23130886
152interferon-gamma production (GO:0032609)2.23059234
153regulation of clathrin-mediated endocytosis (GO:2000369)2.23039919
154nucleus localization (GO:0051647)2.22823620
155establishment of nucleus localization (GO:0040023)2.20947736
156positive regulation of Rap GTPase activity (GO:0032854)2.20767873
157growth hormone receptor signaling pathway (GO:0060396)2.19934435
158positive regulation of RNA splicing (GO:0033120)2.19155500
159regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.17360953
160phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.17165055
161negative regulation of histone modification (GO:0031057)2.16791762
162phosphatidylinositol phosphorylation (GO:0046854)2.16629182
163sister chromatid cohesion (GO:0007062)2.16197260
164megakaryocyte development (GO:0035855)2.16195413
165protein dealkylation (GO:0008214)2.13781354
166protein demethylation (GO:0006482)2.13781354
167mitotic chromosome condensation (GO:0007076)2.12034498
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.10477132
169positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.09176883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.97707184
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.85238660
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.79675781
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40570213
5IGF1R_20145208_ChIP-Seq_DFB_Human3.40118955
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06978362
7GBX2_23144817_ChIP-Seq_PC3_Human2.95258129
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.88392556
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58450065
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33384368
11ZNF274_21170338_ChIP-Seq_K562_Hela2.27955680
12MYC_22102868_ChIP-Seq_BL_Human2.25017194
13TCF7_22412390_ChIP-Seq_EML_Mouse2.19342912
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16323252
15RUNX_20019798_ChIP-Seq_JUKART_Human2.16246567
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.11960323
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06345589
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99636939
19ER_23166858_ChIP-Seq_MCF-7_Human1.97493733
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97168821
21KDM2B_26808549_Chip-Seq_DND41_Human1.88439037
22TAF15_26573619_Chip-Seq_HEK293_Human1.88095682
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.86885319
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86633127
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85644137
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84999607
27SCL_19346495_ChIP-Seq_HPC-7_Human1.82189254
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.79742089
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.78292228
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77952828
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75588960
32VDR_22108803_ChIP-Seq_LS180_Human1.74620401
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73206484
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.71758613
35TP53_16413492_ChIP-PET_HCT116_Human1.71219555
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70128578
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70117094
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69601977
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.68060648
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67129276
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66314387
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65375661
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61953948
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59082347
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58376637
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57266653
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.56416809
48* DROSHA_22980978_ChIP-Seq_HELA_Human1.56297741
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54245528
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.53163476
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.53113562
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53097050
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.49501136
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49182024
55* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48788284
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47982122
57* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45821516
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42851973
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42150801
60EZH2_22144423_ChIP-Seq_EOC_Human1.41413920
61BCAT_22108803_ChIP-Seq_LS180_Human1.38146587
62RXR_22108803_ChIP-Seq_LS180_Human1.36934269
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36468536
64EWS_26573619_Chip-Seq_HEK293_Human1.34710059
65* FLI1_21867929_ChIP-Seq_TH2_Mouse1.34053634
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32903495
67SPI1_23127762_ChIP-Seq_K562_Human1.32676683
68GATA1_22025678_ChIP-Seq_K562_Human1.31731271
69MYB_26560356_Chip-Seq_TH2_Human1.31472930
70UTX_26944678_Chip-Seq_JUKART_Human1.29875638
71P300_19829295_ChIP-Seq_ESCs_Human1.29823727
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.29256487
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.29178695
74MYB_26560356_Chip-Seq_TH1_Human1.29022399
75AHR_22903824_ChIP-Seq_MCF-7_Human1.27895042
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25803200
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25724210
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.25679118
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24161651
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24026697
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.23762905
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.23691661
83MAF_26560356_Chip-Seq_TH1_Human1.23150606
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23038505
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22800401
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.21662169
87FUS_26573619_Chip-Seq_HEK293_Human1.21441240
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.21209679
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20642598
90VDR_21846776_ChIP-Seq_THP-1_Human1.20256732
91KDM2B_26808549_Chip-Seq_K562_Human1.19818934
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19791773
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19291735
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17884533
95CBP_20019798_ChIP-Seq_JUKART_Human1.17884533
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17518111
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16065536
98* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15783927
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15301599
100* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14760282
101* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14542591
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13919681
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13691118
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13528502
105GATA1_19941826_ChIP-Seq_K562_Human1.13366358
106* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12917751
107WDR5_24793694_ChIP-Seq_LNCAP_Human1.12694727
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12356219
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12039885
110IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10707925
111RUNX2_22187159_ChIP-Seq_PCA_Human1.10696677
112AR_25329375_ChIP-Seq_VCAP_Human1.10690006
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10584639
114* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09778548
115STAT3_23295773_ChIP-Seq_U87_Human1.05773777
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04890679
117TCF4_22108803_ChIP-Seq_LS180_Human1.04252595
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04136597
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03815959
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.03596544
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02769830
122TP53_22573176_ChIP-Seq_HFKS_Human1.01992071
123AR_19668381_ChIP-Seq_PC3_Human1.01128508
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01101965
125SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00348183
126TCF4_23295773_ChIP-Seq_U87_Human0.99210040
127ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99002065
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.98967019
129AR_21572438_ChIP-Seq_LNCaP_Human0.98783736
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98183175
131CIITA_25753668_ChIP-Seq_RAJI_Human0.97962125
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97651111
133REST_21632747_ChIP-Seq_MESCs_Mouse0.97609239
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.96351194
135* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.95710503
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.95070842
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94991704
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94988280
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94688014
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.94338169
141SMAD4_21799915_ChIP-Seq_A2780_Human0.93776036
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93770519
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93403852
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93292494
145VDR_24763502_ChIP-Seq_THP-1_Human0.93025175
146E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92680254
147GATA3_27048872_Chip-Seq_THYMUS_Human0.92448162
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91653470
149* IRF1_19129219_ChIP-ChIP_H3396_Human0.91447309
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.90122966
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89759580
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89684069
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89574042
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89156524
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88696660
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88696660
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87863756
158* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87353217
159NCOR1_26117541_ChIP-Seq_K562_Human0.87061325
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86647813
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85818485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract6.49371795
2MP0000569_abnormal_digit_pigmentation4.91288655
3MP0003300_gastrointestinal_ulcer3.51278419
4MP0004043_abnormal_pH_regulation3.48500523
5MP0003787_abnormal_imprinting3.43346096
6MP0002009_preneoplasia3.00598909
7MP0010234_abnormal_vibrissa_follicle2.92167949
8MP0009780_abnormal_chondrocyte_physiolo2.80277264
9MP0008058_abnormal_DNA_repair2.79536267
10MP0005076_abnormal_cell_differentiation2.74668430
11MP0002166_altered_tumor_susceptibility2.60191639
12MP0010352_gastrointestinal_tract_polyps2.49805929
13MP0003045_fibrosis2.40904949
14MP0002877_abnormal_melanocyte_morpholog2.28898758
15MP0002396_abnormal_hematopoietic_system2.28291605
16MP0005365_abnormal_bile_salt2.19097674
17MP0004808_abnormal_hematopoietic_stem2.11305804
18MP0002006_tumorigenesis2.09388099
19MP0005174_abnormal_tail_pigmentation2.01567799
20MP0004859_abnormal_synaptic_plasticity1.96118710
21MP0003763_abnormal_thymus_physiology1.88919884
22MP0009278_abnormal_bone_marrow1.82834939
23MP0003303_peritoneal_inflammation1.79545445
24MP0003646_muscle_fatigue1.77911279
25* MP0000703_abnormal_thymus_morphology1.73729189
26MP0004185_abnormal_adipocyte_glucose1.71728931
27MP0002928_abnormal_bile_duct1.70111020
28MP0003183_abnormal_peptide_metabolism1.61924960
29MP0005085_abnormal_gallbladder_physiolo1.53681284
30MP0004264_abnormal_extraembryonic_tissu1.51869396
31MP0005666_abnormal_adipose_tissue1.49815760
32MP0005409_darkened_coat_color1.48643521
33MP0003121_genomic_imprinting1.47417661
34MP0010307_abnormal_tumor_latency1.46458849
35MP0004145_abnormal_muscle_electrophysio1.44254135
36MP0005310_abnormal_salivary_gland1.41102492
37MP0008872_abnormal_physiological_respon1.40481358
38* MP0008961_abnormal_basal_metabolism1.39675653
39MP0009703_decreased_birth_body1.37083709
40MP0008057_abnormal_DNA_replication1.37014539
41MP0005551_abnormal_eye_electrophysiolog1.35980827
42MP0010678_abnormal_skin_adnexa1.31902469
43* MP0002398_abnormal_bone_marrow1.25238827
44MP0004130_abnormal_muscle_cell1.25004697
45MP0003866_abnormal_defecation1.23063575
46MP0002127_abnormal_cardiovascular_syste1.21239525
47MP0003195_calcinosis1.20215060
48MP0004885_abnormal_endolymph1.19413511
49MP0009046_muscle_twitch1.17456370
50MP0005645_abnormal_hypothalamus_physiol1.16488361
51MP0001501_abnormal_sleep_pattern1.15933207
52* MP0005375_adipose_tissue_phenotype1.15660666
53MP0002086_abnormal_extraembryonic_tissu1.14839469
54MP0004197_abnormal_fetal_growth/weight/1.13016721
55MP0002925_abnormal_cardiovascular_devel1.12665439
56MP0004924_abnormal_behavior1.12300121
57MP0005386_behavior/neurological_phenoty1.12300121
58MP0002735_abnormal_chemical_nociception1.11942404
59MP0004742_abnormal_vestibular_system1.11891990
60MP0008877_abnormal_DNA_methylation1.10993626
61MP0003943_abnormal_hepatobiliary_system1.10619342
62MP0006276_abnormal_autonomic_nervous1.10384558
63MP0002084_abnormal_developmental_patter1.10335817
64MP0003705_abnormal_hypodermis_morpholog1.07499363
65MP0005167_abnormal_blood-brain_barrier1.07172242
66MP0005187_abnormal_penis_morphology1.06129233
67MP0002909_abnormal_adrenal_gland1.05545148
68MP0000383_abnormal_hair_follicle1.03841217
69MP0010094_abnormal_chromosome_stability1.03451277
70MP0004142_abnormal_muscle_tone1.02878446
71MP0001873_stomach_inflammation1.02749483
72MP0003091_abnormal_cell_migration1.01998429
73MP0000733_abnormal_muscle_development0.99922014
74MP0005266_abnormal_metabolism0.99855203
75MP0002876_abnormal_thyroid_physiology0.99850113
76MP0001800_abnormal_humoral_immune0.98749307
77* MP0009115_abnormal_fat_cell0.98409232
78MP0010630_abnormal_cardiac_muscle0.97898895
79MP0003935_abnormal_craniofacial_develop0.97698846
80MP0003111_abnormal_nucleus_morphology0.94770016
81MP0002067_abnormal_sensory_capabilities0.92421337
82MP0010155_abnormal_intestine_physiology0.92354754
83MP0008770_decreased_survivor_rate0.92315045
84MP0003984_embryonic_growth_retardation0.92272060
85MP0002088_abnormal_embryonic_growth/wei0.92255684
86MP0006292_abnormal_olfactory_placode0.91868515
87MP0005670_abnormal_white_adipose0.90621550
88MP0003828_pulmonary_edema0.90093775
89* MP0001784_abnormal_fluid_regulation0.89154633
90MP0003890_abnormal_embryonic-extraembry0.89078716
91MP0000371_diluted_coat_color0.88972489
92MP0008569_lethality_at_weaning0.88792403
93MP0008775_abnormal_heart_ventricle0.87166034
94MP0003252_abnormal_bile_duct0.87139524
95MP0004134_abnormal_chest_morphology0.85831848
96* MP0002722_abnormal_immune_system0.85784913
97MP0000516_abnormal_urinary_system0.85663366
98MP0005367_renal/urinary_system_phenotyp0.85663366
99MP0005671_abnormal_response_to0.84892730
100MP0000631_abnormal_neuroendocrine_gland0.84192537
101MP0000230_abnormal_systemic_arterial0.83916207
102MP0001944_abnormal_pancreas_morphology0.83068341
103MP0002572_abnormal_emotion/affect_behav0.82364147
104MP0009672_abnormal_birth_weight0.81778951
105MP0002095_abnormal_skin_pigmentation0.81762547
106* MP0000003_abnormal_adipose_tissue0.81246941
107MP0001545_abnormal_hematopoietic_system0.81128268
108MP0005397_hematopoietic_system_phenotyp0.81128268
109MP0001672_abnormal_embryogenesis/_devel0.81006381
110MP0005380_embryogenesis_phenotype0.81006381
111MP0010368_abnormal_lymphatic_system0.80657962
112MP0003635_abnormal_synaptic_transmissio0.79362219
113* MP0000716_abnormal_immune_system0.79141763
114MP0002272_abnormal_nervous_system0.77977024
115MP0000266_abnormal_heart_morphology0.77812658
116MP0000778_abnormal_nervous_system0.77552998
117MP0004084_abnormal_cardiac_muscle0.77071386
118MP0000465_gastrointestinal_hemorrhage0.76129373
119MP0001879_abnormal_lymphatic_vessel0.75940534
120MP0002063_abnormal_learning/memory/cond0.75656067
121MP0002557_abnormal_social/conspecific_i0.75355541
122MP0002971_abnormal_brown_adipose0.74858787
123MP0001986_abnormal_taste_sensitivity0.74705652
124MP0005075_abnormal_melanosome_morpholog0.74154375
125MP0005084_abnormal_gallbladder_morpholo0.74054652
126MP0003567_abnormal_fetal_cardiomyocyte0.73259088
127MP0001188_hyperpigmentation0.72835230
128MP0003698_abnormal_male_reproductive0.72737578
129MP0006072_abnormal_retinal_apoptosis0.72428293
130MP0005646_abnormal_pituitary_gland0.72285943
131MP0004510_myositis0.71967397
132MP0002420_abnormal_adaptive_immunity0.71742433
133MP0009697_abnormal_copulation0.71341330
134MP0002075_abnormal_coat/hair_pigmentati0.71204897
135MP0002085_abnormal_embryonic_tissue0.71036624
136MP0000955_abnormal_spinal_cord0.70829791
137MP0000428_abnormal_craniofacial_morphol0.70340041
138MP0000432_abnormal_head_morphology0.69451521
139MP0000427_abnormal_hair_cycle0.69208391
140MP0001819_abnormal_immune_cell0.68686540
141MP0005248_abnormal_Harderian_gland0.68164522
142MP0000490_abnormal_crypts_of0.67889157
143MP0001486_abnormal_startle_reflex0.67223155
144MP0001790_abnormal_immune_system0.67057132
145MP0005387_immune_system_phenotype0.67057132
146MP0003566_abnormal_cell_adhesion0.66431716
147MP0000015_abnormal_ear_pigmentation0.66239728
148MP0006138_congestive_heart_failure0.66009259
149MP0002638_abnormal_pupillary_reflex0.65949897
150MP0004036_abnormal_muscle_relaxation0.65586651
151MP0008995_early_reproductive_senescence0.65399757
152* MP0002970_abnormal_white_adipose0.65251676
153MP0003868_abnormal_feces_composition0.64960677
154MP0004947_skin_inflammation0.64840879
155MP0002184_abnormal_innervation0.63025702
156MP0002064_seizures0.59062638
157MP0009745_abnormal_behavioral_response0.56609406
158MP0002229_neurodegeneration0.56561430
159MP0005253_abnormal_eye_physiology0.56212020
160MP0003959_abnormal_lean_body0.54506493
161MP0000689_abnormal_spleen_morphology0.54462966

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.11194711
2Protruding tongue (HP:0010808)4.46286835
3Abnormality of the fingertips (HP:0001211)4.44332849
4Hyperventilation (HP:0002883)4.14817585
5Abnormality of the renal cortex (HP:0011035)3.68094726
6Macroorchidism (HP:0000053)3.58515113
7Progressive cerebellar ataxia (HP:0002073)3.50570406
8Fair hair (HP:0002286)3.39193766
9Clumsiness (HP:0002312)3.34758442
10Abnormality of the prostate (HP:0008775)3.20847066
11Absent speech (HP:0001344)3.14832874
12Failure to thrive in infancy (HP:0001531)3.03196789
13Tubulointerstitial nephritis (HP:0001970)3.02850804
14Abnormality of the renal medulla (HP:0100957)2.96551642
15Hyperacusis (HP:0010780)2.83088240
16Generalized hypopigmentation of hair (HP:0011358)2.81067753
17Metabolic alkalosis (HP:0200114)2.80610735
18Obsessive-compulsive behavior (HP:0000722)2.78103524
19Broad-based gait (HP:0002136)2.76466262
20Gaze-evoked nystagmus (HP:0000640)2.76245040
21Long eyelashes (HP:0000527)2.72712614
22Tubular atrophy (HP:0000092)2.71841933
23Hyperkalemia (HP:0002153)2.71760469
24Chromsome breakage (HP:0040012)2.70761181
25Truncal obesity (HP:0001956)2.67833273
26Urethral obstruction (HP:0000796)2.63680436
27Partial agenesis of the corpus callosum (HP:0001338)2.63347407
28Febrile seizures (HP:0002373)2.61108793
29Nephronophthisis (HP:0000090)2.59534488
30Genetic anticipation (HP:0003743)2.59425239
31Narrow palate (HP:0000189)2.54785401
32Lissencephaly (HP:0001339)2.54060564
33Renal cortical cysts (HP:0000803)2.53584895
34Ureteral obstruction (HP:0006000)2.45792294
35Heterotopia (HP:0002282)2.45264439
36Ureteral stenosis (HP:0000071)2.44030316
37Prostate neoplasm (HP:0100787)2.43896743
38Cerebral aneurysm (HP:0004944)2.41803351
39Supernumerary ribs (HP:0005815)2.40807785
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40199661
41Short 4th metacarpal (HP:0010044)2.40199661
42Widely spaced teeth (HP:0000687)2.39330083
43Increased nuchal translucency (HP:0010880)2.39127802
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.38299003
45Anal stenosis (HP:0002025)2.34662294
46Absent frontal sinuses (HP:0002688)2.33809567
47Molar tooth sign on MRI (HP:0002419)2.32460454
48Abnormality of midbrain morphology (HP:0002418)2.32460454
49T lymphocytopenia (HP:0005403)2.31382529
50Subacute progressive viral hepatitis (HP:0006572)2.27227132
51Elfin facies (HP:0004428)2.26193489
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25902107
53Dysmetric saccades (HP:0000641)2.24157587
54Impulsivity (HP:0100710)2.23291152
55Neonatal hypoglycemia (HP:0001998)2.19839721
56Tubulointerstitial abnormality (HP:0001969)2.18929196
57Type II lissencephaly (HP:0007260)2.18288236
58Neoplasm of the oral cavity (HP:0100649)2.17393952
59Pachygyria (HP:0001302)2.17059654
60Clubbing of toes (HP:0100760)2.16930302
61Abnormality of chloride homeostasis (HP:0011422)2.15309915
62Panhypogammaglobulinemia (HP:0003139)2.14752457
63Transitional cell carcinoma of the bladder (HP:0006740)2.13229560
64Blue irides (HP:0000635)2.11834324
65Ankyloglossia (HP:0010296)2.11356787
66Supernumerary bones of the axial skeleton (HP:0009144)2.11132053
67Prominent nose (HP:0000448)2.10750677
68Congenital stationary night blindness (HP:0007642)2.10142942
69Abnormality of incisor morphology (HP:0011063)2.07419668
70Trigonocephaly (HP:0000243)2.07251153
71Thyroiditis (HP:0100646)2.05724144
72Pancreatic cysts (HP:0001737)2.05220358
73Abnormality of male internal genitalia (HP:0000022)2.04194490
74Stomach cancer (HP:0012126)2.03136392
75Lip pit (HP:0100267)2.03120171
76Abnormality of oral frenula (HP:0000190)2.02687019
77Abnormal hair whorl (HP:0010721)2.02411433
78Abnormality of the nasal septum (HP:0000419)2.01520710
79Thick eyebrow (HP:0000574)2.01408630
80Viral hepatitis (HP:0006562)1.99604987
81Tented upper lip vermilion (HP:0010804)1.99154846
82Patellar aplasia (HP:0006443)1.98991229
83Tapered finger (HP:0001182)1.98650886
84Abnormality of T cell number (HP:0011839)1.98636570
85Smooth philtrum (HP:0000319)1.97997540
86Medial flaring of the eyebrow (HP:0010747)1.97184615
87Renovascular hypertension (HP:0100817)1.97136937
88Recurrent viral infections (HP:0004429)1.96193378
89Abnormality of potassium homeostasis (HP:0011042)1.95297846
90Papilledema (HP:0001085)1.95245445
91Abnormality of the astrocytes (HP:0100707)1.93651936
92Astrocytoma (HP:0009592)1.93651936
93Exotropia (HP:0000577)1.91909260
94Bladder carcinoma (HP:0002862)1.91829569
95Bladder neoplasm (HP:0009725)1.91829569
96Acute lymphatic leukemia (HP:0006721)1.91431648
97Malignant gastrointestinal tract tumors (HP:0006749)1.90789342
98Gastrointestinal carcinoma (HP:0002672)1.90789342
99Acute myeloid leukemia (HP:0004808)1.89998698
100Hypochromic microcytic anemia (HP:0004840)1.89721771
101Deep philtrum (HP:0002002)1.88961801
102Biliary tract neoplasm (HP:0100574)1.87472264
103Abnormality of DNA repair (HP:0003254)1.87409276
104Chest pain (HP:0100749)1.87252567
105Severe combined immunodeficiency (HP:0004430)1.87178627
106Vertebral arch anomaly (HP:0008438)1.87100634
107Cutis marmorata (HP:0000965)1.86514498
108Chronic hepatic failure (HP:0100626)1.86313281
109Impaired smooth pursuit (HP:0007772)1.85685996
110Hypoplastic iliac wings (HP:0002866)1.84396066
111Proximal placement of thumb (HP:0009623)1.83293808
112Bowel diverticulosis (HP:0005222)1.82995018
113Decreased circulating renin level (HP:0003351)1.82987145
114Glioma (HP:0009733)1.82928868
115Inappropriate behavior (HP:0000719)1.82089267
116Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82033521
117Hypokalemic alkalosis (HP:0001949)1.81346827
118Intellectual disability, severe (HP:0010864)1.81166650
119Rectal prolapse (HP:0002035)1.80316352
120Sandal gap (HP:0001852)1.80248025
121Leiomyosarcoma (HP:0100243)1.79309855
122Uterine leiomyosarcoma (HP:0002891)1.79309855
123Macroglossia (HP:0000158)1.78748961
124Progressive microcephaly (HP:0000253)1.77654751
125Sporadic (HP:0003745)1.77597830
126B lymphocytopenia (HP:0010976)1.76779878
127Abnormality of B cell number (HP:0010975)1.76779878
128Cystic liver disease (HP:0006706)1.76307841
129Deviation of the thumb (HP:0009603)1.75923146
130Ectopic kidney (HP:0000086)1.75600198
131Low anterior hairline (HP:0000294)1.74957727
132Aplasia/Hypoplasia of the patella (HP:0006498)1.74646117
133Overriding aorta (HP:0002623)1.74471367
134Poor coordination (HP:0002370)1.73790700
135Hepatoblastoma (HP:0002884)1.73145593
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72811251
137Ependymoma (HP:0002888)1.72627583
138Bilateral microphthalmos (HP:0007633)1.72463394
139Pointed chin (HP:0000307)1.72287861
140Insomnia (HP:0100785)1.71848480
141Hypoplastic ischia (HP:0003175)1.71114670
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.71088952
143Polyuria (HP:0000103)1.70656216
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.70303536
145Epidermoid cyst (HP:0200040)1.70187066
146Broad palm (HP:0001169)1.69958942
147Abnormality of the 4th metacarpal (HP:0010012)1.69343373
148Pancreatic fibrosis (HP:0100732)1.68932588
149Papillary thyroid carcinoma (HP:0002895)1.68123478
150Medulloblastoma (HP:0002885)1.67400581
151Abnormality of ocular smooth pursuit (HP:0000617)1.66992140
152Flat face (HP:0012368)1.66845858
153Open mouth (HP:0000194)1.66665869
154Congenital hepatic fibrosis (HP:0002612)1.66654897
155Increased number of teeth (HP:0011069)1.66596031
156Enlarged kidneys (HP:0000105)1.66322587
157Attention deficit hyperactivity disorder (HP:0007018)1.65870499
158Bulbous nose (HP:0000414)1.65866319
159Abnormality of chromosome stability (HP:0003220)1.65695088
160Agammaglobulinemia (HP:0004432)1.65556465
161Aqueductal stenosis (HP:0002410)1.62881401
162Cutaneous photosensitivity (HP:0000992)1.62678325
163IgM deficiency (HP:0002850)1.62265505
164Neoplasm of the adrenal cortex (HP:0100641)1.59786413
165Sacral dimple (HP:0000960)1.59605068
166Urinary bladder sphincter dysfunction (HP:0002839)1.58851890
167Drooling (HP:0002307)1.58851341
168Excessive salivation (HP:0003781)1.58851341
169Colitis (HP:0002583)1.57905242
170Hemiplegia (HP:0002301)1.57824093
171Abnormality of the gastric mucosa (HP:0004295)1.57685876
172Renal duplication (HP:0000075)1.57521532
173Enlarged penis (HP:0000040)1.57148815
174Skull defect (HP:0001362)1.57018119
175Scanning speech (HP:0002168)1.56869225
176Aortic aneurysm (HP:0004942)1.56384629
177Colon cancer (HP:0003003)1.55701715
178Aneurysm (HP:0002617)1.55401451
179Progressive hearing impairment (HP:0001730)1.54656013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.24436562
2CDK124.07656435
3CAMK1G2.93659984
4CAMKK22.89052173
5CAMK1D2.51150261
6BRD42.49294788
7EEF2K2.41838317
8BMPR1B2.29970776
9SIK22.04011511
10DMPK2.02510344
11FGFR31.97468634
12MAP3K101.94422771
13WNK41.78155758
14TAOK31.77978959
15AKT31.71608485
16PKN21.66946720
17TAF11.64402240
18FGFR21.62369080
19FRK1.59279536
20RIPK11.58353349
21MAP3K71.54196731
22PTK61.52515250
23ACVR1B1.51820976
24MAP4K11.49772473
25NUAK11.49505599
26ITK1.48441706
27ERN11.45778871
28CDK91.42956302
29CDK61.41715718
30HIPK21.39740518
31PDGFRB1.38697436
32LATS11.37317214
33TRIB31.37158191
34PDGFRA1.33562542
35PNCK1.32666181
36SGK31.32339124
37ALK1.31057967
38GRK11.24648652
39PIK3CG1.22167834
40MTOR1.18921627
41MARK21.17102584
42PRKCH1.14956762
43TXK1.14192191
44TIE11.14059967
45CDC71.09823254
46GRK61.09638691
47MAPK131.08885087
48INSRR1.07505170
49STK111.05040354
50FGFR41.04990694
51JAK11.02411906
52NTRK31.01301221
53SIK11.00845367
54PIK3CA1.00328667
55SYK0.99252394
56MARK10.96618041
57WNK10.95917925
58RET0.94053778
59MAP4K20.91729005
60STK100.89331449
61PRKD20.88302644
62TAOK10.87196551
63STK390.87159236
64CDK40.84642108
65JAK30.84380852
66PAK30.84319611
67ICK0.83475848
68CDC42BPA0.83466091
69HCK0.82610910
70SGK20.81876998
71SGK4940.81675566
72SGK2230.81675566
73CLK10.80916055
74MELK0.79411800
75IKBKE0.78912351
76TYRO30.78768663
77DYRK1A0.78074261
78MAP3K20.77791151
79SGK10.75004779
80TNIK0.73476933
81ADRBK20.71717845
82EPHB10.71500264
83RIPK40.70838402
84SCYL20.69927825
85FES0.69300329
86ATM0.69214743
87TEC0.68242980
88TRPM70.67687964
89CSNK1D0.65969670
90FGFR10.65847495
91OBSCN0.65784003
92KIT0.65315812
93CAMK40.64291703
94TNK20.63864819
95EPHA30.63713950
96STK40.63121733
97NTRK20.63101999
98PTK2B0.62615314
99ATR0.62396249
100TTN0.61801004
101PRKAA20.61581846
102CHEK10.60861980
103PRKCQ0.60857629
104WNK30.60777432
105PRKDC0.60390326
106CAMKK10.59186138
107PRKAA10.58793352
108BTK0.58556776
109PINK10.58080368
110LCK0.58042049
111NEK20.57758673
112* MAPK140.57476678
113CSK0.56992118
114MAP3K40.56815945
115STK380.56335251
116PRKD30.55555526
117JAK20.55224079
118RPS6KB10.54899836
119MAPK100.54868378
120FER0.54449430
121STK30.54055156
122MAPKAPK50.53282327
123MAPK110.53234745
124VRK20.52313452
125ERBB20.52212893
126RPS6KB20.51689290
127NLK0.51424312
128CAMK10.51382990
129* GSK3B0.51303930
130PASK0.50721869
131CSNK1A1L0.50616426
132RPS6KA30.50350798
133OXSR10.50310176
134SMG10.50297874
135PAK20.48904899
136* CDK20.48713500
137PRKD10.48395534
138MKNK20.47949873
139FYN0.45760997
140MAP2K70.42954245
141PIM10.42820612
142GRK50.40927957
143TLK10.39559639
144DAPK20.36405235
145CSNK1E0.35398660
146CDK80.30867389

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046142.58436891
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07693033
3Linoleic acid metabolism_Homo sapiens_hsa005912.02591580
4Phototransduction_Homo sapiens_hsa047441.86163284
5Lysine degradation_Homo sapiens_hsa003101.80696544
6Fanconi anemia pathway_Homo sapiens_hsa034601.75348757
7Nitrogen metabolism_Homo sapiens_hsa009101.71977823
8Type II diabetes mellitus_Homo sapiens_hsa049301.71449235
9Histidine metabolism_Homo sapiens_hsa003401.67919500
10Long-term potentiation_Homo sapiens_hsa047201.64019932
11Caffeine metabolism_Homo sapiens_hsa002321.60455373
12Chronic myeloid leukemia_Homo sapiens_hsa052201.57266722
13T cell receptor signaling pathway_Homo sapiens_hsa046601.54581213
14B cell receptor signaling pathway_Homo sapiens_hsa046621.50002204
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48826079
16Taste transduction_Homo sapiens_hsa047421.45403211
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44306563
18Primary immunodeficiency_Homo sapiens_hsa053401.42352457
19Dorso-ventral axis formation_Homo sapiens_hsa043201.40884420
20Ether lipid metabolism_Homo sapiens_hsa005651.40240306
21Glioma_Homo sapiens_hsa052141.36285138
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.34727753
23Endometrial cancer_Homo sapiens_hsa052131.34201299
24Ovarian steroidogenesis_Homo sapiens_hsa049131.33784302
25mTOR signaling pathway_Homo sapiens_hsa041501.32928946
26Non-small cell lung cancer_Homo sapiens_hsa052231.32822792
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30220152
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.29161712
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27183210
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26906450
31Acute myeloid leukemia_Homo sapiens_hsa052211.21996779
32MicroRNAs in cancer_Homo sapiens_hsa052061.21732963
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21462131
34* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21068532
35ABC transporters_Homo sapiens_hsa020101.19039696
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18733331
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18313357
38Estrogen signaling pathway_Homo sapiens_hsa049151.18106739
39Colorectal cancer_Homo sapiens_hsa052101.15714976
40ErbB signaling pathway_Homo sapiens_hsa040121.11440414
41Renin secretion_Homo sapiens_hsa049241.11415725
42Pancreatic cancer_Homo sapiens_hsa052121.11072837
43Basal transcription factors_Homo sapiens_hsa030221.09250345
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08973918
45Platelet activation_Homo sapiens_hsa046111.08583758
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.08424447
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.07919698
48Choline metabolism in cancer_Homo sapiens_hsa052311.07232426
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06745184
50Insulin secretion_Homo sapiens_hsa049111.06325544
51Salivary secretion_Homo sapiens_hsa049701.06214274
52Adherens junction_Homo sapiens_hsa045201.06171706
53Osteoclast differentiation_Homo sapiens_hsa043801.05307538
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.04873503
55Homologous recombination_Homo sapiens_hsa034401.04779043
56GnRH signaling pathway_Homo sapiens_hsa049121.04014213
57Insulin resistance_Homo sapiens_hsa049311.03927371
58Circadian entrainment_Homo sapiens_hsa047131.03781298
59Prostate cancer_Homo sapiens_hsa052151.03365991
60Gastric acid secretion_Homo sapiens_hsa049711.03356952
61Glutamatergic synapse_Homo sapiens_hsa047241.01880254
62Inositol phosphate metabolism_Homo sapiens_hsa005621.00588548
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99334122
64Glycerolipid metabolism_Homo sapiens_hsa005610.98381626
65Oxytocin signaling pathway_Homo sapiens_hsa049210.97685966
66Serotonergic synapse_Homo sapiens_hsa047260.97322154
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96958361
68Long-term depression_Homo sapiens_hsa047300.96856351
69FoxO signaling pathway_Homo sapiens_hsa040680.96650305
70cAMP signaling pathway_Homo sapiens_hsa040240.96401074
71Amphetamine addiction_Homo sapiens_hsa050310.96073852
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95343750
73Butanoate metabolism_Homo sapiens_hsa006500.95221150
74Prolactin signaling pathway_Homo sapiens_hsa049170.94854183
75VEGF signaling pathway_Homo sapiens_hsa043700.94437620
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94124203
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.93774174
78Base excision repair_Homo sapiens_hsa034100.92740062
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92201622
80* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92050480
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91621370
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91407781
83Cholinergic synapse_Homo sapiens_hsa047250.91261474
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89980548
85Proteoglycans in cancer_Homo sapiens_hsa052050.88922997
86Small cell lung cancer_Homo sapiens_hsa052220.88650731
87MAPK signaling pathway_Homo sapiens_hsa040100.88363329
88Chemokine signaling pathway_Homo sapiens_hsa040620.88344760
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.87316520
90mRNA surveillance pathway_Homo sapiens_hsa030150.87089641
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85691008
92Renal cell carcinoma_Homo sapiens_hsa052110.85150458
93Dopaminergic synapse_Homo sapiens_hsa047280.84643888
94Melanogenesis_Homo sapiens_hsa049160.84545820
95Insulin signaling pathway_Homo sapiens_hsa049100.84190770
96Focal adhesion_Homo sapiens_hsa045100.83583260
97Wnt signaling pathway_Homo sapiens_hsa043100.82643930
98Tryptophan metabolism_Homo sapiens_hsa003800.81435629
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81330337
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80075117
101Morphine addiction_Homo sapiens_hsa050320.80057405
102Circadian rhythm_Homo sapiens_hsa047100.79629221
103Asthma_Homo sapiens_hsa053100.79524643
104HTLV-I infection_Homo sapiens_hsa051660.77419567
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.76420014
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76336897
107AMPK signaling pathway_Homo sapiens_hsa041520.76308550
108Glucagon signaling pathway_Homo sapiens_hsa049220.76175647
109Notch signaling pathway_Homo sapiens_hsa043300.75689805
110Viral myocarditis_Homo sapiens_hsa054160.73250908
111Rap1 signaling pathway_Homo sapiens_hsa040150.73200636
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72586781
113Hepatitis B_Homo sapiens_hsa051610.72426284
114Pancreatic secretion_Homo sapiens_hsa049720.72109719
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70714833
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70706420
117Thyroid hormone synthesis_Homo sapiens_hsa049180.70068076
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.69060979
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68568180
120Gap junction_Homo sapiens_hsa045400.68395461
121Toxoplasmosis_Homo sapiens_hsa051450.68293255
122Axon guidance_Homo sapiens_hsa043600.67801884
123Thyroid cancer_Homo sapiens_hsa052160.67396530
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67144178
125Calcium signaling pathway_Homo sapiens_hsa040200.66462694
126Pathways in cancer_Homo sapiens_hsa052000.66439399
127Hematopoietic cell lineage_Homo sapiens_hsa046400.65948239
128Dilated cardiomyopathy_Homo sapiens_hsa054140.64605207
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64205826
130GABAergic synapse_Homo sapiens_hsa047270.63940166
131Nicotine addiction_Homo sapiens_hsa050330.63495648
132Olfactory transduction_Homo sapiens_hsa047400.62798481
133Cocaine addiction_Homo sapiens_hsa050300.62773535
134Arachidonic acid metabolism_Homo sapiens_hsa005900.62054591
135Retinol metabolism_Homo sapiens_hsa008300.52066497
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.50818358
137Fatty acid biosynthesis_Homo sapiens_hsa000610.49498647
138Selenocompound metabolism_Homo sapiens_hsa004500.49235505
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.49096420
140Ras signaling pathway_Homo sapiens_hsa040140.46122276
141Melanoma_Homo sapiens_hsa052180.45626615
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43708374
143Regulation of autophagy_Homo sapiens_hsa041400.41033538

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »