NCOR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoskeletal anchoring at plasma membrane (GO:0007016)3.94402705
2negative regulation of erythrocyte differentiation (GO:0045647)3.72734883
3endothelial cell chemotaxis (GO:0035767)3.63104082
4plasma membrane repair (GO:0001778)3.58757688
5mannose metabolic process (GO:0006013)3.46671173
6positive regulation of histone deacetylation (GO:0031065)3.35864939
7activation of Rac GTPase activity (GO:0032863)3.33759829
8regulation of glucose import in response to insulin stimulus (GO:2001273)3.29795879
9negative regulation of cell size (GO:0045792)3.29748691
10atrioventricular valve morphogenesis (GO:0003181)3.27300096
11cell-cell junction maintenance (GO:0045217)3.25897802
12apoptotic cell clearance (GO:0043277)3.24281067
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.23702007
14insulin-like growth factor receptor signaling pathway (GO:0048009)3.21513411
15protein heterotrimerization (GO:0070208)3.17585761
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14743819
17stress fiber assembly (GO:0043149)3.14184540
18positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.12855316
19regulation of NFAT protein import into nucleus (GO:0051532)3.08559940
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.06422812
21axon extension involved in axon guidance (GO:0048846)3.06422812
22vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.03988282
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03735296
24adherens junction assembly (GO:0034333)3.03307131
25planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99266968
26sodium ion export (GO:0071436)2.98629812
27positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.92746558
28cell-substrate junction assembly (GO:0007044)2.91469787
29establishment of nucleus localization (GO:0040023)2.91458007
30positive regulation of blood vessel endothelial cell migration (GO:0043536)2.91023142
31positive regulation of receptor recycling (GO:0001921)2.90192994
32negative regulation of fatty acid transport (GO:2000192)2.86689339
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.85629342
34barbed-end actin filament capping (GO:0051016)2.85473598
35peptidyl-lysine dimethylation (GO:0018027)2.83667117
36NLS-bearing protein import into nucleus (GO:0006607)2.82388837
37glucocorticoid receptor signaling pathway (GO:0042921)2.77747216
38response to laminar fluid shear stress (GO:0034616)2.76836472
39anatomical structure regression (GO:0060033)2.75773846
40gonadal mesoderm development (GO:0007506)2.74632351
41vascular endothelial growth factor signaling pathway (GO:0038084)2.73199720
42protein retention in ER lumen (GO:0006621)2.72467483
43establishment of apical/basal cell polarity (GO:0035089)2.72399857
44regulation of extracellular matrix disassembly (GO:0010715)2.71468782
45activation of MAPKKK activity (GO:0000185)2.71265854
46regulation of p38MAPK cascade (GO:1900744)2.70155602
47polarized epithelial cell differentiation (GO:0030859)2.68862761
48cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68219567
49cytoplasmic mRNA processing body assembly (GO:0033962)2.63754083
50cardiac myofibril assembly (GO:0055003)2.62996163
51cell-substrate adherens junction assembly (GO:0007045)2.62363932
52focal adhesion assembly (GO:0048041)2.62363932
53hippo signaling (GO:0035329)2.61694897
54cell volume homeostasis (GO:0006884)2.59384480
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58961280
56pre-miRNA processing (GO:0031054)2.58435054
57negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.58166675
58Golgi transport vesicle coating (GO:0048200)2.57692677
59COPI coating of Golgi vesicle (GO:0048205)2.57692677
60hemidesmosome assembly (GO:0031581)2.57202425
61desmosome organization (GO:0002934)2.57057410
62epithelial cell fate commitment (GO:0072148)2.56312787
63regulation of ARF GTPase activity (GO:0032312)2.56026360
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.55767672
65protein localization to endosome (GO:0036010)2.55679312
66endodermal cell differentiation (GO:0035987)2.54555962
67semaphorin-plexin signaling pathway (GO:0071526)2.53528330
68layer formation in cerebral cortex (GO:0021819)2.53505033
69intracellular estrogen receptor signaling pathway (GO:0030520)2.52792999
70stress granule assembly (GO:0034063)2.52276772
71neural tube development (GO:0021915)2.51592406
72cell communication by electrical coupling (GO:0010644)2.46267270
73coronary vasculature morphogenesis (GO:0060977)2.46132185
74positive regulation of glycogen biosynthetic process (GO:0045725)2.45782484
75negative regulation of myotube differentiation (GO:0010832)2.45421476
76protein targeting to plasma membrane (GO:0072661)2.43321136
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43041702
78embryonic eye morphogenesis (GO:0048048)2.42347472
79negative regulation of catenin import into nucleus (GO:0035414)2.42334603
80epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41789403
81positive regulation of Cdc42 GTPase activity (GO:0043089)2.41387729
82activation of JUN kinase activity (GO:0007257)2.40411504
83negative regulation of smooth muscle cell migration (GO:0014912)2.39207037
84heterochromatin organization (GO:0070828)2.39186383
85modulation by virus of host morphology or physiology (GO:0019048)2.39073320
86apoptotic process involved in morphogenesis (GO:0060561)2.38933267
87maternal placenta development (GO:0001893)2.38911694
88endocytic recycling (GO:0032456)2.38533486
89regulation of clathrin-mediated endocytosis (GO:2000369)2.37398723
90cortical actin cytoskeleton organization (GO:0030866)2.37227695
91actin filament bundle assembly (GO:0051017)2.37009676
92actin filament bundle organization (GO:0061572)2.37009676
93embryonic foregut morphogenesis (GO:0048617)2.36880570
94cell migration involved in heart development (GO:0060973)2.36609596
95myoblast fusion (GO:0007520)2.36016539
96negative regulation of potassium ion transmembrane transport (GO:1901380)2.35781138
97branching involved in mammary gland duct morphogenesis (GO:0060444)2.35778569
98peptidyl-tyrosine autophosphorylation (GO:0038083)2.34474955
99modulation by symbiont of host cellular process (GO:0044068)2.34443683
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.34275554
101glomerular basement membrane development (GO:0032836)2.33537035
102positive regulation of protein deacetylation (GO:0090312)2.33467147
103epithelial cell-cell adhesion (GO:0090136)2.33363108
104positive regulation of protein dephosphorylation (GO:0035307)2.33315459
105response to fluid shear stress (GO:0034405)2.32301851
106basement membrane organization (GO:0071711)2.31697937
107cell junction maintenance (GO:0034331)2.31441684
108regulation of endothelial cell chemotaxis (GO:2001026)2.31229622
109syncytium formation by plasma membrane fusion (GO:0000768)2.31218107
110regulation of histone H3-K27 methylation (GO:0061085)2.30919652
111locomotory exploration behavior (GO:0035641)2.30785109
112collagen fibril organization (GO:0030199)2.30590164
113apoptotic process involved in development (GO:1902742)2.29262358
114convergent extension (GO:0060026)2.29187478
115embryonic process involved in female pregnancy (GO:0060136)2.28866857
116establishment of monopolar cell polarity (GO:0061162)2.28752305
117establishment or maintenance of monopolar cell polarity (GO:0061339)2.28752305
118growth hormone secretion (GO:0030252)2.28299858
119eye morphogenesis (GO:0048592)2.27971053
120cardiac muscle cell proliferation (GO:0060038)2.27613598
121endothelial cell morphogenesis (GO:0001886)2.27231330
122cell migration involved in sprouting angiogenesis (GO:0002042)2.27100818
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26764370
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26730419
125* heart morphogenesis (GO:0003007)2.26684727
126synaptic vesicle maturation (GO:0016188)2.26665310
127branching involved in salivary gland morphogenesis (GO:0060445)2.26452876
128venous blood vessel morphogenesis (GO:0048845)2.26426377
129regulation of mammary gland epithelial cell proliferation (GO:0033599)2.25961773
130regulation of establishment of planar polarity (GO:0090175)2.25468918
131regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25122847
132bone trabecula formation (GO:0060346)2.25019125
133regulation of hippo signaling (GO:0035330)2.24888940
134establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.24830698
135synaptic vesicle docking involved in exocytosis (GO:0016081)2.24787481
136regulation of fatty acid beta-oxidation (GO:0031998)2.24340844
137regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23470639
138embryonic camera-type eye morphogenesis (GO:0048596)2.23162051
139skin morphogenesis (GO:0043589)2.22589610
140negative regulation of glial cell proliferation (GO:0060253)2.21586917
141regulation of early endosome to late endosome transport (GO:2000641)2.21200814
142response to muramyl dipeptide (GO:0032495)2.20180713
143regulation of ARF protein signal transduction (GO:0032012)2.20162951
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.19270980
145heparan sulfate proteoglycan metabolic process (GO:0030201)2.18736471
146corticosteroid receptor signaling pathway (GO:0031958)2.18721228
147glial cell proliferation (GO:0014009)2.18289003
148Rho protein signal transduction (GO:0007266)2.18167644
149camera-type eye morphogenesis (GO:0048593)2.18035098
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.17501025
151collecting duct development (GO:0072044)2.16284459
152syncytium formation (GO:0006949)2.15318724
153receptor catabolic process (GO:0032801)2.15286695
154positive regulation of osteoblast proliferation (GO:0033690)2.15002230
155renal filtration (GO:0097205)2.13781391
156blood vessel endothelial cell migration (GO:0043534)2.13373155
157negative regulation of nucleotide catabolic process (GO:0030812)2.13155916
158gastrulation with mouth forming second (GO:0001702)2.11821216
159regulation of tight junction assembly (GO:2000810)2.11669618
160adherens junction organization (GO:0034332)2.11629388
161negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.11567099
162signal complex assembly (GO:0007172)2.11324046
163cortical cytoskeleton organization (GO:0030865)2.10830433
164heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.10601758
165positive regulation of fibroblast migration (GO:0010763)2.10204490
166positive regulation of p38MAPK cascade (GO:1900745)2.10188093
167embryonic retina morphogenesis in camera-type eye (GO:0060059)2.09017972
168placenta blood vessel development (GO:0060674)2.07512703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19947583
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.00031682
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94773918
4* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.79147467
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69829299
6KDM2B_26808549_Chip-Seq_DND41_Human2.56340233
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.41504899
8* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.37856874
9* KDM2B_26808549_Chip-Seq_K562_Human2.28427433
10* MYC_22102868_ChIP-Seq_BL_Human2.27604112
11* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.27263417
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17852767
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.17575962
14* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11136136
15* LXR_22292898_ChIP-Seq_THP-1_Human2.10715772
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09216595
17* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06869351
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.06356106
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.03204452
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.02451959
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02285201
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00449569
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99253536
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95562942
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.95503367
26* DROSHA_22980978_ChIP-Seq_HELA_Human1.77174414
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75120930
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.74239448
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72992995
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72740003
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71672146
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.68669060
33* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67865306
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64397154
35* VDR_21846776_ChIP-Seq_THP-1_Human1.62751370
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.59626767
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49152495
38CLOCK_20551151_ChIP-Seq_293T_Human1.49087405
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49074296
40ZNF263_19887448_ChIP-Seq_K562_Human1.47065570
41* VDR_24763502_ChIP-Seq_THP-1_Human1.46959343
42CREB1_26743006_Chip-Seq_LNCaP_Human1.45161992
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41833230
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41408775
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40490318
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39686947
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37746698
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37082084
49* RARB_27405468_Chip-Seq_BRAIN_Mouse1.35089109
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34880340
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33196199
52* TBX20_22080862_ChIP-Seq_HEART_Mouse1.31714463
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.31714463
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.31342305
55* RUNX1_27514584_Chip-Seq_MCF-7_Human1.29813611
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28403118
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28403118
58* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27482963
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26294076
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.26138021
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25423601
62TP53_22127205_ChIP-Seq_IMR90_Human1.25349485
63* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25136312
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.24247028
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23542883
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23192124
67* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23130436
68* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18573376
69ATF3_27146783_Chip-Seq_COLON_Human1.16900785
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16745148
71* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16303658
72SPI1_23127762_ChIP-Seq_K562_Human1.15327589
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.15299352
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15179163
75* TP53_23651856_ChIP-Seq_MEFs_Mouse1.15047427
76* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13984467
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12837997
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.11622831
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10941178
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.10768025
81SMC4_20622854_ChIP-Seq_HELA_Human1.09447695
82* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07722122
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.07317690
84* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06711240
85* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06427883
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06409000
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05290214
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05148873
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04819773
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.04732440
91SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04676171
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04675685
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03556608
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03483001
95* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03440484
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03156015
97* NCOR1_26117541_ChIP-Seq_K562_Human1.01935896
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.01567858
99* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00976710
100P68_20966046_ChIP-Seq_HELA_Human1.00802195
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00241142
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.00112473
103UTX_26944678_Chip-Seq_JUKART_Human1.00099553
104BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99209566
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98912213
106* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98677387
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98614037
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98503116
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.98258286
110CTCF_27219007_Chip-Seq_Bcells_Human0.97672386
111JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97422860
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.96049396
113MAF_26560356_Chip-Seq_TH1_Human0.95448766
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95415908
115FOXA2_19822575_ChIP-Seq_HepG2_Human0.95308567
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.95162477
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94756344
118TP63_22573176_ChIP-Seq_HFKS_Human0.94172273
119* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93783926
120* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93681432
121* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93393453
122MAF_26560356_Chip-Seq_TH2_Human0.93026905
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92455225
124AHR_22903824_ChIP-Seq_MCF-7_Human0.92205209
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91457259
126RING1B_27294783_Chip-Seq_ESCs_Mouse0.90955276
127GATA1_19941826_ChIP-Seq_K562_Human0.90768123
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90527914
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89577188
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89512284
131SCL_19346495_ChIP-Seq_HPC-7_Human0.87716423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.26178230
2MP0008438_abnormal_cutaneous_collagen3.25503421
3MP0005623_abnormal_meninges_morphology3.03206895
4MP0000751_myopathy2.63835306
5MP0005409_darkened_coat_color2.45604975
6MP0003283_abnormal_digestive_organ2.42363067
7MP0008961_abnormal_basal_metabolism2.40671702
8MP0005058_abnormal_lysosome_morphology2.32089416
9MP0004858_abnormal_nervous_system2.26758788
10MP0009278_abnormal_bone_marrow2.22974562
11MP0003045_fibrosis2.14646809
12MP0000733_abnormal_muscle_development2.14080318
13MP0003566_abnormal_cell_adhesion2.11121209
14* MP0005076_abnormal_cell_differentiation2.08007756
15MP0003300_gastrointestinal_ulcer2.07391015
16MP0003279_aneurysm2.07313644
17MP0003453_abnormal_keratinocyte_physiol2.00011892
18MP0005275_abnormal_skin_tensile1.99296085
19MP0010352_gastrointestinal_tract_polyps1.98527892
20MP0004859_abnormal_synaptic_plasticity1.98324167
21MP0005451_abnormal_body_composition1.93734557
22MP0000569_abnormal_digit_pigmentation1.91234713
23MP0004233_abnormal_muscle_weight1.89548526
24MP0004084_abnormal_cardiac_muscle1.84823031
25MP0001849_ear_inflammation1.81494660
26MP0004272_abnormal_basement_membrane1.80791764
27MP0003091_abnormal_cell_migration1.77464885
28MP0004087_abnormal_muscle_fiber1.63066909
29MP0001958_emphysema1.61978426
30MP0010030_abnormal_orbit_morphology1.60656676
31MP0003115_abnormal_respiratory_system1.59496520
32MP0000678_abnormal_parathyroid_gland1.54574882
33MP0002234_abnormal_pharynx_morphology1.49675696
34MP0005503_abnormal_tendon_morphology1.49556518
35MP0004510_myositis1.46255734
36MP0000534_abnormal_ureter_morphology1.44788245
37MP0010630_abnormal_cardiac_muscle1.44747488
38MP0008260_abnormal_autophagy1.44592952
39MP0000428_abnormal_craniofacial_morphol1.43520293
40MP0000750_abnormal_muscle_regeneration1.40400664
41MP0002653_abnormal_ependyma_morphology1.40187129
42MP0009780_abnormal_chondrocyte_physiolo1.39745073
43MP0004947_skin_inflammation1.36937159
44MP0002796_impaired_skin_barrier1.36197840
45MP0009840_abnormal_foam_cell1.35613147
46MP0002877_abnormal_melanocyte_morpholog1.35143530
47MP0000003_abnormal_adipose_tissue1.35134227
48MP0002998_abnormal_bone_remodeling1.32031437
49MP0002108_abnormal_muscle_morphology1.30562388
50MP0004185_abnormal_adipocyte_glucose1.29421892
51MP0002269_muscular_atrophy1.26938978
52MP0000759_abnormal_skeletal_muscle1.26859701
53MP0002089_abnormal_postnatal_growth/wei1.26381513
54MP0004145_abnormal_muscle_electrophysio1.23501422
55MP0001299_abnormal_eye_distance/1.23430791
56MP0005023_abnormal_wound_healing1.22237486
57MP0005257_abnormal_intraocular_pressure1.18862192
58MP0001348_abnormal_lacrimal_gland1.16560588
59MP0002896_abnormal_bone_mineralization1.16114811
60MP0003385_abnormal_body_wall1.15015662
61MP0004197_abnormal_fetal_growth/weight/1.14184388
62MP0003942_abnormal_urinary_system1.13101582
63MP0002909_abnormal_adrenal_gland1.12209729
64MP0003303_peritoneal_inflammation1.12195019
65MP0000537_abnormal_urethra_morphology1.11145046
66MP0000749_muscle_degeneration1.10680016
67MP0005508_abnormal_skeleton_morphology1.09385576
68* MP0002925_abnormal_cardiovascular_devel1.09165499
69MP0010234_abnormal_vibrissa_follicle1.08596329
70MP0000747_muscle_weakness1.07628401
71MP0002168_other_aberrant_phenotype1.07150977
72MP0003122_maternal_imprinting1.06546188
73MP0003436_decreased_susceptibility_to1.06434304
74MP0009384_cardiac_valve_regurgitation1.04699398
75MP0003329_amyloid_beta_deposits1.03168628
76MP0009053_abnormal_anal_canal1.00567682
77MP0000767_abnormal_smooth_muscle0.99441811
78MP0000858_altered_metastatic_potential0.99057208
79MP0006138_congestive_heart_failure0.98984405
80MP0002106_abnormal_muscle_physiology0.98963369
81MP0000467_abnormal_esophagus_morphology0.97867069
82MP0002249_abnormal_larynx_morphology0.97380363
83MP0005330_cardiomyopathy0.97169008
84* MP0000266_abnormal_heart_morphology0.96490425
85MP0003634_abnormal_glial_cell0.96128972
86* MP0003935_abnormal_craniofacial_develop0.95667350
87MP0004036_abnormal_muscle_relaxation0.95413858
88MP0005369_muscle_phenotype0.93746429
89MP0005501_abnormal_skin_physiology0.92775976
90MP0005595_abnormal_vascular_smooth0.92406814
91MP0002837_dystrophic_cardiac_calcinosis0.92052906
92MP0002060_abnormal_skin_morphology0.91924288
93MP0005248_abnormal_Harderian_gland0.91206219
94MP0004808_abnormal_hematopoietic_stem0.90867580
95MP0002932_abnormal_joint_morphology0.90257234
96* MP0005621_abnormal_cell_physiology0.89163714
97MP0000566_synostosis0.88600873
98MP0002084_abnormal_developmental_patter0.88181141
99MP0004130_abnormal_muscle_cell0.87388135
100MP0001915_intracranial_hemorrhage0.85629464
101MP0002116_abnormal_craniofacial_bone0.85096090
102MP0002128_abnormal_blood_circulation0.85004156
103MP0010368_abnormal_lymphatic_system0.84794097
104MP0005390_skeleton_phenotype0.84712244
105* MP0005375_adipose_tissue_phenotype0.84523554
106MP0002697_abnormal_eye_size0.83450910
107MP0003075_altered_response_to0.83336758
108MP0003172_abnormal_lysosome_physiology0.82108932
109MP0006054_spinal_hemorrhage0.81786431
110MP0004381_abnormal_hair_follicle0.81687288
111MP0002933_joint_inflammation0.78908532
112MP0003191_abnormal_cellular_cholesterol0.78078701
113MP0000013_abnormal_adipose_tissue0.78049663
114* MP0005666_abnormal_adipose_tissue0.76939168
115MP0003119_abnormal_digestive_system0.76450583
116MP0003828_pulmonary_edema0.76073293
117MP0001784_abnormal_fluid_regulation0.75794324
118MP0004264_abnormal_extraembryonic_tissu0.75556546
119MP0003879_abnormal_hair_cell0.75022992
120MP0002254_reproductive_system_inflammat0.74897794
121MP0009703_decreased_birth_body0.73952972
122MP0002092_abnormal_eye_morphology0.73780426
123MP0001614_abnormal_blood_vessel0.73766349
124MP0009931_abnormal_skin_appearance0.73071873
125MP0002085_abnormal_embryonic_tissue0.72768755
126MP0003984_embryonic_growth_retardation0.72378704
127MP0002088_abnormal_embryonic_growth/wei0.71563794
128MP0000432_abnormal_head_morphology0.71276430
129MP0009672_abnormal_birth_weight0.71225186
130MP0000579_abnormal_nail_morphology0.70445643
131MP0008770_decreased_survivor_rate0.70355529
132MP0000462_abnormal_digestive_system0.67525678
133MP0000762_abnormal_tongue_morphology0.67520678
134MP0002113_abnormal_skeleton_development0.67487984
135MP0003690_abnormal_glial_cell0.66550557
136MP0001216_abnormal_epidermal_layer0.65716195
137MP0005397_hematopoietic_system_phenotyp0.65226552

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.28895144
2Cerebral aneurysm (HP:0004944)4.15768973
3Protrusio acetabuli (HP:0003179)4.07203400
4Shallow orbits (HP:0000586)4.04749639
5Broad face (HP:0000283)3.78773534
6Hyperacusis (HP:0010780)3.50594225
7Ankle contracture (HP:0006466)3.36119020
8Premature rupture of membranes (HP:0001788)3.25681854
9Broad metatarsal (HP:0001783)3.10615600
10Bladder diverticulum (HP:0000015)3.06791524
11Increased connective tissue (HP:0009025)2.97094466
12Distal upper limb amyotrophy (HP:0007149)2.96639898
13Upper limb amyotrophy (HP:0009129)2.96639898
14Atrophic scars (HP:0001075)2.78848210
15Mitral valve prolapse (HP:0001634)2.77194641
16Short 4th metacarpal (HP:0010044)2.76835539
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76835539
18Macroorchidism (HP:0000053)2.66149011
19Type 1 muscle fiber predominance (HP:0003803)2.64900462
20Hand muscle atrophy (HP:0009130)2.61539417
21Renal duplication (HP:0000075)2.59972635
22Bowel diverticulosis (HP:0005222)2.57742258
23Cervical subluxation (HP:0003308)2.56954534
24Aortic aneurysm (HP:0004942)2.51784111
25Genu recurvatum (HP:0002816)2.50893986
26Renovascular hypertension (HP:0100817)2.50578375
27Aneurysm (HP:0002617)2.48825539
28Mildly elevated creatine phosphokinase (HP:0008180)2.48523248
29Neoplasm of the heart (HP:0100544)2.48070912
30Dilatation of the ascending aorta (HP:0005111)2.47136774
31Increased variability in muscle fiber diameter (HP:0003557)2.44135421
32Elfin facies (HP:0004428)2.43944444
33Abnormality of the lower motor neuron (HP:0002366)2.42534514
34Aortic dissection (HP:0002647)2.42497752
35Difficulty running (HP:0009046)2.41963263
36Fragile skin (HP:0001030)2.36677183
37Insomnia (HP:0100785)2.36224305
38Distal lower limb muscle weakness (HP:0009053)2.33024460
39Abnormality of the 4th metacarpal (HP:0010012)2.31877179
40Enlarged penis (HP:0000040)2.30221177
41Difficulty climbing stairs (HP:0003551)2.18439442
42Lymphangioma (HP:0100764)2.17507778
43Long palpebral fissure (HP:0000637)2.16878801
44Urethral obstruction (HP:0000796)2.15771870
45Hyporeflexia of lower limbs (HP:0002600)2.15206352
46Flat cornea (HP:0007720)2.14630110
47Abnormality of skeletal muscle fiber size (HP:0012084)2.11883809
48Pointed chin (HP:0000307)2.11418460
49Overriding aorta (HP:0002623)2.10185854
50Turricephaly (HP:0000262)2.09353083
51Stridor (HP:0010307)2.08293608
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.07489154
53Deviation of the hallux (HP:0010051)2.07393864
54Flat acetabular roof (HP:0003180)2.07373547
55Vertebral compression fractures (HP:0002953)2.06984542
56Wormian bones (HP:0002645)2.05794390
57Peritonitis (HP:0002586)2.04614564
58Nuclear cataract (HP:0100018)2.02993932
59Striae distensae (HP:0001065)2.02941138
60Hallux valgus (HP:0001822)2.01994847
61Advanced eruption of teeth (HP:0006288)2.01579868
62Milia (HP:0001056)2.00938696
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.00057367
64Biconcave vertebral bodies (HP:0004586)1.98873343
65Disproportionate tall stature (HP:0001519)1.97915089
66J-shaped sella turcica (HP:0002680)1.97425739
67Narrow palate (HP:0000189)1.97364127
68Spinal rigidity (HP:0003306)1.92355268
69Spondylolisthesis (HP:0003302)1.89422493
70Trigonocephaly (HP:0000243)1.87718630
71Achilles tendon contracture (HP:0001771)1.86350928
72Blue sclerae (HP:0000592)1.86317234
73Ankyloglossia (HP:0010296)1.86280521
74Scapular winging (HP:0003691)1.85932243
75Premature skin wrinkling (HP:0100678)1.85464779
76Natal tooth (HP:0000695)1.85442273
77Hypoventilation (HP:0002791)1.85316691
78Slender build (HP:0001533)1.83976046
79Axonal loss (HP:0003447)1.83201452
80Cerebral inclusion bodies (HP:0100314)1.82863967
81Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82634987
82Broad thumb (HP:0011304)1.80676097
83Hemorrhage of the eye (HP:0011885)1.79332743
84Dislocated radial head (HP:0003083)1.78770950
85Long eyelashes (HP:0000527)1.78607800
86Neurofibrillary tangles (HP:0002185)1.78430351
87Thin ribs (HP:0000883)1.78421917
88Arnold-Chiari malformation (HP:0002308)1.78114028
89Abnormality of the thoracic spine (HP:0100711)1.77745019
90Lower limb amyotrophy (HP:0007210)1.76600153
91Distal lower limb amyotrophy (HP:0008944)1.75214790
92Persistence of primary teeth (HP:0006335)1.74825379
93Bronchomalacia (HP:0002780)1.74815995
94Thin bony cortex (HP:0002753)1.74414807
95Hypoplastic ischia (HP:0003175)1.74314046
96Wrist flexion contracture (HP:0001239)1.73755950
97Short nail (HP:0001799)1.73479823
98Asymmetry of the thorax (HP:0001555)1.73405828
99Osteolytic defects of the hand bones (HP:0009699)1.73307324
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.73307324
101Joint laxity (HP:0001388)1.73068138
102Abnormality of the fingertips (HP:0001211)1.72823992
103Rectal prolapse (HP:0002035)1.72483834
104Patellar dislocation (HP:0002999)1.71448507
105Ulnar bowing (HP:0003031)1.71371640
106Hypercortisolism (HP:0001578)1.70717451
107Dysmetric saccades (HP:0000641)1.70108963
108Precocious puberty (HP:0000826)1.70079557
109Aortic regurgitation (HP:0001659)1.70032303
110Hyperextensible skin (HP:0000974)1.69476526
111Abnormality of the astrocytes (HP:0100707)1.68118795
112Astrocytoma (HP:0009592)1.68118795
113Abnormality of the radial head (HP:0003995)1.67760583
114Vertebral arch anomaly (HP:0008438)1.66791386
115Easy fatigability (HP:0003388)1.66769990
116Arterial tortuosity (HP:0005116)1.65908323
117Abnormality of oral frenula (HP:0000190)1.65880909
118Increased nuchal translucency (HP:0010880)1.65124237
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64564069
120Interstitial pulmonary disease (HP:0006530)1.64415061
121Abnormality of the Achilles tendon (HP:0005109)1.62737883
122Genetic anticipation (HP:0003743)1.61979715
123Buphthalmos (HP:0000557)1.61720257
124Sudden death (HP:0001699)1.60526470
125Long toe (HP:0010511)1.60405298
126Selective tooth agenesis (HP:0001592)1.59814336
127Increased density of long bones (HP:0006392)1.59400439
128Right ventricular cardiomyopathy (HP:0011663)1.59225391
129Annular pancreas (HP:0001734)1.59211331
130Vascular tortuosity (HP:0004948)1.58998506
131Neonatal short-limb short stature (HP:0008921)1.58734170
132Emphysema (HP:0002097)1.58051781
133Dysostosis multiplex (HP:0000943)1.57595858
134Muscle fiber splitting (HP:0003555)1.56809446
135Obsessive-compulsive behavior (HP:0000722)1.56674009
136Generalized amyotrophy (HP:0003700)1.55743904
137Fibroma (HP:0010614)1.55517783
138Mitral regurgitation (HP:0001653)1.55210864
139Venous abnormality (HP:0002624)1.54936309
140Round ear (HP:0100830)1.54053889
141Overgrowth (HP:0001548)1.52584881
142Bundle branch block (HP:0011710)1.51503756
143Follicular hyperkeratosis (HP:0007502)1.51449768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.41227031
2CDK123.70371086
3PKN22.98976630
4PRPF4B2.83828162
5MAP3K102.72992865
6RIPK12.70292003
7SMG12.69919483
8EEF2K2.60448722
9TTN2.53439026
10IRAK32.53435317
11ICK2.49697320
12SIK12.47349053
13ERN12.44602125
14EPHA22.29280380
15PDGFRA2.26346890
16MST1R1.96091578
17PRKD31.94807791
18CAMK1G1.91553709
19TYRO31.82099747
20PTK61.79417979
21DMPK1.75668005
22CAMK1D1.68858588
23DDR21.68101517
24BMX1.62041030
25MTOR1.56244929
26SIK21.51421354
27NTRK11.49914501
28LATS11.42191552
29EPHB11.40272490
30TAOK11.37777722
31PTK21.37541660
32BRD41.33352396
33PAK61.32732160
34LATS21.31796340
35ALK1.24697101
36MAP3K71.21293069
37EPHB21.17590113
38PAK21.14456762
39MAP3K131.12918210
40CDC42BPA1.11197208
41PAK41.09120224
42MAP3K91.05414364
43PDGFRB1.01708633
44PRKCH1.01398411
45RET0.99144726
46TESK10.94906361
47MET0.94554428
48KSR20.92938501
49MARK20.92925199
50TNK20.91567638
51STK380.88217364
52IRAK20.88130136
53NTRK20.87666318
54CAMKK10.87602622
55TAOK20.85388358
56KSR10.84187244
57MAP2K30.83719387
58LMTK20.83419479
59FGFR10.83250492
60PRKD20.81502615
61MAP3K30.81192879
62RPS6KC10.80002237
63RPS6KL10.80002237
64NME20.79432717
65DAPK20.77252593
66WNK10.76834802
67TGFBR20.76536019
68LRRK20.76379165
69FER0.76273904
70ERBB20.75795650
71PAK30.73915485
72FGFR40.72979053
73PDPK10.72315718
74MAP3K60.70778596
75CAMK40.67669665
76NTRK30.67663004
77MAPK70.66870974
78MAP3K110.66542047
79DYRK1B0.66076676
80PRKD10.64591939
81CDK60.63455244
82PTK2B0.62836096
83MAP3K20.61281477
84FGFR30.60417967
85RPS6KA60.58546958
86MAPK120.58342234
87SGK30.57396262
88MAPK110.56842225
89SCYL20.56820564
90ARAF0.56178308
91HIPK20.56098153
92STK110.54445588
93SIK30.53544931
94PHKG20.53249981
95PHKG10.53249981
96RIPK40.52867682
97ROCK10.52664662
98MAP4K10.51444805
99TBK10.51278275
100NEK10.50806972
101MAP3K10.49841260
102MOS0.49672263
103ZAP700.47202488
104TRPM70.47189157
105PRKG20.46873732
106RPS6KA20.46816432
107FGFR20.45493236
108JAK10.45373063
109MAP2K20.44078637
110UHMK10.42335705
111MAP3K140.41787270
112MAPK80.41749266
113SRC0.41523297
114IRAK40.41424005
115CDK90.39709463
116ROCK20.38940496
117HCK0.38388046
118ILK0.37722909
119MINK10.36879776
120RPS6KA10.36638096
121CDK40.34993937
122MAPKAPK20.34170161
123MAP3K80.34006660
124* MAPK10.33893211
125STK100.33146572
126PDK10.32605669
127MAPK100.32507775
128RPS6KA30.32186610
129CAMK10.31928091
130MAP3K40.31868289
131BLK0.30323682
132MATK0.30251078
133STK30.29965324
134CSF1R0.29599404
135MELK0.29479887
136MAPK40.29448780
137FYN0.28604134
138CDK50.28498173
139EPHA30.28276124

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005111.96883677
2Focal adhesion_Homo sapiens_hsa045101.69276226
3Chronic myeloid leukemia_Homo sapiens_hsa052201.66727162
4Dilated cardiomyopathy_Homo sapiens_hsa054141.64543322
5ECM-receptor interaction_Homo sapiens_hsa045121.61399087
6Lysine degradation_Homo sapiens_hsa003101.58134836
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53196300
8Proteoglycans in cancer_Homo sapiens_hsa052051.52550417
9mTOR signaling pathway_Homo sapiens_hsa041501.49404494
10Adherens junction_Homo sapiens_hsa045201.49167253
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48308963
12Glioma_Homo sapiens_hsa052141.47085666
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45560452
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45051152
15Dorso-ventral axis formation_Homo sapiens_hsa043201.42010135
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40751681
17Type II diabetes mellitus_Homo sapiens_hsa049301.39260237
18Basal cell carcinoma_Homo sapiens_hsa052171.36699292
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35805759
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31402318
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.31364378
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31076875
23Prion diseases_Homo sapiens_hsa050201.30370284
24* Notch signaling pathway_Homo sapiens_hsa043301.29837641
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.28732115
26Amoebiasis_Homo sapiens_hsa051461.28077614
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27533477
28Estrogen signaling pathway_Homo sapiens_hsa049151.27031909
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23229574
30Endometrial cancer_Homo sapiens_hsa052131.23226983
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17975528
32Bladder cancer_Homo sapiens_hsa052191.17344623
33Non-small cell lung cancer_Homo sapiens_hsa052231.16456835
34MicroRNAs in cancer_Homo sapiens_hsa052061.15927282
35Hedgehog signaling pathway_Homo sapiens_hsa043401.15775727
36Hippo signaling pathway_Homo sapiens_hsa043901.15498886
37VEGF signaling pathway_Homo sapiens_hsa043701.14589120
38Small cell lung cancer_Homo sapiens_hsa052221.14152175
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.13470269
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11737488
41Insulin resistance_Homo sapiens_hsa049311.10007843
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07277843
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06806190
44GnRH signaling pathway_Homo sapiens_hsa049121.06590086
45Renal cell carcinoma_Homo sapiens_hsa052111.05334815
46Axon guidance_Homo sapiens_hsa043601.05289580
47Pancreatic cancer_Homo sapiens_hsa052121.05153821
48Viral myocarditis_Homo sapiens_hsa054161.04948352
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03677810
50Colorectal cancer_Homo sapiens_hsa052101.02842295
51ErbB signaling pathway_Homo sapiens_hsa040121.01378169
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00328988
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00263175
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.00152659
55Oxytocin signaling pathway_Homo sapiens_hsa049211.00072420
56Gastric acid secretion_Homo sapiens_hsa049710.99960886
57Acute myeloid leukemia_Homo sapiens_hsa052210.99252611
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97337024
59Protein digestion and absorption_Homo sapiens_hsa049740.97173892
60Insulin signaling pathway_Homo sapiens_hsa049100.96431052
61Melanogenesis_Homo sapiens_hsa049160.94688250
62Insulin secretion_Homo sapiens_hsa049110.94005149
63Nitrogen metabolism_Homo sapiens_hsa009100.93581088
64TNF signaling pathway_Homo sapiens_hsa046680.93171187
65Circadian entrainment_Homo sapiens_hsa047130.93119996
66Rap1 signaling pathway_Homo sapiens_hsa040150.92761427
67Gap junction_Homo sapiens_hsa045400.89828620
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89387462
69Long-term potentiation_Homo sapiens_hsa047200.88246791
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88233657
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87648126
72Platelet activation_Homo sapiens_hsa046110.86779102
73cAMP signaling pathway_Homo sapiens_hsa040240.85212680
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85178810
75Wnt signaling pathway_Homo sapiens_hsa043100.84923163
76Salivary secretion_Homo sapiens_hsa049700.82824248
77Hepatitis B_Homo sapiens_hsa051610.82199028
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82123363
79AMPK signaling pathway_Homo sapiens_hsa041520.81140306
80Prolactin signaling pathway_Homo sapiens_hsa049170.81006836
81Hepatitis C_Homo sapiens_hsa051600.80735847
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.79976641
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.79684446
84Tight junction_Homo sapiens_hsa045300.79473597
85MAPK signaling pathway_Homo sapiens_hsa040100.79259058
86Renin secretion_Homo sapiens_hsa049240.79046909
87Inositol phosphate metabolism_Homo sapiens_hsa005620.78845365
88Cholinergic synapse_Homo sapiens_hsa047250.78790386
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78734961
90Pathways in cancer_Homo sapiens_hsa052000.78481870
91Fructose and mannose metabolism_Homo sapiens_hsa000510.77763323
92Toxoplasmosis_Homo sapiens_hsa051450.77117360
93Lysosome_Homo sapiens_hsa041420.75718685
94Endocytosis_Homo sapiens_hsa041440.75352423
95Glucagon signaling pathway_Homo sapiens_hsa049220.75172757
96Pentose phosphate pathway_Homo sapiens_hsa000300.74468460
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74208470
98B cell receptor signaling pathway_Homo sapiens_hsa046620.73797649
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72054906
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70609026
101Prostate cancer_Homo sapiens_hsa052150.70308574
102Choline metabolism in cancer_Homo sapiens_hsa052310.70065775
103HTLV-I infection_Homo sapiens_hsa051660.69635367
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.69545412
105Cocaine addiction_Homo sapiens_hsa050300.68431930
106HIF-1 signaling pathway_Homo sapiens_hsa040660.67100550
107TGF-beta signaling pathway_Homo sapiens_hsa043500.67015763
108Osteoclast differentiation_Homo sapiens_hsa043800.66913397
109Influenza A_Homo sapiens_hsa051640.66434377
110Salmonella infection_Homo sapiens_hsa051320.65824109
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65077248
112Dopaminergic synapse_Homo sapiens_hsa047280.64730283
113Apoptosis_Homo sapiens_hsa042100.64586799
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63735139
115Thyroid cancer_Homo sapiens_hsa052160.63116414
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.62342536
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.61580830
118Galactose metabolism_Homo sapiens_hsa000520.60147818
119Olfactory transduction_Homo sapiens_hsa047400.59960620
120Leishmaniasis_Homo sapiens_hsa051400.59592823
121Glutamatergic synapse_Homo sapiens_hsa047240.59320392
122Malaria_Homo sapiens_hsa051440.57750195

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