NCOR1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.83869924
2acrosome reaction (GO:0007340)9.32139675
3rRNA methylation (GO:0031167)8.47010647
4fusion of sperm to egg plasma membrane (GO:0007342)8.42955866
5rRNA modification (GO:0000154)7.90560074
6chromosome condensation (GO:0030261)7.03182879
7spermatid development (GO:0007286)6.99381102
8sperm-egg recognition (GO:0035036)6.79123878
9DNA packaging (GO:0006323)6.64156177
10binding of sperm to zona pellucida (GO:0007339)6.57147766
11multicellular organism reproduction (GO:0032504)6.54050824
12protein polyglutamylation (GO:0018095)6.42936276
13microtubule depolymerization (GO:0007019)6.38104204
14plasma membrane fusion (GO:0045026)6.37160847
15spermatid nucleus differentiation (GO:0007289)6.33507456
16axonemal dynein complex assembly (GO:0070286)6.01872873
17response to pheromone (GO:0019236)5.79383055
18sperm capacitation (GO:0048240)5.69023506
19single strand break repair (GO:0000012)5.63971268
20reproduction (GO:0000003)5.59344988
21cell-cell recognition (GO:0009988)5.58977496
22cellular ketone body metabolic process (GO:0046950)5.39108084
23single fertilization (GO:0007338)5.32038820
24microtubule polymerization or depolymerization (GO:0031109)5.09958552
25calcium ion-dependent exocytosis (GO:0017156)5.00363812
26regulation of cilium movement (GO:0003352)5.00026154
27spermatogenesis (GO:0007283)4.99652059
28male gamete generation (GO:0048232)4.97930679
29motile cilium assembly (GO:0044458)4.75342767
30ketone body metabolic process (GO:1902224)4.72015656
31cilium or flagellum-dependent cell motility (GO:0001539)4.71011409
32gamete generation (GO:0007276)4.58960143
33protein targeting to Golgi (GO:0000042)4.50616520
34microtubule severing (GO:0051013)4.49665689
35glycerol ether metabolic process (GO:0006662)4.45736137
36seminiferous tubule development (GO:0072520)4.40562437
37organic cation transport (GO:0015695)4.34035884
38establishment of protein localization to Golgi (GO:0072600)4.31945859
39retrograde transport, vesicle recycling within Golgi (GO:0000301)4.29701272
40epithelial cilium movement (GO:0003351)4.24120964
41ether metabolic process (GO:0018904)4.20156638
42centriole replication (GO:0007099)4.19057055
43fertilization (GO:0009566)4.17800534
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.17701982
45coenzyme catabolic process (GO:0009109)4.13346470
46male meiosis (GO:0007140)4.03873382
47microtubule nucleation (GO:0007020)3.92525839
48sexual reproduction (GO:0019953)3.87862722
49germ cell development (GO:0007281)3.85084277
50centriole assembly (GO:0098534)3.81063928
51phosphatidylethanolamine metabolic process (GO:0046337)3.77462404
52regulation of transcription involved in cell fate commitment (GO:0060850)3.66924744
53cilium movement (GO:0003341)3.65958128
54chaperone-mediated protein transport (GO:0072321)3.64591730
55multicellular organismal reproductive process (GO:0048609)3.59565497
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57145313
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57145313
58piRNA metabolic process (GO:0034587)3.56014564
59polyamine biosynthetic process (GO:0006596)3.50990686
60phenylpropanoid metabolic process (GO:0009698)3.46413498
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.45904447
62cell wall macromolecule metabolic process (GO:0044036)3.42698117
63DNA methylation involved in gamete generation (GO:0043046)3.42056981
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39103129
65negative regulation of inclusion body assembly (GO:0090084)3.38603560
66cell wall macromolecule catabolic process (GO:0016998)3.35475064
67histone exchange (GO:0043486)3.35422678
68positive regulation of Rab GTPase activity (GO:0032851)3.34743586
69regulation of Rab GTPase activity (GO:0032313)3.34743586
70positive regulation of endothelial cell differentiation (GO:0045603)3.30605710
71peroxisome fission (GO:0016559)3.30061041
72flavonoid metabolic process (GO:0009812)3.26628138
73protein localization to Golgi apparatus (GO:0034067)3.18980575
74regulation of centriole replication (GO:0046599)3.17633087
75aminoglycoside antibiotic metabolic process (GO:0030647)3.13281518
76RNA methylation (GO:0001510)3.08832273
77tRNA methylation (GO:0030488)2.99224397
78NAD biosynthetic process (GO:0009435)2.98615739
79regulation of phosphoprotein phosphatase activity (GO:0043666)2.97238105
80male meiosis I (GO:0007141)2.95868924
81chromatin silencing (GO:0006342)2.94368777
82regulation of microtubule-based movement (GO:0060632)2.93379665
83multicellular organismal movement (GO:0050879)2.92191010
84musculoskeletal movement (GO:0050881)2.92191010
85detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.89212592
86purine nucleotide salvage (GO:0032261)2.88491393
87RNA destabilization (GO:0050779)2.88229199
88ventricular system development (GO:0021591)2.75418174
89cellular zinc ion homeostasis (GO:0006882)2.74917658
90membrane protein intracellular domain proteolysis (GO:0031293)2.70458262
91nucleosome disassembly (GO:0006337)2.67114798
92protein-DNA complex disassembly (GO:0032986)2.67114798
93regulation of inclusion body assembly (GO:0090083)2.64832579
94cofactor catabolic process (GO:0051187)2.63338724
95nucleus organization (GO:0006997)2.57915443
96tryptophan catabolic process (GO:0006569)2.56472459
97indole-containing compound catabolic process (GO:0042436)2.56472459
98indolalkylamine catabolic process (GO:0046218)2.56472459
99cilium assembly (GO:0042384)2.55285518
100cilium organization (GO:0044782)2.53261463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.33347935
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.69051092
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.75894894
4ZNF274_21170338_ChIP-Seq_K562_Hela2.59898951
5FUS_26573619_Chip-Seq_HEK293_Human2.49765141
6CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34386147
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25918663
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23389858
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11946250
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.05144309
11CBP_20019798_ChIP-Seq_JUKART_Human1.98381028
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.98381028
13NANOG_20526341_ChIP-Seq_ESCs_Human1.95344893
14ERA_21632823_ChIP-Seq_H3396_Human1.90561691
15EZH2_22144423_ChIP-Seq_EOC_Human1.89286835
16RAC3_21632823_ChIP-Seq_H3396_Human1.88504621
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.87490758
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86633766
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.86346662
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82683754
21ER_23166858_ChIP-Seq_MCF-7_Human1.82133456
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.77315610
23VDR_22108803_ChIP-Seq_LS180_Human1.69087927
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.67651769
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66646273
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64999232
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64999232
28EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.64143754
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59618002
30OCT4_20526341_ChIP-Seq_ESCs_Human1.58469924
31BCL6_27268052_Chip-Seq_Bcells_Human1.58314507
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56375251
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.55163317
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54251171
35MYC_19829295_ChIP-Seq_ESCs_Human1.54061926
36ERG_20517297_ChIP-Seq_VCAP_Human1.53734678
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53583975
38E2F1_20622854_ChIP-Seq_HELA_Human1.53129820
39TAF2_19829295_ChIP-Seq_ESCs_Human1.49939919
40NCOR_22424771_ChIP-Seq_293T_Human1.48103109
41PHF8_20622854_ChIP-Seq_HELA_Human1.47653243
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.46984897
43CTCF_20526341_ChIP-Seq_ESCs_Human1.44645127
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.41631199
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.40187197
46RBPJ_21746931_ChIP-Seq_IB4_Human1.39597132
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.38517097
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38437085
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37163835
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.37163835
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36908792
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36516538
53P300_27268052_Chip-Seq_Bcells_Human1.36101879
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35837503
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33080966
56NANOG_19829295_ChIP-Seq_ESCs_Human1.31912401
57SOX2_19829295_ChIP-Seq_ESCs_Human1.31912401
58P68_20966046_ChIP-Seq_HELA_Human1.30756851
59BCOR_27268052_Chip-Seq_Bcells_Human1.27759036
60P300_19829295_ChIP-Seq_ESCs_Human1.27368999
61PHF8_20622853_ChIP-Seq_HELA_Human1.27262766
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26517108
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.25004300
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24808549
65HOXB7_26014856_ChIP-Seq_BT474_Human1.24287511
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.24023318
67STAT1_20625510_ChIP-Seq_HELA_Human1.21803416
68ETV1_20927104_ChIP-Seq_GIST48_Human1.20508649
69P53_21459846_ChIP-Seq_SAOS-2_Human1.20363933
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.19402899
71AR_25329375_ChIP-Seq_VCAP_Human1.18776503
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.17950257
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17890830
74RUNX2_22187159_ChIP-Seq_PCA_Human1.17509716
75CEBPB_22108803_ChIP-Seq_LS180_Human1.16312998
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15452311
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15363659
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.14659106
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13050705
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12693249
81E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12576539
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11362336
83SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10959853
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.10843199
85SPI1_20517297_ChIP-Seq_HL60_Human1.10172146
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09041393
87NFYB_21822215_ChIP-Seq_K562_Human1.08938542
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07736489
89CTCF_27219007_Chip-Seq_Bcells_Human1.06357191
90TBL1_22424771_ChIP-Seq_293T_Human1.05787557
91TP63_22573176_ChIP-Seq_HFKS_Human1.02338844
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02161042
93SMC4_20622854_ChIP-Seq_HELA_Human1.01673049
94GBX2_23144817_ChIP-Seq_PC3_Human1.00895658
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97758379
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96531084
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96455033
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94520605
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94342580
100SOX2_21211035_ChIP-Seq_LN229_Human0.94143556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.52885274
2MP0005670_abnormal_white_adipose4.35246359
3MP0003878_abnormal_ear_physiology3.97270107
4MP0005377_hearing/vestibular/ear_phenot3.97270107
5MP0003698_abnormal_male_reproductive3.57970184
6MP0001929_abnormal_gametogenesis3.20903505
7MP0003806_abnormal_nucleotide_metabolis2.78341157
8MP0005646_abnormal_pituitary_gland2.49393550
9MP0003718_maternal_effect2.26602404
10MP0002938_white_spotting2.24421295
11MP0005379_endocrine/exocrine_gland_phen2.21796024
12MP0001348_abnormal_lacrimal_gland2.20245785
13MP0002132_abnormal_respiratory_system2.03788729
14MP0000678_abnormal_parathyroid_gland1.99140635
15MP0002161_abnormal_fertility/fecundity1.97526867
16MP0008995_early_reproductive_senescence1.91503025
17MP0002638_abnormal_pupillary_reflex1.81501255
18MP0002210_abnormal_sex_determination1.76039713
19MP0001968_abnormal_touch/_nociception1.70569160
20MP0001485_abnormal_pinna_reflex1.67708701
21MP0009697_abnormal_copulation1.64910917
22MP0002160_abnormal_reproductive_system1.61503361
23MP0001764_abnormal_homeostasis1.53310204
24MP0001145_abnormal_male_reproductive1.51576726
25MP0000653_abnormal_sex_gland1.46179113
26MP0001905_abnormal_dopamine_level1.45682333
27MP0008877_abnormal_DNA_methylation1.42355234
28MP0005360_urolithiasis1.40375359
29MP0001486_abnormal_startle_reflex1.36629419
30MP0005332_abnormal_amino_acid1.32788517
31MP0008004_abnormal_stomach_pH1.31904252
32MP0009780_abnormal_chondrocyte_physiolo1.29048218
33MP0005551_abnormal_eye_electrophysiolog1.26964178
34MP0003879_abnormal_hair_cell1.24488179
35MP0005253_abnormal_eye_physiology1.24233069
36MP0002127_abnormal_cardiovascular_syste1.22718160
37MP0000516_abnormal_urinary_system1.19455911
38MP0005367_renal/urinary_system_phenotyp1.19455911
39MP0006036_abnormal_mitochondrial_physio1.19239025
40MP0001765_abnormal_ion_homeostasis1.14001694
41MP0002736_abnormal_nociception_after1.12048503
42MP0005636_abnormal_mineral_homeostasis1.11698373
43MP0005451_abnormal_body_composition1.10399280
44MP0001963_abnormal_hearing_physiology1.08927010
45MP0000013_abnormal_adipose_tissue1.08017020
46MP0002735_abnormal_chemical_nociception1.07596568
47MP0002138_abnormal_hepatobiliary_system1.05983888
48MP0003077_abnormal_cell_cycle1.01142844
49MP0002837_dystrophic_cardiac_calcinosis1.00461387
50MP0000026_abnormal_inner_ear0.99176015
51MP0000372_irregular_coat_pigmentation0.97987178
52MP0004085_abnormal_heartbeat0.97705518
53MP0004019_abnormal_vitamin_homeostasis0.95157750
54MP0002229_neurodegeneration0.93064251
55MP0002249_abnormal_larynx_morphology0.92768861
56MP0009046_muscle_twitch0.92524568
57MP0005395_other_phenotype0.91243358
58MP0005389_reproductive_system_phenotype0.90898468
59MP0000534_abnormal_ureter_morphology0.90229752
60MP0008875_abnormal_xenobiotic_pharmacok0.87955876
61MP0002234_abnormal_pharynx_morphology0.86140638
62MP0003011_delayed_dark_adaptation0.83467440
63MP0000230_abnormal_systemic_arterial0.82621728
64MP0002733_abnormal_thermal_nociception0.82308593
65MP0010368_abnormal_lymphatic_system0.82109946
66MP0009745_abnormal_behavioral_response0.81802545
67MP0005248_abnormal_Harderian_gland0.79934159
68MP0001944_abnormal_pancreas_morphology0.79490055
69MP0009115_abnormal_fat_cell0.78546226
70MP0008872_abnormal_physiological_respon0.78420364
71MP0008058_abnormal_DNA_repair0.77914453
72MP0001756_abnormal_urination0.75963606
73MP0000049_abnormal_middle_ear0.74583573
74MP0003137_abnormal_impulse_conducting0.73653100
75MP0001666_abnormal_nutrient_absorption0.72265925
76MP0000681_abnormal_thyroid_gland0.70403026
77MP0005423_abnormal_somatic_nervous0.70088777
78MP0003646_muscle_fatigue0.65672187
79MP0004510_myositis0.64445080
80MP0005645_abnormal_hypothalamus_physiol0.63069127
81MP0002693_abnormal_pancreas_physiology0.62828962
82MP0003936_abnormal_reproductive_system0.62462614
83MP0004885_abnormal_endolymph0.61263994
84MP0000631_abnormal_neuroendocrine_gland0.61260702
85MP0003693_abnormal_embryo_hatching0.60033547
86MP0005084_abnormal_gallbladder_morpholo0.59895800
87MP0002557_abnormal_social/conspecific_i0.59815601
88MP0002822_catalepsy0.59381914
89MP0003786_premature_aging0.59207348
90MP0001270_distended_abdomen0.58776978
91MP0001529_abnormal_vocalization0.57266915
92MP0002067_abnormal_sensory_capabilities0.56892902
93MP0006276_abnormal_autonomic_nervous0.56045387
94MP0004742_abnormal_vestibular_system0.54832079
95MP0002572_abnormal_emotion/affect_behav0.53584155
96MP0001661_extended_life_span0.53143268
97MP0009643_abnormal_urine_homeostasis0.52171263
98MP0001984_abnormal_olfaction0.51716120
99MP0005266_abnormal_metabolism0.50846811
100MP0001970_abnormal_pain_threshold0.50678435

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.78577319
2Absent/shortened dynein arms (HP:0200106)5.78577319
3Severe visual impairment (HP:0001141)5.30966391
4Generalized aminoaciduria (HP:0002909)5.20681176
5Abnormal respiratory epithelium morphology (HP:0012253)4.54707059
6Abnormal respiratory motile cilium morphology (HP:0005938)4.54707059
7Abnormal ciliary motility (HP:0012262)4.50052955
8Attenuation of retinal blood vessels (HP:0007843)4.28580279
9Abnormal respiratory motile cilium physiology (HP:0012261)4.19289367
10Tubulointerstitial nephritis (HP:0001970)4.12746585
11Chronic hepatic failure (HP:0100626)3.92075103
12Renal Fanconi syndrome (HP:0001994)3.92011377
13Asymmetric septal hypertrophy (HP:0001670)3.57266639
14Bony spicule pigmentary retinopathy (HP:0007737)3.35226148
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34677080
16Abnormality of macular pigmentation (HP:0008002)3.21505088
17Abnormal rod and cone electroretinograms (HP:0008323)3.18608045
18Resting tremor (HP:0002322)3.17756471
19Congenital sensorineural hearing impairment (HP:0008527)3.11842227
20Proximal tubulopathy (HP:0000114)3.11610784
21Infertility (HP:0000789)3.09960075
22Glycosuria (HP:0003076)3.06440647
23Abnormality of urine glucose concentration (HP:0011016)3.06440647
24Abnormality of alanine metabolism (HP:0010916)2.75900602
25Hyperalaninemia (HP:0003348)2.75900602
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75900602
27Abnormality of fatty-acid metabolism (HP:0004359)2.75756021
28Hyperkalemia (HP:0002153)2.66694906
29Constricted visual fields (HP:0001133)2.66143052
30Male infertility (HP:0003251)2.64626142
31Hyperphosphaturia (HP:0003109)2.56763472
32Nephronophthisis (HP:0000090)2.49013345
33Cone-rod dystrophy (HP:0000548)2.48613470
34Double outlet right ventricle (HP:0001719)2.47293314
35Congenital malformation of the right heart (HP:0011723)2.47293314
36Abnormality of renal resorption (HP:0011038)2.46612875
37Median cleft lip (HP:0000161)2.45889309
38Pancreatic fibrosis (HP:0100732)2.44275681
39Aplasia/hypoplasia of the uterus (HP:0008684)2.38833905
40Occipital encephalocele (HP:0002085)2.36925146
41Nasal polyposis (HP:0100582)2.33748600
42Pancreatic cysts (HP:0001737)2.30061189
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29951401
44Pendular nystagmus (HP:0012043)2.28117062
45Delayed CNS myelination (HP:0002188)2.27449559
46Hypoplasia of the thymus (HP:0000778)2.26196523
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24455777
48Rhinitis (HP:0012384)2.23435157
49Sensory axonal neuropathy (HP:0003390)2.14211310
50True hermaphroditism (HP:0010459)2.13673663
51Myokymia (HP:0002411)2.10239701
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08889096
53Abnormality of dental color (HP:0011073)2.07593181
54Progressive cerebellar ataxia (HP:0002073)2.06656493
55Polydipsia (HP:0001959)2.05761269
56Abnormal drinking behavior (HP:0030082)2.05761269
57Hyperuricemia (HP:0002149)2.05210534
58Increased purine levels (HP:0004368)2.05210534
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02996861
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02996861
61Abnormal urine output (HP:0012590)2.01517950
62Bell-shaped thorax (HP:0001591)1.98255473
63Hypoplasia of the uterus (HP:0000013)1.94988262
64Insulin-resistant diabetes mellitus (HP:0000831)1.94573497
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92643916
66Hypergonadotropic hypogonadism (HP:0000815)1.92595021
673-Methylglutaconic aciduria (HP:0003535)1.91881594
68Abnormal urine phosphate concentration (HP:0012599)1.90760578
69Abnormality of the renal medulla (HP:0100957)1.90107129
70Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89332064
71Abnormality of sulfur amino acid metabolism (HP:0004339)1.89298355
72Poor speech (HP:0002465)1.87953542
73Stage 5 chronic kidney disease (HP:0003774)1.87852682
74Sclerocornea (HP:0000647)1.86138486
75Osteomalacia (HP:0002749)1.86105553
76Hypoalphalipoproteinemia (HP:0003233)1.85600033
77Portal hypertension (HP:0001409)1.85166500
78Abnormal spermatogenesis (HP:0008669)1.83706955
79Male pseudohermaphroditism (HP:0000037)1.82730155
80Transposition of the great arteries (HP:0001669)1.79585933
81Abnormal connection of the cardiac segments (HP:0011545)1.79585933
82Abnormal ventriculo-arterial connection (HP:0011563)1.79585933
83Polyuria (HP:0000103)1.78977369
84Abnormality of renal excretion (HP:0011036)1.78052102
85Brushfield spots (HP:0001088)1.77989706
86Anencephaly (HP:0002323)1.77984087
87Mitochondrial inheritance (HP:0001427)1.77699731
88Amelogenesis imperfecta (HP:0000705)1.77288378
89Abnormality of potassium homeostasis (HP:0011042)1.76953565
90Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75386188
91Abnormality of purine metabolism (HP:0004352)1.74212571
92Unilateral renal agenesis (HP:0000122)1.74181207
93Abnormality of the hepatic vasculature (HP:0006707)1.71710506
94Facial shape deformation (HP:0011334)1.71700710
95Potter facies (HP:0002009)1.71700710
96Hepatic necrosis (HP:0002605)1.71683471
97Bronchiectasis (HP:0002110)1.69334665
98Hyponatremia (HP:0002902)1.68664938
99Abnormality of the nasal mucosa (HP:0000433)1.67374320
100Tetany (HP:0001281)1.66495757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K28.63617690
2PLK45.99244215
3TESK13.56164951
4INSRR2.87082363
5TLK12.31445119
6PINK12.24490792
7MST1R2.07115036
8ZAK2.05282252
9PLK21.99266665
10BRD41.85502411
11STK38L1.83008448
12DDR21.68403385
13ARAF1.64817373
14BRSK21.63647045
15STK381.59232557
16VRK21.54315168
17FRK1.51325379
18MARK31.50260124
19NME21.47904588
20PHKG21.40483170
21PHKG11.40483170
22VRK11.38316280
23MST41.34203946
24MAPK151.33883537
25PNCK1.22271457
26PIM21.18815458
27BCKDK1.07929564
28ADRBK21.05412462
29MYLK1.05006079
30CDK191.03127422
31CDK71.01219226
32CCNB10.99800779
33PIK3CG0.99640217
34CDK90.96816897
35BRSK10.96331402
36TAF10.91553819
37TAOK30.90132629
38PDPK10.89444798
39PDK10.89239124
40MAP2K70.89001696
41NME10.85988557
42PRKD30.81770879
43PRKG20.81260149
44BMPR1B0.80852337
45OXSR10.79550696
46AURKA0.76961465
47NEK20.76700588
48NEK60.73164083
49MAP3K40.68487618
50MAP3K30.67077377
51MAP3K110.66947422
52CDK80.65890144
53CSNK1G30.64803662
54RPS6KB20.63541421
55CDK30.61043809
56BRAF0.60750666
57SGK4940.59965084
58SGK2230.59965084
59CSNK1A1L0.57738158
60TIE10.57449621
61MAPKAPK30.56248760
62PTK2B0.54145684
63RPS6KA50.51489928
64STK160.50420483
65DYRK1B0.47182433
66CSNK1G20.46863610
67TRIM280.46833365
68RPS6KA10.42864609
69DYRK20.42571354
70CAMK10.37884671
71PLK10.37580907
72NUAK10.35431827
73PRKCI0.34841248
74CSNK1A10.34723842
75PRKG10.34162463
76CSNK1G10.33894646
77TNIK0.32124935
78NTRK30.31904536
79TESK20.31856418
80TXK0.31614316
81MAPKAPK50.30985409
82PRKCE0.29455232
83MUSK0.27337021
84TNK20.26364417
85PRKCQ0.26108751
86PRKAA20.25337980
87MAPK110.24972440
88OBSCN0.24801790
89LATS10.24151760
90GRK50.23678257
91PRKACB0.21806542
92GRK10.21269269
93CDC70.20895117
94CDK10.20562448
95RPS6KA40.20060676
96CAMK2G0.19663455
97PBK0.19636666
98CAMK1G0.17780509
99AKT20.17732201
100JAK30.17668314

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.72467295
2Oxidative phosphorylation_Homo sapiens_hsa001902.65529100
3Olfactory transduction_Homo sapiens_hsa047402.64594376
4Ribosome_Homo sapiens_hsa030102.55644791
5Fatty acid biosynthesis_Homo sapiens_hsa000612.40385843
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39057534
7Butanoate metabolism_Homo sapiens_hsa006502.32983851
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29984750
9Retinol metabolism_Homo sapiens_hsa008302.27322827
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12350685
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.09901977
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06755190
13Chemical carcinogenesis_Homo sapiens_hsa052042.04655319
14Proteasome_Homo sapiens_hsa030502.02094666
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97302747
16Parkinsons disease_Homo sapiens_hsa050121.96943372
17Huntingtons disease_Homo sapiens_hsa050161.82802718
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.82062468
19RNA transport_Homo sapiens_hsa030131.79805162
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.64887614
21One carbon pool by folate_Homo sapiens_hsa006701.64369523
22RNA polymerase_Homo sapiens_hsa030201.62709751
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61846528
24Selenocompound metabolism_Homo sapiens_hsa004501.57870905
25Alzheimers disease_Homo sapiens_hsa050101.51131156
26Sulfur metabolism_Homo sapiens_hsa009201.50251149
27Basal transcription factors_Homo sapiens_hsa030221.50081786
28Taste transduction_Homo sapiens_hsa047421.45878542
29Sulfur relay system_Homo sapiens_hsa041221.45287101
30Cardiac muscle contraction_Homo sapiens_hsa042601.39441695
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37007565
32Arginine biosynthesis_Homo sapiens_hsa002201.33876940
33Purine metabolism_Homo sapiens_hsa002301.30717319
34Peroxisome_Homo sapiens_hsa041461.26613420
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25691344
36Glutathione metabolism_Homo sapiens_hsa004801.23304045
37Homologous recombination_Homo sapiens_hsa034401.22083761
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20156923
39Pyrimidine metabolism_Homo sapiens_hsa002401.17860009
40Fanconi anemia pathway_Homo sapiens_hsa034601.14921791
41Phototransduction_Homo sapiens_hsa047441.09560023
42Nucleotide excision repair_Homo sapiens_hsa034201.09303242
43Folate biosynthesis_Homo sapiens_hsa007901.05000922
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04137257
45Protein export_Homo sapiens_hsa030601.03759743
46Starch and sucrose metabolism_Homo sapiens_hsa005001.03547968
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98950620
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.98856309
49Metabolic pathways_Homo sapiens_hsa011000.96257392
50Type I diabetes mellitus_Homo sapiens_hsa049400.95961640
51RNA degradation_Homo sapiens_hsa030180.94718997
52Mismatch repair_Homo sapiens_hsa034300.93199675
53Base excision repair_Homo sapiens_hsa034100.88241772
54DNA replication_Homo sapiens_hsa030300.85657993
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83696750
56Collecting duct acid secretion_Homo sapiens_hsa049660.77414002
57Renin-angiotensin system_Homo sapiens_hsa046140.75896400
58Phenylalanine metabolism_Homo sapiens_hsa003600.74845215
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73925183
60Spliceosome_Homo sapiens_hsa030400.72100024
61Propanoate metabolism_Homo sapiens_hsa006400.71516189
62Morphine addiction_Homo sapiens_hsa050320.70782891
63Oocyte meiosis_Homo sapiens_hsa041140.69928301
64Nicotine addiction_Homo sapiens_hsa050330.69903480
65mRNA surveillance pathway_Homo sapiens_hsa030150.69500722
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67147075
67Tyrosine metabolism_Homo sapiens_hsa003500.65651045
68Nitrogen metabolism_Homo sapiens_hsa009100.65475887
69Hedgehog signaling pathway_Homo sapiens_hsa043400.65071637
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64813313
71Fatty acid degradation_Homo sapiens_hsa000710.64520109
72Regulation of autophagy_Homo sapiens_hsa041400.61551441
73ABC transporters_Homo sapiens_hsa020100.59886388
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57729093
75Allograft rejection_Homo sapiens_hsa053300.55668523
76Arginine and proline metabolism_Homo sapiens_hsa003300.54899758
77Fatty acid metabolism_Homo sapiens_hsa012120.54753653
78Salivary secretion_Homo sapiens_hsa049700.53413399
79Circadian entrainment_Homo sapiens_hsa047130.52458705
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51833896
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51713932
82Synaptic vesicle cycle_Homo sapiens_hsa047210.50743079
83Linoleic acid metabolism_Homo sapiens_hsa005910.48734417
84Fat digestion and absorption_Homo sapiens_hsa049750.48610695
85GABAergic synapse_Homo sapiens_hsa047270.48372460
86Arachidonic acid metabolism_Homo sapiens_hsa005900.47530927
87Caffeine metabolism_Homo sapiens_hsa002320.44476687
88Glycerolipid metabolism_Homo sapiens_hsa005610.44154019
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.43969611
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43066975
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42811351
92Systemic lupus erythematosus_Homo sapiens_hsa053220.39179916
93Biosynthesis of amino acids_Homo sapiens_hsa012300.38866948
94Alcoholism_Homo sapiens_hsa050340.37722954
95N-Glycan biosynthesis_Homo sapiens_hsa005100.37331610
96Tryptophan metabolism_Homo sapiens_hsa003800.36688794
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36225228
98Graft-versus-host disease_Homo sapiens_hsa053320.34090668
99Galactose metabolism_Homo sapiens_hsa000520.33960406
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32991689

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